A Mouse Model for the Metabolic Effects of the Human Fat Mass and Obesity Associated FTO Gene
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{"title"=>"A mouse model for the metabolic effects of the human fat mass and obesity associated FTO gene", "type"=>"journal", "authors"=>[{"first_name"=>"Chris", "last_name"=>"Church", "scopus_author_id"=>"35862809300"}, {"first_name"=>"Sheena", "last_name"=>"Lee", "scopus_author_id"=>"23485842700"}, {"first_name"=>"Eleanor A L", "last_name"=>"Bagg", "scopus_author_id"=>"24167822000"}, {"first_name"=>"James S.", "last_name"=>"McTaggart", "scopus_author_id"=>"35072926600"}, {"first_name"=>"Robert", "last_name"=>"Deacon", "scopus_author_id"=>"7004530169"}, {"first_name"=>"Thomas", "last_name"=>"Gerken", "scopus_author_id"=>"55966968900"}, {"first_name"=>"Angela", "last_name"=>"Lee", "scopus_author_id"=>"9233741700"}, {"first_name"=>"Lee", "last_name"=>"Moir", "scopus_author_id"=>"6602606060"}, {"first_name"=>"Jasmin", "last_name"=>"Mecinović", "scopus_author_id"=>"20433814400"}, {"first_name"=>"Mohamed M.", "last_name"=>"Quwailid", "scopus_author_id"=>"6505518455"}, {"first_name"=>"Christopher J.", "last_name"=>"Schofield", "scopus_author_id"=>"35461437200"}, {"first_name"=>"Frances M.", "last_name"=>"Ashcroft", "scopus_author_id"=>"7102011004"}, {"first_name"=>"Roger D.", "last_name"=>"Cox", "scopus_author_id"=>"7403419758"}], "year"=>2009, "source"=>"PLoS Genetics", "identifiers"=>{"pui"=>"355245414", "issn"=>"15537390", "isbn"=>"1553-7404 (Electronic)\\r1553-7390 (Linking)", "doi"=>"10.1371/journal.pgen.1000599", "scopus"=>"2-s2.0-70149100469", "pmid"=>"19680540", "sgr"=>"70149100469"}, "id"=>"b1b2da3a-1cea-3618-b294-139c6d8c9056", "abstract"=>"Human FTO gene variants are associated with body mass index and type 2 diabetes. Because the obesity-associated SNPs are intronic, it is unclear whether changes in FTO expression or splicing are the cause of obesity or if regulatory elements within intron 1 influence upstream or downstream genes. We tested the idea that FTO itself is involved in obesity. We show that a dominant point mutation in the mouse Fto gene results in reduced fat mass, increased energy expenditure, and unchanged physical activity. Exposure to a high-fat diet enhances lean mass and lowers fat mass relative to control mice. Biochemical studies suggest the mutation occurs in a structurally novel domain and modifies FTO function, possibly by altering its dimerisation state. Gene expression profiling revealed increased expression of some fat and carbohydrate metabolism genes and an improved inflammatory profile in white adipose tissue of mutant mice. These data provide direct functional evidence that FTO is a causal gene underlying obesity. Compared to the reported mouse FTO knockout, our model more accurately reflects the effect of human FTO variants; we observe a heterozygous as well as homozygous phenotype, a smaller difference in weight and adiposity, and our mice do not show perinatal lethality or an age-related reduction in size and length. Our model suggests that a search for human coding mutations in FTO may be informative and that inhibition of FTO activity is a possible target for the treatment of morbid obesity.", "link"=>"http://www.mendeley.com/research/mouse-model-metabolic-effects-human-fat-mass-obesity-associated-fto-gene-1", "reader_count"=>107, "reader_count_by_academic_status"=>{"Unspecified"=>2, "Professor > Associate Professor"=>6, "Researcher"=>19, "Student > Doctoral Student"=>5, "Student > Ph. D. Student"=>29, "Student > Postgraduate"=>4, "Student > Master"=>14, "Other"=>4, "Student > Bachelor"=>21, "Lecturer"=>2, "Professor"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>2, "Professor > Associate Professor"=>6, "Researcher"=>19, "Student > Doctoral Student"=>5, "Student > Ph. D. Student"=>29, "Student > Postgraduate"=>4, "Student > Master"=>14, "Other"=>4, "Student > Bachelor"=>21, "Lecturer"=>2, "Professor"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>3, "Agricultural and Biological Sciences"=>56, "Business, Management and Accounting"=>1, "Chemistry"=>6, "Computer Science"=>2, "Economics, Econometrics and Finance"=>1, "Environmental Science"=>1, "Biochemistry, Genetics and Molecular Biology"=>10, "Nursing and Health Professions"=>1, "Mathematics"=>1, "Medicine and Dentistry"=>21, "Neuroscience"=>1, "Pharmacology, Toxicology and Pharmaceutical Science"=>2, "Social Sciences"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>21}, "Social Sciences"=>{"Social Sciences"=>1}, "Mathematics"=>{"Mathematics"=>1}, "Unspecified"=>{"Unspecified"=>3}, "Environmental Science"=>{"Environmental Science"=>1}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>2}, "Chemistry"=>{"Chemistry"=>6}, "Neuroscience"=>{"Neuroscience"=>1}, "Economics, Econometrics and Finance"=>{"Economics, Econometrics and Finance"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>56}, "Computer Science"=>{"Computer Science"=>2}, "Business, Management and Accounting"=>{"Business, Management and Accounting"=>1}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>10}}, "reader_count_by_country"=>{"Canada"=>1, "United States"=>4, "Luxembourg"=>1, "United Kingdom"=>3, "Portugal"=>1, "Switzerland"=>1}, "group_count"=>5}

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/439983", "https://ndownloader.figshare.com/files/440025", "https://ndownloader.figshare.com/files/440052", "https://ndownloader.figshare.com/files/440078", "https://ndownloader.figshare.com/files/440107", "https://ndownloader.figshare.com/files/440137", "https://ndownloader.figshare.com/files/440164", "https://ndownloader.figshare.com/files/440192", "https://ndownloader.figshare.com/files/440229", "https://ndownloader.figshare.com/files/440267", "https://ndownloader.figshare.com/files/440301", "https://ndownloader.figshare.com/files/440335", "https://ndownloader.figshare.com/files/440379", "https://ndownloader.figshare.com/files/440400", "https://ndownloader.figshare.com/files/440426", "https://ndownloader.figshare.com/files/440461"], "description"=>"<div><p>Human <em>FTO</em> gene variants are associated with body mass index and type 2 diabetes. Because the obesity-associated SNPs are intronic, it is unclear whether changes in FTO expression or splicing are the cause of obesity or if regulatory elements within intron 1 influence upstream or downstream genes. We tested the idea that FTO itself is involved in obesity. We show that a dominant point mutation in the mouse <em>Fto</em> gene results in reduced fat mass, increased energy expenditure, and unchanged physical activity. Exposure to a high-fat diet enhances lean mass and lowers fat mass relative to control mice. Biochemical studies suggest the mutation occurs in a structurally novel domain and modifies FTO function, possibly by altering its dimerisation state. Gene expression profiling revealed increased expression of some fat and carbohydrate metabolism genes and an improved inflammatory profile in white adipose tissue of mutant mice. These data provide direct functional evidence that <em>FTO</em> is a causal gene underlying obesity. Compared to the reported mouse FTO knockout, our model more accurately reflects the effect of human <em>FTO</em> variants; we observe a heterozygous as well as homozygous phenotype, a smaller difference in weight and adiposity, and our mice do not show perinatal lethality or an age-related reduction in size and length. Our model suggests that a search for human coding mutations in <em>FTO</em> may be informative and that inhibition of FTO activity is a possible target for the treatment of morbid obesity.</p></div>", "links"=>[], "tags"=>["metabolic", "effects", "obesity"], "article_id"=>146732, "categories"=>["Genetics", "Biochemistry", "Cancer", "Physiology"], "users"=>["Chris Church", "Sheena Lee", "Eleanor A. L. Bagg", "James S. McTaggart", "Robert Deacon", "Thomas Gerken", "Angela Lee", "Lee Moir", "Jasmin Mecinović", "Mohamed M. Quwailid", "Christopher J. Schofield", "Frances M. Ashcroft", "Roger D. Cox"], "doi"=>["https://dx.doi.org/10.1371/journal.pgen.1000599.s001", "https://dx.doi.org/10.1371/journal.pgen.1000599.s002", "https://dx.doi.org/10.1371/journal.pgen.1000599.s003", "https://dx.doi.org/10.1371/journal.pgen.1000599.s004", "https://dx.doi.org/10.1371/journal.pgen.1000599.s005", "https://dx.doi.org/10.1371/journal.pgen.1000599.s006", "https://dx.doi.org/10.1371/journal.pgen.1000599.s007", "https://dx.doi.org/10.1371/journal.pgen.1000599.s008", "https://dx.doi.org/10.1371/journal.pgen.1000599.s009", "https://dx.doi.org/10.1371/journal.pgen.1000599.s010", "https://dx.doi.org/10.1371/journal.pgen.1000599.s011", "https://dx.doi.org/10.1371/journal.pgen.1000599.s012", "https://dx.doi.org/10.1371/journal.pgen.1000599.s013", "https://dx.doi.org/10.1371/journal.pgen.1000599.s014", "https://dx.doi.org/10.1371/journal.pgen.1000599.s015", "https://dx.doi.org/10.1371/journal.pgen.1000599.s016"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/A_Mouse_Model_for_the_Metabolic_Effects_of_the_Human_Fat_Mass_and_Obesity_Associated_FTO_Gene/146732", "title"=>"A Mouse Model for the Metabolic Effects of the Human Fat Mass and Obesity Associated <em>FTO</em> Gene", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2009-08-14 01:52:12"}
  • {"files"=>["https://ndownloader.figshare.com/files/887187"], "description"=>"<p>(A) Sequencing reveals an A to T mutation in exon 6 of FTO that leads to conversion of the isoleucine at residue 367 to phenylalanine. (B) Sequence line-up showing isoleucine 367 (arrow) and surrounding residues are highly conserved in vertebrates. Colour code for amino acids indicates a consensus residue derived from a block of similar residues (black), a completely conserved residue (red), a residue weakly similar to a consensus residue (orange), a consensus residue derived from the occurrence of greater than 50% of a single residue (blue) and non-similar residues (dark-red).</p>", "links"=>[], "tags"=>["enu-induced", "missense", "mutation", "i367f", "exon"], "article_id"=>557624, "categories"=>["Genetics", "Biochemistry", "Virology", "Physiology"], "users"=>["Chris Church", "Sheena Lee", "Eleanor A. L. Bagg", "James S. McTaggart", "Robert Deacon", "Thomas Gerken", "Angela Lee", "Lee Moir", "Jasmin Mecinović", "Mohamed M. Quwailid", "Christopher J. Schofield", "Frances M. Ashcroft", "Roger D. Cox"], "doi"=>["https://dx.doi.org/10.1371/journal.pgen.1000599.g001"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_An_ENU_induced_missense_mutation_I367F_in_exon_6_of_FTO_/557624", "title"=>"An ENU-induced missense mutation I367F in exon 6 of FTO.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2009-08-14 02:07:04"}
  • {"files"=>["https://ndownloader.figshare.com/files/887288"], "description"=>"<p>(A) mFTO<sup>I367A</sup> (light blue) shows reduced catalytic activity in a 2OG turnover assay with a 3-meT oligonucleotide substrate, compared to mFTO (dark blue). Neither CmFTO (purple) nor CmFTO<sup>I367A</sup> (grey) show significant 2OG turnover. Data are expressed as mean±SEM. (B) Non-denaturing electrospray ionisation mass spectrometry analyses showing the dimeric nature of (i) The <i>C-</i>terminal domain of mFTO (CmFTO), (ii) Full-length mFTO and (iii) Full-length human FTO. The twin peaks present in the CmFTO sample likely result from α-N-gluconylation of the protein resulting in partial formation of a+178Da adduct (see <a href=\"http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1000599#pgen.1000599.s001\" target=\"_blank\">Figure S1</a> and <a href=\"http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1000599#pgen.1000599.s002\" target=\"_blank\">Figure S2</a>). (C) Analytical gel filtration chromatogram showing the presence of two FTO species in solution. (i) mFTO (red) and mFTO<sup>I367A</sup> (blue), (ii) CmFTO (red) and CmFTO<sup>I367A</sup> (blue). (D) Circular dichroism spectra showing the secondary structures of mFTO (red), mFTO<sup>I367A</sup> (blue), CmFTO (green) and CmFTO<sup>I367A</sup> (black) at 0.25 mg/ml, 4°C.</p>", "links"=>[], "tags"=>["mutation"], "article_id"=>557736, "categories"=>["Genetics", "Biochemistry", "Virology", "Physiology"], "users"=>["Chris Church", "Sheena Lee", "Eleanor A. L. Bagg", "James S. McTaggart", "Robert Deacon", "Thomas Gerken", "Angela Lee", "Lee Moir", "Jasmin Mecinović", "Mohamed M. Quwailid", "Christopher J. Schofield", "Frances M. Ashcroft", "Roger D. Cox"], "doi"=>["https://dx.doi.org/10.1371/journal.pgen.1000599.g002"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_The_FTO_I367F_mutation_is_within_a_C_terminal_domain_/557736", "title"=>"The FTO<sup>I367F</sup> mutation is within a <i>C-</i>terminal domain.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2009-08-14 02:08:56"}
  • {"files"=>["https://ndownloader.figshare.com/files/887473"], "description"=>"<p>(A) Confocal fluorescence images of COS-7 cells expressing YFP, YFP-FTO and YFP-FTO<sup>I367F</sup>, as indicated. First column: YFP fluorescence. Second column: fluorescence from 4′,6-diamidino-2-phenylindole (DAPI), which stains nuclei. Third column: merged channels. (B) Western blot of protein from Cos cells expressing HA-FTO or HA-FTOI367F, as indicated, probed with an anti-HA antibody. Below, loading control of the same gel probed with an anti-TATA-binding protein (TBP) antibody. (C) Western blot of protein from liver and brain of wild-type (I/I), heterozygous (I/F) and homozygous (F/F) mice probed with a polyclonal rabbit anti-FTO antibody. Below, loading control of the same gel probed with an anti-actin antibody.</p>", "links"=>[], "tags"=>["levels", "localised"], "article_id"=>557918, "categories"=>["Genetics", "Biochemistry", "Virology", "Physiology"], "users"=>["Chris Church", "Sheena Lee", "Eleanor A. L. Bagg", "James S. McTaggart", "Robert Deacon", "Thomas Gerken", "Angela Lee", "Lee Moir", "Jasmin Mecinović", "Mohamed M. Quwailid", "Christopher J. Schofield", "Frances M. Ashcroft", "Roger D. Cox"], "doi"=>["https://dx.doi.org/10.1371/journal.pgen.1000599.g003"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_The_FTO_I367F_protein_is_expressed_at_lower_levels_and_localised_in_the_nucleus_/557918", "title"=>"The FTO<sup>I367F</sup> protein is expressed at lower levels and localised in the nucleus.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2009-08-14 02:11:58"}
  • {"files"=>["https://ndownloader.figshare.com/files/887624"], "description"=>"<p>(A) Body weights of male heterozygous (I/F; n = 21) and homozygous (F/F; n = 28) <i>Fto<sup>I367F</sup></i> mice and of wild-type littermates (I/I; n = 15). (B,C) Fat mass (B) and lean body mass (C) of 24-week old male heterozygous (n = 26), homozygous (n = 15) and wild-type (n = 12) mice. (D) Food intake over 24 hours normalised to body weight (BW) measured at 10 weeks (I/I, n = 20; I/F, n = 30; F/F, n = 15) and 20 weeks (I/I, n = 12; I/F, n = 20; F/F, n = 15). Data are expressed as mean±SEM, Statistical analysis was performed using Student's t-test. *, P<0.05; **, P<0.01 for differences between <i>Fto<sup>I367F</sup></i> heterozygous or homozygous mice and wild-type littermates.</p>", "links"=>[], "tags"=>["mice", "reduced"], "article_id"=>558069, "categories"=>["Genetics", "Biochemistry", "Virology", "Physiology"], "users"=>["Chris Church", "Sheena Lee", "Eleanor A. L. Bagg", "James S. McTaggart", "Robert Deacon", "Thomas Gerken", "Angela Lee", "Lee Moir", "Jasmin Mecinović", "Mohamed M. Quwailid", "Christopher J. Schofield", "Frances M. Ashcroft", "Roger D. Cox"], "doi"=>["https://dx.doi.org/10.1371/journal.pgen.1000599.g004"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Male_Fto_I367F_mice_exhibit_reduced_body_and_fat_mass_/558069", "title"=>"Male <i>Fto<sup>I367F</sup></i> mice exhibit reduced body and fat mass.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2009-08-14 02:14:29"}
  • {"files"=>["https://ndownloader.figshare.com/files/887742"], "description"=>"<p>(A,B) Oxygen Consumption (A i) and carbon dioxide production (B i) over a 22-hr period for 18-week old male heterozygous (I/F; n = 30) and homozygous (F/F; n = 15) <i>Fto<sup>I367F</sup></i> mice and wild-type littermates (I/I; n = 26). Inset, total oxygen consumption (A ii), and carbon dioxide production (B ii) over 22-hr. (C) Respiratory exchange ratio (RER) calculated from data given in A, B during the light and dark period. (D) Physical activity over 23-hr for 18-week old male heterozygous (n = 10), homozygous (n = 11) and wild-type (n = 7) littermates. (E) Glucagon, glucose and lipid serum levels (as indicated) measured after overnight fasting at 24-weeks of age. WT (I/I; n = 12), heterozygous (I/F; n = 17), and homozygous (F/F; n = 15) littermates. Data are expressed as mean±SEM. *, P<0.05; **, P<0.01; ***, P<0.001 (Student's t-test) for differences between <i>Fto<sup>I367F</sup></i> and wild-type mice.</p>", "links"=>[], "tags"=>["mice", "enhanced"], "article_id"=>558185, "categories"=>["Genetics", "Biochemistry", "Virology", "Physiology"], "users"=>["Chris Church", "Sheena Lee", "Eleanor A. L. Bagg", "James S. McTaggart", "Robert Deacon", "Thomas Gerken", "Angela Lee", "Lee Moir", "Jasmin Mecinović", "Mohamed M. Quwailid", "Christopher J. Schofield", "Frances M. Ashcroft", "Roger D. Cox"], "doi"=>["https://dx.doi.org/10.1371/journal.pgen.1000599.g005"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Fto_I367F_mice_exhibit_enhanced_metabolism_/558185", "title"=>"<i>Fto</i><sup>I367F</sup> mice exhibit enhanced metabolism.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2009-08-14 02:16:25"}
  • {"files"=>["https://ndownloader.figshare.com/files/887856"], "description"=>"<p>(A–C) Urinary catecholamines norepinephrine (A), dopamine (B) and epinephrine (C) at 10 and 20 weeks (10W; 20W) in heterozygous (I/F; grey bars) and homozgygous (F/F; white bars) <i>Fto<sup>I367F</sup></i> mice compared to wild-type controls (I/I; black bars). 10 weeks: I/I, n = 13; I/F, n = 10; F/F = 10. 20 weeks: I/I, n = 14; I/F, n = 14; F/F, n = 15. (D–F) Gene expression in skeletal muscle (D), WAT (E) and BAT (F) expressed relative to GAPDH. Abbreviations not used previously: adrenergic beta-1 receptor (Adrb1), adrenergic beta-2 receptor (Adrb2), uncoupling protein 1 (Ucp1). Data are expressed as mean±SEM. *, P<0.05 (Student's t-test) for differences between <i>Fto<sup>I367F</sup></i> and wild-type mice.</p>", "links"=>[], "tags"=>["increases", "sympathetic"], "article_id"=>558300, "categories"=>["Genetics", "Biochemistry", "Virology", "Physiology"], "users"=>["Chris Church", "Sheena Lee", "Eleanor A. L. Bagg", "James S. McTaggart", "Robert Deacon", "Thomas Gerken", "Angela Lee", "Lee Moir", "Jasmin Mecinović", "Mohamed M. Quwailid", "Christopher J. Schofield", "Frances M. Ashcroft", "Roger D. Cox"], "doi"=>["https://dx.doi.org/10.1371/journal.pgen.1000599.g006"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Fto_I367F_increases_sympathetic_activity_/558300", "title"=>"<i>Fto<sup>I367F</sup></i> increases sympathetic activity.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2009-08-14 02:18:20"}
  • {"files"=>["https://ndownloader.figshare.com/files/887982"], "description"=>"<p>(A) Overlap between statistically changing genes with≥1.5 fold change in WAT, liver and skeletal muscle of homozygous <i>Fto<sup>I367F</sup></i> mice. (B) Hierarchical clustering of 121 differentially expressed immune genes and 22 fatty acid metabolism genes. Each row represents an individual animal and each column a single gene. Red-blue color code represents the relative intensity of the expression signal, with red indicating high expression and blue low expression. (C–E) Gene expression levels, relative to GAPDH, measured by q-RT-PCR for immune genes in WAT (C), and genes involved in fatty acid metabolism (D), or metabolism (E) in skeletal muscle. Black bars: wild-type mice (I/I; n = 10). Grey bars: heterozygous mice (I/F; n = 9). White bars: homozygous (F/F; n = 11). Abbreviations not used previously: <i>Acsl5</i>, acyl-CoA synthetase long-chain family member 5; <i>Acaa2</i>, acetyl-Coenzyme A acyltransferase 2. Data are expressed as mean±SEM. *, P<0.05. **, P<0.01. ***, P<0.001 (Student's t-test) for differences between <i>Fto<sup>I367F</sup></i> and wild-type mice.</p>", "links"=>[], "tags"=>["biochemistry/protein chemistry", "diabetes and endocrinology/type 2 diabetes", "genetics and genomics/animal genetics", "genetics and genomics/gene discovery", "genetics and genomics/gene function", "genetics and genomics/genetics of disease", "physiology"], "article_id"=>558418, "categories"=>["Genetics", "Biochemistry", "Virology", "Physiology"], "users"=>["Chris Church", "Sheena Lee", "Eleanor A. L. Bagg", "James S. McTaggart", "Robert Deacon", "Thomas Gerken", "Angela Lee", "Lee Moir", "Jasmin Mecinović", "Mohamed M. Quwailid", "Christopher J. Schofield", "Frances M. Ashcroft", "Roger D. Cox"], "doi"=>["https://dx.doi.org/10.1371/journal.pgen.1000599.g007"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Fto_I367F_gene_expression_analyses_/558418", "title"=>"<i>Fto<sup>I367F</sup></i> gene expression analyses.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2009-08-14 02:20:18"}

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Relative Metric

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