Integrating Genome-Wide Genetic Variations and Monocyte Expression Data Reveals Trans-Regulated Gene Modules in Humans
Events
Loading … Spinner

CiteULike | Further Information

Mendeley | Further Information

{"title"=>"Integrating Genome-Wide genetic variations and monocyte expression data reveals Trans-Regulated gene modules in humans", "type"=>"journal", "authors"=>[{"first_name"=>"Maxime", "last_name"=>"Rotival", "scopus_author_id"=>"24336000200"}, {"first_name"=>"Tanja", "last_name"=>"Zeller", "scopus_author_id"=>"8840941700"}, {"first_name"=>"Philipp S.", "last_name"=>"Wild", "scopus_author_id"=>"35075353400"}, {"first_name"=>"Seraya", "last_name"=>"Maouche", "scopus_author_id"=>"24470740500"}, {"first_name"=>"Silke", "last_name"=>"Szymczak", "scopus_author_id"=>"35300939900"}, {"first_name"=>"Arne", "last_name"=>"Schillert", "scopus_author_id"=>"24729569300"}, {"first_name"=>"Raphaele", "last_name"=>"Castagné", "scopus_author_id"=>"36458077800"}, {"first_name"=>"Arne", "last_name"=>"Deiseroth", "scopus_author_id"=>"50261375400"}, {"first_name"=>"Carole", "last_name"=>"Proust", "scopus_author_id"=>"24462243900"}, {"first_name"=>"Jessy", "last_name"=>"Brocheton", "scopus_author_id"=>"35728053700"}, {"first_name"=>"Tiphaine", "last_name"=>"Godefroy", "scopus_author_id"=>"8708613200"}, {"first_name"=>"Claire", "last_name"=>"Perret", "scopus_author_id"=>"8708614600"}, {"first_name"=>"Marine", "last_name"=>"Germain", "scopus_author_id"=>"35728782400"}, {"first_name"=>"Medea", "last_name"=>"Eleftheriadis", "scopus_author_id"=>"35069133900"}, {"first_name"=>"Christoph R.", "last_name"=>"Sinning", "scopus_author_id"=>"23993115500"}, {"first_name"=>"Renate B.", "last_name"=>"Schnabel", "scopus_author_id"=>"8708614100"}, {"first_name"=>"Edith", "last_name"=>"Lubos", "scopus_author_id"=>"8365789700"}, {"first_name"=>"Karl J.", "last_name"=>"Lackner", "scopus_author_id"=>"7102744849"}, {"first_name"=>"Heidi", "last_name"=>"Rossmann", "scopus_author_id"=>"7004039151"}, {"first_name"=>"Thomas", "last_name"=>"Münzel", "scopus_author_id"=>"7005738983"}, {"first_name"=>"Augusto", "last_name"=>"Rendon", "scopus_author_id"=>"26536636300"}, {"first_name"=>"Cardiogenics", "last_name"=>"Consortium", "scopus_author_id"=>"54881297500"}, {"first_name"=>"Jeanette", "last_name"=>"Erdmann", "scopus_author_id"=>"57190212945"}, {"first_name"=>"Panos", "last_name"=>"Deloukas", "scopus_author_id"=>"7003287098"}, {"first_name"=>"Christian", "last_name"=>"Hengstenberg", "scopus_author_id"=>"7003528759"}, {"first_name"=>"Patrick", "last_name"=>"Diemert", "scopus_author_id"=>"36999848800"}, {"first_name"=>"Gilles", "last_name"=>"Montalescot", "scopus_author_id"=>"7102302494"}, {"first_name"=>"Willem H.", "last_name"=>"Ouwehand", "scopus_author_id"=>"55801267700"}, {"first_name"=>"Nilesh J.", "last_name"=>"Samani", "scopus_author_id"=>"7004345054"}, {"first_name"=>"Heribert", "last_name"=>"Schunkert", "scopus_author_id"=>"7006507139"}, {"first_name"=>"David Alexandre", "last_name"=>"Tregouet", "scopus_author_id"=>"6701660940"}, {"first_name"=>"Andreas", "last_name"=>"Ziegler", "scopus_author_id"=>"7201554928"}, {"first_name"=>"Alison H.", "last_name"=>"Goodall", "scopus_author_id"=>"7005360646"}, {"first_name"=>"François", "last_name"=>"Cambien", "scopus_author_id"=>"7101622418"}, {"first_name"=>"Laurence", "last_name"=>"Tiret", "scopus_author_id"=>"7006257206"}, {"first_name"=>"Stefan", "last_name"=>"Blankenberg", "scopus_author_id"=>"7004496618"}], "year"=>2011, "source"=>"PLoS Genetics", "identifiers"=>{"issn"=>"15537390", "scopus"=>"2-s2.0-84855267424", "pui"=>"364024486", "doi"=>"10.1371/journal.pgen.1002367", "isbn"=>"1553-7404 (Electronic)\\r1553-7390 (Linking)", "sgr"=>"84855267424", "pmid"=>"22144904"}, "id"=>"5d146c5b-869d-369e-9260-006d9124e847", "abstract"=>"One major expectation from the transcriptome in humans is to characterize the biological basis of associations identified by genome-wide association studies. So far, few cis expression quantitative trait loci (eQTLs) have been reliably related to disease susceptibility. Trans-regulating mechanisms may play a more prominent role in disease susceptibility. We analyzed 12,808 genes detected in at least 5% of circulating monocyte samples from a population-based sample of 1,490 European unrelated subjects. We applied a method of extraction of expression patterns-independent component analysis-to identify sets of co-regulated genes. These patterns were then related to 675,350 SNPs to identify major trans-acting regulators. We detected three genomic regions significantly associated with co-regulated gene modules. Association of these loci with multiple expression traits was replicated in Cardiogenics, an independent study in which expression profiles of monocytes were available in 758 subjects. The locus 12q13 (lead SNP rs11171739), previously identified as a type 1 diabetes locus, was associated with a pattern including two cis eQTLs, RPS26 and SUOX, and 5 trans eQTLs, one of which (MADCAM1) is a potential candidate for mediating T1D susceptibility. The locus 12q24 (lead SNP rs653178), which has demonstrated extensive disease pleiotropy, including type 1 diabetes, hypertension, and celiac disease, was associated to a pattern strongly correlating to blood pressure level. The strongest trans eQTL in this pattern was CRIP1, a known marker of cellular proliferation in cancer. The locus 12q15 (lead SNP rs11177644) was associated with a pattern driven by two cis eQTLs, LYZ and YEATS4, and including 34 trans eQTLs, several of them tumor-related genes. This study shows that a method exploiting the structure of co-expressions among genes can help identify genomic regions involved in trans regulation of sets of genes and can provide clues for understanding the mechanisms linking genome-wide association loci to disease.", "link"=>"http://www.mendeley.com/research/integrating-genomewide-genetic-variations-monocyte-expression-data-reveals-transregulated-gene-modul", "reader_count"=>139, "reader_count_by_academic_status"=>{"Unspecified"=>3, "Professor > Associate Professor"=>13, "Researcher"=>40, "Student > Doctoral Student"=>3, "Student > Ph. D. Student"=>46, "Student > Postgraduate"=>3, "Student > Master"=>10, "Other"=>3, "Student > Bachelor"=>7, "Professor"=>11}, "reader_count_by_user_role"=>{"Unspecified"=>3, "Professor > Associate Professor"=>13, "Researcher"=>40, "Student > Doctoral Student"=>3, "Student > Ph. D. Student"=>46, "Student > Postgraduate"=>3, "Student > Master"=>10, "Other"=>3, "Student > Bachelor"=>7, "Professor"=>11}, "reader_count_by_subject_area"=>{"Unspecified"=>6, "Biochemistry, Genetics and Molecular Biology"=>13, "Mathematics"=>3, "Medicine and Dentistry"=>20, "Agricultural and Biological Sciences"=>87, "Arts and Humanities"=>1, "Business, Management and Accounting"=>1, "Computer Science"=>5, "Immunology and Microbiology"=>1, "Engineering"=>2}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>2}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>20}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>87}, "Computer Science"=>{"Computer Science"=>5}, "Business, Management and Accounting"=>{"Business, Management and Accounting"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>13}, "Mathematics"=>{"Mathematics"=>3}, "Unspecified"=>{"Unspecified"=>6}, "Arts and Humanities"=>{"Arts and Humanities"=>1}}, "reader_count_by_country"=>{"New Zealand"=>1, "Austria"=>1, "Belgium"=>1, "United States"=>9, "Ireland"=>2, "China"=>1, "Italy"=>1, "United Kingdom"=>1, "France"=>1}, "group_count"=>14}

CrossRef

Scopus | Further Information

{"@_fa"=>"true", "link"=>[{"@_fa"=>"true", "@ref"=>"self", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/84855267424"}, {"@_fa"=>"true", "@ref"=>"author-affiliation", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/84855267424?field=author,affiliation"}, {"@_fa"=>"true", "@ref"=>"scopus", "@href"=>"https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84855267424&origin=inward"}, {"@_fa"=>"true", "@ref"=>"scopus-citedby", "@href"=>"https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=84855267424&origin=inward"}], "prism:url"=>"https://api.elsevier.com/content/abstract/scopus_id/84855267424", "dc:identifier"=>"SCOPUS_ID:84855267424", "eid"=>"2-s2.0-84855267424", "dc:title"=>"Integrating Genome-Wide genetic variations and monocyte expression data reveals Trans-Regulated gene modules in humans", "dc:creator"=>"Rotival M.", "prism:publicationName"=>"PLoS Genetics", "prism:issn"=>"15537390", "prism:eIssn"=>"15537404", "prism:volume"=>"7", "prism:issueIdentifier"=>"12", "prism:pageRange"=>nil, "prism:coverDate"=>"2011-12-01", "prism:coverDisplayDate"=>"December 2011", "prism:doi"=>"10.1371/journal.pgen.1002367", "citedby-count"=>"78", "affiliation"=>[{"@_fa"=>"true", "affilname"=>"Inserm", "affiliation-city"=>"Paris", "affiliation-country"=>"France"}], "pubmed-id"=>"22144904", "prism:aggregationType"=>"Journal", "subtype"=>"ar", "subtypeDescription"=>"Article", "article-number"=>"e1002367", "source-id"=>"4000151808", "openaccess"=>"1", "openaccessFlag"=>true}

Facebook

  • {"url"=>"http%3A%2F%2Fjournals.plos.org%2Fplosgenetics%2Farticle%3Fid%3D10.1371%252Fjournal.pgen.1002367", "share_count"=>0, "like_count"=>0, "comment_count"=>0, "click_count"=>0, "total_count"=>0}

Counter

  • {"month"=>"12", "year"=>"2011", "pdf_views"=>"288", "xml_views"=>"17", "html_views"=>"1166"}
  • {"month"=>"1", "year"=>"2012", "pdf_views"=>"181", "xml_views"=>"63", "html_views"=>"751"}
  • {"month"=>"2", "year"=>"2012", "pdf_views"=>"55", "xml_views"=>"0", "html_views"=>"172"}
  • {"month"=>"3", "year"=>"2012", "pdf_views"=>"63", "xml_views"=>"0", "html_views"=>"173"}
  • {"month"=>"4", "year"=>"2012", "pdf_views"=>"40", "xml_views"=>"2", "html_views"=>"165"}
  • {"month"=>"5", "year"=>"2012", "pdf_views"=>"52", "xml_views"=>"1", "html_views"=>"210"}
  • {"month"=>"6", "year"=>"2012", "pdf_views"=>"30", "xml_views"=>"3", "html_views"=>"145"}
  • {"month"=>"7", "year"=>"2012", "pdf_views"=>"15", "xml_views"=>"1", "html_views"=>"94"}
  • {"month"=>"8", "year"=>"2012", "pdf_views"=>"22", "xml_views"=>"5", "html_views"=>"90"}
  • {"month"=>"9", "year"=>"2012", "pdf_views"=>"24", "xml_views"=>"1", "html_views"=>"84"}
  • {"month"=>"10", "year"=>"2012", "pdf_views"=>"34", "xml_views"=>"2", "html_views"=>"101"}
  • {"month"=>"11", "year"=>"2012", "pdf_views"=>"29", "xml_views"=>"0", "html_views"=>"109"}
  • {"month"=>"12", "year"=>"2012", "pdf_views"=>"23", "xml_views"=>"0", "html_views"=>"103"}
  • {"month"=>"1", "year"=>"2013", "pdf_views"=>"28", "xml_views"=>"0", "html_views"=>"125"}
  • {"month"=>"2", "year"=>"2013", "pdf_views"=>"14", "xml_views"=>"2", "html_views"=>"234"}
  • {"month"=>"3", "year"=>"2013", "pdf_views"=>"18", "xml_views"=>"0", "html_views"=>"103"}
  • {"month"=>"4", "year"=>"2013", "pdf_views"=>"23", "xml_views"=>"0", "html_views"=>"111"}
  • {"month"=>"5", "year"=>"2013", "pdf_views"=>"17", "xml_views"=>"1", "html_views"=>"109"}
  • {"month"=>"6", "year"=>"2013", "pdf_views"=>"22", "xml_views"=>"0", "html_views"=>"104"}
  • {"month"=>"7", "year"=>"2013", "pdf_views"=>"19", "xml_views"=>"0", "html_views"=>"102"}
  • {"month"=>"8", "year"=>"2013", "pdf_views"=>"14", "xml_views"=>"0", "html_views"=>"81"}
  • {"month"=>"9", "year"=>"2013", "pdf_views"=>"16", "xml_views"=>"0", "html_views"=>"376"}
  • {"month"=>"10", "year"=>"2013", "pdf_views"=>"14", "xml_views"=>"1", "html_views"=>"409"}
  • {"month"=>"11", "year"=>"2013", "pdf_views"=>"10", "xml_views"=>"1", "html_views"=>"98"}
  • {"month"=>"12", "year"=>"2013", "pdf_views"=>"20", "xml_views"=>"2", "html_views"=>"143"}
  • {"month"=>"1", "year"=>"2014", "pdf_views"=>"14", "xml_views"=>"0", "html_views"=>"109"}
  • {"month"=>"2", "year"=>"2014", "pdf_views"=>"10", "xml_views"=>"1", "html_views"=>"99"}
  • {"month"=>"3", "year"=>"2014", "pdf_views"=>"11", "xml_views"=>"2", "html_views"=>"140"}
  • {"month"=>"4", "year"=>"2014", "pdf_views"=>"8", "xml_views"=>"1", "html_views"=>"140"}
  • {"month"=>"5", "year"=>"2014", "pdf_views"=>"30", "xml_views"=>"0", "html_views"=>"192"}
  • {"month"=>"6", "year"=>"2014", "pdf_views"=>"18", "xml_views"=>"0", "html_views"=>"122"}
  • {"month"=>"7", "year"=>"2014", "pdf_views"=>"25", "xml_views"=>"1", "html_views"=>"147"}
  • {"month"=>"8", "year"=>"2014", "pdf_views"=>"8", "xml_views"=>"2", "html_views"=>"98"}
  • {"month"=>"9", "year"=>"2014", "pdf_views"=>"16", "xml_views"=>"0", "html_views"=>"123"}
  • {"month"=>"10", "year"=>"2014", "pdf_views"=>"10", "xml_views"=>"2", "html_views"=>"158"}
  • {"month"=>"11", "year"=>"2014", "pdf_views"=>"9", "xml_views"=>"2", "html_views"=>"175"}
  • {"month"=>"12", "year"=>"2014", "pdf_views"=>"9", "xml_views"=>"1", "html_views"=>"227"}
  • {"month"=>"1", "year"=>"2015", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"315"}
  • {"month"=>"2", "year"=>"2015", "pdf_views"=>"8", "xml_views"=>"1", "html_views"=>"67"}
  • {"month"=>"3", "year"=>"2015", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"83"}
  • {"month"=>"4", "year"=>"2015", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"83"}
  • {"month"=>"5", "year"=>"2015", "pdf_views"=>"10", "xml_views"=>"1", "html_views"=>"119"}
  • {"month"=>"6", "year"=>"2015", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"85"}
  • {"month"=>"7", "year"=>"2015", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"44"}
  • {"month"=>"8", "year"=>"2015", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"78"}
  • {"month"=>"9", "year"=>"2015", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"59"}
  • {"month"=>"10", "year"=>"2015", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"66"}
  • {"month"=>"11", "year"=>"2015", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"59"}
  • {"month"=>"12", "year"=>"2015", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"48"}
  • {"month"=>"1", "year"=>"2016", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"33"}
  • {"month"=>"2", "year"=>"2016", "pdf_views"=>"29", "xml_views"=>"0", "html_views"=>"38"}
  • {"month"=>"3", "year"=>"2016", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"51"}
  • {"month"=>"4", "year"=>"2016", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"42"}
  • {"month"=>"5", "year"=>"2016", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"49"}
  • {"month"=>"6", "year"=>"2016", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"34"}
  • {"month"=>"7", "year"=>"2016", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"40"}
  • {"month"=>"8", "year"=>"2016", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"69"}
  • {"month"=>"9", "year"=>"2016", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"59"}
  • {"month"=>"10", "year"=>"2016", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"24"}
  • {"month"=>"11", "year"=>"2016", "pdf_views"=>"6", "xml_views"=>"2", "html_views"=>"28"}
  • {"month"=>"12", "year"=>"2016", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"34"}
  • {"month"=>"1", "year"=>"2017", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"54"}
  • {"month"=>"2", "year"=>"2017", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"58"}
  • {"month"=>"3", "year"=>"2017", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"57"}
  • {"month"=>"4", "year"=>"2017", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"46"}
  • {"month"=>"5", "year"=>"2017", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"48"}
  • {"month"=>"6", "year"=>"2017", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"43"}
  • {"month"=>"7", "year"=>"2017", "pdf_views"=>"10", "xml_views"=>"1", "html_views"=>"35"}
  • {"month"=>"8", "year"=>"2017", "pdf_views"=>"7", "xml_views"=>"1", "html_views"=>"24"}
  • {"month"=>"9", "year"=>"2017", "pdf_views"=>"9", "xml_views"=>"1", "html_views"=>"41"}
  • {"month"=>"10", "year"=>"2017", "pdf_views"=>"7", "xml_views"=>"2", "html_views"=>"56"}
  • {"month"=>"11", "year"=>"2017", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"48"}
  • {"month"=>"12", "year"=>"2017", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"43"}
  • {"month"=>"1", "year"=>"2018", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"24"}
  • {"month"=>"2", "year"=>"2018", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"21"}
  • {"month"=>"3", "year"=>"2018", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"26"}
  • {"month"=>"4", "year"=>"2018", "pdf_views"=>"14", "xml_views"=>"2", "html_views"=>"23"}
  • {"month"=>"5", "year"=>"2018", "pdf_views"=>"23", "xml_views"=>"1", "html_views"=>"43"}
  • {"month"=>"6", "year"=>"2018", "pdf_views"=>"26", "xml_views"=>"0", "html_views"=>"52"}
  • {"month"=>"7", "year"=>"2018", "pdf_views"=>"11", "xml_views"=>"4", "html_views"=>"38"}
  • {"month"=>"8", "year"=>"2018", "pdf_views"=>"27", "xml_views"=>"3", "html_views"=>"42"}
  • {"month"=>"9", "year"=>"2018", "pdf_views"=>"22", "xml_views"=>"0", "html_views"=>"29"}
  • {"month"=>"10", "year"=>"2018", "pdf_views"=>"6", "xml_views"=>"1", "html_views"=>"15"}
  • {"month"=>"11", "year"=>"2018", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"26"}
  • {"month"=>"12", "year"=>"2018", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"6"}
  • {"month"=>"1", "year"=>"2019", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"21"}
  • {"month"=>"2", "year"=>"2019", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"14"}
  • {"month"=>"3", "year"=>"2019", "pdf_views"=>"12", "xml_views"=>"2", "html_views"=>"24"}
  • {"month"=>"4", "year"=>"2019", "pdf_views"=>"26", "xml_views"=>"0", "html_views"=>"31"}
  • {"month"=>"5", "year"=>"2019", "pdf_views"=>"26", "xml_views"=>"0", "html_views"=>"25"}
  • {"month"=>"6", "year"=>"2019", "pdf_views"=>"21", "xml_views"=>"0", "html_views"=>"50"}
  • {"month"=>"7", "year"=>"2019", "pdf_views"=>"29", "xml_views"=>"0", "html_views"=>"52"}
  • {"month"=>"8", "year"=>"2019", "pdf_views"=>"29", "xml_views"=>"0", "html_views"=>"41"}
  • {"month"=>"9", "year"=>"2019", "pdf_views"=>"16", "xml_views"=>"0", "html_views"=>"42"}
  • {"month"=>"10", "year"=>"2019", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"28"}
  • {"month"=>"11", "year"=>"2019", "pdf_views"=>"24", "xml_views"=>"0", "html_views"=>"22"}
  • {"month"=>"12", "year"=>"2019", "pdf_views"=>"17", "xml_views"=>"0", "html_views"=>"28"}
  • {"month"=>"1", "year"=>"2020", "pdf_views"=>"13", "xml_views"=>"1", "html_views"=>"16"}
  • {"month"=>"2", "year"=>"2020", "pdf_views"=>"17", "xml_views"=>"1", "html_views"=>"27"}
  • {"month"=>"3", "year"=>"2020", "pdf_views"=>"20", "xml_views"=>"0", "html_views"=>"30"}
  • {"month"=>"4", "year"=>"2020", "pdf_views"=>"37", "xml_views"=>"0", "html_views"=>"19"}
  • {"month"=>"5", "year"=>"2020", "pdf_views"=>"59", "xml_views"=>"0", "html_views"=>"30"}
  • {"month"=>"6", "year"=>"2020", "pdf_views"=>"26", "xml_views"=>"0", "html_views"=>"21"}
  • {"month"=>"7", "year"=>"2020", "pdf_views"=>"14", "xml_views"=>"0", "html_views"=>"31"}
  • {"month"=>"8", "year"=>"2020", "pdf_views"=>"26", "xml_views"=>"0", "html_views"=>"36"}
  • {"month"=>"9", "year"=>"2020", "pdf_views"=>"25", "xml_views"=>"1", "html_views"=>"32"}
  • {"month"=>"10", "year"=>"2020", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"24"}

Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/707489"], "description"=>"<p>Box plots showing the association of rs653178 at locus 12q24 (<i>SH2B3</i>) with <i>CRIP1</i> expression in GHS and Cardiogenics.</p>", "links"=>[], "tags"=>["plots", "rs653178", "locus", "12q24", "ghs"], "article_id"=>377790, "categories"=>["Genetics"], "users"=>["Maxime Rotival", "Tanja Zeller", "Philipp S. Wild", "Seraya Maouche", "Silke Szymczak", "Arne Schillert", "Raphaele Castagné", "Arne Deiseroth", "Carole Proust", "Jessy Brocheton", "Tiphaine Godefroy", "Claire Perret", "Marine Germain", "Medea Eleftheriadis", "Christoph R. Sinning", "Renate B. Schnabel", "Edith Lubos", "Karl J. Lackner", "Heidi Rossmann", "Thomas Munzel", "Augusto Rendon", "Cardiogenics Consortium", "Jeanette Erdmann", "Panos Deloukas", "Christian Hengstenberg", "Patrick Diemert", "Gilles Montalescot", "Willem H. Ouwehand", "Nilesh J. Samani", "Heribert Schunkert", "David-Alexandre Trégouët", "Andreas Ziegler", "Alison H. Goodall", "François Cambien", "Laurence Tiret", "Stefan Blankenberg"], "doi"=>"https://dx.doi.org/10.1371/journal.pgen.1002367.g003", "stats"=>{"downloads"=>0, "page_views"=>13, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Box_plots_showing_the_association_of_rs653178_at_locus_12q24_SH2B3_with_CRIP1_expression_in_GHS_and_Cardiogenics_/377790", "title"=>"Box plots showing the association of rs653178 at locus 12q24 (<i>SH2B3</i>) with <i>CRIP1</i> expression in GHS and Cardiogenics.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-12-01 02:09:50"}
  • {"files"=>["https://ndownloader.figshare.com/files/707327"], "description"=>"<p>The graph shows the workflows used in parallel for expression data and genotype data. MDS: multidimensional scaling; SVD: singular value decomposition; ICA: independent component analysis; GO: gene ontology; MAF: minor allele frequency; HWE: Hardy-Weinberg equilibrium.</p>", "links"=>[], "tags"=>["genetics and genomics"], "article_id"=>377639, "categories"=>["Genetics"], "users"=>["Maxime Rotival", "Tanja Zeller", "Philipp S. Wild", "Seraya Maouche", "Silke Szymczak", "Arne Schillert", "Raphaele Castagné", "Arne Deiseroth", "Carole Proust", "Jessy Brocheton", "Tiphaine Godefroy", "Claire Perret", "Marine Germain", "Medea Eleftheriadis", "Christoph R. Sinning", "Renate B. Schnabel", "Edith Lubos", "Karl J. Lackner", "Heidi Rossmann", "Thomas Munzel", "Augusto Rendon", "Cardiogenics Consortium", "Jeanette Erdmann", "Panos Deloukas", "Christian Hengstenberg", "Patrick Diemert", "Gilles Montalescot", "Willem H. Ouwehand", "Nilesh J. Samani", "Heribert Schunkert", "David-Alexandre Trégouët", "Andreas Ziegler", "Alison H. Goodall", "François Cambien", "Laurence Tiret", "Stefan Blankenberg"], "doi"=>"https://dx.doi.org/10.1371/journal.pgen.1002367.g002", "stats"=>{"downloads"=>0, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Analysis_workflow_/377639", "title"=>"Analysis workflow.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-12-01 02:07:19"}
  • {"files"=>["https://ndownloader.figshare.com/files/358877", "https://ndownloader.figshare.com/files/358915", "https://ndownloader.figshare.com/files/358948", "https://ndownloader.figshare.com/files/358991", "https://ndownloader.figshare.com/files/359027", "https://ndownloader.figshare.com/files/359076", "https://ndownloader.figshare.com/files/359113", "https://ndownloader.figshare.com/files/359179", "https://ndownloader.figshare.com/files/359337", "https://ndownloader.figshare.com/files/359353", "https://ndownloader.figshare.com/files/359367", "https://ndownloader.figshare.com/files/359388", "https://ndownloader.figshare.com/files/359458", "https://ndownloader.figshare.com/files/359569"], "description"=>"<div><p>One major expectation from the transcriptome in humans is to characterize the biological basis of associations identified by genome-wide association studies. So far, few <em>cis</em> expression quantitative trait loci (eQTLs) have been reliably related to disease susceptibility. <em>Trans</em>-regulating mechanisms may play a more prominent role in disease susceptibility. We analyzed 12,808 genes detected in at least 5% of circulating monocyte samples from a population-based sample of 1,490 European unrelated subjects. We applied a method of extraction of expression patterns—independent component analysis—to identify sets of co-regulated genes. These patterns were then related to 675,350 SNPs to identify major <em>trans</em>-acting regulators. We detected three genomic regions significantly associated with co-regulated gene modules. Association of these loci with multiple expression traits was replicated in Cardiogenics, an independent study in which expression profiles of monocytes were available in 758 subjects. The locus 12q13 (lead SNP rs11171739), previously identified as a type 1 diabetes locus, was associated with a pattern including two <em>cis</em> eQTLs, <em>RPS26</em> and <em>SUOX</em>, and 5 <em>trans</em> eQTLs, one of which (<em>MADCAM1</em>) is a potential candidate for mediating T1D susceptibility. The locus 12q24 (lead SNP rs653178), which has demonstrated extensive disease pleiotropy, including type 1 diabetes, hypertension, and celiac disease, was associated to a pattern strongly correlating to blood pressure level. The strongest <em>trans</em> eQTL in this pattern was <em>CRIP1</em>, a known marker of cellular proliferation in cancer. The locus 12q15 (lead SNP rs11177644) was associated with a pattern driven by two <em>cis</em> eQTLs, <em>LYZ</em> and <em>YEATS4</em>, and including 34 <em>trans</em> eQTLs, several of them tumor-related genes. This study shows that a method exploiting the structure of co-expressions among genes can help identify genomic regions involved in <em>trans</em> regulation of sets of genes and can provide clues for understanding the mechanisms linking genome-wide association loci to disease.</p> </div>", "links"=>[], "tags"=>["integrating", "genome-wide", "variations", "monocyte", "reveals", "modules", "humans"], "article_id"=>130933, "categories"=>["Genetics"], "users"=>["Maxime Rotival", "Tanja Zeller", "Philipp S. Wild", "Seraya Maouche", "Silke Szymczak", "Arne Schillert", "Raphaele Castagné", "Arne Deiseroth", "Carole Proust", "Jessy Brocheton", "Tiphaine Godefroy", "Claire Perret", "Marine Germain", "Medea Eleftheriadis", "Christoph R. Sinning", "Renate B. Schnabel", "Edith Lubos", "Karl J. Lackner", "Heidi Rossmann", "Thomas Munzel", "Augusto Rendon", "Cardiogenics Consortium", "Jeanette Erdmann", "Panos Deloukas", "Christian Hengstenberg", "Patrick Diemert", "Gilles Montalescot", "Willem H. Ouwehand", "Nilesh J. Samani", "Heribert Schunkert", "David-Alexandre Trégouët", "Andreas Ziegler", "Alison H. Goodall", "François Cambien", "Laurence Tiret", "Stefan Blankenberg"], "doi"=>["https://dx.doi.org/10.1371/journal.pgen.1002367.s001", "https://dx.doi.org/10.1371/journal.pgen.1002367.s002", "https://dx.doi.org/10.1371/journal.pgen.1002367.s003", "https://dx.doi.org/10.1371/journal.pgen.1002367.s004", "https://dx.doi.org/10.1371/journal.pgen.1002367.s005", "https://dx.doi.org/10.1371/journal.pgen.1002367.s006", "https://dx.doi.org/10.1371/journal.pgen.1002367.s007", "https://dx.doi.org/10.1371/journal.pgen.1002367.s008", "https://dx.doi.org/10.1371/journal.pgen.1002367.s009", "https://dx.doi.org/10.1371/journal.pgen.1002367.s010", "https://dx.doi.org/10.1371/journal.pgen.1002367.s011", "https://dx.doi.org/10.1371/journal.pgen.1002367.s012", "https://dx.doi.org/10.1371/journal.pgen.1002367.s013", "https://dx.doi.org/10.1371/journal.pgen.1002367.s014"], "stats"=>{"downloads"=>33, "page_views"=>13, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Integrating_Genome_Wide_Genetic_Variations_and_Monocyte_Expression_Data_Reveals_Trans_Regulated_Gene_Modules_in_Humans/130933", "title"=>"Integrating Genome-Wide Genetic Variations and Monocyte Expression Data Reveals <em>Trans</em>-Regulated Gene Modules in Humans", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2011-12-01 00:15:33"}
  • {"files"=>["https://ndownloader.figshare.com/files/707172"], "description"=>"<p>Data are represented using a heat color map, from dark blue (minimum) to dark red (maximum). ICA splits the gene expression matrix <i>X</i> into a matrix product <i>X</i> = <i>SA</i>, introducing two new components (“signatures”, contained in the columns of <i>S</i>) with minimal statistical dependencies between them. These components may be viewed as reflecting hidden underlying processes influencing gene expressions (<i>P1</i> and <i>P2</i>). In the example, <i>P1</i> influences 3 genes and <i>P2</i> influences 4 genes. Gene <i>G3</i> is influenced by both processes, which is reflected by the dark red and dark blue colors in the row corresponding to <i>G3 i</i>n matrix <i>S</i>. The rows of matrix <i>A</i> represent the levels of the two components in individuals (“patterns”). The same data are shown as continuous profiles below. Individuals have been ordered to show that when levels of pattern 1 increase, levels of pattern 2 decrease, resulting in a negative correlation between the two patterns.</p>", "links"=>[], "tags"=>["ica"], "article_id"=>377492, "categories"=>["Genetics"], "users"=>["Maxime Rotival", "Tanja Zeller", "Philipp S. Wild", "Seraya Maouche", "Silke Szymczak", "Arne Schillert", "Raphaele Castagné", "Arne Deiseroth", "Carole Proust", "Jessy Brocheton", "Tiphaine Godefroy", "Claire Perret", "Marine Germain", "Medea Eleftheriadis", "Christoph R. Sinning", "Renate B. Schnabel", "Edith Lubos", "Karl J. Lackner", "Heidi Rossmann", "Thomas Munzel", "Augusto Rendon", "Cardiogenics Consortium", "Jeanette Erdmann", "Panos Deloukas", "Christian Hengstenberg", "Patrick Diemert", "Gilles Montalescot", "Willem H. Ouwehand", "Nilesh J. Samani", "Heribert Schunkert", "David-Alexandre Trégouët", "Andreas Ziegler", "Alison H. Goodall", "François Cambien", "Laurence Tiret", "Stefan Blankenberg"], "doi"=>"https://dx.doi.org/10.1371/journal.pgen.1002367.g001", "stats"=>{"downloads"=>1, "page_views"=>10, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_An_example_of_the_ICA_method_with_K_2_K_number_of_independent_components_/377492", "title"=>"An example of the ICA method with <i>K</i> = 2 (<i>K</i>, number of independent components).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-12-01 02:04:52"}
  • {"files"=>["https://ndownloader.figshare.com/files/707609"], "description"=>"<p>ICA patterns (rows) are ordered by decreasing explained variance.</p>", "links"=>[], "tags"=>["pearson", "coefficients", "patterns", "ica", "module", "eigengenes"], "article_id"=>377917, "categories"=>["Genetics"], "users"=>["Maxime Rotival", "Tanja Zeller", "Philipp S. Wild", "Seraya Maouche", "Silke Szymczak", "Arne Schillert", "Raphaele Castagné", "Arne Deiseroth", "Carole Proust", "Jessy Brocheton", "Tiphaine Godefroy", "Claire Perret", "Marine Germain", "Medea Eleftheriadis", "Christoph R. Sinning", "Renate B. Schnabel", "Edith Lubos", "Karl J. Lackner", "Heidi Rossmann", "Thomas Munzel", "Augusto Rendon", "Cardiogenics Consortium", "Jeanette Erdmann", "Panos Deloukas", "Christian Hengstenberg", "Patrick Diemert", "Gilles Montalescot", "Willem H. Ouwehand", "Nilesh J. Samani", "Heribert Schunkert", "David-Alexandre Trégouët", "Andreas Ziegler", "Alison H. Goodall", "François Cambien", "Laurence Tiret", "Stefan Blankenberg"], "doi"=>"https://dx.doi.org/10.1371/journal.pgen.1002367.g004", "stats"=>{"downloads"=>0, "page_views"=>1, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Heatmap_of_absolute_Pearson_correlation_coefficients_between_expression_patterns_obtained_by_ICA_and_module_eigengenes_ME_obtained_by_WGCNA_/377917", "title"=>"Heatmap of absolute Pearson correlation coefficients between expression patterns obtained by ICA and module eigengenes (ME) obtained by WGCNA.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-12-01 02:11:57"}
  • {"files"=>["https://ndownloader.figshare.com/files/707932"], "description"=>"a<p><i>P</i>-values<10<sup>−7</sup> were considered for SNP-pattern associations;</p>b<p><i>P</i>-values<10<sup>−5</sup> were considered for associations between the SNP and expression traits within the module;</p>c<p><i>P</i>-values<1.15×10<sup>−9</sup> were considered for the enrichment in expression traits associated to the SNP within the module.</p>", "links"=>[], "tags"=>["snps"], "article_id"=>378254, "categories"=>["Genetics"], "users"=>["Maxime Rotival", "Tanja Zeller", "Philipp S. Wild", "Seraya Maouche", "Silke Szymczak", "Arne Schillert", "Raphaele Castagné", "Arne Deiseroth", "Carole Proust", "Jessy Brocheton", "Tiphaine Godefroy", "Claire Perret", "Marine Germain", "Medea Eleftheriadis", "Christoph R. Sinning", "Renate B. Schnabel", "Edith Lubos", "Karl J. Lackner", "Heidi Rossmann", "Thomas Munzel", "Augusto Rendon", "Cardiogenics Consortium", "Jeanette Erdmann", "Panos Deloukas", "Christian Hengstenberg", "Patrick Diemert", "Gilles Montalescot", "Willem H. Ouwehand", "Nilesh J. Samani", "Heribert Schunkert", "David-Alexandre Trégouët", "Andreas Ziegler", "Alison H. Goodall", "François Cambien", "Laurence Tiret", "Stefan Blankenberg"], "doi"=>"https://dx.doi.org/10.1371/journal.pgen.1002367.t001", "stats"=>{"downloads"=>0, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Genome_wide_association_of_SNPs_with_patterns_/378254", "title"=>"Genome-wide association of SNPs with patterns.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2011-12-01 02:17:34"}
  • {"files"=>["https://ndownloader.figshare.com/files/707794"], "description"=>"<p>For each SNP, the best <i>P</i>-value over the 26 or 71 MEs and the 64 ICA patterns, respectively, is shown. A Sidak correction was applied to correct for the number of MEs (patterns, resp.) tested.</p>", "links"=>[], "tags"=>["comparing", "associations", "snps", "patterns", "ica", "module", "eigengenes", "wgcna", "default", "mes", "tuned", "parameters"], "article_id"=>378090, "categories"=>["Genetics"], "users"=>["Maxime Rotival", "Tanja Zeller", "Philipp S. Wild", "Seraya Maouche", "Silke Szymczak", "Arne Schillert", "Raphaele Castagné", "Arne Deiseroth", "Carole Proust", "Jessy Brocheton", "Tiphaine Godefroy", "Claire Perret", "Marine Germain", "Medea Eleftheriadis", "Christoph R. Sinning", "Renate B. Schnabel", "Edith Lubos", "Karl J. Lackner", "Heidi Rossmann", "Thomas Munzel", "Augusto Rendon", "Cardiogenics Consortium", "Jeanette Erdmann", "Panos Deloukas", "Christian Hengstenberg", "Patrick Diemert", "Gilles Montalescot", "Willem H. Ouwehand", "Nilesh J. Samani", "Heribert Schunkert", "David-Alexandre Trégouët", "Andreas Ziegler", "Alison H. Goodall", "François Cambien", "Laurence Tiret", "Stefan Blankenberg"], "doi"=>"https://dx.doi.org/10.1371/journal.pgen.1002367.g005", "stats"=>{"downloads"=>0, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Quantile_8211_quantile_plot_comparing_the_associations_of_675_350_SNPs_with_patterns_obtained_by_ICA_64_patterns_8211_red_and_module_eigengenes_MEs_obtained_by_WGCNA_with_default_26_MEs_8211_black_or_tuned_parameters_71_MEs_8211_blue_/378090", "title"=>"Quantile–quantile plot comparing the associations of 675,350 SNPs with patterns obtained by ICA (64 patterns – red) and module eigengenes (MEs) obtained by WGCNA with default (26 MEs – black ) or tuned parameters (71 MEs – blue).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-12-01 02:14:50"}

PMC Usage Stats | Further Information

  • {"scanned-page-browse"=>"0", "month"=>"12", "cited-by"=>"0", "abstract"=>"2", "full-text"=>"82", "unique-ip"=>"78", "pdf"=>"51", "year"=>"2011", "figure"=>"11", "scanned-summary"=>"0", "supp-data"=>"2"}
  • {"scanned-page-browse"=>"0", "month"=>"1", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"51", "unique-ip"=>"64", "pdf"=>"41", "year"=>"2012", "figure"=>"15", "scanned-summary"=>"0", "supp-data"=>"1"}
  • {"month"=>"2", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"66", "year"=>"2012", "pdf"=>"30", "unique-ip"=>"61", "figure"=>"19", "scanned-summary"=>"0", "supp-data"=>"8"}
  • {"scanned-page-browse"=>"0", "month"=>"3", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"64", "unique-ip"=>"66", "pdf"=>"45", "year"=>"2012", "figure"=>"11", "scanned-summary"=>"0", "supp-data"=>"17"}
  • {"month"=>"4", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"2", "full-text"=>"47", "year"=>"2012", "pdf"=>"26", "unique-ip"=>"55", "figure"=>"16", "scanned-summary"=>"0", "supp-data"=>"4"}
  • {"scanned-page-browse"=>"0", "month"=>"5", "cited-by"=>"0", "abstract"=>"3", "full-text"=>"36", "unique-ip"=>"41", "pdf"=>"24", "year"=>"2012", "figure"=>"11", "scanned-summary"=>"0", "supp-data"=>"2"}
  • {"month"=>"6", "scanned-page-browse"=>"0", "cited-by"=>"2", "abstract"=>"0", "full-text"=>"33", "year"=>"2012", "pdf"=>"27", "unique-ip"=>"34", "figure"=>"4", "scanned-summary"=>"0", "supp-data"=>"9"}
  • {"unique-ip"=>"32", "full-text"=>"33", "pdf"=>"16", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"7"}
  • {"unique-ip"=>"34", "full-text"=>"41", "pdf"=>"15", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"12", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2012", "month"=>"8"}
  • {"unique-ip"=>"31", "full-text"=>"29", "pdf"=>"12", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"9"}
  • {"unique-ip"=>"39", "full-text"=>"43", "pdf"=>"40", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"7", "cited-by"=>"0", "year"=>"2012", "month"=>"10"}
  • {"unique-ip"=>"27", "full-text"=>"26", "pdf"=>"11", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"12"}
  • {"unique-ip"=>"27", "full-text"=>"34", "pdf"=>"16", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2013", "month"=>"1"}
  • {"unique-ip"=>"22", "full-text"=>"28", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2013", "month"=>"2"}
  • {"unique-ip"=>"17", "full-text"=>"15", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2013", "month"=>"3"}
  • {"unique-ip"=>"25", "full-text"=>"27", "pdf"=>"10", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"12", "supp-data"=>"25", "cited-by"=>"0", "year"=>"2013", "month"=>"4"}
  • {"unique-ip"=>"32", "full-text"=>"32", "pdf"=>"13", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"9", "supp-data"=>"2", "cited-by"=>"1", "year"=>"2012", "month"=>"11"}
  • {"unique-ip"=>"23", "full-text"=>"31", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"5"}
  • {"unique-ip"=>"18", "full-text"=>"16", "pdf"=>"9", "abstract"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"13", "cited-by"=>"0", "year"=>"2013", "month"=>"6"}
  • {"unique-ip"=>"24", "full-text"=>"19", "pdf"=>"11", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"7"}
  • {"unique-ip"=>"17", "full-text"=>"18", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"8"}
  • {"unique-ip"=>"30", "full-text"=>"77", "pdf"=>"11", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"13", "cited-by"=>"0", "year"=>"2013", "month"=>"9"}
  • {"unique-ip"=>"22", "full-text"=>"28", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"5", "cited-by"=>"0", "year"=>"2013", "month"=>"10"}
  • {"unique-ip"=>"13", "full-text"=>"15", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2013", "month"=>"11"}
  • {"unique-ip"=>"12", "full-text"=>"11", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"12"}
  • {"unique-ip"=>"28", "full-text"=>"24", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"1"}
  • {"unique-ip"=>"21", "full-text"=>"28", "pdf"=>"11", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2014", "month"=>"2"}
  • {"unique-ip"=>"19", "full-text"=>"17", "pdf"=>"4", "abstract"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2014", "month"=>"3"}
  • {"unique-ip"=>"16", "full-text"=>"13", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2014", "month"=>"5"}
  • {"unique-ip"=>"22", "full-text"=>"20", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"6"}
  • {"unique-ip"=>"16", "full-text"=>"20", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"4"}
  • {"unique-ip"=>"31", "full-text"=>"24", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2014", "month"=>"7"}
  • {"unique-ip"=>"30", "full-text"=>"30", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2014", "month"=>"8"}
  • {"unique-ip"=>"32", "full-text"=>"26", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"4", "cited-by"=>"0", "year"=>"2014", "month"=>"9"}
  • {"unique-ip"=>"50", "full-text"=>"33", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"9", "supp-data"=>"28", "cited-by"=>"2", "year"=>"2014", "month"=>"10"}
  • {"unique-ip"=>"35", "full-text"=>"31", "pdf"=>"6", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"3", "cited-by"=>"2", "year"=>"2014", "month"=>"11"}
  • {"unique-ip"=>"20", "full-text"=>"23", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2014", "month"=>"12"}
  • {"unique-ip"=>"18", "full-text"=>"19", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2015", "month"=>"1"}
  • {"unique-ip"=>"14", "full-text"=>"12", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2015", "month"=>"2"}
  • {"unique-ip"=>"16", "full-text"=>"14", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2015", "month"=>"3"}
  • {"unique-ip"=>"16", "full-text"=>"18", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"14", "cited-by"=>"1", "year"=>"2015", "month"=>"4"}
  • {"unique-ip"=>"14", "full-text"=>"18", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2015", "month"=>"5"}
  • {"unique-ip"=>"13", "full-text"=>"10", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"6"}
  • {"unique-ip"=>"20", "full-text"=>"25", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2015", "month"=>"7"}
  • {"unique-ip"=>"14", "full-text"=>"16", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2015", "month"=>"8"}
  • {"unique-ip"=>"26", "full-text"=>"31", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2015", "month"=>"9"}
  • {"unique-ip"=>"23", "full-text"=>"17", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2015", "month"=>"10"}
  • {"unique-ip"=>"18", "full-text"=>"17", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"11"}
  • {"unique-ip"=>"13", "full-text"=>"14", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"12"}
  • {"unique-ip"=>"11", "full-text"=>"9", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2016", "month"=>"1"}
  • {"unique-ip"=>"11", "full-text"=>"11", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"2"}
  • {"unique-ip"=>"16", "full-text"=>"17", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2016", "month"=>"3"}
  • {"unique-ip"=>"8", "full-text"=>"6", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2016", "month"=>"4"}
  • {"unique-ip"=>"10", "full-text"=>"8", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2016", "month"=>"5"}
  • {"unique-ip"=>"11", "full-text"=>"12", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"6"}
  • {"unique-ip"=>"10", "full-text"=>"6", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"7"}
  • {"unique-ip"=>"12", "full-text"=>"9", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"8"}
  • {"unique-ip"=>"13", "full-text"=>"12", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2016", "month"=>"9"}
  • {"unique-ip"=>"12", "full-text"=>"9", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"10"}
  • {"unique-ip"=>"11", "full-text"=>"14", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"11"}
  • {"unique-ip"=>"12", "full-text"=>"11", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"10", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2016", "month"=>"12"}
  • {"unique-ip"=>"9", "full-text"=>"8", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"13", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"1"}
  • {"unique-ip"=>"14", "full-text"=>"14", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2017", "month"=>"2"}
  • {"unique-ip"=>"18", "full-text"=>"18", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2017", "month"=>"3"}
  • {"unique-ip"=>"14", "full-text"=>"15", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2017", "month"=>"4"}
  • {"unique-ip"=>"8", "full-text"=>"8", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"5"}
  • {"unique-ip"=>"14", "full-text"=>"15", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"6"}
  • {"unique-ip"=>"13", "full-text"=>"16", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"7"}
  • {"unique-ip"=>"6", "full-text"=>"6", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"8"}
  • {"unique-ip"=>"8", "full-text"=>"6", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2017", "month"=>"9"}
  • {"unique-ip"=>"4", "full-text"=>"5", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"10"}
  • {"unique-ip"=>"15", "full-text"=>"30", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"11"}
  • {"unique-ip"=>"12", "full-text"=>"13", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2017", "month"=>"12"}
  • {"unique-ip"=>"14", "full-text"=>"13", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"1"}
  • {"unique-ip"=>"1", "full-text"=>"0", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"2"}
  • {"unique-ip"=>"19", "full-text"=>"22", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2018", "month"=>"3"}
  • {"unique-ip"=>"26", "full-text"=>"30", "pdf"=>"8", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2019", "month"=>"1"}
  • {"unique-ip"=>"7", "full-text"=>"8", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"4"}
  • {"unique-ip"=>"26", "full-text"=>"23", "pdf"=>"11", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"21", "cited-by"=>"0", "year"=>"2018", "month"=>"5"}
  • {"unique-ip"=>"15", "full-text"=>"15", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"1", "year"=>"2018", "month"=>"6"}
  • {"unique-ip"=>"16", "full-text"=>"7", "pdf"=>"6", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"7", "cited-by"=>"0", "year"=>"2018", "month"=>"7"}
  • {"unique-ip"=>"14", "full-text"=>"11", "pdf"=>"6", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"4", "cited-by"=>"0", "year"=>"2018", "month"=>"8"}
  • {"unique-ip"=>"14", "full-text"=>"13", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"5", "cited-by"=>"0", "year"=>"2018", "month"=>"9"}
  • {"unique-ip"=>"12", "full-text"=>"11", "pdf"=>"7", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"10"}
  • {"unique-ip"=>"18", "full-text"=>"25", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"17", "cited-by"=>"0", "year"=>"2018", "month"=>"11"}
  • {"unique-ip"=>"12", "full-text"=>"13", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"12"}
  • {"unique-ip"=>"22", "full-text"=>"28", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"5", "cited-by"=>"0", "year"=>"2019", "month"=>"2"}
  • {"unique-ip"=>"19", "full-text"=>"14", "pdf"=>"6", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"3"}
  • {"unique-ip"=>"17", "full-text"=>"33", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2019", "month"=>"4"}
  • {"unique-ip"=>"24", "full-text"=>"24", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"10", "supp-data"=>"3", "cited-by"=>"1", "year"=>"2019", "month"=>"5"}
  • {"unique-ip"=>"15", "full-text"=>"17", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"8"}
  • {"unique-ip"=>"27", "full-text"=>"26", "pdf"=>"6", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"9"}
  • {"unique-ip"=>"20", "full-text"=>"21", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"10"}
  • {"unique-ip"=>"11", "full-text"=>"8", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"12"}
  • {"unique-ip"=>"24", "full-text"=>"23", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"2"}
  • {"unique-ip"=>"18", "full-text"=>"17", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"3"}
  • {"unique-ip"=>"17", "full-text"=>"16", "pdf"=>"6", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2020", "month"=>"4"}
  • {"unique-ip"=>"21", "full-text"=>"19", "pdf"=>"7", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2020", "month"=>"5"}
  • {"unique-ip"=>"23", "full-text"=>"25", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"6"}
  • {"unique-ip"=>"18", "full-text"=>"21", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"16", "cited-by"=>"0", "year"=>"2020", "month"=>"7"}
  • {"unique-ip"=>"19", "full-text"=>"22", "pdf"=>"8", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"14", "cited-by"=>"1", "year"=>"2020", "month"=>"8"}
  • {"unique-ip"=>"36", "full-text"=>"49", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"7", "cited-by"=>"0", "year"=>"2020", "month"=>"9"}

Relative Metric

{"start_date"=>"2011-01-01T00:00:00Z", "end_date"=>"2011-12-31T00:00:00Z", "subject_areas"=>[{"subject_area"=>"/Biology and life sciences", "average_usage"=>[304, 568, 702, 818, 927, 1027, 1118, 1206, 1285, 1357, 1427, 1500, 1564, 1636, 1705, 1773, 1840, 1909, 1974, 2039, 2106, 2170, 2234, 2296, 2358, 2423, 2484, 2546, 2606, 2673, 2734, 2795, 2857, 2921, 2984, 3046, 3100]}, {"subject_area"=>"/Biology and life sciences/Anatomy and physiology", "average_usage"=>[298, 559, 690, 805, 916, 1018, 1115, 1201, 1283, 1356, 1425, 1498, 1565, 1635, 1703, 1767, 1835, 1902, 1962, 2027, 2089, 2150, 2210, 2265]}, {"subject_area"=>"/Biology and life sciences/Cell biology", "average_usage"=>[289, 559, 699, 817, 931, 1031, 1127, 1214, 1297, 1370, 1444, 1515, 1584, 1656, 1726, 1797, 1862, 1930, 1996, 2061, 2125, 2190, 2250, 2311, 2373, 2435, 2496, 2563, 2630, 2692, 2760, 2824, 2898, 2960, 3019, 3089, 3143]}, {"subject_area"=>"/Biology and life sciences/Genetics", "average_usage"=>[308, 576, 718, 839, 960, 1061, 1156, 1249, 1331, 1408, 1484, 1558, 1625, 1698, 1767, 1842, 1912, 1990, 2058, 2128, 2183, 2259, 2317, 2378, 2436, 2488, 2552, 2627, 2692, 2759, 2820, 2881, 2940, 3001, 3061, 3117, 3164]}, {"subject_area"=>"/Medicine and health sciences/Anatomy and physiology", "average_usage"=>[296, 554, 686, 802, 910, 1014, 1104, 1195, 1277, 1349, 1419, 1483, 1551, 1620, 1690, 1757, 1820, 1888, 1957, 2017, 2081, 2140, 2202, 2259]}]}

F1000Prime | Further Information

Loading … Spinner
There are currently no alerts