Epigenome-wide Association Studies and the Interpretation of Disease -Omics
Publication Date
June 23, 2016
Journal
PLOS Genetics
Authors
Ewan Birney, George Davey Smith & John M. Greally
Volume
12
Issue
6
Pages
e1006105
DOI
https://dx.plos.org/10.1371/journal.pgen.1006105
Publisher URL
http://journals.plos.org/plosgenetics/article?id=10.1371%2Fjournal.pgen.1006105
Web of Science
000379347100024
Scopus
84977481546
Mendeley
http://www.mendeley.com/research/epigenomewide-association-studies-interpretation-disease-omics
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{"title"=>"Epigenome-wide Association Studies and the Interpretation of Disease -Omics", "type"=>"generic", "authors"=>[{"first_name"=>"Ewan", "last_name"=>"Birney", "scopus_author_id"=>"7004802904"}, {"first_name"=>"George Davey", "last_name"=>"Smith", "scopus_author_id"=>"35354080500"}, {"first_name"=>"John M.", "last_name"=>"Greally", "scopus_author_id"=>"57193194266"}], "year"=>2016, "source"=>"PLoS Genetics", "identifiers"=>{"scopus"=>"2-s2.0-84977481546", "pui"=>"611155854", "sgr"=>"84977481546", "isbn"=>"1553-7404 (Electronic)\\r1553-7390 (Linking)", "issn"=>"15537404", "pmid"=>"27336614", "doi"=>"10.1371/journal.pgen.1006105"}, "id"=>"379064c4-1c93-3ab6-a32d-7764827e4bac", "abstract"=>"Epigenome-wide association studies represent one means of applying genome-wide assays to identify molecular events that could be associated with human phenotypes. The epigenome is especially intriguing as a target for study, as epigenetic regulatory processes are, by definition, heritable from parent to daughter cells and are found to have transcriptional regulatory properties. As such, the epigenome is an attractive candidate for mediating long-term responses to cellular stimuli, such as environmental effects modifying disease risk. Such epigenomic studies represent a broader category of disease -omics, which suffer from multiple problems in design and execution that severely limit their interpretability. Here we define many of the problems with current epigenomic studies and propose solutions that can be applied to allow this and other disease -omics studies to achieve their potential for generating valuable insights.", "link"=>"http://www.mendeley.com/research/epigenomewide-association-studies-interpretation-disease-omics", "reader_count"=>314, "reader_count_by_academic_status"=>{"Unspecified"=>10, "Professor > Associate Professor"=>15, "Researcher"=>75, "Student > Doctoral Student"=>14, "Student > Ph. D. Student"=>72, "Student > Postgraduate"=>34, "Student > Master"=>25, "Other"=>15, "Student > Bachelor"=>27, "Lecturer"=>5, "Lecturer > Senior Lecturer"=>5, "Professor"=>17}, "reader_count_by_user_role"=>{"Unspecified"=>10, "Professor > Associate Professor"=>15, "Researcher"=>75, "Student > Doctoral Student"=>14, "Student > Ph. D. Student"=>72, "Student > Postgraduate"=>34, "Student > Master"=>25, "Other"=>15, "Student > Bachelor"=>27, "Lecturer"=>5, "Lecturer > Senior Lecturer"=>5, "Professor"=>17}, "reader_count_by_subject_area"=>{"Unspecified"=>17, "Agricultural and Biological Sciences"=>129, "Philosophy"=>2, "Arts and Humanities"=>1, "Business, Management and Accounting"=>1, "Computer Science"=>7, "Economics, Econometrics and Finance"=>3, "Engineering"=>3, "Environmental Science"=>2, "Biochemistry, Genetics and Molecular Biology"=>92, "Medicine and Dentistry"=>26, "Neuroscience"=>4, "Pharmacology, Toxicology and Pharmaceutical Science"=>1, "Physics and Astronomy"=>1, "Psychology"=>13, "Social Sciences"=>6, "Immunology and Microbiology"=>5, "Linguistics"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>26}, "Social Sciences"=>{"Social Sciences"=>6}, "Physics and Astronomy"=>{"Physics and Astronomy"=>1}, "Psychology"=>{"Psychology"=>13}, "Unspecified"=>{"Unspecified"=>17}, "Environmental Science"=>{"Environmental Science"=>2}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>1}, "Arts and Humanities"=>{"Arts and Humanities"=>1}, "Engineering"=>{"Engineering"=>3}, "Neuroscience"=>{"Neuroscience"=>4}, "Economics, Econometrics and Finance"=>{"Economics, Econometrics and Finance"=>3}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>5}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>129}, "Computer Science"=>{"Computer Science"=>7}, "Business, Management and Accounting"=>{"Business, Management and Accounting"=>1}, "Linguistics"=>{"Linguistics"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>92}, "Philosophy"=>{"Philosophy"=>2}}, "reader_count_by_country"=>{"United States"=>7, "Japan"=>1, "United Kingdom"=>3, "Switzerland"=>1, "Spain"=>1, "New Zealand"=>1, "Canada"=>2, "Netherlands"=>1, "Qatar"=>1, "Luxembourg"=>1, "China"=>1, "Brazil"=>1, "Italy"=>3, "France"=>1, "Germany"=>1}, "group_count"=>7}

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