Chapter 6: Structural Variation and Medical Genomics
Events
Loading … Spinner

CiteULike | Further Information

Mendeley | Further Information

{"title"=>"Chapter 6: Structural Variation and Medical Genomics", "type"=>"journal", "authors"=>[{"first_name"=>"Benjamin J.", "last_name"=>"Raphael", "scopus_author_id"=>"8848793700"}], "year"=>2012, "source"=>"PLoS Computational Biology", "identifiers"=>{"sgr"=>"84872040514", "doi"=>"10.1371/journal.pcbi.1002821", "pui"=>"368067276", "pmid"=>"23300412", "scopus"=>"2-s2.0-84872040514", "issn"=>"1553734X", "isbn"=>"1553-7358 (Electronic)\\r1553-734X (Linking)", "arxiv"=>"NIHMS150003"}, "id"=>"fa998251-accd-3560-b79a-adf14a780b76", "abstract"=>"Differences between individual human genomes, or between human and cancer genomes, range in scale from single nucleotide variants (SNVs) through intermediate and large-scale duplications, deletions, and rearrangements of genomic segments. The latter class, called structural variants (SVs), have received considerable attention in the past several years as they are a previously under appreciated source of variation in human genomes. Much of this recent attention is the result of the availability of higher-resolution technologies for measuring these variants, including both microarray-based techniques, and more recently, high-throughput DNA sequencing. We describe the genomic technologies and computational techniques currently used to measure SVs, focusing on applications in human and cancer genomics.", "link"=>"http://www.mendeley.com/research/chapter-6-structural-variation-medical-genomics", "reader_count"=>172, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Professor > Associate Professor"=>15, "Researcher"=>45, "Student > Doctoral Student"=>6, "Student > Ph. D. Student"=>51, "Student > Postgraduate"=>5, "Other"=>11, "Student > Master"=>15, "Student > Bachelor"=>11, "Lecturer"=>1, "Lecturer > Senior Lecturer"=>1, "Professor"=>10}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Professor > Associate Professor"=>15, "Researcher"=>45, "Student > Doctoral Student"=>6, "Student > Ph. D. Student"=>51, "Student > Postgraduate"=>5, "Other"=>11, "Student > Master"=>15, "Student > Bachelor"=>11, "Lecturer"=>1, "Lecturer > Senior Lecturer"=>1, "Professor"=>10}, "reader_count_by_subject_area"=>{"Unspecified"=>3, "Agricultural and Biological Sciences"=>88, "Arts and Humanities"=>2, "Chemistry"=>3, "Computer Science"=>22, "Engineering"=>4, "Environmental Science"=>1, "Biochemistry, Genetics and Molecular Biology"=>23, "Mathematics"=>2, "Medicine and Dentistry"=>19, "Pharmacology, Toxicology and Pharmaceutical Science"=>1, "Psychology"=>2, "Immunology and Microbiology"=>2}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>19}, "Psychology"=>{"Psychology"=>2}, "Mathematics"=>{"Mathematics"=>2}, "Unspecified"=>{"Unspecified"=>3}, "Environmental Science"=>{"Environmental Science"=>1}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>1}, "Arts and Humanities"=>{"Arts and Humanities"=>2}, "Engineering"=>{"Engineering"=>4}, "Chemistry"=>{"Chemistry"=>3}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>2}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>88}, "Computer Science"=>{"Computer Science"=>22}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>23}}, "reader_count_by_country"=>{"United States"=>8, "United Kingdom"=>5, "Spain"=>3, "India"=>1, "Russia"=>1, "Netherlands"=>1, "Sweden"=>1, "Korea (South)"=>1, "China"=>1, "Brazil"=>5, "Italy"=>2, "France"=>2, "Nigeria"=>1, "Australia"=>1, "Germany"=>2}, "group_count"=>5}

Scopus | Further Information

{"@_fa"=>"true", "link"=>[{"@_fa"=>"true", "@ref"=>"self", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/84872040514"}, {"@_fa"=>"true", "@ref"=>"author-affiliation", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/84872040514?field=author,affiliation"}, {"@_fa"=>"true", "@ref"=>"scopus", "@href"=>"https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84872040514&origin=inward"}, {"@_fa"=>"true", "@ref"=>"scopus-citedby", "@href"=>"https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=84872040514&origin=inward"}], "prism:url"=>"https://api.elsevier.com/content/abstract/scopus_id/84872040514", "dc:identifier"=>"SCOPUS_ID:84872040514", "eid"=>"2-s2.0-84872040514", "dc:title"=>"Chapter 6: Structural Variation and Medical Genomics", "dc:creator"=>"Raphael B.", "prism:publicationName"=>"PLoS Computational Biology", "prism:issn"=>"1553734X", "prism:eIssn"=>"15537358", "prism:volume"=>"8", "prism:issueIdentifier"=>"12", "prism:pageRange"=>nil, "prism:coverDate"=>"2012-12-01", "prism:coverDisplayDate"=>"December 2012", "prism:doi"=>"10.1371/journal.pcbi.1002821", "citedby-count"=>"17", "affiliation"=>[{"@_fa"=>"true", "affilname"=>"Brown University", "affiliation-city"=>"Providence", "affiliation-country"=>"United States"}], "pubmed-id"=>"23300412", "prism:aggregationType"=>"Journal", "subtype"=>"ar", "subtypeDescription"=>"Article", "article-number"=>"e1002821", "source-id"=>"4000151810", "openaccess"=>"1", "openaccessFlag"=>true}

Facebook

  • {"url"=>"http%3A%2F%2Fjournals.plos.org%2Fploscompbiol%2Farticle%3Fid%3D10.1371%252Fjournal.pcbi.1002821", "share_count"=>0, "like_count"=>0, "comment_count"=>0, "click_count"=>0, "total_count"=>0}

Counter

  • {"month"=>"12", "year"=>"2012", "pdf_views"=>"159", "xml_views"=>"10", "html_views"=>"453"}
  • {"month"=>"1", "year"=>"2013", "pdf_views"=>"355", "xml_views"=>"8", "html_views"=>"1094"}
  • {"month"=>"2", "year"=>"2013", "pdf_views"=>"132", "xml_views"=>"7", "html_views"=>"751"}
  • {"month"=>"3", "year"=>"2013", "pdf_views"=>"97", "xml_views"=>"2", "html_views"=>"435"}
  • {"month"=>"4", "year"=>"2013", "pdf_views"=>"104", "xml_views"=>"2", "html_views"=>"434"}
  • {"month"=>"5", "year"=>"2013", "pdf_views"=>"85", "xml_views"=>"0", "html_views"=>"337"}
  • {"month"=>"6", "year"=>"2013", "pdf_views"=>"57", "xml_views"=>"0", "html_views"=>"257"}
  • {"month"=>"7", "year"=>"2013", "pdf_views"=>"57", "xml_views"=>"0", "html_views"=>"271"}
  • {"month"=>"8", "year"=>"2013", "pdf_views"=>"47", "xml_views"=>"0", "html_views"=>"231"}
  • {"month"=>"9", "year"=>"2013", "pdf_views"=>"39", "xml_views"=>"3", "html_views"=>"243"}
  • {"month"=>"10", "year"=>"2013", "pdf_views"=>"55", "xml_views"=>"2", "html_views"=>"289"}
  • {"month"=>"11", "year"=>"2013", "pdf_views"=>"48", "xml_views"=>"1", "html_views"=>"238"}
  • {"month"=>"12", "year"=>"2013", "pdf_views"=>"41", "xml_views"=>"1", "html_views"=>"280"}
  • {"month"=>"1", "year"=>"2014", "pdf_views"=>"43", "xml_views"=>"0", "html_views"=>"272"}
  • {"month"=>"2", "year"=>"2014", "pdf_views"=>"57", "xml_views"=>"0", "html_views"=>"289"}
  • {"month"=>"3", "year"=>"2014", "pdf_views"=>"45", "xml_views"=>"5", "html_views"=>"295"}
  • {"month"=>"4", "year"=>"2014", "pdf_views"=>"52", "xml_views"=>"1", "html_views"=>"282"}
  • {"month"=>"5", "year"=>"2014", "pdf_views"=>"51", "xml_views"=>"0", "html_views"=>"260"}
  • {"month"=>"6", "year"=>"2014", "pdf_views"=>"39", "xml_views"=>"0", "html_views"=>"216"}
  • {"month"=>"7", "year"=>"2014", "pdf_views"=>"40", "xml_views"=>"0", "html_views"=>"257"}
  • {"month"=>"8", "year"=>"2014", "pdf_views"=>"29", "xml_views"=>"0", "html_views"=>"195"}
  • {"month"=>"9", "year"=>"2014", "pdf_views"=>"40", "xml_views"=>"0", "html_views"=>"260"}
  • {"month"=>"10", "year"=>"2014", "pdf_views"=>"47", "xml_views"=>"0", "html_views"=>"357"}
  • {"month"=>"11", "year"=>"2014", "pdf_views"=>"38", "xml_views"=>"0", "html_views"=>"330"}
  • {"month"=>"12", "year"=>"2014", "pdf_views"=>"36", "xml_views"=>"0", "html_views"=>"196"}
  • {"month"=>"1", "year"=>"2015", "pdf_views"=>"21", "xml_views"=>"0", "html_views"=>"169"}
  • {"month"=>"2", "year"=>"2015", "pdf_views"=>"33", "xml_views"=>"0", "html_views"=>"154"}
  • {"month"=>"3", "year"=>"2015", "pdf_views"=>"23", "xml_views"=>"0", "html_views"=>"173"}
  • {"month"=>"4", "year"=>"2015", "pdf_views"=>"32", "xml_views"=>"2", "html_views"=>"121"}
  • {"month"=>"5", "year"=>"2015", "pdf_views"=>"30", "xml_views"=>"0", "html_views"=>"109"}
  • {"month"=>"6", "year"=>"2015", "pdf_views"=>"26", "xml_views"=>"0", "html_views"=>"108"}
  • {"month"=>"7", "year"=>"2015", "pdf_views"=>"25", "xml_views"=>"0", "html_views"=>"89"}
  • {"month"=>"8", "year"=>"2015", "pdf_views"=>"19", "xml_views"=>"0", "html_views"=>"117"}
  • {"month"=>"9", "year"=>"2015", "pdf_views"=>"18", "xml_views"=>"0", "html_views"=>"112"}
  • {"month"=>"10", "year"=>"2015", "pdf_views"=>"37", "xml_views"=>"0", "html_views"=>"134"}
  • {"month"=>"11", "year"=>"2015", "pdf_views"=>"24", "xml_views"=>"1", "html_views"=>"156"}
  • {"month"=>"12", "year"=>"2015", "pdf_views"=>"22", "xml_views"=>"0", "html_views"=>"141"}
  • {"month"=>"1", "year"=>"2016", "pdf_views"=>"26", "xml_views"=>"0", "html_views"=>"115"}
  • {"month"=>"2", "year"=>"2016", "pdf_views"=>"32", "xml_views"=>"0", "html_views"=>"130"}
  • {"month"=>"3", "year"=>"2016", "pdf_views"=>"36", "xml_views"=>"0", "html_views"=>"164"}
  • {"month"=>"4", "year"=>"2016", "pdf_views"=>"27", "xml_views"=>"0", "html_views"=>"99"}
  • {"month"=>"5", "year"=>"2016", "pdf_views"=>"32", "xml_views"=>"0", "html_views"=>"114"}
  • {"month"=>"6", "year"=>"2016", "pdf_views"=>"52", "xml_views"=>"0", "html_views"=>"94"}
  • {"month"=>"7", "year"=>"2016", "pdf_views"=>"37", "xml_views"=>"0", "html_views"=>"73"}
  • {"month"=>"8", "year"=>"2016", "pdf_views"=>"18", "xml_views"=>"0", "html_views"=>"92"}
  • {"month"=>"9", "year"=>"2016", "pdf_views"=>"22", "xml_views"=>"0", "html_views"=>"91"}
  • {"month"=>"10", "year"=>"2016", "pdf_views"=>"33", "xml_views"=>"0", "html_views"=>"146"}
  • {"month"=>"11", "year"=>"2016", "pdf_views"=>"17", "xml_views"=>"0", "html_views"=>"170"}
  • {"month"=>"12", "year"=>"2016", "pdf_views"=>"26", "xml_views"=>"0", "html_views"=>"160"}
  • {"month"=>"1", "year"=>"2017", "pdf_views"=>"24", "xml_views"=>"0", "html_views"=>"104"}
  • {"month"=>"2", "year"=>"2017", "pdf_views"=>"25", "xml_views"=>"0", "html_views"=>"121"}
  • {"month"=>"3", "year"=>"2017", "pdf_views"=>"34", "xml_views"=>"1", "html_views"=>"206"}
  • {"month"=>"4", "year"=>"2017", "pdf_views"=>"27", "xml_views"=>"1", "html_views"=>"133"}
  • {"month"=>"5", "year"=>"2017", "pdf_views"=>"26", "xml_views"=>"1", "html_views"=>"208"}
  • {"month"=>"6", "year"=>"2017", "pdf_views"=>"15", "xml_views"=>"0", "html_views"=>"239"}
  • {"month"=>"7", "year"=>"2017", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"220"}
  • {"month"=>"8", "year"=>"2017", "pdf_views"=>"16", "xml_views"=>"1", "html_views"=>"181"}
  • {"month"=>"9", "year"=>"2017", "pdf_views"=>"15", "xml_views"=>"1", "html_views"=>"102"}
  • {"month"=>"10", "year"=>"2017", "pdf_views"=>"27", "xml_views"=>"1", "html_views"=>"102"}
  • {"month"=>"11", "year"=>"2017", "pdf_views"=>"17", "xml_views"=>"1", "html_views"=>"98"}
  • {"month"=>"12", "year"=>"2017", "pdf_views"=>"17", "xml_views"=>"1", "html_views"=>"79"}
  • {"month"=>"1", "year"=>"2018", "pdf_views"=>"24", "xml_views"=>"1", "html_views"=>"74"}
  • {"month"=>"2", "year"=>"2018", "pdf_views"=>"16", "xml_views"=>"0", "html_views"=>"31"}
  • {"month"=>"3", "year"=>"2018", "pdf_views"=>"45", "xml_views"=>"0", "html_views"=>"80"}
  • {"month"=>"4", "year"=>"2018", "pdf_views"=>"31", "xml_views"=>"0", "html_views"=>"49"}
  • {"month"=>"5", "year"=>"2018", "pdf_views"=>"23", "xml_views"=>"2", "html_views"=>"51"}
  • {"month"=>"6", "year"=>"2018", "pdf_views"=>"16", "xml_views"=>"0", "html_views"=>"46"}
  • {"month"=>"7", "year"=>"2018", "pdf_views"=>"31", "xml_views"=>"0", "html_views"=>"45"}
  • {"month"=>"8", "year"=>"2018", "pdf_views"=>"35", "xml_views"=>"1", "html_views"=>"89"}
  • {"month"=>"9", "year"=>"2018", "pdf_views"=>"24", "xml_views"=>"0", "html_views"=>"48"}
  • {"month"=>"10", "year"=>"2018", "pdf_views"=>"41", "xml_views"=>"1", "html_views"=>"59"}
  • {"month"=>"11", "year"=>"2018", "pdf_views"=>"18", "xml_views"=>"1", "html_views"=>"54"}
  • {"month"=>"12", "year"=>"2018", "pdf_views"=>"27", "xml_views"=>"0", "html_views"=>"25"}
  • {"month"=>"1", "year"=>"2019", "pdf_views"=>"19", "xml_views"=>"0", "html_views"=>"35"}
  • {"month"=>"2", "year"=>"2019", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"28"}
  • {"month"=>"3", "year"=>"2019", "pdf_views"=>"17", "xml_views"=>"5", "html_views"=>"40"}
  • {"month"=>"4", "year"=>"2019", "pdf_views"=>"22", "xml_views"=>"1", "html_views"=>"56"}
  • {"month"=>"5", "year"=>"2019", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"35"}
  • {"month"=>"6", "year"=>"2019", "pdf_views"=>"16", "xml_views"=>"0", "html_views"=>"31"}
  • {"month"=>"7", "year"=>"2019", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"19"}

Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/515988"], "description"=>"<p>The inversion flips the orientation of the subsequence, or block, in one genome relative to the other genome.</p>", "links"=>[], "tags"=>["inversion", "resulting", "non-allelic", "homologous", "recombination", "segmental", "duplications", "orientations"], "article_id"=>186476, "categories"=>["Biological Sciences", "Genetics"], "users"=>["Benjamin J. Raphael"], "doi"=>"https://dx.doi.org/10.1371/journal.pcbi.1002821.g001", "stats"=>{"downloads"=>8, "page_views"=>12, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_An_inversion_resulting_from_non_allelic_homologous_recombination_NAHR_between_two_nearly_identical_segmental_duplications_blue_boxes_with_opposite_orientations_arrows_/186476", "title"=>"An inversion resulting from non-allelic homologous recombination (NAHR) between two nearly identical segmental duplications (blue boxes) with opposite orientations (arrows).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2012-12-27 01:47:56"}
  • {"files"=>["https://ndownloader.figshare.com/files/516060"], "description"=>"<p>In <i>de novo</i> assembly, the individual genome sequence is constructed by examining overlaps between reads. In resequencing approaches, reads from the individual genome are aligned to a closely related reference genome. Examination of the resulting alignments reveals differences between the individual genome and the reference genome.</p>", "links"=>[], "tags"=>["approaches", "variants", "genome", "next-generation", "sequencing"], "article_id"=>186557, "categories"=>["Biological Sciences", "Genetics"], "users"=>["Benjamin J. Raphael"], "doi"=>"https://dx.doi.org/10.1371/journal.pcbi.1002821.g002", "stats"=>{"downloads"=>1, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Two_major_approaches_to_detect_structural_variants_in_an_individual_genome_from_next_generation_sequencing_data_are_de_novo_assembly_and_resequencing_/186557", "title"=>"Two major approaches to detect structural variants in an individual genome from next-generation sequencing data are <i>de novo</i> assembly and resequencing.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2012-12-27 01:49:17"}
  • {"files"=>["https://ndownloader.figshare.com/files/516372"], "description"=>"<p>(Top) A discordant pair (arc) indicates a deletion with unknown breakpoints and located in orange blocks. Positions , and the minimum and maximum length of end-sequenced fragments constrain breakpoints to lie within the indicated orange blocks, and are governed by the indicated linear inequalities. (Bottom) A polygon in 2D genome space expresses the linear dependency between breakpoints and and records the uncertainty in the location of the breakpoints.</p>", "links"=>[], "tags"=>["genetics and genomics", "Computational biology"], "article_id"=>186869, "categories"=>["Biological Sciences", "Genetics"], "users"=>["Benjamin J. Raphael"], "doi"=>"https://dx.doi.org/10.1371/journal.pcbi.1002821.g006", "stats"=>{"downloads"=>0, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Figure_6_/186869", "title"=>"Figure 6", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2012-12-27 01:54:29"}
  • {"files"=>["https://ndownloader.figshare.com/files/516178"], "description"=>"<p>Identification of a deletion in an individual genome by split read analysis (middle), and by depth of coverage analysis (bottom).</p>", "links"=>[], "tags"=>["deletion", "genome"], "article_id"=>186685, "categories"=>["Biological Sciences", "Genetics"], "users"=>["Benjamin J. Raphael"], "doi"=>"https://dx.doi.org/10.1371/journal.pcbi.1002821.g004", "stats"=>{"downloads"=>6, "page_views"=>299, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Identification_of_a_deletion_in_an_individual_genome_by_split_read_analysis_middle_and_by_depth_of_coverage_analysis_bottom_/186685", "title"=>"Identification of a deletion in an individual genome by split read analysis (middle), and by depth of coverage analysis (bottom).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2012-12-27 01:51:25"}
  • {"files"=>["https://ndownloader.figshare.com/files/516130"], "description"=>"<p>A strobe with 3 subreads.</p>", "links"=>[], "tags"=>["strobe"], "article_id"=>186635, "categories"=>["Biological Sciences", "Genetics"], "users"=>["Benjamin J. Raphael"], "doi"=>"https://dx.doi.org/10.1371/journal.pcbi.1002821.g003", "stats"=>{"downloads"=>5, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_A_strobe_with_3_subreads_/186635", "title"=>"A strobe with 3 subreads.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2012-12-27 01:50:35"}
  • {"files"=>["https://ndownloader.figshare.com/files/516304"], "description"=>"<p>Fragments from an individual genome are sequenced from both ends and the resulting paired reads are aligned to a reference genome. Most paired reads correspond to concordant pairs, where the distance between the alignment of each read agrees with the distribution of fragment lengths (right). The remaining discordant pairs suggest structural variants (here a deletion) that distinguish the individual and reference genomes.</p>", "links"=>[], "tags"=>["genetics and genomics", "Computational biology"], "article_id"=>186807, "categories"=>["Biological Sciences", "Genetics"], "users"=>["Benjamin J. Raphael"], "doi"=>"https://dx.doi.org/10.1371/journal.pcbi.1002821.g005", "stats"=>{"downloads"=>3, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Paired_end_mapping_PEM_/186807", "title"=>"Paired end mapping (PEM).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2012-12-27 01:53:27"}
  • {"files"=>["https://ndownloader.figshare.com/files/280765"], "description"=>"<div><p>Differences between individual human genomes, or between human and cancer genomes, range in scale from single nucleotide variants (SNVs) through intermediate and large-scale duplications, deletions, and rearrangements of genomic segments. The latter class, called structural variants (SVs), have received considerable attention in the past several years as they are a previously under appreciated source of variation in human genomes. Much of this recent attention is the result of the availability of higher-resolution technologies for measuring these variants, including both microarray-based techniques, and more recently, high-throughput DNA sequencing. We describe the genomic technologies and computational techniques currently used to measure SVs, focusing on applications in human and cancer genomics.</p> </div>", "links"=>[], "tags"=>["genomics"], "article_id"=>115372, "categories"=>["Biological Sciences", "Genetics"], "users"=>["Benjamin J. Raphael"], "doi"=>"https://dx.doi.org/10.1371/journal.pcbi.1002821", "stats"=>{"downloads"=>16, "page_views"=>41, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Chapter_6_Structural_Variation_and_Medical_Genomics_/115372", "title"=>"Chapter 6: Structural Variation and Medical Genomics", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2012-12-27 01:29:32"}
  • {"files"=>["https://ndownloader.figshare.com/files/516439"], "description"=>"<p>Current DNA sequencing approaches sequence DNA from many cells and thus result in a heterogenous mixture of mutations, with varying numbers of both passenger mutations (black) and driver mutations (red).</p>", "links"=>[], "tags"=>["clonal", "leads", "genomic", "heterogeneity", "cells"], "article_id"=>186934, "categories"=>["Biological Sciences", "Genetics"], "users"=>["Benjamin J. Raphael"], "doi"=>"https://dx.doi.org/10.1371/journal.pcbi.1002821.g007", "stats"=>{"downloads"=>2, "page_views"=>19, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Mutation_selection_and_clonal_expansion_in_tumor_development_leads_to_genomic_heterogeneity_between_cells_in_a_tumor_/186934", "title"=>"Mutation, selection, and clonal expansion in tumor development leads to genomic heterogeneity between cells in a tumor.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2012-12-27 01:55:34"}

PMC Usage Stats | Further Information

  • {"unique-ip"=>"34", "full-text"=>"31", "pdf"=>"16", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"1"}
  • {"unique-ip"=>"39", "full-text"=>"43", "pdf"=>"12", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"2"}
  • {"unique-ip"=>"36", "full-text"=>"42", "pdf"=>"11", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2013", "month"=>"3"}
  • {"unique-ip"=>"16", "full-text"=>"16", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2013", "month"=>"4"}
  • {"unique-ip"=>"28", "full-text"=>"26", "pdf"=>"10", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"14", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2013", "month"=>"5"}
  • {"unique-ip"=>"12", "full-text"=>"13", "pdf"=>"27", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"6"}
  • {"unique-ip"=>"23", "full-text"=>"22", "pdf"=>"19", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"7"}
  • {"unique-ip"=>"13", "full-text"=>"15", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2013", "month"=>"8"}
  • {"unique-ip"=>"10", "full-text"=>"9", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"9"}
  • {"unique-ip"=>"5", "full-text"=>"4", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"10"}
  • {"unique-ip"=>"10", "full-text"=>"11", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"11"}
  • {"unique-ip"=>"3", "full-text"=>"2", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"12"}
  • {"unique-ip"=>"11", "full-text"=>"5", "pdf"=>"10", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"1"}
  • {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"2"}
  • {"unique-ip"=>"5", "full-text"=>"3", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"3"}
  • {"unique-ip"=>"7", "full-text"=>"8", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"5"}
  • {"unique-ip"=>"10", "full-text"=>"9", "pdf"=>"3", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"6"}
  • {"unique-ip"=>"12", "full-text"=>"10", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"4"}
  • {"unique-ip"=>"7", "full-text"=>"6", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"7"}
  • {"unique-ip"=>"8", "full-text"=>"12", "pdf"=>"3", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"8"}
  • {"unique-ip"=>"13", "full-text"=>"10", "pdf"=>"10", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2014", "month"=>"9"}
  • {"unique-ip"=>"15", "full-text"=>"13", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2014", "month"=>"10"}
  • {"unique-ip"=>"17", "full-text"=>"13", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2014", "month"=>"11"}
  • {"unique-ip"=>"11", "full-text"=>"10", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2014", "month"=>"12"}
  • {"unique-ip"=>"12", "full-text"=>"10", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"1"}
  • {"unique-ip"=>"8", "full-text"=>"6", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2015", "month"=>"2"}
  • {"unique-ip"=>"9", "full-text"=>"9", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2015", "month"=>"3"}
  • {"unique-ip"=>"15", "full-text"=>"10", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"4"}
  • {"unique-ip"=>"5", "full-text"=>"5", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"5"}
  • {"unique-ip"=>"11", "full-text"=>"12", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"6"}
  • {"unique-ip"=>"11", "full-text"=>"10", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"7"}
  • {"unique-ip"=>"13", "full-text"=>"13", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"8"}
  • {"unique-ip"=>"11", "full-text"=>"11", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2015", "month"=>"9"}
  • {"unique-ip"=>"14", "full-text"=>"15", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"10"}
  • {"unique-ip"=>"22", "full-text"=>"22", "pdf"=>"14", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2015", "month"=>"11"}
  • {"unique-ip"=>"10", "full-text"=>"8", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"12"}
  • {"unique-ip"=>"12", "full-text"=>"12", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"1"}
  • {"unique-ip"=>"7", "full-text"=>"9", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"2"}
  • {"unique-ip"=>"15", "full-text"=>"12", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2016", "month"=>"4"}
  • {"unique-ip"=>"13", "full-text"=>"12", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"3"}
  • {"unique-ip"=>"11", "full-text"=>"20", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"5"}
  • {"unique-ip"=>"8", "full-text"=>"9", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2016", "month"=>"6"}
  • {"unique-ip"=>"8", "full-text"=>"8", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"7"}
  • {"unique-ip"=>"4", "full-text"=>"3", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"8"}
  • {"unique-ip"=>"8", "full-text"=>"5", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"9"}
  • {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"10"}
  • {"unique-ip"=>"16", "full-text"=>"17", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"11"}
  • {"unique-ip"=>"12", "full-text"=>"12", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"2", "cited-by"=>"3", "year"=>"2016", "month"=>"12"}
  • {"unique-ip"=>"12", "full-text"=>"11", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2017", "month"=>"1"}
  • {"unique-ip"=>"6", "full-text"=>"4", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"2"}
  • {"unique-ip"=>"13", "full-text"=>"15", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"3"}
  • {"unique-ip"=>"8", "full-text"=>"9", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2017", "month"=>"4"}
  • {"unique-ip"=>"10", "full-text"=>"9", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"5"}
  • {"unique-ip"=>"9", "full-text"=>"10", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"6"}
  • {"unique-ip"=>"12", "full-text"=>"15", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"7"}
  • {"unique-ip"=>"13", "full-text"=>"17", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"8"}
  • {"unique-ip"=>"14", "full-text"=>"12", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2017", "month"=>"9"}
  • {"unique-ip"=>"8", "full-text"=>"6", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"10"}
  • {"unique-ip"=>"3", "full-text"=>"2", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"11"}
  • {"unique-ip"=>"4", "full-text"=>"3", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"12"}
  • {"unique-ip"=>"12", "full-text"=>"14", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"1"}
  • {"unique-ip"=>"8", "full-text"=>"8", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"3"}
  • {"unique-ip"=>"9", "full-text"=>"10", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"1"}
  • {"unique-ip"=>"23", "full-text"=>"16", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"4"}
  • {"unique-ip"=>"9", "full-text"=>"10", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"5"}
  • {"unique-ip"=>"13", "full-text"=>"16", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2018", "month"=>"6"}
  • {"unique-ip"=>"10", "full-text"=>"12", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"7"}
  • {"unique-ip"=>"12", "full-text"=>"12", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2018", "month"=>"8"}
  • {"unique-ip"=>"10", "full-text"=>"10", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"9"}
  • {"unique-ip"=>"12", "full-text"=>"12", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"10"}
  • {"unique-ip"=>"8", "full-text"=>"7", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2018", "month"=>"11"}
  • {"unique-ip"=>"9", "full-text"=>"10", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"12"}
  • {"unique-ip"=>"8", "full-text"=>"9", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2019", "month"=>"2"}
  • {"unique-ip"=>"6", "full-text"=>"6", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"3"}
  • {"unique-ip"=>"11", "full-text"=>"9", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"4"}
  • {"unique-ip"=>"6", "full-text"=>"8", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"5"}

Relative Metric

{"start_date"=>"2012-01-01T00:00:00Z", "end_date"=>"2012-12-31T00:00:00Z", "subject_areas"=>[{"subject_area"=>"/Biology and life sciences/Computational biology", "average_usage"=>[375, 629, 760, 889, 1000, 1110, 1203, 1298, 1399, 1492, 1603, 1699, 1774, 1855, 1918, 1998, 2062, 2152, 2227, 2312, 2378, 2461, 2528, 2600, 2664]}, {"subject_area"=>"/Biology and life sciences/Genetics", "average_usage"=>[333, 576, 707, 814, 908, 1004, 1104, 1197, 1280, 1370, 1449, 1531, 1603, 1673, 1742, 1817, 1886, 1954, 2025, 2098, 2171, 2234, 2304, 2365, 2431]}, {"subject_area"=>"/Biology and life sciences/Molecular biology", "average_usage"=>[324, 551, 679, 782, 879, 971, 1064, 1154, 1245, 1328, 1406, 1476, 1541, 1617, 1683, 1754, 1818, 1893, 1962, 2025, 2092, 2164, 2227, 2294, 2355]}]}
Loading … Spinner
There are currently no alerts