Telomere Shortening Unrelated to Smoking, Body Weight, Physical Activity, and Alcohol Intake: 4,576 General Population Individuals with Repeat Measurements 10 Years Apart
- Publication Date
- March 13, 2014
- Journal
- PLOS Genetics
- Authors
- Maren Weischer, Stig E. Bojesen & Børge G. Nordestgaard
- Volume
- 10
- Issue
- 3
- Pages
- e1004191
- DOI
- https://dx.plos.org/10.1371/journal.pgen.1004191
- Publisher URL
- http://journals.plos.org/plosgenetics/article?id=10.1371%2Fjournal.pgen.1004191
- PubMed
- http://www.ncbi.nlm.nih.gov/pubmed/24625632
- PubMed Central
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3953026
- Europe PMC
- http://europepmc.org/abstract/MED/24625632
- Web of Science
- 000337144700023
- Scopus
- 84897397399
- Mendeley
- http://www.mendeley.com/research/telomere-shortening-unrelated-smoking-body-weight-physical-activity-alcohol-intake-4576-general-popu
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Mendeley | Further Information
{"title"=>"Telomere Shortening Unrelated to Smoking, Body Weight, Physical Activity, and Alcohol Intake: 4,576 General Population Individuals with Repeat Measurements 10 Years Apart", "type"=>"journal", "authors"=>[{"first_name"=>"Maren", "last_name"=>"Weischer", "scopus_author_id"=>"23500334000"}, {"first_name"=>"Stig E.", "last_name"=>"Bojesen", "scopus_author_id"=>"6506527936"}, {"first_name"=>"Børge G.", "last_name"=>"Nordestgaard", "scopus_author_id"=>"7007170557"}], "year"=>2014, "source"=>"PLoS Genetics", "identifiers"=>{"issn"=>"15537404", "isbn"=>"1553-7390", "pui"=>"372738213", "sgr"=>"84897397399", "doi"=>"10.1371/journal.pgen.1004191", "scopus"=>"2-s2.0-84897397399", "pmid"=>"24625632"}, "id"=>"8455ea25-a6b5-3c26-a378-731bef494001", "abstract"=>"Cross-sectional studies have associated short telomere length with smoking, body weight, physical activity, and possibly alcohol intake; however, whether these associations are due to confounding is unknown. We tested these hypotheses in 4,576 individuals from the general population cross-sectionally, and with repeat measurement of relative telomere length 10 years apart. We also tested whether change in telomere length is associated with mortality and morbidity in the general population. Relative telomere length was measured with quantitative polymerase chain reaction. Cross-sectionally at the first examination, short telomere length was associated with increased age (P for trend across quartiles = 3x10-77), current smoking (P = 8x10-3), increased body mass index (P = 7x10-14), physical inactivity (P = 4x10-17), but not with increased alcohol intake (P = 0.10). At the second examination 10 years later, 56% of participants had lost and 44% gained telomere length with a mean loss of 193 basepairs. Change in leukocyte telomere length during 10 years was associated inversely with baseline telomere length (P<1x10-300) and age at baseline (P = 1x10-27), but not with baseline or 10-year inter-observational tobacco consumption, body weight, physical activity, or alcohol intake. Prospectively during a further 10 years follow-up after the second examination, quartiles of telomere length change did not associate with risk of all-cause mortality, cancer, chronic obstructive pulmonary disease, diabetes mellitus, ischemic cerebrovascular disease, or ischemic heart disease. In conclusion, smoking, increased body weight, and physical inactivity were associated with short telomere length cross-sectionally, but not with telomere length change during 10 years observation, and alcohol intake was associated with neither. Also, change in telomere length did not associate prospectively with mortality or morbidity in the general population", "link"=>"http://www.mendeley.com/research/telomere-shortening-unrelated-smoking-body-weight-physical-activity-alcohol-intake-4576-general-popu", "reader_count"=>64, "reader_count_by_academic_status"=>{"Unspecified"=>2, "Professor > Associate Professor"=>2, "Librarian"=>2, "Researcher"=>14, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>20, "Student > Postgraduate"=>2, "Other"=>2, "Student > Master"=>6, "Student > Bachelor"=>8, "Lecturer"=>1, "Professor"=>3}, "reader_count_by_user_role"=>{"Unspecified"=>2, "Professor > Associate Professor"=>2, "Librarian"=>2, "Researcher"=>14, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>20, "Student > Postgraduate"=>2, "Other"=>2, "Student > Master"=>6, "Student > Bachelor"=>8, "Lecturer"=>1, "Professor"=>3}, "reader_count_by_subject_area"=>{"Unspecified"=>5, "Environmental Science"=>1, "Biochemistry, Genetics and Molecular Biology"=>7, "Nursing and Health Professions"=>1, "Medicine and Dentistry"=>22, "Agricultural and Biological Sciences"=>16, "Sports and Recreations"=>2, "Pharmacology, Toxicology and Pharmaceutical Science"=>1, "Psychology"=>4, "Social Sciences"=>3, "Computer Science"=>1, "Immunology and Microbiology"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>22}, "Social Sciences"=>{"Social Sciences"=>3}, "Sports and Recreations"=>{"Sports and Recreations"=>2}, "Psychology"=>{"Psychology"=>4}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>16}, "Computer Science"=>{"Computer Science"=>1}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>7}, "Unspecified"=>{"Unspecified"=>5}, "Environmental Science"=>{"Environmental Science"=>1}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>1}}, "reader_count_by_country"=>{"Turkey"=>1, "Korea (South)"=>1, "United States"=>1, "Brazil"=>2, "Portugal"=>1, "Russia"=>1}, "group_count"=>1}CrossRef
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Scopus | Further Information
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- {"id"=>"445342659352469504", "text"=>"@SandraPhD @felipevaca. Interesante trabajo. Quiero otro reporte en 10 años. Interesante datos de cáncer, na de na. http://t.co/iHKYsQeNOy", "created_at"=>"2014-03-16T23:35:38Z", "user"=>"javiom", "user_name"=>"Javier Oliver", "user_profile_image"=>"http://pbs.twimg.com/profile_images/3371790567/713668f0a7c2137c692e275ada817903_normal.jpeg"}
- {"id"=>"445356481148620800", "text"=>"RT @DrKhouryCDC: RT @drbachinsky Telomere shortening-no relation to smoking' weight, physical activity & death @PLOSGenetics http://t.co/VZ…", "created_at"=>"2014-03-17T00:30:34Z", "user"=>"doctorfullerton", "user_name"=>"Merrilee Fullerton", "user_profile_image"=>"http://pbs.twimg.com/profile_images/378800000467722246/c96eb53c48001a8c55ff02bc1780d5ab_normal.jpeg"}
- {"id"=>"445356732735176704", "text"=>"横断研究ならテロメアの長さと喫煙やBMI、運動と相関するけど、縦断研究(10年)なら相関しない。癌などとの関連もない。Telomere Shortening Unrelated to Smoking, Body Weight, … http://t.co/tU4GIgVXBt", "created_at"=>"2014-03-17T00:31:34Z", "user"=>"uranus_2", "user_name"=>"マーキュリー2世", "user_profile_image"=>"http://abs.twimg.com/sticky/default_profile_images/default_profile_5_normal.png"}
- {"id"=>"448685442246774785", "text"=>"Telomere Shortening Unrelated to Smoking, Body Weight, Physical Activity, and Alcohol Intake [interesting results] http://t.co/c4YdElLZXl", "created_at"=>"2014-03-26T04:58:40Z", "user"=>"deejbah", "user_name"=>"Brave Sir Deej", "user_profile_image"=>"http://pbs.twimg.com/profile_images/1552660217/Onthefloorbw_normal.jpg"}
- {"id"=>"448697356595503104", "text"=>"RT @deejbah: Telomere Shortening Unrelated to Smoking, Body Weight, Physical Activity, and Alcohol Intake [interesting results] http://t.co…", "created_at"=>"2014-03-26T05:46:00Z", "user"=>"body88age", "user_name"=>"Flatten Belly Tips", "user_profile_image"=>"http://pbs.twimg.com/profile_images/3769633591/79db7b1fcf66661ac2cba57a30d28f1b_normal.jpeg"}
- {"id"=>"488790843961376768", "text"=>"Telomere shortening unrelated to smoking, body weight, physical activity, and alcohol intake http://t.co/gDCxRw3PEL", "created_at"=>"2014-07-14T21:03:13Z", "user"=>"Science_Reddit", "user_name"=>"Reddit Science", "user_profile_image"=>"http://pbs.twimg.com/profile_images/480229204919742465/DHLw_QAc_normal.png"}
- {"id"=>"488892685617352704", "text"=>"In humans, shortening telomeres are not related to mortality or morbidity. http://t.co/n4ibfZDIim #science #medicine #aging #research", "created_at"=>"2014-07-15T03:47:54Z", "user"=>"CMElrod", "user_name"=>"Chris Elrod", "user_profile_image"=>"http://pbs.twimg.com/profile_images/456117591577071617/T6e6iuf4_normal.jpeg"}
- {"id"=>"489067637511823360", "text"=>"Telomere shortening unrelated to smoking, body weight,physical activity,and alcohol\nhttp://t.co/8cRHawzrKR", "created_at"=>"2014-07-15T15:23:05Z", "user"=>"screech_uk", "user_name"=>"Ieuan Williams", "user_profile_image"=>"http://pbs.twimg.com/profile_images/378800000669153995/945d989f2c8bb3ea1f585c0beca57704_normal.jpeg"}
- {"id"=>"496985205345751040", "text"=>"#Telomere Shortening Unrelated to Smoking, Body Weight, Physical Activity, and Alcohol Intake: 4,576 General P... http://t.co/jDVsXWunQ5", "created_at"=>"2014-08-06T11:44:41Z", "user"=>"DCOutreachInc", "user_name"=>"DC Outreach, Inc.", "user_profile_image"=>"http://pbs.twimg.com/profile_images/482240678986928128/9DpU2Ll8_normal.jpeg"}
- {"id"=>"496992721710903297", "text"=>"RT @DCOutreachInc: #Telomere Shortening Unrelated to Smoking, Body Weight, Physical Activity, and Alcohol Intake: 4,576 General P... http:/…", "created_at"=>"2014-08-06T12:14:33Z", "user"=>"itsanidealworld", "user_name"=>"i.d.e.a.l. Magazine ", "user_profile_image"=>"http://pbs.twimg.com/profile_images/474484443130785792/4NJzBt0t_normal.jpeg"}
Counter
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- {"month"=>"5", "year"=>"2019", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"31"}
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PMC Usage Stats | Further Information
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- {"unique-ip"=>"38", "full-text"=>"37", "pdf"=>"25", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2014", "month"=>"6"}
- {"unique-ip"=>"60", "full-text"=>"64", "pdf"=>"29", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"4"}
- {"unique-ip"=>"19", "full-text"=>"14", "pdf"=>"12", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"7"}
- {"unique-ip"=>"22", "full-text"=>"18", "pdf"=>"10", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"12", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2014", "month"=>"8"}
- {"unique-ip"=>"27", "full-text"=>"21", "pdf"=>"14", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"6", "cited-by"=>"0", "year"=>"2014", "month"=>"9"}
- {"unique-ip"=>"41", "full-text"=>"44", "pdf"=>"18", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2014", "month"=>"10"}
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- {"unique-ip"=>"28", "full-text"=>"31", "pdf"=>"16", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"4"}
- {"unique-ip"=>"17", "full-text"=>"17", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"2", "year"=>"2015", "month"=>"5"}
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- {"unique-ip"=>"19", "full-text"=>"16", "pdf"=>"11", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"1"}
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