A Motor-Gradient and Clustering Model of the Centripetal Motility of MTOCs in Meiosis I of Mouse Oocytes
Publication Date
October 05, 2016
Journal
PLOS Computational Biology
Authors
Neha Khetan & Chaitanya A. Athale
Volume
12
Issue
10
Pages
e1005102
DOI
https://dx.plos.org/10.1371/journal.pcbi.1005102
Publisher URL
http://journals.plos.org/ploscompbiol/article?id=10.1371%2Fjournal.pcbi.1005102
Scopus
84993250147
Mendeley
http://www.mendeley.com/research/motorgradient-clustering-model-centripetal-motility-mtocs-meiosis-i-mouse-oocytes
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Mendeley | Further Information

{"title"=>"A Motor-Gradient and Clustering Model of the Centripetal Motility of MTOCs in Meiosis I of Mouse Oocytes", "type"=>"journal", "authors"=>[{"first_name"=>"Neha", "last_name"=>"Khetan", "scopus_author_id"=>"57188583540"}, {"first_name"=>"Chaitanya A.", "last_name"=>"Athale", "scopus_author_id"=>"6507904188"}], "year"=>2016, "source"=>"PLoS Computational Biology", "identifiers"=>{"scopus"=>"2-s2.0-84994071563", "sgr"=>"84994071563", "issn"=>"15537358", "doi"=>"10.1371/journal.pcbi.1005102", "pmid"=>"27706163", "pui"=>"613093717"}, "id"=>"d1cd3668-309c-3522-a92c-84bbf7a6839f", "abstract"=>"Asters nucleated by Microtubule (MT) organizing centers (MTOCs) converge on chromosomes during spindle assembly in mouse oocytes undergoing meiosis I. Time-lapse imaging suggests that this centripetal motion is driven by a biased 'search-and-capture' mechanism. Here, we develop a model of a random walk in a drift field to test the nature of the bias and the spatio-temporal dynamics of the search process. The model is used to optimize the spatial field of drift in simulations, by comparison to experimental motility statistics. In a second step, this optimized gradient is used to determine the location of immobilized dynein motors and MT polymerization parameters, since these are hypothesized to generate the gradient of forces needed to move MTOCs. We compare these scenarios to self-organized mechanisms by which asters have been hypothesized to find the cell-center- MT pushing at the cell-boundary and clustering motor complexes. By minimizing the error between simulation outputs and experiments, we find a model of \"pulling\" by a gradient of dynein motors alone can drive the centripetal motility. Interestingly, models of passive MT based \"pushing\" at the cortex, clustering by cross-linking motors and MT-dynamic instability gradients alone, by themselves do not result in the observed motility. The model predicts the sensitivity of the results to motor density and stall force, but not MTs per aster. A hybrid model combining a chromatin-centered immobilized dynein gradient, diffusible minus-end directed clustering motors and pushing at the cell cortex, is required to comprehensively explain the available data. The model makes experimentally testable predictions of a spatial bias and self-organized mechanisms by which MT asters can find the center of a large cell.", "link"=>"http://www.mendeley.com/research/motorgradient-clustering-model-centripetal-motility-mtocs-meiosis-i-mouse-oocytes", "reader_count"=>12, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Professor > Associate Professor"=>2, "Student > Doctoral Student"=>1, "Researcher"=>2, "Student > Ph. D. Student"=>1, "Student > Master"=>2, "Student > Bachelor"=>3}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Professor > Associate Professor"=>2, "Student > Doctoral Student"=>1, "Researcher"=>2, "Student > Ph. D. Student"=>1, "Student > Master"=>2, "Student > Bachelor"=>3}, "reader_count_by_subject_area"=>{"Unspecified"=>1, "Biochemistry, Genetics and Molecular Biology"=>3, "Agricultural and Biological Sciences"=>6, "Physics and Astronomy"=>2}, "reader_count_by_subdiscipline"=>{"Physics and Astronomy"=>{"Physics and Astronomy"=>2}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>6}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>3}, "Unspecified"=>{"Unspecified"=>1}}, "reader_count_by_country"=>{"India"=>1}, "group_count"=>0}

Scopus | Further Information

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