Genetic and Anatomical Basis of the Barrier Separating Wakefulness and Anesthetic-Induced Unresponsiveness
Publication Date
September 05, 2013
Journal
PLOS Genetics
Authors
William J. Joiner, Eliot B. Friedman, Hsiao Tung Hung, Kyunghee Koh, et al
Volume
9
Issue
9
Pages
e1003605
DOI
https://dx.plos.org/10.1371/journal.pgen.1003605
Publisher URL
http://journals.plos.org/plosgenetics/article?id=10.1371%2Fjournal.pgen.1003605
Scopus
84884683543
Mendeley
http://www.mendeley.com/research/genetic-anatomical-basis-barrier-separating-wakefulness-anestheticinduced-unresponsiveness
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Mendeley | Further Information

{"title"=>"Genetic and Anatomical Basis of the Barrier Separating Wakefulness and Anesthetic-Induced Unresponsiveness", "type"=>"journal", "authors"=>[{"first_name"=>"William J.", "last_name"=>"Joiner", "scopus_author_id"=>"6701543231"}, {"first_name"=>"Eliot B.", "last_name"=>"Friedman", "scopus_author_id"=>"34869390600"}, {"first_name"=>"Hsiao Tung", "last_name"=>"Hung", "scopus_author_id"=>"36608200700"}, {"first_name"=>"Kyunghee", "last_name"=>"Koh", "scopus_author_id"=>"14025798500"}, {"first_name"=>"Mallory", "last_name"=>"Sowcik", "scopus_author_id"=>"34769034500"}, {"first_name"=>"Amita", "last_name"=>"Sehgal", "scopus_author_id"=>"7102296049"}, {"first_name"=>"Max B.", "last_name"=>"Kelz", "scopus_author_id"=>"6602185403"}], "year"=>2013, "source"=>"PLoS Genetics", "identifiers"=>{"doi"=>"10.1371/journal.pgen.1003605", "scopus"=>"2-s2.0-84884683543", "pui"=>"369904004", "issn"=>"15537390", "pmid"=>"24039590", "sgr"=>"84884683543", "isbn"=>"1553-7404 (Electronic)\\r1553-7390 (Linking)"}, "id"=>"657ad2df-fd17-3b56-84e3-edee02fdb21c", "abstract"=>"A robust, bistable switch regulates the fluctuations between wakefulness and natural sleep as well as those between wakefulness and anesthetic-induced unresponsiveness. We previously provided experimental evidence for the existence of a behavioral barrier to transitions between these states of arousal, which we call neural inertia. Here we show that neural inertia is controlled by processes that contribute to sleep homeostasis and requires four genes involved in electrical excitability: Sh, sss, na and unc79. Although loss of function mutations in these genes can increase or decrease sensitivity to anesthesia induction, surprisingly, they all collapse neural inertia. These effects are genetically selective: neural inertia is not perturbed by loss-of-function mutations in all genes required for the sleep/wake cycle. These effects are also anatomically selective: sss acts in different neurons to influence arousal-promoting and arousal-suppressing processes underlying neural inertia. Supporting the idea that anesthesia and sleep share some, but not all, genetic and anatomical arousal-regulating pathways, we demonstrate that increasing homeostatic sleep drive widens the neural inertial barrier. We propose that processes selectively contributing to sleep homeostasis and neural inertia may be impaired in pathophysiological conditions such as coma and persistent vegetative states.", "link"=>"http://www.mendeley.com/research/genetic-anatomical-basis-barrier-separating-wakefulness-anestheticinduced-unresponsiveness", "reader_count"=>57, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Professor > Associate Professor"=>4, "Researcher"=>10, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>16, "Student > Postgraduate"=>2, "Student > Master"=>6, "Other"=>5, "Student > Bachelor"=>6, "Lecturer"=>1, "Lecturer > Senior Lecturer"=>1, "Professor"=>3}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Professor > Associate Professor"=>4, "Researcher"=>10, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>16, "Student > Postgraduate"=>2, "Student > Master"=>6, "Other"=>5, "Student > Bachelor"=>6, "Lecturer"=>1, "Lecturer > Senior Lecturer"=>1, "Professor"=>3}, "reader_count_by_subject_area"=>{"Engineering"=>3, "Unspecified"=>1, "Biochemistry, Genetics and Molecular Biology"=>3, "Agricultural and Biological Sciences"=>18, "Medicine and Dentistry"=>12, "Neuroscience"=>11, "Physics and Astronomy"=>5, "Psychology"=>3, "Chemistry"=>1}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>3}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>12}, "Neuroscience"=>{"Neuroscience"=>11}, "Chemistry"=>{"Chemistry"=>1}, "Physics and Astronomy"=>{"Physics and Astronomy"=>5}, "Psychology"=>{"Psychology"=>3}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>18}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>3}, "Unspecified"=>{"Unspecified"=>1}}, "reader_count_by_country"=>{"South Korea"=>1, "Japan"=>1, "China"=>1, "Portugal"=>1, "Spain"=>1}, "group_count"=>5}

Scopus | Further Information

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