Amino Acid Changes in Disease-Associated Variants Differ Radically from Variants Observed in the 1000 Genomes Project Dataset
Events
Loading … Spinner

CiteULike | Further Information

Mendeley | Further Information

{"title"=>"Amino Acid Changes in Disease-Associated Variants Differ Radically from Variants Observed in the 1000 Genomes Project Dataset", "type"=>"journal", "authors"=>[{"first_name"=>"Tjaart A.P.", "last_name"=>"de Beer", "scopus_author_id"=>"13409396700"}, {"first_name"=>"Roman A.", "last_name"=>"Laskowski", "scopus_author_id"=>"7007150966"}, {"first_name"=>"Sarah L.", "last_name"=>"Parks", "scopus_author_id"=>"56010567500"}, {"first_name"=>"Botond", "last_name"=>"Sipos", "scopus_author_id"=>"23986384900"}, {"first_name"=>"Nick", "last_name"=>"Goldman", "scopus_author_id"=>"35352621700"}, {"first_name"=>"Janet M.", "last_name"=>"Thornton", "scopus_author_id"=>"7402781853"}], "year"=>2013, "source"=>"PLoS Computational Biology", "identifiers"=>{"pui"=>"372170448", "sgr"=>"84892739749", "issn"=>"1553734X", "pmid"=>"24348229", "scopus"=>"2-s2.0-84892739749", "doi"=>"10.1371/journal.pcbi.1003382", "isbn"=>"1553-7358 (Electronic)\\r1553-734X (Linking)"}, "id"=>"dc82ee55-2bd9-3028-9db6-334e97ba91e8", "abstract"=>"The 1000 Genomes Project data provides a natural background dataset for amino acid germline mutations in humans. Since the direction of mutation is known, the amino acid exchange matrix generated from the observed nucleotide variants is asymmetric and the mutabilities of the different amino acids are very different. These differences predominantly reflect preferences for nucleotide mutations in the DNA (especially the high mutation rate of the CpG dinucleotide, which makes arginine mutability very much higher than other amino acids) rather than selection imposed by protein structure constraints, although there is evidence for the latter as well. The variants occur predominantly on the surface of proteins (82%), with a slight preference for sites which are more exposed and less well conserved than random. Mutations to functional residues occur about half as often as expected by chance. The disease-associated amino acid variant distributions in OMIM are radically different from those expected on the basis of the 1000 Genomes dataset. The disease-associated variants preferentially occur in more conserved sites, compared to 1000 Genomes mutations. Many of the amino acid exchange profiles appear to exhibit an anti-correlation, with common exchanges in one dataset being rare in the other. Disease-associated variants exhibit more extreme differences in amino acid size and hydrophobicity. More modelling of the mutational processes at the nucleotide level is needed, but these observations should contribute to an improved prediction of the effects of specific variants in humans.", "link"=>"http://www.mendeley.com/research/amino-acid-changes-diseaseassociated-variants-differ-radically-variants-observed-1000-genomes-projec", "reader_count"=>100, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>8, "Researcher"=>27, "Student > Doctoral Student"=>3, "Student > Ph. D. Student"=>35, "Student > Postgraduate"=>6, "Other"=>5, "Student > Master"=>5, "Student > Bachelor"=>3, "Lecturer"=>1, "Lecturer > Senior Lecturer"=>1, "Professor"=>6}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>8, "Researcher"=>27, "Student > Doctoral Student"=>3, "Student > Ph. D. Student"=>35, "Student > Postgraduate"=>6, "Other"=>5, "Student > Master"=>5, "Student > Bachelor"=>3, "Lecturer"=>1, "Lecturer > Senior Lecturer"=>1, "Professor"=>6}, "reader_count_by_subject_area"=>{"Unspecified"=>1, "Engineering"=>1, "Biochemistry, Genetics and Molecular Biology"=>20, "Materials Science"=>1, "Agricultural and Biological Sciences"=>69, "Medicine and Dentistry"=>2, "Neuroscience"=>1, "Chemistry"=>1, "Computer Science"=>3, "Immunology and Microbiology"=>1}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>1}, "Materials Science"=>{"Materials Science"=>1}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>2}, "Neuroscience"=>{"Neuroscience"=>1}, "Chemistry"=>{"Chemistry"=>1}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>69}, "Computer Science"=>{"Computer Science"=>3}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>20}, "Unspecified"=>{"Unspecified"=>1}}, "reader_count_by_country"=>{"Canada"=>1, "Austria"=>1, "Netherlands"=>2, "Sweden"=>1, "United States"=>5, "Sri Lanka"=>1, "United Kingdom"=>4, "Switzerland"=>1, "Germany"=>1, "Spain"=>2}, "group_count"=>4}

Scopus | Further Information

{"@_fa"=>"true", "link"=>[{"@_fa"=>"true", "@ref"=>"self", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/84892739749"}, {"@_fa"=>"true", "@ref"=>"author-affiliation", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/84892739749?field=author,affiliation"}, {"@_fa"=>"true", "@ref"=>"scopus", "@href"=>"https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84892739749&origin=inward"}, {"@_fa"=>"true", "@ref"=>"scopus-citedby", "@href"=>"https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=84892739749&origin=inward"}], "prism:url"=>"https://api.elsevier.com/content/abstract/scopus_id/84892739749", "dc:identifier"=>"SCOPUS_ID:84892739749", "eid"=>"2-s2.0-84892739749", "dc:title"=>"Amino Acid Changes in Disease-Associated Variants Differ Radically from Variants Observed in the 1000 Genomes Project Dataset", "dc:creator"=>"de Beer T.", "prism:publicationName"=>"PLoS Computational Biology", "prism:issn"=>"1553734X", "prism:eIssn"=>"15537358", "prism:volume"=>"9", "prism:issueIdentifier"=>"12", "prism:pageRange"=>nil, "prism:coverDate"=>"2013-12-01", "prism:coverDisplayDate"=>"December 2013", "prism:doi"=>"10.1371/journal.pcbi.1003382", "citedby-count"=>"36", "affiliation"=>[{"@_fa"=>"true", "affilname"=>"European Bioinformatics Institute", "affiliation-city"=>"Cambridge", "affiliation-country"=>"United Kingdom"}], "pubmed-id"=>"24348229", "prism:aggregationType"=>"Journal", "subtype"=>"ar", "subtypeDescription"=>"Article", "article-number"=>"e1003382", "source-id"=>"4000151810", "openaccess"=>"1", "openaccessFlag"=>true}

Facebook

  • {"url"=>"http%3A%2F%2Fjournals.plos.org%2Fploscompbiol%2Farticle%3Fid%3D10.1371%252Fjournal.pcbi.1003382", "share_count"=>0, "like_count"=>0, "comment_count"=>0, "click_count"=>0, "total_count"=>0}

Twitter

Counter

  • {"month"=>"12", "year"=>"2013", "pdf_views"=>"224", "xml_views"=>"15", "html_views"=>"1423"}
  • {"month"=>"1", "year"=>"2014", "pdf_views"=>"113", "xml_views"=>"3", "html_views"=>"1029"}
  • {"month"=>"2", "year"=>"2014", "pdf_views"=>"51", "xml_views"=>"0", "html_views"=>"326"}
  • {"month"=>"3", "year"=>"2014", "pdf_views"=>"38", "xml_views"=>"1", "html_views"=>"359"}
  • {"month"=>"4", "year"=>"2014", "pdf_views"=>"28", "xml_views"=>"3", "html_views"=>"338"}
  • {"month"=>"5", "year"=>"2014", "pdf_views"=>"221", "xml_views"=>"0", "html_views"=>"339"}
  • {"month"=>"6", "year"=>"2014", "pdf_views"=>"37", "xml_views"=>"0", "html_views"=>"402"}
  • {"month"=>"7", "year"=>"2014", "pdf_views"=>"24", "xml_views"=>"0", "html_views"=>"324"}
  • {"month"=>"8", "year"=>"2014", "pdf_views"=>"24", "xml_views"=>"3", "html_views"=>"294"}
  • {"month"=>"9", "year"=>"2014", "pdf_views"=>"28", "xml_views"=>"1", "html_views"=>"361"}
  • {"month"=>"10", "year"=>"2014", "pdf_views"=>"25", "xml_views"=>"1", "html_views"=>"300"}
  • {"month"=>"11", "year"=>"2014", "pdf_views"=>"10", "xml_views"=>"1", "html_views"=>"260"}
  • {"month"=>"12", "year"=>"2014", "pdf_views"=>"16", "xml_views"=>"2", "html_views"=>"181"}
  • {"month"=>"1", "year"=>"2015", "pdf_views"=>"19", "xml_views"=>"0", "html_views"=>"105"}
  • {"month"=>"2", "year"=>"2015", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"110"}
  • {"month"=>"3", "year"=>"2015", "pdf_views"=>"14", "xml_views"=>"0", "html_views"=>"139"}
  • {"month"=>"4", "year"=>"2015", "pdf_views"=>"9", "xml_views"=>"1", "html_views"=>"167"}
  • {"month"=>"5", "year"=>"2015", "pdf_views"=>"17", "xml_views"=>"0", "html_views"=>"225"}
  • {"month"=>"6", "year"=>"2015", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"104"}
  • {"month"=>"7", "year"=>"2015", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"93"}
  • {"month"=>"8", "year"=>"2015", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"69"}
  • {"month"=>"9", "year"=>"2015", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"118"}
  • {"month"=>"10", "year"=>"2015", "pdf_views"=>"14", "xml_views"=>"0", "html_views"=>"77"}
  • {"month"=>"11", "year"=>"2015", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"63"}
  • {"month"=>"12", "year"=>"2015", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"94"}
  • {"month"=>"1", "year"=>"2016", "pdf_views"=>"17", "xml_views"=>"0", "html_views"=>"123"}
  • {"month"=>"2", "year"=>"2016", "pdf_views"=>"14", "xml_views"=>"0", "html_views"=>"74"}
  • {"month"=>"3", "year"=>"2016", "pdf_views"=>"15", "xml_views"=>"0", "html_views"=>"65"}
  • {"month"=>"4", "year"=>"2016", "pdf_views"=>"18", "xml_views"=>"0", "html_views"=>"77"}
  • {"month"=>"5", "year"=>"2016", "pdf_views"=>"14", "xml_views"=>"0", "html_views"=>"91"}
  • {"month"=>"6", "year"=>"2016", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"51"}
  • {"month"=>"7", "year"=>"2016", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"78"}
  • {"month"=>"8", "year"=>"2016", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"54"}
  • {"month"=>"9", "year"=>"2016", "pdf_views"=>"15", "xml_views"=>"0", "html_views"=>"61"}
  • {"month"=>"10", "year"=>"2016", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"45"}
  • {"month"=>"11", "year"=>"2016", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"37"}
  • {"month"=>"12", "year"=>"2016", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"34"}
  • {"month"=>"1", "year"=>"2017", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"39"}
  • {"month"=>"2", "year"=>"2017", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"72"}
  • {"month"=>"3", "year"=>"2017", "pdf_views"=>"19", "xml_views"=>"0", "html_views"=>"78"}
  • {"month"=>"4", "year"=>"2017", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"46"}
  • {"month"=>"5", "year"=>"2017", "pdf_views"=>"7", "xml_views"=>"1", "html_views"=>"66"}
  • {"month"=>"6", "year"=>"2017", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"60"}
  • {"month"=>"7", "year"=>"2017", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"24"}
  • {"month"=>"8", "year"=>"2017", "pdf_views"=>"7", "xml_views"=>"1", "html_views"=>"43"}
  • {"month"=>"9", "year"=>"2017", "pdf_views"=>"15", "xml_views"=>"1", "html_views"=>"56"}
  • {"month"=>"10", "year"=>"2017", "pdf_views"=>"6", "xml_views"=>"2", "html_views"=>"48"}
  • {"month"=>"11", "year"=>"2017", "pdf_views"=>"2", "xml_views"=>"1", "html_views"=>"43"}
  • {"month"=>"12", "year"=>"2017", "pdf_views"=>"8", "xml_views"=>"1", "html_views"=>"50"}
  • {"month"=>"1", "year"=>"2018", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"32"}
  • {"month"=>"2", "year"=>"2018", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"21"}
  • {"month"=>"3", "year"=>"2018", "pdf_views"=>"11", "xml_views"=>"1", "html_views"=>"27"}
  • {"month"=>"4", "year"=>"2018", "pdf_views"=>"15", "xml_views"=>"0", "html_views"=>"36"}
  • {"month"=>"5", "year"=>"2018", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"30"}
  • {"month"=>"6", "year"=>"2018", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"20"}
  • {"month"=>"7", "year"=>"2018", "pdf_views"=>"7", "xml_views"=>"3", "html_views"=>"36"}
  • {"month"=>"8", "year"=>"2018", "pdf_views"=>"9", "xml_views"=>"1", "html_views"=>"27"}
  • {"month"=>"9", "year"=>"2018", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"47"}
  • {"month"=>"10", "year"=>"2018", "pdf_views"=>"14", "xml_views"=>"2", "html_views"=>"37"}
  • {"month"=>"11", "year"=>"2018", "pdf_views"=>"7", "xml_views"=>"1", "html_views"=>"18"}
  • {"month"=>"12", "year"=>"2018", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"13"}
  • {"month"=>"1", "year"=>"2019", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"10"}
  • {"month"=>"2", "year"=>"2019", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"17"}
  • {"month"=>"3", "year"=>"2019", "pdf_views"=>"5", "xml_views"=>"3", "html_views"=>"27"}
  • {"month"=>"4", "year"=>"2019", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"18"}
  • {"month"=>"5", "year"=>"2019", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"25"}
  • {"month"=>"6", "year"=>"2019", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"18"}
  • {"month"=>"7", "year"=>"2019", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"16"}
  • {"month"=>"8", "year"=>"2019", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"10"}
  • {"month"=>"9", "year"=>"2019", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"21"}
  • {"month"=>"10", "year"=>"2019", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"14"}
  • {"month"=>"11", "year"=>"2019", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"34"}
  • {"month"=>"12", "year"=>"2019", "pdf_views"=>"13", "xml_views"=>"1", "html_views"=>"19"}
  • {"month"=>"1", "year"=>"2020", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"21"}
  • {"month"=>"2", "year"=>"2020", "pdf_views"=>"5", "xml_views"=>"2", "html_views"=>"19"}
  • {"month"=>"3", "year"=>"2020", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"14"}
  • {"month"=>"4", "year"=>"2020", "pdf_views"=>"40", "xml_views"=>"1", "html_views"=>"29"}
  • {"month"=>"5", "year"=>"2020", "pdf_views"=>"35", "xml_views"=>"0", "html_views"=>"16"}
  • {"month"=>"6", "year"=>"2020", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"17"}
  • {"month"=>"7", "year"=>"2020", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"6"}
  • {"month"=>"8", "year"=>"2020", "pdf_views"=>"18", "xml_views"=>"0", "html_views"=>"15"}
  • {"month"=>"9", "year"=>"2020", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"17"}

Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/1313611"], "description"=>"<p>Plots showing the differences between (A) Modeller DOPE scores for the wild type and mutant model (based on 3D, 10,628 mutations, and Humsavar sets, 21,446 residues), (B) changes in hydrophobicity between wild type and mutant in both sets and (C) changes in size between wild type and mutation in both sets.</p>", "links"=>[], "tags"=>["physicochemical", "wildtype", "mutant"], "article_id"=>876621, "categories"=>["Biological Sciences"], "users"=>["Tjaart A. P. de Beer", "Roman A. Laskowski", "Sarah L. Parks", "Botond Sipos", "Nick Goldman", "Janet M. Thornton"], "doi"=>"https://dx.doi.org/10.1371/journal.pcbi.1003382.g008", "stats"=>{"downloads"=>3, "page_views"=>2, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Comparison_between_the_physicochemical_properties_of_the_wildtype_and_the_mutant_models_for_each_of_the_data_sets_/876621", "title"=>"Comparison between the physicochemical properties of the wildtype and the mutant models for each of the data sets.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-12-12 04:26:15"}
  • {"files"=>["https://ndownloader.figshare.com/files/1313604"], "description"=>"<p>The density distribution of residue conservation scores for all the amino acid positions in UniProt (9,532,474 residues, black), 1 kG (185,428 residues, blue), OMIM (8,099 residues, red) and Humsavar (21,446 residues, green). The conservation scores range from 0 for non-conserved residues to 1 for highly conserved residues.</p>", "links"=>[], "tags"=>["scores", "sets"], "article_id"=>876614, "categories"=>["Biological Sciences"], "users"=>["Tjaart A. P. de Beer", "Roman A. Laskowski", "Sarah L. Parks", "Botond Sipos", "Nick Goldman", "Janet M. Thornton"], "doi"=>"https://dx.doi.org/10.1371/journal.pcbi.1003382.g006", "stats"=>{"downloads"=>1, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Comparison_of_the_conservation_scores_in_the_four_sets_used_/876614", "title"=>"Comparison of the conservation scores in the four sets used.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-12-12 04:26:15"}
  • {"files"=>["https://ndownloader.figshare.com/files/1313600"], "description"=>"<p>The plot shows the difference between how often an amino acid mutates vs how often it is mutated to. These are raw counts and also reflect the frequency of occurrence. Each amino acid is coloured according to CpG content. Red: a CpG dinucleotide occurs in its codons; yellow: if one of its codons start with a G (with a C possibly preceding it); blue: no CpG in its codons. The black line indicates the diagonal where ‘mutations to’ equals ‘mutations from’.</p>", "links"=>[], "tags"=>["asymmetry", "kg"], "article_id"=>876611, "categories"=>["Biological Sciences"], "users"=>["Tjaart A. P. de Beer", "Roman A. Laskowski", "Sarah L. Parks", "Botond Sipos", "Nick Goldman", "Janet M. Thornton"], "doi"=>"https://dx.doi.org/10.1371/journal.pcbi.1003382.g004", "stats"=>{"downloads"=>0, "page_views"=>17, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_A_visual_representation_of_the_asymmetry_of_the_1_kG_data_/876611", "title"=>"A visual representation of the asymmetry of the 1 kG data.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-12-12 04:26:15"}
  • {"files"=>["https://ndownloader.figshare.com/files/1313618"], "description"=>"<p>The different datasets constructed and used in this study and their composition.</p>", "links"=>[], "tags"=>["datasets", "constructed"], "article_id"=>876628, "categories"=>["Biological Sciences"], "users"=>["Tjaart A. P. de Beer", "Roman A. Laskowski", "Sarah L. Parks", "Botond Sipos", "Nick Goldman", "Janet M. Thornton"], "doi"=>"https://dx.doi.org/10.1371/journal.pcbi.1003382.t001", "stats"=>{"downloads"=>6, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_The_different_datasets_constructed_and_used_in_this_study_and_their_composition_/876628", "title"=>"The different datasets constructed and used in this study and their composition.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-12-12 04:26:15"}
  • {"files"=>["https://ndownloader.figshare.com/files/1313615"], "description"=>"<p>Rates of change from codons were calculated similarly to the amino acid rate matrix <a href=\"http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1003382#pcbi.1003382-Kosiol1\" target=\"_blank\">[36]</a>, but on a 61 by 61 codon matrix.</p>", "links"=>[], "tags"=>["mutation", "rates", "cpg"], "article_id"=>876625, "categories"=>["Biological Sciences"], "users"=>["Tjaart A. P. de Beer", "Roman A. Laskowski", "Sarah L. Parks", "Botond Sipos", "Nick Goldman", "Janet M. Thornton"], "doi"=>"https://dx.doi.org/10.1371/journal.pcbi.1003382.g010", "stats"=>{"downloads"=>2, "page_views"=>2, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Dependence_of_mutation_rates_on_the_change_in_CpG_status_/876625", "title"=>"Dependence of mutation rates on the change in CpG status.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-12-12 04:26:15"}
  • {"files"=>["https://ndownloader.figshare.com/files/1313599"], "description"=>"<p>Amino acid mutability vs the number of codons in the 1 kG data.</p>", "links"=>[], "tags"=>["mutability", "codons", "kg"], "article_id"=>876610, "categories"=>["Biological Sciences"], "users"=>["Tjaart A. P. de Beer", "Roman A. Laskowski", "Sarah L. Parks", "Botond Sipos", "Nick Goldman", "Janet M. Thornton"], "doi"=>"https://dx.doi.org/10.1371/journal.pcbi.1003382.g003", "stats"=>{"downloads"=>2, "page_views"=>17, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Amino_acid_mutability_vs_the_number_of_codons_in_the_1_kG_data_/876610", "title"=>"Amino acid mutability vs the number of codons in the 1 kG data.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-12-12 04:26:15"}
  • {"files"=>["https://ndownloader.figshare.com/files/1313613"], "description"=>"<p>(A) 1 kG data, (B) PAM matrix and (C) WAG matrix. (D) A PCA (first two components) plot showing the separation of the 1 kG matrices from other matrices. Matrices included are 1 kG (with and without assuming direction), nuclear (WAG, JTT, LG, PAM, tm126, PCMA), mitochondrial (mtREV24, mtMam, mtArt, mtZoa), chloroplast (cpREV, cpREV64), exposed (alpha helix, beta sheet, coil, turn) and buried (alpha helix, beta sheet, coil, turn). Principal components one and two represent 34% and 20% of the variance, respectively. All other principal components represent 9% or less of the variance each. Amino acids are arranged according to increasing hydrophobicity.</p>", "links"=>[], "tags"=>["comparing", "differences", "instantaneous", "matrices"], "article_id"=>876623, "categories"=>["Biological Sciences"], "users"=>["Tjaart A. P. de Beer", "Roman A. Laskowski", "Sarah L. Parks", "Botond Sipos", "Nick Goldman", "Janet M. Thornton"], "doi"=>"https://dx.doi.org/10.1371/journal.pcbi.1003382.g009", "stats"=>{"downloads"=>3, "page_views"=>16, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Bubble_plots_comparing_the_relative_differences_between_the_instantaneous_rate_change_matrices_of_the_data_sets_/876623", "title"=>"Bubble plots comparing the relative differences between the instantaneous rate change matrices of the data sets.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-12-12 04:26:15"}
  • {"files"=>["https://ndownloader.figshare.com/files/1313594"], "description"=>"<p>The 1*. Amino acids are arranged by 1 letter code according to increasing hydrophobicity (least hydrophobic is left and most hydrophobic is right) using the Fauchère and Pliska scale <a href=\"http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1003382#pcbi.1003382-Fauchre1\" target=\"_blank\">[58]</a>. Yellow blocks indicate mutations where there are statistically significant differences between 1 kG and OMIM. Blue blocks indicate where no mutations were present in the 1 kG data set. White blocks show where there are no statistically significant differences. Green blocks show where there are proportionally more 1 kG mutations compared to OMIM. Orange blocks show where there are proportionally more OMIM mutations than 1 kG. The mutability scores (see <a href=\"http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1003382#s4\" target=\"_blank\">methods</a>) for the 1 kG and OMIM sets are shown in the last column. <sup>*</sup>Note that these matrices are fundamentally different. The 1 kG data set gathers all the observed mutations in the 1 kG project, counting each only once; the OMIM data set combines information gathered from potentially many individuals but filtered to identify those mutations associated with a disease.</p>", "links"=>[], "tags"=>["amino", "exchanges", "observed"], "article_id"=>876605, "categories"=>["Biological Sciences"], "users"=>["Tjaart A. P. de Beer", "Roman A. Laskowski", "Sarah L. Parks", "Botond Sipos", "Nick Goldman", "Janet M. Thornton"], "doi"=>"https://dx.doi.org/10.1371/journal.pcbi.1003382.g001", "stats"=>{"downloads"=>0, "page_views"=>2, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_The_amino_acid_exchanges_observed_in_human_protein_variants_/876605", "title"=>"The amino acid exchanges observed in human protein variants.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-12-12 04:26:15"}
  • {"files"=>["https://ndownloader.figshare.com/files/1313626", "https://ndownloader.figshare.com/files/1313628", "https://ndownloader.figshare.com/files/1313629", "https://ndownloader.figshare.com/files/1313630", "https://ndownloader.figshare.com/files/1313631", "https://ndownloader.figshare.com/files/1313632"], "description"=>"<div><p>The 1000 Genomes Project data provides a natural background dataset for amino acid germline mutations in humans. Since the direction of mutation is known, the amino acid exchange matrix generated from the observed nucleotide variants is asymmetric and the mutabilities of the different amino acids are very different. These differences predominantly reflect preferences for nucleotide mutations in the DNA (especially the high mutation rate of the CpG dinucleotide, which makes arginine mutability very much higher than other amino acids) rather than selection imposed by protein structure constraints, although there is evidence for the latter as well. The variants occur predominantly on the surface of proteins (82%), with a slight preference for sites which are more exposed and less well conserved than random. Mutations to functional residues occur about half as often as expected by chance. The disease-associated amino acid variant distributions in OMIM are radically different from those expected on the basis of the 1000 Genomes dataset. The disease-associated variants preferentially occur in more conserved sites, compared to 1000 Genomes mutations. Many of the amino acid exchange profiles appear to exhibit an anti-correlation, with common exchanges in one dataset being rare in the other. Disease-associated variants exhibit more extreme differences in amino acid size and hydrophobicity. More modelling of the mutational processes at the nucleotide level is needed, but these observations should contribute to an improved prediction of the effects of specific variants in humans.</p></div>", "links"=>[], "tags"=>["disease-associated", "variants", "radically", "observed", "1000", "genomes"], "article_id"=>876636, "categories"=>["Biological Sciences"], "users"=>["Tjaart A. P. de Beer", "Roman A. Laskowski", "Sarah L. Parks", "Botond Sipos", "Nick Goldman", "Janet M. Thornton"], "doi"=>["https://dx.doi.org/10.1371/journal.pcbi.1003382.s001", "https://dx.doi.org/10.1371/journal.pcbi.1003382.s002", "https://dx.doi.org/10.1371/journal.pcbi.1003382.s003", "https://dx.doi.org/10.1371/journal.pcbi.1003382.s004", "https://dx.doi.org/10.1371/journal.pcbi.1003382.s005", "https://dx.doi.org/10.1371/journal.pcbi.1003382.s006"], "stats"=>{"downloads"=>7, "page_views"=>21, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Amino_Acid_Changes_in_Disease_Associated_Variants_Differ_Radically_from_Variants_Observed_in_the_1000_Genomes_Project_Dataset_/876636", "title"=>"Amino Acid Changes in Disease-Associated Variants Differ Radically from Variants Observed in the 1000 Genomes Project Dataset", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2013-12-12 04:26:15"}
  • {"files"=>["https://ndownloader.figshare.com/files/1313608"], "description"=>"<p>Comparison of the differences in the % of observed mutations in the 1 kG (blue) and OMIM (red) sets for one amino acid mutating to all others e.g. proportionally, more mutations from Lys to Glu are recorded in OMIM than in the 1 kG set. Each plot shows the results of mutation from a specific amino acid (e.g. Arg at top left) to every other amino acid.</p>", "links"=>[], "tags"=>["differences", "observed", "mutations"], "article_id"=>876618, "categories"=>["Biological Sciences"], "users"=>["Tjaart A. P. de Beer", "Roman A. Laskowski", "Sarah L. Parks", "Botond Sipos", "Nick Goldman", "Janet M. Thornton"], "doi"=>"https://dx.doi.org/10.1371/journal.pcbi.1003382.g007", "stats"=>{"downloads"=>1, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Comparison_of_the_differences_in_observed_mutations_in_the_various_sets_/876618", "title"=>"Comparison of the differences in observed mutations in the various sets.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-12-12 04:26:15"}
  • {"files"=>["https://ndownloader.figshare.com/files/1313617"], "description"=>"<p>‘Site’ refers to residue specific annotations made by depositors of PDB structures, ‘Ligand’ refers to residues involved in binding a ligand, ‘Metal’ refers to residues coordinating with metals and ‘Catalytic’ to residues involved in the catalytic activity of the protein. The % of non-redundant assigned residues that are ‘functional’ is also shown.</p>", "links"=>[], "tags"=>["functions", "assigned", "nssnps"], "article_id"=>876627, "categories"=>["Biological Sciences"], "users"=>["Tjaart A. P. de Beer", "Roman A. Laskowski", "Sarah L. Parks", "Botond Sipos", "Nick Goldman", "Janet M. Thornton"], "doi"=>"https://dx.doi.org/10.1371/journal.pcbi.1003382.t002", "stats"=>{"downloads"=>1, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_The_various_functions_assigned_to_nsSNPs_in_each_set_/876627", "title"=>"The various functions assigned to nsSNPs in each set.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-12-12 04:26:15"}
  • {"files"=>["https://ndownloader.figshare.com/files/1313601"], "description"=>"<p>(A) the solvent accessibility for the variants in the four datasets, (B) the secondary structure in which each of the variants occurs, (C) the functional annotation of every variant in the four datasets.</p>", "links"=>[], "tags"=>["kg", "omim", "nssnps", "humsavar", "3d"], "article_id"=>876612, "categories"=>["Biological Sciences"], "users"=>["Tjaart A. P. de Beer", "Roman A. Laskowski", "Sarah L. Parks", "Botond Sipos", "Nick Goldman", "Janet M. Thornton"], "doi"=>"https://dx.doi.org/10.1371/journal.pcbi.1003382.g005", "stats"=>{"downloads"=>2, "page_views"=>14, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Site_properties_for_all_residues_1_kG_nsSNPs_OMIM_nsSNPs_and_Humsavar_nsSNPs_in_the_structure_3D_set_/876612", "title"=>"Site properties for all residues, 1 kG nsSNPs, OMIM nsSNPs and Humsavar nsSNPs in the structure 3D set.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-12-12 04:26:15"}
  • {"files"=>["https://ndownloader.figshare.com/files/1313598"], "description"=>"<p>Comparison of the number of mutating residues vs the amino acid frequency of occurrence.</p>", "links"=>[], "tags"=>["mutating", "residues", "amino"], "article_id"=>876609, "categories"=>["Biological Sciences"], "users"=>["Tjaart A. P. de Beer", "Roman A. Laskowski", "Sarah L. Parks", "Botond Sipos", "Nick Goldman", "Janet M. Thornton"], "doi"=>"https://dx.doi.org/10.1371/journal.pcbi.1003382.g002", "stats"=>{"downloads"=>1, "page_views"=>2, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Comparison_of_the_number_of_mutating_residues_vs_the_amino_acid_frequency_of_occurrence_/876609", "title"=>"Comparison of the number of mutating residues vs the amino acid frequency of occurrence.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-12-12 04:26:15"}
  • {"files"=>["https://ndownloader.figshare.com/files/1313616"], "description"=>"<p>The most mutable amino acids are at the top. Correlation coefficients for 1 kG vs OMIM, 1 kG vs Humsavar and OMIM vs Humsavar are 0.09, 0.17 and 0.51, respectively.</p>", "links"=>[], "tags"=>["mutability", "comparing", "scores", "omim", "humsavar"], "article_id"=>876626, "categories"=>["Biological Sciences"], "users"=>["Tjaart A. P. de Beer", "Roman A. Laskowski", "Sarah L. Parks", "Botond Sipos", "Nick Goldman", "Janet M. Thornton"], "doi"=>"https://dx.doi.org/10.1371/journal.pcbi.1003382.g011", "stats"=>{"downloads"=>0, "page_views"=>15, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Amino_acid_mutability_rank_order_plot_comparing_the_mutability_scores_for_1_kG_OMIM_and_Humsavar_residues_/876626", "title"=>"Amino acid mutability rank order plot comparing the mutability scores for 1 kG, OMIM and Humsavar residues.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-12-12 04:26:15"}

PMC Usage Stats | Further Information

  • {"unique-ip"=>"9", "full-text"=>"9", "pdf"=>"8", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"12"}
  • {"unique-ip"=>"38", "full-text"=>"35", "pdf"=>"11", "abstract"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"15", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"1"}
  • {"unique-ip"=>"24", "full-text"=>"24", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"18", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"2"}
  • {"unique-ip"=>"10", "full-text"=>"8", "pdf"=>"4", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"3"}
  • {"unique-ip"=>"7", "full-text"=>"8", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2014", "month"=>"5"}
  • {"unique-ip"=>"8", "full-text"=>"8", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"6"}
  • {"unique-ip"=>"16", "full-text"=>"20", "pdf"=>"10", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"11", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"4"}
  • {"unique-ip"=>"7", "full-text"=>"8", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"7"}
  • {"unique-ip"=>"13", "full-text"=>"8", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"8"}
  • {"unique-ip"=>"13", "full-text"=>"7", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2014", "month"=>"9"}
  • {"unique-ip"=>"22", "full-text"=>"17", "pdf"=>"11", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2014", "month"=>"10"}
  • {"unique-ip"=>"15", "full-text"=>"12", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"7", "cited-by"=>"0", "year"=>"2014", "month"=>"11"}
  • {"unique-ip"=>"9", "full-text"=>"7", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"12"}
  • {"unique-ip"=>"8", "full-text"=>"7", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"1"}
  • {"unique-ip"=>"20", "full-text"=>"23", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"2"}
  • {"unique-ip"=>"10", "full-text"=>"40", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2015", "month"=>"3"}
  • {"unique-ip"=>"16", "full-text"=>"18", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"4"}
  • {"unique-ip"=>"14", "full-text"=>"16", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"5"}
  • {"unique-ip"=>"12", "full-text"=>"11", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"6"}
  • {"unique-ip"=>"15", "full-text"=>"14", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2015", "month"=>"7"}
  • {"unique-ip"=>"25", "full-text"=>"21", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"8"}
  • {"unique-ip"=>"30", "full-text"=>"33", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"9"}
  • {"unique-ip"=>"20", "full-text"=>"18", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2015", "month"=>"10"}
  • {"unique-ip"=>"27", "full-text"=>"23", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2015", "month"=>"11"}
  • {"unique-ip"=>"39", "full-text"=>"40", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"12"}
  • {"unique-ip"=>"21", "full-text"=>"26", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"1"}
  • {"unique-ip"=>"16", "full-text"=>"14", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"2"}
  • {"unique-ip"=>"19", "full-text"=>"24", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"3"}
  • {"unique-ip"=>"40", "full-text"=>"68", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2016", "month"=>"4"}
  • {"unique-ip"=>"15", "full-text"=>"19", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"1", "year"=>"2016", "month"=>"5"}
  • {"unique-ip"=>"21", "full-text"=>"22", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"6"}
  • {"unique-ip"=>"24", "full-text"=>"27", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"4", "cited-by"=>"1", "year"=>"2016", "month"=>"7"}
  • {"unique-ip"=>"10", "full-text"=>"9", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"8"}
  • {"unique-ip"=>"43", "full-text"=>"48", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"9"}
  • {"unique-ip"=>"33", "full-text"=>"39", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"10"}
  • {"unique-ip"=>"23", "full-text"=>"22", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"11"}
  • {"unique-ip"=>"24", "full-text"=>"25", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"12"}
  • {"unique-ip"=>"19", "full-text"=>"14", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"1"}
  • {"unique-ip"=>"30", "full-text"=>"31", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"2"}
  • {"unique-ip"=>"38", "full-text"=>"40", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"12", "cited-by"=>"0", "year"=>"2017", "month"=>"3"}
  • {"unique-ip"=>"27", "full-text"=>"40", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2017", "month"=>"4"}
  • {"unique-ip"=>"21", "full-text"=>"29", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2017", "month"=>"5"}
  • {"unique-ip"=>"18", "full-text"=>"22", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"6"}
  • {"unique-ip"=>"11", "full-text"=>"13", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"7"}
  • {"unique-ip"=>"26", "full-text"=>"26", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2017", "month"=>"8"}
  • {"unique-ip"=>"61", "full-text"=>"69", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"4", "cited-by"=>"0", "year"=>"2017", "month"=>"9"}
  • {"unique-ip"=>"48", "full-text"=>"51", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"15", "cited-by"=>"0", "year"=>"2017", "month"=>"10"}
  • {"unique-ip"=>"78", "full-text"=>"98", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"11"}
  • {"unique-ip"=>"66", "full-text"=>"76", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"12"}
  • {"unique-ip"=>"67", "full-text"=>"86", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"1"}
  • {"unique-ip"=>"1", "full-text"=>"1", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"2"}
  • {"unique-ip"=>"48", "full-text"=>"53", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"11", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"3"}
  • {"unique-ip"=>"27", "full-text"=>"28", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2019", "month"=>"1"}
  • {"unique-ip"=>"46", "full-text"=>"47", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"2", "year"=>"2018", "month"=>"4"}
  • {"unique-ip"=>"39", "full-text"=>"41", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"6"}
  • {"unique-ip"=>"35", "full-text"=>"38", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"5"}
  • {"unique-ip"=>"32", "full-text"=>"37", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2018", "month"=>"7"}
  • {"unique-ip"=>"56", "full-text"=>"54", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2018", "month"=>"8"}
  • {"unique-ip"=>"79", "full-text"=>"68", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"29", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"9"}
  • {"unique-ip"=>"86", "full-text"=>"68", "pdf"=>"10", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"23", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"10"}
  • {"unique-ip"=>"58", "full-text"=>"37", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"20", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2018", "month"=>"11"}
  • {"unique-ip"=>"48", "full-text"=>"44", "pdf"=>"6", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"10", "supp-data"=>"4", "cited-by"=>"0", "year"=>"2018", "month"=>"12"}
  • {"unique-ip"=>"22", "full-text"=>"16", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"2"}
  • {"unique-ip"=>"20", "full-text"=>"18", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"3"}
  • {"unique-ip"=>"19", "full-text"=>"20", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"31", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"4"}
  • {"unique-ip"=>"21", "full-text"=>"18", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"5"}
  • {"unique-ip"=>"33", "full-text"=>"23", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"9", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"8"}
  • {"unique-ip"=>"33", "full-text"=>"31", "pdf"=>"6", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2019", "month"=>"9"}
  • {"unique-ip"=>"31", "full-text"=>"35", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"10"}
  • {"unique-ip"=>"39", "full-text"=>"41", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"12"}
  • {"unique-ip"=>"45", "full-text"=>"46", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"2", "year"=>"2020", "month"=>"2"}
  • {"unique-ip"=>"33", "full-text"=>"33", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"3"}
  • {"unique-ip"=>"82", "full-text"=>"95", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2020", "month"=>"4"}
  • {"unique-ip"=>"49", "full-text"=>"51", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"4", "cited-by"=>"0", "year"=>"2020", "month"=>"5"}
  • {"unique-ip"=>"38", "full-text"=>"41", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"6"}
  • {"unique-ip"=>"28", "full-text"=>"27", "pdf"=>"6", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"7"}
  • {"unique-ip"=>"20", "full-text"=>"19", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"8"}

Relative Metric

{"start_date"=>"2013-01-01T00:00:00Z", "end_date"=>"2013-12-31T00:00:00Z", "subject_areas"=>[{"subject_area"=>"/Biology and life sciences", "average_usage"=>[269, 466, 588, 697, 800, 896, 988, 1076, 1165, 1254, 1340, 1417]}, {"subject_area"=>"/Biology and life sciences/Evolutionary biology", "average_usage"=>[302, 488, 607, 717, 832, 931, 1024, 1117, 1212, 1302, 1389, 1469, 1535]}]}
Loading … Spinner
There are currently no alerts