Genome-Wide Interaction-Based Association Analysis Identified Multiple New Susceptibility Loci for Common Diseases
Events
Loading … Spinner

CiteULike | Further Information

Mendeley | Further Information

{"title"=>"Genome-wide interaction-based association analysis identified multiple new susceptibility loci for common diseases", "type"=>"journal", "authors"=>[{"first_name"=>"Yang", "last_name"=>"Liu", "scopus_author_id"=>"36066740000"}, {"first_name"=>"Haiming", "last_name"=>"Xu", "scopus_author_id"=>"55703823800"}, {"first_name"=>"Suchao", "last_name"=>"Chen", "scopus_author_id"=>"36612916000"}, {"first_name"=>"Xianfeng", "last_name"=>"Chen", "scopus_author_id"=>"47160939500"}, {"first_name"=>"Zhenguo", "last_name"=>"Zhang", "scopus_author_id"=>"55721874500"}, {"first_name"=>"Zhihong", "last_name"=>"Zhu", "scopus_author_id"=>"56517265800"}, {"first_name"=>"Xueying", "last_name"=>"Qin", "scopus_author_id"=>"55126429200"}, {"first_name"=>"Landian", "last_name"=>"Hu", "scopus_author_id"=>"7401556896"}, {"first_name"=>"Jun", "last_name"=>"Zhu", "scopus_author_id"=>"7405689749"}, {"first_name"=>"Guo Ping", "last_name"=>"Zhao", "scopus_author_id"=>"7403296532"}, {"first_name"=>"Xiangyin", "last_name"=>"Kong", "scopus_author_id"=>"15742790800"}], "year"=>2011, "source"=>"PLoS Genetics", "identifiers"=>{"pmid"=>"21437271", "doi"=>"10.1371/journal.pgen.1001338", "sgr"=>"79953753220", "isbn"=>"1553-7404 (Electronic)\\r1553-7390 (Linking)", "scopus"=>"2-s2.0-79953753220", "issn"=>"15537390", "pui"=>"361565201"}, "id"=>"30407769-4bd9-31a6-aa77-629f8c0d7bc4", "abstract"=>"Recent studies on the genetic basis of common diseases have identified many loci that confer disease susceptibility. However, much of the heritability of these diseases remains unexplained. Loci involved in gene–gene interactions are considered cryptic, because they confer susceptibility, but may not generate a detectable signal on their own. These interactions may account for the “missing heritability” of common diseases. Theoretically, these interactions can be identified with the genome-wide interaction-based association analysis. But, in reality, very few gene–gene interactions have been identified with that method, and most were based on prior biological knowledge. Here, we applied a parallel computing technique that facilitated the identification of multiple new cryptic susceptibility loci involved in common diseases. We applied stringent control for false positives, and we validated our findings with independent datasets. This study demonstrated that interactions between gene loci could be successfully identified with the genome-wide interaction-based approach. With this approach, we also identified cryptic loci with moderate single-locus effects. The identified loci and interactions merit further investigations for fine mapping and functional analyses. Our results extend the current knowledge of common diseases for future studies in genetic mapping. This approach is applicable to current and future genome-wide association datasets.", "link"=>"http://www.mendeley.com/research/genomewide-interactionbased-association-analysis-identified-multiple-new-susceptibility-loci-common", "reader_count"=>112, "reader_count_by_academic_status"=>{"Unspecified"=>2, "Professor > Associate Professor"=>9, "Researcher"=>37, "Student > Doctoral Student"=>3, "Student > Ph. D. Student"=>39, "Student > Master"=>10, "Other"=>4, "Student > Bachelor"=>3, "Professor"=>5}, "reader_count_by_user_role"=>{"Unspecified"=>2, "Professor > Associate Professor"=>9, "Researcher"=>37, "Student > Doctoral Student"=>3, "Student > Ph. D. Student"=>39, "Student > Master"=>10, "Other"=>4, "Student > Bachelor"=>3, "Professor"=>5}, "reader_count_by_subject_area"=>{"Unspecified"=>7, "Environmental Science"=>1, "Biochemistry, Genetics and Molecular Biology"=>5, "Mathematics"=>8, "Medicine and Dentistry"=>17, "Agricultural and Biological Sciences"=>55, "Neuroscience"=>1, "Physics and Astronomy"=>1, "Chemistry"=>2, "Computer Science"=>13, "Linguistics"=>1, "Energy"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>17}, "Neuroscience"=>{"Neuroscience"=>1}, "Chemistry"=>{"Chemistry"=>2}, "Energy"=>{"Energy"=>1}, "Physics and Astronomy"=>{"Physics and Astronomy"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>55}, "Computer Science"=>{"Computer Science"=>13}, "Linguistics"=>{"Linguistics"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>5}, "Mathematics"=>{"Mathematics"=>8}, "Unspecified"=>{"Unspecified"=>7}, "Environmental Science"=>{"Environmental Science"=>1}}, "reader_count_by_country"=>{"Canada"=>1, "Austria"=>1, "Netherlands"=>1, "United States"=>9, "China"=>1, "Ireland"=>1, "Philippines"=>1, "United Kingdom"=>2, "Mexico"=>1, "Australia"=>2, "France"=>1, "Germany"=>3}, "group_count"=>5}

CrossRef

Scopus | Further Information

{"@_fa"=>"true", "link"=>[{"@_fa"=>"true", "@ref"=>"self", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/79953753220"}, {"@_fa"=>"true", "@ref"=>"author-affiliation", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/79953753220?field=author,affiliation"}, {"@_fa"=>"true", "@ref"=>"scopus", "@href"=>"https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=79953753220&origin=inward"}, {"@_fa"=>"true", "@ref"=>"scopus-citedby", "@href"=>"https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=79953753220&origin=inward"}], "prism:url"=>"https://api.elsevier.com/content/abstract/scopus_id/79953753220", "dc:identifier"=>"SCOPUS_ID:79953753220", "eid"=>"2-s2.0-79953753220", "dc:title"=>"Genome-wide interaction-based association analysis identified multiple new susceptibility loci for common diseases", "dc:creator"=>"Liu Y.", "prism:publicationName"=>"PLoS Genetics", "prism:issn"=>"15537390", "prism:eIssn"=>"15537404", "prism:volume"=>"7", "prism:issueIdentifier"=>"3", "prism:pageRange"=>nil, "prism:coverDate"=>"2011-03-01", "prism:coverDisplayDate"=>"March 2011", "prism:doi"=>"10.1371/journal.pgen.1001338", "citedby-count"=>"53", "affiliation"=>[{"@_fa"=>"true", "affilname"=>"Shanghai Jiao Tong University School of Medicine", "affiliation-city"=>"Shanghai", "affiliation-country"=>"China"}], "pubmed-id"=>"21437271", "prism:aggregationType"=>"Journal", "subtype"=>"ar", "subtypeDescription"=>"Article", "article-number"=>"e1001338", "source-id"=>"4000151808", "openaccess"=>"1", "openaccessFlag"=>true}

Facebook

  • {"url"=>"http%3A%2F%2Fjournals.plos.org%2Fplosgenetics%2Farticle%3Fid%3D10.1371%252Fjournal.pgen.1001338", "share_count"=>0, "like_count"=>0, "comment_count"=>0, "click_count"=>0, "total_count"=>0}

Counter

  • {"month"=>"3", "year"=>"2011", "pdf_views"=>"381", "xml_views"=>"8", "html_views"=>"1265"}
  • {"month"=>"4", "year"=>"2011", "pdf_views"=>"206", "xml_views"=>"10", "html_views"=>"710"}
  • {"month"=>"5", "year"=>"2011", "pdf_views"=>"53", "xml_views"=>"1", "html_views"=>"202"}
  • {"month"=>"6", "year"=>"2011", "pdf_views"=>"47", "xml_views"=>"2", "html_views"=>"149"}
  • {"month"=>"7", "year"=>"2011", "pdf_views"=>"34", "xml_views"=>"1", "html_views"=>"138"}
  • {"month"=>"8", "year"=>"2011", "pdf_views"=>"30", "xml_views"=>"1", "html_views"=>"157"}
  • {"month"=>"9", "year"=>"2011", "pdf_views"=>"36", "xml_views"=>"0", "html_views"=>"131"}
  • {"month"=>"10", "year"=>"2011", "pdf_views"=>"34", "xml_views"=>"0", "html_views"=>"101"}
  • {"month"=>"11", "year"=>"2011", "pdf_views"=>"32", "xml_views"=>"5", "html_views"=>"97"}
  • {"month"=>"12", "year"=>"2011", "pdf_views"=>"26", "xml_views"=>"1", "html_views"=>"105"}
  • {"month"=>"1", "year"=>"2012", "pdf_views"=>"38", "xml_views"=>"0", "html_views"=>"123"}
  • {"month"=>"2", "year"=>"2012", "pdf_views"=>"33", "xml_views"=>"0", "html_views"=>"112"}
  • {"month"=>"3", "year"=>"2012", "pdf_views"=>"23", "xml_views"=>"1", "html_views"=>"125"}
  • {"month"=>"4", "year"=>"2012", "pdf_views"=>"29", "xml_views"=>"1", "html_views"=>"138"}
  • {"month"=>"5", "year"=>"2012", "pdf_views"=>"20", "xml_views"=>"4", "html_views"=>"312"}
  • {"month"=>"6", "year"=>"2012", "pdf_views"=>"19", "xml_views"=>"4", "html_views"=>"126"}
  • {"month"=>"7", "year"=>"2012", "pdf_views"=>"25", "xml_views"=>"0", "html_views"=>"145"}
  • {"month"=>"8", "year"=>"2012", "pdf_views"=>"26", "xml_views"=>"15", "html_views"=>"130"}
  • {"month"=>"9", "year"=>"2012", "pdf_views"=>"18", "xml_views"=>"2", "html_views"=>"147"}
  • {"month"=>"10", "year"=>"2012", "pdf_views"=>"22", "xml_views"=>"1", "html_views"=>"190"}
  • {"month"=>"11", "year"=>"2012", "pdf_views"=>"21", "xml_views"=>"0", "html_views"=>"176"}
  • {"month"=>"12", "year"=>"2012", "pdf_views"=>"28", "xml_views"=>"1", "html_views"=>"116"}
  • {"month"=>"1", "year"=>"2013", "pdf_views"=>"18", "xml_views"=>"0", "html_views"=>"141"}
  • {"month"=>"2", "year"=>"2013", "pdf_views"=>"18", "xml_views"=>"2", "html_views"=>"236"}
  • {"month"=>"3", "year"=>"2013", "pdf_views"=>"17", "xml_views"=>"1", "html_views"=>"92"}
  • {"month"=>"4", "year"=>"2013", "pdf_views"=>"18", "xml_views"=>"0", "html_views"=>"95"}
  • {"month"=>"5", "year"=>"2013", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"111"}
  • {"month"=>"6", "year"=>"2013", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"89"}
  • {"month"=>"7", "year"=>"2013", "pdf_views"=>"14", "xml_views"=>"0", "html_views"=>"92"}
  • {"month"=>"8", "year"=>"2013", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"77"}
  • {"month"=>"9", "year"=>"2013", "pdf_views"=>"16", "xml_views"=>"0", "html_views"=>"67"}
  • {"month"=>"10", "year"=>"2013", "pdf_views"=>"17", "xml_views"=>"1", "html_views"=>"93"}
  • {"month"=>"11", "year"=>"2013", "pdf_views"=>"16", "xml_views"=>"1", "html_views"=>"82"}
  • {"month"=>"12", "year"=>"2013", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"69"}
  • {"month"=>"1", "year"=>"2014", "pdf_views"=>"15", "xml_views"=>"1", "html_views"=>"75"}
  • {"month"=>"2", "year"=>"2014", "pdf_views"=>"17", "xml_views"=>"0", "html_views"=>"99"}
  • {"month"=>"3", "year"=>"2014", "pdf_views"=>"20", "xml_views"=>"2", "html_views"=>"91"}
  • {"month"=>"4", "year"=>"2014", "pdf_views"=>"11", "xml_views"=>"1", "html_views"=>"67"}
  • {"month"=>"5", "year"=>"2014", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"40"}
  • {"month"=>"6", "year"=>"2014", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"42"}
  • {"month"=>"7", "year"=>"2014", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"59"}
  • {"month"=>"8", "year"=>"2014", "pdf_views"=>"11", "xml_views"=>"2", "html_views"=>"49"}
  • {"month"=>"9", "year"=>"2014", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"62"}
  • {"month"=>"10", "year"=>"2014", "pdf_views"=>"7", "xml_views"=>"2", "html_views"=>"85"}
  • {"month"=>"11", "year"=>"2014", "pdf_views"=>"6", "xml_views"=>"1", "html_views"=>"72"}
  • {"month"=>"12", "year"=>"2014", "pdf_views"=>"7", "xml_views"=>"2", "html_views"=>"45"}
  • {"month"=>"1", "year"=>"2015", "pdf_views"=>"11", "xml_views"=>"1", "html_views"=>"112"}
  • {"month"=>"2", "year"=>"2015", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"30"}
  • {"month"=>"3", "year"=>"2015", "pdf_views"=>"14", "xml_views"=>"0", "html_views"=>"48"}
  • {"month"=>"4", "year"=>"2015", "pdf_views"=>"7", "xml_views"=>"1", "html_views"=>"38"}
  • {"month"=>"5", "year"=>"2015", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"46"}
  • {"month"=>"6", "year"=>"2015", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"52"}
  • {"month"=>"7", "year"=>"2015", "pdf_views"=>"16", "xml_views"=>"0", "html_views"=>"64"}
  • {"month"=>"8", "year"=>"2015", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"51"}
  • {"month"=>"9", "year"=>"2015", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"41"}
  • {"month"=>"10", "year"=>"2015", "pdf_views"=>"23", "xml_views"=>"0", "html_views"=>"34"}
  • {"month"=>"11", "year"=>"2015", "pdf_views"=>"10", "xml_views"=>"1", "html_views"=>"43"}
  • {"month"=>"12", "year"=>"2015", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"24"}
  • {"month"=>"1", "year"=>"2016", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"36"}
  • {"month"=>"2", "year"=>"2016", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"19"}
  • {"month"=>"3", "year"=>"2016", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"27"}
  • {"month"=>"4", "year"=>"2016", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"23"}
  • {"month"=>"5", "year"=>"2016", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"29"}
  • {"month"=>"6", "year"=>"2016", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"13"}
  • {"month"=>"7", "year"=>"2016", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"32"}
  • {"month"=>"8", "year"=>"2016", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"21"}
  • {"month"=>"9", "year"=>"2016", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"57"}
  • {"month"=>"10", "year"=>"2016", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"25"}
  • {"month"=>"11", "year"=>"2016", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"25"}
  • {"month"=>"12", "year"=>"2016", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"20"}
  • {"month"=>"1", "year"=>"2017", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"20"}
  • {"month"=>"2", "year"=>"2017", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"32"}
  • {"month"=>"3", "year"=>"2017", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"43"}
  • {"month"=>"4", "year"=>"2017", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"28"}
  • {"month"=>"5", "year"=>"2017", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"31"}
  • {"month"=>"6", "year"=>"2017", "pdf_views"=>"0", "xml_views"=>"0", "html_views"=>"17"}
  • {"month"=>"7", "year"=>"2017", "pdf_views"=>"11", "xml_views"=>"1", "html_views"=>"37"}
  • {"month"=>"8", "year"=>"2017", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"22"}
  • {"month"=>"9", "year"=>"2017", "pdf_views"=>"7", "xml_views"=>"1", "html_views"=>"19"}
  • {"month"=>"10", "year"=>"2017", "pdf_views"=>"6", "xml_views"=>"2", "html_views"=>"24"}
  • {"month"=>"11", "year"=>"2017", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"32"}
  • {"month"=>"12", "year"=>"2017", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"22"}
  • {"month"=>"1", "year"=>"2018", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"31"}
  • {"month"=>"2", "year"=>"2018", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"25"}
  • {"month"=>"3", "year"=>"2018", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"26"}
  • {"month"=>"4", "year"=>"2018", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"17"}
  • {"month"=>"5", "year"=>"2018", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"11"}
  • {"month"=>"6", "year"=>"2018", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"25"}
  • {"month"=>"7", "year"=>"2018", "pdf_views"=>"5", "xml_views"=>"4", "html_views"=>"20"}
  • {"month"=>"8", "year"=>"2018", "pdf_views"=>"1", "xml_views"=>"1", "html_views"=>"10"}
  • {"month"=>"9", "year"=>"2018", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"7"}
  • {"month"=>"10", "year"=>"2018", "pdf_views"=>"11", "xml_views"=>"2", "html_views"=>"11"}
  • {"month"=>"11", "year"=>"2018", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"7"}
  • {"month"=>"12", "year"=>"2018", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"10"}
  • {"month"=>"1", "year"=>"2019", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"7"}
  • {"month"=>"2", "year"=>"2019", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"9"}
  • {"month"=>"3", "year"=>"2019", "pdf_views"=>"7", "xml_views"=>"1", "html_views"=>"9"}
  • {"month"=>"4", "year"=>"2019", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"4"}
  • {"month"=>"5", "year"=>"2019", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"8"}
  • {"month"=>"6", "year"=>"2019", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"8"}
  • {"month"=>"7", "year"=>"2019", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"8"}
  • {"month"=>"8", "year"=>"2019", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"5"}
  • {"month"=>"9", "year"=>"2019", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"9"}
  • {"month"=>"10", "year"=>"2019", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"5"}

Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/395620", "https://ndownloader.figshare.com/files/395652", "https://ndownloader.figshare.com/files/395682", "https://ndownloader.figshare.com/files/395733", "https://ndownloader.figshare.com/files/395756", "https://ndownloader.figshare.com/files/395779", "https://ndownloader.figshare.com/files/395799", "https://ndownloader.figshare.com/files/395827", "https://ndownloader.figshare.com/files/395864", "https://ndownloader.figshare.com/files/395911"], "description"=>"<div><p>Genome-wide interaction-based association (GWIBA) analysis has the potential to identify novel susceptibility loci. These interaction effects could be missed with the prevailing approaches in genome-wide association studies (GWAS). However, no convincing loci have been discovered exclusively from GWIBA methods, and the intensive computation involved is a major barrier for application. Here, we developed a fast, multi-thread/parallel program named “pair-wise interaction-based association mapping” (PIAM) for exhaustive two-locus searches. With this program, we performed a complete GWIBA analysis on seven diseases with stringent control for false positives, and we validated the results for three of these diseases. We identified one pair-wise interaction between a previously identified locus, <em>C1orf106</em>, and one new locus, <em>TEC</em>, that was specific for Crohn's disease, with a Bonferroni corrected <em>P</em><0.05 (<em>P</em> = 0.039). This interaction was replicated with a pair of proxy linked loci (<em>P</em> = 0.013) on an independent dataset. Five other interactions had corrected <em>P</em><0.5. We identified the allelic effect of a locus close to <em>SLC7A13</em> for coronary artery disease. This was replicated with a linked locus on an independent dataset (<em>P</em> = 1.09×10<sup>−7</sup>). Through a local validation analysis that evaluated association signals, rather than locus-based associations, we found that several other regions showed association/interaction signals with nominal <em>P</em><0.05. In conclusion, this study demonstrated that the GWIBA approach was successful for identifying novel loci, and the results provide new insights into the genetic architecture of common diseases. In addition, our PIAM program was capable of handling very large GWAS datasets that are likely to be produced in the future.</p></div>", "links"=>[], "tags"=>["genome-wide", "interaction-based", "identified", "susceptibility", "loci", "diseases"], "article_id"=>138156, "categories"=>["Genetics"], "users"=>["Yang Liu", "Haiming Xu", "Suchao Chen", "Xianfeng Chen", "Zhenguo Zhang", "Zhihong Zhu", "Xueying Qin", "Landian Hu", "Jun Zhu", "Guo-Ping Zhao", "Xiangyin Kong"], "doi"=>["https://dx.doi.org/10.1371/journal.pgen.1001338.s001", "https://dx.doi.org/10.1371/journal.pgen.1001338.s002", "https://dx.doi.org/10.1371/journal.pgen.1001338.s003", "https://dx.doi.org/10.1371/journal.pgen.1001338.s004", "https://dx.doi.org/10.1371/journal.pgen.1001338.s005", "https://dx.doi.org/10.1371/journal.pgen.1001338.s006", "https://dx.doi.org/10.1371/journal.pgen.1001338.s007", "https://dx.doi.org/10.1371/journal.pgen.1001338.s008", "https://dx.doi.org/10.1371/journal.pgen.1001338.s009", "https://dx.doi.org/10.1371/journal.pgen.1001338.s010"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Genome_Wide_Interaction_Based_Association_Analysis_Identified_Multiple_New_Susceptibility_Loci_for_Common_Diseases/138156", "title"=>"Genome-Wide Interaction-Based Association Analysis Identified Multiple New Susceptibility Loci for Common Diseases", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2011-03-17 02:15:56"}
  • {"files"=>["https://ndownloader.figshare.com/files/790163"], "description"=>"<p>SNPs within 100 kb of the most significant SNP pairs are shown. For each panel, the upper left plot is the color key for the interaction signal plot at the lower right; the lower left and upper right plots are single-locus signal plots with gene annotations. These plots are aligned by chromosome positions in Mb, which are based on NCBI build 36. The red dotted lines and the red dot in the middle indicate the position of the most significant pair of SNPs in the corresponding regions. The solid black dots in the single-locus signal plots denote the trend test <i>p</i>-values (values indicated by the numbered axes) and the colored images in the interaction signal plots denote the pure interaction <i>p</i>-values (values indicated by the color key in the upper left box); these were obtained with the shared controls and transformed by a negative logarithm.</p>", "links"=>[], "tags"=>["plots", "interactions", "wtccc"], "article_id"=>460518, "categories"=>["Genetics"], "users"=>["Yang Liu", "Haiming Xu", "Suchao Chen", "Xianfeng Chen", "Zhenguo Zhang", "Zhihong Zhu", "Xueying Qin", "Landian Hu", "Jun Zhu", "Guo-Ping Zhao", "Xiangyin Kong"], "doi"=>["https://dx.doi.org/10.1371/journal.pgen.1001338.g001"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Regional_signal_plots_of_the_interactions_in_Table_1_with_WTCCC_data_/460518", "title"=>"Regional signal plots of the interactions in <b>Table 1</b> with WTCCC data.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-03-17 00:08:38"}
  • {"files"=>["https://ndownloader.figshare.com/files/790279"], "description"=>"<p>The signal plots of three interactions for CD and two interactions for T2D are shown. The interactions were observed in the IBDGC non-Jewish population data and the GENEVA Diabetes Study data, respectively. The format of this figure is similar to that described in <a href=\"http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1001338#pgen-1001338-g001\" target=\"_blank\">Figure 1</a>; the red dotted lines and the red dot in the middle indicate the positions of the originally identified SNP pair. Two other red dotted lines for each single-locus signal plot and the red box in the interaction signal plot were added to indicate the regions used for the local validation tests; the blue dotted lines indicate the <i>p</i>-value thresholds of 0.05. (The interaction between rs7522462 and rs11945978 was replicated by proxy SNPs; therefore, its local validation was disregarded).</p>", "links"=>[], "tags"=>["plots", "interactions", "observed", "validation"], "article_id"=>460636, "categories"=>["Genetics"], "users"=>["Yang Liu", "Haiming Xu", "Suchao Chen", "Xianfeng Chen", "Zhenguo Zhang", "Zhihong Zhu", "Xueying Qin", "Landian Hu", "Jun Zhu", "Guo-Ping Zhao", "Xiangyin Kong"], "doi"=>["https://dx.doi.org/10.1371/journal.pgen.1001338.g002"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Regional_signal_plots_of_the_interactions_observed_in_validation_datasets_/460636", "title"=>"Regional signal plots of the interactions observed in validation datasets.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-03-17 00:10:36"}
  • {"files"=>["https://ndownloader.figshare.com/files/790389"], "description"=>"<p>(A) For each two-locus genotype combination, a genotype code is shown in the upper left corner of each cell. NN denotes missing genotypes. The distribution of RA cases (left bar) and controls (right bar) in each genotype combination is shown with the number of observations indicated above the bars. The samples are mainly distributed on the diagonal of the genotype combinations, where two SNPs are in LD. Note that many genotype combinations are sparse. An excessive number of cases relative to controls was observed for the genotype combination TC for rs1343295 and TT for rs7543540 (code 4), which primarily caused the association. (B) Genotype combination codes (1–10) of samples were plotted against the plate and well numbers of samples in 96-well plates. Codes 1–9 denote the nine non-missing genotypes shown in (A). Samples with missing genotypes were grouped in code 10. The vertical line separates cases (left) and controls (right). The 59 cases of one particular genotype combination (code 4) were not evenly distributed among the wells, but severely aggregated. (C) Cluster plot for RA cases. The coordinates denote the allele intensities of the first SNP in the title (rs1343295) and the 10 colors denote the 10 genotype combinations of the two SNPs. The genotype clustering of 59 cases (plotted in cyan circles) are ambiguous between heterozygotes and homozygotes for rs1343295, and genotypes were considered heterozygotes. In fact, the genotypes of these 59 cases should probably be considered homozygotes, and then no association would exist; however, the batch effect produced this artificial error due to the low-quality genotyping and subsequent artificial clustering.</p>", "links"=>[], "tags"=>["observed", "snps", "rs1343295"], "article_id"=>460749, "categories"=>["Genetics"], "users"=>["Yang Liu", "Haiming Xu", "Suchao Chen", "Xianfeng Chen", "Zhenguo Zhang", "Zhihong Zhu", "Xueying Qin", "Landian Hu", "Jun Zhu", "Guo-Ping Zhao", "Xiangyin Kong"], "doi"=>["https://dx.doi.org/10.1371/journal.pgen.1001338.g003"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Batch_effect_observed_for_SNPs_rs1343295_and_rs7543540_/460749", "title"=>"Batch effect observed for SNPs rs1343295 and rs7543540.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-03-17 00:12:29"}
  • {"files"=>["https://ndownloader.figshare.com/files/790484"], "description"=>"<p>The legend to this figure is the same as that for <a href=\"http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1001338#pgen-1001338-g003\" target=\"_blank\">Figure 3</a>, except that the associated disease is HT, and the population was divided into two cohorts (C and D). The description of (D) is the same as that for (C), except that the 1958 birth cohort control samples were plotted in (D). (A) The situation here is similar to that shown in <a href=\"http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1001338#pgen-1001338-g003\" target=\"_blank\">Figure 3A</a>, with an excessive number of cases compared to control; in the genotype combination of AG for rs6578234 and CC for rs7827545 (code 4), 109 cases and only 1 control were observed. However, the batch effect did not occur, because all the plates showed association signals for this combination (B, genotype combination 4). Instead, a fourth cluster is observed in both case and control groups (C and D); the pattern in the two groups is the same, but the genotypes were assigned different codes for cases and controls by the genotype calling algorithm CHIAMO. The genotypes of rs7827545 of the 109 HT cases were called homozygotes (C, indicated in cyan, code 4), and the genotypes in the controls were called heterozygotes (D, indicated in pink, code 5). In fact, the genotypes of rs7827545 of the 109 cases should probably be considered heterozygotes, as in the controls, and no association should exist. We do not know the cause of the fourth genotype cluster, because the clustering pattern could not be explained by multiple clusters of copy number variation.</p>", "links"=>[], "tags"=>["clustering", "observed", "rs6578234"], "article_id"=>460840, "categories"=>["Genetics"], "users"=>["Yang Liu", "Haiming Xu", "Suchao Chen", "Xianfeng Chen", "Zhenguo Zhang", "Zhihong Zhu", "Xueying Qin", "Landian Hu", "Jun Zhu", "Guo-Ping Zhao", "Xiangyin Kong"], "doi"=>["https://dx.doi.org/10.1371/journal.pgen.1001338.g004"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Genotype_clustering_problem_observed_for_rs6578234_and_rs7827545_/460840", "title"=>"Genotype clustering problem observed for rs6578234 and rs7827545.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-03-17 00:14:00"}
  • {"files"=>["https://ndownloader.figshare.com/files/790772"], "description"=>"<p>OR (95%CI): Odds ratios with 95% confidence intervals.</p>", "links"=>[], "tags"=>["rs13262822", "associations", "wtccc", "cad", "germifs"], "article_id"=>461124, "categories"=>["Genetics"], "users"=>["Yang Liu", "Haiming Xu", "Suchao Chen", "Xianfeng Chen", "Zhenguo Zhang", "Zhihong Zhu", "Xueying Qin", "Landian Hu", "Jun Zhu", "Guo-Ping Zhao", "Xiangyin Kong"], "doi"=>["https://dx.doi.org/10.1371/journal.pgen.1001338.t004"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Comparison_of_rs13262822_associations_in_the_WTCCC_CAD_data_and_the_GerMIFS_data_/461124", "title"=>"Comparison of rs13262822 associations in the WTCCC CAD data and the GerMIFS data.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2011-03-17 00:18:44"}
  • {"files"=>["https://ndownloader.figshare.com/files/790813"], "description"=>"<p>Comparison of OR tables between the interaction of rs7522462 and rs11945978 in the WTCCC data with the shared controls (left) and the interaction of the proxy SNPs, rs296533 and rs2089509 in the IBDGC data (right). The legend to this table is the same as that of <a href=\"http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1001338#pgen-1001338-t003\" target=\"_blank\">Table 3</a>.</p>", "links"=>[], "tags"=>["tables", "datasets", "cd"], "article_id"=>461175, "categories"=>["Genetics"], "users"=>["Yang Liu", "Haiming Xu", "Suchao Chen", "Xianfeng Chen", "Zhenguo Zhang", "Zhihong Zhu", "Xueying Qin", "Landian Hu", "Jun Zhu", "Guo-Ping Zhao", "Xiangyin Kong"], "doi"=>["https://dx.doi.org/10.1371/journal.pgen.1001338.t005"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Comparison_of_OR_tables_between_two_datasets_for_one_CD_interaction_/461175", "title"=>"Comparison of OR tables between two datasets for one CD interaction.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2011-03-17 00:19:35"}
  • {"files"=>["https://ndownloader.figshare.com/files/790859"], "description"=>"<p>Each row represents one gene-gene interaction listed in <a href=\"http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1001338#pgen-1001338-t001\" target=\"_blank\">Table 1</a>. Chi-square tests of 3 by 3 contingency tables were used to determine whether two SNPs were dependent in the case group or in the control group. For each test, 10,000 Monte Carlo simulations were used to obtain the <i>p</i>-value; each test was repeated 3 times for both the case group and the control group. The tests were performed with the R statistical software (<a href=\"http://www.r-project.org/\" target=\"_blank\">http://www.r-project.org/</a>).</p>", "links"=>[], "tags"=>["snp", "interactions", "observed"], "article_id"=>461217, "categories"=>["Genetics"], "users"=>["Yang Liu", "Haiming Xu", "Suchao Chen", "Xianfeng Chen", "Zhenguo Zhang", "Zhihong Zhu", "Xueying Qin", "Landian Hu", "Jun Zhu", "Guo-Ping Zhao", "Xiangyin Kong"], "doi"=>["https://dx.doi.org/10.1371/journal.pgen.1001338.t002"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Tests_for_SNP_independence_in_the_interactions_observed_in_the_case_and_control_groups_/461217", "title"=>"Tests for SNP independence in the interactions observed in the case and control groups.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2011-03-17 00:20:17"}
  • {"files"=>["https://ndownloader.figshare.com/files/790904"], "description"=>"<p>This table facilitates the interpretation of the statistical interactions. The statistics were obtained with the shared controls. For each SNP pair, there are three odds ratio tables: the OR, OR1, and OR2. Each OR table has 9 odds ratio values for 9 genotype combinations. 95% confidence intervals are shown in parentheses. OR: odds ratios of the two-locus genotype combinations, relative to the most common homozygote combination. OR1 and OR2: odds ratios of one of the two SNPs, where the samples were stratified by the genotypes of the other SNP; the interaction is indicated by different odds ratio values of one SNP between different genotype strata of the other SNP.</p>", "links"=>[], "tags"=>["tables", "snp", "pairs", "shown"], "article_id"=>461262, "categories"=>["Genetics"], "users"=>["Yang Liu", "Haiming Xu", "Suchao Chen", "Xianfeng Chen", "Zhenguo Zhang", "Zhihong Zhu", "Xueying Qin", "Landian Hu", "Jun Zhu", "Guo-Ping Zhao", "Xiangyin Kong"], "doi"=>["https://dx.doi.org/10.1371/journal.pgen.1001338.t003"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_OR_tables_for_the_SNP_pairs_shown_in_Table_1_/461262", "title"=>"OR tables for the SNP pairs shown in Table 1.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2011-03-17 00:21:02"}
  • {"files"=>["https://ndownloader.figshare.com/files/790946"], "description"=>"<p>Six pairs of SNPs that represented interacting loci. Chr: chromosome and cytoband information. Nearest Gene: When the nearest annotated gene was >500 kb away from the SNPs, it was not listed. The trend <i>p</i>-values were obtained with the shared controls. The validation of allelic effect for loci with original trend <i>p</i>-values>0.05 is not presented. Validation status: Unavailable, data unavailable for validation; <i>P</i><sub>PR</sub>, <i>p</i>-value of the proxy replication; Meta-analysis, susceptibility locus found by meta-analysis studies after the WTCCC study; Not significant, validation was not significant (<i>P</i>>0.05); Known region, a susceptibility region that was known at the time of the WTCCC study; <i>P</i><sub>LV</sub>, <i>p</i>-value of the local validation. The last five columns contain the interaction results. Pure interaction <i>p</i>-values were obtained with the shared controls. Two-locus <i>p</i>-value (expanded): two-locus LRT <i>p</i>-value according to the search situation, and the two-locus <i>p</i>-values and the corresponding corrected <i>p</i>-values for the final significance were obtained in the expanded control analysis.</p><p>*Bonferroni corrected <i>P</i><0.05. Because all of these loci were obtained in the simultaneous searches, in which the two-locus tests took account of all effects of the two loci, therefore the main effects and the interaction effects were examined in the validation analyses, and the following criterion was used to determine the validation status of each locus: (1) if the pure interaction effect was validated (i.e. <i>P</i><0.05), both of the loci and their interaction effect were validated, irrespective of the validations of the main effects; (2) if the pure interaction effect was not validated, then the validation status of a locus was determined by the validation of its main effect.</p>", "links"=>[], "tags"=>["genetics and genomics/bioinformatics", "genetics and genomics/genetics of disease", "genetics and genomics/medical genetics"], "article_id"=>461303, "categories"=>["Genetics"], "users"=>["Yang Liu", "Haiming Xu", "Suchao Chen", "Xianfeng Chen", "Zhenguo Zhang", "Zhihong Zhu", "Xueying Qin", "Landian Hu", "Jun Zhu", "Guo-Ping Zhao", "Xiangyin Kong"], "doi"=>["https://dx.doi.org/10.1371/journal.pgen.1001338.t001"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Identified_gene_interactions_/461303", "title"=>"Identified gene interactions.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2011-03-17 00:21:43"}

PMC Usage Stats | Further Information

  • {"month"=>"3", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"2", "full-text"=>"16", "year"=>"2011", "pdf"=>"7", "unique-ip"=>"18", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"4", "cited-by"=>"0", "abstract"=>"4", "full-text"=>"47", "unique-ip"=>"59", "pdf"=>"42", "year"=>"2011", "figure"=>"13", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"5", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"2", "full-text"=>"52", "year"=>"2011", "pdf"=>"40", "unique-ip"=>"49", "figure"=>"5", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"6", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"25", "unique-ip"=>"26", "pdf"=>"13", "year"=>"2011", "figure"=>"5", "scanned-summary"=>"0", "supp-data"=>"2"}
  • {"month"=>"7", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"35", "year"=>"2011", "pdf"=>"17", "unique-ip"=>"28", "figure"=>"1", "scanned-summary"=>"0", "supp-data"=>"5"}
  • {"scanned-page-browse"=>"0", "month"=>"8", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"43", "unique-ip"=>"37", "pdf"=>"33", "year"=>"2011", "figure"=>"2", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"9", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"34", "year"=>"2011", "pdf"=>"14", "unique-ip"=>"28", "figure"=>"2", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"10", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"29", "unique-ip"=>"26", "pdf"=>"11", "year"=>"2011", "figure"=>"4", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"11", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"40", "year"=>"2011", "pdf"=>"35", "unique-ip"=>"39", "figure"=>"2", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"12", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"34", "unique-ip"=>"33", "pdf"=>"22", "year"=>"2011", "figure"=>"10", "scanned-summary"=>"0", "supp-data"=>"9"}
  • {"scanned-page-browse"=>"0", "month"=>"1", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"18", "unique-ip"=>"15", "pdf"=>"8", "year"=>"2012", "figure"=>"3", "scanned-summary"=>"0", "supp-data"=>"8"}
  • {"month"=>"2", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"26", "year"=>"2012", "pdf"=>"10", "unique-ip"=>"26", "figure"=>"1", "scanned-summary"=>"0", "supp-data"=>"2"}
  • {"scanned-page-browse"=>"0", "month"=>"3", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"23", "unique-ip"=>"20", "pdf"=>"12", "year"=>"2012", "figure"=>"2", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"4", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"18", "year"=>"2012", "pdf"=>"10", "unique-ip"=>"16", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"3"}
  • {"scanned-page-browse"=>"0", "month"=>"5", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"18", "unique-ip"=>"17", "pdf"=>"7", "year"=>"2012", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"6", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"16", "year"=>"2012", "pdf"=>"12", "unique-ip"=>"17", "figure"=>"3", "scanned-summary"=>"0", "supp-data"=>"1"}
  • {"unique-ip"=>"18", "full-text"=>"16", "pdf"=>"2", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"7"}
  • {"unique-ip"=>"14", "full-text"=>"14", "pdf"=>"3", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"8"}
  • {"unique-ip"=>"11", "full-text"=>"11", "pdf"=>"10", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"9"}
  • {"unique-ip"=>"15", "full-text"=>"19", "pdf"=>"3", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2012", "month"=>"10"}
  • {"unique-ip"=>"12", "full-text"=>"14", "pdf"=>"7", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2012", "month"=>"12"}
  • {"unique-ip"=>"20", "full-text"=>"28", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2013", "month"=>"1"}
  • {"unique-ip"=>"16", "full-text"=>"16", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2013", "month"=>"2"}
  • {"unique-ip"=>"16", "full-text"=>"30", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"3"}
  • {"unique-ip"=>"6", "full-text"=>"6", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"4"}
  • {"unique-ip"=>"19", "full-text"=>"17", "pdf"=>"10", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"11"}
  • {"unique-ip"=>"12", "full-text"=>"13", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"5"}
  • {"unique-ip"=>"5", "full-text"=>"3", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"6"}
  • {"unique-ip"=>"13", "full-text"=>"12", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"10", "cited-by"=>"0", "year"=>"2013", "month"=>"7"}
  • {"unique-ip"=>"4", "full-text"=>"3", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"8"}
  • {"unique-ip"=>"4", "full-text"=>"3", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"10", "cited-by"=>"0", "year"=>"2013", "month"=>"9"}
  • {"unique-ip"=>"12", "full-text"=>"19", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"10"}
  • {"unique-ip"=>"9", "full-text"=>"12", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"11"}
  • {"unique-ip"=>"10", "full-text"=>"10", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"12"}
  • {"unique-ip"=>"11", "full-text"=>"9", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2014", "month"=>"1"}
  • {"unique-ip"=>"4", "full-text"=>"8", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"2"}
  • {"unique-ip"=>"8", "full-text"=>"7", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"3"}
  • {"unique-ip"=>"7", "full-text"=>"6", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"5"}
  • {"unique-ip"=>"13", "full-text"=>"11", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"6"}
  • {"unique-ip"=>"17", "full-text"=>"12", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2014", "month"=>"4"}
  • {"unique-ip"=>"16", "full-text"=>"15", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2014", "month"=>"7"}
  • {"unique-ip"=>"13", "full-text"=>"8", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"8"}
  • {"unique-ip"=>"17", "full-text"=>"12", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2014", "month"=>"9"}
  • {"unique-ip"=>"20", "full-text"=>"21", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"10"}
  • {"unique-ip"=>"11", "full-text"=>"8", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2014", "month"=>"11"}
  • {"unique-ip"=>"10", "full-text"=>"8", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"12"}
  • {"unique-ip"=>"12", "full-text"=>"12", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2015", "month"=>"1"}
  • {"unique-ip"=>"13", "full-text"=>"12", "pdf"=>"10", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2015", "month"=>"2"}
  • {"unique-ip"=>"14", "full-text"=>"9", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2015", "month"=>"3"}
  • {"unique-ip"=>"26", "full-text"=>"18", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"10", "cited-by"=>"1", "year"=>"2015", "month"=>"4"}
  • {"unique-ip"=>"7", "full-text"=>"6", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"5"}
  • {"unique-ip"=>"6", "full-text"=>"7", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"6"}
  • {"unique-ip"=>"15", "full-text"=>"15", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"7"}
  • {"unique-ip"=>"13", "full-text"=>"11", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"8"}
  • {"unique-ip"=>"27", "full-text"=>"22", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"19", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2015", "month"=>"9"}
  • {"unique-ip"=>"7", "full-text"=>"10", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"10"}
  • {"unique-ip"=>"15", "full-text"=>"15", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"3", "year"=>"2015", "month"=>"11"}
  • {"unique-ip"=>"18", "full-text"=>"13", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"8", "cited-by"=>"0", "year"=>"2015", "month"=>"12"}
  • {"unique-ip"=>"9", "full-text"=>"7", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"1"}
  • {"unique-ip"=>"10", "full-text"=>"8", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"2"}
  • {"unique-ip"=>"8", "full-text"=>"9", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"3"}
  • {"unique-ip"=>"3", "full-text"=>"4", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"4"}
  • {"unique-ip"=>"6", "full-text"=>"4", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"5"}
  • {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"6"}
  • {"unique-ip"=>"8", "full-text"=>"7", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"7"}
  • {"unique-ip"=>"6", "full-text"=>"6", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"8"}
  • {"unique-ip"=>"28", "full-text"=>"33", "pdf"=>"14", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"15", "cited-by"=>"0", "year"=>"2016", "month"=>"9"}
  • {"unique-ip"=>"15", "full-text"=>"16", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"10"}
  • {"unique-ip"=>"13", "full-text"=>"18", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"11"}
  • {"unique-ip"=>"17", "full-text"=>"34", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"8", "cited-by"=>"4", "year"=>"2016", "month"=>"12"}
  • {"unique-ip"=>"16", "full-text"=>"24", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"1"}
  • {"unique-ip"=>"15", "full-text"=>"16", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"2"}
  • {"unique-ip"=>"18", "full-text"=>"27", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"3"}
  • {"unique-ip"=>"18", "full-text"=>"26", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"4"}
  • {"unique-ip"=>"17", "full-text"=>"25", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"5"}
  • {"unique-ip"=>"14", "full-text"=>"18", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2017", "month"=>"6"}
  • {"unique-ip"=>"14", "full-text"=>"18", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"7"}
  • {"unique-ip"=>"21", "full-text"=>"30", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"8"}
  • {"unique-ip"=>"10", "full-text"=>"10", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"9"}
  • {"unique-ip"=>"10", "full-text"=>"9", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2017", "month"=>"10"}
  • {"unique-ip"=>"7", "full-text"=>"8", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"11"}
  • {"unique-ip"=>"11", "full-text"=>"7", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"12"}
  • {"unique-ip"=>"7", "full-text"=>"9", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"1"}
  • {"unique-ip"=>"12", "full-text"=>"16", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"3"}
  • {"unique-ip"=>"7", "full-text"=>"8", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"1"}
  • {"unique-ip"=>"9", "full-text"=>"12", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"5"}
  • {"unique-ip"=>"9", "full-text"=>"9", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"4"}
  • {"unique-ip"=>"10", "full-text"=>"13", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"6"}
  • {"unique-ip"=>"7", "full-text"=>"4", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2018", "month"=>"7"}
  • {"unique-ip"=>"9", "full-text"=>"6", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"7", "cited-by"=>"0", "year"=>"2018", "month"=>"8"}
  • {"unique-ip"=>"3", "full-text"=>"2", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"9"}
  • {"unique-ip"=>"8", "full-text"=>"8", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"10"}
  • {"unique-ip"=>"9", "full-text"=>"8", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2018", "month"=>"11"}
  • {"unique-ip"=>"4", "full-text"=>"5", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"12"}
  • {"unique-ip"=>"6", "full-text"=>"8", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"2"}
  • {"unique-ip"=>"2", "full-text"=>"3", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"3"}
  • {"unique-ip"=>"4", "full-text"=>"3", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"4"}
  • {"unique-ip"=>"9", "full-text"=>"8", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2019", "month"=>"5"}
  • {"unique-ip"=>"10", "full-text"=>"8", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"8"}
  • {"unique-ip"=>"9", "full-text"=>"7", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"9"}

Relative Metric

{"start_date"=>"2011-01-01T00:00:00Z", "end_date"=>"2011-12-31T00:00:00Z", "subject_areas"=>[{"subject_area"=>"/Biology and life sciences", "average_usage"=>[304, 568, 702, 818, 927, 1027, 1118, 1206, 1285, 1357, 1427, 1500, 1564, 1636, 1705, 1773, 1840, 1909, 1974, 2039, 2106, 2170, 2234, 2296, 2358, 2423, 2484, 2546, 2606, 2673, 2734, 2795, 2857, 2921, 2984, 3046, 3100]}, {"subject_area"=>"/Biology and life sciences/Computational biology", "average_usage"=>[348, 636, 778, 900, 1011, 1120, 1220, 1303, 1392, 1471, 1554, 1628, 1704, 1776, 1855, 1934, 2016, 2084, 2149, 2232, 2303, 2379, 2465, 2539, 2593, 2657, 2722, 2786, 2856, 2918, 2989, 3057, 3124, 3185, 3234, 3300, 3343]}, {"subject_area"=>"/Biology and life sciences/Molecular biology", "average_usage"=>[295, 553, 688, 802, 914, 1017, 1108, 1194, 1278, 1351, 1419, 1500, 1570, 1633, 1712, 1774, 1839, 1903, 1970, 2033, 2101, 2162, 2228, 2291, 2352, 2418, 2486, 2547, 2610, 2680, 2737, 2799, 2859, 2919, 2974, 3029, 3082]}, {"subject_area"=>"/Engineering and technology/Industrial engineering", "average_usage"=>[310, 536, 668, 780, 896, 944, 1037, 1103, 1176, 1250, 1302, 1367, 1462, 1566, 1626, 1692, 1749, 1820, 1918, 1975, 2029, 2070, 2140, 2223, 2305, 2391, 2451, 2538, 2623, 2674, 2751, 2835, 2875, 2909, 2930, 2980, 3069]}, {"subject_area"=>"/Physical sciences", "average_usage"=>[303, 547, 667, 770, 875, 974, 1062, 1140, 1210, 1276, 1344, 1408, 1473, 1534, 1602, 1665, 1732, 1800, 1863, 1920, 1984, 2048, 2099, 2161, 2222, 2285, 2341, 2404, 2473, 2528, 2595, 2650, 2713, 2772, 2835, 2886, 2938]}]}
Loading … Spinner
There are currently no alerts