A maximum-entropy model for predicting chromatin contacts
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{"title"=>"A maximum-entropy model for predicting chromatin contacts", "type"=>"journal", "authors"=>[{"first_name"=>"Pau", "last_name"=>"Farré", "scopus_author_id"=>"55355004900"}, {"first_name"=>"Eldon", "last_name"=>"Emberly", "scopus_author_id"=>"6604067883"}], "year"=>2018, "source"=>"PLoS Computational Biology", "identifiers"=>{"issn"=>"15537358", "doi"=>"10.1371/journal.pcbi.1005956", "sgr"=>"85042699053", "scopus"=>"2-s2.0-85042699053", "isbn"=>"1111111111", "pui"=>"620982116"}, "id"=>"db861ed2-9943-3baa-9e98-b74c1bd99429", "abstract"=>"The packaging of DNA inside a nucleus shows complex structure stabilized by a host of DNA-bound factors. Both the distribution of these factors and the contacts between different genomic locations of the DNA can now be measured on a genome-wide scale. This has advanced the development of models aimed at predicting the conformation of DNA given only the locations of bound factors—the chromatin folding problem. Here we present a maximum-entropy model that is able to predict a contact map representation of structure given a sequence of bound factors. Non-local effects due to the sequence neighborhood around contacting sites are found to be important for making accurate predictions. Lastly, we show that the model can be used to infer a sequence of bound factors given only a measurement of structure. This opens up the possibility for efficiently predicting sequence regions that may play a role in generating cell-type specific structural differences.", "link"=>"http://www.mendeley.com/research/maximumentropy-model-predicting-chromatin-contacts", "reader_count"=>23, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Researcher"=>7, "Student > Doctoral Student"=>3, "Student > Ph. D. Student"=>3, "Other"=>2, "Student > Master"=>2, "Student > Bachelor"=>3, "Professor > Associate Professor"=>1, "Lecturer > Senior Lecturer"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Researcher"=>7, "Student > Doctoral Student"=>3, "Student > Ph. D. Student"=>3, "Other"=>2, "Student > Master"=>2, "Student > Bachelor"=>3, "Professor > Associate Professor"=>1, "Lecturer > Senior Lecturer"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>2, "Biochemistry, Genetics and Molecular Biology"=>6, "Agricultural and Biological Sciences"=>9, "Chemical Engineering"=>1, "Physics and Astronomy"=>2, "Chemistry"=>1, "Computer Science"=>1, "Arts and Humanities"=>1}, "reader_count_by_subdiscipline"=>{"Chemistry"=>{"Chemistry"=>1}, "Physics and Astronomy"=>{"Physics and Astronomy"=>2}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>9}, "Computer Science"=>{"Computer Science"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>6}, "Unspecified"=>{"Unspecified"=>2}, "Chemical Engineering"=>{"Chemical Engineering"=>1}, "Arts and Humanities"=>{"Arts and Humanities"=>1}}, "group_count"=>0}

Scopus | Further Information

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