Structural host-microbiota interaction networks
Publication Date
October 12, 2017
Authors
Emine Guven Maiorov, Chung Jung Tsai & Ruth Nussinov
Volume
13
Issue
10
Pages
e1005579
DOI
https://dx.plos.org/10.1371/journal.pcbi.1005579
Publisher URL
http://journals.plos.org/ploscompbiol/article?id=10.1371%2Fjournal.pcbi.1005579
Scopus
85031927007
Mendeley
http://www.mendeley.com/research/structural-hostmicrobiota-interaction-networks
Events
Loading … Spinner

Mendeley | Further Information

{"title"=>"Structural host-microbiota interaction networks", "type"=>"generic", "authors"=>[{"first_name"=>"Emine", "last_name"=>"Guven-Maiorov", "scopus_author_id"=>"55762381700"}, {"first_name"=>"Chung Jung", "last_name"=>"Tsai", "scopus_author_id"=>"7404968077"}, {"first_name"=>"Ruth", "last_name"=>"Nussinov", "scopus_author_id"=>"34572176500"}], "year"=>2017, "source"=>"PLoS Computational Biology", "identifiers"=>{"scopus"=>"2-s2.0-85031927007", "sgr"=>"85031927007", "doi"=>"10.1371/journal.pcbi.1005579", "pui"=>"619081508", "pmid"=>"29023448", "isbn"=>"1111111111", "issn"=>"15537358"}, "id"=>"3e3da590-8eba-3afd-8dc3-933002555ae6", "abstract"=>"Hundreds of different species colonize multicellular organisms making them “metaorganisms”. A growing body of data supports the role of microbiota in health and in disease. Grasping the principles of host-microbiota interactions (HMIs) at the molecular level is important since it may provide insights into the mechanisms of infections. The crosstalk between the host and the microbiota may help resolve puzzling questions such as how a microorganism can contribute to both health and disease. Integrated superorganism networks that consider host and microbiota as a whole–may uncover their code, clarifying perhaps the most fundamental question: how they modulate immune surveillance. Within this framework, structural HMI networks can uniquely identify potential microbial effectors that target distinct host nodes or interfere with endogenous host interactions, as well as how mutations on either host or microbial proteins affect the interaction. Furthermore, structural HMIs can help identify master host cell regulator nodes and modules whose tweaking by the microbes promote aberrant activity. Collectively, these data can delineate pathogenic mechanisms and thereby help maximize beneficial therapeutics. To date, challenges in experimental techniques limit large-scale characterization of HMIs. Here we highlight an area in its infancy which we believe will increasingly engage the computational community: predicting interactions across kingdoms, and mapping these on the host cellular networks to figure out how commensal and pathogenic microbiota modulate the host signaling and broadly cross-species consequences.", "link"=>"http://www.mendeley.com/research/structural-hostmicrobiota-interaction-networks", "reader_count"=>51, "reader_count_by_academic_status"=>{"Unspecified"=>5, "Professor > Associate Professor"=>2, "Student > Doctoral Student"=>2, "Researcher"=>12, "Student > Ph. D. Student"=>14, "Student > Postgraduate"=>2, "Student > Master"=>7, "Other"=>1, "Student > Bachelor"=>1, "Lecturer"=>3, "Professor"=>2}, "reader_count_by_user_role"=>{"Unspecified"=>5, "Professor > Associate Professor"=>2, "Student > Doctoral Student"=>2, "Researcher"=>12, "Student > Ph. D. Student"=>14, "Student > Postgraduate"=>2, "Student > Master"=>7, "Other"=>1, "Student > Bachelor"=>1, "Lecturer"=>3, "Professor"=>2}, "reader_count_by_subject_area"=>{"Unspecified"=>9, "Environmental Science"=>2, "Biochemistry, Genetics and Molecular Biology"=>8, "Agricultural and Biological Sciences"=>20, "Medicine and Dentistry"=>2, "Arts and Humanities"=>1, "Pharmacology, Toxicology and Pharmaceutical Science"=>1, "Psychology"=>1, "Computer Science"=>3, "Immunology and Microbiology"=>3, "Earth and Planetary Sciences"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>2}, "Psychology"=>{"Psychology"=>1}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>3}, "Earth and Planetary Sciences"=>{"Earth and Planetary Sciences"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>20}, "Computer Science"=>{"Computer Science"=>3}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>8}, "Unspecified"=>{"Unspecified"=>9}, "Environmental Science"=>{"Environmental Science"=>2}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>1}, "Arts and Humanities"=>{"Arts and Humanities"=>1}}, "group_count"=>3}

Scopus | Further Information

{"@_fa"=>"true", "link"=>[{"@_fa"=>"true", "@ref"=>"self", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/85031927007"}, {"@_fa"=>"true", "@ref"=>"author-affiliation", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/85031927007?field=author,affiliation"}, {"@_fa"=>"true", "@ref"=>"scopus", "@href"=>"https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85031927007&origin=inward"}, {"@_fa"=>"true", "@ref"=>"scopus-citedby", "@href"=>"https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=85031927007&origin=inward"}], "prism:url"=>"https://api.elsevier.com/content/abstract/scopus_id/85031927007", "dc:identifier"=>"SCOPUS_ID:85031927007", "eid"=>"2-s2.0-85031927007", "dc:title"=>"Structural host-microbiota interaction networks", "dc:creator"=>"Guven-Maiorov E.", "prism:publicationName"=>"PLoS Computational Biology", "prism:issn"=>"1553734X", "prism:eIssn"=>"15537358", "prism:volume"=>"13", "prism:issueIdentifier"=>"10", "prism:pageRange"=>nil, "prism:coverDate"=>"2017-10-01", "prism:coverDisplayDate"=>"October 2017", "prism:doi"=>"10.1371/journal.pcbi.1005579", "citedby-count"=>"10", "affiliation"=>[{"@_fa"=>"true", "affilname"=>"Leidos Inc.", "affiliation-city"=>"Reston", "affiliation-country"=>"United States"}], "pubmed-id"=>"29023448", "prism:aggregationType"=>"Journal", "subtype"=>"re", "subtypeDescription"=>"Review", "article-number"=>"e1005579", "source-id"=>"4000151810", "openaccess"=>"1", "openaccessFlag"=>true}

Twitter

Counter

  • {"month"=>"10", "year"=>"2017", "pdf_views"=>"405", "xml_views"=>"8", "html_views"=>"1828"}
  • {"month"=>"11", "year"=>"2017", "pdf_views"=>"216", "xml_views"=>"5", "html_views"=>"602"}
  • {"month"=>"12", "year"=>"2017", "pdf_views"=>"53", "xml_views"=>"2", "html_views"=>"120"}
  • {"month"=>"1", "year"=>"2018", "pdf_views"=>"73", "xml_views"=>"2", "html_views"=>"99"}
  • {"month"=>"2", "year"=>"2018", "pdf_views"=>"52", "xml_views"=>"0", "html_views"=>"75"}
  • {"month"=>"3", "year"=>"2018", "pdf_views"=>"52", "xml_views"=>"2", "html_views"=>"102"}
  • {"month"=>"4", "year"=>"2018", "pdf_views"=>"36", "xml_views"=>"0", "html_views"=>"90"}
  • {"month"=>"5", "year"=>"2018", "pdf_views"=>"49", "xml_views"=>"0", "html_views"=>"96"}
  • {"month"=>"6", "year"=>"2018", "pdf_views"=>"51", "xml_views"=>"0", "html_views"=>"65"}
  • {"month"=>"7", "year"=>"2018", "pdf_views"=>"26", "xml_views"=>"0", "html_views"=>"64"}
  • {"month"=>"8", "year"=>"2018", "pdf_views"=>"30", "xml_views"=>"1", "html_views"=>"53"}
  • {"month"=>"9", "year"=>"2018", "pdf_views"=>"37", "xml_views"=>"2", "html_views"=>"75"}
  • {"month"=>"10", "year"=>"2018", "pdf_views"=>"57", "xml_views"=>"1", "html_views"=>"74"}
  • {"month"=>"11", "year"=>"2018", "pdf_views"=>"38", "xml_views"=>"0", "html_views"=>"52"}
  • {"month"=>"12", "year"=>"2018", "pdf_views"=>"36", "xml_views"=>"0", "html_views"=>"55"}
  • {"month"=>"1", "year"=>"2019", "pdf_views"=>"25", "xml_views"=>"0", "html_views"=>"54"}
  • {"month"=>"2", "year"=>"2019", "pdf_views"=>"30", "xml_views"=>"0", "html_views"=>"54"}
  • {"month"=>"3", "year"=>"2019", "pdf_views"=>"36", "xml_views"=>"4", "html_views"=>"72"}
  • {"month"=>"4", "year"=>"2019", "pdf_views"=>"25", "xml_views"=>"2", "html_views"=>"39"}
  • {"month"=>"5", "year"=>"2019", "pdf_views"=>"25", "xml_views"=>"0", "html_views"=>"53"}
  • {"month"=>"6", "year"=>"2019", "pdf_views"=>"18", "xml_views"=>"0", "html_views"=>"41"}
  • {"month"=>"7", "year"=>"2019", "pdf_views"=>"28", "xml_views"=>"1", "html_views"=>"43"}
  • {"month"=>"8", "year"=>"2019", "pdf_views"=>"20", "xml_views"=>"0", "html_views"=>"37"}
  • {"month"=>"9", "year"=>"2019", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"19"}

PMC Usage Stats

  • {"unique-ip"=>"75", "full-text"=>"76", "pdf"=>"40", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"23", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"11"}
  • {"unique-ip"=>"41", "full-text"=>"36", "pdf"=>"18", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"30", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"12"}
  • {"unique-ip"=>"44", "full-text"=>"39", "pdf"=>"24", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"11", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"1"}
  • {"unique-ip"=>"35", "full-text"=>"26", "pdf"=>"15", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"26", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"3"}
  • {"unique-ip"=>"27", "full-text"=>"26", "pdf"=>"10", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"1"}
  • {"unique-ip"=>"37", "full-text"=>"41", "pdf"=>"22", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"4"}
  • {"unique-ip"=>"30", "full-text"=>"31", "pdf"=>"8", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"5"}
  • {"unique-ip"=>"29", "full-text"=>"35", "pdf"=>"8", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"6"}
  • {"unique-ip"=>"32", "full-text"=>"36", "pdf"=>"13", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"7"}
  • {"unique-ip"=>"37", "full-text"=>"37", "pdf"=>"10", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"8"}
  • {"unique-ip"=>"33", "full-text"=>"33", "pdf"=>"8", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"9"}
  • {"unique-ip"=>"29", "full-text"=>"32", "pdf"=>"8", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2018", "month"=>"11"}
  • {"unique-ip"=>"20", "full-text"=>"20", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"10"}
  • {"unique-ip"=>"25", "full-text"=>"22", "pdf"=>"8", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"12"}
  • {"unique-ip"=>"24", "full-text"=>"24", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"2"}
  • {"unique-ip"=>"34", "full-text"=>"32", "pdf"=>"13", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"3"}
  • {"unique-ip"=>"33", "full-text"=>"31", "pdf"=>"17", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"4"}
  • {"unique-ip"=>"25", "full-text"=>"25", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2019", "month"=>"5"}
Loading … Spinner
There are currently no alerts