Patterns of Ancestry, Signatures of Natural Selection, and Genetic Association with Stature in Western African Pygmies
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{"title"=>"Patterns of ancestry, signatures of natural selection, and genetic association with stature in Western African pygmies", "type"=>"journal", "authors"=>[{"first_name"=>"Joseph P.", "last_name"=>"Jarvis", "scopus_author_id"=>"8553993500"}, {"first_name"=>"Laura B.", "last_name"=>"Scheinfeldt", "scopus_author_id"=>"6507888492"}, {"first_name"=>"Sameer", "last_name"=>"Soi", "scopus_author_id"=>"30567862700"}, {"first_name"=>"Charla", "last_name"=>"Lambert", "scopus_author_id"=>"36545319100"}, {"first_name"=>"Larsson", "last_name"=>"Omberg", "scopus_author_id"=>"23028807900"}, {"first_name"=>"Bart", "last_name"=>"Ferwerda", "scopus_author_id"=>"23027393200"}, {"first_name"=>"Alain", "last_name"=>"Froment", "scopus_author_id"=>"7005494385"}, {"first_name"=>"Jean Marie", "last_name"=>"Bodo", "scopus_author_id"=>"6602403077"}, {"first_name"=>"William", "last_name"=>"Beggs", "scopus_author_id"=>"54903435300"}, {"first_name"=>"Gabriel", "last_name"=>"Hoffman", "scopus_author_id"=>"55155370900"}, {"first_name"=>"Jason", "last_name"=>"Mezey", "scopus_author_id"=>"6603453253"}, {"first_name"=>"Sarah A.", "last_name"=>"Tishkoff", "scopus_author_id"=>"6602129816"}], "year"=>2012, "source"=>"PLoS Genetics", "identifiers"=>{"issn"=>"15537390", "pui"=>"364739000", "pmid"=>"22570615", "isbn"=>"1553-7404", "doi"=>"10.1371/journal.pgen.1002641", "arxiv"=>"ArXiv ID", "sgr"=>"84860557929", "scopus"=>"2-s2.0-84860557929"}, "id"=>"10d59584-ae2e-343a-a792-bdaa98c4b238", "abstract"=>"African Pygmy groups show a distinctive pattern of phenotypic variation, including short stature, which is thought to reflect past adaptation to a tropical environment: Here, we analyze Illumina 1M SNP array data in three Western Pygmy populations from Cameroon and three neighboring Bantu-speaking agricultural populations with whom they have admixed. We infer genome-wide ancestry, scan for signals of positive selection, and perform targeted genetic association with measured height variation. We identify multiple regions throughout the genome that may have played a role in adaptive evolution, many of which contain loci with roles in growth hormone, insulin, and insulin-like growth factor signaling pathways, as well as immunity and neuroendocrine signaling involved in reproduction and metabolism. The most striking results are found on chromosome 3, which harbors a cluster of selection and association signals between approximately 45 and 60 Mb. This region also includes the positional candidate genes DOCK3, which is known to be associated with height variation in Europeans, and CISH, a negative regulator of cytokine signaling known to inhibit growth hormone-stimulated STAT5 signaling. Finally, pathway analysis for genes near the strongest signals of association with height indicates enrichment for loci involved in insulin and insulin-like growth factor signaling.", "link"=>"http://www.mendeley.com/research/patterns-ancestry-signatures-natural-selection-genetic-association-stature-western-african-pygmies", "reader_count"=>182, "reader_count_by_academic_status"=>{"Unspecified"=>7, "Professor > Associate Professor"=>11, "Librarian"=>3, "Student > Doctoral Student"=>7, "Researcher"=>47, "Student > Ph. D. Student"=>52, "Student > Postgraduate"=>10, "Other"=>6, "Student > Master"=>11, "Student > Bachelor"=>12, "Lecturer"=>2, "Lecturer > Senior Lecturer"=>3, "Professor"=>11}, "reader_count_by_user_role"=>{"Unspecified"=>7, "Professor > Associate Professor"=>11, "Librarian"=>3, "Student > Doctoral Student"=>7, "Researcher"=>47, "Student > Ph. D. Student"=>52, "Student > Postgraduate"=>10, "Other"=>6, "Student > Master"=>11, "Student > Bachelor"=>12, "Lecturer"=>2, "Lecturer > Senior Lecturer"=>3, "Professor"=>11}, "reader_count_by_subject_area"=>{"Unspecified"=>10, "Environmental Science"=>2, "Biochemistry, Genetics and Molecular Biology"=>22, "Agricultural and Biological Sciences"=>121, "Medicine and Dentistry"=>8, "Arts and Humanities"=>2, "Psychology"=>2, "Social Sciences"=>11, "Computer Science"=>1, "Immunology and Microbiology"=>2, "Earth and Planetary Sciences"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>8}, "Social Sciences"=>{"Social Sciences"=>11}, "Psychology"=>{"Psychology"=>2}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>2}, "Earth and Planetary Sciences"=>{"Earth and Planetary Sciences"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>121}, "Computer Science"=>{"Computer Science"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>22}, "Unspecified"=>{"Unspecified"=>10}, "Environmental Science"=>{"Environmental Science"=>2}, "Arts and Humanities"=>{"Arts and Humanities"=>2}}, "reader_count_by_country"=>{"Canada"=>1, "Netherlands"=>1, "Austria"=>1, "Belgium"=>1, "United States"=>8, "Brazil"=>1, "South Africa"=>1, "United Kingdom"=>2, "Italy"=>1, "France"=>2, "Switzerland"=>1, "Indonesia"=>1}, "group_count"=>3}

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/646279"], "description"=>"<p>A) Genome-wide blocks of Pygmy and Bantu ancestry in Pygmy individuals. B) Blocks of Pygmy and Bantu ancestry in Pygmy individuals for chromosome 3. Shades of blue represent Pygmy ancestry and shades of red admixed Bantu ancestry. Shades are determined by the posterior probability of the estimates; darker colors indicate greater confidence. Each individual is represented by two horizontal rows (one for each haploid genome) and columns represent each window in the genome. Inferred percent Pygmy ancestry for each window is given below. Using SupportMix analysis, we determined the average ancestry block sizes in Pygmies to be 1.7+/−2.4 Mb for Pygmy ancestry, and 3.1+/−4.6 Mb for Bantu ancestry.</p>", "links"=>[], "tags"=>["ancestry"], "article_id"=>316760, "categories"=>["Genetics", "Evolutionary Biology"], "users"=>["Joseph P. Jarvis", "Laura B. Scheinfeldt", "Sameer Soi", "Charla Lambert", "Larsson Omberg", "Bart Ferwerda", "Alain Froment", "Jean-Marie Bodo", "William Beggs", "Gabriel Hoffman", "Jason Mezey", "Sarah A. Tishkoff"], "doi"=>"https://dx.doi.org/10.1371/journal.pgen.1002641.g002", "stats"=>{"downloads"=>4, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Results_from_local_ancestry_inference_/316760", "title"=>"Results from local ancestry inference.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2012-04-26 01:52:40"}
  • {"files"=>["https://ndownloader.figshare.com/files/646073"], "description"=>"<p>Plots of principal components A) 1 versus 2 and B) 2 versus 3 calculated using 1M SNP data from 67 Pygmy and 58 Bantu samples. The proportion of variance explained by PCs 1, 2, and 3 is 0.245, 0.0192, and 0.0109, respectively. The three Pygmy ethnic groups are clearly distinguished from their neighboring Bantu populations by the first two PCs, while the third differentiates the three Pygmy groups from one another. C) Regression of height on Pygmy ancestry inferred using STRUCTURE (K = 2). Higher levels of Pygmy ancestry are associated with shorter stature. The trend line intersects the intercept from the full model and has a slope equal to the regression coefficient for percent ancestry. D) Visualization of percent ancestry inferred using STRUCTURE at K = 2, 3, and 4.</p>", "links"=>[], "tags"=>["genetics and genomics", "Evolutionary biology"], "article_id"=>316556, "categories"=>["Genetics", "Evolutionary Biology"], "users"=>["Joseph P. Jarvis", "Laura B. Scheinfeldt", "Sameer Soi", "Charla Lambert", "Larsson Omberg", "Bart Ferwerda", "Alain Froment", "Jean-Marie Bodo", "William Beggs", "Gabriel Hoffman", "Jason Mezey", "Sarah A. Tishkoff"], "doi"=>"https://dx.doi.org/10.1371/journal.pgen.1002641.g001", "stats"=>{"downloads"=>4, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Admixture_and_population_structure_/316556", "title"=>"Admixture and population structure.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2012-04-26 01:49:16"}
  • {"files"=>["https://ndownloader.figshare.com/files/646413"], "description"=>"<p>Blocks of high genome-wide density based on SNPs/Mb for F<sub>ST</sub> (top half of each chromosome) and Pygmy LSBL SNPs (bottom half of each chromosome) are shown. Also shown are XP-EHH signals >5.0 in the Pygmy (Black) and Bantu (Red). The only genomic location showing all three signals occurs on chromosome 3 roughly between 45 and 60 Mb. iHS results for this region are given in <a href=\"http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1002641#pgen-1002641-g004\" target=\"_blank\">Figure 4C and 4D</a>.</p>", "links"=>[], "tags"=>["clusters", "signals"], "article_id"=>316900, "categories"=>["Genetics", "Evolutionary Biology"], "users"=>["Joseph P. Jarvis", "Laura B. Scheinfeldt", "Sameer Soi", "Charla Lambert", "Larsson Omberg", "Bart Ferwerda", "Alain Froment", "Jean-Marie Bodo", "William Beggs", "Gabriel Hoffman", "Jason Mezey", "Sarah A. Tishkoff"], "doi"=>"https://dx.doi.org/10.1371/journal.pgen.1002641.g003", "stats"=>{"downloads"=>0, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Genome_wide_clusters_of_signals_of_natural_selection_in_Pygmies_/316900", "title"=>"Genome-wide clusters of signals of natural selection in Pygmies.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2012-04-26 01:55:00"}
  • {"files"=>["https://ndownloader.figshare.com/files/333411", "https://ndownloader.figshare.com/files/333451", "https://ndownloader.figshare.com/files/333507", "https://ndownloader.figshare.com/files/333560", "https://ndownloader.figshare.com/files/333653", "https://ndownloader.figshare.com/files/333710", "https://ndownloader.figshare.com/files/333747", "https://ndownloader.figshare.com/files/333821", "https://ndownloader.figshare.com/files/333861", "https://ndownloader.figshare.com/files/333876", "https://ndownloader.figshare.com/files/333888", "https://ndownloader.figshare.com/files/333911", "https://ndownloader.figshare.com/files/333930", "https://ndownloader.figshare.com/files/333946", "https://ndownloader.figshare.com/files/333971", "https://ndownloader.figshare.com/files/333985", "https://ndownloader.figshare.com/files/334010", "https://ndownloader.figshare.com/files/334061", "https://ndownloader.figshare.com/files/334079", "https://ndownloader.figshare.com/files/334099", "https://ndownloader.figshare.com/files/334116"], "description"=>"<div><p>African Pygmy groups show a distinctive pattern of phenotypic variation, including short stature, which is thought to reflect past adaptation to a tropical environment. Here, we analyze Illumina 1M SNP array data in three Western Pygmy populations from Cameroon and three neighboring Bantu-speaking agricultural populations with whom they have admixed. We infer genome-wide ancestry, scan for signals of positive selection, and perform targeted genetic association with measured height variation. We identify multiple regions throughout the genome that may have played a role in adaptive evolution, many of which contain loci with roles in growth hormone, insulin, and insulin-like growth factor signaling pathways, as well as immunity and neuroendocrine signaling involved in reproduction and metabolism. The most striking results are found on chromosome 3, which harbors a cluster of selection and association signals between approximately 45 and 60 Mb. This region also includes the positional candidate genes <em>DOCK3</em>, which is known to be associated with height variation in Europeans, and <em>CISH</em>, a negative regulator of cytokine signaling known to inhibit growth hormone-stimulated <em>STAT5</em> signaling. Finally, pathway analysis for genes near the strongest signals of association with height indicates enrichment for loci involved in insulin and insulin-like growth factor signaling.</p> </div>", "links"=>[], "tags"=>["patterns", "signatures", "stature", "african", "pygmies"], "article_id"=>125844, "categories"=>["Genetics", "Evolutionary Biology"], "users"=>["Joseph P. Jarvis", "Laura B. Scheinfeldt", "Sameer Soi", "Charla Lambert", "Larsson Omberg", "Bart Ferwerda", "Alain Froment", "Jean-Marie Bodo", "William Beggs", "Gabriel Hoffman", "Jason Mezey", "Sarah A. Tishkoff"], "doi"=>["https://dx.doi.org/10.1371/journal.pgen.1002641.s001", "https://dx.doi.org/10.1371/journal.pgen.1002641.s002", "https://dx.doi.org/10.1371/journal.pgen.1002641.s003", "https://dx.doi.org/10.1371/journal.pgen.1002641.s004", "https://dx.doi.org/10.1371/journal.pgen.1002641.s005", "https://dx.doi.org/10.1371/journal.pgen.1002641.s006", "https://dx.doi.org/10.1371/journal.pgen.1002641.s007", "https://dx.doi.org/10.1371/journal.pgen.1002641.s008", "https://dx.doi.org/10.1371/journal.pgen.1002641.s009", "https://dx.doi.org/10.1371/journal.pgen.1002641.s010", "https://dx.doi.org/10.1371/journal.pgen.1002641.s011", "https://dx.doi.org/10.1371/journal.pgen.1002641.s012", "https://dx.doi.org/10.1371/journal.pgen.1002641.s013", "https://dx.doi.org/10.1371/journal.pgen.1002641.s014", "https://dx.doi.org/10.1371/journal.pgen.1002641.s015", "https://dx.doi.org/10.1371/journal.pgen.1002641.s016", "https://dx.doi.org/10.1371/journal.pgen.1002641.s017", "https://dx.doi.org/10.1371/journal.pgen.1002641.s018", "https://dx.doi.org/10.1371/journal.pgen.1002641.s019", "https://dx.doi.org/10.1371/journal.pgen.1002641.s020", "https://dx.doi.org/10.1371/journal.pgen.1002641.s021"], "stats"=>{"downloads"=>1, "page_views"=>17, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Patterns_of_Ancestry_Signatures_of_Natural_Selection_and_Genetic_Association_with_Stature_in_Western_African_Pygmies/125844", "title"=>"Patterns of Ancestry, Signatures of Natural Selection, and Genetic Association with Stature in Western African Pygmies", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2012-04-26 01:37:24"}
  • {"files"=>["https://ndownloader.figshare.com/files/646541"], "description"=>"<p>A) Results from F<sub>ST</sub> (Black) and Pygmy LSBL (Red) analysis. The region between ∼50 and 52 Mb contains the largest concentration in the genome of SNPs with scores in the 0.1% tail of the empirical distribution and contains the positional candidate genes <i>CISH</i>, <i>MAPKAP3</i>, and <i>DOCK3</i>. B) Results from XP-EHH analysis. Scores depicted in red show negative values indicating a signal in the Bantu samples, and scores in green show positive values indicating a signal in the Pygmy samples. C) Results from iHS analysis in the Bantu samples. D) Results from iHS analysis in the Pygmy samples. E) Results of association analysis for height (cm) using EMMAX with sex as a covariate. Two suggestive associations are evident. The first, at ∼46.5 Mb, occurs within the coding region of <i>LRRC2</i>. The second is a strong enrichment of association signals between ∼49.5 and 51 Mb directly corresponding to Pygmy-specific signals of positive selection in A–D, centered on the three positional candidates <i>CISH</i>, <i>MAPKAP3</i> and <i>DOCK3</i>.</p>", "links"=>[], "tags"=>["chromosome", "45", "60"], "article_id"=>317021, "categories"=>["Genetics", "Evolutionary Biology"], "users"=>["Joseph P. Jarvis", "Laura B. Scheinfeldt", "Sameer Soi", "Charla Lambert", "Larsson Omberg", "Bart Ferwerda", "Alain Froment", "Jean-Marie Bodo", "William Beggs", "Gabriel Hoffman", "Jason Mezey", "Sarah A. Tishkoff"], "doi"=>"https://dx.doi.org/10.1371/journal.pgen.1002641.g004", "stats"=>{"downloads"=>4, "page_views"=>2, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Signals_of_positive_selection_and_association_with_height_on_chromosome_3_between_45_and_60_Mb_/317021", "title"=>"Signals of positive selection and association with height on chromosome 3 between 45 and 60 Mb.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2012-04-26 01:57:01"}

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Relative Metric

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