Resistance to Gray Leaf Spot of Maize: Genetic Architecture and Mechanisms Elucidated through Nested Association Mapping and Near-Isogenic Line Analysis
Events
Loading … Spinner

Mendeley | Further Information

{"title"=>"Resistance to Gray Leaf Spot of Maize: Genetic Architecture and Mechanisms Elucidated through Nested Association Mapping and Near-Isogenic Line Analysis", "type"=>"journal", "authors"=>[{"first_name"=>"Jacqueline M.", "last_name"=>"Benson", "scopus_author_id"=>"57196988572"}, {"first_name"=>"Jesse A.", "last_name"=>"Poland", "scopus_author_id"=>"8851627900"}, {"first_name"=>"Brent M.", "last_name"=>"Benson", "scopus_author_id"=>"56579804700"}, {"first_name"=>"Erik L.", "last_name"=>"Stromberg", "scopus_author_id"=>"6603846868"}, {"first_name"=>"Rebecca J.", "last_name"=>"Nelson", "scopus_author_id"=>"7404561400"}], "year"=>2015, "source"=>"PLoS Genetics", "identifiers"=>{"issn"=>"15537404", "scopus"=>"2-s2.0-84926208487", "sgr"=>"84926208487", "pui"=>"603514010", "pmid"=>"25764179", "doi"=>"10.1371/journal.pgen.1005045"}, "id"=>"5a57b24c-88ed-3625-b452-969f034b9c31", "abstract"=>"Gray leaf spot (GLS), caused by Cercospora zeae-maydis and Cercospora zeina, is one of the most important diseases of maize worldwide. The pathogen has a necrotrophic lifestyle and no major genes are known for GLS. Quantitative resistance, although poorly understood, is important for GLS management. We used genetic mapping to refine understanding of the genetic architecture of GLS resistance and to develop hypotheses regarding the mechanisms underlying quantitative disease resistance (QDR) loci. Nested association mapping (NAM) was used to identify 16 quantitative trait loci (QTL) for QDR to GLS, including seven novel QTL, each of which demonstrated allelic series with significant effects above and below the magnitude of the B73 reference allele. Alleles at three QTL, qGLS1.04, qGLS2.09, and qGLS4.05, conferred disease reductions of greater than 10%. Interactions between loci were detected for three pairs of loci, including an interaction between iqGLS4.05 and qGLS7.03. Near-isogenic lines (NILs) were developed to confirm and fine-map three of the 16 QTL, and to develop hypotheses regarding mechanisms of resistance. qGLS1.04 was fine-mapped from an interval of 27.0 Mb to two intervals of 6.5 Mb and 5.2 Mb, consistent with the hypothesis that multiple genes underlie highly significant QTL identified by NAM. qGLS2.09, which was also associated with maturity (days to anthesis) and with resistance to southern leaf blight, was narrowed to a 4-Mb interval. The distance between major leaf veins was strongly associated with resistance to GLS at qGLS4.05. NILs for qGLS1.04 were treated with the C. zeae-maydis toxin cercosporin to test the role of host-specific toxin in QDR. Cercosporin exposure increased expression of a putative flavin-monooxygenase (FMO) gene, a candidate detoxification-related gene underlying qGLS1.04. This integrated approach to confirming QTL and characterizing the potential underlying mechanisms advances the understanding of QDR and will facilitate the development of resistant varieties.", "link"=>"http://www.mendeley.com/research/resistance-gray-leaf-spot-maize-genetic-architecture-mechanisms-elucidated-through-nested-associatio", "reader_count"=>66, "reader_count_by_academic_status"=>{"Unspecified"=>5, "Professor > Associate Professor"=>4, "Researcher"=>10, "Student > Doctoral Student"=>10, "Student > Ph. D. Student"=>16, "Student > Postgraduate"=>2, "Student > Master"=>9, "Other"=>2, "Student > Bachelor"=>4, "Professor"=>4}, "reader_count_by_user_role"=>{"Unspecified"=>5, "Professor > Associate Professor"=>4, "Researcher"=>10, "Student > Doctoral Student"=>10, "Student > Ph. D. Student"=>16, "Student > Postgraduate"=>2, "Student > Master"=>9, "Other"=>2, "Student > Bachelor"=>4, "Professor"=>4}, "reader_count_by_subject_area"=>{"Unspecified"=>5, "Environmental Science"=>1, "Biochemistry, Genetics and Molecular Biology"=>4, "Agricultural and Biological Sciences"=>55, "Computer Science"=>1}, "reader_count_by_subdiscipline"=>{"Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>55}, "Computer Science"=>{"Computer Science"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>4}, "Unspecified"=>{"Unspecified"=>5}, "Environmental Science"=>{"Environmental Science"=>1}}, "reader_count_by_country"=>{"United States"=>1, "South Africa"=>1, "France"=>1}, "group_count"=>3}

CrossRef

Scopus | Further Information

{"@_fa"=>"true", "link"=>[{"@_fa"=>"true", "@ref"=>"self", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/84926208487"}, {"@_fa"=>"true", "@ref"=>"author-affiliation", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/84926208487?field=author,affiliation"}, {"@_fa"=>"true", "@ref"=>"scopus", "@href"=>"https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84926208487&origin=inward"}, {"@_fa"=>"true", "@ref"=>"scopus-citedby", "@href"=>"https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=84926208487&origin=inward"}], "prism:url"=>"https://api.elsevier.com/content/abstract/scopus_id/84926208487", "dc:identifier"=>"SCOPUS_ID:84926208487", "eid"=>"2-s2.0-84926208487", "dc:title"=>"Resistance to Gray Leaf Spot of Maize: Genetic Architecture and Mechanisms Elucidated through Nested Association Mapping and Near-Isogenic Line Analysis", "dc:creator"=>"Benson J.", "prism:publicationName"=>"PLoS Genetics", "prism:issn"=>"15537390", "prism:eIssn"=>"15537404", "prism:volume"=>"11", "prism:issueIdentifier"=>"3", "prism:pageRange"=>nil, "prism:coverDate"=>"2015-03-12", "prism:coverDisplayDate"=>"12 March 2015", "prism:doi"=>"10.1371/journal.pgen.1005045", "citedby-count"=>"42", "affiliation"=>[{"@_fa"=>"true", "affilname"=>"Cornell University", "affiliation-city"=>"Ithaca", "affiliation-country"=>"United States"}], "pubmed-id"=>"25764179", "prism:aggregationType"=>"Journal", "subtype"=>"ar", "subtypeDescription"=>"Article", "article-number"=>"e1005045", "source-id"=>"4000151808", "openaccess"=>"1", "openaccessFlag"=>true}

Facebook

  • {"url"=>"http%3A%2F%2Fjournals.plos.org%2Fplosgenetics%2Farticle%3Fid%3D10.1371%252Fjournal.pgen.1005045", "share_count"=>2, "like_count"=>89, "comment_count"=>24, "click_count"=>0, "total_count"=>115}

Counter

  • {"month"=>"3", "year"=>"2015", "pdf_views"=>"93", "xml_views"=>"6", "html_views"=>"844"}
  • {"month"=>"4", "year"=>"2015", "pdf_views"=>"42", "xml_views"=>"4", "html_views"=>"363"}
  • {"month"=>"5", "year"=>"2015", "pdf_views"=>"41", "xml_views"=>"0", "html_views"=>"150"}
  • {"month"=>"6", "year"=>"2015", "pdf_views"=>"36", "xml_views"=>"0", "html_views"=>"124"}
  • {"month"=>"7", "year"=>"2015", "pdf_views"=>"22", "xml_views"=>"0", "html_views"=>"73"}
  • {"month"=>"8", "year"=>"2015", "pdf_views"=>"19", "xml_views"=>"0", "html_views"=>"101"}
  • {"month"=>"9", "year"=>"2015", "pdf_views"=>"24", "xml_views"=>"1", "html_views"=>"78"}
  • {"month"=>"10", "year"=>"2015", "pdf_views"=>"30", "xml_views"=>"0", "html_views"=>"113"}
  • {"month"=>"11", "year"=>"2015", "pdf_views"=>"40", "xml_views"=>"1", "html_views"=>"123"}
  • {"month"=>"12", "year"=>"2015", "pdf_views"=>"20", "xml_views"=>"0", "html_views"=>"85"}
  • {"month"=>"1", "year"=>"2016", "pdf_views"=>"16", "xml_views"=>"0", "html_views"=>"85"}
  • {"month"=>"2", "year"=>"2016", "pdf_views"=>"39", "xml_views"=>"1", "html_views"=>"98"}
  • {"month"=>"3", "year"=>"2016", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"94"}
  • {"month"=>"4", "year"=>"2016", "pdf_views"=>"33", "xml_views"=>"0", "html_views"=>"81"}
  • {"month"=>"5", "year"=>"2016", "pdf_views"=>"14", "xml_views"=>"0", "html_views"=>"38"}
  • {"month"=>"6", "year"=>"2016", "pdf_views"=>"14", "xml_views"=>"0", "html_views"=>"68"}
  • {"month"=>"7", "year"=>"2016", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"42"}
  • {"month"=>"8", "year"=>"2016", "pdf_views"=>"16", "xml_views"=>"0", "html_views"=>"80"}
  • {"month"=>"9", "year"=>"2016", "pdf_views"=>"25", "xml_views"=>"0", "html_views"=>"61"}
  • {"month"=>"10", "year"=>"2016", "pdf_views"=>"24", "xml_views"=>"0", "html_views"=>"73"}
  • {"month"=>"11", "year"=>"2016", "pdf_views"=>"12", "xml_views"=>"1", "html_views"=>"68"}
  • {"month"=>"12", "year"=>"2016", "pdf_views"=>"35", "xml_views"=>"0", "html_views"=>"67"}
  • {"month"=>"1", "year"=>"2017", "pdf_views"=>"14", "xml_views"=>"0", "html_views"=>"64"}
  • {"month"=>"2", "year"=>"2017", "pdf_views"=>"25", "xml_views"=>"0", "html_views"=>"75"}
  • {"month"=>"3", "year"=>"2017", "pdf_views"=>"23", "xml_views"=>"0", "html_views"=>"77"}
  • {"month"=>"4", "year"=>"2017", "pdf_views"=>"22", "xml_views"=>"1", "html_views"=>"95"}
  • {"month"=>"5", "year"=>"2017", "pdf_views"=>"19", "xml_views"=>"0", "html_views"=>"69"}
  • {"month"=>"6", "year"=>"2017", "pdf_views"=>"22", "xml_views"=>"0", "html_views"=>"78"}
  • {"month"=>"7", "year"=>"2017", "pdf_views"=>"16", "xml_views"=>"0", "html_views"=>"61"}
  • {"month"=>"8", "year"=>"2017", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"37"}
  • {"month"=>"9", "year"=>"2017", "pdf_views"=>"13", "xml_views"=>"1", "html_views"=>"47"}
  • {"month"=>"10", "year"=>"2017", "pdf_views"=>"17", "xml_views"=>"3", "html_views"=>"52"}
  • {"month"=>"11", "year"=>"2017", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"98"}
  • {"month"=>"12", "year"=>"2017", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"50"}
  • {"month"=>"1", "year"=>"2018", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"49"}
  • {"month"=>"2", "year"=>"2018", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"37"}
  • {"month"=>"3", "year"=>"2018", "pdf_views"=>"23", "xml_views"=>"0", "html_views"=>"42"}
  • {"month"=>"4", "year"=>"2018", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"35"}
  • {"month"=>"5", "year"=>"2018", "pdf_views"=>"24", "xml_views"=>"0", "html_views"=>"56"}
  • {"month"=>"6", "year"=>"2018", "pdf_views"=>"18", "xml_views"=>"1", "html_views"=>"23"}
  • {"month"=>"7", "year"=>"2018", "pdf_views"=>"22", "xml_views"=>"3", "html_views"=>"28"}
  • {"month"=>"8", "year"=>"2018", "pdf_views"=>"9", "xml_views"=>"2", "html_views"=>"24"}
  • {"month"=>"9", "year"=>"2018", "pdf_views"=>"11", "xml_views"=>"1", "html_views"=>"17"}
  • {"month"=>"10", "year"=>"2018", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"25"}
  • {"month"=>"11", "year"=>"2018", "pdf_views"=>"15", "xml_views"=>"1", "html_views"=>"34"}
  • {"month"=>"12", "year"=>"2018", "pdf_views"=>"16", "xml_views"=>"1", "html_views"=>"37"}
  • {"month"=>"1", "year"=>"2019", "pdf_views"=>"25", "xml_views"=>"0", "html_views"=>"20"}
  • {"month"=>"2", "year"=>"2019", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"15"}
  • {"month"=>"3", "year"=>"2019", "pdf_views"=>"24", "xml_views"=>"1", "html_views"=>"26"}
  • {"month"=>"4", "year"=>"2019", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"17"}
  • {"month"=>"5", "year"=>"2019", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"13"}
  • {"month"=>"6", "year"=>"2019", "pdf_views"=>"19", "xml_views"=>"0", "html_views"=>"21"}
  • {"month"=>"7", "year"=>"2019", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"15"}
  • {"month"=>"8", "year"=>"2019", "pdf_views"=>"6", "xml_views"=>"1", "html_views"=>"14"}
  • {"month"=>"9", "year"=>"2019", "pdf_views"=>"25", "xml_views"=>"0", "html_views"=>"28"}
  • {"month"=>"10", "year"=>"2019", "pdf_views"=>"21", "xml_views"=>"0", "html_views"=>"27"}
  • {"month"=>"11", "year"=>"2019", "pdf_views"=>"45", "xml_views"=>"2", "html_views"=>"43"}
  • {"month"=>"12", "year"=>"2019", "pdf_views"=>"12", "xml_views"=>"3", "html_views"=>"20"}
  • {"month"=>"1", "year"=>"2020", "pdf_views"=>"22", "xml_views"=>"3", "html_views"=>"19"}
  • {"month"=>"2", "year"=>"2020", "pdf_views"=>"9", "xml_views"=>"2", "html_views"=>"46"}
  • {"month"=>"3", "year"=>"2020", "pdf_views"=>"8", "xml_views"=>"1", "html_views"=>"21"}
  • {"month"=>"4", "year"=>"2020", "pdf_views"=>"20", "xml_views"=>"0", "html_views"=>"22"}
  • {"month"=>"5", "year"=>"2020", "pdf_views"=>"16", "xml_views"=>"0", "html_views"=>"17"}
  • {"month"=>"6", "year"=>"2020", "pdf_views"=>"16", "xml_views"=>"3", "html_views"=>"15"}
  • {"month"=>"7", "year"=>"2020", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"19"}
  • {"month"=>"8", "year"=>"2020", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"0"}

Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/1946333"], "description"=>"<p>Significant GWAS hits were functionally annotated using basic local alignment search tool. These annotations were categorized into biological groups, which include: structural components, secondary metabolites, primary metabolites, genes previously implicated in pathogen-defense, membrane transporter, development, cellular energy, cell signaling, and cell cycle. The genes on the inter-pro hit list (<a href=\"http://www.maizesequence.org\" target=\"_blank\">www.maizesequence.org</a>) were also categorized into these same categories. The genome count indicates the total number of genes within the genome in the given category, and the GLS (Count) indicates the number of annotated GLS GWAS hits in a given category. A proportion z-test was used to test the abundance of genes in a given category relative to the overall abundance predicted in the maize genome. SE: standard error.</p><p>Summary statistics of functionally annotated and categorized genome wide association hits.</p>", "links"=>[], "tags"=>["resistance", "nam", "B 73 reference allele", "qGLS 1.04", "Nested Association Mapping", "mb", "gene", "Gray Leaf Spot", "qtl", "fmo", "qGLS 4.05. NILs", "loci", "QDR"], "article_id"=>1333920, "categories"=>["Biological Sciences"], "users"=>["Jacqueline M. Benson", "Jesse A. Poland", "Brent M. Benson", "Erik L. Stromberg", "Rebecca J. Nelson"], "doi"=>"https://dx.doi.org/10.1371/journal.pgen.1005045.t003", "stats"=>{"downloads"=>4, "page_views"=>21, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Summary_statistics_of_functionally_annotated_and_categorized_genome_wide_association_hits_/1333920", "title"=>"Summary statistics of functionally annotated and categorized genome wide association hits.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-03-12 03:09:56"}
  • {"files"=>["https://ndownloader.figshare.com/files/1946331"], "description"=>"<p>Descriptive statistics for area under the disease progress curve within the nested association mapping sub-populations (sub-population is indicated by the non-B73 parent) and among the parental lines.</p><p>SE = Standard Error</p><p>SD = Standard Deviation</p><p>V = Variance</p><p>Min = minimum</p><p>Max = maximum</p><p>AUDPC summary statistics for the nested association mapping population.</p>", "links"=>[], "tags"=>["resistance", "nam", "B 73 reference allele", "qGLS 1.04", "Nested Association Mapping", "mb", "gene", "Gray Leaf Spot", "qtl", "fmo", "qGLS 4.05. NILs", "loci", "QDR"], "article_id"=>1333918, "categories"=>["Biological Sciences"], "users"=>["Jacqueline M. Benson", "Jesse A. Poland", "Brent M. Benson", "Erik L. Stromberg", "Rebecca J. Nelson"], "doi"=>"https://dx.doi.org/10.1371/journal.pgen.1005045.t001", "stats"=>{"downloads"=>4, "page_views"=>81, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_AUDPC_summary_statistics_for_the_nested_association_mapping_population_/1333918", "title"=>"AUDPC summary statistics for the nested association mapping population.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-03-12 03:09:56"}
  • {"files"=>["https://ndownloader.figshare.com/files/1946328"], "description"=>"<p>Expression differences were detected for the putative flavin-monooxygenase among heterogeneous inbred family lines segregating at <i>qGLS1.04</i> for the B73 or CML228 maize alleles. The heterogenous inbred family lines were treated with cercosporin or the acetone control on either side of the maize leaf midrib. There was a significant difference between the CML228 samples treated with cercosporin and the other samples in the experiment (<i>p</i> = 0.0012).</p>", "links"=>[], "tags"=>["resistance", "nam", "B 73 reference allele", "qGLS 1.04", "Nested Association Mapping", "mb", "gene", "Gray Leaf Spot", "qtl", "fmo", "qGLS 4.05. NILs", "loci", "QDR"], "article_id"=>1333915, "categories"=>["Biological Sciences"], "users"=>["Jacqueline M. Benson", "Jesse A. Poland", "Brent M. Benson", "Erik L. Stromberg", "Rebecca J. Nelson"], "doi"=>"https://dx.doi.org/10.1371/journal.pgen.1005045.g005", "stats"=>{"downloads"=>1, "page_views"=>12, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Analysis_of_flavin_monooxygenase_expression_at_qGLS1_04_/1333915", "title"=>"Analysis of flavin-monooxygenase expression at qGLS1.04.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-03-12 03:09:56"}
  • {"files"=>["https://ndownloader.figshare.com/files/1946327"], "description"=>"<p>Effect sizes of QTL for gray leaf spot, northern leaf blight, southern leaf blight and Blacksburg specific days to anthesis were significantly different (<i>p</i> = 6.33x10<sup>–30</sup>).</p>", "links"=>[], "tags"=>["resistance", "nam", "B 73 reference allele", "qGLS 1.04", "Nested Association Mapping", "mb", "gene", "Gray Leaf Spot", "qtl", "fmo", "qGLS 4.05. NILs", "loci", "QDR"], "article_id"=>1333914, "categories"=>["Biological Sciences"], "users"=>["Jacqueline M. Benson", "Jesse A. Poland", "Brent M. Benson", "Erik L. Stromberg", "Rebecca J. Nelson"], "doi"=>"https://dx.doi.org/10.1371/journal.pgen.1005045.g004", "stats"=>{"downloads"=>1, "page_views"=>2, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Absolute_value_of_quantitative_trait_loci_QTL_effect_size_across_three_diseases_and_flowering_time_/1333914", "title"=>"Absolute value of quantitative trait loci (QTL) effect size across three diseases and flowering time.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-03-12 03:09:56"}
  • {"files"=>["https://ndownloader.figshare.com/files/1946336"], "description"=>"<p>IVD = intervein distance</p><p>DF = degrees of freedom</p><p>Prob = probability</p><p>SS = sum of squares</p><p>TSS = total sum of squares.</p><p>Model results with conidiophore count (square root) as the response variable and lesion parameter predictors.</p>", "links"=>[], "tags"=>["resistance", "nam", "B 73 reference allele", "qGLS 1.04", "Nested Association Mapping", "mb", "gene", "Gray Leaf Spot", "qtl", "fmo", "qGLS 4.05. NILs", "loci", "QDR"], "article_id"=>1333923, "categories"=>["Biological Sciences"], "users"=>["Jacqueline M. Benson", "Jesse A. Poland", "Brent M. Benson", "Erik L. Stromberg", "Rebecca J. Nelson"], "doi"=>"https://dx.doi.org/10.1371/journal.pgen.1005045.t006", "stats"=>{"downloads"=>1, "page_views"=>17, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Model_results_with_conidiophore_count_square_root_as_the_response_variable_and_lesion_parameter_predictors_/1333923", "title"=>"Model results with conidiophore count (square root) as the response variable and lesion parameter predictors.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-03-12 03:09:56"}
  • {"files"=>["https://ndownloader.figshare.com/files/1946335"], "description"=>"<p>Summary statistics for functionally annotated and categorized genes within the qGLS1.04 quantitative trait loci hypothesized as putative detoxification-related genes.</p><p>SE = standard error.</p><p>Summary statistics for detoxification-related genes underlying qGLS1.04.</p>", "links"=>[], "tags"=>["resistance", "nam", "B 73 reference allele", "qGLS 1.04", "Nested Association Mapping", "mb", "gene", "Gray Leaf Spot", "qtl", "fmo", "qGLS 4.05. NILs", "loci", "QDR"], "article_id"=>1333922, "categories"=>["Biological Sciences"], "users"=>["Jacqueline M. Benson", "Jesse A. Poland", "Brent M. Benson", "Erik L. Stromberg", "Rebecca J. Nelson"], "doi"=>"https://dx.doi.org/10.1371/journal.pgen.1005045.t005", "stats"=>{"downloads"=>1, "page_views"=>16, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Summary_statistics_for_detoxification_related_genes_underlying_qGLS1_04_/1333922", "title"=>"Summary statistics for detoxification-related genes underlying qGLS1.04.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-03-12 03:09:56"}
  • {"files"=>["https://ndownloader.figshare.com/files/1946330"], "description"=>"<p>Significant relationship was detected between inter-vein distance and square root (sqrt) of the conidiophore counts (<i>r</i><sup><i>2</i></sup> = 0.43; <i>p</i><0.0001).</p>", "links"=>[], "tags"=>["resistance", "nam", "B 73 reference allele", "qGLS 1.04", "Nested Association Mapping", "mb", "gene", "Gray Leaf Spot", "qtl", "fmo", "qGLS 4.05. NILs", "loci", "QDR"], "article_id"=>1333917, "categories"=>["Biological Sciences"], "users"=>["Jacqueline M. Benson", "Jesse A. Poland", "Brent M. Benson", "Erik L. Stromberg", "Rebecca J. Nelson"], "doi"=>"https://dx.doi.org/10.1371/journal.pgen.1005045.g007", "stats"=>{"downloads"=>3, "page_views"=>21, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Relationship_between_conidiophore_count_and_intervein_distance_/1333917", "title"=>"Relationship between conidiophore count and intervein distance.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-03-12 03:09:56"}
  • {"files"=>["https://ndownloader.figshare.com/files/1946329"], "description"=>"<p>Quantitative trait loci for GLS and inter-vein distance (IVD) are indicated. Circles designate co-localizing areas. Scanned leaf images (upper-right corner) demonstrate the difference between IVD from maize leaves with B73 and KI11 alleles at <i>qGLS4.05</i>.</p>", "links"=>[], "tags"=>["resistance", "nam", "B 73 reference allele", "qGLS 1.04", "Nested Association Mapping", "mb", "gene", "Gray Leaf Spot", "qtl", "fmo", "qGLS 4.05. NILs", "loci", "QDR"], "article_id"=>1333916, "categories"=>["Biological Sciences"], "users"=>["Jacqueline M. Benson", "Jesse A. Poland", "Brent M. Benson", "Erik L. Stromberg", "Rebecca J. Nelson"], "doi"=>"https://dx.doi.org/10.1371/journal.pgen.1005045.g006", "stats"=>{"downloads"=>2, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Gray_leaf_spot_GLS_and_venation_quantitative_trait_loci_/1333916", "title"=>"Gray leaf spot (GLS) and venation quantitative trait loci.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-03-12 03:09:56"}
  • {"files"=>["https://ndownloader.figshare.com/files/1946326"], "description"=>"<p>Disease development [area under the disease progress curve (AUDPC)]is indicated among heterogeneous inbred family lines across three gray leaf spot quantitative trait loci.</p>", "links"=>[], "tags"=>["resistance", "nam", "B 73 reference allele", "qGLS 1.04", "Nested Association Mapping", "mb", "gene", "Gray Leaf Spot", "qtl", "fmo", "qGLS 4.05. NILs", "loci", "QDR"], "article_id"=>1333913, "categories"=>["Biological Sciences"], "users"=>["Jacqueline M. Benson", "Jesse A. Poland", "Brent M. Benson", "Erik L. Stromberg", "Rebecca J. Nelson"], "doi"=>"https://dx.doi.org/10.1371/journal.pgen.1005045.g003", "stats"=>{"downloads"=>1, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Confirmation_of_three_disease_quantitative_trait_loci_using_near_isogenic_lines_/1333913", "title"=>"Confirmation of three disease quantitative trait loci using near isogenic lines.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-03-12 03:09:56"}
  • {"files"=>["https://ndownloader.figshare.com/files/1946324"], "description"=>"<p>The bin number is listed in the respective column header between the first and last columns. Two sets of data are presented in this figure. Estimated allelic effects relative to the B73 allele of parental lines at <i>qGLSbin</i> for relative change in disease are listed. The values in the table are the coefficients of the general linear model parameter while the color coding is indicative of area under the disease progress curve. R = resistant; S = susceptible.</p>", "links"=>[], "tags"=>["resistance", "nam", "B 73 reference allele", "qGLS 1.04", "Nested Association Mapping", "mb", "gene", "Gray Leaf Spot", "qtl", "fmo", "qGLS 4.05. NILs", "loci", "QDR"], "article_id"=>1333911, "categories"=>["Biological Sciences"], "users"=>["Jacqueline M. Benson", "Jesse A. Poland", "Brent M. Benson", "Erik L. Stromberg", "Rebecca J. Nelson"], "doi"=>"https://dx.doi.org/10.1371/journal.pgen.1005045.g001", "stats"=>{"downloads"=>1, "page_views"=>2, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Parental_allelic_effects_at_quantitative_trait_loci_/1333911", "title"=>"Parental allelic effects at quantitative trait loci.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-03-12 03:09:56"}
  • {"files"=>["https://ndownloader.figshare.com/files/1946325"], "description"=>"<p>Each circle indicates the predicted change in disease of a single allele. There are 26 circles for each QTL, each representating the allele from one of the nested association mapping parental sources.</p>", "links"=>[], "tags"=>["resistance", "nam", "B 73 reference allele", "qGLS 1.04", "Nested Association Mapping", "mb", "gene", "Gray Leaf Spot", "qtl", "fmo", "qGLS 4.05. NILs", "loci", "QDR"], "article_id"=>1333912, "categories"=>["Biological Sciences"], "users"=>["Jacqueline M. Benson", "Jesse A. Poland", "Brent M. Benson", "Erik L. Stromberg", "Rebecca J. Nelson"], "doi"=>"https://dx.doi.org/10.1371/journal.pgen.1005045.g002", "stats"=>{"downloads"=>1, "page_views"=>10, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_General_linear_model_predicted_percent_change_in_disease_across_significant_disease_quantitative_trait_loci_QTL_/1333912", "title"=>"General linear model predicted percent change in disease across significant disease quantitative trait loci (QTL).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2015-03-12 03:09:56"}
  • {"files"=>["https://ndownloader.figshare.com/files/1946337", "https://ndownloader.figshare.com/files/1946338", "https://ndownloader.figshare.com/files/1946339", "https://ndownloader.figshare.com/files/1946340", "https://ndownloader.figshare.com/files/1946341", "https://ndownloader.figshare.com/files/1946342", "https://ndownloader.figshare.com/files/1946343", "https://ndownloader.figshare.com/files/1946344", "https://ndownloader.figshare.com/files/1946345", "https://ndownloader.figshare.com/files/1946346", "https://ndownloader.figshare.com/files/1946347"], "description"=>"<div><p>Gray leaf spot (GLS), caused by <i>Cercospora zeae-maydis</i> and <i>Cercospora zeina</i>, is one of the most important diseases of maize worldwide. The pathogen has a necrotrophic lifestyle and no major genes are known for GLS. Quantitative resistance, although poorly understood, is important for GLS management. We used genetic mapping to refine understanding of the genetic architecture of GLS resistance and to develop hypotheses regarding the mechanisms underlying quantitative disease resistance (QDR) loci. Nested association mapping (NAM) was used to identify 16 quantitative trait loci (QTL) for QDR to GLS, including seven novel QTL, each of which demonstrated allelic series with significant effects above and below the magnitude of the B73 reference allele. Alleles at three QTL, <i>qGLS1.04</i>, <i>qGLS2.09</i>, and <i>qGLS4.05</i>, conferred disease reductions of greater than 10%. Interactions between loci were detected for three pairs of loci, including an interaction between <i>iqGLS4.05</i> and <i>qGLS7.03</i>. Near-isogenic lines (NILs) were developed to confirm and fine-map three of the 16 QTL, and to develop hypotheses regarding mechanisms of resistance. <i>qGLS1.04</i> was fine-mapped from an interval of 27.0 Mb to two intervals of 6.5 Mb and 5.2 Mb, consistent with the hypothesis that multiple genes underlie highly significant QTL identified by NAM. <i>qGLS2.09</i>, which was also associated with maturity (days to anthesis) and with resistance to southern leaf blight, was narrowed to a 4-Mb interval. The distance between major leaf veins was strongly associated with resistance to GLS at <i>qGLS4.05</i>. NILs for <i>qGLS1.04</i> were treated with the <i>C</i>. <i>zeae-maydis</i> toxin cercosporin to test the role of host-specific toxin in QDR. Cercosporin exposure increased expression of a putative flavin-monooxygenase (FMO) gene, a candidate detoxification-related gene underlying <i>qGLS1.04</i>. This integrated approach to confirming QTL and characterizing the potential underlying mechanisms advances the understanding of QDR and will facilitate the development of resistant varieties.</p></div>", "links"=>[], "tags"=>["resistance", "nam", "B 73 reference allele", "qGLS 1.04", "Nested Association Mapping", "mb", "gene", "Gray Leaf Spot", "qtl", "fmo", "qGLS 4.05. NILs", "loci", "QDR"], "article_id"=>1333924, "categories"=>["Biological Sciences"], "users"=>["Jacqueline M. Benson", "Jesse A. Poland", "Brent M. Benson", "Erik L. Stromberg", "Rebecca J. Nelson"], "doi"=>["https://dx.doi.org/10.1371/journal.pgen.1005045.s001", "https://dx.doi.org/10.1371/journal.pgen.1005045.s002", "https://dx.doi.org/10.1371/journal.pgen.1005045.s003", "https://dx.doi.org/10.1371/journal.pgen.1005045.s004", "https://dx.doi.org/10.1371/journal.pgen.1005045.s005", "https://dx.doi.org/10.1371/journal.pgen.1005045.s006", "https://dx.doi.org/10.1371/journal.pgen.1005045.s007", "https://dx.doi.org/10.1371/journal.pgen.1005045.s008", "https://dx.doi.org/10.1371/journal.pgen.1005045.s009", "https://dx.doi.org/10.1371/journal.pgen.1005045.s010", "https://dx.doi.org/10.1371/journal.pgen.1005045.s011"], "stats"=>{"downloads"=>31, "page_views"=>13, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Resistance_to_Gray_Leaf_Spot_of_Maize_Genetic_Architecture_and_Mechanisms_Elucidated_through_Nested_Association_Mapping_and_Near_Isogenic_Line_Analysis_/1333924", "title"=>"Resistance to Gray Leaf Spot of Maize: Genetic Architecture and Mechanisms Elucidated through Nested Association Mapping and Near-Isogenic Line Analysis", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2015-03-12 03:09:56"}
  • {"files"=>["https://ndownloader.figshare.com/files/1946334"], "description"=>"<p>Markers and associated p-values from the qGLS1.04 fine-mapping analysis.</p>", "links"=>[], "tags"=>["resistance", "nam", "B 73 reference allele", "qGLS 1.04", "Nested Association Mapping", "mb", "gene", "Gray Leaf Spot", "qtl", "fmo", "qGLS 4.05. NILs", "loci", "QDR"], "article_id"=>1333921, "categories"=>["Biological Sciences"], "users"=>["Jacqueline M. Benson", "Jesse A. Poland", "Brent M. Benson", "Erik L. Stromberg", "Rebecca J. Nelson"], "doi"=>"https://dx.doi.org/10.1371/journal.pgen.1005045.t004", "stats"=>{"downloads"=>3, "page_views"=>14, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Markers_and_associated_p_values_from_the_qGLS1_04_fine_mapping_analysis_/1333921", "title"=>"Markers and associated p-values from the qGLS1.04 fine-mapping analysis.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-03-12 03:09:56"}
  • {"files"=>["https://ndownloader.figshare.com/files/1946332"], "description"=>"<p>Quantitative trait loci (QTL) were identified by nested association mapping of GLS resistance. Model selection results are given in relation to the co-localizing QTL associated with previously published studies. <i>p</i><0.0001, Chr = Chromosome</p><p>CI = Confidence Interval</p><p>DTA = Blacksburg (Whitethorne Farms)-specific days to anthesis</p><p>Southern Leaf Blight (SLB) QTL Source: [<a href=\"http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1005045#pgen.1005045.ref046\" target=\"_blank\">46</a>]</p><p>Northern Leaf Blight (NLB) QTL Source: [<a href=\"http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1005045#pgen.1005045.ref040\" target=\"_blank\">40</a>]</p><p>Asterisks indicate better resolved QTL</p><p>double asterisks denote QTL reported here for the first time</p><p><sup>+,-</sup> indicates significant positive, negative association of allelic effects, respectively.</p><p>Summary of resistance to gray leaf spot (GLS) in the nested association mapping population.</p>", "links"=>[], "tags"=>["resistance", "nam", "B 73 reference allele", "qGLS 1.04", "Nested Association Mapping", "mb", "gene", "Gray Leaf Spot", "qtl", "fmo", "qGLS 4.05. NILs", "loci", "QDR"], "article_id"=>1333919, "categories"=>["Biological Sciences"], "users"=>["Jacqueline M. Benson", "Jesse A. Poland", "Brent M. Benson", "Erik L. Stromberg", "Rebecca J. Nelson"], "doi"=>"https://dx.doi.org/10.1371/journal.pgen.1005045.t002", "stats"=>{"downloads"=>12, "page_views"=>15, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Summary_of_resistance_to_gray_leaf_spot_GLS_in_the_nested_association_mapping_population_/1333919", "title"=>"Summary of resistance to gray leaf spot (GLS) in the nested association mapping population.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2015-03-12 03:09:56"}

PMC Usage Stats | Further Information

  • {"unique-ip"=>"9", "full-text"=>"8", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"3"}
  • {"unique-ip"=>"19", "full-text"=>"11", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2015", "month"=>"4"}
  • {"unique-ip"=>"32", "full-text"=>"37", "pdf"=>"25", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"12", "cited-by"=>"0", "year"=>"2015", "month"=>"5"}
  • {"unique-ip"=>"22", "full-text"=>"17", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2015", "month"=>"6"}
  • {"unique-ip"=>"32", "full-text"=>"36", "pdf"=>"10", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"7"}
  • {"unique-ip"=>"19", "full-text"=>"21", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"8"}
  • {"unique-ip"=>"57", "full-text"=>"37", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"10", "supp-data"=>"11", "cited-by"=>"1", "year"=>"2015", "month"=>"9"}
  • {"unique-ip"=>"34", "full-text"=>"33", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2015", "month"=>"10"}
  • {"unique-ip"=>"43", "full-text"=>"36", "pdf"=>"20", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"2", "year"=>"2015", "month"=>"11"}
  • {"unique-ip"=>"48", "full-text"=>"48", "pdf"=>"19", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"16", "cited-by"=>"0", "year"=>"2015", "month"=>"12"}
  • {"unique-ip"=>"33", "full-text"=>"32", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"11", "supp-data"=>"2", "cited-by"=>"1", "year"=>"2016", "month"=>"1"}
  • {"unique-ip"=>"31", "full-text"=>"36", "pdf"=>"11", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"2"}
  • {"unique-ip"=>"55", "full-text"=>"76", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"19", "cited-by"=>"0", "year"=>"2016", "month"=>"3"}
  • {"unique-ip"=>"35", "full-text"=>"44", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"4"}
  • {"unique-ip"=>"33", "full-text"=>"32", "pdf"=>"12", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2016", "month"=>"5"}
  • {"unique-ip"=>"23", "full-text"=>"23", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"6"}
  • {"unique-ip"=>"28", "full-text"=>"28", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"7"}
  • {"unique-ip"=>"24", "full-text"=>"23", "pdf"=>"10", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"4", "cited-by"=>"0", "year"=>"2016", "month"=>"8"}
  • {"unique-ip"=>"23", "full-text"=>"29", "pdf"=>"11", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"9"}
  • {"unique-ip"=>"28", "full-text"=>"29", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2016", "month"=>"10"}
  • {"unique-ip"=>"25", "full-text"=>"31", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"15", "cited-by"=>"0", "year"=>"2016", "month"=>"11"}
  • {"unique-ip"=>"24", "full-text"=>"26", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"12"}
  • {"unique-ip"=>"18", "full-text"=>"17", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"1"}
  • {"unique-ip"=>"13", "full-text"=>"21", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"2"}
  • {"unique-ip"=>"27", "full-text"=>"52", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2017", "month"=>"3"}
  • {"unique-ip"=>"20", "full-text"=>"36", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2017", "month"=>"4"}
  • {"unique-ip"=>"28", "full-text"=>"33", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"5"}
  • {"unique-ip"=>"14", "full-text"=>"18", "pdf"=>"11", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"6"}
  • {"unique-ip"=>"13", "full-text"=>"15", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"7"}
  • {"unique-ip"=>"19", "full-text"=>"21", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"8"}
  • {"unique-ip"=>"36", "full-text"=>"25", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"9"}
  • {"unique-ip"=>"22", "full-text"=>"19", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"10"}
  • {"unique-ip"=>"10", "full-text"=>"11", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"11"}
  • {"unique-ip"=>"20", "full-text"=>"17", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"12"}
  • {"unique-ip"=>"8", "full-text"=>"10", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"1"}
  • {"unique-ip"=>"20", "full-text"=>"19", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"3"}
  • {"unique-ip"=>"11", "full-text"=>"14", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"1"}
  • {"unique-ip"=>"15", "full-text"=>"18", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"4"}
  • {"unique-ip"=>"17", "full-text"=>"17", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"5"}
  • {"unique-ip"=>"13", "full-text"=>"11", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"6"}
  • {"unique-ip"=>"13", "full-text"=>"10", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"4", "cited-by"=>"0", "year"=>"2018", "month"=>"7"}
  • {"unique-ip"=>"6", "full-text"=>"7", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"8"}
  • {"unique-ip"=>"6", "full-text"=>"8", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"9"}
  • {"unique-ip"=>"27", "full-text"=>"22", "pdf"=>"7", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"10"}
  • {"unique-ip"=>"12", "full-text"=>"15", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2018", "month"=>"11"}
  • {"unique-ip"=>"12", "full-text"=>"14", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"12"}
  • {"unique-ip"=>"16", "full-text"=>"20", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"2"}
  • {"unique-ip"=>"20", "full-text"=>"22", "pdf"=>"7", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"3"}
  • {"unique-ip"=>"19", "full-text"=>"27", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"4"}
  • {"unique-ip"=>"19", "full-text"=>"24", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"5"}
  • {"unique-ip"=>"16", "full-text"=>"14", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"8"}
  • {"unique-ip"=>"29", "full-text"=>"31", "pdf"=>"6", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"9"}
  • {"unique-ip"=>"33", "full-text"=>"35", "pdf"=>"10", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"11", "cited-by"=>"0", "year"=>"2019", "month"=>"10"}
  • {"unique-ip"=>"24", "full-text"=>"22", "pdf"=>"8", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"12"}
  • {"unique-ip"=>"20", "full-text"=>"23", "pdf"=>"7", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"1", "year"=>"2020", "month"=>"2"}
  • {"unique-ip"=>"38", "full-text"=>"37", "pdf"=>"12", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"3"}
  • {"unique-ip"=>"27", "full-text"=>"37", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"4"}
  • {"unique-ip"=>"25", "full-text"=>"23", "pdf"=>"6", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2020", "month"=>"5"}
  • {"unique-ip"=>"20", "full-text"=>"16", "pdf"=>"6", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"11", "cited-by"=>"0", "year"=>"2020", "month"=>"6"}

Relative Metric

{"start_date"=>"2015-01-01T00:00:00Z", "end_date"=>"2015-12-31T00:00:00Z", "subject_areas"=>[]}
Loading … Spinner
There are currently no alerts