Four Novel Loci (19q13, 6q24, 12q24, and 5q14) Influence the Microcirculation In Vivo
Publication Date
October 28, 2010
Journal
PLOS Genetics
Authors
M. Kamran Ikram, Sim Xueling, Richard A. Jensen, Mary Frances Cotch, et al
Volume
6
Issue
10
Pages
e1001184
DOI
https://dx.plos.org/10.1371/journal.pgen.1001184
Publisher URL
http://journals.plos.org/plosgenetics/article?id=10.1371%2Fjournal.pgen.1001184
PubMed
http://www.ncbi.nlm.nih.gov/pubmed/21060863
PubMed Central
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2965750
Europe PMC
http://europepmc.org/abstract/MED/21060863
Web of Science
000283647800015
Scopus
78449249315
Mendeley
http://www.mendeley.com/research/four-novel-loci-19q13-6q24-12q24-5q14-influence-microcirculation-vivo
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Mendeley | Further Information

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M.Amirul", "last_name"=>"Islam", "scopus_author_id"=>"35446440500"}, {"first_name"=>"Jerome I.", "last_name"=>"Rotter", "scopus_author_id"=>"56284453500"}, {"first_name"=>"Annie K.", "last_name"=>"McAuley", "scopus_author_id"=>"36628778600"}, {"first_name"=>"Eric", "last_name"=>"Boerwinkle", "scopus_author_id"=>"7102087489"}, {"first_name"=>"E. Shyong", "last_name"=>"Tai", "scopus_author_id"=>"7005660980"}, {"first_name"=>"Vilmundur", "last_name"=>"Gudnason", "scopus_author_id"=>"7003353432"}, {"first_name"=>"David S.", "last_name"=>"Siscovick", "scopus_author_id"=>"7005419833"}, {"first_name"=>"Johannes R.", "last_name"=>"Vingerling", "scopus_author_id"=>"6603813300"}, {"first_name"=>"Tien Y.", "last_name"=>"Wong", "scopus_author_id"=>"35231271400"}], "year"=>2010, "source"=>"PLoS Genetics", "identifiers"=>{"issn"=>"15537404", "scopus"=>"2-s2.0-78449249315", "sgr"=>"78449249315", "pui"=>"359979469", "isbn"=>"1553-7404 (Electronic)\\r1553-7390 (Linking)", "pmid"=>"21060863", "doi"=>"10.1371/journal.pgen.1001184"}, "id"=>"223aadcf-17ba-36d0-8679-66927912eb74", "abstract"=>"There is increasing evidence that the microcirculation plays an important role in the pathogenesis of cardiovascular diseases. Changes in retinal vascular caliber reflect early microvascular disease and predict incident cardiovascular events. We performed a genome-wide association study to identify genetic variants associated with retinal vascular caliber. We analyzed data from four population-based discovery cohorts with 15,358 unrelated Caucasian individuals, who are members of the Cohort for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium, and replicated findings in four independent Caucasian cohorts (n  =  6,652). All participants had retinal photography and retinal arteriolar and venular caliber measured from computer software. In the discovery cohorts, 179 single nucleotide polymorphisms (SNP) spread across five loci were significantly associated (p<5.0×10(-8)) with retinal venular caliber, but none showed association with arteriolar caliber. Collectively, these five loci explain 1.0%-3.2% of the variation in retinal venular caliber. Four out of these five loci were confirmed in independent replication samples. In the combined analyses, the top SNPs at each locus were: rs2287921 (19q13; p  =  1.61×10(-25), within the RASIP1 locus), rs225717 (6q24; p = 1.25×10(-16), adjacent to the VTA1 and NMBR loci), rs10774625 (12q24; p  =  2.15×10(-13), in the region of ATXN2,SH2B3 and PTPN11 loci), and rs17421627 (5q14; p = 7.32×10(-16), adjacent to the MEF2C locus). In two independent samples, locus 12q24 was also associated with coronary heart disease and hypertension. Our population-based genome-wide association study demonstrates four novel loci associated with retinal venular caliber, an endophenotype of the microcirculation associated with clinical cardiovascular disease. These data provide further insights into the contribution and biological mechanisms of microcirculatory changes that underlie cardiovascular disease.", "link"=>"http://www.mendeley.com/research/four-novel-loci-19q13-6q24-12q24-5q14-influence-microcirculation-vivo", "reader_count"=>85, "reader_count_by_academic_status"=>{"Unspecified"=>5, "Professor > Associate Professor"=>8, "Researcher"=>15, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>19, "Student > Postgraduate"=>3, "Student > Master"=>15, "Other"=>3, "Student > Bachelor"=>6, "Lecturer"=>1, "Lecturer > Senior Lecturer"=>1, "Professor"=>7}, "reader_count_by_user_role"=>{"Unspecified"=>5, "Professor > Associate Professor"=>8, "Researcher"=>15, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>19, "Student > Postgraduate"=>3, "Student > Master"=>15, "Other"=>3, "Student > Bachelor"=>6, "Lecturer"=>1, "Lecturer > Senior Lecturer"=>1, "Professor"=>7}, "reader_count_by_subject_area"=>{"Unspecified"=>6, "Biochemistry, Genetics and Molecular Biology"=>7, "Mathematics"=>3, "Agricultural and Biological Sciences"=>25, "Medicine and Dentistry"=>34, "Neuroscience"=>1, "Physics and Astronomy"=>1, "Psychology"=>1, "Computer Science"=>5, "Immunology and Microbiology"=>1, "Linguistics"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>34}, "Neuroscience"=>{"Neuroscience"=>1}, "Physics and Astronomy"=>{"Physics and Astronomy"=>1}, "Psychology"=>{"Psychology"=>1}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>25}, "Computer Science"=>{"Computer Science"=>5}, "Linguistics"=>{"Linguistics"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>7}, "Mathematics"=>{"Mathematics"=>3}, "Unspecified"=>{"Unspecified"=>6}}, "reader_count_by_country"=>{"United Kingdom"=>2, "Australia"=>1, "Switzerland"=>1, "Germany"=>1, "Iceland"=>1}, "group_count"=>1}

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/821863"], "description"=>"<p>A combined regional association plot showing p-values from CHARGE for the 10 SNPs on 12q24 for retinal venular caliber and from WTCCC for coronary artery disease.</p>", "links"=>[], "tags"=>["p-values", "10", "snps", "12q24", "retinal", "venular", "caliber", "wtccc", "coronary", "artery"], "article_id"=>492130, "categories"=>["Medicine", "Genetics"], "users"=>["M. Kamran Ikram", "Sim Xueling", "Richard A. Jensen", "Mary Frances Cotch", "Alex W. Hewitt", "M. Arfan Ikram", "Jie Jin Wang", "Ronald Klein", "Barbara E. K. Klein", "Monique M. B. Breteler", "Ning Cheung", "Gerald Liew", "Paul Mitchell", "Andre G. Uitterlinden", "Fernando Rivadeneira", "Albert Hofman", "Paulus T. V. M. de Jong", "Cornelia M. van Duijn", "Linda Kao", "Ching-Yu Cheng", "Albert Vernon Smith", "Nicole L. Glazer", "Thomas Lumley", "Barbara McKnight", "Bruce M. Psaty", "Fridbert Jonasson", "Gudny Eiriksdottir", "Thor Aspelund", "Tamara B. Harris", "Lenore J. Launer", "Kent D. Taylor", "Xiaohui Li", "Sudha K. Iyengar", "Quansheng Xi", "Theru A. Sivakumaran", "David A. Mackey", "Stuart Macgregor", "Nicholas G. Martin", "Terri L. Young", "Josh C. Bis", "Kerri L. Wiggins", "Susan R. Heckbert", "Christopher J. Hammond", "Toby Andrew", "Samantha Fahy", "John Attia", "Elizabeth G. Holliday", "Rodney J. Scott", "F. M. Amirul Islam", "Jerome I. Rotter", "Annie K. McAuley", "Eric Boerwinkle", "E. Shyong Tai", "Vilmundur Gudnason", "David S. Siscovick", "Johannes R. Vingerling", "Tien Y. Wong"], "doi"=>"https://dx.doi.org/10.1371/journal.pgen.1001184.g003", "stats"=>{"downloads"=>0, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_A_combined_regional_association_plot_showing_p_values_from_CHARGE_for_the_10_SNPs_on_12q24_for_retinal_venular_caliber_and_from_WTCCC_for_coronary_artery_disease_/492130", "title"=>"A combined regional association plot showing p-values from CHARGE for the 10 SNPs on 12q24 for retinal venular caliber and from WTCCC for coronary artery disease.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2010-10-28 00:35:30"}
  • {"files"=>["https://ndownloader.figshare.com/files/409532", "https://ndownloader.figshare.com/files/409554", "https://ndownloader.figshare.com/files/409590"], "description"=>"<div><p>There is increasing evidence that the microcirculation plays an important role in the pathogenesis of cardiovascular diseases. Changes in retinal vascular caliber reflect early microvascular disease and predict incident cardiovascular events. We performed a genome-wide association study to identify genetic variants associated with retinal vascular caliber. We analyzed data from four population-based discovery cohorts with 15,358 unrelated Caucasian individuals, who are members of the Cohort for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium, and replicated findings in four independent Caucasian cohorts (n = 6,652). All participants had retinal photography and retinal arteriolar and venular caliber measured from computer software. In the discovery cohorts, 179 single nucleotide polymorphisms (SNP) spread across five loci were significantly associated (p<5.0×10<sup>−8</sup>) with retinal venular caliber, but none showed association with arteriolar caliber. Collectively, these five loci explain 1.0%–3.2% of the variation in retinal venular caliber. Four out of these five loci were confirmed in independent replication samples. In the combined analyses, the top SNPs at each locus were: rs2287921 (19q13; p = 1.61×10<sup>−25</sup>, within the <em>RASIP1</em> locus), rs225717 (6q24; p = 1.25×10<sup>−16</sup>, adjacent to the <em>VTA1</em> and <em>NMBR</em> loci), rs10774625 (12q24; p = 2.15×10<sup>−13</sup>, in the region of <em>ATXN2,SH2B3</em> and <em>PTPN11</em> loci), and rs17421627 (5q14; p = 7.32×10<sup>−16</sup>, adjacent to the <em>MEF2C</em> locus). In two independent samples, locus 12q24 was also associated with coronary heart disease and hypertension. Our population-based genome-wide association study demonstrates four novel loci associated with retinal venular caliber, an endophenotype of the microcirculation associated with clinical cardiovascular disease. These data provide further insights into the contribution and biological mechanisms of microcirculatory changes that underlie cardiovascular disease.</p></div>", "links"=>[], "tags"=>["loci", "microcirculation"], "article_id"=>140872, "categories"=>["Medicine", "Genetics"], "users"=>["M. Kamran Ikram", "Sim Xueling", "Richard A. Jensen", "Mary Frances Cotch", "Alex W. Hewitt", "M. Arfan Ikram", "Jie Jin Wang", "Ronald Klein", "Barbara E. K. Klein", "Monique M. B. Breteler", "Ning Cheung", "Gerald Liew", "Paul Mitchell", "Andre G. Uitterlinden", "Fernando Rivadeneira", "Albert Hofman", "Paulus T. V. M. de Jong", "Cornelia M. van Duijn", "Linda Kao", "Ching-Yu Cheng", "Albert Vernon Smith", "Nicole L. Glazer", "Thomas Lumley", "Barbara McKnight", "Bruce M. Psaty", "Fridbert Jonasson", "Gudny Eiriksdottir", "Thor Aspelund", "Tamara B. Harris", "Lenore J. Launer", "Kent D. Taylor", "Xiaohui Li", "Sudha K. Iyengar", "Quansheng Xi", "Theru A. Sivakumaran", "David A. Mackey", "Stuart Macgregor", "Nicholas G. Martin", "Terri L. Young", "Josh C. Bis", "Kerri L. Wiggins", "Susan R. Heckbert", "Christopher J. Hammond", "Toby Andrew", "Samantha Fahy", "John Attia", "Elizabeth G. Holliday", "Rodney J. Scott", "F. M. Amirul Islam", "Jerome I. Rotter", "Annie K. McAuley", "Eric Boerwinkle", "E. Shyong Tai", "Vilmundur Gudnason", "David S. Siscovick", "Johannes R. Vingerling", "Tien Y. Wong"], "doi"=>["https://dx.doi.org/10.1371/journal.pgen.1001184.s001", "https://dx.doi.org/10.1371/journal.pgen.1001184.s002", "https://dx.doi.org/10.1371/journal.pgen.1001184.s003"], "stats"=>{"downloads"=>38, "page_views"=>30, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Four_Novel_Loci_19q13_6q24_12q24_and_5q14_Influence_the_Microcirculation_In_Vivo_/140872", "title"=>"Four Novel Loci (19q13, 6q24, 12q24, and 5q14) Influence the Microcirculation <em>In Vivo</em>", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2010-10-28 00:14:32"}
  • {"files"=>["https://ndownloader.figshare.com/files/822168"], "description"=>"<p>CHARGE: Cohorts for Heart and Aging Research in Genomic Epidemiology consortium; BDES: Beaver Dam Eye Study; BMES: Blue Mountains Eye Study; SNP: single nucleotide polymorphism; Beta: Change in retinal venular caliber for each copy of the minor allele; SE: standard error.</p>", "links"=>[], "tags"=>["loci", "retinal", "venular", "caliber"], "article_id"=>492457, "categories"=>["Medicine", "Genetics"], "users"=>["M. Kamran Ikram", "Sim Xueling", "Richard A. Jensen", "Mary Frances Cotch", "Alex W. Hewitt", "M. Arfan Ikram", "Jie Jin Wang", "Ronald Klein", "Barbara E. K. Klein", "Monique M. B. Breteler", "Ning Cheung", "Gerald Liew", "Paul Mitchell", "Andre G. Uitterlinden", "Fernando Rivadeneira", "Albert Hofman", "Paulus T. V. M. de Jong", "Cornelia M. van Duijn", "Linda Kao", "Ching-Yu Cheng", "Albert Vernon Smith", "Nicole L. Glazer", "Thomas Lumley", "Barbara McKnight", "Bruce M. Psaty", "Fridbert Jonasson", "Gudny Eiriksdottir", "Thor Aspelund", "Tamara B. Harris", "Lenore J. Launer", "Kent D. Taylor", "Xiaohui Li", "Sudha K. Iyengar", "Quansheng Xi", "Theru A. Sivakumaran", "David A. Mackey", "Stuart Macgregor", "Nicholas G. Martin", "Terri L. Young", "Josh C. Bis", "Kerri L. Wiggins", "Susan R. Heckbert", "Christopher J. Hammond", "Toby Andrew", "Samantha Fahy", "John Attia", "Elizabeth G. Holliday", "Rodney J. Scott", "F. M. Amirul Islam", "Jerome I. Rotter", "Annie K. McAuley", "Eric Boerwinkle", "E. Shyong Tai", "Vilmundur Gudnason", "David S. Siscovick", "Johannes R. Vingerling", "Tien Y. Wong"], "doi"=>"https://dx.doi.org/10.1371/journal.pgen.1001184.t003", "stats"=>{"downloads"=>0, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Results_for_the_five_loci_associated_with_retinal_venular_caliber_for_the_discovery_replication_and_combined_cohorts_/492457", "title"=>"Results for the five loci associated with retinal venular caliber for the discovery, replication, and combined cohorts.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2010-10-28 00:40:57"}
  • {"files"=>["https://ndownloader.figshare.com/files/822286"], "description"=>"<p>CHARGE: Cohorts for Heart and Aging Research in Genomic Epidemiology consortium; AGES: Age Gene/Environment Susceptibility – Reykjavik Study; ARIC: Atherosclerosis Risk in Communities Study; CHS: Cardiovascular Health Study; RS: Rotterdam Study; SNP: single nucleotide polymorphism; MAF: minor allele frequency; Beta: Change in retinal venular calibre for each copy of the minor allele; SE: standard error.</p>", "links"=>[], "tags"=>["loci", "retinal", "venular", "caliber", "cohorts"], "article_id"=>492578, "categories"=>["Medicine", "Genetics"], "users"=>["M. Kamran Ikram", "Sim Xueling", "Richard A. Jensen", "Mary Frances Cotch", "Alex W. Hewitt", "M. Arfan Ikram", "Jie Jin Wang", "Ronald Klein", "Barbara E. K. Klein", "Monique M. B. Breteler", "Ning Cheung", "Gerald Liew", "Paul Mitchell", "Andre G. Uitterlinden", "Fernando Rivadeneira", "Albert Hofman", "Paulus T. V. M. de Jong", "Cornelia M. van Duijn", "Linda Kao", "Ching-Yu Cheng", "Albert Vernon Smith", "Nicole L. Glazer", "Thomas Lumley", "Barbara McKnight", "Bruce M. Psaty", "Fridbert Jonasson", "Gudny Eiriksdottir", "Thor Aspelund", "Tamara B. Harris", "Lenore J. Launer", "Kent D. Taylor", "Xiaohui Li", "Sudha K. Iyengar", "Quansheng Xi", "Theru A. Sivakumaran", "David A. Mackey", "Stuart Macgregor", "Nicholas G. Martin", "Terri L. Young", "Josh C. Bis", "Kerri L. Wiggins", "Susan R. Heckbert", "Christopher J. Hammond", "Toby Andrew", "Samantha Fahy", "John Attia", "Elizabeth G. Holliday", "Rodney J. Scott", "F. M. Amirul Islam", "Jerome I. Rotter", "Annie K. McAuley", "Eric Boerwinkle", "E. Shyong Tai", "Vilmundur Gudnason", "David S. Siscovick", "Johannes R. Vingerling", "Tien Y. Wong"], "doi"=>"https://dx.doi.org/10.1371/journal.pgen.1001184.t002", "stats"=>{"downloads"=>0, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Results_for_the_five_loci_associated_p_8722_8_with_retinal_venular_caliber_in_the_discovery_cohorts_both_combined_and_individually_/492578", "title"=>"Results for the five loci associated (p<5.0×10<sup>−8</sup>) with retinal venular caliber in the discovery cohorts both combined and individually.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2010-10-28 00:42:58"}
  • {"files"=>["https://ndownloader.figshare.com/files/822404"], "description"=>"<p>AGES: Age Gene/Environment Susceptibility – Reykjavik Study; ARIC: Atherosclerosis Risk in Communities Study; CHS: Cardiovascular Health Study; RS: Rotterdam Study; BDES: Beaver Dam Eye Study; BMES: Blue Mountains Eye Study; CRAE: central retinal arteriolar equivalent; CRVE: central retinal venular equivalent; SD: standard deviation; N/A Not available.</p>", "links"=>[], "tags"=>["characteristics", "replication"], "article_id"=>492687, "categories"=>["Medicine", "Genetics"], "users"=>["M. Kamran Ikram", "Sim Xueling", "Richard A. Jensen", "Mary Frances Cotch", "Alex W. Hewitt", "M. Arfan Ikram", "Jie Jin Wang", "Ronald Klein", "Barbara E. K. Klein", "Monique M. B. Breteler", "Ning Cheung", "Gerald Liew", "Paul Mitchell", "Andre G. Uitterlinden", "Fernando Rivadeneira", "Albert Hofman", "Paulus T. V. M. de Jong", "Cornelia M. van Duijn", "Linda Kao", "Ching-Yu Cheng", "Albert Vernon Smith", "Nicole L. Glazer", "Thomas Lumley", "Barbara McKnight", "Bruce M. Psaty", "Fridbert Jonasson", "Gudny Eiriksdottir", "Thor Aspelund", "Tamara B. Harris", "Lenore J. Launer", "Kent D. Taylor", "Xiaohui Li", "Sudha K. Iyengar", "Quansheng Xi", "Theru A. Sivakumaran", "David A. Mackey", "Stuart Macgregor", "Nicholas G. Martin", "Terri L. Young", "Josh C. Bis", "Kerri L. Wiggins", "Susan R. Heckbert", "Christopher J. Hammond", "Toby Andrew", "Samantha Fahy", "John Attia", "Elizabeth G. Holliday", "Rodney J. Scott", "F. M. Amirul Islam", "Jerome I. Rotter", "Annie K. McAuley", "Eric Boerwinkle", "E. Shyong Tai", "Vilmundur Gudnason", "David S. Siscovick", "Johannes R. Vingerling", "Tien Y. Wong"], "doi"=>"https://dx.doi.org/10.1371/journal.pgen.1001184.t001", "stats"=>{"downloads"=>0, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Baseline_characteristics_of_both_the_discovery_and_replication_cohorts_/492687", "title"=>"Baseline characteristics of both the discovery and replication cohorts.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2010-10-28 00:44:47"}
  • {"files"=>["https://ndownloader.figshare.com/files/822054"], "description"=>"<p>CHARGE: Cohort for Heart and Aging Research in Genomic Epidemiology Consortium CRVE: central retinal venular equivalent (CRVE), SE: standard error; WTCCC: Wellcome Trust Case Control Consortium; CAD: coronary artery disease; HVH: Heart and Vascular Health Study; MI: myocardial infarction; Global BPgen: Global Blood Pressure Genetics Consortium; HTN: hypertension; DIAGRAM+: Diabetes Genetics Replication and Meta-analysis+; DM: diabetes mellitus; M.A.: Minor allele within CHARGE; OR: odds ratio (with corresponding 95% confidence interval) per copy of the minor allele.</p>", "links"=>[], "tags"=>["loci", "cardiovascular"], "article_id"=>492337, "categories"=>["Medicine", "Genetics"], "users"=>["M. Kamran Ikram", "Sim Xueling", "Richard A. Jensen", "Mary Frances Cotch", "Alex W. Hewitt", "M. Arfan Ikram", "Jie Jin Wang", "Ronald Klein", "Barbara E. K. Klein", "Monique M. B. Breteler", "Ning Cheung", "Gerald Liew", "Paul Mitchell", "Andre G. Uitterlinden", "Fernando Rivadeneira", "Albert Hofman", "Paulus T. V. M. de Jong", "Cornelia M. van Duijn", "Linda Kao", "Ching-Yu Cheng", "Albert Vernon Smith", "Nicole L. Glazer", "Thomas Lumley", "Barbara McKnight", "Bruce M. Psaty", "Fridbert Jonasson", "Gudny Eiriksdottir", "Thor Aspelund", "Tamara B. Harris", "Lenore J. Launer", "Kent D. Taylor", "Xiaohui Li", "Sudha K. Iyengar", "Quansheng Xi", "Theru A. Sivakumaran", "David A. Mackey", "Stuart Macgregor", "Nicholas G. Martin", "Terri L. Young", "Josh C. Bis", "Kerri L. Wiggins", "Susan R. Heckbert", "Christopher J. Hammond", "Toby Andrew", "Samantha Fahy", "John Attia", "Elizabeth G. Holliday", "Rodney J. Scott", "F. M. Amirul Islam", "Jerome I. Rotter", "Annie K. McAuley", "Eric Boerwinkle", "E. Shyong Tai", "Vilmundur Gudnason", "David S. Siscovick", "Johannes R. Vingerling", "Tien Y. Wong"], "doi"=>"https://dx.doi.org/10.1371/journal.pgen.1001184.t004", "stats"=>{"downloads"=>0, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_The_association_between_the_four_novel_loci_and_cardiovascular_diseases_/492337", "title"=>"The association between the four novel loci and cardiovascular diseases.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2010-10-28 00:38:57"}
  • {"files"=>["https://ndownloader.figshare.com/files/821631"], "description"=>"<p>(a) Chromosome 19q13, (b) chromosome 6q24, (c) chromosome 12q24, and (d) chromosome 5q14. The blue diamonds show stage 1 p-values (discovery phase) for the top SNP at each locus, whereas the grey diamonds show the p-values following stage 2 meta-analysis including the replication cohorts for that top SNP. P-values from stage 1 for additional SNPs at each locus are colour-coded according to their linkage disequilibrium with the top SNP as follows: r<sup>2</sup><0.2 white, 0.22<0.5 yellow, 0.522>0.8 red.</p>", "links"=>[], "tags"=>["plots"], "article_id"=>491924, "categories"=>["Medicine", "Genetics"], "users"=>["M. Kamran Ikram", "Sim Xueling", "Richard A. Jensen", "Mary Frances Cotch", "Alex W. Hewitt", "M. Arfan Ikram", "Jie Jin Wang", "Ronald Klein", "Barbara E. K. Klein", "Monique M. B. Breteler", "Ning Cheung", "Gerald Liew", "Paul Mitchell", "Andre G. Uitterlinden", "Fernando Rivadeneira", "Albert Hofman", "Paulus T. V. M. de Jong", "Cornelia M. van Duijn", "Linda Kao", "Ching-Yu Cheng", "Albert Vernon Smith", "Nicole L. Glazer", "Thomas Lumley", "Barbara McKnight", "Bruce M. Psaty", "Fridbert Jonasson", "Gudny Eiriksdottir", "Thor Aspelund", "Tamara B. Harris", "Lenore J. Launer", "Kent D. Taylor", "Xiaohui Li", "Sudha K. Iyengar", "Quansheng Xi", "Theru A. Sivakumaran", "David A. Mackey", "Stuart Macgregor", "Nicholas G. Martin", "Terri L. Young", "Josh C. Bis", "Kerri L. Wiggins", "Susan R. Heckbert", "Christopher J. Hammond", "Toby Andrew", "Samantha Fahy", "John Attia", "Elizabeth G. Holliday", "Rodney J. Scott", "F. M. Amirul Islam", "Jerome I. Rotter", "Annie K. McAuley", "Eric Boerwinkle", "E. Shyong Tai", "Vilmundur Gudnason", "David S. Siscovick", "Johannes R. Vingerling", "Tien Y. Wong"], "doi"=>"https://dx.doi.org/10.1371/journal.pgen.1001184.g002", "stats"=>{"downloads"=>8, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Regional_association_plots_for_the_four_novel_loci_/491924", "title"=>"Regional association plots for the four novel loci.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2010-10-28 00:32:04"}
  • {"files"=>["https://ndownloader.figshare.com/files/821477"], "description"=>"<p>For (a) retinal venular caliber and (b) retinal arteriolar caliber.</p>", "links"=>[], "tags"=>["shown", "genomic"], "article_id"=>491769, "categories"=>["Medicine", "Genetics"], "users"=>["M. Kamran Ikram", "Sim Xueling", "Richard A. Jensen", "Mary Frances Cotch", "Alex W. Hewitt", "M. Arfan Ikram", "Jie Jin Wang", "Ronald Klein", "Barbara E. K. Klein", "Monique M. B. Breteler", "Ning Cheung", "Gerald Liew", "Paul Mitchell", "Andre G. Uitterlinden", "Fernando Rivadeneira", "Albert Hofman", "Paulus T. V. M. de Jong", "Cornelia M. van Duijn", "Linda Kao", "Ching-Yu Cheng", "Albert Vernon Smith", "Nicole L. Glazer", "Thomas Lumley", "Barbara McKnight", "Bruce M. Psaty", "Fridbert Jonasson", "Gudny Eiriksdottir", "Thor Aspelund", "Tamara B. Harris", "Lenore J. Launer", "Kent D. Taylor", "Xiaohui Li", "Sudha K. Iyengar", "Quansheng Xi", "Theru A. Sivakumaran", "David A. Mackey", "Stuart Macgregor", "Nicholas G. Martin", "Terri L. Young", "Josh C. Bis", "Kerri L. Wiggins", "Susan R. Heckbert", "Christopher J. Hammond", "Toby Andrew", "Samantha Fahy", "John Attia", "Elizabeth G. Holliday", "Rodney J. Scott", "F. M. Amirul Islam", "Jerome I. Rotter", "Annie K. McAuley", "Eric Boerwinkle", "E. Shyong Tai", "Vilmundur Gudnason", "David S. Siscovick", "Johannes R. Vingerling", "Tien Y. Wong"], "doi"=>"https://dx.doi.org/10.1371/journal.pgen.1001184.g001", "stats"=>{"downloads"=>0, "page_views"=>2, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_P_values_minus_log_transformed_are_shown_in_a_signal_intensity_Manhattan_plot_relative_to_their_genomic_position_/491769", "title"=>"P-values (minus log-transformed) are shown in a signal intensity (Manhattan) plot relative to their genomic position.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2010-10-28 00:29:29"}

PMC Usage Stats | Further Information

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Relative Metric

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