Genetic variants alter T-bet binding and gene expression in mucosal inflammatory disease
Publication Date
February 10, 2017
Authors
Katrina Soderquest, Arnulf Hertweck, Claudia Giambartolomei, Stephen Henderson, et al
Volume
13
Issue
2
Pages
e1006587
DOI
https://dx.plos.org/10.1371/journal.pgen.1006587
Publisher URL
http://journals.plos.org/plosgenetics/article?id=10.1371%2Fjournal.pgen.1006587
Scopus
85014094487
Mendeley
http://www.mendeley.com/research/genetic-variants-alter-tbet-binding-gene-expression-mucosal-inflammatory-disease
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Mendeley | Further Information

{"title"=>"Genetic variants alter T-bet binding and gene expression in mucosal inflammatory disease", "type"=>"journal", "authors"=>[{"first_name"=>"Katrina", "last_name"=>"Soderquest", "scopus_author_id"=>"36562541800"}, {"first_name"=>"Arnulf", "last_name"=>"Hertweck", "scopus_author_id"=>"24390236700"}, {"first_name"=>"Claudia", "last_name"=>"Giambartolomei", "scopus_author_id"=>"26667661600"}, {"first_name"=>"Stephen", "last_name"=>"Henderson", "scopus_author_id"=>"35548946900"}, {"first_name"=>"Rami", "last_name"=>"Mohamed", "scopus_author_id"=>"57185095700"}, {"first_name"=>"Rimma", "last_name"=>"Goldberg", "scopus_author_id"=>"56652991900"}, {"first_name"=>"Esperanza", "last_name"=>"Perucha", "scopus_author_id"=>"8689558300"}, {"first_name"=>"Lude", "last_name"=>"Franke", "scopus_author_id"=>"56310093600"}, {"first_name"=>"Javier", "last_name"=>"Herrero", "scopus_author_id"=>"23477304600"}, {"first_name"=>"Vincent", "last_name"=>"Plagnol", "scopus_author_id"=>"16402494600"}, {"first_name"=>"Richard G.", "last_name"=>"Jenner", "scopus_author_id"=>"7004044168"}, {"first_name"=>"Graham M.", "last_name"=>"Lord", "scopus_author_id"=>"7006574717"}], "year"=>2017, "source"=>"PLoS Genetics", "identifiers"=>{"pmid"=>"28187197", "doi"=>"10.1371/journal.pgen.1006587", "sgr"=>"85014094487", "isbn"=>"1111111111", "scopus"=>"2-s2.0-85014094487", "issn"=>"15537404", "pui"=>"614651114"}, "id"=>"807e6a2f-f681-37b4-9f0e-a14fb3980e17", "abstract"=>"The polarization of CD4+ T cells into distinct T helper cell lineages is essential for protective immunity against infection, but aberrant T cell polarization can cause autoimmunity. The transcription factor T-bet (TBX21) specifies the Th1 lineage and represses alternative T cell fates. Genome-wide association studies have identified single nucleotide polymorphisms (SNPs) that may be causative for autoimmune diseases. The majority of these polymorphisms are located within non-coding distal regulatory elements. It is considered that these genetic variants contribute to disease by altering the binding of regulatory proteins and thus gene expression, but whether these variants alter the binding of lineage-specifying transcription factors has not been determined. Here, we show that SNPs associated with the mucosal inflammatory diseases Crohn's disease, ulcerative colitis (UC) and celiac disease, but not rheumatoid arthritis or psoriasis, are enriched at T-bet binding sites. Furthermore, we identify disease-associated variants that alter T-bet binding in vitro and in vivo. ChIP-seq for T-bet in individuals heterozygous for the celiac disease-associated SNPs rs1465321 and rs2058622 and the IBD-associated SNPs rs1551398 and rs1551399, reveals decreased binding to the minor disease-associated alleles. Furthermore, we show that rs1465321 is an expression quantitative trait locus (eQTL) for the neighboring gene IL18RAP, with decreased T-bet binding associated with decreased expression of this gene. These results suggest that genetic polymorphisms may predispose individuals to mucosal autoimmune disease through alterations in T-bet binding. Other disease-associated variants may similarly act by modulating the binding of lineage-specifying transcription factors in a tissue-selective and disease-specific manner.", "link"=>"http://www.mendeley.com/research/genetic-variants-alter-tbet-binding-gene-expression-mucosal-inflammatory-disease", "reader_count"=>21, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Professor > Associate Professor"=>2, "Researcher"=>6, "Student > Ph. D. Student"=>4, "Student > Postgraduate"=>1, "Student > Master"=>4, "Student > Bachelor"=>2, "Lecturer"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Professor > Associate Professor"=>2, "Researcher"=>6, "Student > Ph. D. Student"=>4, "Student > Postgraduate"=>1, "Student > Master"=>4, "Student > Bachelor"=>2, "Lecturer"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>1, "Biochemistry, Genetics and Molecular Biology"=>4, "Agricultural and Biological Sciences"=>4, "Medicine and Dentistry"=>10, "Computer Science"=>1, "Immunology and Microbiology"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>10}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>4}, "Computer Science"=>{"Computer Science"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>4}, "Unspecified"=>{"Unspecified"=>1}}, "reader_count_by_country"=>{"United Kingdom"=>1}, "group_count"=>0}

Scopus | Further Information

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