The Impact of Endurance Training on Human Skeletal Muscle Memory, Global Isoform Expression and Novel Transcripts
Publication Date
September 22, 2016
Journal
PLOS Genetics
Authors
Maléne E Lindholm, Stefania Giacomello, Beata Werne Solnestam, Helene Fischer, et al
Volume
12
Issue
9
Pages
e1006294
DOI
https://dx.plos.org/10.1371/journal.pgen.1006294
Publisher URL
http://journals.plos.org/plosgenetics/article?id=10.1371%2Fjournal.pgen.1006294
Scopus
84990249850
Mendeley
http://www.mendeley.com/research/impact-endurance-training-human-skeletal-muscle-memory-global-isoform-expression-novel-transcripts-1
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Mendeley | Further Information

{"title"=>"The Impact of Endurance Training on Human Skeletal Muscle Memory, Global Isoform Expression and Novel Transcripts", "type"=>"journal", "authors"=>[{"first_name"=>"Maléne E.", "last_name"=>"Lindholm", "scopus_author_id"=>"55922520200"}, {"first_name"=>"Stefania", "last_name"=>"Giacomello", "scopus_author_id"=>"55736172800"}, {"first_name"=>"Beata", "last_name"=>"Werne Solnestam", "scopus_author_id"=>"56668738000"}, {"first_name"=>"Helene", "last_name"=>"Fischer", "scopus_author_id"=>"8869319900"}, {"first_name"=>"Mikael", "last_name"=>"Huss", "scopus_author_id"=>"55927880800"}, {"first_name"=>"Sanela", "last_name"=>"Kjellqvist", "scopus_author_id"=>"55450532200"}, {"first_name"=>"Carl Johan", "last_name"=>"Sundberg", "scopus_author_id"=>"7102088972"}], "year"=>2016, "source"=>"PLoS Genetics", "identifiers"=>{"doi"=>"10.1371/journal.pgen.1006294", "sgr"=>"84990249850", "pmid"=>"27657503", "issn"=>"15537404", "scopus"=>"2-s2.0-84990249850", "pui"=>"612628946"}, "id"=>"cf0ce0de-6428-3306-99ab-2acc42bdc659", "abstract"=>"Regularly performed endurance training has many beneficial effects on health and skeletal muscle function, and can be used to prevent and treat common diseases e.g. cardiovascular disease, type II diabetes and obesity. The molecular adaptation mechanisms regulating these effects are incompletely understood. To date, global transcriptome changes in skeletal muscles have been studied at the gene level only. Therefore, global isoform expression changes following exercise training in humans are unknown. Also, the effects of repeated interventions on transcriptional memory or training response have not been studied before. In this study, 23 individuals trained one leg for three months. Nine months later, 12 of the same subjects trained both legs in a second training period. Skeletal muscle biopsies were obtained from both legs before and after both training periods. RNA sequencing analysis of all 119 skeletal muscle biopsies showed that training altered the expression of 3,404 gene isoforms, mainly associated with oxidative ATP production. Fifty-four genes had isoforms that changed in opposite directions. Training altered expression of 34 novel transcripts, all with protein-coding potential. After nine months of detraining, no training-induced transcriptome differences were detected between the previously trained and untrained legs. Although there were several differences in the physiological and transcriptional responses to repeated training, no coherent evidence of an endurance training induced transcriptional skeletal muscle memory was found. This human lifestyle intervention induced differential expression of thousands of isoforms and several transcripts from unannotated regions of the genome. It is likely that the observed isoform expression changes reflect adaptational mechanisms and processes that provide the functional and health benefits of regular physical activity.", "link"=>"http://www.mendeley.com/research/impact-endurance-training-human-skeletal-muscle-memory-global-isoform-expression-novel-transcripts-1", "reader_count"=>34, "reader_count_by_academic_status"=>{"Unspecified"=>3, "Researcher"=>5, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>10, "Student > Postgraduate"=>2, "Other"=>3, "Student > Master"=>1, "Student > Bachelor"=>6, "Lecturer"=>1, "Lecturer > Senior Lecturer"=>1, "Professor"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>3, "Researcher"=>5, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>10, "Student > Postgraduate"=>2, "Other"=>3, "Student > Master"=>1, "Student > Bachelor"=>6, "Lecturer"=>1, "Lecturer > Senior Lecturer"=>1, "Professor"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>5, "Biochemistry, Genetics and Molecular Biology"=>3, "Medicine and Dentistry"=>4, "Agricultural and Biological Sciences"=>13, "Neuroscience"=>4, "Sports and Recreations"=>5}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>4}, "Neuroscience"=>{"Neuroscience"=>4}, "Sports and Recreations"=>{"Sports and Recreations"=>5}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>13}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>3}, "Unspecified"=>{"Unspecified"=>5}}, "group_count"=>2}

Scopus | Further Information

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