Persisting fetal clonotypes influence the structure and overlap of adult human T cell receptor repertoires
Publication Date
July 06, 2017
Authors
Mikhail V. Pogorelyy, Yuval Elhanati, Quentin Marcou, Anastasiia L. Sycheva, et al
Volume
13
Issue
7
Pages
e1005572
DOI
https://dx.plos.org/10.1371/journal.pcbi.1005572
Publisher URL
http://journals.plos.org/ploscompbiol/article?id=10.1371%2Fjournal.pcbi.1005572
Scopus
85026627636
Mendeley
http://www.mendeley.com/research/persisting-fetal-clonotypes-influence-structure-overlap-adult-human-t-cell-receptor-repertoires
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Mendeley | Further Information

{"title"=>"Persisting fetal clonotypes influence the structure and overlap of adult human T cell receptor repertoires", "type"=>"journal", "authors"=>[{"first_name"=>"Mikhail V.", "last_name"=>"Pogorelyy", "scopus_author_id"=>"55805510300"}, {"first_name"=>"Yuval", "last_name"=>"Elhanati", "scopus_author_id"=>"37103828200"}, {"first_name"=>"Quentin", "last_name"=>"Marcou", "scopus_author_id"=>"56732983000"}, {"first_name"=>"Anastasiia L.", "last_name"=>"Sycheva", "scopus_author_id"=>"57192230816"}, {"first_name"=>"Ekaterina A.", "last_name"=>"Komech", "scopus_author_id"=>"56126209100"}, {"first_name"=>"Vadim I.", "last_name"=>"Nazarov", "scopus_author_id"=>"56524940900"}, {"first_name"=>"Olga V.", "last_name"=>"Britanova", "scopus_author_id"=>"6603480144"}, {"first_name"=>"Dmitriy M.", "last_name"=>"Chudakov", "scopus_author_id"=>"6603256160"}, {"first_name"=>"Ilgar Z.", "last_name"=>"Mamedov", "scopus_author_id"=>"7007124123"}, {"first_name"=>"Yury B.", "last_name"=>"Lebedev", "scopus_author_id"=>"35569600300"}, {"first_name"=>"Thierry", "last_name"=>"Mora", "scopus_author_id"=>"6701596511"}, {"first_name"=>"Aleksandra M.", "last_name"=>"Walczak", "scopus_author_id"=>"8580135900"}], "year"=>2017, "source"=>"PLoS Computational Biology", "identifiers"=>{"scopus"=>"2-s2.0-85026627636", "arxiv"=>"1602.03063", "sgr"=>"85026627636", "doi"=>"10.1371/journal.pcbi.1005572", "pui"=>"617638735", "pmid"=>"28683116", "isbn"=>"1111111111", "issn"=>"15537358"}, "id"=>"6bf0446a-3390-33d6-9b71-3f8b3bc65475", "abstract"=>"The diversity of T-cell receptors recognizing foreign pathogens is generated through a highly stochastic recombination process, making the independent production of the same sequence rare. Yet unrelated individuals do share receptors, which together constitute a “public” repertoire of abundant clonotypes. The TCR repertoire is initially formed prenatally, when the enzyme inserting random nucleotides is downregulated, producing a limited diversity subset. By statistically analyzing deep sequencing T-cell repertoire data from twins, unrelated individuals of various ages, and cord blood, we show that T-cell clones generated before birth persist and maintain high abundances in adult organisms for decades, slowly decaying with age. Our results suggest that large, low-diversity public clones are created during pregnancy, and survive over long periods, providing the basis of the public repertoire.", "link"=>"http://www.mendeley.com/research/persisting-fetal-clonotypes-influence-structure-overlap-adult-human-t-cell-receptor-repertoires", "reader_count"=>34, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Professor > Associate Professor"=>2, "Researcher"=>8, "Student > Ph. D. Student"=>8, "Student > Postgraduate"=>3, "Student > Master"=>6, "Other"=>2, "Student > Bachelor"=>2, "Professor"=>2}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Professor > Associate Professor"=>2, "Researcher"=>8, "Student > Ph. D. Student"=>8, "Student > Postgraduate"=>3, "Student > Master"=>6, "Other"=>2, "Student > Bachelor"=>2, "Professor"=>2}, "reader_count_by_subject_area"=>{"Unspecified"=>2, "Biochemistry, Genetics and Molecular Biology"=>4, "Agricultural and Biological Sciences"=>11, "Medicine and Dentistry"=>3, "Physics and Astronomy"=>7, "Immunology and Microbiology"=>6, "Chemistry"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>3}, "Chemistry"=>{"Chemistry"=>1}, "Physics and Astronomy"=>{"Physics and Astronomy"=>7}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>6}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>11}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>4}, "Unspecified"=>{"Unspecified"=>2}}, "reader_count_by_country"=>{"Russia"=>1}, "group_count"=>1}

Scopus | Further Information

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