Genetic Association for Renal Traits among Participants of African Ancestry Reveals New Loci for Renal Function
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{"title"=>"Genetic association for renal traits among participants of African Ancestry reveals new loci for renal function", "type"=>"journal", "authors"=>[{"first_name"=>"Ching Ti", "last_name"=>"Liu", "scopus_author_id"=>"57191678197"}, {"first_name"=>"Maija K.", "last_name"=>"Garnaas", "scopus_author_id"=>"25622602700"}, {"first_name"=>"Adrienne", "last_name"=>"Tin", "scopus_author_id"=>"24342527900"}, {"first_name"=>"Anna", "last_name"=>"Kottgen", "scopus_author_id"=>"57194234494"}, {"first_name"=>"Nora", "last_name"=>"Franceschini", "scopus_author_id"=>"7006270916"}, {"first_name"=>"Carmen A.", "last_name"=>"Peralta", "scopus_author_id"=>"7004267461"}, {"first_name"=>"Ian H.", "last_name"=>"de Boer", "scopus_author_id"=>"6701703026"}, {"first_name"=>"Xiaoning", "last_name"=>"Lu", "scopus_author_id"=>"51461902500"}, {"first_name"=>"Elizabeth", "last_name"=>"Atkinson", "scopus_author_id"=>"27170863700"}, {"first_name"=>"Jingzhong", "last_name"=>"Ding", "scopus_author_id"=>"7402608341"}, {"first_name"=>"Michael", "last_name"=>"Nalls", "scopus_author_id"=>"55630773200"}, {"first_name"=>"Daniel", "last_name"=>"Shriner", "scopus_author_id"=>"7004202273"}, {"first_name"=>"Josef", "last_name"=>"Coresh", "scopus_author_id"=>"7005367498"}, {"first_name"=>"Abdullah", "last_name"=>"Kutlar", "scopus_author_id"=>"35462392200"}, {"first_name"=>"Kirsten", "last_name"=>"Bibbins-Domingo", "scopus_author_id"=>"6602998101"}, {"first_name"=>"David", "last_name"=>"Siscovick", "scopus_author_id"=>"7005419833"}, {"first_name"=>"Ermeg", "last_name"=>"Akylbekova", "scopus_author_id"=>"23481069300"}, {"first_name"=>"Sharon", "last_name"=>"Wyatt", "scopus_author_id"=>"10138943600"}, {"first_name"=>"Brad", "last_name"=>"Astor", "scopus_author_id"=>"6602187233"}, {"first_name"=>"Josef", "last_name"=>"Mychaleckjy", "scopus_author_id"=>"52364702700"}, {"first_name"=>"Man", "last_name"=>"Li", "scopus_author_id"=>"56953690700"}, {"first_name"=>"Muredach P.", "last_name"=>"Reilly", "scopus_author_id"=>"7202322545"}, {"first_name"=>"Raymond R.", "last_name"=>"Townsend", "scopus_author_id"=>"7202221442"}, {"first_name"=>"Adebowale", "last_name"=>"Adeyemo", "scopus_author_id"=>"56800223700"}, {"first_name"=>"Alan B.", "last_name"=>"Zonderman", "scopus_author_id"=>"56921646000"}, {"first_name"=>"Mariza", "last_name"=>"de Andrade", "scopus_author_id"=>"18334300400"}, {"first_name"=>"Stephen T.", "last_name"=>"Turner", "scopus_author_id"=>"7402275413"}, {"first_name"=>"Thomas H.", "last_name"=>"Mosley", "scopus_author_id"=>"56425717100"}, {"first_name"=>"Tamara B.", "last_name"=>"Harris", "scopus_author_id"=>"35375662400"}, {"first_name"=>"Charles N.", "last_name"=>"Rotimi", "scopus_author_id"=>"7006238725"}, {"first_name"=>"Yongmei", "last_name"=>"Liu", "scopus_author_id"=>"35435449700"}, {"first_name"=>"Sharon L.R.", "last_name"=>"Kardia", "scopus_author_id"=>"7003691206"}, {"first_name"=>"Michele K.", "last_name"=>"Evans", "scopus_author_id"=>"7404538531"}, {"first_name"=>"Michael G.", "last_name"=>"Shlipak", "scopus_author_id"=>"7005097198"}, {"first_name"=>"Holly", "last_name"=>"Kramer", "scopus_author_id"=>"56234111300"}, {"first_name"=>"Michael F.", "last_name"=>"Flessner", "scopus_author_id"=>"7005024580"}, {"first_name"=>"Albert W.", "last_name"=>"Dreisbach", "scopus_author_id"=>"56873498300"}, {"first_name"=>"Wolfram", "last_name"=>"Goessling", "scopus_author_id"=>"6603646962"}, {"first_name"=>"L. Adrienne", "last_name"=>"Cupples", "scopus_author_id"=>"7007090535"}, {"first_name"=>"W. Linda", "last_name"=>"Kao", "scopus_author_id"=>"32867884000"}, {"first_name"=>"Caroline S.", "last_name"=>"Fox", "scopus_author_id"=>"7402165524"}], "year"=>2011, "source"=>"PLoS Genetics", "identifiers"=>{"issn"=>"15537390", "isbn"=>"1553-7404; 1553-7390", "pmid"=>"21931561", "scopus"=>"2-s2.0-80053483147", "doi"=>"10.1371/journal.pgen.1002264", "sgr"=>"80053483147", "pui"=>"362683441"}, "id"=>"b7a72436-e6a3-32af-92f7-7a23e357c5b1", "abstract"=>"Chronic kidney disease (CKD) is an increasing global public health concern, particularly among populations of African ancestry. We performed an interrogation of known renal loci, genome-wide association (GWA), and IBC candidate-gene SNP association analyses in African Americans from the CARe Renal Consortium. In up to 8,110 participants, we performed meta-analyses of GWA and IBC array data for estimated glomerular filtration rate (eGFR), CKD (eGFR <60 mL/min/1.73 m(2)), urinary albumin-to-creatinine ratio (UACR), and microalbuminuria (UACR >30 mg/g) and interrogated the 250 kb flanking region around 24 SNPs previously identified in European Ancestry renal GWAS analyses. Findings were replicated in up to 4,358 African Americans. To assess function, individually identified genes were knocked down in zebrafish embryos by morpholino antisense oligonucleotides. Expression of kidney-specific genes was assessed by in situ hybridization, and glomerular filtration was evaluated by dextran clearance. Overall, 23 of 24 previously identified SNPs had direction-consistent associations with eGFR in African Americans, 2 of which achieved nominal significance (UMOD, PIP5K1B). Interrogation of the flanking regions uncovered 24 new index SNPs in African Americans, 12 of which were replicated (UMOD, ANXA9, GCKR, TFDP2, DAB2, VEGFA, ATXN2, GATM, SLC22A2, TMEM60, SLC6A13, and BCAS3). In addition, we identified 3 suggestive loci at DOK6 (p-value = 5.3×10(-7)) and FNDC1 (p-value = 3.0×10(-7)) for UACR, and KCNQ1 with eGFR (p = 3.6×10(-6)). Morpholino knockdown of kcnq1 in the zebrafish resulted in abnormal kidney development and filtration capacity. We identified several SNPs in association with eGFR in African Ancestry individuals, as well as 3 suggestive loci for UACR and eGFR. Functional genetic studies support a role for kcnq1 in glomerular development in zebrafish.", "link"=>"http://www.mendeley.com/research/genetic-association-renal-traits-among-participants-african-ancestry-reveals-new-loci-renal-function-1", "reader_count"=>40, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Professor > Associate Professor"=>4, "Student > Doctoral Student"=>2, "Researcher"=>11, "Student > Ph. D. Student"=>13, "Student > Master"=>4, "Other"=>1, "Student > Bachelor"=>3, "Professor"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Professor > Associate Professor"=>4, "Student > Doctoral Student"=>2, "Researcher"=>11, "Student > Ph. D. Student"=>13, "Student > Master"=>4, "Other"=>1, "Student > Bachelor"=>3, "Professor"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>4, "Biochemistry, Genetics and Molecular Biology"=>3, "Mathematics"=>3, "Agricultural and Biological Sciences"=>17, "Medicine and Dentistry"=>9, "Pharmacology, Toxicology and Pharmaceutical Science"=>1, "Psychology"=>2, "Computer Science"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>9}, "Psychology"=>{"Psychology"=>2}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>17}, "Computer Science"=>{"Computer Science"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>3}, "Mathematics"=>{"Mathematics"=>3}, "Unspecified"=>{"Unspecified"=>4}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>1}}, "reader_count_by_country"=>{"Spain"=>1}, "group_count"=>1}

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/372409", "https://ndownloader.figshare.com/files/372441", "https://ndownloader.figshare.com/files/372483", "https://ndownloader.figshare.com/files/372642", "https://ndownloader.figshare.com/files/372668", "https://ndownloader.figshare.com/files/372713", "https://ndownloader.figshare.com/files/372748", "https://ndownloader.figshare.com/files/372790", "https://ndownloader.figshare.com/files/372847", "https://ndownloader.figshare.com/files/372922", "https://ndownloader.figshare.com/files/372960", "https://ndownloader.figshare.com/files/373003", "https://ndownloader.figshare.com/files/373075", "https://ndownloader.figshare.com/files/373111"], "description"=>"<div><p>Chronic kidney disease (CKD) is an increasing global public health concern, particularly among populations of African ancestry. We performed an interrogation of known renal loci, genome-wide association (GWA), and IBC candidate-gene SNP association analyses in African Americans from the CARe Renal Consortium. In up to 8,110 participants, we performed meta-analyses of GWA and IBC array data for estimated glomerular filtration rate (eGFR), CKD (eGFR <60 mL/min/1.73 m<sup>2</sup>), urinary albumin-to-creatinine ratio (UACR), and microalbuminuria (UACR >30 mg/g) and interrogated the 250 kb flanking region around 24 SNPs previously identified in European Ancestry renal GWAS analyses. Findings were replicated in up to 4,358 African Americans. To assess function, individually identified genes were knocked down in zebrafish embryos by morpholino antisense oligonucleotides. Expression of kidney-specific genes was assessed by <em>in situ</em> hybridization, and glomerular filtration was evaluated by dextran clearance. Overall, 23 of 24 previously identified SNPs had direction-consistent associations with eGFR in African Americans, 2 of which achieved nominal significance (<em>UMOD</em>, <em>PIP5K1B</em>). Interrogation of the flanking regions uncovered 24 new index SNPs in African Americans, 12 of which were replicated (<em>UMOD</em>, <em>ANXA9</em>, <em>GCKR</em>, <em>TFDP2</em>, <em>DAB2</em>, <em>VEGFA</em>, <em>ATXN2</em>, <em>GATM</em>, <em>SLC22A2</em>, <em>TMEM60</em>, <em>SLC6A13</em>, and <em>BCAS3</em>). In addition, we identified 3 suggestive loci at <em>DOK6</em> (p-value = 5.3×10<sup>−7</sup>) and <em>FNDC1</em> (p-value = 3.0×10<sup>−7</sup>) for UACR, and <em>KCNQ1</em> with eGFR (p = 3.6×10<sup>−6</sup>). Morpholino knockdown of kcnq1 in the zebrafish resulted in abnormal kidney development and filtration capacity. We identified several SNPs in association with eGFR in African Ancestry individuals, as well as 3 suggestive loci for UACR and eGFR. Functional genetic studies support a role for kcnq1 in glomerular development in zebrafish.</p> </div>", "links"=>[], "tags"=>["renal", "traits", "participants", "african", "ancestry", "reveals", "loci"], "article_id"=>133541, "categories"=>["Marine Biology", "Genetics"], "users"=>["Ching-Ti Liu", "Maija K. Garnaas", "Adrienne Tin", "Anna Kottgen", "Nora Franceschini", "Carmen A. Peralta", "Ian H. de Boer", "Xiaoning Lu", "Elizabeth Atkinson", "Jingzhong Ding", "Michael Nalls", "Daniel Shriner", "Josef Coresh", "Abdullah Kutlar", "Kirsten Bibbins-Domingo", "David Siscovick", "Ermeg Akylbekova", "Sharon Wyatt", "Brad Astor", "Josef Mychaleckjy", "Man Li", "Muredach P. Reilly", "Raymond R. Townsend", "Adebowale Adeyemo", "Alan B. Zonderman", "Mariza de Andrade", "Stephen T. Turner", "Thomas H. Mosley", "Tamara B. Harris", "Charles N. Rotimi", "Yongmei Liu", "Sharon L. R. Kardia", "Michele K. Evans", "Michael G. Shlipak", "Holly Kramer", "Michael F. Flessner", "Albert W. Dreisbach", "Wolfram Goessling", "L. Adrienne Cupples", "W. Linda Kao", "Caroline S. Fox"], "doi"=>["https://dx.doi.org/10.1371/journal.pgen.1002264.s001", "https://dx.doi.org/10.1371/journal.pgen.1002264.s002", "https://dx.doi.org/10.1371/journal.pgen.1002264.s003", "https://dx.doi.org/10.1371/journal.pgen.1002264.s004", "https://dx.doi.org/10.1371/journal.pgen.1002264.s005", "https://dx.doi.org/10.1371/journal.pgen.1002264.s006", "https://dx.doi.org/10.1371/journal.pgen.1002264.s007", "https://dx.doi.org/10.1371/journal.pgen.1002264.s008", "https://dx.doi.org/10.1371/journal.pgen.1002264.s009", "https://dx.doi.org/10.1371/journal.pgen.1002264.s010", "https://dx.doi.org/10.1371/journal.pgen.1002264.s011", "https://dx.doi.org/10.1371/journal.pgen.1002264.s012", "https://dx.doi.org/10.1371/journal.pgen.1002264.s013", "https://dx.doi.org/10.1371/journal.pgen.1002264.s014"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Genetic_Association_for_Renal_Traits_among_Participants_of_African_Ancestry_Reveals_New_Loci_for_Renal_Function/133541", "title"=>"Genetic Association for Renal Traits among Participants of African Ancestry Reveals New Loci for Renal Function", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2011-09-08 00:59:01"}
  • {"files"=>["https://ndownloader.figshare.com/files/736833"], "description"=>"<p>For A) <i>DOK6</i> and B) <i>FNDC1</i>, Stage 1 only.</p>", "links"=>[], "tags"=>["plots"], "article_id"=>407142, "categories"=>["Marine Biology", "Genetics"], "users"=>["Ching-Ti Liu", "Maija K. Garnaas", "Adrienne Tin", "Anna Kottgen", "Nora Franceschini", "Carmen A. Peralta", "Ian H. de Boer", "Xiaoning Lu", "Elizabeth Atkinson", "Jingzhong Ding", "Michael Nalls", "Daniel Shriner", "Josef Coresh", "Abdullah Kutlar", "Kirsten Bibbins-Domingo", "David Siscovick", "Ermeg Akylbekova", "Sharon Wyatt", "Brad Astor", "Josef Mychaleckjy", "Man Li", "Muredach P. Reilly", "Raymond R. Townsend", "Adebowale Adeyemo", "Alan B. Zonderman", "Mariza de Andrade", "Stephen T. Turner", "Thomas H. Mosley", "Tamara B. Harris", "Charles N. Rotimi", "Yongmei Liu", "Sharon L. R. Kardia", "Michele K. Evans", "Michael G. Shlipak", "Holly Kramer", "Michael F. Flessner", "Albert W. Dreisbach", "Wolfram Goessling", "L. Adrienne Cupples", "W. Linda Kao", "Caroline S. Fox"], "doi"=>["https://dx.doi.org/10.1371/journal.pgen.1002264.g001"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Regional_association_plots_for_DOK6_and_FNDC1_/407142", "title"=>"Regional association plots for <i>DOK6 and FNDC1</i>.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-09-08 01:59:02"}
  • {"files"=>["https://ndownloader.figshare.com/files/737040"], "description"=>"<p>For A) <i>KCNQ1</i> in participants of African ancestry and B) in participants of European ancestry.</p>", "links"=>[], "tags"=>["plots"], "article_id"=>407341, "categories"=>["Marine Biology", "Genetics"], "users"=>["Ching-Ti Liu", "Maija K. Garnaas", "Adrienne Tin", "Anna Kottgen", "Nora Franceschini", "Carmen A. Peralta", "Ian H. de Boer", "Xiaoning Lu", "Elizabeth Atkinson", "Jingzhong Ding", "Michael Nalls", "Daniel Shriner", "Josef Coresh", "Abdullah Kutlar", "Kirsten Bibbins-Domingo", "David Siscovick", "Ermeg Akylbekova", "Sharon Wyatt", "Brad Astor", "Josef Mychaleckjy", "Man Li", "Muredach P. Reilly", "Raymond R. Townsend", "Adebowale Adeyemo", "Alan B. Zonderman", "Mariza de Andrade", "Stephen T. Turner", "Thomas H. Mosley", "Tamara B. Harris", "Charles N. Rotimi", "Yongmei Liu", "Sharon L. R. Kardia", "Michele K. Evans", "Michael G. Shlipak", "Holly Kramer", "Michael F. Flessner", "Albert W. Dreisbach", "Wolfram Goessling", "L. Adrienne Cupples", "W. Linda Kao", "Caroline S. Fox"], "doi"=>["https://dx.doi.org/10.1371/journal.pgen.1002264.g002"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Regional_association_plots_for_KCNQ1_/407341", "title"=>"Regional association plots for <i>KCNQ1</i>.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-09-08 02:02:21"}
  • {"files"=>["https://ndownloader.figshare.com/files/737252"], "description"=>"<p>(A–E) Zebrafish embryos injected with control morpholino show normal glomerular and tubular morphology, as shown by in situ hybridization for the global kidney marker pax2a (A, inset showing lower-magnification image, with staining in both glomerulus and tubules), the podocyte markers wt1a (B) and nephrin (C), and the proximal and distal tubular markers slc20a1a (D) and slc12a3 (E). (F–J) Injection of the kcnq1 antisense morpholino, targeting the ATG site of the gene, at the one-cell stage results in significant changes in glomerular gene expression (F–H). No changes were observed in the proximal tubule (I) or the distal tubule (J).</p>", "links"=>[], "tags"=>["knockdown", "zebrafish", "embryos", "causes", "glomerular"], "article_id"=>407543, "categories"=>["Marine Biology", "Genetics"], "users"=>["Ching-Ti Liu", "Maija K. Garnaas", "Adrienne Tin", "Anna Kottgen", "Nora Franceschini", "Carmen A. Peralta", "Ian H. de Boer", "Xiaoning Lu", "Elizabeth Atkinson", "Jingzhong Ding", "Michael Nalls", "Daniel Shriner", "Josef Coresh", "Abdullah Kutlar", "Kirsten Bibbins-Domingo", "David Siscovick", "Ermeg Akylbekova", "Sharon Wyatt", "Brad Astor", "Josef Mychaleckjy", "Man Li", "Muredach P. Reilly", "Raymond R. Townsend", "Adebowale Adeyemo", "Alan B. Zonderman", "Mariza de Andrade", "Stephen T. Turner", "Thomas H. Mosley", "Tamara B. Harris", "Charles N. Rotimi", "Yongmei Liu", "Sharon L. R. Kardia", "Michele K. Evans", "Michael G. Shlipak", "Holly Kramer", "Michael F. Flessner", "Albert W. Dreisbach", "Wolfram Goessling", "L. Adrienne Cupples", "W. Linda Kao", "Caroline S. Fox"], "doi"=>["https://dx.doi.org/10.1371/journal.pgen.1002264.g003"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Kcnq1_knockdown_in_zebrafish_embryos_causes_glomerular_abnormalities_/407543", "title"=>"Kcnq1 knockdown in zebrafish embryos causes glomerular abnormalities.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-09-08 02:05:43"}
  • {"files"=>["https://ndownloader.figshare.com/files/737451"], "description"=>"<p>Embryos were subsequently injected in the sinus venosus with 10,000 MW rhodamine dextran at 48 hpf. Dextran clearance was monitored over the next 48 hours by confocal microscopy. Compared to control MO-injected embryos (A–C), kcnq1 MO-injected embryos exhibit edema (D, E) and increased dextran clearance (F) 48 hours post-injection (hpi), suggestive of a filtration defect. At 5 dpf, 87% of kcnq1 morphant embryos (n = 38) develop edema (G).</p>", "links"=>[], "tags"=>["embryos", "injected", "200", "um", "kcnq1", "morpholino", "1-cell"], "article_id"=>407744, "categories"=>["Marine Biology", "Genetics"], "users"=>["Ching-Ti Liu", "Maija K. Garnaas", "Adrienne Tin", "Anna Kottgen", "Nora Franceschini", "Carmen A. Peralta", "Ian H. de Boer", "Xiaoning Lu", "Elizabeth Atkinson", "Jingzhong Ding", "Michael Nalls", "Daniel Shriner", "Josef Coresh", "Abdullah Kutlar", "Kirsten Bibbins-Domingo", "David Siscovick", "Ermeg Akylbekova", "Sharon Wyatt", "Brad Astor", "Josef Mychaleckjy", "Man Li", "Muredach P. Reilly", "Raymond R. Townsend", "Adebowale Adeyemo", "Alan B. Zonderman", "Mariza de Andrade", "Stephen T. Turner", "Thomas H. Mosley", "Tamara B. Harris", "Charles N. Rotimi", "Yongmei Liu", "Sharon L. R. Kardia", "Michele K. Evans", "Michael G. Shlipak", "Holly Kramer", "Michael F. Flessner", "Albert W. Dreisbach", "Wolfram Goessling", "L. Adrienne Cupples", "W. Linda Kao", "Caroline S. Fox"], "doi"=>["https://dx.doi.org/10.1371/journal.pgen.1002264.g004"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Tg_cdh17_GFP_embryos_were_injected_with_200_uM_control_or_kcnq1_morpholino_MO_at_the_1_cell_stage_/407744", "title"=>"<i>Tg(cdh17:GFP)</i> embryos were injected with 200 uM control or kcnq1 morpholino (MO) at the 1-cell stage.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-09-08 02:09:04"}
  • {"files"=>["https://ndownloader.figshare.com/files/737584"], "description"=>"<p>*Control or Uninjected versus splice MO.</p><p>**Control or Uninjected versus ATG MO.</p>", "links"=>[], "tags"=>["observed", "embryos", "examined", "200", "um", "injection", "400"], "article_id"=>407876, "categories"=>["Marine Biology", "Genetics"], "users"=>["Ching-Ti Liu", "Maija K. Garnaas", "Adrienne Tin", "Anna Kottgen", "Nora Franceschini", "Carmen A. Peralta", "Ian H. de Boer", "Xiaoning Lu", "Elizabeth Atkinson", "Jingzhong Ding", "Michael Nalls", "Daniel Shriner", "Josef Coresh", "Abdullah Kutlar", "Kirsten Bibbins-Domingo", "David Siscovick", "Ermeg Akylbekova", "Sharon Wyatt", "Brad Astor", "Josef Mychaleckjy", "Man Li", "Muredach P. Reilly", "Raymond R. Townsend", "Adebowale Adeyemo", "Alan B. Zonderman", "Mariza de Andrade", "Stephen T. Turner", "Thomas H. Mosley", "Tamara B. Harris", "Charles N. Rotimi", "Yongmei Liu", "Sharon L. R. Kardia", "Michele K. Evans", "Michael G. Shlipak", "Holly Kramer", "Michael F. Flessner", "Albert W. Dreisbach", "Wolfram Goessling", "L. Adrienne Cupples", "W. Linda Kao", "Caroline S. Fox"], "doi"=>["https://dx.doi.org/10.1371/journal.pgen.1002264.t005"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Number_of_observed_abnormalities_number_of_embryos_examined_at_200_uM_injection_kcnq1_and_400_uM_injection_dok6_and_fndc1_/407876", "title"=>"Number of observed abnormalities/number of embryos examined at 200 uM injection (kcnq1) and 400 uM injection (dok6 and fndc1).", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2011-09-08 02:11:16"}
  • {"files"=>["https://ndownloader.figshare.com/files/737677"], "description"=>"<p>Stage 1 and Stage 2 results from loci in African Americans from GWAS (p<5.0*10E-06): SNP association with renal traits.</p>", "links"=>[], "tags"=>["loci", "african", "americans", "GWAS", "snp", "renal"], "article_id"=>407972, "categories"=>["Marine Biology", "Genetics"], "users"=>["Ching-Ti Liu", "Maija K. Garnaas", "Adrienne Tin", "Anna Kottgen", "Nora Franceschini", "Carmen A. Peralta", "Ian H. de Boer", "Xiaoning Lu", "Elizabeth Atkinson", "Jingzhong Ding", "Michael Nalls", "Daniel Shriner", "Josef Coresh", "Abdullah Kutlar", "Kirsten Bibbins-Domingo", "David Siscovick", "Ermeg Akylbekova", "Sharon Wyatt", "Brad Astor", "Josef Mychaleckjy", "Man Li", "Muredach P. Reilly", "Raymond R. Townsend", "Adebowale Adeyemo", "Alan B. Zonderman", "Mariza de Andrade", "Stephen T. Turner", "Thomas H. Mosley", "Tamara B. Harris", "Charles N. Rotimi", "Yongmei Liu", "Sharon L. R. Kardia", "Michele K. Evans", "Michael G. Shlipak", "Holly Kramer", "Michael F. Flessner", "Albert W. Dreisbach", "Wolfram Goessling", "L. Adrienne Cupples", "W. Linda Kao", "Caroline S. Fox"], "doi"=>["https://dx.doi.org/10.1371/journal.pgen.1002264.t004"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Stage_1_and_Stage_2_results_from_loci_in_African_Americans_from_GWAS_p_lt_5_0_10E_06_SNP_association_with_renal_traits_/407972", "title"=>"Stage 1 and Stage 2 results from loci in African Americans from GWAS (p<5.0*10E-06): SNP association with renal traits.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2011-09-08 02:12:52"}
  • {"files"=>["https://ndownloader.figshare.com/files/737786"], "description"=>"<p>Interrogation of known loci in EA in AA for the trait eGFRcrea; best SNP at each locus is shown below; SNP ID in bold from Kottgen et al, Nature Genetics 2009, and Nature Genetics 2010.</p>", "links"=>[], "tags"=>["loci", "ea", "aa", "snp", "locus", "shown", "id", "kottgen", "et", "genetics"], "article_id"=>408068, "categories"=>["Marine Biology", "Genetics"], "users"=>["Ching-Ti Liu", "Maija K. Garnaas", "Adrienne Tin", "Anna Kottgen", "Nora Franceschini", "Carmen A. Peralta", "Ian H. de Boer", "Xiaoning Lu", "Elizabeth Atkinson", "Jingzhong Ding", "Michael Nalls", "Daniel Shriner", "Josef Coresh", "Abdullah Kutlar", "Kirsten Bibbins-Domingo", "David Siscovick", "Ermeg Akylbekova", "Sharon Wyatt", "Brad Astor", "Josef Mychaleckjy", "Man Li", "Muredach P. Reilly", "Raymond R. Townsend", "Adebowale Adeyemo", "Alan B. Zonderman", "Mariza de Andrade", "Stephen T. Turner", "Thomas H. Mosley", "Tamara B. Harris", "Charles N. Rotimi", "Yongmei Liu", "Sharon L. R. Kardia", "Michele K. Evans", "Michael G. Shlipak", "Holly Kramer", "Michael F. Flessner", "Albert W. Dreisbach", "Wolfram Goessling", "L. Adrienne Cupples", "W. Linda Kao", "Caroline S. Fox"], "doi"=>["https://dx.doi.org/10.1371/journal.pgen.1002264.t003"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Interrogation_of_known_loci_in_EA_in_AA_for_the_trait_eGFRcrea_best_SNP_at_each_locus_is_shown_below_SNP_ID_in_bold_from_Kottgen_et_al_Nature_Genetics_2009_and_Nature_Genetics_2010_/408068", "title"=>"Interrogation of known loci in EA in AA for the trait eGFRcrea; best SNP at each locus is shown below; SNP ID in bold from Kottgen et al, Nature Genetics 2009, and Nature Genetics 2010.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2011-09-08 02:14:28"}
  • {"files"=>["https://ndownloader.figshare.com/files/737889"], "description"=>"<p>* Lead SNP rs12917707 in EA not present in AA dataset; therefore used rs4293393, which is in perfect LD in EA (r2 = 1.0).</p><p>** rs2279463 not present in AA dataset.</p>", "links"=>[], "tags"=>["loci", "ea", "aa", "snp", "locus", "shown", "id", "kottgen", "et", "genetics"], "article_id"=>408185, "categories"=>["Marine Biology", "Genetics"], "users"=>["Ching-Ti Liu", "Maija K. Garnaas", "Adrienne Tin", "Anna Kottgen", "Nora Franceschini", "Carmen A. Peralta", "Ian H. de Boer", "Xiaoning Lu", "Elizabeth Atkinson", "Jingzhong Ding", "Michael Nalls", "Daniel Shriner", "Josef Coresh", "Abdullah Kutlar", "Kirsten Bibbins-Domingo", "David Siscovick", "Ermeg Akylbekova", "Sharon Wyatt", "Brad Astor", "Josef Mychaleckjy", "Man Li", "Muredach P. Reilly", "Raymond R. Townsend", "Adebowale Adeyemo", "Alan B. Zonderman", "Mariza de Andrade", "Stephen T. Turner", "Thomas H. Mosley", "Tamara B. Harris", "Charles N. Rotimi", "Yongmei Liu", "Sharon L. R. Kardia", "Michele K. Evans", "Michael G. Shlipak", "Holly Kramer", "Michael F. Flessner", "Albert W. Dreisbach", "Wolfram Goessling", "L. Adrienne Cupples", "W. Linda Kao", "Caroline S. Fox"], "doi"=>["https://dx.doi.org/10.1371/journal.pgen.1002264.t002"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Interrogation_of_known_loci_in_EA_in_AA_for_the_trait_eGFRcrea_best_SNP_at_each_locus_is_shown_below_SNP_ID_in_bold_from_Kottgen_et_al_Nature_Genetics_2009_and_Nature_Genetics_2010_/408185", "title"=>"Interrogation of known loci in EA in AA for the trait eGFRcrea; best SNP at each locus is shown below; SNP ID in bold from Kottgen et al, Nature Genetics 2009, and Nature Genetics 2010.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2011-09-08 02:16:25"}
  • {"files"=>["https://ndownloader.figshare.com/files/737985"], "description"=>"<p>Abbreviations: eGFRcrea: estimated glomerular filtration rate by serum creatinine, eGFRcys: estimated glomerular filtration rate by serum cystatin C, CKD: chronic kidney disease, HTN: hypertension, DM: diabetes mellitus, NA: not available.</p><p>* Sample characteristics based on the larger eGFR sample.</p><p>** CHS only has data on the IBC platform.</p><p>§ Median, 25/75<sup>th</sup> percentile.</p>", "links"=>[], "tags"=>["characteristics", "renal"], "article_id"=>408287, "categories"=>["Marine Biology", "Genetics"], "users"=>["Ching-Ti Liu", "Maija K. Garnaas", "Adrienne Tin", "Anna Kottgen", "Nora Franceschini", "Carmen A. Peralta", "Ian H. de Boer", "Xiaoning Lu", "Elizabeth Atkinson", "Jingzhong Ding", "Michael Nalls", "Daniel Shriner", "Josef Coresh", "Abdullah Kutlar", "Kirsten Bibbins-Domingo", "David Siscovick", "Ermeg Akylbekova", "Sharon Wyatt", "Brad Astor", "Josef Mychaleckjy", "Man Li", "Muredach P. Reilly", "Raymond R. Townsend", "Adebowale Adeyemo", "Alan B. Zonderman", "Mariza de Andrade", "Stephen T. Turner", "Thomas H. Mosley", "Tamara B. Harris", "Charles N. Rotimi", "Yongmei Liu", "Sharon L. R. Kardia", "Michele K. Evans", "Michael G. Shlipak", "Holly Kramer", "Michael F. Flessner", "Albert W. Dreisbach", "Wolfram Goessling", "L. Adrienne Cupples", "W. Linda Kao", "Caroline S. Fox"], "doi"=>["https://dx.doi.org/10.1371/journal.pgen.1002264.t001"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Study_sample_characteristics_in_the_CARE_Renal_Consortium_/408287", "title"=>"Study sample characteristics in the CARE Renal Consortium.<sup>*</sup>", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2011-09-08 02:18:07"}

PMC Usage Stats | Further Information

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  • {"unique-ip"=>"14", "full-text"=>"22", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"6", "cited-by"=>"0", "year"=>"2018", "month"=>"9"}
  • {"unique-ip"=>"12", "full-text"=>"16", "pdf"=>"6", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"8", "cited-by"=>"0", "year"=>"2018", "month"=>"11"}
  • {"unique-ip"=>"16", "full-text"=>"15", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"7", "cited-by"=>"0", "year"=>"2018", "month"=>"12"}
  • {"unique-ip"=>"21", "full-text"=>"24", "pdf"=>"8", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"43", "cited-by"=>"0", "year"=>"2019", "month"=>"2"}
  • {"unique-ip"=>"5", "full-text"=>"3", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"3"}
  • {"unique-ip"=>"15", "full-text"=>"20", "pdf"=>"17", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2019", "month"=>"4"}
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Relative Metric

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