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{"title"=>"Genome-Wide Association Study of CSF Levels of 59 Alzheimer's Disease Candidate Proteins: Significant Associations with Proteins Involved in Amyloid Processing and Inflammation", "type"=>"journal", "authors"=>[{"first_name"=>"John S.K.", "last_name"=>"Kauwe", "scopus_author_id"=>"57201215203"}, {"first_name"=>"Matthew H.", "last_name"=>"Bailey", "scopus_author_id"=>"55548772724"}, {"first_name"=>"Perry G.", "last_name"=>"Ridge", "scopus_author_id"=>"23474969500"}, {"first_name"=>"Rachel", "last_name"=>"Perry", "scopus_author_id"=>"24482038600"}, {"first_name"=>"Mark E.", "last_name"=>"Wadsworth", "scopus_author_id"=>"56371454500"}, {"first_name"=>"Kaitlyn L.", "last_name"=>"Hoyt", "scopus_author_id"=>"56371556800"}, {"first_name"=>"Lyndsay A.", "last_name"=>"Staley", "scopus_author_id"=>"56398087200"}, {"first_name"=>"Celeste M.", "last_name"=>"Karch", "scopus_author_id"=>"24460265800"}, {"first_name"=>"Oscar", "last_name"=>"Harari", "scopus_author_id"=>"57195300833"}, {"first_name"=>"Carlos", "last_name"=>"Cruchaga", "scopus_author_id"=>"8280224300"}, {"first_name"=>"Benjamin J.", "last_name"=>"Ainscough", "scopus_author_id"=>"55542315800"}, {"first_name"=>"Kelly", "last_name"=>"Bales", "scopus_author_id"=>"7005760123"}, {"first_name"=>"Eve H.", "last_name"=>"Pickering", "scopus_author_id"=>"14014649300"}, {"first_name"=>"Sarah", "last_name"=>"Bertelsen", "scopus_author_id"=>"7004382710"}, {"first_name"=>"Anne M.", "last_name"=>"Fagan", "scopus_author_id"=>"7006947447"}, {"first_name"=>"David M.", "last_name"=>"Holtzman", "scopus_author_id"=>"35416882500"}, {"first_name"=>"John C.", "last_name"=>"Morris", "scopus_author_id"=>"35355376000"}, {"first_name"=>"Alison M.", "last_name"=>"Goate", "scopus_author_id"=>"7006308333"}], "year"=>2014, "source"=>"PLoS Genetics", "identifiers"=>{"pui"=>"600310988", "sgr"=>"84908311475", "pmid"=>"25340798", "scopus"=>"2-s2.0-84908311475", "isbn"=>"1553-7390", "doi"=>"10.1371/journal.pgen.1004758", "issn"=>"15537404"}, "id"=>"7ffc7ab2-4529-3124-a9e3-fef6373b73a7", "abstract"=>"Cerebrospinal fluid (CSF) 42 amino acid species of amyloid beta (Abeta42) and tau levels are strongly correlated with the presence of Alzheimer's disease (AD) neuropathology including amyloid plaques and neurodegeneration and have been successfully used as endophenotypes for genetic studies of AD. Additional CSF analytes may also serve as useful endophenotypes that capture other aspects of AD pathophysiology. Here we have conducted a genome-wide association study of CSF levels of 59 AD-related analytes. All analytes were measured using the Rules Based Medicine Human DiscoveryMAP Panel, which includes analytes relevant to several disease-related processes. Data from two independently collected and measured datasets, the Knight Alzheimer's Disease Research Center (ADRC) and Alzheimer's Disease Neuroimaging Initiative (ADNI), were analyzed separately, and combined results were obtained using meta-analysis. We identified genetic associations with CSF levels of 5 proteins (Angiotensin-converting enzyme (ACE), Chemokine (C-C motif) ligand 2 (CCL2), Chemokine (C-C motif) ligand 4 (CCL4), Interleukin 6 receptor (IL6R) and Matrix metalloproteinase-3 (MMP3)) with study-wide significant p-values (p<1.46x10-10) and significant, consistent evidence for association in both the Knight ADRC and the ADNI samples. These proteins are involved in amyloid processing and pro-inflammatory signaling. SNPs associated with ACE, IL6R and MMP3 protein levels are located within the coding regions of the corresponding structural gene. The SNPs associated with CSF levels of CCL4 and CCL2 are located in known chemokine binding proteins. The genetic associations reported here are novel and suggest mechanisms for genetic control of CSF and plasma levels of these disease-related proteins. Significant SNPs in ACE and MMP3 also showed association with AD risk. Our findings suggest that these proteins/pathways may be valuable therapeutic targets for AD. Robust associations in cognitively normal individuals suggest that these SNPs also influence regulation of these proteins more generally and may therefore be relevant to other diseases.", "link"=>"http://www.mendeley.com/research/genomewide-association-study-csf-levels-59-alzheimers-disease-candidate-proteins-significant-associa", "reader_count"=>88, "reader_count_by_academic_status"=>{"Unspecified"=>3, "Professor > Associate Professor"=>7, "Librarian"=>2, "Researcher"=>21, "Student > Doctoral Student"=>4, "Student > Ph. D. Student"=>20, "Student > Postgraduate"=>6, "Other"=>7, "Student > Master"=>7, "Student > Bachelor"=>7, "Lecturer > Senior Lecturer"=>1, "Professor"=>3}, "reader_count_by_user_role"=>{"Unspecified"=>3, "Professor > Associate Professor"=>7, "Librarian"=>2, "Researcher"=>21, "Student > Doctoral Student"=>4, "Student > Ph. D. Student"=>20, "Student > Postgraduate"=>6, "Other"=>7, "Student > Master"=>7, "Student > Bachelor"=>7, "Lecturer > Senior Lecturer"=>1, "Professor"=>3}, "reader_count_by_subject_area"=>{"Unspecified"=>4, "Biochemistry, Genetics and Molecular Biology"=>9, "Mathematics"=>1, "Medicine and Dentistry"=>13, "Agricultural and Biological Sciences"=>41, "Neuroscience"=>11, "Pharmacology, Toxicology and Pharmaceutical Science"=>1, "Psychology"=>4, "Chemistry"=>1, "Social Sciences"=>1, "Immunology and Microbiology"=>2}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>13}, "Neuroscience"=>{"Neuroscience"=>11}, "Chemistry"=>{"Chemistry"=>1}, "Social Sciences"=>{"Social Sciences"=>1}, "Psychology"=>{"Psychology"=>4}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>2}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>41}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>9}, "Mathematics"=>{"Mathematics"=>1}, "Unspecified"=>{"Unspecified"=>4}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>1}}, "reader_count_by_country"=>{"Canada"=>1, "United States"=>3, "Australia"=>1, "Spain"=>1}, "group_count"=>4}

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• http://doi.org/10.1155/2017/4626540
• http://doi.org/10.3389/fnagi.2016.00171
• http://doi.org/10.1186/s13195-017-0266-6
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• http://doi.org/10.1093/hmg/ddw366
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• http://doi.org/10.1080/07315724.2018.1487346
• http://doi.org/10.1007/s00018-017-2463-7
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• http://doi.org/10.1038/s41380-018-0055-z
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• http://doi.org/10.1016/j.neurobiolaging.2016.08.019
• http://doi.org/10.1016/j.neurobiolaging.2015.09.009

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• {"id"=>"525643125927051265", "text"=>"Published! #PLOSGenetics: Genome-Wide Association Study of CSF Levels of 59 Alzheimer's Disease Candidate Proteins.. http://t.co/XNckC7BwXx", "created_at"=>"2014-10-24T13:41:01Z", "user"=>"b_ains", "user_name"=>"Ben Ainscough", "user_profile_image"=>"http://pbs.twimg.com/profile_images/463401720874156032/ypZtEqnQ_normal.jpeg"}
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Figshare

• {"files"=>["https://ndownloader.figshare.com/files/1761185"], "description"=>"<p>For each SNP the rs number (SNP, the chromosome (CHR), base pair position (BP) primary associated analyte (Primary), p-value from joint phenotype testing in the Knight ADRC and ADNI samples, and the additional associated phenotypes (Secondary) after Bonferroni correction for 28 SNPs (alpha = 0.0018) is shown.</p><p>Multiphen analysis.</p>", "links"=>[], "tags"=>["ccl", "IL 6R", "Disease Neuroimaging Initiative", "association", "adni", "alzheimer", "snp", "amyloid", "ADRC", "ace", "Medicine Human DiscoveryMAP Panel", "MMP 3 protein levels", "chemokine binding proteins", "CSF levels", "Inflammation Cerebrospinal fluid", "Disease Research Center", "Additional CSF analytes", "ad", "Disease Candidate Proteins"], "article_id"=>1219757, "categories"=>["Biological Sciences"], "users"=>["John S. K. Kauwe", "Matthew H. Bailey", "Perry G. Ridge", "Rachel Perry", "Mark E. Wadsworth", "Kaitlyn L. Hoyt", "Lyndsay A. Staley", "Celeste M. Karch", "Oscar Harari", "Carlos Cruchaga", "Benjamin J. Ainscough", "Kelly Bales", "Eve H. Pickering", "Sarah Bertelsen", "Anne M. Fagan", "David M. Holtzman", "John C. Morris", "Alison M. Goate"], "doi"=>"https://dx.doi.org/10.1371/journal.pgen.1004758.t004", "stats"=>{"downloads"=>3, "page_views"=>12, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Multiphen_analysis_/1219757", "title"=>"Multiphen analysis.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-10-23 16:39:05"}
• {"files"=>["https://ndownloader.figshare.com/files/1761183"], "description"=>"<p>Results of association with respective plasma analytes, CSF analytes levels in samples with low AB42 (evidence of amyloid deposition), those with high AB42 (no evidence of deposition) is shown for each SNP from <a href=\"http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1004758#pgen-1004758-t002\" target=\"_blank\">table 2</a>. In each case the direction of the association is consistent with the original association reported in <a href=\"http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1004758#pgen-1004758-t002\" target=\"_blank\">Table 2</a>. Also shown is results of association with AD status (including BETA and Standard Error, from IGAP Stage 1 analysis <a href=\"http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1004758#pgen.1004758-Lambert1\" target=\"_blank\">[30]</a>; the sign of Beta has been adjusted to reflect the Effect Allele in <a href=\"http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1004758#pgen-1004758-t003\" target=\"_blank\">Table 3</a> for each marker as appropriate), CSF AB42 levels, CSF Tau levels and CSF pTau levels (p-values from Cruchaga et al 2013 <a href=\"http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1004758#pgen.1004758-Cruchaga2\" target=\"_blank\">[9]</a>) are shown. Finally, other phenotypes for which the SNP has shown genome-wide significance in the NHGRI GWAS catalog are presented.</p><p>Association of top hits with additional phenotypes of interest.</p>", "links"=>[], "tags"=>["ccl", "IL 6R", "Disease Neuroimaging Initiative", "association", "adni", "alzheimer", "snp", "amyloid", "ADRC", "ace", "Medicine Human DiscoveryMAP Panel", "MMP 3 protein levels", "chemokine binding proteins", "CSF levels", "Inflammation Cerebrospinal fluid", "Disease Research Center", "Additional CSF analytes", "ad", "Disease Candidate Proteins"], "article_id"=>1219756, "categories"=>["Biological Sciences"], "users"=>["John S. K. Kauwe", "Matthew H. Bailey", "Perry G. Ridge", "Rachel Perry", "Mark E. Wadsworth", "Kaitlyn L. Hoyt", "Lyndsay A. Staley", "Celeste M. Karch", "Oscar Harari", "Carlos Cruchaga", "Benjamin J. Ainscough", "Kelly Bales", "Eve H. Pickering", "Sarah Bertelsen", "Anne M. Fagan", "David M. Holtzman", "John C. Morris", "Alison M. Goate"], "doi"=>"https://dx.doi.org/10.1371/journal.pgen.1004758.t003", "stats"=>{"downloads"=>4, "page_views"=>11, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Association_of_top_hits_with_additional_phenotypes_of_interest_/1219756", "title"=>"Association of top hits with additional phenotypes of interest.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-10-23 16:39:05"}
• {"files"=>["https://ndownloader.figshare.com/files/1761177"], "description"=>"<p>The name of each “AD-related” analyte in the Human Discovery MAP panel, official protein name and official structural gene name are presented.</p><p>Analyte names.</p>", "links"=>[], "tags"=>["ccl", "IL 6R", "Disease Neuroimaging Initiative", "association", "adni", "alzheimer", "snp", "amyloid", "ADRC", "ace", "Medicine Human DiscoveryMAP Panel", "MMP 3 protein levels", "chemokine binding proteins", "CSF levels", "Inflammation Cerebrospinal fluid", "Disease Research Center", "Additional CSF analytes", "ad", "Disease Candidate Proteins"], "article_id"=>1219753, "categories"=>["Biological Sciences"], "users"=>["John S. K. Kauwe", "Matthew H. Bailey", "Perry G. Ridge", "Rachel Perry", "Mark E. Wadsworth", "Kaitlyn L. Hoyt", "Lyndsay A. Staley", "Celeste M. Karch", "Oscar Harari", "Carlos Cruchaga", "Benjamin J. Ainscough", "Kelly Bales", "Eve H. Pickering", "Sarah Bertelsen", "Anne M. Fagan", "David M. Holtzman", "John C. Morris", "Alison M. Goate"], "doi"=>"https://dx.doi.org/10.1371/journal.pgen.1004758.t001", "stats"=>{"downloads"=>3, "page_views"=>17, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Analyte_names_/1219753", "title"=>"Analyte names.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-10-23 16:39:05"}
• {"files"=>["https://ndownloader.figshare.com/files/1761175"], "description"=>"<p>A) region of rs4968782 (<i>ACE</i>), B) region of rs2228467 (<i>CCL2</i>), C) region of rs6808835 (<i>CCL4</i>), D) region of rs61812598 (<i>IL6R</i>), E) region of rs573521 (<i>MMP3</i>). The top SNP for each region is shown in purple. The correlations (r²) of each of the surrounding SNPs to the top SNP are shown in the indicated colors. Recombination rate is shown in blue. SNP annotation is as follows: circle = framestop, square-splice, diamond = nonsynonymous, triangle = coding, inverted triangle = UTR, X = conserved transcription factor binding, square with X = MCS44Placental, star = no annotation, circle with crosshairs = none.</p>", "links"=>[], "tags"=>["ccl", "IL 6R", "Disease Neuroimaging Initiative", "association", "adni", "alzheimer", "snp", "amyloid", "ADRC", "ace", "Medicine Human DiscoveryMAP Panel", "MMP 3 protein levels", "chemokine binding proteins", "CSF levels", "Inflammation Cerebrospinal fluid", "Disease Research Center", "Additional CSF analytes", "ad", "Disease Candidate Proteins"], "article_id"=>1219752, "categories"=>["Biological Sciences"], "users"=>["John S. K. Kauwe", "Matthew H. Bailey", "Perry G. Ridge", "Rachel Perry", "Mark E. Wadsworth", "Kaitlyn L. Hoyt", "Lyndsay A. Staley", "Celeste M. Karch", "Oscar Harari", "Carlos Cruchaga", "Benjamin J. Ainscough", "Kelly Bales", "Eve H. Pickering", "Sarah Bertelsen", "Anne M. Fagan", "David M. Holtzman", "John C. Morris", "Alison M. Goate"], "doi"=>"https://dx.doi.org/10.1371/journal.pgen.1004758.g001", "stats"=>{"downloads"=>1, "page_views"=>11, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Plots_for_the_region_surrounding_the_genome_wide_significant_locus_for_each_phenotype_/1219752", "title"=>"Plots for the region surrounding the genome-wide significant locus for each phenotype.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-10-23 16:39:05"}
• {"files"=>["https://ndownloader.figshare.com/files/1761202", "https://ndownloader.figshare.com/files/1761203", "https://ndownloader.figshare.com/files/1761204", "https://ndownloader.figshare.com/files/1761205", "https://ndownloader.figshare.com/files/1761206", "https://ndownloader.figshare.com/files/1761207", "https://ndownloader.figshare.com/files/1761208", "https://ndownloader.figshare.com/files/1761209", "https://ndownloader.figshare.com/files/1761210", "https://ndownloader.figshare.com/files/1761212", "https://ndownloader.figshare.com/files/1761213"], "description"=>"<div><p>Cerebrospinal fluid (CSF) 42 amino acid species of amyloid beta (Aβ42) and tau levels are strongly correlated with the presence of Alzheimer's disease (AD) neuropathology including amyloid plaques and neurodegeneration and have been successfully used as endophenotypes for genetic studies of AD. Additional CSF analytes may also serve as useful endophenotypes that capture other aspects of AD pathophysiology. Here we have conducted a genome-wide association study of CSF levels of 59 AD-related analytes. All analytes were measured using the Rules Based Medicine Human DiscoveryMAP Panel, which includes analytes relevant to several disease-related processes. Data from two independently collected and measured datasets, the Knight Alzheimer's Disease Research Center (ADRC) and Alzheimer's Disease Neuroimaging Initiative (ADNI), were analyzed separately, and combined results were obtained using meta-analysis. We identified genetic associations with CSF levels of 5 proteins (Angiotensin-converting enzyme (ACE), Chemokine (C-C motif) ligand 2 (CCL2), Chemokine (C-C motif) ligand 4 (CCL4), Interleukin 6 receptor (IL6R) and Matrix metalloproteinase-3 (MMP3)) with study-wide significant p-values (p<1.46×10⁻¹⁰) and significant, consistent evidence for association in both the Knight ADRC and the ADNI samples. These proteins are involved in amyloid processing and pro-inflammatory signaling. SNPs associated with ACE, IL6R and MMP3 protein levels are located within the coding regions of the corresponding structural gene. The SNPs associated with CSF levels of CCL4 and CCL2 are located in known chemokine binding proteins. The genetic associations reported here are novel and suggest mechanisms for genetic control of CSF and plasma levels of these disease-related proteins. Significant SNPs in ACE and MMP3 also showed association with AD risk. Our findings suggest that these proteins/pathways may be valuable therapeutic targets for AD. Robust associations in cognitively normal individuals suggest that these SNPs also influence regulation of these proteins more generally and may therefore be relevant to other diseases.</p></div>", "links"=>[], "tags"=>["ccl", "IL 6R", "Disease Neuroimaging Initiative", "association", "adni", "alzheimer", "snp", "amyloid", "ADRC", "ace", "Medicine Human DiscoveryMAP Panel", "MMP 3 protein levels", "chemokine binding proteins", "CSF levels", "Inflammation Cerebrospinal fluid", "Disease Research Center", "Additional CSF analytes", "ad", "Disease Candidate Proteins"], "article_id"=>1219761, "categories"=>["Biological Sciences"], "users"=>["John S. K. Kauwe", "Matthew H. Bailey", "Perry G. Ridge", "Rachel Perry", "Mark E. Wadsworth", "Kaitlyn L. Hoyt", "Lyndsay A. Staley", "Celeste M. Karch", "Oscar Harari", "Carlos Cruchaga", "Benjamin J. Ainscough", "Kelly Bales", "Eve H. Pickering", "Sarah Bertelsen", "Anne M. Fagan", "David M. Holtzman", "John C. Morris", "Alison M. Goate"], "doi"=>["https://dx.doi.org/10.1371/journal.pgen.1004758.s001", "https://dx.doi.org/10.1371/journal.pgen.1004758.s002", "https://dx.doi.org/10.1371/journal.pgen.1004758.s003", "https://dx.doi.org/10.1371/journal.pgen.1004758.s004", "https://dx.doi.org/10.1371/journal.pgen.1004758.s005", "https://dx.doi.org/10.1371/journal.pgen.1004758.s006", "https://dx.doi.org/10.1371/journal.pgen.1004758.s007", "https://dx.doi.org/10.1371/journal.pgen.1004758.s008", "https://dx.doi.org/10.1371/journal.pgen.1004758.s009", "https://dx.doi.org/10.1371/journal.pgen.1004758.s010", "https://dx.doi.org/10.1371/journal.pgen.1004758.s011"], "stats"=>{"downloads"=>12, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Genome_Wide_Association_Study_of_CSF_Levels_of_59_Alzheimer_s_Disease_Candidate_Proteins_Significant_Associations_with_Proteins_Involved_in_Amyloid_Processing_and_Inflammation_/1219761", "title"=>"Genome-Wide Association Study of CSF Levels of 59 Alzheimer's Disease Candidate Proteins: Significant Associations with Proteins Involved in Amyloid Processing and Inflammation", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2014-10-23 16:39:05"}
• {"files"=>["https://ndownloader.figshare.com/files/1761187"], "description"=>"<p>For samples from the Knight Alzheimer's Disease Research Center and Alzheimer's Disease Neuroimaging Initiative the number of samples, percent female, percent of APOE e4 carriers, percent of non-demented (CDR = 0) samples, percent amyloid positive, percent of CDR = 0 samples that are amyloid positive, percent of CDR> = 0.5 samples that were amyloid positive) and mean and standard deviation of the key analytes from this study are shown.</p><p>*Amyloid positivity is inferred from CSF AB42 levels (KADRC AB42<500 pg/ml; ADNI AB42<192 pg/ml).</p><p>**ADNI phenotypes were obtained from ADNI after transformation to approximate a normal distribution.</p><p>Sample characteristics.</p>", "links"=>[], "tags"=>["ccl", "IL 6R", "Disease Neuroimaging Initiative", "association", "adni", "alzheimer", "snp", "amyloid", "ADRC", "ace", "Medicine Human DiscoveryMAP Panel", "MMP 3 protein levels", "chemokine binding proteins", "CSF levels", "Inflammation Cerebrospinal fluid", "Disease Research Center", "Additional CSF analytes", "ad", "Disease Candidate Proteins"], "article_id"=>1219758, "categories"=>["Biological Sciences"], "users"=>["John S. K. Kauwe", "Matthew H. Bailey", "Perry G. Ridge", "Rachel Perry", "Mark E. Wadsworth", "Kaitlyn L. Hoyt", "Lyndsay A. Staley", "Celeste M. Karch", "Oscar Harari", "Carlos Cruchaga", "Benjamin J. Ainscough", "Kelly Bales", "Eve H. Pickering", "Sarah Bertelsen", "Anne M. Fagan", "David M. Holtzman", "John C. Morris", "Alison M. Goate"], "doi"=>"https://dx.doi.org/10.1371/journal.pgen.1004758.t005", "stats"=>{"downloads"=>1, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Sample_characteristics_/1219758", "title"=>"Sample characteristics.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-10-23 16:39:05"}
• {"files"=>["https://ndownloader.figshare.com/files/1761180"], "description"=>"<p>This table includes the following SNPs for each phenotype with significantly associated variants: the most significant marker, all significant SNPs with putative function, Regulome scores of 1 or 2, and all SNPs that have previous records in the NHGRI catalog of published genome-wide association studies (downloaded November 19th, 2013). For each marker the chromosome (CHR), base pair position (BP), Alleles (Non-effect allele, effect allele), p-value from the ADNI dataset (ADNI), p-value from the Knight ADRC dataset (Knight ADRC), combined sample p-value (Combined), direction of association with respect to the effect allele (Effect Direction), variance explained by the marker in the discovery series (ADNI r²), minor allele frequency (MAF), Nearest Gene, Functional annotation (Function), and Regulome Score is provided.</p><p>Selected study-wide significant results.</p>", "links"=>[], "tags"=>["ccl", "IL 6R", "Disease Neuroimaging Initiative", "association", "adni", "alzheimer", "snp", "amyloid", "ADRC", "ace", "Medicine Human DiscoveryMAP Panel", "MMP 3 protein levels", "chemokine binding proteins", "CSF levels", "Inflammation Cerebrospinal fluid", "Disease Research Center", "Additional CSF analytes", "ad", "Disease Candidate Proteins"], "article_id"=>1219754, "categories"=>["Biological Sciences"], "users"=>["John S. K. Kauwe", "Matthew H. Bailey", "Perry G. Ridge", "Rachel Perry", "Mark E. Wadsworth", "Kaitlyn L. Hoyt", "Lyndsay A. Staley", "Celeste M. Karch", "Oscar Harari", "Carlos Cruchaga", "Benjamin J. Ainscough", "Kelly Bales", "Eve H. Pickering", "Sarah Bertelsen", "Anne M. Fagan", "David M. Holtzman", "John C. Morris", "Alison M. Goate"], "doi"=>"https://dx.doi.org/10.1371/journal.pgen.1004758.t002", "stats"=>{"downloads"=>3, "page_views"=>17, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Selected_study_wide_significant_results_/1219754", "title"=>"Selected study-wide significant results.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-10-23 16:39:05"}

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Relative Metric

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F1000Prime