Long- and Short-Term Selective Forces on Malaria Parasite Genomes
Publication Date
September 09, 2010
Journal
PLOS Genetics
Authors
Sanne Nygaard, Alexander Braunstein, Gareth Malsen, Stijn Van Dongen, et al
Volume
6
Issue
9
Pages
e1001099
DOI
https://dx.plos.org/10.1371/journal.pgen.1001099
Publisher URL
http://journals.plos.org/plosgenetics/article?id=10.1371%2Fjournal.pgen.1001099
PubMed
http://www.ncbi.nlm.nih.gov/pubmed/20838588
PubMed Central
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2936524
Europe PMC
http://europepmc.org/abstract/MED/20838588
Web of Science
000282369200039
Scopus
78049449442
Mendeley
http://www.mendeley.com/research/long-shortterm-selective-forces-malaria-parasite-genomes
Events
Loading … Spinner

CiteULike | Further Information

Mendeley | Further Information

{"title"=>"Long- and short-term selective forces on malaria parasite genomes", "type"=>"journal", "authors"=>[{"first_name"=>"Sanne", "last_name"=>"Nygaard", "scopus_author_id"=>"23051569300"}, {"first_name"=>"Alexander", "last_name"=>"Braunstein", "scopus_author_id"=>"54891399800"}, {"first_name"=>"Gareth", "last_name"=>"Malsen", "scopus_author_id"=>"36610348900"}, {"first_name"=>"Stijn", "last_name"=>"Van Dongen", "scopus_author_id"=>"56243363800"}, {"first_name"=>"Paul P.", "last_name"=>"Gardner", "scopus_author_id"=>"8834594200"}, {"first_name"=>"Anders", "last_name"=>"Krogh", "scopus_author_id"=>"35373829300"}, {"first_name"=>"Thomas D.", "last_name"=>"Otto", "scopus_author_id"=>"7103379081"}, {"first_name"=>"Arnab", "last_name"=>"Pain", "scopus_author_id"=>"7004341451"}, {"first_name"=>"Matthew", "last_name"=>"Berriman", "scopus_author_id"=>"6701402385"}, {"first_name"=>"Jon", "last_name"=>"McAuliffe", "scopus_author_id"=>"7006073560"}, {"first_name"=>"Emmanouil T.", "last_name"=>"Dermitzakis", "scopus_author_id"=>"35354477100"}, {"first_name"=>"Daniel C.", "last_name"=>"Jeffares", "scopus_author_id"=>"6603226866"}], "year"=>2010, "source"=>"PLoS Genetics", "identifiers"=>{"pui"=>"359882483", "issn"=>"15537390", "isbn"=>"1553-7404 (Electronic)\\r1553-7390 (Linking)", "doi"=>"10.1371/journal.pgen.1001099", "scopus"=>"2-s2.0-78049449442", "pmid"=>"20838588", "sgr"=>"78049449442"}, "id"=>"ceab3940-d0af-3f30-a73e-64215df313a0", "abstract"=>"Plasmodium parasites, the causal agents of malaria, result in more than 1 million deaths annually. Plasmodium are unicellular eukaryotes with small ∼23 Mb genomes encoding ∼5200 protein-coding genes. The protein-coding genes comprise about half of these genomes. Although evolutionary processes have a significant impact on malaria control, the selective pressures within Plasmodium genomes are poorly understood, particularly in the non-protein-coding portion of the genome. We use evolutionary methods to describe selective processes in both the coding and non-coding regions of these genomes. Based on genome alignments of seven Plasmodium species, we show that protein-coding, intergenic and intronic regions are all subject to purifying selection and we identify 670 conserved non-genic elements. We then use genome-wide polymorphism data from P. falciparum to describe short-term selective processes in this species and identify some candidate genes for balancing (diversifying) selection. Our analyses suggest that there are many functional elements in the non-genic regions of these genomes and that adaptive evolution has occurred more frequently in the protein-coding regions of the genome.", "link"=>"http://www.mendeley.com/research/long-shortterm-selective-forces-malaria-parasite-genomes", "reader_count"=>93, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Professor > Associate Professor"=>5, "Researcher"=>34, "Student > Doctoral Student"=>4, "Student > Ph. D. Student"=>24, "Student > Postgraduate"=>2, "Student > Master"=>11, "Other"=>1, "Lecturer"=>1, "Lecturer > Senior Lecturer"=>1, "Professor"=>9}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Professor > Associate Professor"=>5, "Researcher"=>34, "Student > Doctoral Student"=>4, "Student > Ph. D. Student"=>24, "Student > Postgraduate"=>2, "Student > Master"=>11, "Other"=>1, "Lecturer"=>1, "Lecturer > Senior Lecturer"=>1, "Professor"=>9}, "reader_count_by_subject_area"=>{"Unspecified"=>4, "Environmental Science"=>1, "Biochemistry, Genetics and Molecular Biology"=>9, "Agricultural and Biological Sciences"=>67, "Medicine and Dentistry"=>5, "Business, Management and Accounting"=>1, "Psychology"=>1, "Social Sciences"=>1, "Computer Science"=>2, "Immunology and Microbiology"=>1, "Earth and Planetary Sciences"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>5}, "Social Sciences"=>{"Social Sciences"=>1}, "Psychology"=>{"Psychology"=>1}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>1}, "Earth and Planetary Sciences"=>{"Earth and Planetary Sciences"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>67}, "Computer Science"=>{"Computer Science"=>2}, "Business, Management and Accounting"=>{"Business, Management and Accounting"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>9}, "Unspecified"=>{"Unspecified"=>4}, "Environmental Science"=>{"Environmental Science"=>1}}, "reader_count_by_country"=>{"Austria"=>1, "Sweden"=>1, "Pakistan"=>1, "United States"=>4, "Japan"=>1, "Brazil"=>2, "United Kingdom"=>3, "Portugal"=>1, "Germany"=>1, "Spain"=>1}, "group_count"=>2}

Scopus | Further Information

{"@_fa"=>"true", "link"=>[{"@_fa"=>"true", "@ref"=>"self", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/78049449442"}, {"@_fa"=>"true", "@ref"=>"author-affiliation", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/78049449442?field=author,affiliation"}, {"@_fa"=>"true", "@ref"=>"scopus", "@href"=>"https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=78049449442&origin=inward"}, {"@_fa"=>"true", "@ref"=>"scopus-citedby", "@href"=>"https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=78049449442&origin=inward"}], "prism:url"=>"https://api.elsevier.com/content/abstract/scopus_id/78049449442", "dc:identifier"=>"SCOPUS_ID:78049449442", "eid"=>"2-s2.0-78049449442", "dc:title"=>"Long- and short-term selective forces on malaria parasite genomes", "dc:creator"=>"Nygaard S.", "prism:publicationName"=>"PLoS Genetics", "prism:issn"=>"15537390", "prism:eIssn"=>"15537404", "prism:volume"=>"6", "prism:issueIdentifier"=>"9", "prism:pageRange"=>nil, "prism:coverDate"=>"2010-09-01", "prism:coverDisplayDate"=>"September 2010", "prism:doi"=>"10.1371/journal.pgen.1001099", "citedby-count"=>"13", "affiliation"=>[{"@_fa"=>"true", "affilname"=>"Biotech Research & Innovation Centre", "affiliation-city"=>"Copenhagen", "affiliation-country"=>"Denmark"}, {"@_fa"=>"true", "affilname"=>"Københavns Universitet", "affiliation-city"=>"Copenhagen", "affiliation-country"=>"Denmark"}], "pubmed-id"=>"20838588", "prism:aggregationType"=>"Journal", "subtype"=>"ar", "subtypeDescription"=>"Article", "article-number"=>"e1001099", "source-id"=>"4000151808", "openaccess"=>"1", "openaccessFlag"=>true}

Facebook

  • {"url"=>"http%3A%2F%2Fjournals.plos.org%2Fplosgenetics%2Farticle%3Fid%3D10.1371%252Fjournal.pgen.1001099", "share_count"=>0, "like_count"=>0, "comment_count"=>0, "click_count"=>0, "total_count"=>0}

Counter

  • {"month"=>"9", "year"=>"2010", "pdf_views"=>"182", "xml_views"=>"9", "html_views"=>"588"}
  • {"month"=>"10", "year"=>"2010", "pdf_views"=>"152", "xml_views"=>"4", "html_views"=>"396"}
  • {"month"=>"11", "year"=>"2010", "pdf_views"=>"30", "xml_views"=>"2", "html_views"=>"113"}
  • {"month"=>"12", "year"=>"2010", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"55"}
  • {"month"=>"1", "year"=>"2011", "pdf_views"=>"13", "xml_views"=>"2", "html_views"=>"49"}
  • {"month"=>"2", "year"=>"2011", "pdf_views"=>"13", "xml_views"=>"2", "html_views"=>"61"}
  • {"month"=>"3", "year"=>"2011", "pdf_views"=>"15", "xml_views"=>"0", "html_views"=>"44"}
  • {"month"=>"4", "year"=>"2011", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"35"}
  • {"month"=>"5", "year"=>"2011", "pdf_views"=>"10", "xml_views"=>"1", "html_views"=>"30"}
  • {"month"=>"6", "year"=>"2011", "pdf_views"=>"8", "xml_views"=>"1", "html_views"=>"44"}
  • {"month"=>"7", "year"=>"2011", "pdf_views"=>"12", "xml_views"=>"1", "html_views"=>"59"}
  • {"month"=>"8", "year"=>"2011", "pdf_views"=>"5", "xml_views"=>"1", "html_views"=>"54"}
  • {"month"=>"9", "year"=>"2011", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"41"}
  • {"month"=>"10", "year"=>"2011", "pdf_views"=>"8", "xml_views"=>"1", "html_views"=>"33"}
  • {"month"=>"11", "year"=>"2011", "pdf_views"=>"9", "xml_views"=>"1", "html_views"=>"40"}
  • {"month"=>"12", "year"=>"2011", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"33"}
  • {"month"=>"1", "year"=>"2012", "pdf_views"=>"5", "xml_views"=>"1", "html_views"=>"61"}
  • {"month"=>"2", "year"=>"2012", "pdf_views"=>"9", "xml_views"=>"1", "html_views"=>"67"}
  • {"month"=>"3", "year"=>"2012", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"52"}
  • {"month"=>"4", "year"=>"2012", "pdf_views"=>"10", "xml_views"=>"2", "html_views"=>"52"}
  • {"month"=>"5", "year"=>"2012", "pdf_views"=>"9", "xml_views"=>"1", "html_views"=>"46"}
  • {"month"=>"6", "year"=>"2012", "pdf_views"=>"5", "xml_views"=>"2", "html_views"=>"25"}
  • {"month"=>"7", "year"=>"2012", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"22"}
  • {"month"=>"8", "year"=>"2012", "pdf_views"=>"8", "xml_views"=>"5", "html_views"=>"15"}
  • {"month"=>"9", "year"=>"2012", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"44"}
  • {"month"=>"10", "year"=>"2012", "pdf_views"=>"6", "xml_views"=>"1", "html_views"=>"57"}
  • {"month"=>"11", "year"=>"2012", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"52"}
  • {"month"=>"12", "year"=>"2012", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"36"}
  • {"month"=>"1", "year"=>"2013", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"49"}
  • {"month"=>"2", "year"=>"2013", "pdf_views"=>"8", "xml_views"=>"2", "html_views"=>"203"}
  • {"month"=>"3", "year"=>"2013", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"61"}
  • {"month"=>"4", "year"=>"2013", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"58"}
  • {"month"=>"5", "year"=>"2013", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"104"}
  • {"month"=>"6", "year"=>"2013", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"48"}
  • {"month"=>"7", "year"=>"2013", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"35"}
  • {"month"=>"8", "year"=>"2013", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"32"}
  • {"month"=>"9", "year"=>"2013", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"42"}
  • {"month"=>"10", "year"=>"2013", "pdf_views"=>"5", "xml_views"=>"2", "html_views"=>"50"}
  • {"month"=>"11", "year"=>"2013", "pdf_views"=>"3", "xml_views"=>"2", "html_views"=>"32"}
  • {"month"=>"12", "year"=>"2013", "pdf_views"=>"2", "xml_views"=>"1", "html_views"=>"51"}
  • {"month"=>"1", "year"=>"2014", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"26"}
  • {"month"=>"2", "year"=>"2014", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"38"}
  • {"month"=>"3", "year"=>"2014", "pdf_views"=>"4", "xml_views"=>"2", "html_views"=>"44"}
  • {"month"=>"4", "year"=>"2014", "pdf_views"=>"5", "xml_views"=>"2", "html_views"=>"59"}
  • {"month"=>"5", "year"=>"2014", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"62"}
  • {"month"=>"6", "year"=>"2014", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"44"}
  • {"month"=>"7", "year"=>"2014", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"57"}
  • {"month"=>"8", "year"=>"2014", "pdf_views"=>"1", "xml_views"=>"2", "html_views"=>"31"}
  • {"month"=>"9", "year"=>"2014", "pdf_views"=>"0", "xml_views"=>"0", "html_views"=>"49"}
  • {"month"=>"10", "year"=>"2014", "pdf_views"=>"2", "xml_views"=>"2", "html_views"=>"68"}
  • {"month"=>"11", "year"=>"2014", "pdf_views"=>"2", "xml_views"=>"1", "html_views"=>"48"}
  • {"month"=>"12", "year"=>"2014", "pdf_views"=>"7", "xml_views"=>"2", "html_views"=>"30"}
  • {"month"=>"1", "year"=>"2015", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"29"}
  • {"month"=>"2", "year"=>"2015", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"14"}
  • {"month"=>"3", "year"=>"2015", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"15"}
  • {"month"=>"4", "year"=>"2015", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"18"}
  • {"month"=>"5", "year"=>"2015", "pdf_views"=>"8", "xml_views"=>"1", "html_views"=>"26"}
  • {"month"=>"6", "year"=>"2015", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"24"}
  • {"month"=>"7", "year"=>"2015", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"10"}
  • {"month"=>"8", "year"=>"2015", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"19"}
  • {"month"=>"9", "year"=>"2015", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"17"}
  • {"month"=>"10", "year"=>"2015", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"27"}
  • {"month"=>"11", "year"=>"2015", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"16"}
  • {"month"=>"12", "year"=>"2015", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"28"}
  • {"month"=>"1", "year"=>"2016", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"26"}
  • {"month"=>"2", "year"=>"2016", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"10"}
  • {"month"=>"3", "year"=>"2016", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"18"}
  • {"month"=>"4", "year"=>"2016", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"21"}
  • {"month"=>"5", "year"=>"2016", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"17"}
  • {"month"=>"6", "year"=>"2016", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"23"}
  • {"month"=>"7", "year"=>"2016", "pdf_views"=>"0", "xml_views"=>"0", "html_views"=>"6"}
  • {"month"=>"8", "year"=>"2016", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"17"}
  • {"month"=>"9", "year"=>"2016", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"36"}
  • {"month"=>"10", "year"=>"2016", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"19"}
  • {"month"=>"11", "year"=>"2016", "pdf_views"=>"0", "xml_views"=>"0", "html_views"=>"17"}
  • {"month"=>"12", "year"=>"2016", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"6"}
  • {"month"=>"1", "year"=>"2017", "pdf_views"=>"0", "xml_views"=>"0", "html_views"=>"12"}
  • {"month"=>"2", "year"=>"2017", "pdf_views"=>"8", "xml_views"=>"1", "html_views"=>"20"}
  • {"month"=>"3", "year"=>"2017", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"19"}
  • {"month"=>"4", "year"=>"2017", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"18"}
  • {"month"=>"5", "year"=>"2017", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"19"}
  • {"month"=>"6", "year"=>"2017", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"14"}
  • {"month"=>"7", "year"=>"2017", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"17"}
  • {"month"=>"8", "year"=>"2017", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"6"}
  • {"month"=>"9", "year"=>"2017", "pdf_views"=>"2", "xml_views"=>"2", "html_views"=>"9"}
  • {"month"=>"10", "year"=>"2017", "pdf_views"=>"2", "xml_views"=>"2", "html_views"=>"18"}
  • {"month"=>"11", "year"=>"2017", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"19"}
  • {"month"=>"12", "year"=>"2017", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"5"}
  • {"month"=>"1", "year"=>"2018", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"8"}
  • {"month"=>"2", "year"=>"2018", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"6"}
  • {"month"=>"3", "year"=>"2018", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"2"}
  • {"month"=>"4", "year"=>"2018", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"7"}
  • {"month"=>"5", "year"=>"2018", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"6"}
  • {"month"=>"6", "year"=>"2018", "pdf_views"=>"3", "xml_views"=>"1", "html_views"=>"3"}
  • {"month"=>"7", "year"=>"2018", "pdf_views"=>"1", "xml_views"=>"3", "html_views"=>"2"}
  • {"month"=>"8", "year"=>"2018", "pdf_views"=>"0", "xml_views"=>"1", "html_views"=>"2"}
  • {"month"=>"9", "year"=>"2018", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"6"}
  • {"month"=>"10", "year"=>"2018", "pdf_views"=>"6", "xml_views"=>"1", "html_views"=>"6"}
  • {"month"=>"11", "year"=>"2018", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"7"}
  • {"month"=>"12", "year"=>"2018", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"9"}
  • {"month"=>"1", "year"=>"2019", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"7"}
  • {"month"=>"2", "year"=>"2019", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"17"}
  • {"month"=>"3", "year"=>"2019", "pdf_views"=>"5", "xml_views"=>"1", "html_views"=>"9"}
  • {"month"=>"4", "year"=>"2019", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"4"}
  • {"month"=>"5", "year"=>"2019", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"4"}
  • {"month"=>"6", "year"=>"2019", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"6"}
  • {"month"=>"7", "year"=>"2019", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"4"}
  • {"month"=>"8", "year"=>"2019", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"4"}
  • {"month"=>"9", "year"=>"2019", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"0"}

Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/832184"], "description"=>"<p>*Also predicted to be highly polymorphic genes that are potential immune or drug targets in Mu <i>et al.</i><a href=\"http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1001099#pgen.1001099-Mu1\" target=\"_blank\">[29]</a>.</p>", "links"=>[], "tags"=>["genes", "balancing"], "article_id"=>502536, "categories"=>["Genetics", "Evolutionary Biology", "Infectious Diseases"], "users"=>["Sanne Nygaard", "Alexander Braunstein", "Gareth Malsen", "Stijn van Dongen", "Paul P. Gardner", "Anders Krogh", "Thomas D. Otto", "Arnab Pain", "Matthew Berriman", "Jon McAuliffe", "Emmanouil T. Dermitzakis", "Daniel C. Jeffares"], "doi"=>"https://dx.doi.org/10.1371/journal.pgen.1001099.t002", "stats"=>{"downloads"=>0, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Candidate_genes_for_balancing_selection_in_P_falciparum_/502536", "title"=>"Candidate genes for balancing selection in <i>P. falciparum</i>.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2010-09-09 00:42:16"}
  • {"files"=>["https://ndownloader.figshare.com/files/832234"], "description"=>"<p>The number of conserved elements ≥25 nt that overlap various annotations in three Plasmodium species (one from each clade), or combinations of species.</p>", "links"=>[], "tags"=>["evolutionary biology/genomics", "genetics and genomics/comparative genomics", "genetics and genomics/population genetics", "Infectious diseases"], "article_id"=>502595, "categories"=>["Genetics", "Evolutionary Biology", "Infectious Diseases"], "users"=>["Sanne Nygaard", "Alexander Braunstein", "Gareth Malsen", "Stijn van Dongen", "Paul P. Gardner", "Anders Krogh", "Thomas D. Otto", "Arnab Pain", "Matthew Berriman", "Jon McAuliffe", "Emmanouil T. Dermitzakis", "Daniel C. Jeffares"], "doi"=>"https://dx.doi.org/10.1371/journal.pgen.1001099.t001", "stats"=>{"downloads"=>0, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Conserved_Element_CE_annotations_/502595", "title"=>"Conserved Element (CE) annotations.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2010-09-09 00:43:15"}
  • {"files"=>["https://ndownloader.figshare.com/files/831388"], "description"=>"<p>A) Summary of genome data in the context of Plasmodium phylogeny. Branch lengths are generated using the HKY85 model of full alignment, an approximate scale bar of 0.1 substitutions/site is shown. The three main clades are labelled according the mammalian hosts; R (rodent-infecting), P (primate-infecting, human <i>P. vivax</i>, human/macaque <i>P. knowlesi</i>), A (ape-infecting, human <i>P. falciparum</i>, chimpanzee <i>P. reichenowi</i>). * The <i>P. reichenowi</i> genome was generated from read alignments to <i>P. falciparum</i>, we assume a genome of ∼23 Mb. B) Alignment quality in a selected alignment block. At the top of the figure, the yellow boxes show conserved elements (CEs) ≥25 nt predicted by GERP, grey boxes and lines show annotated exons and introns for <i>P. falciparum</i>, <i>P. knowlesi</i> and <i>P. yoelii</i> (upper, middle and lower respectively). Below, the grey peaks shows the GERP score over a sliding window of 25 nt (higher GERP scores indicate stronger evidence for conservation). The red and blue lines indicate the percentage of the window that contains aligned nucleotides (<i>i.e.</i>: not gaps) and the percentage identity of the alignment, both over a 1000 nt window.</p>", "links"=>[], "tags"=>["alignment", "plasmodium"], "article_id"=>501742, "categories"=>["Genetics", "Evolutionary Biology", "Infectious Diseases"], "users"=>["Sanne Nygaard", "Alexander Braunstein", "Gareth Malsen", "Stijn van Dongen", "Paul P. Gardner", "Anders Krogh", "Thomas D. Otto", "Arnab Pain", "Matthew Berriman", "Jon McAuliffe", "Emmanouil T. Dermitzakis", "Daniel C. Jeffares"], "doi"=>"https://dx.doi.org/10.1371/journal.pgen.1001099.g001", "stats"=>{"downloads"=>0, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Genome_wide_alignment_of_Plasmodium_species_/501742", "title"=>"Genome-wide alignment of Plasmodium species.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2010-09-09 00:29:02"}
  • {"files"=>["https://ndownloader.figshare.com/files/831994"], "description"=>"<p>A) The total counts of all pairwise comparisons within conserved elements plotted against the distance between substitutions. A bias towards multiple-of-three spaced substitutions (3, 6, 9 <i>etc.</i>) is expected in protein-coding elements. Above, counts in 670 exonic CEs (black circles) and these exonic CEs after shuffling alignments (grey line). There is an excess of substitutions separated by a multiples of three nucleotides in the exonic elements compared to the shuffled data. Below, counts in the 670 non-exonic CEs (red circles) and these non-exonic CEs after shuffling alignments (pink line). There is a small excess of multiple-of-three-spaced substitutions, observable at x-axis positions 15, 18 and 21. B) The distribution of the proportion of multiple-of-three-spaced substitutions scores (PMOT) for the exonic CE control set (black lines) and non-exonic CEs (red line). The shuffled exon set (grey line), and shuffled non-exon set (pink line) are also shown. The non-exon set closely resembles the shuffled non-exon set. The vertical black line shows the 5<sup>th</sup> percentiles of exon PMOT values, elements with PMOT scores less than this are unlikely to be protein-coding. The vertical pink line shows the 95<sup>th</sup> percentile of shuffled non-exon PMOT values, elements with PMOT values above this are very likely to be exons.</p>", "links"=>[], "tags"=>["constrained"], "article_id"=>502361, "categories"=>["Genetics", "Evolutionary Biology", "Infectious Diseases"], "users"=>["Sanne Nygaard", "Alexander Braunstein", "Gareth Malsen", "Stijn van Dongen", "Paul P. Gardner", "Anders Krogh", "Thomas D. Otto", "Arnab Pain", "Matthew Berriman", "Jon McAuliffe", "Emmanouil T. Dermitzakis", "Daniel C. Jeffares"], "doi"=>"https://dx.doi.org/10.1371/journal.pgen.1001099.g004", "stats"=>{"downloads"=>0, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Protein_coding_potential_in_Constrained_Elements_/502361", "title"=>"Protein-coding potential in Constrained Elements.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2010-09-09 00:39:21"}
  • {"files"=>["https://ndownloader.figshare.com/files/831536"], "description"=>"<p>A) Selective constraint estimates relative to FFD sites, calculated for the whole alignment (Full aln.), exonic regions, intergenic regions (IGR), and intronic regions using six different models (see text and <a href=\"http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1001099#s4\" target=\"_blank\">Materials and Methods</a> for details). Error bars show the minimum and maximum values obtained by bootstrapping, and are enlarged five times to be visible in all cases. Exon regions are the most highly constrained (0.70–0.72), but intergenic regions (0.50–0.51) and introns (0.40–0.41), also show considerable constraint. The genome constraint is 0.59–0.60. B) Selective constraint estimates near intron (upper panels) and intergenic (lower panels) boundaries. Intron (donor) shows the 5′ end of an intron, Intron (acceptor) the 3′ end. Intergenic (promoter and terminator) shows the regions upstream and downstream of protein-coding genes. Annotations of a particular feature (intron, intergenic region) do not always coincide exactly between species, here we show the shortest consensus. Using the longest consensus instead did not affect results significantly (see <a href=\"http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1001099#pgen.1001099.s005\" target=\"_blank\">Figure S5</a>. for a comparison). C) The number of <i>P. falciparum</i> nucleotides that are ‘well aligned’ (aligned in ≥four species) and the number that are constrained for the whole genome, exons, intergenic regions and introns.</p>", "links"=>[], "tags"=>["plasmodium"], "article_id"=>501898, "categories"=>["Genetics", "Evolutionary Biology", "Infectious Diseases"], "users"=>["Sanne Nygaard", "Alexander Braunstein", "Gareth Malsen", "Stijn van Dongen", "Paul P. Gardner", "Anders Krogh", "Thomas D. Otto", "Arnab Pain", "Matthew Berriman", "Jon McAuliffe", "Emmanouil T. Dermitzakis", "Daniel C. Jeffares"], "doi"=>"https://dx.doi.org/10.1371/journal.pgen.1001099.g002", "stats"=>{"downloads"=>0, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Selective_constraint_in_Plasmodium_genomes_/501898", "title"=>"Selective constraint in Plasmodium genomes.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2010-09-09 00:31:38"}
  • {"files"=>["https://ndownloader.figshare.com/files/832125"], "description"=>"<p>Scatter plot of the McDonald-Kreitman test neutrality index (NI) and Tajima's D. Grey lines show the 80<sup>th</sup> percentiles of NI and D. Filled circles show the 19 genes that have both NI and D values greater the 80<sup>th</sup> percentiles. The square box indicates <i>AMA1</i> (PF11_0344) and the triangle indicates <i>RhopH3</i> (PFI0265c).</p>", "links"=>[], "tags"=>["mk", "ni"], "article_id"=>502487, "categories"=>["Genetics", "Evolutionary Biology", "Infectious Diseases"], "users"=>["Sanne Nygaard", "Alexander Braunstein", "Gareth Malsen", "Stijn van Dongen", "Paul P. Gardner", "Anders Krogh", "Thomas D. Otto", "Arnab Pain", "Matthew Berriman", "Jon McAuliffe", "Emmanouil T. Dermitzakis", "Daniel C. Jeffares"], "doi"=>"https://dx.doi.org/10.1371/journal.pgen.1001099.g005", "stats"=>{"downloads"=>0, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Tajima_s_D_and_MK_test_NI_values_for_P_falciparum_genes_/502487", "title"=>"Tajima's D and MK test NI values for <i>P. falciparum</i> genes.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2010-09-09 00:41:27"}
  • {"files"=>["https://ndownloader.figshare.com/files/413813", "https://ndownloader.figshare.com/files/413849", "https://ndownloader.figshare.com/files/413877", "https://ndownloader.figshare.com/files/413917", "https://ndownloader.figshare.com/files/413958", "https://ndownloader.figshare.com/files/413990", "https://ndownloader.figshare.com/files/414056", "https://ndownloader.figshare.com/files/414076", "https://ndownloader.figshare.com/files/414094", "https://ndownloader.figshare.com/files/414121", "https://ndownloader.figshare.com/files/414168", "https://ndownloader.figshare.com/files/414196", "https://ndownloader.figshare.com/files/414225", "https://ndownloader.figshare.com/files/414245"], "description"=>"<div><p>Plasmodium parasites, the causal agents of malaria, result in more than 1 million deaths annually. Plasmodium are unicellular eukaryotes with small ∼23 Mb genomes encoding ∼5200 protein-coding genes. The protein-coding genes comprise about half of these genomes. Although evolutionary processes have a significant impact on malaria control, the selective pressures within Plasmodium genomes are poorly understood, particularly in the non-protein-coding portion of the genome. We use evolutionary methods to describe selective processes in both the coding and non-coding regions of these genomes. Based on genome alignments of seven Plasmodium species, we show that protein-coding, intergenic and intronic regions are all subject to purifying selection and we identify 670 conserved non-genic elements. We then use genome-wide polymorphism data from <em>P. falciparum</em> to describe short-term selective processes in this species and identify some candidate genes for balancing (diversifying) selection. Our analyses suggest that there are many functional elements in the non-genic regions of these genomes and that adaptive evolution has occurred more frequently in the protein-coding regions of the genome.</p></div>", "links"=>[], "tags"=>["long-", "selective", "forces", "malaria", "parasite", "genomes"], "article_id"=>141732, "categories"=>["Cancer", "Genetics", "Evolutionary Biology"], "users"=>["Sanne Nygaard", "Alexander Braunstein", "Gareth Malsen", "Stijn van Dongen", "Paul P. Gardner", "Anders Krogh", "Thomas D. Otto", "Arnab Pain", "Matthew Berriman", "Jon McAuliffe", "Emmanouil T. Dermitzakis", "Daniel C. Jeffares"], "doi"=>["https://dx.doi.org/10.1371/journal.pgen.1001099.s001", "https://dx.doi.org/10.1371/journal.pgen.1001099.s002", "https://dx.doi.org/10.1371/journal.pgen.1001099.s003", "https://dx.doi.org/10.1371/journal.pgen.1001099.s004", "https://dx.doi.org/10.1371/journal.pgen.1001099.s005", "https://dx.doi.org/10.1371/journal.pgen.1001099.s006", "https://dx.doi.org/10.1371/journal.pgen.1001099.s007", "https://dx.doi.org/10.1371/journal.pgen.1001099.s008", "https://dx.doi.org/10.1371/journal.pgen.1001099.s009", "https://dx.doi.org/10.1371/journal.pgen.1001099.s010", "https://dx.doi.org/10.1371/journal.pgen.1001099.s011", "https://dx.doi.org/10.1371/journal.pgen.1001099.s012", "https://dx.doi.org/10.1371/journal.pgen.1001099.s013", "https://dx.doi.org/10.1371/journal.pgen.1001099.s014"], "stats"=>{"downloads"=>0, "page_views"=>26, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Long_and_Short_Term_Selective_Forces_on_Malaria_Parasite_Genomes/141732", "title"=>"Long- and Short-Term Selective Forces on Malaria Parasite Genomes", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2010-09-09 00:28:52"}
  • {"files"=>["https://ndownloader.figshare.com/files/831755"], "description"=>"<p>The distribution of conserved elements (CEs) across the lengths of promoter regions (A), terminator regions (B), introns (C) and exons (D). Positions are the midpoint of the CE with respect to the proportion of the length of the annotated exon, promoter, <i>etc.</i>, <i>e.g.</i>: a CE at 0.1 is centred at 1/10<sup>th</sup> the length of the exon. All positions are with respect to the <i>P. falciparum</i> annotation. Since UTRs are not well annotated in <i>P. falciparum</i>, we divide all intergenic regions (IGR) in half, and refer to any IGR half that is closer to a gene start codon as a promoter region, and any IGR half that is closer to a gene stop codon as a terminator region. Exon CEs are plotted in quartiles because long exon CEs frequently cover most the exon (median exon length is 192 nt), resulting in long exon CE midpoints being preferentially located in the middle of exons.</p>", "links"=>[], "tags"=>["evolutionary biology/genomics", "genetics and genomics/comparative genomics", "genetics and genomics/population genetics", "Infectious diseases"], "article_id"=>502111, "categories"=>["Genetics", "Evolutionary Biology", "Infectious Diseases"], "users"=>["Sanne Nygaard", "Alexander Braunstein", "Gareth Malsen", "Stijn van Dongen", "Paul P. Gardner", "Anders Krogh", "Thomas D. Otto", "Arnab Pain", "Matthew Berriman", "Jon McAuliffe", "Emmanouil T. Dermitzakis", "Daniel C. Jeffares"], "doi"=>"https://dx.doi.org/10.1371/journal.pgen.1001099.g003", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Constrained_Element_distribution_/502111", "title"=>"Constrained Element distribution.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2010-09-09 00:35:11"}

PMC Usage Stats | Further Information

  • {"unique-ip"=>"17", "full-text"=>"16", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"1", "year"=>"2015", "month"=>"11"}
  • {"unique-ip"=>"3", "full-text"=>"3", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"12"}
  • {"unique-ip"=>"5", "full-text"=>"4", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"1"}
  • {"unique-ip"=>"6", "full-text"=>"5", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"2"}
  • {"unique-ip"=>"8", "full-text"=>"7", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"3"}
  • {"unique-ip"=>"12", "full-text"=>"12", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2016", "month"=>"4"}
  • {"unique-ip"=>"6", "full-text"=>"5", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"5"}
  • {"unique-ip"=>"7", "full-text"=>"5", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"6"}
  • {"unique-ip"=>"3", "full-text"=>"1", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2016", "month"=>"7"}
  • {"unique-ip"=>"1", "full-text"=>"2", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"8"}
  • {"unique-ip"=>"5", "full-text"=>"5", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"9"}
  • {"unique-ip"=>"5", "full-text"=>"4", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"10"}
  • {"unique-ip"=>"5", "full-text"=>"5", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"11"}
  • {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"12"}
  • {"unique-ip"=>"8", "full-text"=>"3", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"1"}
  • {"unique-ip"=>"8", "full-text"=>"7", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"2"}
  • {"unique-ip"=>"5", "full-text"=>"3", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2017", "month"=>"4"}
  • {"unique-ip"=>"1", "full-text"=>"1", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"5"}
  • {"unique-ip"=>"2", "full-text"=>"3", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"6"}
  • {"unique-ip"=>"1", "full-text"=>"1", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"7"}
  • {"unique-ip"=>"4", "full-text"=>"3", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"8"}
  • {"unique-ip"=>"2", "full-text"=>"2", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"9"}
  • {"unique-ip"=>"6", "full-text"=>"4", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"10"}
  • {"unique-ip"=>"1", "full-text"=>"1", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"11"}
  • {"unique-ip"=>"1", "full-text"=>"1", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"12"}
  • {"unique-ip"=>"3", "full-text"=>"3", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"1"}
  • {"unique-ip"=>"2", "full-text"=>"2", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"3"}
  • {"unique-ip"=>"11", "full-text"=>"10", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"6", "cited-by"=>"0", "year"=>"2019", "month"=>"1"}
  • {"unique-ip"=>"4", "full-text"=>"5", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"4"}
  • {"unique-ip"=>"5", "full-text"=>"6", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"5"}
  • {"unique-ip"=>"7", "full-text"=>"6", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"6"}
  • {"unique-ip"=>"11", "full-text"=>"7", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"4", "cited-by"=>"0", "year"=>"2018", "month"=>"7"}
  • {"unique-ip"=>"2", "full-text"=>"2", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"8"}
  • {"unique-ip"=>"8", "full-text"=>"12", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"10"}
  • {"unique-ip"=>"5", "full-text"=>"12", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"9"}
  • {"unique-ip"=>"6", "full-text"=>"5", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"14", "cited-by"=>"0", "year"=>"2018", "month"=>"11"}
  • {"unique-ip"=>"10", "full-text"=>"8", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"13", "cited-by"=>"0", "year"=>"2018", "month"=>"12"}
  • {"unique-ip"=>"8", "full-text"=>"9", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"2"}
  • {"unique-ip"=>"3", "full-text"=>"6", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"3"}
  • {"unique-ip"=>"6", "full-text"=>"7", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"4"}
  • {"unique-ip"=>"10", "full-text"=>"11", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"5"}
  • {"unique-ip"=>"6", "full-text"=>"8", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"8"}

Relative Metric

{"start_date"=>"2010-01-01T00:00:00Z", "end_date"=>"2010-12-31T00:00:00Z", "subject_areas"=>[{"subject_area"=>"/Biology and life sciences/Biochemistry", "average_usage"=>[283, 565, 720, 852, 970, 1070, 1168, 1258, 1336, 1411, 1487, 1571, 1640, 1709, 1776, 1843, 1906, 1969, 2031, 2086, 2152, 2221, 2286, 2361, 2419, 2480, 2543, 2598, 2665, 2731, 2802, 2868, 2932, 2996, 3053, 3114, 3169, 3232, 3289, 3355, 3413, 3473, 3530, 3595, 3648, 3711, 3764, 3810, 3863]}, {"subject_area"=>"/Biology and life sciences/Computational biology", "average_usage"=>[334, 662, 847, 1004, 1136, 1245, 1346, 1439, 1513, 1595, 1657, 1726, 1787, 1853, 1905, 1972, 2049, 2112, 2182, 2254, 2335, 2411, 2473, 2537, 2587, 2662, 2729, 2786, 2849, 2932, 2997, 3055, 3122, 3190, 3270, 3331, 3398, 3472, 3534, 3611, 3684, 3766, 3814, 3865, 3909, 3956, 4011, 4073, 4112]}, {"subject_area"=>"/Biology and life sciences/Molecular biology", "average_usage"=>[286, 573, 735, 872, 989, 1096, 1185, 1277, 1365, 1449, 1520, 1597, 1668, 1729, 1799, 1852, 1917, 1984, 2054, 2108, 2169, 2234, 2303, 2374, 2436, 2501, 2560, 2620, 2683, 2742, 2830, 2909, 2981, 3032, 3089, 3148, 3210, 3266, 3323, 3379, 3448, 3512, 3576, 3635, 3693, 3747, 3827, 3876, 3938]}, {"subject_area"=>"/Biology and life sciences/Parasitology", "average_usage"=>[277, 573, 714, 825, 931, 1032, 1126, 1207, 1278, 1351, 1422, 1495, 1558, 1626, 1696, 1747, 1811, 1888, 1954, 2005, 2095, 2149, 2214, 2277, 2318, 2389, 2436, 2493, 2567, 2666, 2727, 2784, 2871, 2936, 2984, 3058, 3116, 3178, 3223, 3295, 3360, 3423, 3504, 3579, 3645, 3716, 3757, 3826, 3873]}]}
Loading … Spinner
There are currently no alerts