Mendeley | Further Information

{"title"=>"Inferential Structure Determination of Chromosomes from Single-Cell Hi-C Data", "type"=>"journal", "authors"=>[{"first_name"=>"Simeon", "last_name"=>"Carstens", "scopus_author_id"=>"55489103700"}, {"first_name"=>"Michael", "last_name"=>"Nilges", "scopus_author_id"=>"7006940093"}, {"first_name"=>"Michael", "last_name"=>"Habeck", "scopus_author_id"=>"7005882876"}], "year"=>2016, "source"=>"PLoS Computational Biology", "identifiers"=>{"sgr"=>"85007553283", "doi"=>"10.1371/journal.pcbi.1005292", "isbn"=>"1111111111", "pmid"=>"28027298", "issn"=>"15537358", "scopus"=>"2-s2.0-85007553283", "pui"=>"613954242"}, "id"=>"c355c570-8692-33a0-b407-b2c05b6b6ff9", "abstract"=>"Author Summary Spatial interactions between distant genomic regions are of fundamental importance in gene regulation and other nuclear processes. Recent chromatin crosslinking (“Hi-C”) experiments probe the spatial organization of chromosomes on a genome-wide scale to an extent that was previously unattainable. These experiments report on contacting loci and thus provide information about the three-dimensional structure of the genome. Unfortunately, the data are noisy and do not determine the structure uniquely. There is also little quantitative prior knowledge about the large-scale organization of chromosomes. Here, we address these challenges by developing a Bayesian statistical approach that combines a minimalist polymer model with chromosome size measurements and conformation capture data. Our method generates statistical ensembles of chromosome structures from extremely sparse single-cell Hi-C data. We remove potential bias by learning modeling parameters from the experimental data and apply model comparison techniques to investigate which among a set of alternative models is most supported by the Hi-C data. Our method also allows for modeling with ambiguous contact data obtained on polyploid chromosomes, which is an important step towards three-dimensional modeling of whole genomes.", "link"=>"http://www.mendeley.com/research/inferential-structure-determination-chromosomes-singlecell-hic-data-1", "reader_count"=>36, "reader_count_by_academic_status"=>{"Student > Doctoral Student"=>1, "Researcher"=>11, "Student > Ph. D. Student"=>9, "Other"=>5, "Student > Master"=>7, "Professor"=>3}, "reader_count_by_user_role"=>{"Student > Doctoral Student"=>1, "Researcher"=>11, "Student > Ph. D. Student"=>9, "Other"=>5, "Student > Master"=>7, "Professor"=>3}, "reader_count_by_subject_area"=>{"Biochemistry, Genetics and Molecular Biology"=>16, "Agricultural and Biological Sciences"=>15, "Physics and Astronomy"=>2, "Computer Science"=>3}, "reader_count_by_subdiscipline"=>{"Physics and Astronomy"=>{"Physics and Astronomy"=>2}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>15}, "Computer Science"=>{"Computer Science"=>3}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>16}}, "reader_count_by_country"=>{"Belgium"=>1, "United States"=>1, "China"=>1, "Italy"=>1, "France"=>1}, "group_count"=>0}

CrossRef

• http://doi.org/10.1126/science.aat5641
• http://doi.org/10.1186/s12575-019-0094-0
• http://doi.org/10.1093/nar/gky065
• http://doi.org/10.1021/acs.jpclett.8b02439
• http://doi.org/10.1038/s41598-019-41369-w
• http://doi.org/10.1016/j.sbi.2017.07.001
• http://doi.org/10.1093/bioinformatics/btz181
• http://doi.org/10.1038/s41467-019-10005-6
• http://doi.org/10.1002/wsbm.1435
• http://doi.org/10.1016/j.cell.2019.01.020
• http://doi.org/10.1016/j.ymeth.2019.08.008
• http://doi.org/10.3389/fmolb.2017.00015

Scopus | Further Information

{"@_fa"=>"true", "link"=>[{"@_fa"=>"true", "@ref"=>"self", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/85007553283"}, {"@_fa"=>"true", "@ref"=>"author-affiliation", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/85007553283?field=author,affiliation"}, {"@_fa"=>"true", "@ref"=>"scopus", "@href"=>"https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85007553283&origin=inward"}, {"@_fa"=>"true", "@ref"=>"scopus-citedby", "@href"=>"https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=85007553283&origin=inward"}], "prism:url"=>"https://api.elsevier.com/content/abstract/scopus_id/85007553283", "dc:identifier"=>"SCOPUS_ID:85007553283", "eid"=>"2-s2.0-85007553283", "dc:title"=>"Inferential Structure Determination of Chromosomes from Single-Cell Hi-C Data", "dc:creator"=>"Carstens S.", "prism:publicationName"=>"PLoS Computational Biology", "prism:issn"=>"1553734X", "prism:eIssn"=>"15537358", "prism:volume"=>"12", "prism:issueIdentifier"=>"12", "prism:pageRange"=>nil, "prism:coverDate"=>"2016-12-01", "prism:coverDisplayDate"=>"December 2016", "prism:doi"=>"10.1371/journal.pcbi.1005292", "citedby-count"=>"13", "affiliation"=>[{"@_fa"=>"true", "affilname"=>"New York University", "affiliation-city"=>"New York", "affiliation-country"=>"United States"}, {"@_fa"=>"true", "affilname"=>"Institut Pasteur, Paris", "affiliation-city"=>"Paris", "affiliation-country"=>"France"}], "pubmed-id"=>"28027298", "prism:aggregationType"=>"Journal", "subtype"=>"ar", "subtypeDescription"=>"Article", "article-number"=>"e1005292", "source-id"=>"4000151810", "openaccess"=>"1", "openaccessFlag"=>true}

Web of Science®

Article Coverage Curated

• {"referral"=>"http://blogs.plos.org/mindthebrain/wp-content/plugins/orcid-master/assets/orcid.png", "language"=>"", "title"=>"", "type"=>"Discussion board", "publication"=>"blogs.plos.org", "published_on"=>"", "link_state"=>"APPROVED"}
• {"referral"=>"http://blogs.plos.org/scied/?p=3666", "language"=>"English", "title"=>"To Boldly Go Where No Scientist Has Gone Before | Sci-Ed", "type"=>"Blog", "publication"=>"Sci-Ed", "published_on"=>"", "link_state"=>"APPROVED"}
• {"referral"=>"http://blogs.plos.org/thestudentblog/category/academia/", "language"=>"English", "title"=>"Academia | PLOS ECR Community", "type"=>"Blog", "publication"=>"blogs.plos.org", "published_on"=>"", "link_state"=>"APPROVED"}

Twitter

• {"id"=>"814176926017339392", "text"=>"Inferential Structure Determination of Chromosomes from Single-Cell Hi-C Data https://t.co/pLjKEkYlaB", "created_at"=>"2016-12-28T18:31:20Z", "user"=>"CayleyAerospace", "user_name"=>"Chartered Engineer", "user_profile_image"=>"http://pbs.twimg.com/profile_images/527561411946229760/XDhwvvH5_normal.jpeg"}
• {"id"=>"815858903430889472", "text"=>"Inferential Structure Determination of Chromosomes from Single-Cell Hi-C Data @PLOSCompBiol https://t.co/4rXtR4Bq4K", "created_at"=>"2017-01-02T09:54:55Z", "user"=>"3D_Genome", "user_name"=>"Genome in 3-D", "user_profile_image"=>"http://pbs.twimg.com/profile_images/438305179612360705/OgwNE0hU_normal.jpeg"}
• {"id"=>"815869376268103680", "text"=>"RT @3D_Genome: Inferential Structure Determination of Chromosomes from Single-Cell Hi-C Data @PLOSCompBiol https://t.co/4rXtR4Bq4K", "created_at"=>"2017-01-02T10:36:32Z", "user"=>"ktzaleta", "user_name"=>"Kathia Zaleta", "user_profile_image"=>"http://pbs.twimg.com/profile_images/811443898488799232/zr_M-I49_normal.jpg"}
• {"id"=>"815888488633614336", "text"=>"RT @3D_Genome: Inferential Structure Determination of Chromosomes from Single-Cell Hi-C Data @PLOSCompBiol https://t.co/4rXtR4Bq4K", "created_at"=>"2017-01-02T11:52:28Z", "user"=>"yad_ghavi", "user_name"=>"Yad Ghavi-Helm", "user_profile_image"=>"http://pbs.twimg.com/profile_images/707271217309421568/kE1Y6u_I_normal.jpg"}
• {"id"=>"815917460981481472", "text"=>"RT @3D_Genome: Inferential Structure Determination of Chromosomes from Single-Cell Hi-C Data @PLOSCompBiol https://t.co/4rXtR4Bq4K", "created_at"=>"2017-01-02T13:47:36Z", "user"=>"gauravjain49", "user_name"=>"Gaurav Jain", "user_profile_image"=>"http://pbs.twimg.com/profile_images/378800000228610142/d5ded083836c479aa4b0337bfd58bbd4_normal.png"}
• {"id"=>"815922513385582592", "text"=>"RT @3D_Genome: Inferential Structure Determination of Chromosomes from Single-Cell Hi-C Data @PLOSCompBiol https://t.co/4rXtR4Bq4K", "created_at"=>"2017-01-02T14:07:40Z", "user"=>"vivekbhr", "user_name"=>"Vivek Bhardwaj", "user_profile_image"=>"http://pbs.twimg.com/profile_images/602896029151862785/cqrQas0J_normal.png"}
• {"id"=>"815922985186033665", "text"=>"RT @3D_Genome: Inferential Structure Determination of Chromosomes from Single-Cell Hi-C Data @PLOSCompBiol https://t.co/4rXtR4Bq4K", "created_at"=>"2017-01-02T14:09:33Z", "user"=>"FirasSadiyah", "user_name"=>"Firas Sadiyah", "user_profile_image"=>"http://pbs.twimg.com/profile_images/677588145601421312/7b-sro-p_normal.png"}
• {"id"=>"815931018955935744", "text"=>"RT @3D_Genome: Inferential Structure Determination of Chromosomes from Single-Cell Hi-C Data @PLOSCompBiol https://t.co/4rXtR4Bq4K", "created_at"=>"2017-01-02T14:41:28Z", "user"=>"SurgeonRetina", "user_name"=>"Rajesh Rao, MD", "user_profile_image"=>"http://pbs.twimg.com/profile_images/634748087462948865/2_74aT9z_normal.jpg"}
• {"id"=>"816569503043780608", "text"=>"RT @3D_Genome: Inferential Structure Determination of Chromosomes from Single-Cell Hi-C Data @PLOSCompBiol https://t.co/4rXtR4Bq4K", "created_at"=>"2017-01-04T08:58:35Z", "user"=>"LeopoldCarron", "user_name"=>"Carron L?opold", "user_profile_image"=>"http://pbs.twimg.com/profile_images/698269756588212224/EwpU363K_normal.jpg"}
• {"id"=>"816827061792686083", "text"=>"RT @3D_Genome: Inferential Structure Determination of Chromosomes from Single-Cell Hi-C Data @PLOSCompBiol https://t.co/4rXtR4Bq4K", "created_at"=>"2017-01-05T02:02:02Z", "user"=>"JChrisPires", "user_name"=>"J. Chris Pires", "user_profile_image"=>"http://pbs.twimg.com/profile_images/1416048607/jcp_2011_normal.jpg"}
• {"id"=>"816830078940315648", "text"=>"RT @3D_Genome: Inferential Structure Determination of Chromosomes from Single-Cell Hi-C Data @PLOSCompBiol https://t.co/4rXtR4Bq4K", "created_at"=>"2017-01-05T02:14:01Z", "user"=>"BiswapriyaMisra", "user_name"=>"Biswapriya Misra", "user_profile_image"=>"http://pbs.twimg.com/profile_images/800544755608391681/KdbIsjK9_normal.jpg"}
• {"id"=>"817057168549642240", "text"=>"RT @3D_Genome: Inferential Structure Determination of Chromosomes from Single-Cell Hi-C Data @PLOSCompBiol https://t.co/4rXtR4Bq4K", "created_at"=>"2017-01-05T17:16:23Z", "user"=>"svenas71", "user_name"=>"Sven Sewitz", "user_profile_image"=>"http://pbs.twimg.com/profile_images/505303288313417728/IoAXWhca_normal.jpeg"}
• {"id"=>"817160567039238144", "text"=>"RT @3D_Genome: Inferential Structure Determination of Chromosomes from Single-Cell Hi-C Data @PLOSCompBiol https://t.co/4rXtR4Bq4K", "created_at"=>"2017-01-06T00:07:15Z", "user"=>"IHEC_Epigenomes", "user_name"=>"IHEC_Epigenomes", "user_profile_image"=>"http://pbs.twimg.com/profile_images/591220377512189952/ANrpYvKO_normal.png"}

Wikipedia

Counter

• {"month"=>"12", "year"=>"2016", "pdf_views"=>"75", "xml_views"=>"4", "html_views"=>"379"}
• {"month"=>"1", "year"=>"2017", "pdf_views"=>"152", "xml_views"=>"5", "html_views"=>"1299"}
• {"month"=>"2", "year"=>"2017", "pdf_views"=>"39", "xml_views"=>"0", "html_views"=>"172"}
• {"month"=>"3", "year"=>"2017", "pdf_views"=>"29", "xml_views"=>"1", "html_views"=>"173"}
• {"month"=>"4", "year"=>"2017", "pdf_views"=>"21", "xml_views"=>"0", "html_views"=>"93"}
• {"month"=>"5", "year"=>"2017", "pdf_views"=>"20", "xml_views"=>"1", "html_views"=>"114"}
• {"month"=>"6", "year"=>"2017", "pdf_views"=>"14", "xml_views"=>"0", "html_views"=>"86"}
• {"month"=>"7", "year"=>"2017", "pdf_views"=>"18", "xml_views"=>"0", "html_views"=>"65"}
• {"month"=>"8", "year"=>"2017", "pdf_views"=>"25", "xml_views"=>"1", "html_views"=>"95"}
• {"month"=>"9", "year"=>"2017", "pdf_views"=>"20", "xml_views"=>"3", "html_views"=>"76"}
• {"month"=>"10", "year"=>"2017", "pdf_views"=>"18", "xml_views"=>"0", "html_views"=>"65"}
• {"month"=>"11", "year"=>"2017", "pdf_views"=>"24", "xml_views"=>"0", "html_views"=>"65"}
• {"month"=>"12", "year"=>"2017", "pdf_views"=>"25", "xml_views"=>"2", "html_views"=>"46"}
• {"month"=>"1", "year"=>"2018", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"40"}
• {"month"=>"2", "year"=>"2018", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"17"}
• {"month"=>"3", "year"=>"2018", "pdf_views"=>"19", "xml_views"=>"2", "html_views"=>"30"}
• {"month"=>"4", "year"=>"2018", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"28"}
• {"month"=>"5", "year"=>"2018", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"35"}
• {"month"=>"6", "year"=>"2018", "pdf_views"=>"15", "xml_views"=>"0", "html_views"=>"43"}
• {"month"=>"7", "year"=>"2018", "pdf_views"=>"5", "xml_views"=>"5", "html_views"=>"12"}
• {"month"=>"8", "year"=>"2018", "pdf_views"=>"45", "xml_views"=>"1", "html_views"=>"60"}
• {"month"=>"9", "year"=>"2018", "pdf_views"=>"40", "xml_views"=>"1", "html_views"=>"46"}
• {"month"=>"10", "year"=>"2018", "pdf_views"=>"28", "xml_views"=>"2", "html_views"=>"24"}
• {"month"=>"11", "year"=>"2018", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"16"}
• {"month"=>"12", "year"=>"2018", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"17"}
• {"month"=>"1", "year"=>"2019", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"12"}
• {"month"=>"2", "year"=>"2019", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"28"}
• {"month"=>"3", "year"=>"2019", "pdf_views"=>"36", "xml_views"=>"3", "html_views"=>"42"}
• {"month"=>"4", "year"=>"2019", "pdf_views"=>"25", "xml_views"=>"0", "html_views"=>"19"}
• {"month"=>"5", "year"=>"2019", "pdf_views"=>"19", "xml_views"=>"0", "html_views"=>"29"}
• {"month"=>"6", "year"=>"2019", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"32"}
• {"month"=>"7", "year"=>"2019", "pdf_views"=>"13", "xml_views"=>"6", "html_views"=>"25"}
• {"month"=>"8", "year"=>"2019", "pdf_views"=>"19", "xml_views"=>"0", "html_views"=>"15"}
• {"month"=>"9", "year"=>"2019", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"15"}
• {"month"=>"10", "year"=>"2019", "pdf_views"=>"20", "xml_views"=>"0", "html_views"=>"24"}
• {"month"=>"11", "year"=>"2019", "pdf_views"=>"14", "xml_views"=>"0", "html_views"=>"14"}

PMC Usage Stats

• {"unique-ip"=>"4", "full-text"=>"5", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"1"}
• {"unique-ip"=>"33", "full-text"=>"40", "pdf"=>"11", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"20", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2017", "month"=>"2"}
• {"unique-ip"=>"19", "full-text"=>"20", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"3"}
• {"unique-ip"=>"11", "full-text"=>"14", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"4"}
• {"unique-ip"=>"18", "full-text"=>"20", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"5"}
• {"unique-ip"=>"5", "full-text"=>"5", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"6"}
• {"unique-ip"=>"14", "full-text"=>"15", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2017", "month"=>"7"}
• {"unique-ip"=>"13", "full-text"=>"17", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2017", "month"=>"8"}
• {"unique-ip"=>"9", "full-text"=>"9", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"9"}
• {"unique-ip"=>"8", "full-text"=>"7", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"10"}
• {"unique-ip"=>"34", "full-text"=>"11", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"11", "supp-data"=>"18", "cited-by"=>"1", "year"=>"2017", "month"=>"11"}
• {"unique-ip"=>"5", "full-text"=>"11", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2017", "month"=>"12"}
• {"unique-ip"=>"2", "full-text"=>"2", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"1"}
• {"unique-ip"=>"1", "full-text"=>"1", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"2"}
• {"unique-ip"=>"8", "full-text"=>"7", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"3"}
• {"unique-ip"=>"10", "full-text"=>"11", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"1"}
• {"unique-ip"=>"7", "full-text"=>"8", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"5"}
• {"unique-ip"=>"5", "full-text"=>"4", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"17", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2018", "month"=>"4"}
• {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"6"}
• {"unique-ip"=>"14", "full-text"=>"8", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"8", "cited-by"=>"0", "year"=>"2018", "month"=>"7"}
• {"unique-ip"=>"14", "full-text"=>"17", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"8"}
• {"unique-ip"=>"10", "full-text"=>"12", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"9"}
• {"unique-ip"=>"8", "full-text"=>"8", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"10"}
• {"unique-ip"=>"4", "full-text"=>"5", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"17", "cited-by"=>"0", "year"=>"2018", "month"=>"11"}
• {"unique-ip"=>"9", "full-text"=>"11", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"12"}
• {"unique-ip"=>"15", "full-text"=>"8", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"21", "year"=>"2019", "month"=>"2"}
• {"unique-ip"=>"10", "full-text"=>"11", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2019", "month"=>"3"}
• {"unique-ip"=>"5", "full-text"=>"4", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2019", "month"=>"4"}
• {"unique-ip"=>"13", "full-text"=>"11", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"5"}
• {"unique-ip"=>"8", "full-text"=>"6", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"8"}
• {"unique-ip"=>"16", "full-text"=>"13", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"9"}
• {"unique-ip"=>"12", "full-text"=>"14", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"10"}

F1000Prime | Further Information

• {"year"=>2017, "month"=>2, "doi"=>"10.1371/journal.pcbi.1005292", "f1000_id"=>"727146656", "url"=>"http://f1000.com/prime/727146656", "score"=>2, "classifications"=>["technical_advance"], "updated_at"=>"2017-02-27T09:41:24Z"}
• {"year"=>2017, "month"=>3, "doi"=>"10.1371/journal.pcbi.1005292", "f1000_id"=>"727146656", "url"=>"http://f1000.com/prime/727146656", "score"=>2, "classifications"=>["technical_advance"], "updated_at"=>"2017-03-27T08:41:20Z"}
• {"year"=>2017, "month"=>4, "doi"=>"10.1371/journal.pcbi.1005292", "f1000_id"=>"727146656", "url"=>"http://f1000.com/prime/727146656", "score"=>2, "classifications"=>["technical_advance"], "updated_at"=>"2017-04-24T08:41:17Z"}
• {"year"=>2017, "month"=>5, "doi"=>"10.1371/journal.pcbi.1005292", "f1000_id"=>"727146656", "url"=>"http://f1000.com/prime/727146656", "score"=>2, "classifications"=>["technical_advance"], "updated_at"=>"2017-05-29T08:41:16Z"}
• {"year"=>2017, "month"=>6, "doi"=>"10.1371/journal.pcbi.1005292", "f1000_id"=>"727146656", "url"=>"http://f1000.com/prime/727146656", "score"=>2, "classifications"=>["technical_advance"], "updated_at"=>"2017-06-26T08:41:22Z"}
• {"year"=>2017, "month"=>7, "doi"=>"10.1371/journal.pcbi.1005292", "f1000_id"=>"727146656", "url"=>"https://f1000.com/prime/727146656", "score"=>2, "classifications"=>["technical_advance"], "updated_at"=>"2017-07-31T08:41:25Z"}
• {"year"=>2017, "month"=>8, "doi"=>"10.1371/journal.pcbi.1005292", "f1000_id"=>"727146656", "url"=>"https://f1000.com/prime/727146656", "score"=>2, "classifications"=>["technical_advance"], "updated_at"=>"2017-08-28T08:41:22Z"}
• {"year"=>2017, "month"=>9, "doi"=>"10.1371/journal.pcbi.1005292", "f1000_id"=>"727146656", "url"=>"https://f1000.com/prime/727146656", "score"=>2, "classifications"=>["technical_advance"], "updated_at"=>"2017-09-25T08:41:28Z"}
• {"year"=>2017, "month"=>10, "doi"=>"10.1371/journal.pcbi.1005292", "f1000_id"=>"727146656", "url"=>"https://f1000.com/prime/727146656", "score"=>2, "classifications"=>["technical_advance"], "updated_at"=>"2017-10-30T08:41:47Z"}
• {"year"=>2017, "month"=>11, "doi"=>"10.1371/journal.pcbi.1005292", "f1000_id"=>"727146656", "url"=>"https://f1000.com/prime/727146656", "score"=>2, "classifications"=>["technical_advance"], "updated_at"=>"2017-11-27T09:41:29Z"}
• {"year"=>2017, "month"=>12, "doi"=>"10.1371/journal.pcbi.1005292", "f1000_id"=>"727146656", "url"=>"https://f1000.com/prime/727146656", "score"=>2, "classifications"=>["technical_advance"], "updated_at"=>"2017-12-25T09:41:22Z"}
• {"year"=>2018, "month"=>1, "doi"=>"10.1371/journal.pcbi.1005292", "f1000_id"=>"727146656", "url"=>"https://f1000.com/prime/727146656", "score"=>2, "classifications"=>["technical_advance"], "updated_at"=>"2018-01-29T09:41:07Z"}
• {"year"=>2018, "month"=>2, "doi"=>"10.1371/journal.pcbi.1005292", "f1000_id"=>"727146656", "url"=>"https://f1000.com/prime/727146656", "score"=>2, "classifications"=>["technical_advance"], "updated_at"=>"2018-02-26T09:41:07Z"}
• {"year"=>2018, "month"=>3, "doi"=>"10.1371/journal.pcbi.1005292", "f1000_id"=>"727146656", "url"=>"https://f1000.com/prime/727146656", "score"=>2, "classifications"=>["technical_advance"], "updated_at"=>"2018-03-26T08:41:11Z"}
• {"year"=>2018, "month"=>4, "doi"=>"10.1371/journal.pcbi.1005292", "f1000_id"=>"727146656", "url"=>"https://f1000.com/prime/727146656", "score"=>2, "classifications"=>["technical_advance"], "updated_at"=>"2018-04-30T08:41:06Z"}
• {"year"=>2018, "month"=>5, "doi"=>"10.1371/journal.pcbi.1005292", "f1000_id"=>"727146656", "url"=>"https://f1000.com/prime/727146656", "score"=>2, "classifications"=>["technical_advance"], "updated_at"=>"2018-05-28T08:41:08Z"}
• {"year"=>2018, "month"=>6, "doi"=>"10.1371/journal.pcbi.1005292", "f1000_id"=>"727146656", "url"=>"https://f1000.com/prime/727146656", "score"=>2, "classifications"=>["technical_advance"], "updated_at"=>"2018-06-25T08:41:09Z"}
• {"year"=>2018, "month"=>7, "doi"=>"10.1371/journal.pcbi.1005292", "f1000_id"=>"727146656", "url"=>"https://f1000.com/prime/727146656", "score"=>2, "classifications"=>["technical_advance"], "updated_at"=>"2018-07-30T08:41:18Z"}
• {"year"=>2018, "month"=>8, "doi"=>"10.1371/journal.pcbi.1005292", "f1000_id"=>"727146656", "url"=>"https://f1000.com/prime/727146656", "score"=>2, "classifications"=>["technical_advance"], "updated_at"=>"2018-08-27T08:41:33Z"}
• {"year"=>2018, "month"=>9, "doi"=>"10.1371/journal.pcbi.1005292", "f1000_id"=>"727146656", "url"=>"https://f1000.com/prime/727146656", "score"=>2, "classifications"=>["technical_advance"], "updated_at"=>"2018-09-24T08:41:21Z"}
• {"year"=>2018, "month"=>10, "doi"=>"10.1371/journal.pcbi.1005292", "f1000_id"=>"727146656", "url"=>"https://f1000.com/prime/727146656", "score"=>2, "classifications"=>["technical_advance"], "updated_at"=>"2018-10-29T08:41:27Z"}
• {"year"=>2018, "month"=>11, "doi"=>"10.1371/journal.pcbi.1005292", "f1000_id"=>"727146656", "url"=>"https://f1000.com/prime/727146656", "score"=>2, "classifications"=>["technical_advance"], "updated_at"=>"2018-11-26T09:41:25Z"}
• {"year"=>2018, "month"=>12, "doi"=>"10.1371/journal.pcbi.1005292", "f1000_id"=>"727146656", "url"=>"https://f1000.com/prime/727146656", "score"=>2, "classifications"=>["technical_advance"], "updated_at"=>"2018-12-31T09:41:37Z"}
• {"year"=>2019, "month"=>1, "doi"=>"10.1371/journal.pcbi.1005292", "f1000_id"=>"727146656", "url"=>"https://f1000.com/prime/727146656", "score"=>2, "classifications"=>["technical_advance"], "updated_at"=>"2019-01-28T09:41:25Z"}
• {"year"=>2019, "month"=>2, "doi"=>"10.1371/journal.pcbi.1005292", "f1000_id"=>"727146656", "url"=>"https://f1000.com/prime/727146656", "score"=>2, "classifications"=>["technical_advance"], "updated_at"=>"2019-02-25T09:41:18Z"}
• {"year"=>2019, "month"=>3, "doi"=>"10.1371/journal.pcbi.1005292", "f1000_id"=>"727146656", "url"=>"https://f1000.com/prime/727146656", "score"=>2, "classifications"=>["technical_advance"], "updated_at"=>"2019-03-25T08:41:13Z"}
• {"year"=>2019, "month"=>4, "doi"=>"10.1371/journal.pcbi.1005292", "f1000_id"=>"727146656", "url"=>"https://f1000.com/prime/727146656", "score"=>2, "classifications"=>["technical_advance"], "updated_at"=>"2019-04-29T08:41:22Z"}
• {"year"=>2019, "month"=>5, "doi"=>"10.1371/journal.pcbi.1005292", "f1000_id"=>"727146656", "url"=>"https://f1000.com/prime/727146656", "score"=>2, "classifications"=>["technical_advance"], "updated_at"=>"2019-05-27T08:41:35Z"}
• {"year"=>2019, "month"=>6, "doi"=>"10.1371/journal.pcbi.1005292", "f1000_id"=>"727146656", "url"=>"https://f1000.com/prime/727146656", "score"=>2, "classifications"=>["technical_advance"], "updated_at"=>"2019-06-24T08:41:22Z"}
• {"year"=>2019, "month"=>7, "doi"=>"10.1371/journal.pcbi.1005292", "f1000_id"=>"727146656", "url"=>"https://f1000.com/prime/727146656", "score"=>2, "classifications"=>["technical_advance"], "updated_at"=>"2019-07-29T08:41:48Z"}
• {"year"=>2019, "month"=>8, "doi"=>"10.1371/journal.pcbi.1005292", "f1000_id"=>"727146656", "url"=>"https://f1000.com/prime/727146656", "score"=>2, "classifications"=>["technical_advance"], "updated_at"=>"2019-08-26T08:41:32Z"}
• {"year"=>2019, "month"=>9, "doi"=>"10.1371/journal.pcbi.1005292", "f1000_id"=>"727146656", "url"=>"https://f1000.com/prime/727146656", "score"=>2, "classifications"=>["technical_advance"], "updated_at"=>"2019-09-30T08:41:29Z"}
• {"year"=>2019, "month"=>10, "doi"=>"10.1371/journal.pcbi.1005292", "f1000_id"=>"727146656", "url"=>"https://f1000.com/prime/727146656", "score"=>2, "classifications"=>["technical_advance"], "updated_at"=>"2019-10-28T08:41:32Z"}
• {"year"=>2019, "month"=>11, "doi"=>"10.1371/journal.pcbi.1005292", "f1000_id"=>"727146656", "url"=>"https://f1000.com/prime/727146656", "score"=>2, "classifications"=>["technical_advance"], "updated_at"=>"2019-11-11T09:41:29Z"}