Genome-Wide Association Study of Blood Pressure Extremes Identifies Variant near UMOD Associated with Hypertension
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{"title"=>"Genome-wide association study of blood pressure extremes identifies variant near UMOD associated with hypertension", "type"=>"journal", "authors"=>[{"first_name"=>"Sandosh", "last_name"=>"Padmanabhan", "scopus_author_id"=>"7005770659"}, {"first_name"=>"Olle", "last_name"=>"Melander", "scopus_author_id"=>"7004120938"}, {"first_name"=>"Toby", "last_name"=>"Johnson", "scopus_author_id"=>"7404019093"}, {"first_name"=>"Anna Maria", "last_name"=>"Di Blasio", "scopus_author_id"=>"7005007229"}, {"first_name"=>"Wai K.", "last_name"=>"Lee", "scopus_author_id"=>"57194896002"}, {"first_name"=>"Davide", "last_name"=>"Gentilini", "scopus_author_id"=>"25644685700"}, {"first_name"=>"Claire E.", "last_name"=>"Hastie", "scopus_author_id"=>"24075937100"}, {"first_name"=>"Cristina", "last_name"=>"Menni", "scopus_author_id"=>"25622426300"}, {"first_name"=>"Maria Cristina", "last_name"=>"Monti", "scopus_author_id"=>"56371268600"}, {"first_name"=>"Christian", "last_name"=>"Delles", 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"last_name"=>"Loos", "scopus_author_id"=>"7006771047"}, {"first_name"=>"Nicholas J.", "last_name"=>"Wareham", "scopus_author_id"=>"7006224498"}, {"first_name"=>"Brenda W.", "last_name"=>"Penninx", "scopus_author_id"=>"55800249300"}, {"first_name"=>"Ilja M.", "last_name"=>"Nolte", "scopus_author_id"=>"7102054770"}, {"first_name"=>"Martin", "last_name"=>"McBride", "scopus_author_id"=>"7201955024"}, {"first_name"=>"William H.", "last_name"=>"Miller", "scopus_author_id"=>"56874782100"}, {"first_name"=>"Stuart A.", "last_name"=>"Nicklin", "scopus_author_id"=>"7003912384"}, {"first_name"=>"Andrew H.", "last_name"=>"Baker", "scopus_author_id"=>"7403519922"}, {"first_name"=>"Delyth", "last_name"=>"Graham", "scopus_author_id"=>"7403477386"}, {"first_name"=>"Robert A.", "last_name"=>"McDonald", "scopus_author_id"=>"36554427600"}, {"first_name"=>"Jill P.", "last_name"=>"Pell", "scopus_author_id"=>"7102902457"}, {"first_name"=>"Naveed", "last_name"=>"Sattar", "scopus_author_id"=>"7007043802"}, {"first_name"=>"Paul", "last_name"=>"Welsh", "scopus_author_id"=>"35308260700"}, {"first_name"=>"Patricia", "last_name"=>"Munroe", "scopus_author_id"=>"7005376453"}, {"first_name"=>"Mark J.", "last_name"=>"Caulfield", "scopus_author_id"=>"7102853527"}, {"first_name"=>"Alberto", "last_name"=>"Zanchetti", "scopus_author_id"=>"36038053000"}, {"first_name"=>"Anna F.", "last_name"=>"Dominiczak", "scopus_author_id"=>"7005462773"}], "year"=>2010, "source"=>"PLoS Genetics", "identifiers"=>{"pui"=>"359979463", "sgr"=>"78449233580", "issn"=>"15537404", "pmid"=>"21082022", "scopus"=>"2-s2.0-78449233580", "doi"=>"10.1371/journal.pgen.1001177", "isbn"=>"1553-7390"}, "id"=>"c8e76757-5537-395a-a1d9-8f0007a6f7f9", "abstract"=>"Hypertension is a heritable and major contributor to the global burden of disease. The sum of rare and common genetic variants robustly identified so far explain only 1%-2% of the population variation in BP and hypertension. This suggests the existence of more undiscovered common variants. We conducted a genome-wide association study in 1,621 hypertensive cases and 1,699 controls and follow-up validation analyses in 19,845 cases and 16,541 controls using an extreme case-control design. We identified a locus on chromosome 16 in the 5' region of Uromodulin (UMOD; rs13333226, combined P value of 3.6 × 10⁻¹¹). The minor G allele is associated with a lower risk of hypertension (OR [95%CI]: 0.87 [0.84-0.91]), reduced urinary uromodulin excretion, better renal function; and each copy of the G allele is associated with a 7.7% reduction in risk of CVD events after adjusting for age, sex, BMI, and smoking status (H.R. = 0.923, 95% CI 0.860-0.991; p = 0.027). In a subset of 13,446 individuals with estimated glomerular filtration rate (eGFR) measurements, we show that rs13333226 is independently associated with hypertension (unadjusted for eGFR: 0.89 [0.83-0.96], p = 0.004; after eGFR adjustment: 0.89 [0.83-0.96], p = 0.003). In clinical functional studies, we also consistently show the minor G allele is associated with lower urinary uromodulin excretion. The exclusive expression of uromodulin in the thick portion of the ascending limb of Henle suggests a putative role of this variant in hypertension through an effect on sodium homeostasis. The newly discovered UMOD locus for hypertension has the potential to give new insights into the role of uromodulin in BP regulation and to identify novel drugable targets for reducing cardiovascular risk.", "link"=>"http://www.mendeley.com/research/genomewide-association-study-blood-pressure-extremes-identifies-variant-near-umod-associated-hyperte", "reader_count"=>137, "reader_count_by_academic_status"=>{"Unspecified"=>6, "Professor > Associate Professor"=>10, "Librarian"=>1, "Student > Doctoral Student"=>5, "Researcher"=>34, "Student > Ph. D. Student"=>33, "Student > Postgraduate"=>6, "Student > Master"=>12, "Other"=>11, "Student > Bachelor"=>6, "Lecturer"=>2, "Lecturer > Senior Lecturer"=>1, "Professor"=>10}, "reader_count_by_user_role"=>{"Unspecified"=>6, "Professor > Associate Professor"=>10, "Librarian"=>1, "Student > Doctoral Student"=>5, "Researcher"=>34, "Student > Ph. D. Student"=>33, "Student > Postgraduate"=>6, "Student > Master"=>12, "Other"=>11, "Student > Bachelor"=>6, "Lecturer"=>2, "Lecturer > Senior Lecturer"=>1, "Professor"=>10}, "reader_count_by_subject_area"=>{"Unspecified"=>9, "Agricultural and Biological Sciences"=>43, "Chemistry"=>1, "Computer Science"=>1, "Environmental Science"=>1, "Biochemistry, Genetics and Molecular Biology"=>13, "Mathematics"=>2, "Medicine and Dentistry"=>61, "Neuroscience"=>1, "Pharmacology, Toxicology and Pharmaceutical Science"=>2, "Psychology"=>1, "Social Sciences"=>1, "Linguistics"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>61}, "Social Sciences"=>{"Social Sciences"=>1}, "Psychology"=>{"Psychology"=>1}, "Mathematics"=>{"Mathematics"=>2}, "Unspecified"=>{"Unspecified"=>9}, "Environmental Science"=>{"Environmental Science"=>1}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>2}, "Chemistry"=>{"Chemistry"=>1}, "Neuroscience"=>{"Neuroscience"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>43}, "Computer Science"=>{"Computer Science"=>1}, "Linguistics"=>{"Linguistics"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>13}}, "reader_count_by_country"=>{"Taiwan"=>1, "Italy"=>1, "United Kingdom"=>2, "France"=>1, "Kenya"=>1, "Spain"=>2}, "group_count"=>10}

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/822440"], "description"=>"<p>Demographic characteristics of the discovery case control population.</p>", "links"=>[], "tags"=>["characteristics"], "article_id"=>492704, "categories"=>["Genetics", "Computational Biology"], "users"=>["Sandosh Padmanabhan", "Olle Melander", "Toby Johnson", "Anna Maria Di Blasio", "Wai K. Lee", "Davide Gentilini", "Claire E. Hastie", "Cristina Menni", "Maria Cristina Monti", "Christian Delles", "Stewart Laing", "Barbara Corso", "Gerjan Navis", "Arjan J. Kwakernaak", "Pim van der Harst", "Murielle Bochud", "Marc Maillard", "Michel Burnier", "Thomas Hedner", "Sverre Kjeldsen", "Björn Wahlstrand", "Marketa Sjögren", "Cristiano Fava", "Martina Montagnana", "Elisa Danese", "Ole Torffvit", "Bo Hedblad", "Harold Snieder", "John M. C. Connell", "Morris Brown", "Nilesh J. Samani", "Martin Farrall", "Giancarlo Cesana", "Giuseppe Mancia", "Stefano Signorini", "Guido Grassi", "Susana Eyheramendy", "H. Erich Wichmann", "Maris Laan", "David P. Strachan", "Peter Sever", "Denis Colm Shields", "Alice Stanton", "Peter Vollenweider", "Alexander Teumer", "Henry Völzke", "Rainer Rettig", "Christopher Newton-Cheh", "Pankaj Arora", "Feng Zhang", "Nicole Soranzo", "Timothy D. Spector", "Gavin Lucas", "Sekar Kathiresan", "David S. Siscovick", "Jian'an Luan", "Ruth J. F. Loos", "Nicholas J. Wareham", "Brenda W. Penninx", "Ilja M. Nolte", "Martin McBride", "William H. Miller", "Stuart A. Nicklin", "Andrew H. Baker", "Delyth Graham", "Robert A. McDonald", "Jill P. Pell", "Naveed Sattar", "Paul Welsh", "Patricia Munroe", "Mark J. Caulfield", "Alberto Zanchetti", "Anna F. Dominiczak"], "doi"=>"https://dx.doi.org/10.1371/journal.pgen.1001177.t001", "stats"=>{"downloads"=>0, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Demographic_characteristics_of_the_discovery_case_control_population_/492704", "title"=>"Demographic characteristics of the discovery case control population.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2010-10-28 00:45:04"}
  • {"files"=>["https://ndownloader.figshare.com/files/821745"], "description"=>"<p>A: Forest plot of association analysis unadjusted for any covariates −21,466 cases and 18,240 controls. B: Forest plot of association analysis adjusted age, age<sup>2</sup>, sex and BMI −21,466 cases and 18,240 controls. C: Forest plot of association analysis in the cohorts where eGFR was available and adjusted for age, age<sup>2</sup>, sex, BMI −7427 controls and 5739 cases. D: Forest plot of association analysis in the cohorts where eGFR was available and adjusted for age, age<sup>2</sup>, sex, BMI and eGFR −7427 controls and 5739 cases.</p>", "links"=>[], "tags"=>["plots", "rs13333226", "hypertension", "stratification", "was", "applied", "components"], "article_id"=>492001, "categories"=>["Genetics", "Computational Biology"], "users"=>["Sandosh Padmanabhan", "Olle Melander", "Toby Johnson", "Anna Maria Di Blasio", "Wai K. Lee", "Davide Gentilini", "Claire E. Hastie", "Cristina Menni", "Maria Cristina Monti", "Christian Delles", "Stewart Laing", "Barbara Corso", "Gerjan Navis", "Arjan J. Kwakernaak", "Pim van der Harst", "Murielle Bochud", "Marc Maillard", "Michel Burnier", "Thomas Hedner", "Sverre Kjeldsen", "Björn Wahlstrand", "Marketa Sjögren", "Cristiano Fava", "Martina Montagnana", "Elisa Danese", "Ole Torffvit", "Bo Hedblad", "Harold Snieder", "John M. C. Connell", "Morris Brown", "Nilesh J. Samani", "Martin Farrall", "Giancarlo Cesana", "Giuseppe Mancia", "Stefano Signorini", "Guido Grassi", "Susana Eyheramendy", "H. Erich Wichmann", "Maris Laan", "David P. Strachan", "Peter Sever", "Denis Colm Shields", "Alice Stanton", "Peter Vollenweider", "Alexander Teumer", "Henry Völzke", "Rainer Rettig", "Christopher Newton-Cheh", "Pankaj Arora", "Feng Zhang", "Nicole Soranzo", "Timothy D. Spector", "Gavin Lucas", "Sekar Kathiresan", "David S. Siscovick", "Jian'an Luan", "Ruth J. F. Loos", "Nicholas J. Wareham", "Brenda W. Penninx", "Ilja M. Nolte", "Martin McBride", "William H. Miller", "Stuart A. Nicklin", "Andrew H. Baker", "Delyth Graham", "Robert A. McDonald", "Jill P. Pell", "Naveed Sattar", "Paul Welsh", "Patricia Munroe", "Mark J. Caulfield", "Alberto Zanchetti", "Anna F. Dominiczak"], "doi"=>"https://dx.doi.org/10.1371/journal.pgen.1001177.g004", "stats"=>{"downloads"=>1, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Forest_Plots_of_association_with_rs13333226_and_hypertension_adjustment_for_population_stratification_was_applied_using_principal_components_as_appropriate_for_each_cohort_/492001", "title"=>"Forest Plots of association with rs13333226 and hypertension (adjustment for population stratification was applied using principal components as appropriate for each cohort).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2010-10-28 00:33:21"}
  • {"files"=>["https://ndownloader.figshare.com/files/821129"], "description"=>"<p>Manhattan plot of genomewide –log<sub>10</sub>(p-value) from association analysis of BP extremes in the discovery sample.</p>", "links"=>[], "tags"=>["genomewide", "bp", "extremes"], "article_id"=>491395, "categories"=>["Genetics", "Computational Biology"], "users"=>["Sandosh Padmanabhan", "Olle Melander", "Toby Johnson", "Anna Maria Di Blasio", "Wai K. Lee", "Davide Gentilini", "Claire E. Hastie", "Cristina Menni", "Maria Cristina Monti", "Christian Delles", "Stewart Laing", "Barbara Corso", "Gerjan Navis", "Arjan J. Kwakernaak", "Pim van der Harst", "Murielle Bochud", "Marc Maillard", "Michel Burnier", "Thomas Hedner", "Sverre Kjeldsen", "Björn Wahlstrand", "Marketa Sjögren", "Cristiano Fava", "Martina Montagnana", "Elisa Danese", "Ole Torffvit", "Bo Hedblad", "Harold Snieder", "John M. C. Connell", "Morris Brown", "Nilesh J. Samani", "Martin Farrall", "Giancarlo Cesana", "Giuseppe Mancia", "Stefano Signorini", "Guido Grassi", "Susana Eyheramendy", "H. Erich Wichmann", "Maris Laan", "David P. Strachan", "Peter Sever", "Denis Colm Shields", "Alice Stanton", "Peter Vollenweider", "Alexander Teumer", "Henry Völzke", "Rainer Rettig", "Christopher Newton-Cheh", "Pankaj Arora", "Feng Zhang", "Nicole Soranzo", "Timothy D. Spector", "Gavin Lucas", "Sekar Kathiresan", "David S. Siscovick", "Jian'an Luan", "Ruth J. F. Loos", "Nicholas J. Wareham", "Brenda W. Penninx", "Ilja M. Nolte", "Martin McBride", "William H. Miller", "Stuart A. Nicklin", "Andrew H. Baker", "Delyth Graham", "Robert A. McDonald", "Jill P. Pell", "Naveed Sattar", "Paul Welsh", "Patricia Munroe", "Mark J. Caulfield", "Alberto Zanchetti", "Anna F. Dominiczak"], "doi"=>"https://dx.doi.org/10.1371/journal.pgen.1001177.g001", "stats"=>{"downloads"=>1, "page_views"=>12, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Manhattan_plot_of_genomewide_log_10_p_value_from_association_analysis_of_BP_extremes_in_the_discovery_sample_/491395", "title"=>"Manhattan plot of genomewide –log<sub>10</sub>(p-value) from association analysis of BP extremes in the discovery sample.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2010-10-28 00:23:15"}
  • {"files"=>["https://ndownloader.figshare.com/files/409583", "https://ndownloader.figshare.com/files/409607", "https://ndownloader.figshare.com/files/409630", "https://ndownloader.figshare.com/files/409671", "https://ndownloader.figshare.com/files/409749"], "description"=>"<div><p>Hypertension is a heritable and major contributor to the global burden of disease. The sum of rare and common genetic variants robustly identified so far explain only 1%–2% of the population variation in BP and hypertension. This suggests the existence of more undiscovered common variants. We conducted a genome-wide association study in 1,621 hypertensive cases and 1,699 controls and follow-up validation analyses in 19,845 cases and 16,541 controls using an extreme case-control design. We identified a locus on chromosome 16 in the 5′ region of Uromodulin (<em>UMOD</em>; rs13333226, combined P value of 3.6×10<sup>−11</sup>). The minor G allele is associated with a lower risk of hypertension (OR [95%CI]: 0.87 [0.84–0.91]), reduced urinary uromodulin excretion, better renal function; and each copy of the G allele is associated with a 7.7% reduction in risk of CVD events after adjusting for age, sex, BMI, and smoking status (H.R. = 0.923, 95% CI 0.860–0.991; p = 0.027). In a subset of 13,446 individuals with estimated glomerular filtration rate (eGFR) measurements, we show that rs13333226 is independently associated with hypertension (unadjusted for eGFR: 0.89 [0.83–0.96], p = 0.004; after eGFR adjustment: 0.89 [0.83–0.96], p = 0.003). In clinical functional studies, we also consistently show the minor G allele is associated with lower urinary uromodulin excretion. The exclusive expression of uromodulin in the thick portion of the ascending limb of Henle suggests a putative role of this variant in hypertension through an effect on sodium homeostasis. The newly discovered <em>UMOD</em> locus for hypertension has the potential to give new insights into the role of uromodulin in BP regulation and to identify novel drugable targets for reducing cardiovascular risk.</p></div>", "links"=>[], "tags"=>["genome-wide", "extremes", "identifies", "variant", "hypertension"], "article_id"=>140868, "categories"=>["Genetics", "Biological Sciences"], "users"=>["Sandosh Padmanabhan", "Olle Melander", "Toby Johnson", "Anna Maria Di Blasio", "Wai K. Lee", "Davide Gentilini", "Claire E. Hastie", "Cristina Menni", "Maria Cristina Monti", "Christian Delles", "Stewart Laing", "Barbara Corso", "Gerjan Navis", "Arjan J. Kwakernaak", "Pim van der Harst", "Murielle Bochud", "Marc Maillard", "Michel Burnier", "Thomas Hedner", "Sverre Kjeldsen", "Björn Wahlstrand", "Marketa Sjögren", "Cristiano Fava", "Martina Montagnana", "Elisa Danese", "Ole Torffvit", "Bo Hedblad", "Harold Snieder", "John M. C. Connell", "Morris Brown", "Nilesh J. Samani", "Martin Farrall", "Giancarlo Cesana", "Giuseppe Mancia", "Stefano Signorini", "Guido Grassi", "Susana Eyheramendy", "H. Erich Wichmann", "Maris Laan", "David P. Strachan", "Peter Sever", "Denis Colm Shields", "Alice Stanton", "Peter Vollenweider", "Alexander Teumer", "Henry Völzke", "Rainer Rettig", "Christopher Newton-Cheh", "Pankaj Arora", "Feng Zhang", "Nicole Soranzo", "Timothy D. Spector", "Gavin Lucas", "Sekar Kathiresan", "David S. Siscovick", "Jian'an Luan", "Ruth J. F. Loos", "Nicholas J. Wareham", "Brenda W. Penninx", "Ilja M. Nolte", "Martin McBride", "William H. Miller", "Stuart A. Nicklin", "Andrew H. Baker", "Delyth Graham", "Robert A. McDonald", "Jill P. Pell", "Naveed Sattar", "Paul Welsh", "Patricia Munroe", "Mark J. Caulfield", "Alberto Zanchetti", "Anna F. Dominiczak"], "doi"=>["https://dx.doi.org/10.1371/journal.pgen.1001177.s001", "https://dx.doi.org/10.1371/journal.pgen.1001177.s002", "https://dx.doi.org/10.1371/journal.pgen.1001177.s003", "https://dx.doi.org/10.1371/journal.pgen.1001177.s004", "https://dx.doi.org/10.1371/journal.pgen.1001177.s005"], "stats"=>{"downloads"=>20, "page_views"=>18, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Genome_Wide_Association_Study_of_Blood_Pressure_Extremes_Identifies_Variant_near_UMOD_Associated_with_Hypertension/140868", "title"=>"Genome-Wide Association Study of Blood Pressure Extremes Identifies Variant near <em>UMOD</em> Associated with Hypertension", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2010-10-28 00:14:28"}
  • {"files"=>["https://ndownloader.figshare.com/files/821322"], "description"=>"<p>Quantile-Quantile plot of observed versus expected p-value distributions in the discovery sample.</p>", "links"=>[], "tags"=>["observed", "p-value", "distributions"], "article_id"=>491591, "categories"=>["Genetics", "Computational Biology"], "users"=>["Sandosh Padmanabhan", "Olle Melander", "Toby Johnson", "Anna Maria Di Blasio", "Wai K. Lee", "Davide Gentilini", "Claire E. Hastie", "Cristina Menni", "Maria Cristina Monti", "Christian Delles", "Stewart Laing", "Barbara Corso", "Gerjan Navis", "Arjan J. Kwakernaak", "Pim van der Harst", "Murielle Bochud", "Marc Maillard", "Michel Burnier", "Thomas Hedner", "Sverre Kjeldsen", "Björn Wahlstrand", "Marketa Sjögren", "Cristiano Fava", "Martina Montagnana", "Elisa Danese", "Ole Torffvit", "Bo Hedblad", "Harold Snieder", "John M. C. Connell", "Morris Brown", "Nilesh J. Samani", "Martin Farrall", "Giancarlo Cesana", "Giuseppe Mancia", "Stefano Signorini", "Guido Grassi", "Susana Eyheramendy", "H. Erich Wichmann", "Maris Laan", "David P. Strachan", "Peter Sever", "Denis Colm Shields", "Alice Stanton", "Peter Vollenweider", "Alexander Teumer", "Henry Völzke", "Rainer Rettig", "Christopher Newton-Cheh", "Pankaj Arora", "Feng Zhang", "Nicole Soranzo", "Timothy D. Spector", "Gavin Lucas", "Sekar Kathiresan", "David S. Siscovick", "Jian'an Luan", "Ruth J. F. Loos", "Nicholas J. Wareham", "Brenda W. Penninx", "Ilja M. Nolte", "Martin McBride", "William H. Miller", "Stuart A. Nicklin", "Andrew H. Baker", "Delyth Graham", "Robert A. McDonald", "Jill P. Pell", "Naveed Sattar", "Paul Welsh", "Patricia Munroe", "Mark J. Caulfield", "Alberto Zanchetti", "Anna F. Dominiczak"], "doi"=>"https://dx.doi.org/10.1371/journal.pgen.1001177.g002", "stats"=>{"downloads"=>0, "page_views"=>10, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Quantile_Quantile_plot_of_observed_versus_expected_p_value_distributions_in_the_discovery_sample_/491591", "title"=>"Quantile-Quantile plot of observed versus expected p-value distributions in the discovery sample.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2010-10-28 00:26:31"}
  • {"files"=>["https://ndownloader.figshare.com/files/822590"], "description"=>"<p>P value of the meta-analysis Q test for heterogeneity = 0.87.</p>", "links"=>[], "tags"=>["meta-analysis", "rs13333226", "htn"], "article_id"=>492840, "categories"=>["Genetics", "Computational Biology"], "users"=>["Sandosh Padmanabhan", "Olle Melander", "Toby Johnson", "Anna Maria Di Blasio", "Wai K. Lee", "Davide Gentilini", "Claire E. Hastie", "Cristina Menni", "Maria Cristina Monti", "Christian Delles", "Stewart Laing", "Barbara Corso", "Gerjan Navis", "Arjan J. Kwakernaak", "Pim van der Harst", "Murielle Bochud", "Marc Maillard", "Michel Burnier", "Thomas Hedner", "Sverre Kjeldsen", "Björn Wahlstrand", "Marketa Sjögren", "Cristiano Fava", "Martina Montagnana", "Elisa Danese", "Ole Torffvit", "Bo Hedblad", "Harold Snieder", "John M. C. Connell", "Morris Brown", "Nilesh J. Samani", "Martin Farrall", "Giancarlo Cesana", "Giuseppe Mancia", "Stefano Signorini", "Guido Grassi", "Susana Eyheramendy", "H. Erich Wichmann", "Maris Laan", "David P. Strachan", "Peter Sever", "Denis Colm Shields", "Alice Stanton", "Peter Vollenweider", "Alexander Teumer", "Henry Völzke", "Rainer Rettig", "Christopher Newton-Cheh", "Pankaj Arora", "Feng Zhang", "Nicole Soranzo", "Timothy D. Spector", "Gavin Lucas", "Sekar Kathiresan", "David S. Siscovick", "Jian'an Luan", "Ruth J. F. Loos", "Nicholas J. Wareham", "Brenda W. Penninx", "Ilja M. Nolte", "Martin McBride", "William H. Miller", "Stuart A. Nicklin", "Andrew H. Baker", "Delyth Graham", "Robert A. McDonald", "Jill P. Pell", "Naveed Sattar", "Paul Welsh", "Patricia Munroe", "Mark J. Caulfield", "Alberto Zanchetti", "Anna F. Dominiczak"], "doi"=>"https://dx.doi.org/10.1371/journal.pgen.1001177.t003", "stats"=>{"downloads"=>1, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Results_from_the_meta_analysis_of_rs13333226_and_HTN_before_and_after_adjustment_for_eGFR_/492840", "title"=>"Results from the meta-analysis of rs13333226 and HTN before and after adjustment for eGFR.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2010-10-28 00:47:20"}
  • {"files"=>["https://ndownloader.figshare.com/files/822162"], "description"=>"<p>Univariate association analysis of rs13333226 in 256 hypertensive patients from the BRIGHT study.</p>", "links"=>[], "tags"=>["rs13333226", "256", "hypertensive", "patients"], "article_id"=>492426, "categories"=>["Genetics", "Computational Biology"], "users"=>["Sandosh Padmanabhan", "Olle Melander", "Toby Johnson", "Anna Maria Di Blasio", "Wai K. Lee", "Davide Gentilini", "Claire E. Hastie", "Cristina Menni", "Maria Cristina Monti", "Christian Delles", "Stewart Laing", "Barbara Corso", "Gerjan Navis", "Arjan J. Kwakernaak", "Pim van der Harst", "Murielle Bochud", "Marc Maillard", "Michel Burnier", "Thomas Hedner", "Sverre Kjeldsen", "Björn Wahlstrand", "Marketa Sjögren", "Cristiano Fava", "Martina Montagnana", "Elisa Danese", "Ole Torffvit", "Bo Hedblad", "Harold Snieder", "John M. C. Connell", "Morris Brown", "Nilesh J. Samani", "Martin Farrall", "Giancarlo Cesana", "Giuseppe Mancia", "Stefano Signorini", "Guido Grassi", "Susana Eyheramendy", "H. Erich Wichmann", "Maris Laan", "David P. Strachan", "Peter Sever", "Denis Colm Shields", "Alice Stanton", "Peter Vollenweider", "Alexander Teumer", "Henry Völzke", "Rainer Rettig", "Christopher Newton-Cheh", "Pankaj Arora", "Feng Zhang", "Nicole Soranzo", "Timothy D. Spector", "Gavin Lucas", "Sekar Kathiresan", "David S. Siscovick", "Jian'an Luan", "Ruth J. F. Loos", "Nicholas J. Wareham", "Brenda W. Penninx", "Ilja M. Nolte", "Martin McBride", "William H. Miller", "Stuart A. Nicklin", "Andrew H. Baker", "Delyth Graham", "Robert A. McDonald", "Jill P. Pell", "Naveed Sattar", "Paul Welsh", "Patricia Munroe", "Mark J. Caulfield", "Alberto Zanchetti", "Anna F. Dominiczak"], "doi"=>"https://dx.doi.org/10.1371/journal.pgen.1001177.t004", "stats"=>{"downloads"=>1, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Univariate_association_analysis_of_rs13333226_in_256_hypertensive_patients_from_the_BRIGHT_study_/492426", "title"=>"Univariate association analysis of rs13333226 in 256 hypertensive patients from the BRIGHT study.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2010-10-28 00:40:26"}
  • {"files"=>["https://ndownloader.figshare.com/files/821543"], "description"=>"<p>Association plot of the genomic region around rs13333226 showing both typed and imputed SNPs with location of genes and recombination rate.</p>", "links"=>[], "tags"=>["genomic", "rs13333226", "typed", "imputed", "snps", "genes", "recombination"], "article_id"=>491796, "categories"=>["Genetics", "Computational Biology"], "users"=>["Sandosh Padmanabhan", "Olle Melander", "Toby Johnson", "Anna Maria Di Blasio", "Wai K. Lee", "Davide Gentilini", "Claire E. Hastie", "Cristina Menni", "Maria Cristina Monti", "Christian Delles", "Stewart Laing", "Barbara Corso", "Gerjan Navis", "Arjan J. Kwakernaak", "Pim van der Harst", "Murielle Bochud", "Marc Maillard", "Michel Burnier", "Thomas Hedner", "Sverre Kjeldsen", "Björn Wahlstrand", "Marketa Sjögren", "Cristiano Fava", "Martina Montagnana", "Elisa Danese", "Ole Torffvit", "Bo Hedblad", "Harold Snieder", "John M. C. Connell", "Morris Brown", "Nilesh J. Samani", "Martin Farrall", "Giancarlo Cesana", "Giuseppe Mancia", "Stefano Signorini", "Guido Grassi", "Susana Eyheramendy", "H. Erich Wichmann", "Maris Laan", "David P. Strachan", "Peter Sever", "Denis Colm Shields", "Alice Stanton", "Peter Vollenweider", "Alexander Teumer", "Henry Völzke", "Rainer Rettig", "Christopher Newton-Cheh", "Pankaj Arora", "Feng Zhang", "Nicole Soranzo", "Timothy D. Spector", "Gavin Lucas", "Sekar Kathiresan", "David S. Siscovick", "Jian'an Luan", "Ruth J. F. Loos", "Nicholas J. Wareham", "Brenda W. Penninx", "Ilja M. Nolte", "Martin McBride", "William H. Miller", "Stuart A. Nicklin", "Andrew H. Baker", "Delyth Graham", "Robert A. McDonald", "Jill P. Pell", "Naveed Sattar", "Paul Welsh", "Patricia Munroe", "Mark J. Caulfield", "Alberto Zanchetti", "Anna F. Dominiczak"], "doi"=>"https://dx.doi.org/10.1371/journal.pgen.1001177.g003", "stats"=>{"downloads"=>2, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Association_plot_of_the_genomic_region_around_rs13333226_showing_both_typed_and_imputed_SNPs_with_location_of_genes_and_recombination_rate_/491796", "title"=>"Association plot of the genomic region around rs13333226 showing both typed and imputed SNPs with location of genes and recombination rate.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2010-10-28 00:29:56"}
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  • {"files"=>["https://ndownloader.figshare.com/files/822723"], "description"=>"<p>Q(unadj/adj)  = P value of the meta-analysis Q test for heterogeneity for the unadjusted and adjusted meta-analysis respectively.</p>", "links"=>[], "tags"=>["meta-analysis", "rs13333226", "htn"], "article_id"=>492986, "categories"=>["Genetics", "Computational Biology"], "users"=>["Sandosh Padmanabhan", "Olle Melander", "Toby Johnson", "Anna Maria Di Blasio", "Wai K. Lee", "Davide Gentilini", "Claire E. Hastie", "Cristina Menni", "Maria Cristina Monti", "Christian Delles", "Stewart Laing", "Barbara Corso", "Gerjan Navis", "Arjan J. Kwakernaak", "Pim van der Harst", "Murielle Bochud", "Marc Maillard", "Michel Burnier", "Thomas Hedner", "Sverre Kjeldsen", "Björn Wahlstrand", "Marketa Sjögren", "Cristiano Fava", "Martina Montagnana", "Elisa Danese", "Ole Torffvit", "Bo Hedblad", "Harold Snieder", "John M. C. Connell", "Morris Brown", "Nilesh J. Samani", "Martin Farrall", "Giancarlo Cesana", "Giuseppe Mancia", "Stefano Signorini", "Guido Grassi", "Susana Eyheramendy", "H. Erich Wichmann", "Maris Laan", "David P. Strachan", "Peter Sever", "Denis Colm Shields", "Alice Stanton", "Peter Vollenweider", "Alexander Teumer", "Henry Völzke", "Rainer Rettig", "Christopher Newton-Cheh", "Pankaj Arora", "Feng Zhang", "Nicole Soranzo", "Timothy D. Spector", "Gavin Lucas", "Sekar Kathiresan", "David S. Siscovick", "Jian'an Luan", "Ruth J. F. Loos", "Nicholas J. Wareham", "Brenda W. Penninx", "Ilja M. Nolte", "Martin McBride", "William H. Miller", "Stuart A. Nicklin", "Andrew H. Baker", "Delyth Graham", "Robert A. McDonald", "Jill P. Pell", "Naveed Sattar", "Paul Welsh", "Patricia Munroe", "Mark J. Caulfield", "Alberto Zanchetti", "Anna F. Dominiczak"], "doi"=>"https://dx.doi.org/10.1371/journal.pgen.1001177.t002", "stats"=>{"downloads"=>1, "page_views"=>17, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Results_from_the_meta_analysis_of_rs13333226_and_HTN_in_discovery_sample_and_after_validation_/492986", "title"=>"Results from the meta-analysis of rs13333226 and HTN in discovery sample and after validation.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2010-10-28 00:49:46"}
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  • {"unique-ip"=>"27", "full-text"=>"31", "pdf"=>"14", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2016", "month"=>"1"}
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  • {"unique-ip"=>"24", "full-text"=>"23", "pdf"=>"10", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"10"}
  • {"unique-ip"=>"25", "full-text"=>"31", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2016", "month"=>"11"}
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  • {"unique-ip"=>"29", "full-text"=>"27", "pdf"=>"18", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"4", "cited-by"=>"0", "year"=>"2018", "month"=>"11"}
  • {"unique-ip"=>"21", "full-text"=>"18", "pdf"=>"10", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"12"}
  • {"unique-ip"=>"13", "full-text"=>"13", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"2"}
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  • {"unique-ip"=>"18", "full-text"=>"17", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"5"}
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Relative Metric

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