Dom34 Links Translation to Protein O-mannosylation
Publication Date
October 21, 2016
Journal
PLOS Genetics
Authors
Lasse Van Wijlick, René Geissen, Jessica S. Hilbig, Quentin Lagadec, et al
Volume
12
Issue
10
Pages
e1006395
DOI
https://dx.plos.org/10.1371/journal.pgen.1006395
Publisher URL
http://journals.plos.org/plosgenetics/article?id=10.1371%2Fjournal.pgen.1006395
Scopus
84994235604
Mendeley
http://www.mendeley.com/research/dom34-links-translation-protein-omannosylation
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Mendeley | Further Information

{"title"=>"Dom34 Links Translation to Protein O-mannosylation", "type"=>"journal", "authors"=>[{"first_name"=>"Lasse", "last_name"=>"van Wijlick", "scopus_author_id"=>"56556985200"}, {"first_name"=>"René", "last_name"=>"Geissen", "scopus_author_id"=>"35743403800"}, {"first_name"=>"Jessica S.", "last_name"=>"Hilbig", "scopus_author_id"=>"57191858073"}, {"first_name"=>"Quentin", "last_name"=>"Lagadec", "scopus_author_id"=>"57191109082"}, {"first_name"=>"Pilar D.", "last_name"=>"Cantero", "scopus_author_id"=>"15519357100"}, {"first_name"=>"Eugen", "last_name"=>"Pfeifer", "scopus_author_id"=>"57191867044"}, {"first_name"=>"Mateusz", "last_name"=>"Juchimiuk", "scopus_author_id"=>"26655778800"}, {"first_name"=>"Sven", "last_name"=>"Kluge", "scopus_author_id"=>"57191859287"}, {"first_name"=>"Stephan", "last_name"=>"Wickert", "scopus_author_id"=>"6602626040"}, {"first_name"=>"Paula", "last_name"=>"Alepuz", "scopus_author_id"=>"6603311983"}, {"first_name"=>"Joachim F.", "last_name"=>"Ernst", "scopus_author_id"=>"55940371400"}], "year"=>2016, "source"=>"PLoS Genetics", "identifiers"=>{"issn"=>"15537404", "sgr"=>"84994235604", "doi"=>"10.1371/journal.pgen.1006395", "scopus"=>"2-s2.0-84994235604", "pmid"=>"27768707", "pui"=>"613127864"}, "id"=>"a3bf35b1-4498-39ce-84b4-26fae067f955", "abstract"=>"In eukaryotes, Dom34 upregulates translation by securing levels of activatable ribosomal subunits. We found that in the yeast Saccharomyces cerevisiae and the human fungal pathogen Candida albicans, Dom34 interacts genetically with Pmt1, a major isoform of protein O-mannosyltransferase. In C. albicans, lack of Dom34 exacerbated defective phenotypes of pmt1 mutants, while they were ameliorated by Dom34 overproduction that enhanced Pmt1 protein but not PMT1 transcript levels. Translational effects of Dom34 required the 5'-UTR of the PMT1 transcript, which bound recombinant Dom34 directly at a CA/AC-rich sequence and regulated in vitro translation. Polysomal profiling revealed that Dom34 stimulates general translation moderately, but that it is especially required for translation of transcripts encoding Pmt isoforms 1, 4 and 6. Because defective protein N- or O-glycosylation upregulates transcription of PMT genes, it appears that Dom34-mediated specific translational upregulation of the PMT transcripts optimizes cellular responses to glycostress. Its translational function as an RNA binding protein acting at the 5'-UTR of specific transcripts adds another facet to the known ribosome-releasing functions of Dom34 at the 3'-UTR of transcripts.", "link"=>"http://www.mendeley.com/research/dom34-links-translation-protein-omannosylation", "reader_count"=>11, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>1, "Student > Ph. D. Student"=>2, "Student > Master"=>1, "Other"=>2, "Student > Bachelor"=>2, "Lecturer"=>1, "Professor"=>1, "Researcher"=>1}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>1, "Student > Ph. D. Student"=>2, "Student > Master"=>1, "Other"=>2, "Student > Bachelor"=>2, "Lecturer"=>1, "Professor"=>1, "Researcher"=>1}, "reader_count_by_subject_area"=>{"Biochemistry, Genetics and Molecular Biology"=>3, "Agricultural and Biological Sciences"=>6, "Social Sciences"=>1, "Immunology and Microbiology"=>1}, "reader_count_by_subdiscipline"=>{"Social Sciences"=>{"Social Sciences"=>1}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>6}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>3}}, "group_count"=>0}

Scopus | Further Information

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