Genome-wide Association Study Identifies Shared Risk Loci Common to Two Malignancies in Golden Retrievers
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{"title"=>"Genome-wide Association Study Identifies Shared Risk Loci Common to Two Malignancies in Golden Retrievers", "type"=>"journal", "authors"=>[{"first_name"=>"Noriko", "last_name"=>"Tonomura", "scopus_author_id"=>"55962730100"}, {"first_name"=>"Ingegerd", "last_name"=>"Elvers", "scopus_author_id"=>"23389179400"}, {"first_name"=>"Rachael", "last_name"=>"Thomas", "scopus_author_id"=>"9841779300"}, {"first_name"=>"Kate", "last_name"=>"Megquier", "scopus_author_id"=>"56543813400"}, {"first_name"=>"Jason", "last_name"=>"Turner-Maier", "scopus_author_id"=>"51864998900"}, {"first_name"=>"Cedric", "last_name"=>"Howald", "scopus_author_id"=>"6602252392"}, {"first_name"=>"Aaron L.", "last_name"=>"Sarver", "scopus_author_id"=>"26323353800"}, {"first_name"=>"Ross", "last_name"=>"Swofford", "scopus_author_id"=>"42062318300"}, {"first_name"=>"Aric M.", "last_name"=>"Frantz", "scopus_author_id"=>"55260432500"}, {"first_name"=>"Daisuke", "last_name"=>"Ito", "scopus_author_id"=>"27169255100"}, {"first_name"=>"Evan", "last_name"=>"Mauceli", "scopus_author_id"=>"6602549898"}, {"first_name"=>"Maja", "last_name"=>"Arendt", "scopus_author_id"=>"55565563500"}, {"first_name"=>"Hyun Ji", "last_name"=>"Noh", "scopus_author_id"=>"55820158900"}, {"first_name"=>"Michele", "last_name"=>"Koltookian", "scopus_author_id"=>"56543676400"}, {"first_name"=>"Tara", "last_name"=>"Biagi", "scopus_author_id"=>"9743060700"}, {"first_name"=>"Sarah", "last_name"=>"Fryc", "scopus_author_id"=>"41361086200"}, {"first_name"=>"Christina", "last_name"=>"Williams", "scopus_author_id"=>"55574209986"}, {"first_name"=>"Anne C.", "last_name"=>"Avery", "scopus_author_id"=>"7006218334"}, {"first_name"=>"Jong Hyuk", "last_name"=>"Kim", "scopus_author_id"=>"35109326200"}, {"first_name"=>"Lisa", "last_name"=>"Barber", "scopus_author_id"=>"7102574941"}, {"first_name"=>"Kristine", "last_name"=>"Burgess", "scopus_author_id"=>"35820977800"}, {"first_name"=>"Eric S.", "last_name"=>"Lander", "scopus_author_id"=>"16151582900"}, {"first_name"=>"Elinor K.", "last_name"=>"Karlsson", "scopus_author_id"=>"9839207000"}, {"first_name"=>"Chieko", "last_name"=>"Azuma", "scopus_author_id"=>"56542987400"}, {"first_name"=>"Jaime F.", "last_name"=>"Modiano", "scopus_author_id"=>"7003997675"}, {"first_name"=>"Matthew", "last_name"=>"Breen", "scopus_author_id"=>"7103338353"}, {"first_name"=>"Kerstin", "last_name"=>"Lindblad-Toh", "scopus_author_id"=>"6603065092"}], "year"=>2015, "source"=>"PLoS Genetics", "identifiers"=>{"pui"=>"602901804", "isbn"=>"1553-7404 (Electronic) 1553-7390 (Linking)", "issn"=>"15537404", "doi"=>"10.1371/journal.pgen.1004922", "scopus"=>"2-s2.0-84924422639", "pmid"=>"25642983", "sgr"=>"84924422639"}, "id"=>"62b433f7-7b98-3262-988c-aee1fe1ebbfe", "abstract"=>"Dogs, with their breed-determined limited genetic background, are great models of human disease including cancer. Canine B-cell lymphoma and hemangiosarcoma are both malignancies of the hematologic system that are clinically and histologically similar to human B-cell non-Hodgkin lymphoma and angiosarcoma, respectively. Golden retrievers in the US show significantly elevated lifetime risk for both B-cell lymphoma (6%) and hemangiosarcoma (20%). We conducted genome-wide association studies for hemangiosarcoma and B-cell lymphoma, identifying two shared predisposing loci. The two associated loci are located on chromosome 5, and together contribute ~20% of the risk of developing these cancers. Genome-wide p-values for the top SNP of each locus are 4.6×10-7 and 2.7×10-6, respectively. Whole genome resequencing of nine cases and controls followed by genotyping and detailed analysis identified three shared and one B-cell lymphoma specific risk haplotypes within the two loci, but no coding changes were associated with the risk haplotypes. Gene expression analysis of B-cell lymphoma tumors revealed that carrying the risk haplotypes at the first locus is associated with down-regulation of several nearby genes including the proximal gene TRPC6, a transient receptor Ca2+-channel involved in T-cell activation, among other functions. The shared risk haplotype in the second locus overlaps the vesicle transport and release gene STX8. Carrying the shared risk haplotype is associated with gene expression changes of 100 genes enriched for pathways involved in immune cell activation. Thus, the predisposing germ-line mutations in B-cell lymphoma and hemangiosarcoma appear to be regulatory, and affect pathways involved in T-cell mediated immune response in the tumor. This suggests that the interaction between the immune system and malignant cells plays a common role in the tumorigenesis of these relatively different cancers.", "link"=>"http://www.mendeley.com/research/genomewide-association-study-identifies-shared-risk-loci-common-two-malignancies-golden-retrievers", "reader_count"=>64, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>3, "Librarian"=>2, "Researcher"=>14, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>13, "Student > Postgraduate"=>3, "Student > Master"=>9, "Other"=>9, "Student > Bachelor"=>5, "Professor"=>3, "Unspecified"=>1}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>3, "Librarian"=>2, "Researcher"=>14, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>13, "Student > Postgraduate"=>3, "Student > Master"=>9, "Other"=>9, "Student > Bachelor"=>5, "Professor"=>3, "Unspecified"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>2, "Biochemistry, Genetics and Molecular Biology"=>6, "Mathematics"=>1, "Agricultural and Biological Sciences"=>26, "Medicine and Dentistry"=>10, "Veterinary Science and Veterinary Medicine"=>14, "Social Sciences"=>1, "Computer Science"=>4}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>10}, "Social Sciences"=>{"Social Sciences"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>26}, "Computer Science"=>{"Computer Science"=>4}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>6}, "Mathematics"=>{"Mathematics"=>1}, "Unspecified"=>{"Unspecified"=>2}, "Veterinary Science and Veterinary Medicine"=>{"Veterinary Science and Veterinary Medicine"=>14}}, "reader_count_by_country"=>{"Austria"=>1, "Sweden"=>1, "Hungary"=>1, "United States"=>3, "Japan"=>1}, "group_count"=>2}

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/1878277"], "description"=>"<p>List of significantly associated haplotypes.</p>", "links"=>[], "tags"=>["risk haplotypes", "lymphoma", "snp", "gene expression changes", "Whole genome resequencing", "gene expression analysis", "locus", "risk haplotype", "hemangiosarcoma", "trpc", "Golden Retrievers Dogs", "loci", "release gene STX 8."], "article_id"=>1299582, "categories"=>["Uncategorised"], "users"=>["Noriko Tonomura", "Ingegerd Elvers", "Rachael Thomas", "Kate Megquier", "Jason Turner-Maier", "Cédric Howald", "Aaron L. Sarver", "Ross Swofford", "Aric M. Frantz", "Daisuke Ito", "Evan Mauceli", "Maja Arendt", "Hyun Ji Noh", "Michele Koltookian", "Tara Biagi", "Sarah Fryc", "Christina Williams", "Anne C. Avery", "Jong-Hyuk Kim", "Lisa Barber", "Kristine Burgess", "Eric S. Lander", "Elinor K. Karlsson", "Chieko Azuma", "Jaime F. Modiano", "Matthew Breen", "Kerstin Lindblad-Toh"], "doi"=>"https://dx.doi.org/10.1371/journal.pgen.1004922.t002", "stats"=>{"downloads"=>3, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_List_of_significantly_associated_haplotypes_/1299582", "title"=>"List of significantly associated haplotypes.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-02-02 02:44:11"}
  • {"files"=>["https://ndownloader.figshare.com/files/1878274"], "description"=>"<p>A. The top SNP of the first peak (29 Mb) is in high LD with nearby variants and shows no evidence of linkage to the top SNPs in the second peak (33 Mb). B. The 29 Mb peak is comprised of two haplotype blocks, and C. the risk haplotypes for the 29 Mb peak are rather common in the population. Similarly, D. the second peak also shows no linkage with the first peak in the combined analysis, whereas E. analysis of only B-cell lymphoma shows SNPs in strong LD within the second peak and in moderate LD with SNPs in the first peak. The top SNPs in the combined analysis and B-cell-lymphoma-only analysis are independent, and F. make up separate haplotypes at the second locus. G. Both risk haplotypes at the second locus are rare. Color-coding of SNPs in A, D, E, reflects their r<sup>2</sup> value relative the top SNP of that region, ranging from grey (not in LD) to red (strong LD).</p>", "links"=>[], "tags"=>["risk haplotypes", "lymphoma", "snp", "gene expression changes", "Whole genome resequencing", "gene expression analysis", "locus", "risk haplotype", "hemangiosarcoma", "trpc", "Golden Retrievers Dogs", "loci", "release gene STX 8."], "article_id"=>1299579, "categories"=>["Uncategorised"], "users"=>["Noriko Tonomura", "Ingegerd Elvers", "Rachael Thomas", "Kate Megquier", "Jason Turner-Maier", "Cédric Howald", "Aaron L. Sarver", "Ross Swofford", "Aric M. Frantz", "Daisuke Ito", "Evan Mauceli", "Maja Arendt", "Hyun Ji Noh", "Michele Koltookian", "Tara Biagi", "Sarah Fryc", "Christina Williams", "Anne C. Avery", "Jong-Hyuk Kim", "Lisa Barber", "Kristine Burgess", "Eric S. Lander", "Elinor K. Karlsson", "Chieko Azuma", "Jaime F. Modiano", "Matthew Breen", "Kerstin Lindblad-Toh"], "doi"=>"https://dx.doi.org/10.1371/journal.pgen.1004922.g002", "stats"=>{"downloads"=>0, "page_views"=>15, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Two_neighboring_loci_on_chromosome_5_are_independently_associated_with_disease_risk_/1299579", "title"=>"Two neighboring loci on chromosome 5 are independently associated with disease risk.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-02-02 02:44:11"}
  • {"files"=>["https://ndownloader.figshare.com/files/1878273"], "description"=>"<p>A. Association of 142 cases with hemangiosarcoma and 172 healthy controls. The inflation factor λ of this analysis is 0.959, indicating that the population stratification had been properly controlled. The observed p-values deviated from the null beyond 95% confidence interval at-logP = 3.84, with a strong peak on chromosome 5, and a few SNPs on other chromosomes reaching significance. B. Analysis of 41 B-cell lymphoma cases and 172 healthy controls (λ = 0.976). C. As both lymphoma and hemangiosarcoma were most strongly associated to the same region on chromosome 5, the datasets were combined (142 hemangiosarcoma + 41 B-cell lymphoma cases and 172 controls) and reanalyzed for association, resulting in an increased association signal on chromosome 5 at p-value of 4.63 × 10<sup>−7</sup> (λ = 0.988, significance threshold-logP = 3.66). Sex and the first PC was used as covariates in all association studies.</p>", "links"=>[], "tags"=>["risk haplotypes", "lymphoma", "snp", "gene expression changes", "Whole genome resequencing", "gene expression analysis", "locus", "risk haplotype", "hemangiosarcoma", "trpc", "Golden Retrievers Dogs", "loci", "release gene STX 8."], "article_id"=>1299578, "categories"=>["Uncategorised"], "users"=>["Noriko Tonomura", "Ingegerd Elvers", "Rachael Thomas", "Kate Megquier", "Jason Turner-Maier", "Cédric Howald", "Aaron L. Sarver", "Ross Swofford", "Aric M. Frantz", "Daisuke Ito", "Evan Mauceli", "Maja Arendt", "Hyun Ji Noh", "Michele Koltookian", "Tara Biagi", "Sarah Fryc", "Christina Williams", "Anne C. Avery", "Jong-Hyuk Kim", "Lisa Barber", "Kristine Burgess", "Eric S. Lander", "Elinor K. Karlsson", "Chieko Azuma", "Jaime F. Modiano", "Matthew Breen", "Kerstin Lindblad-Toh"], "doi"=>"https://dx.doi.org/10.1371/journal.pgen.1004922.g001", "stats"=>{"downloads"=>0, "page_views"=>19, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Genome_wide_association_of_hemangiosarcoma_and_B_cell_lymphoma_identifies_chromosome_5_as_a_common_risk_factor_/1299578", "title"=>"Genome-wide association of hemangiosarcoma and B-cell lymphoma identifies chromosome 5 as a common risk factor.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-02-02 02:44:11"}
  • {"files"=>["https://ndownloader.figshare.com/files/1878276"], "description"=>"<p>List of significantly associated SNPs from each GWAS.</p>", "links"=>[], "tags"=>["risk haplotypes", "lymphoma", "snp", "gene expression changes", "Whole genome resequencing", "gene expression analysis", "locus", "risk haplotype", "hemangiosarcoma", "trpc", "Golden Retrievers Dogs", "loci", "release gene STX 8."], "article_id"=>1299581, "categories"=>["Uncategorised"], "users"=>["Noriko Tonomura", "Ingegerd Elvers", "Rachael Thomas", "Kate Megquier", "Jason Turner-Maier", "Cédric Howald", "Aaron L. Sarver", "Ross Swofford", "Aric M. Frantz", "Daisuke Ito", "Evan Mauceli", "Maja Arendt", "Hyun Ji Noh", "Michele Koltookian", "Tara Biagi", "Sarah Fryc", "Christina Williams", "Anne C. Avery", "Jong-Hyuk Kim", "Lisa Barber", "Kristine Burgess", "Eric S. Lander", "Elinor K. Karlsson", "Chieko Azuma", "Jaime F. Modiano", "Matthew Breen", "Kerstin Lindblad-Toh"], "doi"=>"https://dx.doi.org/10.1371/journal.pgen.1004922.t001", "stats"=>{"downloads"=>6, "page_views"=>22, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_List_of_significantly_associated_SNPs_from_each_GWAS_/1299581", "title"=>"List of significantly associated SNPs from each GWAS.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-02-02 02:44:11"}
  • {"files"=>["https://ndownloader.figshare.com/files/1878275"], "description"=>"<p>A. The risk allele at the 29 Mb at homozygous state has a clear cis-regulation effect on the expression levels of <i>TRPC6</i>, <i>KIAA1377</i>, and <i>ANGPTL5</i>, three of the most proximal genes. <i>BIRC3</i>, which is also proximal to the 29 Mb risk locus, had a significant p-value, however the FDR value was slightly above the threshold of 0.05. The risk allele at 29 Mb was also associated with a regulatory effect on genes near the 33 Mb locus and a change in the expression of <i>PIK3R6</i> significantly. B. A large network of molecules that play a major role in activation of T-lymphocyte and other immune cells (IPA category: cell-to-cell signaling and interaction, hematological system development and function). This network includes 15 molecules of which expressions are significantly altered in individuals carrying at least one copy of the shared risk allele at the 33 Mb locus. The outcomes of such expression changes are significantly linked to decrease in T-cell activation.</p>", "links"=>[], "tags"=>["risk haplotypes", "lymphoma", "snp", "gene expression changes", "Whole genome resequencing", "gene expression analysis", "locus", "risk haplotype", "hemangiosarcoma", "trpc", "Golden Retrievers Dogs", "loci", "release gene STX 8."], "article_id"=>1299580, "categories"=>["Uncategorised"], "users"=>["Noriko Tonomura", "Ingegerd Elvers", "Rachael Thomas", "Kate Megquier", "Jason Turner-Maier", "Cédric Howald", "Aaron L. Sarver", "Ross Swofford", "Aric M. Frantz", "Daisuke Ito", "Evan Mauceli", "Maja Arendt", "Hyun Ji Noh", "Michele Koltookian", "Tara Biagi", "Sarah Fryc", "Christina Williams", "Anne C. Avery", "Jong-Hyuk Kim", "Lisa Barber", "Kristine Burgess", "Eric S. Lander", "Elinor K. Karlsson", "Chieko Azuma", "Jaime F. Modiano", "Matthew Breen", "Kerstin Lindblad-Toh"], "doi"=>"https://dx.doi.org/10.1371/journal.pgen.1004922.g003", "stats"=>{"downloads"=>0, "page_views"=>16, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Differentially_expressed_genes_by_the_risk_alleles_at_29_Mb_and_33_Mb_play_important_role_in_T_cell_immunity_/1299580", "title"=>"Differentially expressed genes by the risk alleles at 29 Mb and 33 Mb play important role in T-cell immunity.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-02-02 02:44:11"}
  • {"files"=>["https://ndownloader.figshare.com/files/1878280", "https://ndownloader.figshare.com/files/1878281", "https://ndownloader.figshare.com/files/1878282", "https://ndownloader.figshare.com/files/1878283", "https://ndownloader.figshare.com/files/1878284", "https://ndownloader.figshare.com/files/1878285", "https://ndownloader.figshare.com/files/1878286", "https://ndownloader.figshare.com/files/1878287", "https://ndownloader.figshare.com/files/1878288", "https://ndownloader.figshare.com/files/1878289", "https://ndownloader.figshare.com/files/1878290", "https://ndownloader.figshare.com/files/1878291", "https://ndownloader.figshare.com/files/1878292"], "description"=>"<div><p>Dogs, with their breed-determined limited genetic background, are great models of human disease including cancer. Canine B-cell lymphoma and hemangiosarcoma are both malignancies of the hematologic system that are clinically and histologically similar to human B-cell non-Hodgkin lymphoma and angiosarcoma, respectively. Golden retrievers in the US show significantly elevated lifetime risk for both B-cell lymphoma (6%) and hemangiosarcoma (20%). We conducted genome-wide association studies for hemangiosarcoma and B-cell lymphoma, identifying two shared predisposing loci. The two associated loci are located on chromosome 5, and together contribute ~20% of the risk of developing these cancers. Genome-wide p-values for the top SNP of each locus are 4.6×10<sup>-7</sup> and 2.7×10<sup>-6</sup>, respectively. Whole genome resequencing of nine cases and controls followed by genotyping and detailed analysis identified three shared and one B-cell lymphoma specific risk haplotypes within the two loci, but no coding changes were associated with the risk haplotypes. Gene expression analysis of B-cell lymphoma tumors revealed that carrying the risk haplotypes at the first locus is associated with down-regulation of several nearby genes including the proximal gene <i>TRPC6</i>, a transient receptor Ca<sup>2+</sup>-channel involved in T-cell activation, among other functions. The shared risk haplotype in the second locus overlaps the vesicle transport and release gene <i>STX8</i>. Carrying the shared risk haplotype is associated with gene expression changes of 100 genes enriched for pathways involved in immune cell activation. Thus, the predisposing germ-line mutations in B-cell lymphoma and hemangiosarcoma appear to be regulatory, and affect pathways involved in T-cell mediated immune response in the tumor. This suggests that the interaction between the immune system and malignant cells plays a common role in the tumorigenesis of these relatively different cancers.</p></div>", "links"=>[], "tags"=>["risk haplotypes", "lymphoma", "snp", "gene expression changes", "Whole genome resequencing", "gene expression analysis", "locus", "risk haplotype", "hemangiosarcoma", "trpc", "Golden Retrievers Dogs", "loci", "release gene STX 8."], "article_id"=>1299585, "categories"=>["Uncategorised"], "users"=>["Noriko Tonomura", "Ingegerd Elvers", "Rachael Thomas", "Kate Megquier", "Jason Turner-Maier", "Cédric Howald", "Aaron L. Sarver", "Ross Swofford", "Aric M. Frantz", "Daisuke Ito", "Evan Mauceli", "Maja Arendt", "Hyun Ji Noh", "Michele Koltookian", "Tara Biagi", "Sarah Fryc", "Christina Williams", "Anne C. Avery", "Jong-Hyuk Kim", "Lisa Barber", "Kristine Burgess", "Eric S. Lander", "Elinor K. Karlsson", "Chieko Azuma", "Jaime F. Modiano", "Matthew Breen", "Kerstin Lindblad-Toh"], "doi"=>["https://dx.doi.org/10.1371/journal.pgen.1004922.s001", "https://dx.doi.org/10.1371/journal.pgen.1004922.s002", "https://dx.doi.org/10.1371/journal.pgen.1004922.s003", "https://dx.doi.org/10.1371/journal.pgen.1004922.s004", "https://dx.doi.org/10.1371/journal.pgen.1004922.s005", "https://dx.doi.org/10.1371/journal.pgen.1004922.s006", "https://dx.doi.org/10.1371/journal.pgen.1004922.s007", "https://dx.doi.org/10.1371/journal.pgen.1004922.s008", "https://dx.doi.org/10.1371/journal.pgen.1004922.s009", "https://dx.doi.org/10.1371/journal.pgen.1004922.s010", "https://dx.doi.org/10.1371/journal.pgen.1004922.s011", "https://dx.doi.org/10.1371/journal.pgen.1004922.s012", "https://dx.doi.org/10.1371/journal.pgen.1004922.s013"], "stats"=>{"downloads"=>0, "page_views"=>14, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Genome_wide_Association_Study_Identifies_Shared_Risk_Loci_Common_to_Two_Malignancies_in_Golden_Retrievers_/1299585", "title"=>"Genome-wide Association Study Identifies Shared Risk Loci Common to Two Malignancies in Golden Retrievers", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2015-02-02 02:44:11"}
  • {"files"=>["https://ndownloader.figshare.com/files/1878278"], "description"=>"<p>Top 10 differentially expressed genes by the risk haplotype at each locus.</p>", "links"=>[], "tags"=>["risk haplotypes", "lymphoma", "snp", "gene expression changes", "Whole genome resequencing", "gene expression analysis", "locus", "risk haplotype", "hemangiosarcoma", "trpc", "Golden Retrievers Dogs", "loci", "release gene STX 8."], "article_id"=>1299583, "categories"=>["Uncategorised"], "users"=>["Noriko Tonomura", "Ingegerd Elvers", "Rachael Thomas", "Kate Megquier", "Jason Turner-Maier", "Cédric Howald", "Aaron L. Sarver", "Ross Swofford", "Aric M. Frantz", "Daisuke Ito", "Evan Mauceli", "Maja Arendt", "Hyun Ji Noh", "Michele Koltookian", "Tara Biagi", "Sarah Fryc", "Christina Williams", "Anne C. Avery", "Jong-Hyuk Kim", "Lisa Barber", "Kristine Burgess", "Eric S. Lander", "Elinor K. Karlsson", "Chieko Azuma", "Jaime F. Modiano", "Matthew Breen", "Kerstin Lindblad-Toh"], "doi"=>"https://dx.doi.org/10.1371/journal.pgen.1004922.t003", "stats"=>{"downloads"=>2, "page_views"=>19, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Top_10_differentially_expressed_genes_by_the_risk_haplotype_at_each_locus_/1299583", "title"=>"Top 10 differentially expressed genes by the risk haplotype at each locus.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-02-02 02:44:11"}

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  • {"unique-ip"=>"14", "full-text"=>"14", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"9", "cited-by"=>"0", "year"=>"2018", "month"=>"8"}
  • {"unique-ip"=>"16", "full-text"=>"15", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"9", "cited-by"=>"0", "year"=>"2018", "month"=>"11"}
  • {"unique-ip"=>"13", "full-text"=>"12", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2018", "month"=>"10"}
  • {"unique-ip"=>"19", "full-text"=>"11", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"18", "cited-by"=>"0", "year"=>"2018", "month"=>"12"}
  • {"unique-ip"=>"18", "full-text"=>"14", "pdf"=>"8", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2019", "month"=>"2"}
  • {"unique-ip"=>"12", "full-text"=>"12", "pdf"=>"7", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"3"}
  • {"unique-ip"=>"4", "full-text"=>"2", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"4"}

Relative Metric

{"start_date"=>"2015-01-01T00:00:00Z", "end_date"=>"2015-12-31T00:00:00Z", "subject_areas"=>[]}
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