Association of NCF2, IKZF1, IRF8, IFIH1, and TYK2 with Systemic Lupus Erythematosus
Publication Date
October 27, 2011
Journal
PLOS Genetics
Authors
Deborah S. Cunninghame Graham, David L. Morris, Tushar R. Bhangale, Lindsey A. Criswell, et al
Volume
7
Issue
10
Pages
e1002341
DOI
https://dx.plos.org/10.1371/journal.pgen.1002341
Publisher URL
http://journals.plos.org/plosgenetics/article?id=10.1371%2Fjournal.pgen.1002341
PubMed
http://www.ncbi.nlm.nih.gov/pubmed/22046141
PubMed Central
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3203198
Europe PMC
http://europepmc.org/abstract/MED/22046141
Web of Science
000296665400040
Scopus
80055080962
Mendeley
http://www.mendeley.com/research/association-ncf2-ikzf1-irf8-ifih1-tyk2-systemic-lupus-erythematosus
Events
Loading … Spinner

Mendeley | Further Information

{"title"=>"Association of NCF2, IKZF1, IRF8, IFIH1, and TYK2 with systemic lupus erythematosus", "type"=>"journal", "authors"=>[{"first_name"=>"Deborah S.", "last_name"=>"Graham", "scopus_author_id"=>"57193701296"}, {"first_name"=>"David L.", "last_name"=>"Morris", "scopus_author_id"=>"56291337200"}, {"first_name"=>"Tushar R.", "last_name"=>"Bhangale", "scopus_author_id"=>"8757096600"}, {"first_name"=>"Lindsey A.", "last_name"=>"Criswell", "scopus_author_id"=>"54790563400"}, {"first_name"=>"Ann Christine", "last_name"=>"Syvänen", "scopus_author_id"=>"7005911199"}, {"first_name"=>"Lars", "last_name"=>"Rönnblom", "scopus_author_id"=>"7004565517"}, {"first_name"=>"Timothy W.", "last_name"=>"Behrens", "scopus_author_id"=>"7005294636"}, {"first_name"=>"Robert R.", "last_name"=>"Graham", "scopus_author_id"=>"7401483388"}, {"first_name"=>"Timothy J.", "last_name"=>"Vyse", "scopus_author_id"=>"7003955999"}], "year"=>2011, "source"=>"PLoS Genetics", "identifiers"=>{"issn"=>"15537390", "pui"=>"362834376", "doi"=>"10.1371/journal.pgen.1002341", "sgr"=>"80055080962", "scopus"=>"2-s2.0-80055080962", "isbn"=>"1553-7404 (Electronic)\\r1553-7390 (Linking)", "pmid"=>"22046141"}, "id"=>"07f0891e-295c-36a3-8b06-f0e203d051e8", "abstract"=>"Systemic lupus erythematosus (SLE) is a complex trait characterised by the production of a range of auto-antibodies and a diverse set of clinical phenotypes. Currently, ~8% of the genetic contribution to SLE in Europeans is known, following publication of several moderate-sized genome-wide (GW) association studies, which identified loci with a strong effect (OR>1.3). In order to identify additional genes contributing to SLE susceptibility, we conducted a replication study in a UK dataset (870 cases, 5,551 controls) of 23 variants that showed moderate-risk for lupus in previous studies. Association analysis in the UK dataset and subsequent meta-analysis with the published data identified five SLE susceptibility genes reaching genome-wide levels of significance (P(comb)<5×10(-8)): NCF2 (P(comb) = 2.87×10(-11)), IKZF1 (P(comb) = 2.33×10(-9)), IRF8 (P(comb) = 1.24×10(-8)), IFIH1 (P(comb) = 1.63×10(-8)), and TYK2 (P(comb) = 3.88×10(-8)). Each of the five new loci identified here can be mapped into interferon signalling pathways, which are known to play a key role in the pathogenesis of SLE. These results increase the number of established susceptibility genes for lupus to ~30 and validate the importance of using large datasets to confirm associations of loci which moderately increase the risk for disease.", "link"=>"http://www.mendeley.com/research/association-ncf2-ikzf1-irf8-ifih1-tyk2-systemic-lupus-erythematosus", "reader_count"=>67, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>2, "Student > Doctoral Student"=>5, "Researcher"=>16, "Student > Ph. D. Student"=>19, "Student > Postgraduate"=>5, "Other"=>4, "Student > Master"=>10, "Student > Bachelor"=>2, "Professor"=>4}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>2, "Student > Doctoral Student"=>5, "Researcher"=>16, "Student > Ph. D. Student"=>19, "Student > Postgraduate"=>5, "Other"=>4, "Student > Master"=>10, "Student > Bachelor"=>2, "Professor"=>4}, "reader_count_by_subject_area"=>{"Unspecified"=>2, "Biochemistry, Genetics and Molecular Biology"=>10, "Mathematics"=>1, "Agricultural and Biological Sciences"=>32, "Medicine and Dentistry"=>16, "Neuroscience"=>2, "Immunology and Microbiology"=>4}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>16}, "Neuroscience"=>{"Neuroscience"=>2}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>4}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>32}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>10}, "Mathematics"=>{"Mathematics"=>1}, "Unspecified"=>{"Unspecified"=>2}}, "reader_count_by_country"=>{"Norway"=>1}, "group_count"=>4}

CrossRef

Scopus | Further Information

{"@_fa"=>"true", "link"=>[{"@_fa"=>"true", "@ref"=>"self", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/80055080962"}, {"@_fa"=>"true", "@ref"=>"author-affiliation", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/80055080962?field=author,affiliation"}, {"@_fa"=>"true", "@ref"=>"scopus", "@href"=>"https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=80055080962&origin=inward"}, {"@_fa"=>"true", "@ref"=>"scopus-citedby", "@href"=>"https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=80055080962&origin=inward"}], "prism:url"=>"https://api.elsevier.com/content/abstract/scopus_id/80055080962", "dc:identifier"=>"SCOPUS_ID:80055080962", "eid"=>"2-s2.0-80055080962", "dc:title"=>"Association of NCF2, IKZF1, IRF8, IFIH1, and TYK2 with systemic lupus erythematosus", "dc:creator"=>"Graham D.S.", "prism:publicationName"=>"PLoS Genetics", "prism:issn"=>"15537390", "prism:eIssn"=>"15537404", "prism:volume"=>"7", "prism:issueIdentifier"=>"10", "prism:pageRange"=>nil, "prism:coverDate"=>"2011-10-01", "prism:coverDisplayDate"=>"October 2011", "prism:doi"=>"10.1371/journal.pgen.1002341", "citedby-count"=>"180", "affiliation"=>[{"@_fa"=>"true", "affilname"=>"Faculty of Life Sciences &amp; Medicine", "affiliation-city"=>"London", "affiliation-country"=>"United Kingdom"}], "pubmed-id"=>"22046141", "prism:aggregationType"=>"Journal", "subtype"=>"ar", "subtypeDescription"=>"Article", "article-number"=>"e1002341", "source-id"=>"4000151808", "openaccess"=>"1", "openaccessFlag"=>true}

Facebook

  • {"url"=>"http%3A%2F%2Fjournals.plos.org%2Fplosgenetics%2Farticle%3Fid%3D10.1371%252Fjournal.pgen.1002341", "share_count"=>0, "like_count"=>0, "comment_count"=>0, "click_count"=>0, "total_count"=>0}

Counter

  • {"month"=>"10", "year"=>"2011", "pdf_views"=>"63", "xml_views"=>"1", "html_views"=>"443"}
  • {"month"=>"11", "year"=>"2011", "pdf_views"=>"142", "xml_views"=>"14", "html_views"=>"716"}
  • {"month"=>"12", "year"=>"2011", "pdf_views"=>"44", "xml_views"=>"0", "html_views"=>"149"}
  • {"month"=>"1", "year"=>"2012", "pdf_views"=>"54", "xml_views"=>"0", "html_views"=>"128"}
  • {"month"=>"2", "year"=>"2012", "pdf_views"=>"51", "xml_views"=>"1", "html_views"=>"107"}
  • {"month"=>"3", "year"=>"2012", "pdf_views"=>"38", "xml_views"=>"0", "html_views"=>"75"}
  • {"month"=>"4", "year"=>"2012", "pdf_views"=>"32", "xml_views"=>"1", "html_views"=>"96"}
  • {"month"=>"5", "year"=>"2012", "pdf_views"=>"32", "xml_views"=>"0", "html_views"=>"88"}
  • {"month"=>"6", "year"=>"2012", "pdf_views"=>"38", "xml_views"=>"2", "html_views"=>"92"}
  • {"month"=>"7", "year"=>"2012", "pdf_views"=>"19", "xml_views"=>"0", "html_views"=>"77"}
  • {"month"=>"8", "year"=>"2012", "pdf_views"=>"23", "xml_views"=>"6", "html_views"=>"106"}
  • {"month"=>"9", "year"=>"2012", "pdf_views"=>"25", "xml_views"=>"0", "html_views"=>"82"}
  • {"month"=>"10", "year"=>"2012", "pdf_views"=>"23", "xml_views"=>"1", "html_views"=>"101"}
  • {"month"=>"11", "year"=>"2012", "pdf_views"=>"21", "xml_views"=>"0", "html_views"=>"93"}
  • {"month"=>"12", "year"=>"2012", "pdf_views"=>"15", "xml_views"=>"0", "html_views"=>"48"}
  • {"month"=>"1", "year"=>"2013", "pdf_views"=>"14", "xml_views"=>"0", "html_views"=>"68"}
  • {"month"=>"2", "year"=>"2013", "pdf_views"=>"7", "xml_views"=>"2", "html_views"=>"189"}
  • {"month"=>"3", "year"=>"2013", "pdf_views"=>"20", "xml_views"=>"0", "html_views"=>"84"}
  • {"month"=>"4", "year"=>"2013", "pdf_views"=>"18", "xml_views"=>"0", "html_views"=>"62"}
  • {"month"=>"5", "year"=>"2013", "pdf_views"=>"19", "xml_views"=>"0", "html_views"=>"56"}
  • {"month"=>"6", "year"=>"2013", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"53"}
  • {"month"=>"7", "year"=>"2013", "pdf_views"=>"14", "xml_views"=>"0", "html_views"=>"62"}
  • {"month"=>"8", "year"=>"2013", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"58"}
  • {"month"=>"9", "year"=>"2013", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"39"}
  • {"month"=>"10", "year"=>"2013", "pdf_views"=>"15", "xml_views"=>"1", "html_views"=>"87"}
  • {"month"=>"11", "year"=>"2013", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"62"}
  • {"month"=>"12", "year"=>"2013", "pdf_views"=>"5", "xml_views"=>"1", "html_views"=>"56"}
  • {"month"=>"1", "year"=>"2014", "pdf_views"=>"18", "xml_views"=>"1", "html_views"=>"65"}
  • {"month"=>"2", "year"=>"2014", "pdf_views"=>"16", "xml_views"=>"0", "html_views"=>"74"}
  • {"month"=>"3", "year"=>"2014", "pdf_views"=>"20", "xml_views"=>"2", "html_views"=>"102"}
  • {"month"=>"4", "year"=>"2014", "pdf_views"=>"12", "xml_views"=>"1", "html_views"=>"77"}
  • {"month"=>"5", "year"=>"2014", "pdf_views"=>"16", "xml_views"=>"0", "html_views"=>"55"}
  • {"month"=>"6", "year"=>"2014", "pdf_views"=>"11", "xml_views"=>"1", "html_views"=>"71"}
  • {"month"=>"7", "year"=>"2014", "pdf_views"=>"15", "xml_views"=>"0", "html_views"=>"87"}
  • {"month"=>"8", "year"=>"2014", "pdf_views"=>"6", "xml_views"=>"2", "html_views"=>"38"}
  • {"month"=>"9", "year"=>"2014", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"50"}
  • {"month"=>"10", "year"=>"2014", "pdf_views"=>"7", "xml_views"=>"2", "html_views"=>"64"}
  • {"month"=>"11", "year"=>"2014", "pdf_views"=>"5", "xml_views"=>"2", "html_views"=>"55"}
  • {"month"=>"12", "year"=>"2014", "pdf_views"=>"10", "xml_views"=>"2", "html_views"=>"55"}
  • {"month"=>"1", "year"=>"2015", "pdf_views"=>"14", "xml_views"=>"0", "html_views"=>"65"}
  • {"month"=>"2", "year"=>"2015", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"29"}
  • {"month"=>"3", "year"=>"2015", "pdf_views"=>"9", "xml_views"=>"1", "html_views"=>"24"}
  • {"month"=>"4", "year"=>"2015", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"37"}
  • {"month"=>"5", "year"=>"2015", "pdf_views"=>"10", "xml_views"=>"1", "html_views"=>"54"}
  • {"month"=>"6", "year"=>"2015", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"48"}
  • {"month"=>"7", "year"=>"2015", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"42"}
  • {"month"=>"8", "year"=>"2015", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"41"}
  • {"month"=>"9", "year"=>"2015", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"54"}
  • {"month"=>"10", "year"=>"2015", "pdf_views"=>"14", "xml_views"=>"0", "html_views"=>"53"}
  • {"month"=>"11", "year"=>"2015", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"39"}
  • {"month"=>"12", "year"=>"2015", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"54"}
  • {"month"=>"1", "year"=>"2016", "pdf_views"=>"15", "xml_views"=>"1", "html_views"=>"56"}
  • {"month"=>"2", "year"=>"2016", "pdf_views"=>"15", "xml_views"=>"0", "html_views"=>"69"}
  • {"month"=>"3", "year"=>"2016", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"58"}
  • {"month"=>"4", "year"=>"2016", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"50"}
  • {"month"=>"5", "year"=>"2016", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"58"}
  • {"month"=>"6", "year"=>"2016", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"37"}
  • {"month"=>"7", "year"=>"2016", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"29"}
  • {"month"=>"8", "year"=>"2016", "pdf_views"=>"19", "xml_views"=>"0", "html_views"=>"48"}
  • {"month"=>"9", "year"=>"2016", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"61"}
  • {"month"=>"10", "year"=>"2016", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"39"}
  • {"month"=>"11", "year"=>"2016", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"59"}
  • {"month"=>"12", "year"=>"2016", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"33"}
  • {"month"=>"1", "year"=>"2017", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"44"}
  • {"month"=>"2", "year"=>"2017", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"60"}
  • {"month"=>"3", "year"=>"2017", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"34"}
  • {"month"=>"4", "year"=>"2017", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"53"}
  • {"month"=>"5", "year"=>"2017", "pdf_views"=>"13", "xml_views"=>"1", "html_views"=>"64"}
  • {"month"=>"6", "year"=>"2017", "pdf_views"=>"12", "xml_views"=>"1", "html_views"=>"56"}
  • {"month"=>"7", "year"=>"2017", "pdf_views"=>"8", "xml_views"=>"1", "html_views"=>"51"}
  • {"month"=>"8", "year"=>"2017", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"39"}
  • {"month"=>"9", "year"=>"2017", "pdf_views"=>"5", "xml_views"=>"1", "html_views"=>"25"}
  • {"month"=>"10", "year"=>"2017", "pdf_views"=>"9", "xml_views"=>"2", "html_views"=>"35"}
  • {"month"=>"11", "year"=>"2017", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"49"}
  • {"month"=>"12", "year"=>"2017", "pdf_views"=>"4", "xml_views"=>"1", "html_views"=>"31"}
  • {"month"=>"1", "year"=>"2018", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"31"}
  • {"month"=>"2", "year"=>"2018", "pdf_views"=>"12", "xml_views"=>"1", "html_views"=>"19"}
  • {"month"=>"3", "year"=>"2018", "pdf_views"=>"16", "xml_views"=>"0", "html_views"=>"18"}
  • {"month"=>"4", "year"=>"2018", "pdf_views"=>"10", "xml_views"=>"2", "html_views"=>"20"}
  • {"month"=>"5", "year"=>"2018", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"15"}
  • {"month"=>"6", "year"=>"2018", "pdf_views"=>"30", "xml_views"=>"0", "html_views"=>"13"}
  • {"month"=>"7", "year"=>"2018", "pdf_views"=>"14", "xml_views"=>"4", "html_views"=>"22"}
  • {"month"=>"8", "year"=>"2018", "pdf_views"=>"2", "xml_views"=>"1", "html_views"=>"14"}
  • {"month"=>"9", "year"=>"2018", "pdf_views"=>"12", "xml_views"=>"1", "html_views"=>"16"}
  • {"month"=>"10", "year"=>"2018", "pdf_views"=>"5", "xml_views"=>"1", "html_views"=>"22"}
  • {"month"=>"11", "year"=>"2018", "pdf_views"=>"0", "xml_views"=>"0", "html_views"=>"11"}
  • {"month"=>"12", "year"=>"2018", "pdf_views"=>"9", "xml_views"=>"2", "html_views"=>"20"}
  • {"month"=>"1", "year"=>"2019", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"11"}
  • {"month"=>"2", "year"=>"2019", "pdf_views"=>"14", "xml_views"=>"1", "html_views"=>"35"}
  • {"month"=>"3", "year"=>"2019", "pdf_views"=>"12", "xml_views"=>"1", "html_views"=>"12"}
  • {"month"=>"4", "year"=>"2019", "pdf_views"=>"15", "xml_views"=>"0", "html_views"=>"35"}
  • {"month"=>"5", "year"=>"2019", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"25"}
  • {"month"=>"6", "year"=>"2019", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"22"}
  • {"month"=>"7", "year"=>"2019", "pdf_views"=>"16", "xml_views"=>"0", "html_views"=>"14"}
  • {"month"=>"8", "year"=>"2019", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"13"}
  • {"month"=>"9", "year"=>"2019", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"19"}
  • {"month"=>"10", "year"=>"2019", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"16"}
  • {"month"=>"11", "year"=>"2019", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"20"}
  • {"month"=>"12", "year"=>"2019", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"10"}
  • {"month"=>"1", "year"=>"2020", "pdf_views"=>"18", "xml_views"=>"1", "html_views"=>"15"}
  • {"month"=>"2", "year"=>"2020", "pdf_views"=>"8", "xml_views"=>"1", "html_views"=>"9"}
  • {"month"=>"3", "year"=>"2020", "pdf_views"=>"8", "xml_views"=>"1", "html_views"=>"13"}
  • {"month"=>"4", "year"=>"2020", "pdf_views"=>"18", "xml_views"=>"1", "html_views"=>"10"}
  • {"month"=>"5", "year"=>"2020", "pdf_views"=>"19", "xml_views"=>"0", "html_views"=>"11"}
  • {"month"=>"6", "year"=>"2020", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"7"}
  • {"month"=>"7", "year"=>"2020", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"13"}
  • {"month"=>"8", "year"=>"2020", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"26"}
  • {"month"=>"9", "year"=>"2020", "pdf_views"=>"16", "xml_views"=>"0", "html_views"=>"24"}
  • {"month"=>"10", "year"=>"2020", "pdf_views"=>"33", "xml_views"=>"0", "html_views"=>"14"}

Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/718934"], "description"=>"a<p>For sample numbers see reference <a href=\"http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1002341#pgen.1002341-Gateva1\" target=\"_blank\">[4]</a> and <a href=\"http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1002341#pgen.1002341.s004\" target=\"_blank\">Table S1</a> (US GWAS: 1310 cases and 7859 controls; US replication cohort: 1129 cases and 2991 controls; Swedish replication cohort: 834 cases and 1388 controls).</p>b<p>The risk allele frequency was calculated in control individuals.</p>", "links"=>[], "tags"=>["snps", "sle", "swedish"], "article_id"=>389283, "categories"=>["Ecology", "Genetics", "Immunology"], "users"=>["Deborah S. Cunninghame Graham", "David L. Morris", "Tushar R. Bhangale", "Lindsey A. Criswell", "Ann-Christine Syvänen", "Lars Rönnblom", "Timothy W. Behrens", "Robert R. Graham", "Timothy J. Vyse"], "doi"=>"https://dx.doi.org/10.1371/journal.pgen.1002341.t003", "stats"=>{"downloads"=>0, "page_views"=>2, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Additional_SNPs_showing_association_with_SLE_in_the_UK_US_and_Swedish_cohorts_/389283", "title"=>"Additional SNPs showing association with SLE in the UK, US, and Swedish cohorts.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2011-10-27 02:34:43"}
  • {"files"=>["https://ndownloader.figshare.com/files/718725"], "description"=>"<p>The figure shows the interferon-related pathways involving <i>NCF2</i>, <i>IKZF1</i>, <i>IRF8</i>, <i>IFIH1</i> and <i>TYK2</i> and and the ways in which these pathways may contribute to lupus susceptibility. In SLE these five genes contribute to increasing the levels of type-I and –II interferons, imbalances in Th1/Th2 related to disease severity, perturbations in B cell physiology and production of a diverse set of auto-antibodies.</p>", "links"=>[], "tags"=>["immuno-dysregulation", "susceptibility", "genes"], "article_id"=>389076, "categories"=>["Ecology", "Genetics", "Immunology"], "users"=>["Deborah S. Cunninghame Graham", "David L. Morris", "Tushar R. Bhangale", "Lindsey A. Criswell", "Ann-Christine Syvänen", "Lars Rönnblom", "Timothy W. Behrens", "Robert R. Graham", "Timothy J. Vyse"], "doi"=>"https://dx.doi.org/10.1371/journal.pgen.1002341.g001", "stats"=>{"downloads"=>1, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Pathways_of_immuno_dysregulation_by_five_new_susceptibility_genes_for_SLE_/389076", "title"=>"Pathways of immuno-dysregulation by five new susceptibility genes for SLE.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-10-27 02:31:16"}
  • {"files"=>["https://ndownloader.figshare.com/files/718890"], "description"=>"<p>Each of the seven groups of samples included in this manuscript was independent from each other. In the UK population, direct genotyping was carried out on 905 UK cases<b><sup>a</sup></b> and samples from the British Birth Control Cohort<sup>a</sup> (B58BCC). A total of 905 UK SLE cases were typed and for the analysis, 35 cases were removed following QC. Genotypes from the WTCCC2<b><sup>b</sup></b> were used as out-of-study controls. The published data used for the meta-analysis described in this current manuscript was derived from US and Swedish samples. The US cohort<b><sup>c</sup></b> consisted of samples included in a GWAS and additional non-GWAS'd samples used just for the replication study, as described by Gateva <i>et al</i>. (2009) <a href=\"http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1002341#pgen.1002341-Gateva1\" target=\"_blank\">[4]</a>. Full details of the Swedish (SWE)<b><sup>b</sup></b> replication samples are also described in Gateva <i>et al.</i> (2009) <a href=\"http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1002341#pgen.1002341-Gateva1\" target=\"_blank\">[4]</a>.</p>", "links"=>[], "tags"=>["case-control", "cohorts"], "article_id"=>389250, "categories"=>["Ecology", "Genetics", "Immunology"], "users"=>["Deborah S. Cunninghame Graham", "David L. Morris", "Tushar R. Bhangale", "Lindsey A. Criswell", "Ann-Christine Syvänen", "Lars Rönnblom", "Timothy W. Behrens", "Robert R. Graham", "Timothy J. Vyse"], "doi"=>"https://dx.doi.org/10.1371/journal.pgen.1002341.t001", "stats"=>{"downloads"=>0, "page_views"=>1, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_SLE_Case_Control_Study_Cohorts_used_in_the_study_/389250", "title"=>"SLE Case-Control Study Cohorts used in the study.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2011-10-27 02:34:10"}
  • {"files"=>["https://ndownloader.figshare.com/files/364197", "https://ndownloader.figshare.com/files/364248", "https://ndownloader.figshare.com/files/364675", "https://ndownloader.figshare.com/files/364725", "https://ndownloader.figshare.com/files/364790", "https://ndownloader.figshare.com/files/364846", "https://ndownloader.figshare.com/files/364894", "https://ndownloader.figshare.com/files/364947", "https://ndownloader.figshare.com/files/364997"], "description"=>"<div><p>Systemic lupus erythematosus (SLE) is a complex trait characterised by the production of a range of auto-antibodies and a diverse set of clinical phenotypes. Currently, ∼8% of the genetic contribution to SLE in Europeans is known, following publication of several moderate-sized genome-wide (GW) association studies, which identified loci with a strong effect (OR>1.3). In order to identify additional genes contributing to SLE susceptibility, we conducted a replication study in a UK dataset (870 cases, 5,551 controls) of 23 variants that showed moderate-risk for lupus in previous studies. Association analysis in the UK dataset and subsequent meta-analysis with the published data identified five SLE susceptibility genes reaching genome-wide levels of significance (<em>P<sub>comb</sub></em><5×10<sup>−8</sup>): <em>NCF2</em> (<em>P</em><sub>comb</sub> = 2.87×10<sup>−11</sup>), <em>IKZF1</em> (<em>P</em><sub>comb</sub> = 2.33×10<sup>−9</sup>), <em>IRF8</em> (<em>P</em><sub>comb</sub> = 1.24×10<sup>−8</sup>), <em>IFIH1</em> (<em>P</em><sub>comb</sub> = 1.63×10<sup>−8</sup>), and <em>TYK2</em> (<em>P</em><sub>comb</sub> = 3.88×10<sup>−8</sup>). Each of the five new loci identified here can be mapped into interferon signalling pathways, which are known to play a key role in the pathogenesis of SLE. These results increase the number of established susceptibility genes for lupus to ∼30 and validate the importance of using large datasets to confirm associations of loci which moderately increase the risk for disease.</p> </div>", "links"=>[], "tags"=>["systemic", "lupus", "erythematosus"], "article_id"=>131984, "categories"=>["Ecology", "Genetics", "Immunology"], "users"=>["Deborah S. Cunninghame Graham", "David L. Morris", "Tushar R. Bhangale", "Lindsey A. Criswell", "Ann-Christine Syvänen", "Lars Rönnblom", "Timothy W. Behrens", "Robert R. Graham", "Timothy J. Vyse"], "doi"=>["https://dx.doi.org/10.1371/journal.pgen.1002341.s001", "https://dx.doi.org/10.1371/journal.pgen.1002341.s002", "https://dx.doi.org/10.1371/journal.pgen.1002341.s003", "https://dx.doi.org/10.1371/journal.pgen.1002341.s004", "https://dx.doi.org/10.1371/journal.pgen.1002341.s005", "https://dx.doi.org/10.1371/journal.pgen.1002341.s006", "https://dx.doi.org/10.1371/journal.pgen.1002341.s007", "https://dx.doi.org/10.1371/journal.pgen.1002341.s008", "https://dx.doi.org/10.1371/journal.pgen.1002341.s009"], "stats"=>{"downloads"=>29, "page_views"=>13, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Association_of_NCF2_IKZF1_IRF8_IFIH1_and_TYK2_with_Systemic_Lupus_Erythematosus/131984", "title"=>"Association of <em>NCF2</em>, <em>IKZF1</em>, <em>IRF8</em>, <em>IFIH1</em>, and <em>TYK2</em> with Systemic Lupus Erythematosus", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2011-10-27 00:33:04"}
  • {"files"=>["https://ndownloader.figshare.com/files/718824"], "description"=>"<p>Regression analysis, as described in the <a href=\"http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1002341#s4\" target=\"_blank\">materials and methods</a>, was performed on publically available genotype data from EBV-transformed B cells which were part of the HAPMAP collection and expression data on the same individuals taken from the GEO database. Four populations were used: CEPH, YRI and CHB/JPT (ASN) <a href=\"http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1002341#pgen.1002341-Huffmeier1\" target=\"_blank\">[36]</a>. The GEO dataset was GSE12526 and the expression probes were: A) <i>NCF2</i> (209949_at), B) <i>IRF8</i> (204057_at). For each graph, the mean expression per risk (R) allele and that for the non-risk (r) allele was plotted for each population. The alleles are listed on each bar and for each SNP, the total number of individuals for which there was both genotype and expression data are quoted for the three populations analysed. C) Heritability estimates for each locus were taken from the mRNA by SNP browser (<a href=\"http://www.sph.umich.edu/csg/liang/asthma/\" target=\"_blank\">http://www.sph.umich.edu/csg/liang/asthma/</a>).</p>", "links"=>[], "tags"=>["ebv-transformed", "lymphoblastoid"], "article_id"=>389180, "categories"=>["Ecology", "Genetics", "Immunology"], "users"=>["Deborah S. Cunninghame Graham", "David L. Morris", "Tushar R. Bhangale", "Lindsey A. Criswell", "Ann-Christine Syvänen", "Lars Rönnblom", "Timothy W. Behrens", "Robert R. Graham", "Timothy J. Vyse"], "doi"=>"https://dx.doi.org/10.1371/journal.pgen.1002341.g002", "stats"=>{"downloads"=>1, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Expression_pattern_in_EBV_transformed_lymphoblastoid_cell_lines_/389180", "title"=>"Expression pattern in EBV-transformed lymphoblastoid cell lines.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-10-27 02:33:00"}
  • {"files"=>["https://ndownloader.figshare.com/files/718981"], "description"=>"a<p>For sample numbers see reference <a href=\"http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1002341#pgen.1002341-Gateva1\" target=\"_blank\">[4]</a> and <a href=\"http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1002341#pgen.1002341.s004\" target=\"_blank\">Table S1</a> (US GWAS: 1310 cases and 7859 controls; US replication cohort: 1129 cases and 2991 controls; Swedish replication cohort: 834 cases and 1388 controls).</p>b<p>The risk allele frequency was calculated in control individuals.</p>c<p>Unpublished data.</p>d<p>The combined P value was calculated from imputed genotypes in the US GWAS dataset and direct genotyping in the US and SWE replication datasets.</p>", "links"=>[], "tags"=>["snps", "genome-wide", "sle", "meta-analysis", "swedish"], "article_id"=>389331, "categories"=>["Ecology", "Genetics", "Immunology"], "users"=>["Deborah S. Cunninghame Graham", "David L. Morris", "Tushar R. Bhangale", "Lindsey A. Criswell", "Ann-Christine Syvänen", "Lars Rönnblom", "Timothy W. Behrens", "Robert R. Graham", "Timothy J. Vyse"], "doi"=>"https://dx.doi.org/10.1371/journal.pgen.1002341.t002", "stats"=>{"downloads"=>0, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Novel_SNPs_showing_genome_wide_significance_P_5_10_8722_8_in_SLE_following_meta_analysis_of_UK_US_and_Swedish_cohorts_/389331", "title"=>"Novel SNPs showing genome-wide significance (<i>P</i> = 5×10<sup>−8</sup>) in SLE following meta-analysis of UK, US, and Swedish cohorts.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2011-10-27 02:35:31"}

PMC Usage Stats | Further Information

  • {"month"=>"11", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"2", "full-text"=>"121", "year"=>"2011", "pdf"=>"94", "unique-ip"=>"117", "figure"=>"21", "scanned-summary"=>"0", "supp-data"=>"3"}
  • {"scanned-page-browse"=>"0", "month"=>"12", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"59", "unique-ip"=>"55", "pdf"=>"44", "year"=>"2011", "figure"=>"10", "scanned-summary"=>"0", "supp-data"=>"20"}
  • {"scanned-page-browse"=>"0", "month"=>"1", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"50", "unique-ip"=>"49", "pdf"=>"23", "year"=>"2012", "figure"=>"16", "scanned-summary"=>"0", "supp-data"=>"2"}
  • {"month"=>"2", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"67", "year"=>"2012", "pdf"=>"40", "unique-ip"=>"59", "figure"=>"19", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"3", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"74", "unique-ip"=>"69", "pdf"=>"47", "year"=>"2012", "figure"=>"17", "scanned-summary"=>"0", "supp-data"=>"11"}
  • {"month"=>"4", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"2", "full-text"=>"48", "year"=>"2012", "pdf"=>"26", "unique-ip"=>"49", "figure"=>"18", "scanned-summary"=>"0", "supp-data"=>"1"}
  • {"scanned-page-browse"=>"0", "month"=>"5", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"33", "unique-ip"=>"38", "pdf"=>"13", "year"=>"2012", "figure"=>"6", "scanned-summary"=>"0", "supp-data"=>"4"}
  • {"month"=>"6", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"48", "year"=>"2012", "pdf"=>"33", "unique-ip"=>"44", "figure"=>"6", "scanned-summary"=>"0", "supp-data"=>"5"}
  • {"unique-ip"=>"47", "full-text"=>"40", "pdf"=>"31", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"10", "supp-data"=>"7", "cited-by"=>"0", "year"=>"2012", "month"=>"7"}
  • {"unique-ip"=>"31", "full-text"=>"35", "pdf"=>"19", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"8"}
  • {"unique-ip"=>"29", "full-text"=>"26", "pdf"=>"14", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"9"}
  • {"unique-ip"=>"26", "full-text"=>"24", "pdf"=>"17", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"10"}
  • {"unique-ip"=>"26", "full-text"=>"19", "pdf"=>"13", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"7", "cited-by"=>"0", "year"=>"2012", "month"=>"12"}
  • {"unique-ip"=>"39", "full-text"=>"47", "pdf"=>"14", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2013", "month"=>"1"}
  • {"unique-ip"=>"17", "full-text"=>"16", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"2"}
  • {"unique-ip"=>"22", "full-text"=>"22", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"9", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"3"}
  • {"unique-ip"=>"30", "full-text"=>"27", "pdf"=>"10", "abstract"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"1", "cited-by"=>"1", "year"=>"2013", "month"=>"4"}
  • {"unique-ip"=>"23", "full-text"=>"22", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"17", "cited-by"=>"0", "year"=>"2012", "month"=>"11"}
  • {"unique-ip"=>"29", "full-text"=>"26", "pdf"=>"5", "abstract"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"14", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2013", "month"=>"5"}
  • {"unique-ip"=>"21", "full-text"=>"16", "pdf"=>"13", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"6"}
  • {"unique-ip"=>"11", "full-text"=>"11", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"7"}
  • {"unique-ip"=>"17", "full-text"=>"17", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"8", "cited-by"=>"0", "year"=>"2013", "month"=>"8"}
  • {"unique-ip"=>"16", "full-text"=>"14", "pdf"=>"10", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"8", "cited-by"=>"0", "year"=>"2013", "month"=>"9"}
  • {"unique-ip"=>"16", "full-text"=>"18", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"10"}
  • {"unique-ip"=>"19", "full-text"=>"24", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"8", "cited-by"=>"0", "year"=>"2013", "month"=>"11"}
  • {"unique-ip"=>"16", "full-text"=>"18", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"12"}
  • {"unique-ip"=>"13", "full-text"=>"11", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"1"}
  • {"unique-ip"=>"19", "full-text"=>"26", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2014", "month"=>"2"}
  • {"unique-ip"=>"25", "full-text"=>"34", "pdf"=>"13", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"13", "cited-by"=>"0", "year"=>"2014", "month"=>"3"}
  • {"unique-ip"=>"24", "full-text"=>"26", "pdf"=>"13", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"5"}
  • {"unique-ip"=>"17", "full-text"=>"18", "pdf"=>"12", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"6"}
  • {"unique-ip"=>"14", "full-text"=>"17", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"5", "cited-by"=>"0", "year"=>"2014", "month"=>"4"}
  • {"unique-ip"=>"21", "full-text"=>"18", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2014", "month"=>"7"}
  • {"unique-ip"=>"17", "full-text"=>"12", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2014", "month"=>"8"}
  • {"unique-ip"=>"40", "full-text"=>"32", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"10", "cited-by"=>"0", "year"=>"2014", "month"=>"9"}
  • {"unique-ip"=>"26", "full-text"=>"19", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"10"}
  • {"unique-ip"=>"26", "full-text"=>"23", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"4", "cited-by"=>"0", "year"=>"2014", "month"=>"11"}
  • {"unique-ip"=>"16", "full-text"=>"16", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"12"}
  • {"unique-ip"=>"18", "full-text"=>"12", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"1", "cited-by"=>"1", "year"=>"2015", "month"=>"1"}
  • {"unique-ip"=>"12", "full-text"=>"11", "pdf"=>"10", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2015", "month"=>"2"}
  • {"unique-ip"=>"18", "full-text"=>"16", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"2", "year"=>"2015", "month"=>"3"}
  • {"unique-ip"=>"15", "full-text"=>"13", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"4"}
  • {"unique-ip"=>"24", "full-text"=>"27", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"5"}
  • {"unique-ip"=>"16", "full-text"=>"17", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"6"}
  • {"unique-ip"=>"12", "full-text"=>"12", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"7"}
  • {"unique-ip"=>"15", "full-text"=>"10", "pdf"=>"10", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"8"}
  • {"unique-ip"=>"19", "full-text"=>"21", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"9"}
  • {"unique-ip"=>"28", "full-text"=>"26", "pdf"=>"15", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"8", "cited-by"=>"0", "year"=>"2015", "month"=>"10"}
  • {"unique-ip"=>"25", "full-text"=>"22", "pdf"=>"11", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"11", "cited-by"=>"3", "year"=>"2015", "month"=>"11"}
  • {"unique-ip"=>"22", "full-text"=>"16", "pdf"=>"12", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2015", "month"=>"12"}
  • {"unique-ip"=>"20", "full-text"=>"20", "pdf"=>"12", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"1"}
  • {"unique-ip"=>"23", "full-text"=>"29", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"2"}
  • {"unique-ip"=>"15", "full-text"=>"16", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"11", "cited-by"=>"1", "year"=>"2016", "month"=>"3"}
  • {"unique-ip"=>"12", "full-text"=>"11", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"4"}
  • {"unique-ip"=>"11", "full-text"=>"10", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2016", "month"=>"5"}
  • {"unique-ip"=>"14", "full-text"=>"12", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2016", "month"=>"6"}
  • {"unique-ip"=>"14", "full-text"=>"18", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"19", "cited-by"=>"0", "year"=>"2016", "month"=>"7"}
  • {"unique-ip"=>"12", "full-text"=>"13", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"8"}
  • {"unique-ip"=>"14", "full-text"=>"15", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2016", "month"=>"9"}
  • {"unique-ip"=>"10", "full-text"=>"11", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"10"}
  • {"unique-ip"=>"13", "full-text"=>"13", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"11"}
  • {"unique-ip"=>"6", "full-text"=>"7", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"12"}
  • {"unique-ip"=>"12", "full-text"=>"12", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"1"}
  • {"unique-ip"=>"9", "full-text"=>"9", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"1", "cited-by"=>"2", "year"=>"2017", "month"=>"2"}
  • {"unique-ip"=>"16", "full-text"=>"17", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"3"}
  • {"unique-ip"=>"10", "full-text"=>"10", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"4"}
  • {"unique-ip"=>"11", "full-text"=>"12", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2017", "month"=>"5"}
  • {"unique-ip"=>"8", "full-text"=>"8", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"6"}
  • {"unique-ip"=>"13", "full-text"=>"12", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"7"}
  • {"unique-ip"=>"10", "full-text"=>"9", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"4", "cited-by"=>"0", "year"=>"2017", "month"=>"8"}
  • {"unique-ip"=>"12", "full-text"=>"14", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"9"}
  • {"unique-ip"=>"10", "full-text"=>"11", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"10"}
  • {"unique-ip"=>"14", "full-text"=>"16", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"11"}
  • {"unique-ip"=>"13", "full-text"=>"9", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2017", "month"=>"12"}
  • {"unique-ip"=>"13", "full-text"=>"14", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"1"}
  • {"unique-ip"=>"15", "full-text"=>"13", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"3"}
  • {"unique-ip"=>"18", "full-text"=>"15", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2019", "month"=>"1"}
  • {"unique-ip"=>"5", "full-text"=>"5", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"5"}
  • {"unique-ip"=>"10", "full-text"=>"11", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"4"}
  • {"unique-ip"=>"9", "full-text"=>"8", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"6"}
  • {"unique-ip"=>"13", "full-text"=>"10", "pdf"=>"9", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"11", "cited-by"=>"0", "year"=>"2018", "month"=>"7"}
  • {"unique-ip"=>"7", "full-text"=>"7", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2018", "month"=>"8"}
  • {"unique-ip"=>"6", "full-text"=>"5", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"9"}
  • {"unique-ip"=>"17", "full-text"=>"15", "pdf"=>"6", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2018", "month"=>"10"}
  • {"unique-ip"=>"15", "full-text"=>"17", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"12"}
  • {"unique-ip"=>"10", "full-text"=>"10", "pdf"=>"6", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"7", "cited-by"=>"0", "year"=>"2018", "month"=>"11"}
  • {"unique-ip"=>"15", "full-text"=>"16", "pdf"=>"9", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2019", "month"=>"2"}
  • {"unique-ip"=>"14", "full-text"=>"18", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2019", "month"=>"3"}
  • {"unique-ip"=>"30", "full-text"=>"36", "pdf"=>"12", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"9", "cited-by"=>"0", "year"=>"2019", "month"=>"4"}
  • {"unique-ip"=>"31", "full-text"=>"26", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2019", "month"=>"5"}
  • {"unique-ip"=>"15", "full-text"=>"14", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"8"}
  • {"unique-ip"=>"12", "full-text"=>"9", "pdf"=>"6", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"9"}
  • {"unique-ip"=>"20", "full-text"=>"17", "pdf"=>"6", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"10"}
  • {"unique-ip"=>"18", "full-text"=>"20", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"12"}
  • {"unique-ip"=>"24", "full-text"=>"26", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"2"}
  • {"unique-ip"=>"23", "full-text"=>"23", "pdf"=>"7", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"3"}
  • {"unique-ip"=>"19", "full-text"=>"14", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"4"}
  • {"unique-ip"=>"23", "full-text"=>"26", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2020", "month"=>"5"}
  • {"unique-ip"=>"9", "full-text"=>"8", "pdf"=>"6", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"6"}
  • {"unique-ip"=>"17", "full-text"=>"40", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"10", "cited-by"=>"2", "year"=>"2020", "month"=>"7"}
  • {"unique-ip"=>"12", "full-text"=>"17", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"9", "cited-by"=>"0", "year"=>"2020", "month"=>"8"}
  • {"unique-ip"=>"13", "full-text"=>"23", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2020", "month"=>"9"}

Relative Metric

{"start_date"=>"2011-01-01T00:00:00Z", "end_date"=>"2011-12-31T00:00:00Z", "subject_areas"=>[{"subject_area"=>"/Biology and life sciences/Biochemistry", "average_usage"=>[290, 559, 698, 813, 927, 1028, 1121, 1206, 1289, 1360, 1433, 1501, 1569, 1637, 1707, 1774, 1841, 1911, 1974, 2038, 2103, 2161, 2219, 2280, 2345, 2406, 2466, 2529, 2592, 2654, 2713, 2772, 2835, 2893, 2954, 3020, 3071]}, {"subject_area"=>"/Biology and life sciences/Computational biology", "average_usage"=>[348, 636, 778, 900, 1011, 1120, 1220, 1303, 1392, 1471, 1554, 1628, 1704, 1776, 1855, 1934, 2016, 2084, 2149, 2232, 2303, 2379, 2465, 2539, 2593, 2657, 2722, 2786, 2856, 2918, 2989, 3057, 3124, 3185, 3234, 3300, 3343]}, {"subject_area"=>"/Biology and life sciences/Genetics", "average_usage"=>[308, 576, 718, 839, 960, 1061, 1156, 1249, 1331, 1408, 1484, 1558, 1625, 1698, 1767, 1842, 1912, 1990, 2058, 2128, 2183, 2259, 2317, 2378, 2436, 2488, 2552, 2627, 2692, 2759, 2820, 2881, 2940, 3001, 3061, 3117, 3164]}, {"subject_area"=>"/Biology and life sciences/Immunology", "average_usage"=>[303, 577, 713, 831, 950, 1048, 1144, 1230, 1307, 1381, 1454, 1521, 1590, 1655, 1713, 1778, 1848, 1913, 1972, 2033, 2098, 2154, 2215, 2263, 2322, 2388, 2436, 2500, 2571, 2623, 2689, 2754, 2806, 2864, 2930, 2984, 3038]}, {"subject_area"=>"/Medicine and health sciences", "average_usage"=>[303, 571, 709, 823, 937, 1038, 1133, 1216, 1298, 1370, 1447, 1518, 1588, 1656, 1725, 1790, 1856, 1926, 1992, 2054, 2118, 2182, 2242, 2301, 2363, 2425, 2484, 2544, 2602, 2662, 2716, 2776, 2841, 2901, 2960, 3016, 3071]}, {"subject_area"=>"/Medicine and health sciences/Clinical medicine", "average_usage"=>[286, 588, 710, 818, 936, 1045, 1150, 1241, 1308, 1382, 1463, 1545, 1602, 1662, 1728, 1807, 1865, 1931, 1998, 2074, 2123, 2191, 2236, 2276, 2342, 2405, 2482, 2536, 2586, 2655, 2710, 2778, 2816, 2895, 2947, 2997, 3047]}, {"subject_area"=>"/Medicine and health sciences/Immunology", "average_usage"=>[299, 582, 725, 844, 971, 1076, 1167, 1253, 1328, 1403, 1480, 1551, 1620, 1691, 1756, 1821, 1893, 1962, 2032, 2110, 2178, 2236, 2300, 2358, 2419, 2465, 2529, 2587, 2643, 2700, 2756, 2817, 2869, 2932, 2986, 3046, 3101]}, {"subject_area"=>"/People and places/Population groupings", "average_usage"=>[344, 630, 756, 876, 981, 1083, 1179, 1272, 1346, 1421, 1508, 1583, 1659, 1744, 1809, 1891, 1954, 2030, 2105, 2174, 2247, 2324, 2386, 2441, 2502, 2557, 2621, 2685, 2753, 2825, 2882, 2935, 2989, 3052, 3117, 3181, 3242]}, {"subject_area"=>"/Physical sciences", "average_usage"=>[303, 547, 667, 770, 875, 974, 1062, 1140, 1210, 1276, 1344, 1408, 1473, 1534, 1602, 1665, 1732, 1800, 1863, 1920, 1984, 2048, 2099, 2161, 2222, 2285, 2341, 2404, 2473, 2528, 2595, 2650, 2713, 2772, 2835, 2886, 2938]}, {"subject_area"=>"/Physical sciences/Mathematics", "average_usage"=>[347, 582, 700, 805, 909, 997, 1061, 1147, 1220, 1282, 1350, 1411, 1471, 1532, 1600, 1665, 1726, 1790, 1868, 1927, 1986, 2048, 2105, 2166, 2229, 2288, 2347, 2407, 2463, 2525, 2589, 2650, 2704, 2755, 2806, 2854, 2896]}]}
Loading … Spinner
There are currently no alerts