Identification of Multiple Loci Associated with Social Parasitism in Honeybees
Publication Date
June 09, 2016
Journal
PLOS Genetics
Authors
Andreas Wallberg, Christian W. Pirk, Mike H. Allsopp & Matthew T. Webster
Volume
12
Issue
6
Pages
e1006097
DOI
https://dx.plos.org/10.1371/journal.pgen.1006097
Publisher URL
http://journals.plos.org/plosgenetics/article?id=10.1371%2Fjournal.pgen.1006097
Web of Science
000379347100017
Scopus
84977597655
Mendeley
http://www.mendeley.com/research/identification-multiple-loci-associated-social-parasitism-honeybees
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Mendeley | Further Information

{"title"=>"Identification of Multiple Loci Associated with Social Parasitism in Honeybees", "type"=>"journal", "authors"=>[{"first_name"=>"Andreas", "last_name"=>"Wallberg", "scopus_author_id"=>"36912240600"}, {"first_name"=>"Christian W.", "last_name"=>"Pirk", "scopus_author_id"=>"6603017163"}, {"first_name"=>"Mike H.", "last_name"=>"Allsopp", "scopus_author_id"=>"7004863984"}, {"first_name"=>"Matthew T.", "last_name"=>"Webster", "scopus_author_id"=>"7202299046"}], "year"=>2016, "source"=>"PLoS Genetics", "identifiers"=>{"issn"=>"15537404", "pui"=>"611155964", "sgr"=>"84977597655", "scopus"=>"2-s2.0-84977597655", "doi"=>"10.1371/journal.pgen.1006097"}, "id"=>"62f83d11-c1b3-311f-b2a6-f140ec98d122", "abstract"=>"Abstract\\r\\n\\r\\nIn colonies of the honeybee Apis mellifera, the queen is usually the only reproductive female, which produces new females (queens and workers) by laying fertilized eggs. However, in one subspecies of A. mellifera, known as the Cape bee (A. m. capensis), worker bees reproduce asexually by thelytoky, an abnormal form of meiosis where two daughter nucleii fuse to form single diploid eggs, which develop into females without being fertilized. The Cape bee also exhibits a suite of phenotypes that facilitate social parasitism whereby workers lay such eggs in foreign colonies so their offspring can exploit their resources. The genetic basis of this switch to social parasitism in the Cape bee is unknown. To address this, we compared genome variation in a sample of Cape bees with other African populations. We find genetic divergence between these populations to be very low on average but identify several regions of the genome with extreme differentiation. The regions are strongly enriched for signals of selection in Cape bees, indicating that increased levels of positive selection have produced the unique set of derived phenotypic traits in this subspecies. Genetic variation within these regions allows unambiguous genetic identification of Cape bees and likely underlies the genetic basis of social parasitism. The candidate loci include genes involved in ecdysteroid signaling and juvenile hormone and dopamine biosynthesis, which may regulate worker ovary activation and others whose products localize at the centrosome and are implicated in chromosomal segregation during meiosis. Functional analysis of these loci will yield insights into the processes of reproduction and chemical signaling in both parasitic and non-parasitic populations and advance understanding of the process of normal and atypical meiosis.\\r\\nAuthor Summary\\r\\n\\r\\nHoneybee colonies are mainly composed of female worker bees that are unable to lay eggs and reproduce; a task that is performed by a single queen bee. However, in a subspecies of the Western honeybee (Apis mellifera) known as the Cape bee (A. m. capensis), worker bees can lay eggs produced by an abnormal form of meiotic cell division known as thelytoky. These eggs are produced asexually and develop into female worker bees, which are then able to reproduce in the same way and hence to propagate this trait. Cape bee workers also display a variety of characteristics that enable them to invade foreign colonies, reproduce and feed off their resources, a behavior known as social parasitism. The genetic basis of these traits is unknown. Here we compare whole genome sequences of Cape bees with other honeybee subspecies and identify the genes that likely control this reproductive strategy. Although Cape bees are extremely genetically similar to other African bees, we identify genetic variants that make it possible to unambiguously distinguish them. In contrast to previous studies, our results suggest that multiple genes are involved in social parasitism, including those involved in hormonal signaling that may cause worker bees to activate their ovaries and those involved in chromosomal segregation, which may cause the switch between normal meiosis and thelytoky. Our results give insights into how genetic variants that facilitate asexual reproduction are able to invade a sexually reproducing population.\\r\\n\\r\\n", "link"=>"http://www.mendeley.com/research/identification-multiple-loci-associated-social-parasitism-honeybees", "reader_count"=>30, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Student > Doctoral Student"=>8, "Researcher"=>5, "Student > Ph. D. Student"=>6, "Student > Postgraduate"=>2, "Student > Master"=>3, "Student > Bachelor"=>2, "Lecturer"=>1, "Lecturer > Senior Lecturer"=>1, "Professor"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Student > Doctoral Student"=>8, "Researcher"=>5, "Student > Ph. D. Student"=>6, "Student > Postgraduate"=>2, "Student > Master"=>3, "Student > Bachelor"=>2, "Lecturer"=>1, "Lecturer > Senior Lecturer"=>1, "Professor"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>2, "Biochemistry, Genetics and Molecular Biology"=>3, "Agricultural and Biological Sciences"=>25}, "reader_count_by_subdiscipline"=>{"Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>25}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>3}, "Unspecified"=>{"Unspecified"=>2}}, "reader_count_by_country"=>{"United States"=>1, "Germany"=>1}, "group_count"=>0}

Scopus | Further Information

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