Insertion/Deletion Polymorphisms in the ΔNp63 Promoter Are a Risk Factor for Bladder Exstrophy Epispadias Complex
Events
Loading … Spinner

Mendeley | Further Information

{"title"=>"Insertion/Deletion Polymorphisms in the ΔNp63 Promoter Are a Risk Factor for Bladder Exstrophy Epispadias Complex", "type"=>"journal", "authors"=>[{"first_name"=>"Simon", "last_name"=>"Wilkins", "scopus_author_id"=>"23098922000"}, {"first_name"=>"Ke Wei", "last_name"=>"Zhang", "scopus_author_id"=>"55547682400"}, {"first_name"=>"Istiak", "last_name"=>"Mahfuz", "scopus_author_id"=>"55331185500"}, {"first_name"=>"Renaud", "last_name"=>"Quantin", "scopus_author_id"=>"8719458200"}, {"first_name"=>"Nancy", "last_name"=>"D'Cruz", "scopus_author_id"=>"24337315800"}, {"first_name"=>"John", "last_name"=>"Hutson", "scopus_author_id"=>"35253772000"}, {"first_name"=>"Michael", "last_name"=>"Ee", "scopus_author_id"=>"55548143100"}, {"first_name"=>"Darius", "last_name"=>"Bagli", "scopus_author_id"=>"7003926713"}, {"first_name"=>"Karen", "last_name"=>"Aitken", "scopus_author_id"=>"35596755500"}, {"first_name"=>"Fion Nga Yin", "last_name"=>"Fong", "scopus_author_id"=>"36604299900"}, {"first_name"=>"Patrick Kwok Shing", "last_name"=>"Ng", "scopus_author_id"=>"13908200700"}, {"first_name"=>"Stephen Kwok Wing", "last_name"=>"Tsui", "scopus_author_id"=>"7004961364"}, {"first_name"=>"Wendy Yin Wan", "last_name"=>"Fung", "scopus_author_id"=>"55548100900"}, {"first_name"=>"Tahmina", "last_name"=>"Banu", "scopus_author_id"=>"11639268900"}, {"first_name"=>"Atul", "last_name"=>"Thakre", "scopus_author_id"=>"55548402400"}, {"first_name"=>"Kaid", "last_name"=>"Johar", "scopus_author_id"=>"57188546048"}, {"first_name"=>"Enrique", "last_name"=>"Jaureguizar", "scopus_author_id"=>"7003671760"}, {"first_name"=>"Long", "last_name"=>"Li", "scopus_author_id"=>"57196181109"}, {"first_name"=>"Wei", "last_name"=>"Cheng", "scopus_author_id"=>"56397446600"}], "year"=>2012, "source"=>"PLoS Genetics", "identifiers"=>{"issn"=>"15537390", "pui"=>"368067336", "sgr"=>"84872024958", "scopus"=>"2-s2.0-84872024958", "pmid"=>"23284286", "doi"=>"10.1371/journal.pgen.1003070"}, "id"=>"8e1e18e6-db31-3fcd-b61f-dfba5e51a47d", "abstract"=>"Bladder exstrophy epispadias complex (BEEC) is a severe congenital anomaly; however, the genetic and molecular mechanisms underlying the formation of BEEC remain unclear. TP63, a member of TP53 tumor suppressor gene family, is expressed in bladder urothelium and skin over the external genitalia during mammalian development. It plays a role in bladder development. We have previously shown that p63(-/-) mouse embryos developed a bladder exstrophy phenotype identical to human BEEC. We hypothesised that TP63 is involved in human BEEC pathogenesis. RNA was extracted from BEEC foreskin specimens and, as in mice, ΔNp63 was the predominant p63 isoform. ΔNp63 expression in the foreskin and bladder epithelium of BEEC patients was reduced. DNA was sequenced from 163 BEEC patients and 285 ethnicity-matched controls. No exon mutations were detected. Sequencing of the ΔNp63 promoter showed 7 single nucleotide polymorphisms and 4 insertion/deletion (indel) polymorphisms. Indel polymorphisms were associated with an increased risk of BEEC. Significantly the sites of indel polymorphisms differed between Caucasian and non-Caucasian populations. A 12-base-pair deletion was associated with an increased risk with only Caucasian patients (p = 0.0052 Odds Ratio (OR) = 18.33), whereas a 4-base-pair insertion was only associated with non-Caucasian patients (p = 0.0259 OR = 4.583). We found a consistent and statistically significant reduction in transcriptional efficiencies of the promoter sequences containing indel polymorphisms in luciferase assays. These findings suggest that indel polymorphisms of the ΔNp63 promoter lead to a reduction in p63 expression, which could lead to BEEC.", "link"=>"http://www.mendeley.com/research/insertiondeletion-polymorphisms-%CE%B4np63-promoter-risk-factor-bladder-exstrophy-epispadias-complex", "reader_count"=>11, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Librarian"=>1, "Researcher"=>2, "Student > Ph. D. Student"=>2, "Student > Postgraduate"=>1, "Student > Master"=>1, "Student > Bachelor"=>2, "Other"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Librarian"=>1, "Researcher"=>2, "Student > Ph. D. Student"=>2, "Student > Postgraduate"=>1, "Student > Master"=>1, "Student > Bachelor"=>2, "Other"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>3, "Biochemistry, Genetics and Molecular Biology"=>1, "Agricultural and Biological Sciences"=>3, "Medicine and Dentistry"=>3, "Energy"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>3}, "Energy"=>{"Energy"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>3}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>1}, "Unspecified"=>{"Unspecified"=>3}}, "reader_count_by_country"=>{"United States"=>1}, "group_count"=>1}

Scopus | Further Information

{"@_fa"=>"true", "link"=>[{"@_fa"=>"true", "@ref"=>"self", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/84872024958"}, {"@_fa"=>"true", "@ref"=>"author-affiliation", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/84872024958?field=author,affiliation"}, {"@_fa"=>"true", "@ref"=>"scopus", "@href"=>"https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84872024958&origin=inward"}, {"@_fa"=>"true", "@ref"=>"scopus-citedby", "@href"=>"https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=84872024958&origin=inward"}], "prism:url"=>"https://api.elsevier.com/content/abstract/scopus_id/84872024958", "dc:identifier"=>"SCOPUS_ID:84872024958", "eid"=>"2-s2.0-84872024958", "dc:title"=>"Insertion/Deletion Polymorphisms in the ΔNp63 Promoter Are a Risk Factor for Bladder Exstrophy Epispadias Complex", "dc:creator"=>"Wilkins S.", "prism:publicationName"=>"PLoS Genetics", "prism:issn"=>"15537390", "prism:eIssn"=>"15537404", "prism:volume"=>"8", "prism:issueIdentifier"=>"12", "prism:pageRange"=>nil, "prism:coverDate"=>"2012-01-01", "prism:coverDisplayDate"=>"December 2012", "prism:doi"=>"10.1371/journal.pgen.1003070", "citedby-count"=>"20", "affiliation"=>[{"@_fa"=>"true", "affilname"=>"Monash University", "affiliation-city"=>"Melbourne", "affiliation-country"=>"Australia"}, {"@_fa"=>"true", "affilname"=>"Hudson Institute of Medical Research", "affiliation-city"=>"Clayton", "affiliation-country"=>"Australia"}], "pubmed-id"=>"23284286", "prism:aggregationType"=>"Journal", "subtype"=>"ar", "subtypeDescription"=>"Article", "article-number"=>"e1003070", "source-id"=>"4000151808", "openaccess"=>"1", "openaccessFlag"=>true, "freetoread"=>{"value"=>[{"$"=>"all"}, {"$"=>"publisherfullgold"}, {"$"=>"repository"}, {"$"=>"repositoryvor"}, {"$"=>"repositoryam"}]}, "freetoreadLabel"=>{"value"=>[{"$"=>"All Open Access"}, {"$"=>"Gold"}, {"$"=>"Green"}]}}

Facebook

  • {"url"=>"http%3A%2F%2Fjournals.plos.org%2Fplosgenetics%2Farticle%3Fid%3D10.1371%252Fjournal.pgen.1003070", "share_count"=>8, "like_count"=>30, "comment_count"=>12, "click_count"=>0, "total_count"=>50}

Counter

  • {"month"=>"12", "year"=>"2012", "pdf_views"=>"39", "xml_views"=>"9", "html_views"=>"599"}
  • {"month"=>"1", "year"=>"2013", "pdf_views"=>"41", "xml_views"=>"2", "html_views"=>"630"}
  • {"month"=>"2", "year"=>"2013", "pdf_views"=>"13", "xml_views"=>"2", "html_views"=>"227"}
  • {"month"=>"3", "year"=>"2013", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"84"}
  • {"month"=>"4", "year"=>"2013", "pdf_views"=>"10", "xml_views"=>"1", "html_views"=>"102"}
  • {"month"=>"5", "year"=>"2013", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"48"}
  • {"month"=>"6", "year"=>"2013", "pdf_views"=>"64", "xml_views"=>"0", "html_views"=>"40"}
  • {"month"=>"7", "year"=>"2013", "pdf_views"=>"48", "xml_views"=>"2", "html_views"=>"34"}
  • {"month"=>"8", "year"=>"2013", "pdf_views"=>"32", "xml_views"=>"0", "html_views"=>"39"}
  • {"month"=>"9", "year"=>"2013", "pdf_views"=>"39", "xml_views"=>"0", "html_views"=>"68"}
  • {"month"=>"10", "year"=>"2013", "pdf_views"=>"7", "xml_views"=>"2", "html_views"=>"83"}
  • {"month"=>"11", "year"=>"2013", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"47"}
  • {"month"=>"12", "year"=>"2013", "pdf_views"=>"1", "xml_views"=>"1", "html_views"=>"21"}
  • {"month"=>"1", "year"=>"2014", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"35"}
  • {"month"=>"2", "year"=>"2014", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"30"}
  • {"month"=>"3", "year"=>"2014", "pdf_views"=>"1", "xml_views"=>"2", "html_views"=>"63"}
  • {"month"=>"4", "year"=>"2014", "pdf_views"=>"3", "xml_views"=>"1", "html_views"=>"49"}
  • {"month"=>"5", "year"=>"2014", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"49"}
  • {"month"=>"6", "year"=>"2014", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"29"}
  • {"month"=>"7", "year"=>"2014", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"40"}
  • {"month"=>"8", "year"=>"2014", "pdf_views"=>"2", "xml_views"=>"2", "html_views"=>"41"}
  • {"month"=>"9", "year"=>"2014", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"97"}
  • {"month"=>"10", "year"=>"2014", "pdf_views"=>"2", "xml_views"=>"2", "html_views"=>"39"}
  • {"month"=>"11", "year"=>"2014", "pdf_views"=>"3", "xml_views"=>"1", "html_views"=>"47"}
  • {"month"=>"12", "year"=>"2014", "pdf_views"=>"3", "xml_views"=>"2", "html_views"=>"37"}
  • {"month"=>"1", "year"=>"2015", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"25"}
  • {"month"=>"2", "year"=>"2015", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"22"}
  • {"month"=>"3", "year"=>"2015", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"46"}
  • {"month"=>"4", "year"=>"2015", "pdf_views"=>"5", "xml_views"=>"1", "html_views"=>"19"}
  • {"month"=>"5", "year"=>"2015", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"28"}
  • {"month"=>"6", "year"=>"2015", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"24"}
  • {"month"=>"7", "year"=>"2015", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"19"}
  • {"month"=>"8", "year"=>"2015", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"20"}
  • {"month"=>"9", "year"=>"2015", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"17"}
  • {"month"=>"10", "year"=>"2015", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"28"}
  • {"month"=>"11", "year"=>"2015", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"27"}
  • {"month"=>"12", "year"=>"2015", "pdf_views"=>"0", "xml_views"=>"0", "html_views"=>"16"}
  • {"month"=>"1", "year"=>"2016", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"16"}
  • {"month"=>"2", "year"=>"2016", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"12"}
  • {"month"=>"3", "year"=>"2016", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"26"}
  • {"month"=>"4", "year"=>"2016", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"18"}
  • {"month"=>"5", "year"=>"2016", "pdf_views"=>"0", "xml_views"=>"0", "html_views"=>"10"}
  • {"month"=>"6", "year"=>"2016", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"8"}
  • {"month"=>"7", "year"=>"2016", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"12"}
  • {"month"=>"8", "year"=>"2016", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"22"}
  • {"month"=>"9", "year"=>"2016", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"24"}
  • {"month"=>"10", "year"=>"2016", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"24"}
  • {"month"=>"11", "year"=>"2016", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"17"}
  • {"month"=>"12", "year"=>"2016", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"11"}
  • {"month"=>"1", "year"=>"2017", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"77"}
  • {"month"=>"2", "year"=>"2017", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"149"}
  • {"month"=>"3", "year"=>"2017", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"165"}
  • {"month"=>"4", "year"=>"2017", "pdf_views"=>"2", "xml_views"=>"1", "html_views"=>"176"}
  • {"month"=>"5", "year"=>"2017", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"168"}
  • {"month"=>"6", "year"=>"2017", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"192"}
  • {"month"=>"7", "year"=>"2017", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"173"}
  • {"month"=>"8", "year"=>"2017", "pdf_views"=>"3", "xml_views"=>"2", "html_views"=>"192"}
  • {"month"=>"9", "year"=>"2017", "pdf_views"=>"4", "xml_views"=>"1", "html_views"=>"168"}
  • {"month"=>"10", "year"=>"2017", "pdf_views"=>"7", "xml_views"=>"1", "html_views"=>"150"}
  • {"month"=>"11", "year"=>"2017", "pdf_views"=>"0", "xml_views"=>"0", "html_views"=>"163"}
  • {"month"=>"12", "year"=>"2017", "pdf_views"=>"7", "xml_views"=>"1", "html_views"=>"148"}
  • {"month"=>"1", "year"=>"2018", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"44"}
  • {"month"=>"2", "year"=>"2018", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"5"}
  • {"month"=>"3", "year"=>"2018", "pdf_views"=>"0", "xml_views"=>"0", "html_views"=>"3"}
  • {"month"=>"4", "year"=>"2018", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"7"}
  • {"month"=>"5", "year"=>"2018", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"6"}
  • {"month"=>"6", "year"=>"2018", "pdf_views"=>"0", "xml_views"=>"0", "html_views"=>"3"}
  • {"month"=>"7", "year"=>"2018", "pdf_views"=>"4", "xml_views"=>"3", "html_views"=>"3"}
  • {"month"=>"8", "year"=>"2018", "pdf_views"=>"0", "xml_views"=>"2", "html_views"=>"3"}
  • {"month"=>"9", "year"=>"2018", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"10"}
  • {"month"=>"10", "year"=>"2018", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"5"}
  • {"month"=>"11", "year"=>"2018", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"9"}
  • {"month"=>"12", "year"=>"2018", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"4"}
  • {"month"=>"1", "year"=>"2019", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"2"}
  • {"month"=>"2", "year"=>"2019", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"9"}
  • {"month"=>"3", "year"=>"2019", "pdf_views"=>"7", "xml_views"=>"1", "html_views"=>"2"}
  • {"month"=>"4", "year"=>"2019", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"3"}
  • {"month"=>"5", "year"=>"2019", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"1"}
  • {"month"=>"6", "year"=>"2019", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"2"}
  • {"month"=>"7", "year"=>"2019", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"1"}
  • {"month"=>"8", "year"=>"2019", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"3"}
  • {"month"=>"9", "year"=>"2019", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"2"}
  • {"month"=>"10", "year"=>"2019", "pdf_views"=>"0", "xml_views"=>"0", "html_views"=>"2"}
  • {"month"=>"11", "year"=>"2019", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"2"}
  • {"month"=>"12", "year"=>"2019", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"5"}
  • {"month"=>"1", "year"=>"2020", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"6"}
  • {"month"=>"2", "year"=>"2020", "pdf_views"=>"9", "xml_views"=>"1", "html_views"=>"6"}
  • {"month"=>"3", "year"=>"2020", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"3"}
  • {"month"=>"4", "year"=>"2020", "pdf_views"=>"13", "xml_views"=>"1", "html_views"=>"2"}
  • {"month"=>"5", "year"=>"2020", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"3"}
  • {"month"=>"6", "year"=>"2020", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"2"}
  • {"month"=>"7", "year"=>"2020", "pdf_views"=>"0", "xml_views"=>"0", "html_views"=>"3"}
  • {"month"=>"8", "year"=>"2020", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"4"}
  • {"month"=>"9", "year"=>"2020", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"0"}
  • {"month"=>"10", "year"=>"2020", "pdf_views"=>"2", "xml_views"=>"1", "html_views"=>"2"}
  • {"month"=>"11", "year"=>"2020", "pdf_views"=>"3", "xml_views"=>"1", "html_views"=>"9"}
  • {"month"=>"12", "year"=>"2020", "pdf_views"=>"6", "xml_views"=>"1", "html_views"=>"3"}
  • {"month"=>"1", "year"=>"2021", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"2"}
  • {"month"=>"2", "year"=>"2021", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"3"}

Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/520226"], "description"=>"<p>Indel polymorphism/SNP rs numbers from reference sequences of <i>p63</i> GenBank (Locus: NC_000003). Sumitter SNP (ss) accession numbers from NCBI. Data were sourced from 108 Caucasian patients, 126 Caucasian controls, 55 Non-Caucasian patients and 159 Non-Caucasian controls.</p>*<p>Heterozygous Novel SNP ss#541026548 (Ch. 3 position 190987627) was associated with a decreased risk of BEEC (p = 0.0071, OR = 2.357, CI 95% = 1.256–4.426).</p>**<p>Heterozygous SNP rs1464117 (Ch. 3 position 190989223) was associated with a decreased risk of BEEC (p = 0.0379, OR = 2.164, CI 95% = 1.035–4.527). Data were analyzed with contingency tables, χ-square, odds ratio and 95% confidence intervals.</p>", "links"=>[], "tags"=>["nucleotide", "polymorphisms", "promoter", "beec", "patients"], "article_id"=>190693, "categories"=>["Genetics"], "users"=>["Simon Wilkins", "Ke Wei Zhang", "Istiak Mahfuz", "Renaud Quantin", "Nancy D'Cruz", "John Hutson", "Michael Ee", "Darius Bagli", "Karen Aitken", "Fion Nga-Yin Fong", "Patrick Kwok-Shing Ng", "Stephen Kwok-Wing Tsui", "Wendy Yin-Wan Fung", "Tahmina Banu", "Atul Thakre", "Kaid Johar", "Enrique Jaureguizar", "Long Li", "Wei Cheng"], "doi"=>"https://dx.doi.org/10.1371/journal.pgen.1003070.t002", "stats"=>{"downloads"=>3, "page_views"=>15, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Single_nucleotide_polymorphisms_and_insertion_deletion_polymorphisms_in_i_Np63_i_promoter_found_in_BEEC_patients_and_normal_controls_/190693", "title"=>"Single nucleotide polymorphisms and insertion/deletion polymorphisms in <i>ΔNp63</i> promoter found in BEEC patients and normal controls.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-19 18:14:08"}
  • {"files"=>["https://ndownloader.figshare.com/files/519920"], "description"=>"<p>Frequencies for each genotype are shown in <a href=\"http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1003070#pgen-1003070-t005\" target=\"_blank\">Table 5</a>. P: p-value. OR: odds ratio CI: 95% confidence intervals. Del: deletion. Ins: insertion. bp: base pair. Data were analyzed with contingency tables, χ-square, odds ratio and 95% confidence intervals.</p>", "links"=>[], "tags"=>["beec", "groups", "ethnically-matched"], "article_id"=>190382, "categories"=>["Genetics"], "users"=>["Simon Wilkins", "Ke Wei Zhang", "Istiak Mahfuz", "Renaud Quantin", "Nancy D'Cruz", "John Hutson", "Michael Ee", "Darius Bagli", "Karen Aitken", "Fion Nga-Yin Fong", "Patrick Kwok-Shing Ng", "Stephen Kwok-Wing Tsui", "Wendy Yin-Wan Fung", "Tahmina Banu", "Atul Thakre", "Kaid Johar", "Enrique Jaureguizar", "Long Li", "Wei Cheng"], "doi"=>"https://dx.doi.org/10.1371/journal.pgen.1003070.t004", "stats"=>{"downloads"=>1, "page_views"=>20, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Comparison_of_each_of_the_BEEC_patient_groups_against_the_ethnically_matched_controls_/190382", "title"=>"Comparison of each of the BEEC patient groups against the ethnically-matched controls.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-19 18:12:18"}
  • {"files"=>["https://ndownloader.figshare.com/files/520107"], "description"=>"<p>Genotypes of BEEC patient samples used in real-time expression experiments.</p>", "links"=>[], "tags"=>["beec", "samples", "Real-time"], "article_id"=>190570, "categories"=>["Genetics"], "users"=>["Simon Wilkins", "Ke Wei Zhang", "Istiak Mahfuz", "Renaud Quantin", "Nancy D'Cruz", "John Hutson", "Michael Ee", "Darius Bagli", "Karen Aitken", "Fion Nga-Yin Fong", "Patrick Kwok-Shing Ng", "Stephen Kwok-Wing Tsui", "Wendy Yin-Wan Fung", "Tahmina Banu", "Atul Thakre", "Kaid Johar", "Enrique Jaureguizar", "Long Li", "Wei Cheng"], "doi"=>"https://dx.doi.org/10.1371/journal.pgen.1003070.t001", "stats"=>{"downloads"=>1, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Genotypes_of_BEEC_patient_samples_used_in_real_time_expression_experiments_/190570", "title"=>"Genotypes of BEEC patient samples used in real-time expression experiments.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-19 18:13:30"}
  • {"files"=>["https://ndownloader.figshare.com/files/519722"], "description"=>"<p>Luciferase assay of <i>ΔNp63</i> promoters with various indel polymorphisms transfected into human embryonic kidney (HEK-293) cells. Normal Control sequence (con), 12 base pair deletion (12 bp; rs6148242), 1 base pair insertion (1 bp, rs5855273), 4 base pair insertion (4 bp, ss#541028600). Data shown is the average of 8 experiments, each examined in triplicate. Data +/− SEM, * : p&lt;0.05, ** p&lt;0.01, *** : p&lt;0.001, compared to normal control, One-way ANOVA, Bonferroni's Multiple Comparison test.</p>", "links"=>[], "tags"=>["polymorphisms", "transcriptional"], "article_id"=>190188, "categories"=>["Genetics"], "users"=>["Simon Wilkins", "Ke Wei Zhang", "Istiak Mahfuz", "Renaud Quantin", "Nancy D'Cruz", "John Hutson", "Michael Ee", "Darius Bagli", "Karen Aitken", "Fion Nga-Yin Fong", "Patrick Kwok-Shing Ng", "Stephen Kwok-Wing Tsui", "Wendy Yin-Wan Fung", "Tahmina Banu", "Atul Thakre", "Kaid Johar", "Enrique Jaureguizar", "Long Li", "Wei Cheng"], "doi"=>"https://dx.doi.org/10.1371/journal.pgen.1003070.g003", "stats"=>{"downloads"=>0, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Indel_polymorphisms_decrease_transcriptional_efficiency_/190188", "title"=>"Indel polymorphisms decrease transcriptional efficiency.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-19 18:11:16"}
  • {"files"=>["https://ndownloader.figshare.com/files/520168"], "description"=>"<p>Data were sourced from 108 Caucasian patients, 126 Caucasian controls, 55 Non-Caucasian patients and 159 Non-Caucasian controls. Actual numbers for each genotype are shown in <a href=\"http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1003070#pgen-1003070-t002\" target=\"_blank\">Table 2</a>. P: p-value. OR: odds ratio CI: 95% confidence intervals. Del: deletion. Ins: insertion. bp: base pair. Data were analyzed with contingency tables, χ-square, odds ratio and 95% confidence intervals.</p>", "links"=>[], "tags"=>["genotype", "frequencies", "beec", "patients"], "article_id"=>190638, "categories"=>["Genetics"], "users"=>["Simon Wilkins", "Ke Wei Zhang", "Istiak Mahfuz", "Renaud Quantin", "Nancy D'Cruz", "John Hutson", "Michael Ee", "Darius Bagli", "Karen Aitken", "Fion Nga-Yin Fong", "Patrick Kwok-Shing Ng", "Stephen Kwok-Wing Tsui", "Wendy Yin-Wan Fung", "Tahmina Banu", "Atul Thakre", "Kaid Johar", "Enrique Jaureguizar", "Long Li", "Wei Cheng"], "doi"=>"https://dx.doi.org/10.1371/journal.pgen.1003070.t003", "stats"=>{"downloads"=>1, "page_views"=>13, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Comparison_of_genotype_frequencies_between_BEEC_patients_and_normal_controls_/190638", "title"=>"Comparison of genotype frequencies between BEEC patients and normal controls.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-19 18:13:49"}
  • {"files"=>["https://ndownloader.figshare.com/files/520054"], "description"=>"<p>Cauc: Caucasian patient sequence. Non-Cauc: Non Caucasian patient sequence. Bp: base pair.</p>", "links"=>[], "tags"=>["beec", "patients", "controls", "sub-cloned", "pgl3", "luciferase"], "article_id"=>190511, "categories"=>["Genetics"], "users"=>["Simon Wilkins", "Ke Wei Zhang", "Istiak Mahfuz", "Renaud Quantin", "Nancy D'Cruz", "John Hutson", "Michael Ee", "Darius Bagli", "Karen Aitken", "Fion Nga-Yin Fong", "Patrick Kwok-Shing Ng", "Stephen Kwok-Wing Tsui", "Wendy Yin-Wan Fung", "Tahmina Banu", "Atul Thakre", "Kaid Johar", "Enrique Jaureguizar", "Long Li", "Wei Cheng"], "doi"=>"https://dx.doi.org/10.1371/journal.pgen.1003070.t006", "stats"=>{"downloads"=>6, "page_views"=>16, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Sequences_of_BEEC_patients_and_controls_sub_cloned_into_the_pGL3_luciferase_vector_/190511", "title"=>"Sequences of BEEC patients and controls sub-cloned into the pGL3 luciferase vector.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-19 18:13:09"}
  • {"files"=>["https://ndownloader.figshare.com/files/519857"], "description"=>"<p>Data were sourced from 77 Caucasian patients, 94 Caucasian controls, 41 Non-Caucasian patients and 44 Non-Caucasian controls. Del: deletion. Ins: insertion. bp: base pair.</p>", "links"=>[], "tags"=>["indel", "genotypes", "caucasian", "non-caucasian"], "article_id"=>190318, "categories"=>["Genetics"], "users"=>["Simon Wilkins", "Ke Wei Zhang", "Istiak Mahfuz", "Renaud Quantin", "Nancy D'Cruz", "John Hutson", "Michael Ee", "Darius Bagli", "Karen Aitken", "Fion Nga-Yin Fong", "Patrick Kwok-Shing Ng", "Stephen Kwok-Wing Tsui", "Wendy Yin-Wan Fung", "Tahmina Banu", "Atul Thakre", "Kaid Johar", "Enrique Jaureguizar", "Long Li", "Wei Cheng"], "doi"=>"https://dx.doi.org/10.1371/journal.pgen.1003070.t005", "stats"=>{"downloads"=>1, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Frequency_of_indel_genotypes_in_Caucasian_and_non_Caucasian_groups_/190318", "title"=>"Frequency (%) of indel genotypes in Caucasian and non-Caucasian groups.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-19 18:11:58"}
  • {"files"=>["https://ndownloader.figshare.com/files/519460"], "description"=>"<p>(A) Real-time qPCR of <i>ΔNp63</i> (white column) and <i>TAp63</i> (black column) expression dorsal and ventral foreskin from normal control (2 yr. male). (B) Real time qPCR of <i>ΔNp63</i> expression dorsal (black hatched column) and ventral foreskin (black column) from 2 normal controls and dorsal (hatched column) and ventral foreskin (white column) from a BEEC patient. (C) Real-time qPCR of <i>ΔNp63</i> expression in from BEEC patient (8 yr. male) dorsal (black column) and ventral (white column) foreskin mucosa and skin. (D) Real-time qPCR showing reduced <i>ΔNp63</i> mRNA expression in BEEC bladder epithelium compared with 2 normal controls. (E) Increased <i>TAp63</i> mRNA expression in BEEC bladder epithelium compared with 2 normal controls. (F) Real-time qPCR showing reduced <i>ΔNp63</i> mRNA and increased <i>TAp63</i> mRNA expression in bladder mucosa from a Caucasian BEEC patient (&lt;1 yr. male) compared with normal controls (normalized to 1). (G) Real-time qPCR showing <i>ΔNp63</i> and <i>TAp63</i> mRNA expression in bladder mucosa from a three Caucasian BEEC patients (A, 13 yr. male; B, 14 yr. female; C, 6 yr. male) compared with normal controls (normalized to 1).</p>", "links"=>[], "tags"=>["isoforms", "beec"], "article_id"=>189910, "categories"=>["Genetics"], "users"=>["Simon Wilkins", "Ke Wei Zhang", "Istiak Mahfuz", "Renaud Quantin", "Nancy D'Cruz", "John Hutson", "Michael Ee", "Darius Bagli", "Karen Aitken", "Fion Nga-Yin Fong", "Patrick Kwok-Shing Ng", "Stephen Kwok-Wing Tsui", "Wendy Yin-Wan Fung", "Tahmina Banu", "Atul Thakre", "Kaid Johar", "Enrique Jaureguizar", "Long Li", "Wei Cheng"], "doi"=>"https://dx.doi.org/10.1371/journal.pgen.1003070.g001", "stats"=>{"downloads"=>2, "page_views"=>15, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Expression_of_i_p63_i_isoforms_in_BEEC_patient_tissue_and_controls_/189910", "title"=>"Expression of <i>p63</i> isoforms in BEEC patient tissue and controls.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-19 18:09:36"}
  • {"files"=>["https://ndownloader.figshare.com/files/519983"], "description"=>"<p>P: p-value. CI: 95% confidence intervals. Bp: base pair. Ins: insertion, Del: deletion. Data compared to normal control, One-way ANOVA, Bonferroni's Multiple Comparison test.</p>", "links"=>[], "tags"=>["transcriptional", "efficiencies", "indel", "polymorphic", "promoters", "compared"], "article_id"=>190457, "categories"=>["Genetics"], "users"=>["Simon Wilkins", "Ke Wei Zhang", "Istiak Mahfuz", "Renaud Quantin", "Nancy D'Cruz", "John Hutson", "Michael Ee", "Darius Bagli", "Karen Aitken", "Fion Nga-Yin Fong", "Patrick Kwok-Shing Ng", "Stephen Kwok-Wing Tsui", "Wendy Yin-Wan Fung", "Tahmina Banu", "Atul Thakre", "Kaid Johar", "Enrique Jaureguizar", "Long Li", "Wei Cheng"], "doi"=>"https://dx.doi.org/10.1371/journal.pgen.1003070.t007", "stats"=>{"downloads"=>1, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Statistical_significance_of_reduction_of_transcriptional_efficiencies_of_indel_polymorphic_i_Np63_i_promoters_compared_to_normal_controls_/190457", "title"=>"Statistical significance of reduction of transcriptional efficiencies of indel polymorphic <i>ΔNp63</i> promoters compared to normal controls.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-19 18:12:48"}
  • {"files"=>["https://ndownloader.figshare.com/files/519590"], "description"=>"<p>The height of the bars represents the Odds Ratio (OR). Promoter positions of SNPs and indel that are not associated with any significant change in risk of BEEC are shown in black. OR represented: 12 bp heterozygous (het) all patients (grey; OR = 1.763); 12 bp homozygous (hom) all patients (red; OR = 10.80); 1 bp hom all patients (red; OR = 8.794); 4 bp hom all patients (red; OR = 2.722); 12 bp het Caucasian patients (brown; OR = 2.357); 12 bp hom Caucasian patients (green; OR = 18.33); 1 bp hom Caucasian patients (green; OR = 44.10); 1 bp hom Non-Caucasian patients (purple; OR = 4.513); 4 bp hom Non-Caucasians patients (purple; OR = 4.583). Two SNPs associated with decreased risk of BEEC are shown in blue: SNP −1059 (OR = 2.164); SNP −2657 (OR = 3.060).</p>", "links"=>[], "tags"=>["promoter", "snp", "indel"], "article_id"=>190063, "categories"=>["Genetics"], "users"=>["Simon Wilkins", "Ke Wei Zhang", "Istiak Mahfuz", "Renaud Quantin", "Nancy D'Cruz", "John Hutson", "Michael Ee", "Darius Bagli", "Karen Aitken", "Fion Nga-Yin Fong", "Patrick Kwok-Shing Ng", "Stephen Kwok-Wing Tsui", "Wendy Yin-Wan Fung", "Tahmina Banu", "Atul Thakre", "Kaid Johar", "Enrique Jaureguizar", "Long Li", "Wei Cheng"], "doi"=>"https://dx.doi.org/10.1371/journal.pgen.1003070.g002", "stats"=>{"downloads"=>0, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Schematic_representation_of_the_human_i_Np63_i_promoter_showing_SNP_and_indel_locations_/190063", "title"=>"Schematic representation of the human <i>ΔNp63</i> promoter showing SNP and indel locations.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-19 18:10:30"}
  • {"files"=>["https://ndownloader.figshare.com/files/519782"], "description"=>"<p>The associated anomalies of BEEC patients compared with the <i>p63<sup>−/−</sup></i> mouse phenotype.</p>", "links"=>[], "tags"=>["anomalies", "beec", "patients", "compared"], "article_id"=>190261, "categories"=>["Genetics"], "users"=>["Simon Wilkins", "Ke Wei Zhang", "Istiak Mahfuz", "Renaud Quantin", "Nancy D'Cruz", "John Hutson", "Michael Ee", "Darius Bagli", "Karen Aitken", "Fion Nga-Yin Fong", "Patrick Kwok-Shing Ng", "Stephen Kwok-Wing Tsui", "Wendy Yin-Wan Fung", "Tahmina Banu", "Atul Thakre", "Kaid Johar", "Enrique Jaureguizar", "Long Li", "Wei Cheng"], "doi"=>"https://dx.doi.org/10.1371/journal.pgen.1003070.t008", "stats"=>{"downloads"=>4, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/The_associated_anomalies_of_BEEC_patients_compared_with_the_i_p63_sup__sup_i_mouse_phenotype_/190261", "title"=>"The associated anomalies of BEEC patients compared with the <i>p63<sup>−/−</sup></i> mouse phenotype.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-19 18:11:39"}

PMC Usage Stats | Further Information

  • {"unique-ip"=>"2", "full-text"=>"2", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"8"}
  • {"unique-ip"=>"5", "full-text"=>"5", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"9"}
  • {"unique-ip"=>"3", "full-text"=>"2", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"10"}
  • {"unique-ip"=>"5", "full-text"=>"3", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"11"}
  • {"unique-ip"=>"8", "full-text"=>"9", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"12"}
  • {"unique-ip"=>"11", "full-text"=>"2", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"1"}
  • {"unique-ip"=>"3", "full-text"=>"1", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"2"}
  • {"unique-ip"=>"6", "full-text"=>"5", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"3"}
  • {"unique-ip"=>"2", "full-text"=>"1", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"4"}
  • {"unique-ip"=>"3", "full-text"=>"4", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"5"}
  • {"unique-ip"=>"2", "full-text"=>"2", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"6"}
  • {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"7"}
  • {"unique-ip"=>"6", "full-text"=>"8", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"8"}
  • {"unique-ip"=>"3", "full-text"=>"3", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"9"}
  • {"unique-ip"=>"3", "full-text"=>"2", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"10"}
  • {"unique-ip"=>"2", "full-text"=>"2", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"11"}
  • {"unique-ip"=>"3", "full-text"=>"2", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"12"}
  • {"unique-ip"=>"1", "full-text"=>"1", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"1"}
  • {"unique-ip"=>"5", "full-text"=>"4", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"3"}
  • {"unique-ip"=>"7", "full-text"=>"8", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"1"}
  • {"unique-ip"=>"5", "full-text"=>"8", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"4"}
  • {"unique-ip"=>"1", "full-text"=>"2", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"5"}
  • {"unique-ip"=>"3", "full-text"=>"2", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"6"}
  • {"unique-ip"=>"6", "full-text"=>"3", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"7"}
  • {"unique-ip"=>"7", "full-text"=>"7", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"8"}
  • {"unique-ip"=>"7", "full-text"=>"7", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"10"}
  • {"unique-ip"=>"3", "full-text"=>"2", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"9"}
  • {"unique-ip"=>"10", "full-text"=>"8", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"11"}
  • {"unique-ip"=>"6", "full-text"=>"7", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"12"}
  • {"unique-ip"=>"11", "full-text"=>"13", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"2"}
  • {"unique-ip"=>"2", "full-text"=>"2", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"3"}
  • {"unique-ip"=>"6", "full-text"=>"5", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"4"}
  • {"unique-ip"=>"6", "full-text"=>"8", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"5"}
  • {"unique-ip"=>"5", "full-text"=>"5", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"8"}
  • {"unique-ip"=>"6", "full-text"=>"4", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"9"}
  • {"unique-ip"=>"7", "full-text"=>"6", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"10"}
  • {"unique-ip"=>"6", "full-text"=>"3", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"12"}
  • {"unique-ip"=>"6", "full-text"=>"5", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"2"}
  • {"unique-ip"=>"8", "full-text"=>"8", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"3"}
  • {"unique-ip"=>"8", "full-text"=>"8", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"4"}
  • {"unique-ip"=>"4", "full-text"=>"5", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"5"}
  • {"unique-ip"=>"4", "full-text"=>"3", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"6"}
  • {"unique-ip"=>"2", "full-text"=>"2", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"7"}
  • {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"8"}
  • {"unique-ip"=>"2", "full-text"=>"2", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"9"}
  • {"unique-ip"=>"5", "full-text"=>"1", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"10"}
  • {"unique-ip"=>"4", "full-text"=>"3", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"11"}
  • {"unique-ip"=>"5", "full-text"=>"4", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"12"}
  • {"unique-ip"=>"5", "full-text"=>"2", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2021", "month"=>"1"}

Relative Metric

{"start_date"=>"2012-01-01T00:00:00Z", "end_date"=>"2012-12-31T00:00:00Z", "subject_areas"=>[{"subject_area"=>"/Biology and life sciences/Anatomy", "average_usage"=>[308, 530, 649, 751, 844, 933, 1021, 1107, 1194, 1277, 1357, 1426, 1501, 1572, 1634, 1702, 1768, 1838, 1910, 1976, 2046, 2114, 2181, 2241, 2298]}, {"subject_area"=>"/Biology and life sciences/Anatomy and physiology", "average_usage"=>[307, 540, 660, 756, 847, 936, 1025, 1111, 1199, 1282, 1361, 1432]}, {"subject_area"=>"/Medicine and health sciences/Anatomy", "average_usage"=>[307, 529, 649, 751, 845, 936, 1025, 1113, 1197, 1284, 1360, 1432, 1501, 1570, 1632, 1697, 1765, 1834, 1904, 1972, 2041, 2107, 2170, 2231, 2292]}]}
Loading … Spinner
There are currently no alerts