Genome-Wide Association Scan Meta-Analysis Identifies Three Loci Influencing Adiposity and Fat Distribution
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{"title"=>"Genome-wide association scan meta-analysis identifies three loci influencing adiposity and fat distribution", "type"=>"journal", "authors"=>[{"first_name"=>"Cecilia M.", "last_name"=>"Lindgren", "scopus_author_id"=>"7005443464"}, {"first_name"=>"Iris M.", "last_name"=>"Heid", "scopus_author_id"=>"6602566084"}, {"first_name"=>"Joshua C.", "last_name"=>"Randall", "scopus_author_id"=>"24333072700"}, {"first_name"=>"Claudia", "last_name"=>"Lamina", "scopus_author_id"=>"8719427400"}, {"first_name"=>"Valgerdur", "last_name"=>"Steinthorsdottir", "scopus_author_id"=>"6603006510"}, {"first_name"=>"Lu", "last_name"=>"Qi", "scopus_author_id"=>"8546476700"}, {"first_name"=>"Elizabeth K.", "last_name"=>"Speliotes", "scopus_author_id"=>"6507672576"}, {"first_name"=>"Gudmar", "last_name"=>"Thorleifsson", "scopus_author_id"=>"7003411255"}, {"first_name"=>"Cristen J.", "last_name"=>"Willer", "scopus_author_id"=>"6602404452"}, {"first_name"=>"Blanca M.", "last_name"=>"Herrera", "scopus_author_id"=>"8859807100"}, {"first_name"=>"Anne U.", "last_name"=>"Jackson", "scopus_author_id"=>"7402785538"}, {"first_name"=>"Noha", "last_name"=>"Lim", "scopus_author_id"=>"57196659238"}, {"first_name"=>"Paul", "last_name"=>"Scheet", "scopus_author_id"=>"6507478363"}, {"first_name"=>"Nicole", "last_name"=>"Soranzo", "scopus_author_id"=>"55800239500"}, {"first_name"=>"Najaf", "last_name"=>"Amin", "scopus_author_id"=>"24329223700"}, {"first_name"=>"Yurii S.", "last_name"=>"Aulchenko", "scopus_author_id"=>"6603626351"}, {"first_name"=>"John C.", "last_name"=>"Chambers", "scopus_author_id"=>"56676464600"}, {"first_name"=>"Alexander", "last_name"=>"Drong", "scopus_author_id"=>"28767683600"}, {"first_name"=>"Jia N.an", "last_name"=>"Luan", "scopus_author_id"=>"57196776921"}, {"first_name"=>"Helen N.", "last_name"=>"Lyon", "scopus_author_id"=>"7006097279"}, {"first_name"=>"Fernando", "last_name"=>"Rivadeneira", "scopus_author_id"=>"7801419664"}, {"first_name"=>"Serena", "last_name"=>"Sanna", "scopus_author_id"=>"16646989300"}, {"first_name"=>"Nicholas J.", "last_name"=>"Timpson", "scopus_author_id"=>"35355373400"}, {"first_name"=>"M. 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Erich", "last_name"=>"Wichmann", "scopus_author_id"=>"7102574024"}, {"first_name"=>"Timothy M.", "last_name"=>"Frayling", "scopus_author_id"=>"7003962934"}, {"first_name"=>"Gonçalo R.", "last_name"=>"Abecasis", "scopus_author_id"=>"56521788900"}, {"first_name"=>"Joel N.", "last_name"=>"Hirschhorn", "scopus_author_id"=>"7006710354"}, {"first_name"=>"Ruth J.F.", "last_name"=>"Loos", "scopus_author_id"=>"7006771047"}, {"first_name"=>"Kari", "last_name"=>"Stefansson", "scopus_author_id"=>"7005997553"}, {"first_name"=>"Karen L.", "last_name"=>"Mohlke", "scopus_author_id"=>"6602935932"}, {"first_name"=>"Inês", "last_name"=>"Barroso", "scopus_author_id"=>"55400421600"}, {"first_name"=>"Mark I.", "last_name"=>"McCarthy", "scopus_author_id"=>"7402061249"}], "year"=>2009, "source"=>"PLoS Genetics", "identifiers"=>{"scopus"=>"2-s2.0-67651236725", "sgr"=>"67651236725", "issn"=>"15537390", "arxiv"=>"arXiv:1011.1669v3", "doi"=>"10.1371/journal.pgen.1000508", "pmid"=>"19557161", "isbn"=>"0021-9630", "pui"=>"354995718"}, "id"=>"c1b94e82-c34e-34f4-80dd-62ad06d77547", "abstract"=>"To identify genetic loci influencing central obesity and fat distribution, we performed a meta-analysis of 16 genome-wide association studies (GWAS, N = 38,580) informative for adult waist circumference (WC) and waist-hip ratio (WHR). We selected 26 SNPs for follow-up, for which the evidence of association with measures of central adiposity (WC and/or WHR) was strong and disproportionate to that for overall adiposity or height. Follow-up studies in a maximum of 70,689 individuals identified two loci strongly associated with measures of central adiposity; these map near TFAP2B (WC, P = 1.9x10(-11)) and MSRA (WC, P = 8.9x10(-9)). A third locus, near LYPLAL1, was associated with WHR in women only (P = 2.6x10(-8)). The variants near TFAP2B appear to influence central adiposity through an effect on overall obesity/fat-mass, whereas LYPLAL1 displays a strong female-only association with fat distribution. By focusing on anthropometric measures of central obesity and fat distribution, we have identified three loci implicated in the regulation of human adiposity.", "link"=>"http://www.mendeley.com/research/genomewide-association-scan-metaanalysis-identifies-three-loci-influencing-adiposity-fat-distributio-2", "reader_count"=>245, "reader_count_by_academic_status"=>{"Unspecified"=>7, "Professor > Associate Professor"=>10, "Librarian"=>1, "Researcher"=>71, "Student > Doctoral Student"=>11, "Student > Ph. D. Student"=>59, "Student > Postgraduate"=>12, "Other"=>6, "Student > Master"=>24, "Student > Bachelor"=>15, "Lecturer"=>5, "Lecturer > Senior Lecturer"=>3, "Professor"=>21}, "reader_count_by_user_role"=>{"Unspecified"=>7, "Professor > Associate Professor"=>10, "Librarian"=>1, "Researcher"=>71, "Student > Doctoral Student"=>11, "Student > Ph. D. 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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/892904"], "description"=>"<p>We started out with a meta-analysis of GWAS data from 16 cohorts comprising 38,580 individuals informative for WC and 37,670 for WHR. We selected 23 SNPs of our top signals based on the following criteria (<a href=\"http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1000508#pgen.1000508.s002\" target=\"_blank\">Table S2</a>): preliminary stage 1 meta-analysis P-value≤10<sup>−5</sup>, BMI P-value>0.01 and height P-value>5×10<sup>−3</sup>. We supplemented these 23 independent loci (r<sup>2</sup><0.2) SNPs with three additional candidate signals. Further, we excluded recently reported BMI loci (<a href=\"http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1000508#pgen.1000508.s010\" target=\"_blank\">Table S10</a>) <a href=\"http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1000508#pgen.1000508-Frayling1\" target=\"_blank\">[10]</a>, <a href=\"http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1000508#pgen.1000508-Loos1\" target=\"_blank\">[14]</a>, <a href=\"http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1000508#pgen.1000508-Willer1\" target=\"_blank\">[16]</a>–<a href=\"http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1000508#pgen.1000508-Thorleifsson1\" target=\"_blank\">[17]</a>. These 26 SNPs were followed up in our stage 2 samples (N = maximum of 70,689 individuals). Further, we sought to confirm WC signals reaching genome wide significance in the combined analysis of stage 1 and 2 data in GWA data from the CHARGE consortium (for which WHR was not available). The data from the Rotterdam and ERF cohorts (up to 6,702 individuals) which were included in both CHARGE and stage 2 data, were counted only once in the overall analysis.</p>", "links"=>[], "tags"=>["diabetes and endocrinology", "diabetes and endocrinology/obesity", "diabetes and endocrinology/type 2 diabetes", "genetics and genomics", "genetics and genomics/complex traits"], "article_id"=>563136, "categories"=>["Chemistry", "Computational Biology", "Genetics", "Virology"], "users"=>["Cecilia M. Lindgren", "Iris M. Heid", "Joshua C. Randall", "Claudia Lamina", "Valgerdur Steinthorsdottir", "Lu Qi", "Elizabeth K. Speliotes", "Gudmar Thorleifsson", "Cristen J. Willer", "Blanca M. Herrera", "Anne U. Jackson", "Noha Lim", "Paul Scheet", "Nicole Soranzo", "Najaf Amin", "Yurii S. Aulchenko", "John C. Chambers", "Alexander Drong", "Jian'an Luan", "Helen N. Lyon", "Fernando Rivadeneira", "Serena Sanna", "Nicholas J. Timpson", "M. Carola Zillikens", "Jing Hua Zhao", "Peter Almgren", "Stefania Bandinelli", "Amanda J. Bennett", "Richard N. Bergman", "Lori L. Bonnycastle", "Suzannah J. Bumpstead", "Stephen J. Chanock", "Lynn Cherkas", "Peter Chines", "Lachlan Coin", "Cyrus Cooper", "Gabriel Crawford", "Angela Doering", "Anna Dominiczak", "Alex S. F. Doney", "Shah Ebrahim", "Paul Elliott", "Michael R. Erdos", "Karol Estrada", "Luigi Ferrucci", "Guido Fischer", "Nita G. Forouhi", "Christian Gieger", "Harald Grallert", "Christopher J. Groves", "Scott Grundy", "Candace Guiducci", "David Hadley", "Anders Hamsten", "Aki S. Havulinna", "Albert Hofman", "Rolf Holle", "John W. Holloway", "Thomas Illig", "Bo Isomaa", "Leonie C. Jacobs", "Karen Jameson", "Pekka Jousilahti", "Fredrik Karpe", "Johanna Kuusisto", "Jaana Laitinen", "G. Mark Lathrop", "Debbie A. Lawlor", "Massimo Mangino", "Wendy L. McArdle", "Thomas Meitinger", "Mario A. Morken", "Andrew P. Morris", "Patricia Munroe", "Narisu Narisu", "Anna Nordström", "Peter Nordström", "Ben A. Oostra", "Colin N. A. Palmer", "Felicity Payne", "John F. Peden", "Inga Prokopenko", "Frida Renström", "Aimo Ruokonen", "Veikko Salomaa", "Manjinder S. Sandhu", "Laura J. Scott", "Angelo Scuteri", "Kaisa Silander", "Kijoung Song", "Xin Yuan", "Heather M. Stringham", "Amy J. Swift", "Tiinamaija Tuomi", "Manuela Uda", "Peter Vollenweider", "Gérard Waeber", "Chris Wallace", "G. Bragi Walters", "Michael N. Weedon", "Jacqueline C. M. Witteman", "Cuilin Zhang", "Weihua Zhang", "Mark J. Caulfield", "Francis S. Collins", "George Davey Smith", "Ian N. M. Day", "Paul W. Franks", "Andrew T. Hattersley", "Frank B. Hu", "Marjo-Riitta Jarvelin", "Augustine Kong", "Jaspal S. Kooner", "Markku Laakso", "Edward Lakatta", "Vincent Mooser", "Andrew D. Morris", "Leena Peltonen", "Nilesh J. Samani", "Timothy D. Spector", "David P. Strachan", "Toshiko Tanaka", "Jaakko Tuomilehto", "Andre G. Uitterlinden", "Cornelia M. van Duijn", "Nicholas J. Wareham", "Hugh Watkins for the PROCARDIS consortia", "Dawn M. Waterworth", "Michael Boehnke", "Panos Deloukas", "Leif Groop", "David J. Hunter", "Unnur Thorsteinsdottir", "David Schlessinger", "H.-Erich Wichmann", "Timothy M. Frayling", "Gonçalo R. Abecasis", "Joel N. Hirschhorn", "Ruth J. F. Loos", "Kari Stefansson", "Karen L. Mohlke", "Inês Barroso", "Mark I. McCarthy for the GIANT consortium"], "doi"=>"https://dx.doi.org/10.1371/journal.pgen.1000508.g001", "stats"=>{"downloads"=>0, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Project_outline_/563136", "title"=>"Project outline.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2009-06-26 00:52:16"}
  • {"files"=>["https://ndownloader.figshare.com/files/442663", "https://ndownloader.figshare.com/files/442673", "https://ndownloader.figshare.com/files/442687", "https://ndownloader.figshare.com/files/442700", "https://ndownloader.figshare.com/files/442711", "https://ndownloader.figshare.com/files/442721", "https://ndownloader.figshare.com/files/442731", "https://ndownloader.figshare.com/files/442745", "https://ndownloader.figshare.com/files/442752", "https://ndownloader.figshare.com/files/442766", "https://ndownloader.figshare.com/files/442776"], "description"=>"<div><p>To identify genetic loci influencing central obesity and fat distribution, we performed a meta-analysis of 16 genome-wide association studies (GWAS, N = 38,580) informative for adult waist circumference (WC) and waist–hip ratio (WHR). We selected 26 SNPs for follow-up, for which the evidence of association with measures of central adiposity (WC and/or WHR) was strong and disproportionate to that for overall adiposity or height. Follow-up studies in a maximum of 70,689 individuals identified two loci strongly associated with measures of central adiposity; these map near <em>TFAP2B</em> (WC, <em>P</em> = 1.9×10<sup>−11</sup>) and <em>MSRA</em> (WC, <em>P</em> = 8.9×10<sup>−9</sup>). A third locus, near <em>LYPLAL1</em>, was associated with WHR in women only (<em>P</em> = 2.6×10<sup>−8</sup>). The variants near <em>TFAP2B</em> appear to influence central adiposity through an effect on overall obesity/fat-mass, whereas <em>LYPLAL1</em> displays a strong female-only association with fat distribution. By focusing on anthropometric measures of central obesity and fat distribution, we have identified three loci implicated in the regulation of human adiposity.</p></div>", "links"=>[], "tags"=>["genome-wide", "meta-analysis", "identifies", "loci", "influencing", "adiposity"], "article_id"=>147189, "categories"=>["Chemistry", "Biological Sciences", "Genetics", "Cancer"], "users"=>["Cecilia M. Lindgren", "Iris M. Heid", "Joshua C. Randall", "Claudia Lamina", "Valgerdur Steinthorsdottir", "Lu Qi", "Elizabeth K. Speliotes", "Gudmar Thorleifsson", "Cristen J. Willer", "Blanca M. Herrera", "Anne U. Jackson", "Noha Lim", "Paul Scheet", "Nicole Soranzo", "Najaf Amin", "Yurii S. Aulchenko", "John C. Chambers", "Alexander Drong", "Jian'an Luan", "Helen N. Lyon", "Fernando Rivadeneira", "Serena Sanna", "Nicholas J. Timpson", "M. Carola Zillikens", "Jing Hua Zhao", "Peter Almgren", "Stefania Bandinelli", "Amanda J. Bennett", "Richard N. Bergman", "Lori L. Bonnycastle", "Suzannah J. Bumpstead", "Stephen J. Chanock", "Lynn Cherkas", "Peter Chines", "Lachlan Coin", "Cyrus Cooper", "Gabriel Crawford", "Angela Doering", "Anna Dominiczak", "Alex S. F. Doney", "Shah Ebrahim", "Paul Elliott", "Michael R. Erdos", "Karol Estrada", "Luigi Ferrucci", "Guido Fischer", "Nita G. Forouhi", "Christian Gieger", "Harald Grallert", "Christopher J. Groves", "Scott Grundy", "Candace Guiducci", "David Hadley", "Anders Hamsten", "Aki S. Havulinna", "Albert Hofman", "Rolf Holle", "John W. Holloway", "Thomas Illig", "Bo Isomaa", "Leonie C. Jacobs", "Karen Jameson", "Pekka Jousilahti", "Fredrik Karpe", "Johanna Kuusisto", "Jaana Laitinen", "G. Mark Lathrop", "Debbie A. Lawlor", "Massimo Mangino", "Wendy L. McArdle", "Thomas Meitinger", "Mario A. Morken", "Andrew P. Morris", "Patricia Munroe", "Narisu Narisu", "Anna Nordström", "Peter Nordström", "Ben A. Oostra", "Colin N. A. Palmer", "Felicity Payne", "John F. Peden", "Inga Prokopenko", "Frida Renström", "Aimo Ruokonen", "Veikko Salomaa", "Manjinder S. Sandhu", "Laura J. Scott", "Angelo Scuteri", "Kaisa Silander", "Kijoung Song", "Xin Yuan", "Heather M. Stringham", "Amy J. Swift", "Tiinamaija Tuomi", "Manuela Uda", "Peter Vollenweider", "Gérard Waeber", "Chris Wallace", "G. Bragi Walters", "Michael N. Weedon", "Jacqueline C. M. Witteman", "Cuilin Zhang", "Weihua Zhang", "Mark J. Caulfield", "Francis S. Collins", "George Davey Smith", "Ian N. M. Day", "Paul W. Franks", "Andrew T. Hattersley", "Frank B. Hu", "Marjo-Riitta Jarvelin", "Augustine Kong", "Jaspal S. Kooner", "Markku Laakso", "Edward Lakatta", "Vincent Mooser", "Andrew D. Morris", "Leena Peltonen", "Nilesh J. Samani", "Timothy D. Spector", "David P. Strachan", "Toshiko Tanaka", "Jaakko Tuomilehto", "Andre G. Uitterlinden", "Cornelia M. van Duijn", "Nicholas J. Wareham", "Hugh Watkins for the PROCARDIS consortia", "Dawn M. Waterworth", "Michael Boehnke", "Panos Deloukas", "Leif Groop", "David J. Hunter", "Unnur Thorsteinsdottir", "David Schlessinger", "H.-Erich Wichmann", "Timothy M. Frayling", "Gonçalo R. Abecasis", "Joel N. Hirschhorn", "Ruth J. F. Loos", "Kari Stefansson", "Karen L. Mohlke", "Inês Barroso", "Mark I. McCarthy for the GIANT consortium"], "doi"=>["https://dx.doi.org/10.1371/journal.pgen.1000508.s001", "https://dx.doi.org/10.1371/journal.pgen.1000508.s002", "https://dx.doi.org/10.1371/journal.pgen.1000508.s003", "https://dx.doi.org/10.1371/journal.pgen.1000508.s004", "https://dx.doi.org/10.1371/journal.pgen.1000508.s005", "https://dx.doi.org/10.1371/journal.pgen.1000508.s006", "https://dx.doi.org/10.1371/journal.pgen.1000508.s007", "https://dx.doi.org/10.1371/journal.pgen.1000508.s008", "https://dx.doi.org/10.1371/journal.pgen.1000508.s009", "https://dx.doi.org/10.1371/journal.pgen.1000508.s010", "https://dx.doi.org/10.1371/journal.pgen.1000508.s011"], "stats"=>{"downloads"=>52, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Genome_Wide_Association_Scan_Meta_Analysis_Identifies_Three_Loci_Influencing_Adiposity_and_Fat_Distribution/147189", "title"=>"Genome-Wide Association Scan Meta-Analysis Identifies Three Loci Influencing Adiposity and Fat Distribution", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2009-06-26 01:59:49"}
  • {"files"=>["https://ndownloader.figshare.com/files/893899"], "description"=>"<p>Alleles: the first allele listed in the parenthesis is the effect allele, for which the allele frequency is given.</p><p>Stage 1: data from stage 1 GIANT GWAS meta-analysis.</p><p>Stage 2a: data from meta-analysis of <i>in silico</i> studies.</p><p>Stage 2b: data from meta-analysis of <i>de novo</i> genotyped studies.</p><p>Stage 1+2: data from stage 1 GIANT analyzed with <i>in silico</i> studies (Stage 2a) and <i>de novo</i> genotyped studies (Stage 2b).</p><p>Overall: data from meta-analysis of Stage1, 2a, 2b and CHARGE.</p>*<p>Total sample sizes do not always reflect the sum of component studies due to (a) rounding errors in non-integeric sample sizes arising from the weighting procedure; (b) overlap, for some markers, of data from the Rotterdam and ERF cohorts (up to 6,702 individuals) which were included in both CHARGE and stage 2 data, but which are counted only once in the overall analysis.</p>**<p>P-values: all P-values we report here are two-sided.</p>†<p>For the <i>MRSA</i> locus, genotypes for rs7826222 were only available for a subset of the CHARGE samples (N = 8,097). This is likely due to the fact that this SNP has been renamed to rs545854 in NCBI build 36 and was consequently one of the SNPs omitted from HapMap release 22 and therefore is not present in build 36 imputations based on that release of HapMap.</p><p>- Data not available. Effect size estimates and overall WHR results are not available as CHARGE only analysed WC using the weighted Z-score method (see <a href=\"http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1000508#s3\" target=\"_blank\">Methods</a>).</p>", "links"=>[], "tags"=>["genome-wide", "adiposity"], "article_id"=>564160, "categories"=>["Chemistry", "Computational Biology", "Genetics", "Virology"], "users"=>["Cecilia M. Lindgren", "Iris M. Heid", "Joshua C. Randall", "Claudia Lamina", "Valgerdur Steinthorsdottir", "Lu Qi", "Elizabeth K. Speliotes", "Gudmar Thorleifsson", "Cristen J. Willer", "Blanca M. Herrera", "Anne U. Jackson", "Noha Lim", "Paul Scheet", "Nicole Soranzo", "Najaf Amin", "Yurii S. Aulchenko", "John C. Chambers", "Alexander Drong", "Jian'an Luan", "Helen N. Lyon", "Fernando Rivadeneira", "Serena Sanna", "Nicholas J. Timpson", "M. Carola Zillikens", "Jing Hua Zhao", "Peter Almgren", "Stefania Bandinelli", "Amanda J. Bennett", "Richard N. Bergman", "Lori L. Bonnycastle", "Suzannah J. Bumpstead", "Stephen J. Chanock", "Lynn Cherkas", "Peter Chines", "Lachlan Coin", "Cyrus Cooper", "Gabriel Crawford", "Angela Doering", "Anna Dominiczak", "Alex S. F. Doney", "Shah Ebrahim", "Paul Elliott", "Michael R. Erdos", "Karol Estrada", "Luigi Ferrucci", "Guido Fischer", "Nita G. Forouhi", "Christian Gieger", "Harald Grallert", "Christopher J. Groves", "Scott Grundy", "Candace Guiducci", "David Hadley", "Anders Hamsten", "Aki S. Havulinna", "Albert Hofman", "Rolf Holle", "John W. Holloway", "Thomas Illig", "Bo Isomaa", "Leonie C. Jacobs", "Karen Jameson", "Pekka Jousilahti", "Fredrik Karpe", "Johanna Kuusisto", "Jaana Laitinen", "G. Mark Lathrop", "Debbie A. Lawlor", "Massimo Mangino", "Wendy L. McArdle", "Thomas Meitinger", "Mario A. Morken", "Andrew P. Morris", "Patricia Munroe", "Narisu Narisu", "Anna Nordström", "Peter Nordström", "Ben A. Oostra", "Colin N. A. Palmer", "Felicity Payne", "John F. Peden", "Inga Prokopenko", "Frida Renström", "Aimo Ruokonen", "Veikko Salomaa", "Manjinder S. Sandhu", "Laura J. Scott", "Angelo Scuteri", "Kaisa Silander", "Kijoung Song", "Xin Yuan", "Heather M. Stringham", "Amy J. Swift", "Tiinamaija Tuomi", "Manuela Uda", "Peter Vollenweider", "Gérard Waeber", "Chris Wallace", "G. Bragi Walters", "Michael N. Weedon", "Jacqueline C. M. Witteman", "Cuilin Zhang", "Weihua Zhang", "Mark J. Caulfield", "Francis S. Collins", "George Davey Smith", "Ian N. M. Day", "Paul W. Franks", "Andrew T. Hattersley", "Frank B. Hu", "Marjo-Riitta Jarvelin", "Augustine Kong", "Jaspal S. Kooner", "Markku Laakso", "Edward Lakatta", "Vincent Mooser", "Andrew D. Morris", "Leena Peltonen", "Nilesh J. Samani", "Timothy D. Spector", "David P. Strachan", "Toshiko Tanaka", "Jaakko Tuomilehto", "Andre G. Uitterlinden", "Cornelia M. van Duijn", "Nicholas J. Wareham", "Hugh Watkins for the PROCARDIS consortia", "Dawn M. Waterworth", "Michael Boehnke", "Panos Deloukas", "Leif Groop", "David J. Hunter", "Unnur Thorsteinsdottir", "David Schlessinger", "H.-Erich Wichmann", "Timothy M. Frayling", "Gonçalo R. Abecasis", "Joel N. Hirschhorn", "Ruth J. F. Loos", "Kari Stefansson", "Karen L. Mohlke", "Inês Barroso", "Mark I. McCarthy for the GIANT consortium"], "doi"=>"https://dx.doi.org/10.1371/journal.pgen.1000508.t001", "stats"=>{"downloads"=>0, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_SNPs_with_genome_wide_significant_evidence_for_association_with_central_adiposity_and_fat_distribution_/564160", "title"=>"SNPs with genome-wide significant evidence for association with central adiposity and fat distribution.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2009-06-26 01:09:20"}
  • {"files"=>["https://ndownloader.figshare.com/files/893285"], "description"=>"<p>A. Manhattan plots showing significance of association of all SNPs in the Stage 1 GIANT meta-analysis with central obesity phenotypes. SNPs are plotted on the x-axis according to their position on each chromosome against association with central obesity measure (WC or WHR) on the y-axis (shown as −log10 P-value). SNPs that have been previously reported to show association with BMI is shown in blue <a href=\"http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1000508#pgen.1000508-Frayling1\" target=\"_blank\">[10]</a>,<a href=\"http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1000508#pgen.1000508-Loos1\" target=\"_blank\">[14]</a>,<a href=\"http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1000508#pgen.1000508-Willer1\" target=\"_blank\">[16]</a> and the two regions showing strong associations in the overall, non-gender-stratified analyses are shown in green. Other SNPs taken forward into stage 2 follow-up are indicated in red. B. Quantile-quantile (QQ) plots of SNPs; after Stage 1 GIANT meta-analysis (black) and after removing any SNPs surrounding the recently reported BMI loci <a href=\"http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1000508#pgen.1000508-Frayling1\" target=\"_blank\">[10]</a>, <a href=\"http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1000508#pgen.1000508-Loos1\" target=\"_blank\">[14]</a>, <a href=\"http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1000508#pgen.1000508-Willer1\" target=\"_blank\">[16]</a>–<a href=\"http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1000508#pgen.1000508-Thorleifsson1\" target=\"_blank\">[17]</a> (blue). The grey areas in the QQ plots represent the 95% confidence intervals around the test statistics and after excluding the recently reported BMI loci <a href=\"http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1000508#pgen.1000508-Frayling1\" target=\"_blank\">[10]</a>, <a href=\"http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1000508#pgen.1000508-Loos1\" target=\"_blank\">[14]</a>, <a href=\"http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1000508#pgen.1000508-Willer1\" target=\"_blank\">[16]</a>–<a href=\"http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1000508#pgen.1000508-Thorleifsson1\" target=\"_blank\">[17]</a>, there is no indication of excess of signal.</p>", "links"=>[], "tags"=>["diabetes and endocrinology", "diabetes and endocrinology/obesity", "diabetes and endocrinology/type 2 diabetes", "genetics and genomics", "genetics and genomics/complex traits"], "article_id"=>563529, "categories"=>["Chemistry", "Computational Biology", "Genetics", "Virology"], "users"=>["Cecilia M. Lindgren", "Iris M. Heid", "Joshua C. Randall", "Claudia Lamina", "Valgerdur Steinthorsdottir", "Lu Qi", "Elizabeth K. Speliotes", "Gudmar Thorleifsson", "Cristen J. Willer", "Blanca M. Herrera", "Anne U. Jackson", "Noha Lim", "Paul Scheet", "Nicole Soranzo", "Najaf Amin", "Yurii S. Aulchenko", "John C. Chambers", "Alexander Drong", "Jian'an Luan", "Helen N. Lyon", "Fernando Rivadeneira", "Serena Sanna", "Nicholas J. Timpson", "M. Carola Zillikens", "Jing Hua Zhao", "Peter Almgren", "Stefania Bandinelli", "Amanda J. Bennett", "Richard N. Bergman", "Lori L. Bonnycastle", "Suzannah J. Bumpstead", "Stephen J. Chanock", "Lynn Cherkas", "Peter Chines", "Lachlan Coin", "Cyrus Cooper", "Gabriel Crawford", "Angela Doering", "Anna Dominiczak", "Alex S. F. Doney", "Shah Ebrahim", "Paul Elliott", "Michael R. Erdos", "Karol Estrada", "Luigi Ferrucci", "Guido Fischer", "Nita G. Forouhi", "Christian Gieger", "Harald Grallert", "Christopher J. Groves", "Scott Grundy", "Candace Guiducci", "David Hadley", "Anders Hamsten", "Aki S. Havulinna", "Albert Hofman", "Rolf Holle", "John W. Holloway", "Thomas Illig", "Bo Isomaa", "Leonie C. Jacobs", "Karen Jameson", "Pekka Jousilahti", "Fredrik Karpe", "Johanna Kuusisto", "Jaana Laitinen", "G. Mark Lathrop", "Debbie A. Lawlor", "Massimo Mangino", "Wendy L. McArdle", "Thomas Meitinger", "Mario A. Morken", "Andrew P. Morris", "Patricia Munroe", "Narisu Narisu", "Anna Nordström", "Peter Nordström", "Ben A. Oostra", "Colin N. A. Palmer", "Felicity Payne", "John F. Peden", "Inga Prokopenko", "Frida Renström", "Aimo Ruokonen", "Veikko Salomaa", "Manjinder S. Sandhu", "Laura J. Scott", "Angelo Scuteri", "Kaisa Silander", "Kijoung Song", "Xin Yuan", "Heather M. Stringham", "Amy J. Swift", "Tiinamaija Tuomi", "Manuela Uda", "Peter Vollenweider", "Gérard Waeber", "Chris Wallace", "G. Bragi Walters", "Michael N. Weedon", "Jacqueline C. M. Witteman", "Cuilin Zhang", "Weihua Zhang", "Mark J. Caulfield", "Francis S. Collins", "George Davey Smith", "Ian N. M. Day", "Paul W. Franks", "Andrew T. Hattersley", "Frank B. Hu", "Marjo-Riitta Jarvelin", "Augustine Kong", "Jaspal S. Kooner", "Markku Laakso", "Edward Lakatta", "Vincent Mooser", "Andrew D. Morris", "Leena Peltonen", "Nilesh J. Samani", "Timothy D. Spector", "David P. Strachan", "Toshiko Tanaka", "Jaakko Tuomilehto", "Andre G. Uitterlinden", "Cornelia M. van Duijn", "Nicholas J. Wareham", "Hugh Watkins for the PROCARDIS consortia", "Dawn M. Waterworth", "Michael Boehnke", "Panos Deloukas", "Leif Groop", "David J. Hunter", "Unnur Thorsteinsdottir", "David Schlessinger", "H.-Erich Wichmann", "Timothy M. Frayling", "Gonçalo R. Abecasis", "Joel N. Hirschhorn", "Ruth J. F. Loos", "Kari Stefansson", "Karen L. Mohlke", "Inês Barroso", "Mark I. McCarthy for the GIANT consortium"], "doi"=>"https://dx.doi.org/10.1371/journal.pgen.1000508.g002", "stats"=>{"downloads"=>2, "page_views"=>12, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Genome_wide_association_results_for_GIANT_Stage_1_/563529", "title"=>"Genome-wide association results for GIANT (Stage 1).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2009-06-26 00:58:49"}
  • {"files"=>["https://ndownloader.figshare.com/files/893604"], "description"=>"<p>SNPs are plotted by position on chromosome against association (−log10 p-value) with central obesity phenotype (WC or WHR) using stage 1 (GWAS meta-analysis) data. In the case of panel (b), analyses are restricted to women only. In each panel, the SNP with the strongest association based on stage 1 data is denoted with a purple diamond: the P-value attached represents the final P-value attained across all available data (<a href=\"http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1000508#pgen-1000508-t001\" target=\"_blank\">Table 1</a>). Estimated recombination rates (from HapMap-CEU) are plotted in purple to reflect the local LD structure on a secondary Y-axis. The SNPs surrounding the most significant SNP (purple diamond) are color-coded (see inset) to reflect their LD with this SNP (using pair-wise r<sup>2</sup> values from HapMap CEU). Genes and the position of exons, as well as the direction of transcription, are shown below the plots (using data from the UCSC genome browser, genome.ucsc.edu). The grey area marks the extent of the region that includes any SNP with r<sup>2</sup>≥0.3 relative to the SNP with the strongest stage 1 association signal. Hash marks represent SNP positions on each genotyping array used by any individual study and also show SNP positions after imputation.</p>", "links"=>[], "tags"=>["plots", "loci", "highlighted"], "article_id"=>563847, "categories"=>["Chemistry", "Computational Biology", "Genetics", "Virology"], "users"=>["Cecilia M. Lindgren", "Iris M. Heid", "Joshua C. Randall", "Claudia Lamina", "Valgerdur Steinthorsdottir", "Lu Qi", "Elizabeth K. Speliotes", "Gudmar Thorleifsson", "Cristen J. Willer", "Blanca M. Herrera", "Anne U. Jackson", "Noha Lim", "Paul Scheet", "Nicole Soranzo", "Najaf Amin", "Yurii S. Aulchenko", "John C. Chambers", "Alexander Drong", "Jian'an Luan", "Helen N. Lyon", "Fernando Rivadeneira", "Serena Sanna", "Nicholas J. Timpson", "M. Carola Zillikens", "Jing Hua Zhao", "Peter Almgren", "Stefania Bandinelli", "Amanda J. Bennett", "Richard N. Bergman", "Lori L. Bonnycastle", "Suzannah J. Bumpstead", "Stephen J. Chanock", "Lynn Cherkas", "Peter Chines", "Lachlan Coin", "Cyrus Cooper", "Gabriel Crawford", "Angela Doering", "Anna Dominiczak", "Alex S. F. Doney", "Shah Ebrahim", "Paul Elliott", "Michael R. Erdos", "Karol Estrada", "Luigi Ferrucci", "Guido Fischer", "Nita G. Forouhi", "Christian Gieger", "Harald Grallert", "Christopher J. Groves", "Scott Grundy", "Candace Guiducci", "David Hadley", "Anders Hamsten", "Aki S. Havulinna", "Albert Hofman", "Rolf Holle", "John W. Holloway", "Thomas Illig", "Bo Isomaa", "Leonie C. Jacobs", "Karen Jameson", "Pekka Jousilahti", "Fredrik Karpe", "Johanna Kuusisto", "Jaana Laitinen", "G. Mark Lathrop", "Debbie A. Lawlor", "Massimo Mangino", "Wendy L. McArdle", "Thomas Meitinger", "Mario A. Morken", "Andrew P. Morris", "Patricia Munroe", "Narisu Narisu", "Anna Nordström", "Peter Nordström", "Ben A. Oostra", "Colin N. A. Palmer", "Felicity Payne", "John F. Peden", "Inga Prokopenko", "Frida Renström", "Aimo Ruokonen", "Veikko Salomaa", "Manjinder S. Sandhu", "Laura J. Scott", "Angelo Scuteri", "Kaisa Silander", "Kijoung Song", "Xin Yuan", "Heather M. Stringham", "Amy J. Swift", "Tiinamaija Tuomi", "Manuela Uda", "Peter Vollenweider", "Gérard Waeber", "Chris Wallace", "G. Bragi Walters", "Michael N. Weedon", "Jacqueline C. M. Witteman", "Cuilin Zhang", "Weihua Zhang", "Mark J. Caulfield", "Francis S. Collins", "George Davey Smith", "Ian N. M. Day", "Paul W. Franks", "Andrew T. Hattersley", "Frank B. Hu", "Marjo-Riitta Jarvelin", "Augustine Kong", "Jaspal S. Kooner", "Markku Laakso", "Edward Lakatta", "Vincent Mooser", "Andrew D. Morris", "Leena Peltonen", "Nilesh J. Samani", "Timothy D. Spector", "David P. Strachan", "Toshiko Tanaka", "Jaakko Tuomilehto", "Andre G. Uitterlinden", "Cornelia M. van Duijn", "Nicholas J. Wareham", "Hugh Watkins for the PROCARDIS consortia", "Dawn M. Waterworth", "Michael Boehnke", "Panos Deloukas", "Leif Groop", "David J. Hunter", "Unnur Thorsteinsdottir", "David Schlessinger", "H.-Erich Wichmann", "Timothy M. Frayling", "Gonçalo R. Abecasis", "Joel N. Hirschhorn", "Ruth J. F. Loos", "Kari Stefansson", "Karen L. Mohlke", "Inês Barroso", "Mark I. McCarthy for the GIANT consortium"], "doi"=>"https://dx.doi.org/10.1371/journal.pgen.1000508.g003", "stats"=>{"downloads"=>0, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Regional_plots_of_loci_highlighted_in_this_study_/563847", "title"=>"Regional plots of loci highlighted in this study.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2009-06-26 01:04:07"}

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