Template-Based Modeling of Protein-RNA Interactions
Publication Date
September 23, 2016
Journal
PLOS Computational Biology
Authors
Jinfang Zheng, Petras J. Kundrotas, Ilya A. Vakser & Shiyong Liu
Volume
12
Issue
9
Pages
e1005120
DOI
https://dx.plos.org/10.1371/journal.pcbi.1005120
Publisher URL
http://journals.plos.org/ploscompbiol/article?id=10.1371%2Fjournal.pcbi.1005120
Scopus
84989284835
Mendeley
http://www.mendeley.com/research/templatebased-modeling-proteinrna-interactions
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Mendeley | Further Information

{"title"=>"Template-Based Modeling of Protein-RNA Interactions", "type"=>"journal", "authors"=>[{"first_name"=>"Jinfang", "last_name"=>"Zheng", "scopus_author_id"=>"57191379241"}, {"first_name"=>"Petras J.", "last_name"=>"Kundrotas", "scopus_author_id"=>"6701624993"}, {"first_name"=>"Ilya A.", "last_name"=>"Vakser", "scopus_author_id"=>"7003854995"}, {"first_name"=>"Shiyong", "last_name"=>"Liu", "scopus_author_id"=>"57191659009"}], "year"=>2016, "source"=>"PLoS Computational Biology", "identifiers"=>{"pmid"=>"27662342", "sgr"=>"84989284835", "doi"=>"10.1371/journal.pcbi.1005120", "scopus"=>"2-s2.0-84989284835", "pui"=>"612502397", "issn"=>"15537358"}, "id"=>"39c73aaa-b23c-39c9-ba90-21dd752b7df4", "abstract"=>"Author Summary Structures of protein-RNA complexes are important for characterization of biological processes. The number of experimentally determined protein-RNA complexes is limited. Thus modeling of these complexes is important. Reliable structural predictions of proteins and their complexes are provided by comparative modeling, which takes advantage of similar complexes with experimentally determined structures. Thus, in the case of protein-RNA complexes, it is important to determine if similar proteins and RNAs bind in a similar way. We show that, similarly to the earlier published results on protein-protein complexes, such correlation of the protein-RNA binding mode and the monomers similarity indeed exists, and is stronger when the similarity is determined by structure rather than sequence alignment. The data shows clear transition from random to similar binding mode with the increase of the structural similarity of the monomers. On the basis of the results we designed and implemented a predictive tool, which should be useful for the biological community interested in modeling of protein-RNA interactions.", "link"=>"http://www.mendeley.com/research/templatebased-modeling-proteinrna-interactions", "reader_count"=>19, "reader_count_by_academic_status"=>{"Researcher"=>5, "Student > Ph. D. Student"=>6, "Student > Master"=>2, "Student > Bachelor"=>4, "Professor"=>2}, "reader_count_by_user_role"=>{"Researcher"=>5, "Student > Ph. D. Student"=>6, "Student > Master"=>2, "Student > Bachelor"=>4, "Professor"=>2}, "reader_count_by_subject_area"=>{"Engineering"=>1, "Biochemistry, Genetics and Molecular Biology"=>9, "Agricultural and Biological Sciences"=>6, "Physics and Astronomy"=>2, "Chemistry"=>1}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>1}, "Chemistry"=>{"Chemistry"=>1}, "Physics and Astronomy"=>{"Physics and Astronomy"=>2}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>6}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>9}}, "reader_count_by_country"=>{"Poland"=>1, "Italy"=>1}, "group_count"=>0}

Scopus | Further Information

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