B Chromosomes Have a Functional Effect on Female Sex Determination in Lake Victoria Cichlid Fishes
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{"title"=>"B chromosomes have a functional effect on female sex determination in lake victoria cichlid fishes", "type"=>"journal", "authors"=>[{"first_name"=>"Kohta", "last_name"=>"Yoshida", "scopus_author_id"=>"55634256800"}, {"first_name"=>"Yohey", "last_name"=>"Terai", "scopus_author_id"=>"7007013871"}, {"first_name"=>"Shinji", "last_name"=>"Mizoiri", "scopus_author_id"=>"6506446676"}, {"first_name"=>"Mitsuto", "last_name"=>"Aibara", "scopus_author_id"=>"15836380300"}, {"first_name"=>"Hidenori", "last_name"=>"Nishihara", "scopus_author_id"=>"7202718772"}, {"first_name"=>"Masakatsu", "last_name"=>"Watanabe", "scopus_author_id"=>"55686678400"}, {"first_name"=>"Asato", "last_name"=>"Kuroiwa", "scopus_author_id"=>"7102710293"}, {"first_name"=>"Hirohisa", "last_name"=>"Hirai", "scopus_author_id"=>"7403094599"}, {"first_name"=>"Yuriko", "last_name"=>"Hirai", "scopus_author_id"=>"7202984166"}, {"first_name"=>"Yoichi", "last_name"=>"Matsuda", "scopus_author_id"=>"35420421900"}, {"first_name"=>"Norihiro", "last_name"=>"Okada", "scopus_author_id"=>"7201737336"}], "year"=>2011, "source"=>"PLoS Genetics", "identifiers"=>{"scopus"=>"2-s2.0-80052327146", "sgr"=>"80052327146", "issn"=>"15537390", "doi"=>"10.1371/journal.pgen.1002203", "pmid"=>"21876673", "isbn"=>"1553-7390", "pui"=>"362471751"}, "id"=>"1632f7ab-7b19-3246-8474-aaa0ddd0e10d", "abstract"=>"The endemic cichlid fishes in Lake Victoria are a model system for speciation through adaptive radiation. Although the evolution of the sex-determination system may also play a role in speciation, little is known about the sex-determination system of Lake Victoria cichlids. To understand the evolution of the sex-determination system in these fish, we performed cytogenetic analysis in 11 cichlid species from Lake Victoria. B chromosomes, which are present in addition to standard chromosomes, were found at a high prevalence rate (85%) in these cichlids. In one species, B chromosomes were female-specific. Cross-breeding using females with and without the B chromosomes demonstrated that the presence of the B chromosomes leads to a female-biased sex ratio in this species. Although B chromosomes were believed to be selfish genetic elements with little effect on phenotype and to lack protein-coding genes, the present study provides evidence that B chromosomes have a functional effect on female sex determination. FISH analysis using a BAC clone containing B chromosome DNA suggested that the B chromosomes are derived from sex chromosomes. Determination of the nucleotide sequences of this clone (104.5 kb) revealed the presence of several protein-coding genes in the B chromosome, suggesting that B chromosomes have the potential to contain functional genes. Because some sex chromosomes in amphibians and arthropods are thought to be derived from B chromosomes, the B chromosomes in Lake Victoria cichlids may represent an evolutionary transition toward the generation of sex chromosomes.", "link"=>"http://www.mendeley.com/research/b-chromosomes-functional-effect-female-sex-determination-lake-victoria-cichlid-fishes-2", "reader_count"=>50, "reader_count_by_academic_status"=>{"Researcher"=>14, "Student > Doctoral Student"=>5, "Student > Ph. D. Student"=>9, "Student > Postgraduate"=>4, "Student > Master"=>7, "Other"=>3, "Student > Bachelor"=>3, "Lecturer > Senior Lecturer"=>1, "Professor"=>4}, "reader_count_by_user_role"=>{"Researcher"=>14, "Student > Doctoral Student"=>5, "Student > Ph. D. Student"=>9, "Student > Postgraduate"=>4, "Student > Master"=>7, "Other"=>3, "Student > Bachelor"=>3, "Lecturer > Senior Lecturer"=>1, "Professor"=>4}, "reader_count_by_subject_area"=>{"Biochemistry, Genetics and Molecular Biology"=>9, "Agricultural and Biological Sciences"=>41}, "reader_count_by_subdiscipline"=>{"Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>41}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>9}}, "reader_count_by_country"=>{"Philippines"=>1, "Japan"=>1, "Serbia and Montenegro"=>1, "Brazil"=>3, "Germany"=>2}, "group_count"=>2}

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/744394"], "description"=>"<p>Scale bar, 20 km.</p>", "links"=>[], "tags"=>["localities"], "article_id"=>414752, "categories"=>["Genetics", "Evolutionary Biology"], "users"=>["Kohta Yoshida", "Yohey Terai", "Shinji Mizoiri", "Mitsuto Aibara", "Hidenori Nishihara", "Masakatsu Watanabe", "Asato Kuroiwa", "Hirohisa Hirai", "Yuriko Hirai", "Yoichi Matsuda", "Norihiro Okada"], "doi"=>"https://dx.doi.org/10.1371/journal.pgen.1002203.g001", "stats"=>{"downloads"=>0, "page_views"=>2, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Sampling_localities_in_Lake_Victoria_/414752", "title"=>"Sampling localities in Lake Victoria.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-08-18 01:19:12"}
  • {"files"=>["https://ndownloader.figshare.com/files/744803"], "description"=>"<p>(A) A pie graph showing the composition of the 104.5 kb B-BAC sequence. The percentages of genes and total repetitive sequences are indicated. (B) The copy number of the <i>ihhb</i> region as determined by real-time PCR in F2 individuals of <i>L. rubripinnis</i> from Matumbi Island population that have different numbers of B chromosomes. The mean value is shown; error bars indicate the standard deviation. (C) FISH analysis using B-BAC as a probe. The images were obtained by merging DAPI-stained patterns (blue) and the signals from the FISH probe (green). Arrowheads indicate B chromosomes. Arrows indicate chromosome 1. Scale bar, 5 µm. Since the B-BAC probe showed stronger signals than the probe using microdissected B chromosome DNA, we detected the homologous autosome region only when we used B-BAC probe.</p>", "links"=>[], "tags"=>["protein-coding", "genes", "derived", "chromosome"], "article_id"=>415168, "categories"=>["Genetics", "Evolutionary Biology"], "users"=>["Kohta Yoshida", "Yohey Terai", "Shinji Mizoiri", "Mitsuto Aibara", "Hidenori Nishihara", "Masakatsu Watanabe", "Asato Kuroiwa", "Hirohisa Hirai", "Yuriko Hirai", "Yoichi Matsuda", "Norihiro Okada"], "doi"=>"https://dx.doi.org/10.1371/journal.pgen.1002203.g005", "stats"=>{"downloads"=>0, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_The_presence_of_several_protein_coding_genes_derived_from_chromosome_1_in_B_chromosomes_/415168", "title"=>"The presence of several protein-coding genes derived from chromosome 1 in B chromosomes.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-08-18 01:26:08"}
  • {"files"=>["https://ndownloader.figshare.com/files/744577"], "description"=>"<p>(A–D) Painting FISH was carried out using the B<sub>1</sub> probe on karyotypes of wild-caught <i>L. rubripinnis</i> individuals that possess 0 (A), 1 (B), 2 (C), and 3 (D) B chromosomes. The images were obtained by merging the DAPI-stained patterns (blue) and FISH signals from the B<sub>1</sub> probe (green). Scale bar, 5 µm.</p>", "links"=>[], "tags"=>["chromosomes", "victoria", "cichlids"], "article_id"=>414942, "categories"=>["Genetics", "Evolutionary Biology"], "users"=>["Kohta Yoshida", "Yohey Terai", "Shinji Mizoiri", "Mitsuto Aibara", "Hidenori Nishihara", "Masakatsu Watanabe", "Asato Kuroiwa", "Hirohisa Hirai", "Yuriko Hirai", "Yoichi Matsuda", "Norihiro Okada"], "doi"=>"https://dx.doi.org/10.1371/journal.pgen.1002203.g003", "stats"=>{"downloads"=>0, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Demonstration_of_variation_in_the_number_of_B_chromosomes_in_Lake_Victoria_cichlids_using_painting_FISH_/414942", "title"=>"Demonstration of variation in the number of B chromosomes in Lake Victoria cichlids using painting FISH.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-08-18 01:22:22"}
  • {"files"=>["https://ndownloader.figshare.com/files/375806", "https://ndownloader.figshare.com/files/375852", "https://ndownloader.figshare.com/files/375885", "https://ndownloader.figshare.com/files/375920", "https://ndownloader.figshare.com/files/375960", "https://ndownloader.figshare.com/files/375991", "https://ndownloader.figshare.com/files/376023", "https://ndownloader.figshare.com/files/376043", "https://ndownloader.figshare.com/files/376059", "https://ndownloader.figshare.com/files/376079", "https://ndownloader.figshare.com/files/376130", "https://ndownloader.figshare.com/files/376194", "https://ndownloader.figshare.com/files/376231"], "description"=>"<div><p>The endemic cichlid fishes in Lake Victoria are a model system for speciation through adaptive radiation. Although the evolution of the sex-determination system may also play a role in speciation, little is known about the sex-determination system of Lake Victoria cichlids. To understand the evolution of the sex-determination system in these fish, we performed cytogenetic analysis in 11 cichlid species from Lake Victoria. B chromosomes, which are present in addition to standard chromosomes, were found at a high prevalence rate (85%) in these cichlids. In one species, B chromosomes were female-specific. Cross-breeding using females with and without the B chromosomes demonstrated that the presence of the B chromosomes leads to a female-biased sex ratio in this species. Although B chromosomes were believed to be selfish genetic elements with little effect on phenotype and to lack protein-coding genes, the present study provides evidence that B chromosomes have a functional effect on female sex determination. FISH analysis using a BAC clone containing B chromosome DNA suggested that the B chromosomes are derived from sex chromosomes. Determination of the nucleotide sequences of this clone (104.5 kb) revealed the presence of several protein-coding genes in the B chromosome, suggesting that B chromosomes have the potential to contain functional genes. Because some sex chromosomes in amphibians and arthropods are thought to be derived from B chromosomes, the B chromosomes in Lake Victoria cichlids may represent an evolutionary transition toward the generation of sex chromosomes.</p> </div>", "links"=>[], "tags"=>["chromosomes", "victoria", "cichlid", "fishes"], "article_id"=>134234, "categories"=>["Genetics", "Evolutionary Biology"], "users"=>["Kohta Yoshida", "Yohey Terai", "Shinji Mizoiri", "Mitsuto Aibara", "Hidenori Nishihara", "Masakatsu Watanabe", "Asato Kuroiwa", "Hirohisa Hirai", "Yuriko Hirai", "Yoichi Matsuda", "Norihiro Okada"], "doi"=>["https://dx.doi.org/10.1371/journal.pgen.1002203.s001", "https://dx.doi.org/10.1371/journal.pgen.1002203.s002", "https://dx.doi.org/10.1371/journal.pgen.1002203.s003", "https://dx.doi.org/10.1371/journal.pgen.1002203.s004", "https://dx.doi.org/10.1371/journal.pgen.1002203.s005", "https://dx.doi.org/10.1371/journal.pgen.1002203.s006", "https://dx.doi.org/10.1371/journal.pgen.1002203.s007", "https://dx.doi.org/10.1371/journal.pgen.1002203.s008", "https://dx.doi.org/10.1371/journal.pgen.1002203.s009", "https://dx.doi.org/10.1371/journal.pgen.1002203.s010", "https://dx.doi.org/10.1371/journal.pgen.1002203.s011", "https://dx.doi.org/10.1371/journal.pgen.1002203.s012", "https://dx.doi.org/10.1371/journal.pgen.1002203.s013"], "stats"=>{"downloads"=>17, "page_views"=>25, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/B_Chromosomes_Have_a_Functional_Effect_on_Female_Sex_Determination_in_Lake_Victoria_Cichlid_Fishes/134234", "title"=>"B Chromosomes Have a Functional Effect on Female Sex Determination in Lake Victoria Cichlid Fishes", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2011-08-18 01:10:34"}
  • {"files"=>["https://ndownloader.figshare.com/files/744918"], "description"=>"<p>Protein-coding genes in the B-BAC sequence.</p>", "links"=>[], "tags"=>["genes", "b-bac"], "article_id"=>415284, "categories"=>["Genetics", "Evolutionary Biology"], "users"=>["Kohta Yoshida", "Yohey Terai", "Shinji Mizoiri", "Mitsuto Aibara", "Hidenori Nishihara", "Masakatsu Watanabe", "Asato Kuroiwa", "Hirohisa Hirai", "Yuriko Hirai", "Yoichi Matsuda", "Norihiro Okada"], "doi"=>"https://dx.doi.org/10.1371/journal.pgen.1002203.t002", "stats"=>{"downloads"=>0, "page_views"=>2, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Protein_coding_genes_in_the_B_BAC_sequence_/415284", "title"=>"Protein-coding genes in the B-BAC sequence.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2011-08-18 01:28:04"}
  • {"files"=>["https://ndownloader.figshare.com/files/744473"], "description"=>"<p>(A–D) The karyotypes of individuals in one clutch of the pedigree. The larger and smaller B chromosomes are indicated as B<sub>1</sub> and B<sub>2</sub>, respectively. STT, subtelocentric and telocentric chromosomes; MSM, metacentric and submetacentric chromosomes. (E, F) FISH analysis using B<sub>1</sub> (E) and B<sub>2</sub> (F) probes on metaphase spreads from individuals of this pedigree. Arrowheads indicate B<sub>1</sub> and B<sub>2</sub> chromosomes. The FISH images were obtained by merging the DAPI-stained patterns (blue) and the signals from the FISH probes (green). Scale bar, 5 µm.</p>", "links"=>[], "tags"=>["chromosomes", "pedigree", "matumbi"], "article_id"=>414836, "categories"=>["Genetics", "Evolutionary Biology"], "users"=>["Kohta Yoshida", "Yohey Terai", "Shinji Mizoiri", "Mitsuto Aibara", "Hidenori Nishihara", "Masakatsu Watanabe", "Asato Kuroiwa", "Hirohisa Hirai", "Yuriko Hirai", "Yoichi Matsuda", "Norihiro Okada"], "doi"=>"https://dx.doi.org/10.1371/journal.pgen.1002203.g002", "stats"=>{"downloads"=>2, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_B_chromosomes_in_the_pedigree_of_L_rubripinnis_from_the_Matumbi_Island_population_/414836", "title"=>"B chromosomes in the pedigree of <i>L. rubripinnis</i> from the Matumbi Island population.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-08-18 01:20:36"}
  • {"files"=>["https://ndownloader.figshare.com/files/744886"], "description"=>"<p>Karyotypes of wild-caught individuals of Lake Victoria cichlid species.</p>", "links"=>[], "tags"=>["wild-caught", "individuals", "victoria", "cichlid"], "article_id"=>415248, "categories"=>["Genetics", "Evolutionary Biology"], "users"=>["Kohta Yoshida", "Yohey Terai", "Shinji Mizoiri", "Mitsuto Aibara", "Hidenori Nishihara", "Masakatsu Watanabe", "Asato Kuroiwa", "Hirohisa Hirai", "Yuriko Hirai", "Yoichi Matsuda", "Norihiro Okada"], "doi"=>"https://dx.doi.org/10.1371/journal.pgen.1002203.t001", "stats"=>{"downloads"=>1, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Karyotypes_of_wild_caught_individuals_of_Lake_Victoria_cichlid_species_/415248", "title"=>"Karyotypes of wild-caught individuals of Lake Victoria cichlid species.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2011-08-18 01:27:28"}
  • {"files"=>["https://ndownloader.figshare.com/files/744702"], "description"=>"<p>(A) Correlation between sex and karyotype in the wild-caught individuals and F1 and F2 individuals of <i>L. rubripinnis</i> and in offspring from cross-breeding experiments. The number below each histogram indicates the number of individuals. Asterisks indicate the significant association between B chromosomes and females of this species (Fisher's exact test: **P<0.01, *P<0.05). (B) The sex-ratio distortion induced by the presence of the female-specific B chromosome in cross-breeding families. The number of individuals that died as fry is indicated in parentheses. Statistical significance of deviation of sex ratio from 1∶1 was tested by binominal test. P-values are shown in the table below a bar graph.</p>", "links"=>[], "tags"=>["female-biased", "resulting", "female-specific", "chromosomes"], "article_id"=>415062, "categories"=>["Genetics", "Evolutionary Biology"], "users"=>["Kohta Yoshida", "Yohey Terai", "Shinji Mizoiri", "Mitsuto Aibara", "Hidenori Nishihara", "Masakatsu Watanabe", "Asato Kuroiwa", "Hirohisa Hirai", "Yuriko Hirai", "Yoichi Matsuda", "Norihiro Okada"], "doi"=>"https://dx.doi.org/10.1371/journal.pgen.1002203.g004", "stats"=>{"downloads"=>2, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_A_female_biased_sex_ratio_resulting_from_the_presence_of_female_specific_B_chromosomes_in_L_rubripinnis_/415062", "title"=>"A female-biased sex ratio resulting from the presence of female-specific B chromosomes in <i>L. rubripinnis</i>.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-08-18 01:24:22"}

PMC Usage Stats | Further Information

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Relative Metric

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