Structural and Functional Recovery of Sensory Cilia in C. elegans IFT Mutants upon Aging
Publication Date
December 01, 2016
Authors
Astrid Cornils, Ashish K. Maurya, Lauren Tereshko, Julie Kennedy, et al
Volume
12
Issue
12
Pages
e1006325
DOI
https://dx.plos.org/10.1371/journal.pgen.1006325
Publisher URL
http://journals.plos.org/plosgenetics/article?id=10.1371%2Fjournal.pgen.1006325
Scopus
85007530475
Mendeley
http://www.mendeley.com/research/structural-functional-recovery-sensory-cilia-c-elegans-ift-mutants-upon-aging
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Mendeley | Further Information

{"title"=>"Structural and Functional Recovery of Sensory Cilia in C. elegans IFT Mutants upon Aging", "type"=>"journal", "authors"=>[{"first_name"=>"Astrid", "last_name"=>"Cornils", "scopus_author_id"=>"56636252800"}, {"first_name"=>"Ashish K.", "last_name"=>"Maurya", "scopus_author_id"=>"57192707855"}, {"first_name"=>"Lauren", "last_name"=>"Tereshko", "scopus_author_id"=>"57192712628"}, {"first_name"=>"Julie", "last_name"=>"Kennedy", "scopus_author_id"=>"55867796600"}, {"first_name"=>"Andrea G.", "last_name"=>"Brear", "scopus_author_id"=>"36493821000"}, {"first_name"=>"Veena", "last_name"=>"Prahlad", "scopus_author_id"=>"6602675035"}, {"first_name"=>"Oliver E.", "last_name"=>"Blacque", "scopus_author_id"=>"57201560247"}, {"first_name"=>"Piali", "last_name"=>"Sengupta", "scopus_author_id"=>"7103155424"}], "year"=>2016, "source"=>"PLoS Genetics", "identifiers"=>{"sgr"=>"85007530475", "pmid"=>"27906968", "pui"=>"613954161", "isbn"=>"1553-7390", "scopus"=>"2-s2.0-85007530475", "doi"=>"10.1371/journal.pgen.1006325", "issn"=>"15537404"}, "id"=>"3a6b4e13-3496-3f04-9257-a510822fcdd2", "abstract"=>"The majority of cilia are formed and maintained by the highly conserved process of intraflagellar transport (IFT). Mutations in IFT genes lead to ciliary structural defects and systemic disorders termed ciliopathies. Here we show that the severely truncated sensory cilia of hypomorphic IFT mutants in C. elegans transiently elongate during a discrete period of adult aging leading to markedly improved sensory behaviors. Age-dependent restoration of cilia morphology occurs in structurally diverse cilia types and requires IFT. We demonstrate that while DAF-16/FOXO is dispensable, the age-dependent suppression of cilia phenotypes in IFT mutants requires cell-autonomous functions of the HSF1 heat shock factor and the Hsp90 chaperone. Our results describe an unexpected role of early aging and protein quality control mechanisms in suppressing ciliary phenotypes of IFT mutants, and suggest possible strategies for targeting subsets of ciliopathies.", "link"=>"http://www.mendeley.com/research/structural-functional-recovery-sensory-cilia-c-elegans-ift-mutants-upon-aging", "reader_count"=>23, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Professor > Associate Professor"=>2, "Researcher"=>8, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>2, "Student > Postgraduate"=>1, "Student > Bachelor"=>6, "Professor"=>2}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Professor > Associate Professor"=>2, "Researcher"=>8, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>2, "Student > Postgraduate"=>1, "Student > Bachelor"=>6, "Professor"=>2}, "reader_count_by_subject_area"=>{"Unspecified"=>1, "Engineering"=>1, "Biochemistry, Genetics and Molecular Biology"=>5, "Agricultural and Biological Sciences"=>10, "Medicine and Dentistry"=>1, "Neuroscience"=>3, "Business, Management and Accounting"=>1, "Physics and Astronomy"=>1}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>1}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>1}, "Neuroscience"=>{"Neuroscience"=>3}, "Physics and Astronomy"=>{"Physics and Astronomy"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>10}, "Business, Management and Accounting"=>{"Business, Management and Accounting"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>5}, "Unspecified"=>{"Unspecified"=>1}}, "reader_count_by_country"=>{"United States"=>1}, "group_count"=>0}

Scopus | Further Information

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