An Immune Response Network Associated with Blood Lipid Levels
Publication Date
September 09, 2010
Journal
PLOS Genetics
Authors
Michael Inouye, Kaisa Silander, Eija Hamalainen, Veikko Salomaa, et al
Volume
6
Issue
9
Pages
e1001113
DOI
https://dx.plos.org/10.1371/journal.pgen.1001113
Publisher URL
http://journals.plos.org/plosgenetics/article?id=10.1371%2Fjournal.pgen.1001113
PubMed
http://www.ncbi.nlm.nih.gov/pubmed/20844574
PubMed Central
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2936545
Europe PMC
http://europepmc.org/abstract/MED/20844574
Web of Science
000282369200051
Scopus
78049420683
Mendeley
http://www.mendeley.com/research/immune-response-network-associated-blood-lipid-levels
Events
Loading … Spinner

CiteULike | Further Information

Mendeley | Further Information

{"title"=>"An immune response network associated with blood lipid levels", "type"=>"journal", "authors"=>[{"first_name"=>"Michael", "last_name"=>"Inouye", "scopus_author_id"=>"22953271700"}, {"first_name"=>"Kaisa", "last_name"=>"Silander", "scopus_author_id"=>"6603017528"}, {"first_name"=>"Eija", "last_name"=>"Hamalainen", "scopus_author_id"=>"35310343300"}, {"first_name"=>"Veikko", "last_name"=>"Salomaa", "scopus_author_id"=>"7004714461"}, {"first_name"=>"Kennet", "last_name"=>"Harald", "scopus_author_id"=>"13003074900"}, {"first_name"=>"Pekka", "last_name"=>"Jousilahti", "scopus_author_id"=>"7005647985"}, {"first_name"=>"Satu", "last_name"=>"Männistö", "scopus_author_id"=>"6701509717"}, {"first_name"=>"Johan G.", "last_name"=>"Eriksson", "scopus_author_id"=>"7202626958"}, {"first_name"=>"Janna", "last_name"=>"Saarela", "scopus_author_id"=>"7004368900"}, {"first_name"=>"Samuli", "last_name"=>"Ripatti", "scopus_author_id"=>"6603009457"}, {"first_name"=>"Markus", "last_name"=>"Perola", "scopus_author_id"=>"7003719630"}, {"first_name"=>"Gert Jan B.", "last_name"=>"van Ommen", "scopus_author_id"=>"35411955100"}, {"first_name"=>"Marja Riitta", "last_name"=>"Taskinen", "scopus_author_id"=>"57193256111"}, {"first_name"=>"Aarno", "last_name"=>"Palotie", "scopus_author_id"=>"7005614368"}, {"first_name"=>"Emmanouil T.", "last_name"=>"Dermitzakis", "scopus_author_id"=>"35354477100"}, {"first_name"=>"Leena", "last_name"=>"Peltonen", "scopus_author_id"=>"36051313500"}], "year"=>2010, "source"=>"PLoS Genetics", "identifiers"=>{"issn"=>"15537390", "scopus"=>"2-s2.0-78049420683", "sgr"=>"78049420683", "pui"=>"359882495", "isbn"=>"1553-7404 (Electronic)\\r1553-7390 (Linking)", "pmid"=>"20844574", "doi"=>"10.1371/journal.pgen.1001113"}, "id"=>"8bbe8c84-1abc-3b76-9a02-f87ce0c0fbfb", "abstract"=>"While recent scans for genetic variation associated with human disease have been immensely successful in uncovering large numbers of loci, far fewer studies have focused on the underlying pathways of disease pathogenesis. Many loci which are associated with disease and complex phenotypes map to non-coding, regulatory regions of the genome, indicating that modulation of gene transcription plays a key role. Thus, this study generated genome-wide profiles of both genetic and transcriptional variation from the total blood extracts of over 500 randomly-selected, unrelated individuals. Using measurements of blood lipids, key players in the progression of atherosclerosis, three levels of biological information are integrated in order to investigate the interactions between circulating leukocytes and proximal lipid compounds. Pair-wise correlations between gene expression and lipid concentration indicate a prominent role for basophil granulocytes and mast cells, cell types central to powerful allergic and inflammatory responses. Network analysis of gene co-expression showed that the top associations function as part of a single, previously unknown gene module, the Lipid Leukocyte (LL) module. This module replicated in T cells from an independent cohort while also displaying potential tissue specificity. Further, genetic variation driving LL module expression included the single nucleotide polymorphism (SNP) most strongly associated with serum immunoglobulin E (IgE) levels, a key antibody in allergy. Structural Equation Modeling (SEM) indicated that LL module is at least partially reactive to blood lipid levels. Taken together, this study uncovers a gene network linking blood lipids and circulating cell types and offers insight into the hypothesis that the inflammatory response plays a prominent role in metabolism and the potential control of atherogenesis.", "link"=>"http://www.mendeley.com/research/immune-response-network-associated-blood-lipid-levels", "reader_count"=>100, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Professor > Associate Professor"=>10, "Researcher"=>39, "Student > Doctoral Student"=>3, "Student > Ph. D. Student"=>28, "Student > Postgraduate"=>1, "Student > Master"=>10, "Other"=>3, "Student > Bachelor"=>2, "Professor"=>3}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Professor > Associate Professor"=>10, "Researcher"=>39, "Student > Doctoral Student"=>3, "Student > Ph. D. Student"=>28, "Student > Postgraduate"=>1, "Student > Master"=>10, "Other"=>3, "Student > Bachelor"=>2, "Professor"=>3}, "reader_count_by_subject_area"=>{"Unspecified"=>4, "Engineering"=>1, "Biochemistry, Genetics and Molecular Biology"=>7, "Mathematics"=>4, "Agricultural and Biological Sciences"=>55, "Medicine and Dentistry"=>18, "Pharmacology, Toxicology and Pharmaceutical Science"=>1, "Business, Management and Accounting"=>1, "Physics and Astronomy"=>2, "Social Sciences"=>1, "Computer Science"=>5, "Immunology and Microbiology"=>1}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>1}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>18}, "Social Sciences"=>{"Social Sciences"=>1}, "Physics and Astronomy"=>{"Physics and Astronomy"=>2}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>55}, "Computer Science"=>{"Computer Science"=>5}, "Business, Management and Accounting"=>{"Business, Management and Accounting"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>7}, "Mathematics"=>{"Mathematics"=>4}, "Unspecified"=>{"Unspecified"=>4}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>1}}, "reader_count_by_country"=>{"Netherlands"=>1, "Czech Republic"=>1, "Norway"=>1, "United States"=>7, "Ireland"=>2, "Japan"=>1, "Finland"=>1, "Brazil"=>1, "United Kingdom"=>2, "Italy"=>2, "France"=>1}, "group_count"=>5}

CrossRef

Scopus | Further Information

{"@_fa"=>"true", "link"=>[{"@_fa"=>"true", "@ref"=>"self", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/78049420683"}, {"@_fa"=>"true", "@ref"=>"author-affiliation", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/78049420683?field=author,affiliation"}, {"@_fa"=>"true", "@ref"=>"scopus", "@href"=>"https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=78049420683&origin=inward"}, {"@_fa"=>"true", "@ref"=>"scopus-citedby", "@href"=>"https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=78049420683&origin=inward"}], "prism:url"=>"https://api.elsevier.com/content/abstract/scopus_id/78049420683", "dc:identifier"=>"SCOPUS_ID:78049420683", "eid"=>"2-s2.0-78049420683", "dc:title"=>"An immune response network associated with blood lipid levels", "dc:creator"=>"Inouye M.", "prism:publicationName"=>"PLoS Genetics", "prism:issn"=>"15537390", "prism:eIssn"=>"15537404", "prism:volume"=>"6", "prism:issueIdentifier"=>"9", "prism:pageRange"=>nil, "prism:coverDate"=>"2010-09-01", "prism:coverDisplayDate"=>"September 2010", "prism:doi"=>"10.1371/journal.pgen.1001113", "citedby-count"=>"78", "affiliation"=>[{"@_fa"=>"true", "affilname"=>"Walter and Eliza Hall Institute of Medical Research", "affiliation-city"=>"Melbourne", "affiliation-country"=>"Australia"}, {"@_fa"=>"true", "affilname"=>"Leiden University Medical Center - LUMC", "affiliation-city"=>"Leiden", "affiliation-country"=>"Netherlands"}, {"@_fa"=>"true", "affilname"=>"Wellcome Sanger Institute", "affiliation-city"=>"Hinxton", "affiliation-country"=>"United Kingdom"}], "pubmed-id"=>"20844574", "prism:aggregationType"=>"Journal", "subtype"=>"ar", "subtypeDescription"=>"Article", "article-number"=>"e1001113", "source-id"=>"4000151808", "openaccess"=>"1", "openaccessFlag"=>true}

Facebook

  • {"url"=>"http%3A%2F%2Fjournals.plos.org%2Fplosgenetics%2Farticle%3Fid%3D10.1371%252Fjournal.pgen.1001113", "share_count"=>0, "like_count"=>0, "comment_count"=>0, "click_count"=>0, "total_count"=>0}

Counter

  • {"month"=>"9", "year"=>"2010", "pdf_views"=>"254", "xml_views"=>"12", "html_views"=>"772"}
  • {"month"=>"10", "year"=>"2010", "pdf_views"=>"155", "xml_views"=>"3", "html_views"=>"373"}
  • {"month"=>"11", "year"=>"2010", "pdf_views"=>"44", "xml_views"=>"1", "html_views"=>"119"}
  • {"month"=>"12", "year"=>"2010", "pdf_views"=>"28", "xml_views"=>"0", "html_views"=>"83"}
  • {"month"=>"1", "year"=>"2011", "pdf_views"=>"55", "xml_views"=>"2", "html_views"=>"161"}
  • {"month"=>"2", "year"=>"2011", "pdf_views"=>"35", "xml_views"=>"2", "html_views"=>"87"}
  • {"month"=>"3", "year"=>"2011", "pdf_views"=>"42", "xml_views"=>"0", "html_views"=>"88"}
  • {"month"=>"4", "year"=>"2011", "pdf_views"=>"36", "xml_views"=>"0", "html_views"=>"76"}
  • {"month"=>"5", "year"=>"2011", "pdf_views"=>"15", "xml_views"=>"0", "html_views"=>"63"}
  • {"month"=>"6", "year"=>"2011", "pdf_views"=>"18", "xml_views"=>"0", "html_views"=>"36"}
  • {"month"=>"7", "year"=>"2011", "pdf_views"=>"19", "xml_views"=>"0", "html_views"=>"66"}
  • {"month"=>"8", "year"=>"2011", "pdf_views"=>"10", "xml_views"=>"3", "html_views"=>"72"}
  • {"month"=>"9", "year"=>"2011", "pdf_views"=>"18", "xml_views"=>"0", "html_views"=>"67"}
  • {"month"=>"10", "year"=>"2011", "pdf_views"=>"23", "xml_views"=>"0", "html_views"=>"62"}
  • {"month"=>"11", "year"=>"2011", "pdf_views"=>"23", "xml_views"=>"1", "html_views"=>"65"}
  • {"month"=>"12", "year"=>"2011", "pdf_views"=>"14", "xml_views"=>"0", "html_views"=>"62"}
  • {"month"=>"1", "year"=>"2012", "pdf_views"=>"17", "xml_views"=>"0", "html_views"=>"89"}
  • {"month"=>"2", "year"=>"2012", "pdf_views"=>"16", "xml_views"=>"0", "html_views"=>"78"}
  • {"month"=>"3", "year"=>"2012", "pdf_views"=>"19", "xml_views"=>"0", "html_views"=>"83"}
  • {"month"=>"4", "year"=>"2012", "pdf_views"=>"15", "xml_views"=>"1", "html_views"=>"97"}
  • {"month"=>"5", "year"=>"2012", "pdf_views"=>"28", "xml_views"=>"1", "html_views"=>"95"}
  • {"month"=>"6", "year"=>"2012", "pdf_views"=>"13", "xml_views"=>"2", "html_views"=>"66"}
  • {"month"=>"7", "year"=>"2012", "pdf_views"=>"15", "xml_views"=>"0", "html_views"=>"67"}
  • {"month"=>"8", "year"=>"2012", "pdf_views"=>"16", "xml_views"=>"6", "html_views"=>"62"}
  • {"month"=>"9", "year"=>"2012", "pdf_views"=>"16", "xml_views"=>"0", "html_views"=>"92"}
  • {"month"=>"10", "year"=>"2012", "pdf_views"=>"20", "xml_views"=>"2", "html_views"=>"81"}
  • {"month"=>"11", "year"=>"2012", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"88"}
  • {"month"=>"12", "year"=>"2012", "pdf_views"=>"19", "xml_views"=>"0", "html_views"=>"76"}
  • {"month"=>"1", "year"=>"2013", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"61"}
  • {"month"=>"2", "year"=>"2013", "pdf_views"=>"11", "xml_views"=>"2", "html_views"=>"169"}
  • {"month"=>"3", "year"=>"2013", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"54"}
  • {"month"=>"4", "year"=>"2013", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"60"}
  • {"month"=>"5", "year"=>"2013", "pdf_views"=>"19", "xml_views"=>"0", "html_views"=>"63"}
  • {"month"=>"6", "year"=>"2013", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"47"}
  • {"month"=>"7", "year"=>"2013", "pdf_views"=>"8", "xml_views"=>"2", "html_views"=>"46"}
  • {"month"=>"8", "year"=>"2013", "pdf_views"=>"14", "xml_views"=>"2", "html_views"=>"58"}
  • {"month"=>"9", "year"=>"2013", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"69"}
  • {"month"=>"10", "year"=>"2013", "pdf_views"=>"14", "xml_views"=>"6", "html_views"=>"96"}
  • {"month"=>"11", "year"=>"2013", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"72"}
  • {"month"=>"12", "year"=>"2013", "pdf_views"=>"12", "xml_views"=>"5", "html_views"=>"127"}
  • {"month"=>"1", "year"=>"2014", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"54"}
  • {"month"=>"2", "year"=>"2014", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"114"}
  • {"month"=>"3", "year"=>"2014", "pdf_views"=>"10", "xml_views"=>"2", "html_views"=>"120"}
  • {"month"=>"4", "year"=>"2014", "pdf_views"=>"9", "xml_views"=>"2", "html_views"=>"88"}
  • {"month"=>"5", "year"=>"2014", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"105"}
  • {"month"=>"6", "year"=>"2014", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"124"}
  • {"month"=>"7", "year"=>"2014", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"61"}
  • {"month"=>"8", "year"=>"2014", "pdf_views"=>"8", "xml_views"=>"2", "html_views"=>"75"}
  • {"month"=>"9", "year"=>"2014", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"64"}
  • {"month"=>"10", "year"=>"2014", "pdf_views"=>"15", "xml_views"=>"2", "html_views"=>"109"}
  • {"month"=>"11", "year"=>"2014", "pdf_views"=>"9", "xml_views"=>"3", "html_views"=>"153"}
  • {"month"=>"12", "year"=>"2014", "pdf_views"=>"8", "xml_views"=>"2", "html_views"=>"82"}
  • {"month"=>"1", "year"=>"2015", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"54"}
  • {"month"=>"2", "year"=>"2015", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"48"}
  • {"month"=>"3", "year"=>"2015", "pdf_views"=>"14", "xml_views"=>"1", "html_views"=>"64"}
  • {"month"=>"4", "year"=>"2015", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"53"}
  • {"month"=>"5", "year"=>"2015", "pdf_views"=>"12", "xml_views"=>"1", "html_views"=>"49"}
  • {"month"=>"6", "year"=>"2015", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"61"}
  • {"month"=>"7", "year"=>"2015", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"36"}
  • {"month"=>"8", "year"=>"2015", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"43"}
  • {"month"=>"9", "year"=>"2015", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"43"}
  • {"month"=>"10", "year"=>"2015", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"51"}
  • {"month"=>"11", "year"=>"2015", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"72"}
  • {"month"=>"12", "year"=>"2015", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"47"}
  • {"month"=>"1", "year"=>"2016", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"57"}
  • {"month"=>"2", "year"=>"2016", "pdf_views"=>"15", "xml_views"=>"0", "html_views"=>"34"}
  • {"month"=>"3", "year"=>"2016", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"43"}
  • {"month"=>"4", "year"=>"2016", "pdf_views"=>"14", "xml_views"=>"0", "html_views"=>"47"}
  • {"month"=>"5", "year"=>"2016", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"48"}
  • {"month"=>"6", "year"=>"2016", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"28"}
  • {"month"=>"7", "year"=>"2016", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"35"}
  • {"month"=>"8", "year"=>"2016", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"43"}
  • {"month"=>"9", "year"=>"2016", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"48"}
  • {"month"=>"10", "year"=>"2016", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"38"}
  • {"month"=>"11", "year"=>"2016", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"43"}
  • {"month"=>"12", "year"=>"2016", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"38"}
  • {"month"=>"1", "year"=>"2017", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"40"}
  • {"month"=>"2", "year"=>"2017", "pdf_views"=>"11", "xml_views"=>"1", "html_views"=>"45"}
  • {"month"=>"3", "year"=>"2017", "pdf_views"=>"6", "xml_views"=>"1", "html_views"=>"32"}
  • {"month"=>"4", "year"=>"2017", "pdf_views"=>"6", "xml_views"=>"1", "html_views"=>"89"}
  • {"month"=>"5", "year"=>"2017", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"26"}
  • {"month"=>"6", "year"=>"2017", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"29"}
  • {"month"=>"7", "year"=>"2017", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"153"}
  • {"month"=>"8", "year"=>"2017", "pdf_views"=>"15", "xml_views"=>"0", "html_views"=>"111"}
  • {"month"=>"9", "year"=>"2017", "pdf_views"=>"5", "xml_views"=>"2", "html_views"=>"117"}
  • {"month"=>"10", "year"=>"2017", "pdf_views"=>"4", "xml_views"=>"1", "html_views"=>"127"}
  • {"month"=>"11", "year"=>"2017", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"118"}
  • {"month"=>"12", "year"=>"2017", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"92"}
  • {"month"=>"1", "year"=>"2018", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"61"}
  • {"month"=>"2", "year"=>"2018", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"16"}
  • {"month"=>"3", "year"=>"2018", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"13"}
  • {"month"=>"4", "year"=>"2018", "pdf_views"=>"16", "xml_views"=>"0", "html_views"=>"27"}
  • {"month"=>"5", "year"=>"2018", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"18"}
  • {"month"=>"6", "year"=>"2018", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"18"}
  • {"month"=>"7", "year"=>"2018", "pdf_views"=>"6", "xml_views"=>"5", "html_views"=>"18"}
  • {"month"=>"8", "year"=>"2018", "pdf_views"=>"6", "xml_views"=>"2", "html_views"=>"13"}
  • {"month"=>"9", "year"=>"2018", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"17"}
  • {"month"=>"10", "year"=>"2018", "pdf_views"=>"11", "xml_views"=>"1", "html_views"=>"25"}
  • {"month"=>"11", "year"=>"2018", "pdf_views"=>"10", "xml_views"=>"1", "html_views"=>"9"}
  • {"month"=>"12", "year"=>"2018", "pdf_views"=>"7", "xml_views"=>"2", "html_views"=>"14"}
  • {"month"=>"1", "year"=>"2019", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"12"}
  • {"month"=>"2", "year"=>"2019", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"18"}
  • {"month"=>"3", "year"=>"2019", "pdf_views"=>"9", "xml_views"=>"1", "html_views"=>"19"}
  • {"month"=>"4", "year"=>"2019", "pdf_views"=>"14", "xml_views"=>"0", "html_views"=>"17"}
  • {"month"=>"5", "year"=>"2019", "pdf_views"=>"14", "xml_views"=>"0", "html_views"=>"16"}
  • {"month"=>"6", "year"=>"2019", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"15"}
  • {"month"=>"7", "year"=>"2019", "pdf_views"=>"15", "xml_views"=>"0", "html_views"=>"23"}
  • {"month"=>"8", "year"=>"2019", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"7"}

Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/413843", "https://ndownloader.figshare.com/files/413868", "https://ndownloader.figshare.com/files/413902", "https://ndownloader.figshare.com/files/413931", "https://ndownloader.figshare.com/files/413963", "https://ndownloader.figshare.com/files/413985", "https://ndownloader.figshare.com/files/414016", "https://ndownloader.figshare.com/files/414026", "https://ndownloader.figshare.com/files/414040", "https://ndownloader.figshare.com/files/414052"], "description"=>"<div><p>While recent scans for genetic variation associated with human disease have been immensely successful in uncovering large numbers of loci, far fewer studies have focused on the underlying pathways of disease pathogenesis. Many loci which are associated with disease and complex phenotypes map to non-coding, regulatory regions of the genome, indicating that modulation of gene transcription plays a key role. Thus, this study generated genome-wide profiles of both genetic and transcriptional variation from the total blood extracts of over 500 randomly-selected, unrelated individuals. Using measurements of blood lipids, key players in the progression of atherosclerosis, three levels of biological information are integrated in order to investigate the interactions between circulating leukocytes and proximal lipid compounds. Pair-wise correlations between gene expression and lipid concentration indicate a prominent role for basophil granulocytes and mast cells, cell types central to powerful allergic and inflammatory responses. Network analysis of gene co-expression showed that the top associations function as part of a single, previously unknown gene module, the Lipid Leukocyte (LL) module. This module replicated in T cells from an independent cohort while also displaying potential tissue specificity. Further, genetic variation driving LL module expression included the single nucleotide polymorphism (SNP) most strongly associated with serum immunoglobulin E (IgE) levels, a key antibody in allergy. Structural Equation Modeling (SEM) indicated that LL module is at least partially reactive to blood lipid levels. Taken together, this study uncovers a gene network linking blood lipids and circulating cell types and offers insight into the hypothesis that the inflammatory response plays a prominent role in metabolism and the potential control of atherogenesis.</p></div>", "links"=>[], "tags"=>["lipid", "levels"], "article_id"=>141747, "categories"=>["Genetics", "Medicine"], "users"=>["Michael Inouye", "Kaisa Silander", "Eija Hamalainen", "Veikko Salomaa", "Kennet Harald", "Pekka Jousilahti", "Satu Männistö", "Johan G. Eriksson", "Janna Saarela", "Samuli Ripatti", "Markus Perola", "Gert-Jan B. van Ommen", "Marja-Riitta Taskinen", "Aarno Palotie", "Emmanouil T. Dermitzakis", "Leena Peltonen"], "doi"=>["https://dx.doi.org/10.1371/journal.pgen.1001113.s001", "https://dx.doi.org/10.1371/journal.pgen.1001113.s002", "https://dx.doi.org/10.1371/journal.pgen.1001113.s003", "https://dx.doi.org/10.1371/journal.pgen.1001113.s004", "https://dx.doi.org/10.1371/journal.pgen.1001113.s005", "https://dx.doi.org/10.1371/journal.pgen.1001113.s006", "https://dx.doi.org/10.1371/journal.pgen.1001113.s007", "https://dx.doi.org/10.1371/journal.pgen.1001113.s008", "https://dx.doi.org/10.1371/journal.pgen.1001113.s009", "https://dx.doi.org/10.1371/journal.pgen.1001113.s010"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/An_Immune_Response_Network_Associated_with_Blood_Lipid_Levels/141747", "title"=>"An Immune Response Network Associated with Blood Lipid Levels", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2010-09-09 00:29:07"}
  • {"files"=>["https://ndownloader.figshare.com/files/830560"], "description"=>"<p>For each lipid trait and each module expression profile, a Spearman rank correlation was performed. Each row corresponds to a module (arbitrarily lettered from A to W) and each column a particular lipid trait. Each cell contains the probability that a correlation exists by chance and is color-coded with red indicating a strong positive correlation and green a strong negative correlation. The module most strongly associated with lipid traits was module K. The genes composing this module, the Lipid Leukocyte (LL) module, show that many of the top signals from a standard linear regression were part of the same sub-network.</p>", "links"=>[], "tags"=>["module", "associations", "lipid"], "article_id"=>500911, "categories"=>["Genetics", "Medicine"], "users"=>["Michael Inouye", "Kaisa Silander", "Eija Hamalainen", "Veikko Salomaa", "Kennet Harald", "Pekka Jousilahti", "Satu Männistö", "Johan G. Eriksson", "Janna Saarela", "Samuli Ripatti", "Markus Perola", "Gert-Jan B. van Ommen", "Marja-Riitta Taskinen", "Aarno Palotie", "Emmanouil T. Dermitzakis", "Leena Peltonen"], "doi"=>["https://dx.doi.org/10.1371/journal.pgen.1001113.g001"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Network_module_associations_with_lipid_traits_/500911", "title"=>"Network module associations with lipid traits.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2010-09-09 00:15:11"}
  • {"files"=>["https://ndownloader.figshare.com/files/830682"], "description"=>"<p>The co-expression patterns of the network and the LL module were rendered using BiolayoutExpress3D <a href=\"http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1001113#pgen.1001113-Freeman1\" target=\"_blank\">[60]</a>. Each node is a gene (node size is not significant) and each edge is colored according to the absolute value of the Pearson correlation between two nodes, red being strong and blue being weak. The LL module has been colored yellow and, within the topology of the network (right panel), has been enlarged relative to other nodes. The topology of the network has been edge filtered (Pearson<0.65) in order to make strong correlations clearer.</p>", "links"=>[], "tags"=>["ll"], "article_id"=>501038, "categories"=>["Genetics", "Medicine"], "users"=>["Michael Inouye", "Kaisa Silander", "Eija Hamalainen", "Veikko Salomaa", "Kennet Harald", "Pekka Jousilahti", "Satu Männistö", "Johan G. Eriksson", "Janna Saarela", "Samuli Ripatti", "Markus Perola", "Gert-Jan B. van Ommen", "Marja-Riitta Taskinen", "Aarno Palotie", "Emmanouil T. Dermitzakis", "Leena Peltonen"], "doi"=>["https://dx.doi.org/10.1371/journal.pgen.1001113.g002"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Topology_of_the_network_and_the_LL_module_/501038", "title"=>"Topology of the network and the LL module.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2010-09-09 00:17:18"}
  • {"files"=>["https://ndownloader.figshare.com/files/830781"], "description"=>"<p>In the LL module, there is a strong positive correlation between the intra-modular connectivity of a node (gene) and its association with APOB, HDL, and TG levels, showing that the approximately eight genes inter-connected are also the most associated with lipid traits. These genes constitute the core of the LL module.</p>", "links"=>[], "tags"=>["ll"], "article_id"=>501136, "categories"=>["Genetics", "Medicine"], "users"=>["Michael Inouye", "Kaisa Silander", "Eija Hamalainen", "Veikko Salomaa", "Kennet Harald", "Pekka Jousilahti", "Satu Männistö", "Johan G. Eriksson", "Janna Saarela", "Samuli Ripatti", "Markus Perola", "Gert-Jan B. van Ommen", "Marja-Riitta Taskinen", "Aarno Palotie", "Emmanouil T. Dermitzakis", "Leena Peltonen"], "doi"=>["https://dx.doi.org/10.1371/journal.pgen.1001113.g003"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Connectivity_and_trait_association_within_the_LL_module_/501136", "title"=>"Connectivity and trait association within the LL module.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2010-09-09 00:18:56"}
  • {"files"=>["https://ndownloader.figshare.com/files/830880"], "description"=>"<p>For each <i>cis</i> SNP proximal to <i>FCER1A</i> and <i>SLC45A3</i>, a simple linear model is fitted and the regression <i>P</i> value (−log10 transformed) plotted along the vertical axis with genomic position of the SNP along the horizontal axis (both on chromosome 1). The two adjacent SNPs passing a permutation threshold of 0.05 are denoted by red dots while the SNP (rs2251746) within <i>FCER1A</i> found to drive expression of the LL module is circled in red. The position of the expression probe and the direction of transcription are denoted by a green arrow.</p>", "links"=>[], "tags"=>["computational biology/systems biology", "genetics and genomics/bioinformatics", "genetics and genomics/gene expression"], "article_id"=>501229, "categories"=>["Genetics", "Medicine"], "users"=>["Michael Inouye", "Kaisa Silander", "Eija Hamalainen", "Veikko Salomaa", "Kennet Harald", "Pekka Jousilahti", "Satu Männistö", "Johan G. Eriksson", "Janna Saarela", "Samuli Ripatti", "Markus Perola", "Gert-Jan B. van Ommen", "Marja-Riitta Taskinen", "Aarno Palotie", "Emmanouil T. Dermitzakis", "Leena Peltonen"], "doi"=>["https://dx.doi.org/10.1371/journal.pgen.1001113.g004"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Association_of_genetic_variation_with_expression_of_FCER1A_and_SLC45A3_/501229", "title"=>"Association of genetic variation with expression of <i>FCER1A</i> and <i>SLC45A3</i>.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2010-09-09 00:20:29"}
  • {"files"=>["https://ndownloader.figshare.com/files/830970"], "description"=>"<p>NEO was used to generate an edge-oriented network of triglycerides, HDL, and core LL module genes. Blue edges denote significant correlations between SNPs and nodes (orange circles), black edges denote significant correlations between nodes with a corresponding LEO score greater than 0.3 (predicted as a causal edge) while grey edges denote significant correlations between nodes with a LEO score less than 0.3 (causality is inconclusive). Dotted edges signify causal model fitted <i>P</i> values <0.05.</p>", "links"=>[], "tags"=>["directed", "ll"], "article_id"=>501317, "categories"=>["Genetics", "Medicine"], "users"=>["Michael Inouye", "Kaisa Silander", "Eija Hamalainen", "Veikko Salomaa", "Kennet Harald", "Pekka Jousilahti", "Satu Männistö", "Johan G. Eriksson", "Janna Saarela", "Samuli Ripatti", "Markus Perola", "Gert-Jan B. van Ommen", "Marja-Riitta Taskinen", "Aarno Palotie", "Emmanouil T. Dermitzakis", "Leena Peltonen"], "doi"=>["https://dx.doi.org/10.1371/journal.pgen.1001113.g005"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_The_directed_network_of_core_LL_module_HDL_and_triglycerides_/501317", "title"=>"The directed network of core LL module, HDL, and triglycerides.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2010-09-09 00:21:57"}
  • {"files"=>["https://ndownloader.figshare.com/files/831047"], "description"=>"<p>Genes showing significant evidence of association with specific lipid traits.</p>", "links"=>[], "tags"=>["lipid"], "article_id"=>501400, "categories"=>["Genetics", "Medicine"], "users"=>["Michael Inouye", "Kaisa Silander", "Eija Hamalainen", "Veikko Salomaa", "Kennet Harald", "Pekka Jousilahti", "Satu Männistö", "Johan G. Eriksson", "Janna Saarela", "Samuli Ripatti", "Markus Perola", "Gert-Jan B. van Ommen", "Marja-Riitta Taskinen", "Aarno Palotie", "Emmanouil T. Dermitzakis", "Leena Peltonen"], "doi"=>["https://dx.doi.org/10.1371/journal.pgen.1001113.t003"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Genes_showing_significant_evidence_of_association_with_specific_lipid_traits_/501400", "title"=>"Genes showing significant evidence of association with specific lipid traits.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2010-09-09 00:23:20"}
  • {"files"=>["https://ndownloader.figshare.com/files/831096"], "description"=>"<p>CM = cholesterol lowering medication (Yes or No).</p><p>HTM = hypertension medication (Yes or No).</p><p>Alcohol = alcohol intake in previous 7 days (grams).</p><p>For those DILGOM individuals passing quality control (N = 518), the proportion using HTM was 20.5% (18.7% of females, 22.5% of males) and the proportion using CM was 14.3% (10.1% of females, 19.2% of males).</p>", "links"=>[], "tags"=>["regression"], "article_id"=>501451, "categories"=>["Genetics", "Medicine"], "users"=>["Michael Inouye", "Kaisa Silander", "Eija Hamalainen", "Veikko Salomaa", "Kennet Harald", "Pekka Jousilahti", "Satu Männistö", "Johan G. Eriksson", "Janna Saarela", "Samuli Ripatti", "Markus Perola", "Gert-Jan B. van Ommen", "Marja-Riitta Taskinen", "Aarno Palotie", "Emmanouil T. Dermitzakis", "Leena Peltonen"], "doi"=>["https://dx.doi.org/10.1371/journal.pgen.1001113.t002"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Multiple_regression_covariates_/501451", "title"=>"Multiple regression covariates.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2010-09-09 00:24:11"}
  • {"files"=>["https://ndownloader.figshare.com/files/831147"], "description"=>"<p>Lipid traits of the DILGOM population sample.</p>", "links"=>[], "tags"=>["dilgom"], "article_id"=>501501, "categories"=>["Genetics", "Medicine"], "users"=>["Michael Inouye", "Kaisa Silander", "Eija Hamalainen", "Veikko Salomaa", "Kennet Harald", "Pekka Jousilahti", "Satu Männistö", "Johan G. Eriksson", "Janna Saarela", "Samuli Ripatti", "Markus Perola", "Gert-Jan B. van Ommen", "Marja-Riitta Taskinen", "Aarno Palotie", "Emmanouil T. Dermitzakis", "Leena Peltonen"], "doi"=>["https://dx.doi.org/10.1371/journal.pgen.1001113.t001"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Lipid_traits_of_the_DILGOM_population_sample_/501501", "title"=>"Lipid traits of the DILGOM population sample.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2010-09-09 00:25:01"}
  • {"files"=>["https://ndownloader.figshare.com/files/831195"], "description"=>"<p>LL core directed network statistics.</p>", "links"=>[], "tags"=>["directed"], "article_id"=>501552, "categories"=>["Genetics", "Medicine"], "users"=>["Michael Inouye", "Kaisa Silander", "Eija Hamalainen", "Veikko Salomaa", "Kennet Harald", "Pekka Jousilahti", "Satu Männistö", "Johan G. Eriksson", "Janna Saarela", "Samuli Ripatti", "Markus Perola", "Gert-Jan B. van Ommen", "Marja-Riitta Taskinen", "Aarno Palotie", "Emmanouil T. Dermitzakis", "Leena Peltonen"], "doi"=>["https://dx.doi.org/10.1371/journal.pgen.1001113.t007"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_LL_core_directed_network_statistics_/501552", "title"=>"LL core directed network statistics.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2010-09-09 00:25:52"}
  • {"files"=>["https://ndownloader.figshare.com/files/831258"], "description"=>"<p>Each core gene in the LL module was tested for co-expression against all other core genes in the LL module using Spearman's rank correlation coefficient. This was done across three datasets: whole blood extracts from the DILGOM cohort (N = 518), primary T cells from GenChord individuals (N = 75), and EBV-transformed B cells from the same GenCord individuals. Given 21 tests for each cohort, the Bonferroni corrected significance level is 2.38×10<sup>−3</sup>.</p>", "links"=>[], "tags"=>["module", "co-expression", "gencord"], "article_id"=>501610, "categories"=>["Genetics", "Medicine"], "users"=>["Michael Inouye", "Kaisa Silander", "Eija Hamalainen", "Veikko Salomaa", "Kennet Harald", "Pekka Jousilahti", "Satu Männistö", "Johan G. Eriksson", "Janna Saarela", "Samuli Ripatti", "Markus Perola", "Gert-Jan B. van Ommen", "Marja-Riitta Taskinen", "Aarno Palotie", "Emmanouil T. Dermitzakis", "Leena Peltonen"], "doi"=>["https://dx.doi.org/10.1371/journal.pgen.1001113.t006"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_LL_module_core_gene_co_expression_in_the_GenCord_cohort_/501610", "title"=>"LL module core gene co-expression in the GenCord cohort.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2010-09-09 00:26:50"}
  • {"files"=>["https://ndownloader.figshare.com/files/831309"], "description"=>"<p>The linear models are the same as in <a href=\"http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1001113#pgen-1001113-t001\" target=\"_blank\">Table 1</a> of the main text, except for the addition of covariates for each of the cell-type specific expression profiles in Whitney et al <a href=\"http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1001113#pgen.1001113-Whitney1\" target=\"_blank\">[26]</a>. These include proportions of lymphocytes, neutrophils, reticulocytes, B cells, cytotoxic T lymphocytes/natural killer cells, erythrocytes, myeloid cells, and Myc-regulated cells (profiles for the time of day were also included). There were no T cell specific markers available on the Illumina HT-12. Covariates were constructed via an average standard score across all cell-type specific markers for each sample.</p>", "links"=>[], "tags"=>["cell-type", "markers"], "article_id"=>501663, "categories"=>["Genetics", "Medicine"], "users"=>["Michael Inouye", "Kaisa Silander", "Eija Hamalainen", "Veikko Salomaa", "Kennet Harald", "Pekka Jousilahti", "Satu Männistö", "Johan G. Eriksson", "Janna Saarela", "Samuli Ripatti", "Markus Perola", "Gert-Jan B. van Ommen", "Marja-Riitta Taskinen", "Aarno Palotie", "Emmanouil T. Dermitzakis", "Leena Peltonen"], "doi"=>["https://dx.doi.org/10.1371/journal.pgen.1001113.t005"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Significance_of_HDC_FCER1A_CPA3_SLC45A3_and_GATA2_with_cell_type_specific_expression_markers_as_covariates_/501663", "title"=>"Significance of <i>HDC</i>, <i>FCER1A</i>, <i>CPA3</i>, <i>SLC45A3</i>, and <i>GATA2</i> with cell-type specific expression markers as covariates.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2010-09-09 00:27:43"}
  • {"files"=>["https://ndownloader.figshare.com/files/831364"], "description"=>"<p><i>HDC</i>, <i>FCER1A</i>, <i>CPA3</i>, <i>SLC45A3</i>, and <i>GATA2</i> show significant association with the APOB/APOA1 ratio.</p>", "links"=>[], "tags"=>["computational biology/systems biology", "genetics and genomics/bioinformatics", "genetics and genomics/gene expression"], "article_id"=>501710, "categories"=>["Genetics", "Medicine"], "users"=>["Michael Inouye", "Kaisa Silander", "Eija Hamalainen", "Veikko Salomaa", "Kennet Harald", "Pekka Jousilahti", "Satu Männistö", "Johan G. Eriksson", "Janna Saarela", "Samuli Ripatti", "Markus Perola", "Gert-Jan B. van Ommen", "Marja-Riitta Taskinen", "Aarno Palotie", "Emmanouil T. Dermitzakis", "Leena Peltonen"], "doi"=>["https://dx.doi.org/10.1371/journal.pgen.1001113.t004"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_HDC_FCER1A_CPA3_SLC45A3_and_GATA2_show_significant_association_with_the_APOB_APOA1_ratio_/501710", "title"=>"<i>HDC</i>, <i>FCER1A</i>, <i>CPA3</i>, <i>SLC45A3</i>, and <i>GATA2</i> show significant association with the APOB/APOA1 ratio.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2010-09-09 00:28:30"}

PMC Usage Stats | Further Information

  • {"month"=>"9", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"5", "full-text"=>"68", "year"=>"2010", "pdf"=>"51", "unique-ip"=>"60", "figure"=>"4", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"10", "cited-by"=>"0", "abstract"=>"10", "full-text"=>"83", "unique-ip"=>"68", "pdf"=>"45", "year"=>"2010", "figure"=>"14", "scanned-summary"=>"0", "supp-data"=>"22"}
  • {"month"=>"11", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"3", "full-text"=>"48", "year"=>"2010", "pdf"=>"27", "unique-ip"=>"51", "figure"=>"12", "scanned-summary"=>"0", "supp-data"=>"7"}
  • {"scanned-page-browse"=>"0", "month"=>"12", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"23", "unique-ip"=>"32", "pdf"=>"12", "year"=>"2010", "figure"=>"9", "scanned-summary"=>"0", "supp-data"=>"1"}
  • {"month"=>"1", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"75", "year"=>"2011", "pdf"=>"50", "unique-ip"=>"73", "figure"=>"19", "scanned-summary"=>"0", "supp-data"=>"6"}
  • {"scanned-page-browse"=>"0", "month"=>"2", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"62", "unique-ip"=>"62", "pdf"=>"40", "year"=>"2011", "figure"=>"10", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"3", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"3", "full-text"=>"48", "year"=>"2011", "pdf"=>"27", "unique-ip"=>"46", "figure"=>"15", "scanned-summary"=>"0", "supp-data"=>"1"}
  • {"scanned-page-browse"=>"0", "month"=>"4", "cited-by"=>"0", "abstract"=>"3", "full-text"=>"40", "unique-ip"=>"52", "pdf"=>"22", "year"=>"2011", "figure"=>"16", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"5", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"4", "full-text"=>"37", "year"=>"2011", "pdf"=>"25", "unique-ip"=>"40", "figure"=>"17", "scanned-summary"=>"0", "supp-data"=>"5"}
  • {"scanned-page-browse"=>"0", "month"=>"6", "cited-by"=>"0", "abstract"=>"2", "full-text"=>"31", "unique-ip"=>"31", "pdf"=>"18", "year"=>"2011", "figure"=>"8", "scanned-summary"=>"0", "supp-data"=>"3"}
  • {"month"=>"7", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"24", "year"=>"2011", "pdf"=>"15", "unique-ip"=>"26", "figure"=>"6", "scanned-summary"=>"0", "supp-data"=>"5"}
  • {"scanned-page-browse"=>"0", "month"=>"8", "cited-by"=>"0", "abstract"=>"2", "full-text"=>"26", "unique-ip"=>"32", "pdf"=>"12", "year"=>"2011", "figure"=>"10", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"9", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"37", "year"=>"2011", "pdf"=>"20", "unique-ip"=>"38", "figure"=>"14", "scanned-summary"=>"0", "supp-data"=>"2"}
  • {"scanned-page-browse"=>"0", "month"=>"10", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"41", "unique-ip"=>"39", "pdf"=>"25", "year"=>"2011", "figure"=>"12", "scanned-summary"=>"0", "supp-data"=>"9"}
  • {"month"=>"11", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"17", "year"=>"2011", "pdf"=>"14", "unique-ip"=>"18", "figure"=>"1", "scanned-summary"=>"0", "supp-data"=>"7"}
  • {"scanned-page-browse"=>"0", "month"=>"12", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"15", "unique-ip"=>"16", "pdf"=>"6", "year"=>"2011", "figure"=>"2", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"1", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"19", "unique-ip"=>"21", "pdf"=>"12", "year"=>"2012", "figure"=>"1", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"2", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"19", "year"=>"2012", "pdf"=>"8", "unique-ip"=>"18", "figure"=>"9", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"3", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"23", "unique-ip"=>"24", "pdf"=>"16", "year"=>"2012", "figure"=>"2", "scanned-summary"=>"0", "supp-data"=>"1"}
  • {"month"=>"4", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"2", "full-text"=>"26", "year"=>"2012", "pdf"=>"11", "unique-ip"=>"25", "figure"=>"5", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"5", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"22", "unique-ip"=>"24", "pdf"=>"17", "year"=>"2012", "figure"=>"7", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"6", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"12", "year"=>"2012", "pdf"=>"10", "unique-ip"=>"14", "figure"=>"6", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"unique-ip"=>"14", "full-text"=>"26", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"9", "cited-by"=>"0", "year"=>"2012", "month"=>"7"}
  • {"unique-ip"=>"16", "full-text"=>"16", "pdf"=>"2", "abstract"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"8"}
  • {"unique-ip"=>"16", "full-text"=>"15", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"9"}
  • {"unique-ip"=>"13", "full-text"=>"18", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2012", "month"=>"10"}
  • {"unique-ip"=>"5", "full-text"=>"5", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"12"}
  • {"unique-ip"=>"6", "full-text"=>"7", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"1"}
  • {"unique-ip"=>"11", "full-text"=>"10", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"2"}
  • {"unique-ip"=>"12", "full-text"=>"9", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2013", "month"=>"3"}
  • {"unique-ip"=>"8", "full-text"=>"9", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"8", "cited-by"=>"0", "year"=>"2013", "month"=>"4"}
  • {"unique-ip"=>"12", "full-text"=>"11", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2012", "month"=>"11"}
  • {"unique-ip"=>"10", "full-text"=>"8", "pdf"=>"2", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"5"}
  • {"unique-ip"=>"22", "full-text"=>"26", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"3", "year"=>"2013", "month"=>"6"}
  • {"unique-ip"=>"7", "full-text"=>"7", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"7"}
  • {"unique-ip"=>"12", "full-text"=>"12", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"20", "cited-by"=>"0", "year"=>"2013", "month"=>"8"}
  • {"unique-ip"=>"16", "full-text"=>"15", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"9"}
  • {"unique-ip"=>"8", "full-text"=>"7", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"10"}
  • {"unique-ip"=>"8", "full-text"=>"6", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"11"}
  • {"unique-ip"=>"9", "full-text"=>"7", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"12"}
  • {"unique-ip"=>"11", "full-text"=>"8", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"1"}
  • {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"2"}
  • {"unique-ip"=>"10", "full-text"=>"14", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"3"}
  • {"unique-ip"=>"10", "full-text"=>"7", "pdf"=>"5", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"5"}
  • {"unique-ip"=>"12", "full-text"=>"16", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2014", "month"=>"6"}
  • {"unique-ip"=>"9", "full-text"=>"6", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"4"}
  • {"unique-ip"=>"19", "full-text"=>"21", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"7"}
  • {"unique-ip"=>"8", "full-text"=>"5", "pdf"=>"5", "abstract"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"8"}
  • {"unique-ip"=>"21", "full-text"=>"33", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"4", "cited-by"=>"0", "year"=>"2014", "month"=>"9"}
  • {"unique-ip"=>"15", "full-text"=>"16", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"11", "cited-by"=>"0", "year"=>"2014", "month"=>"10"}
  • {"unique-ip"=>"9", "full-text"=>"7", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2014", "month"=>"11"}
  • {"unique-ip"=>"13", "full-text"=>"11", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"12"}
  • {"unique-ip"=>"20", "full-text"=>"21", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"1"}
  • {"unique-ip"=>"8", "full-text"=>"7", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"2"}
  • {"unique-ip"=>"16", "full-text"=>"19", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"3"}
  • {"unique-ip"=>"14", "full-text"=>"15", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"4"}
  • {"unique-ip"=>"10", "full-text"=>"8", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"5"}
  • {"unique-ip"=>"20", "full-text"=>"22", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2015", "month"=>"6"}
  • {"unique-ip"=>"16", "full-text"=>"17", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2015", "month"=>"7"}
  • {"unique-ip"=>"19", "full-text"=>"18", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"8"}
  • {"unique-ip"=>"16", "full-text"=>"17", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"9"}
  • {"unique-ip"=>"19", "full-text"=>"15", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"4", "cited-by"=>"1", "year"=>"2015", "month"=>"10"}
  • {"unique-ip"=>"29", "full-text"=>"20", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"2", "cited-by"=>"5", "year"=>"2015", "month"=>"11"}
  • {"unique-ip"=>"16", "full-text"=>"10", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2015", "month"=>"12"}
  • {"unique-ip"=>"18", "full-text"=>"11", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"3", "cited-by"=>"1", "year"=>"2016", "month"=>"1"}
  • {"unique-ip"=>"8", "full-text"=>"6", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"2"}
  • {"unique-ip"=>"9", "full-text"=>"7", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"3"}
  • {"unique-ip"=>"16", "full-text"=>"17", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"4"}
  • {"unique-ip"=>"16", "full-text"=>"18", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2016", "month"=>"5"}
  • {"unique-ip"=>"8", "full-text"=>"11", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"6"}
  • {"unique-ip"=>"13", "full-text"=>"10", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"7"}
  • {"unique-ip"=>"7", "full-text"=>"7", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"8"}
  • {"unique-ip"=>"8", "full-text"=>"9", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"9"}
  • {"unique-ip"=>"5", "full-text"=>"4", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"10"}
  • {"unique-ip"=>"8", "full-text"=>"12", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2016", "month"=>"11"}
  • {"unique-ip"=>"14", "full-text"=>"7", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"2", "cited-by"=>"1", "year"=>"2016", "month"=>"12"}
  • {"unique-ip"=>"13", "full-text"=>"6", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"1"}
  • {"unique-ip"=>"7", "full-text"=>"7", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"2"}
  • {"unique-ip"=>"4", "full-text"=>"16", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"3"}
  • {"unique-ip"=>"11", "full-text"=>"12", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2017", "month"=>"4"}
  • {"unique-ip"=>"9", "full-text"=>"6", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"5"}
  • {"unique-ip"=>"2", "full-text"=>"2", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"6"}
  • {"unique-ip"=>"5", "full-text"=>"4", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2017", "month"=>"7"}
  • {"unique-ip"=>"6", "full-text"=>"2", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"5", "cited-by"=>"0", "year"=>"2017", "month"=>"8"}
  • {"unique-ip"=>"9", "full-text"=>"9", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2017", "month"=>"9"}
  • {"unique-ip"=>"14", "full-text"=>"8", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"7", "cited-by"=>"0", "year"=>"2017", "month"=>"10"}
  • {"unique-ip"=>"5", "full-text"=>"5", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2017", "month"=>"11"}
  • {"unique-ip"=>"1", "full-text"=>"1", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"12"}
  • {"unique-ip"=>"5", "full-text"=>"5", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"1"}
  • {"unique-ip"=>"6", "full-text"=>"3", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"3"}
  • {"unique-ip"=>"7", "full-text"=>"6", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"1"}
  • {"unique-ip"=>"12", "full-text"=>"10", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"5"}
  • {"unique-ip"=>"6", "full-text"=>"5", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"4"}
  • {"unique-ip"=>"2", "full-text"=>"2", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2018", "month"=>"6"}
  • {"unique-ip"=>"11", "full-text"=>"7", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"5", "cited-by"=>"0", "year"=>"2018", "month"=>"7"}
  • {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"8"}
  • {"unique-ip"=>"8", "full-text"=>"8", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"9"}
  • {"unique-ip"=>"13", "full-text"=>"11", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"10"}
  • {"unique-ip"=>"12", "full-text"=>"13", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"11"}
  • {"unique-ip"=>"5", "full-text"=>"5", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"12"}
  • {"unique-ip"=>"9", "full-text"=>"8", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"2"}
  • {"unique-ip"=>"10", "full-text"=>"10", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"3"}
  • {"unique-ip"=>"5", "full-text"=>"8", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"4"}
  • {"unique-ip"=>"22", "full-text"=>"13", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"13", "supp-data"=>"5", "cited-by"=>"2", "year"=>"2019", "month"=>"5"}

Relative Metric

{"start_date"=>"2010-01-01T00:00:00Z", "end_date"=>"2010-12-31T00:00:00Z", "subject_areas"=>[{"subject_area"=>"/Biology and life sciences", "average_usage"=>[288, 576, 733, 867, 984, 1087, 1182, 1267, 1346, 1424, 1501, 1577, 1646, 1711, 1778, 1841, 1908, 1970, 2034, 2102, 2162, 2227, 2296, 2359, 2422, 2482, 2550, 2610, 2679, 2747, 2820, 2887, 2955, 3009, 3067, 3130, 3200, 3257, 3322, 3379, 3443, 3507, 3571, 3632, 3683, 3753, 3822, 3877]}, {"subject_area"=>"/Biology and life sciences/Biochemistry", "average_usage"=>[283, 565, 720, 852, 970, 1070, 1168, 1258, 1336, 1411, 1487, 1571, 1640, 1709, 1776, 1843, 1906, 1969, 2031, 2086, 2152, 2221, 2286, 2361, 2419, 2480, 2543, 2598, 2665, 2731, 2802, 2868, 2932, 2996, 3053, 3114, 3169, 3232, 3289, 3355, 3413, 3473, 3530, 3595, 3648, 3711, 3764, 3810, 3863]}, {"subject_area"=>"/Biology and life sciences/Genetics", "average_usage"=>[306, 610, 768, 915, 1043, 1164, 1255, 1349, 1432, 1511, 1592, 1674, 1744, 1817, 1889, 1950, 2028, 2087, 2153, 2217, 2274, 2349, 2418, 2488, 2558, 2616, 2686, 2745, 2809, 2869, 2938, 3008, 3071, 3131, 3189, 3258, 3320, 3389, 3446, 3503, 3552, 3613, 3677, 3744, 3788, 3842, 3907, 3966, 4015]}, {"subject_area"=>"/Biology and life sciences/Immunology", "average_usage"=>[266, 530, 683, 806, 930, 1032, 1122, 1207, 1292, 1362, 1433, 1495, 1565, 1621, 1680, 1737, 1792, 1851, 1901, 1967, 2022, 2075, 2150, 2203, 2250, 2314, 2367, 2416, 2472, 2531, 2603, 2651, 2707, 2756, 2800, 2877, 2936, 2986, 3036, 3083, 3131, 3191, 3253, 3313, 3376, 3437, 3496, 3556]}, {"subject_area"=>"/Medicine and health sciences", "average_usage"=>[277, 558, 715, 845, 963, 1070, 1166, 1258, 1336, 1410, 1485, 1561, 1638, 1707, 1767, 1834, 1896, 1960, 2030, 2096, 2165, 2229, 2300, 2368, 2425, 2489, 2553, 2617, 2679, 2743, 2814, 2873, 2941, 2995, 3050, 3111, 3169, 3235, 3300, 3363, 3428, 3487, 3548, 3605, 3670, 3726, 3785, 3844]}, {"subject_area"=>"/Medicine and health sciences/Anatomy", "average_usage"=>[268, 527, 681, 804, 923, 1031, 1126, 1210, 1284, 1361, 1440, 1508, 1578, 1631, 1688, 1754, 1816, 1877, 1945, 2003, 2060, 2125, 2183, 2253, 2313, 2379, 2436, 2513, 2570, 2626, 2702, 2757, 2809, 2885, 2945, 3006, 3067, 3128, 3180, 3237, 3290, 3347, 3397, 3462, 3520, 3585, 3651, 3706, 3755]}, {"subject_area"=>"/Medicine and health sciences/Hematology", "average_usage"=>[241, 488, 623, 737, 840, 951, 1047, 1112, 1189, 1261, 1341, 1404, 1474, 1528, 1595, 1658, 1712, 1771, 1829, 1889, 1947, 2000, 2062, 2129, 2201, 2253, 2310, 2364, 2426, 2486, 2561, 2600, 2653, 2711, 2768, 2816, 2876, 2938, 2989, 3047, 3103, 3158, 3193, 3272, 3307, 3368, 3454, 3512, 3566]}]}
Loading … Spinner
There are currently no alerts