Genetic prediction of male pattern baldness
Publication Date
February 14, 2017
Authors
Saskia P. Hagenaars, W. David Hill, Sarah E. Harris, Stuart J. Ritchie, et al
Volume
13
Issue
2
Pages
e1006594
DOI
https://dx.plos.org/10.1371/journal.pgen.1006594
Publisher URL
http://journals.plos.org/plosgenetics/article?id=10.1371%2Fjournal.pgen.1006594
Scopus
85014122426
Mendeley
http://www.mendeley.com/research/genetic-prediction-male-pattern-baldness
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{"title"=>"Genetic prediction of male pattern baldness", "type"=>"journal", "authors"=>[{"first_name"=>"Saskia P.", "last_name"=>"Hagenaars", "scopus_author_id"=>"55983441400"}, {"first_name"=>"W. David", "last_name"=>"Hill", "scopus_author_id"=>"7202970264"}, {"first_name"=>"Sarah E.", "last_name"=>"Harris", "scopus_author_id"=>"7403484635"}, {"first_name"=>"Stuart J.", "last_name"=>"Ritchie", "scopus_author_id"=>"48861815000"}, {"first_name"=>"Gail", "last_name"=>"Davies", "scopus_author_id"=>"7402854331"}, {"first_name"=>"David C.", "last_name"=>"Liewald", "scopus_author_id"=>"57193577522"}, {"first_name"=>"Catharine R.", "last_name"=>"Gale", "scopus_author_id"=>"7102850916"}, {"first_name"=>"David J.", "last_name"=>"Porteous", "scopus_author_id"=>"7006940003"}, {"first_name"=>"Ian J.", "last_name"=>"Deary", "scopus_author_id"=>"56705691500"}, {"first_name"=>"Riccardo E.", "last_name"=>"Marioni", "scopus_author_id"=>"24470564300"}], "year"=>2017, "source"=>"PLoS Genetics", "identifiers"=>{"scopus"=>"2-s2.0-85014122426", "sgr"=>"85014122426", "issn"=>"15537404", "doi"=>"10.1371/journal.pgen.1006594", "pmid"=>"28196072", "isbn"=>"1553-7404 (Electronic) 1553-7390 (Linking)", "pui"=>"614651001"}, "id"=>"176346f0-2ee5-3b76-8650-fe8c25cf7ce7", "abstract"=>"Male pattern baldness can have substantial psychosocial effects, and it has been phenotypically linked to adverse health outcomes such as prostate cancer and cardiovascular disease. We explored the genetic architecture of the trait using data from over 52,000 male participants of UK Biobank, aged 40-69 years. We identified over 250 independent genetic loci associated with severe hair loss (P<5x10-8). By splitting the cohort into a discovery sample of 40,000 and target sample of 12,000, we developed a prediction algorithm based entirely on common genetic variants that discriminated (AUC = 0.78, sensitivity = 0.74, specificity = 0.69, PPV = 59%, NPV = 82%) those with no hair loss from those with severe hair loss. The results of this study might help identify those at greatest risk of hair loss, and also potential genetic targets for intervention.", "link"=>"http://www.mendeley.com/research/genetic-prediction-male-pattern-baldness", "reader_count"=>57, "reader_count_by_academic_status"=>{"Unspecified"=>3, "Professor > Associate Professor"=>4, "Researcher"=>14, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>9, "Student > Postgraduate"=>1, "Other"=>6, "Student > Master"=>11, "Student > Bachelor"=>6, "Lecturer > Senior Lecturer"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>3, "Professor > Associate Professor"=>4, "Researcher"=>14, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>9, "Student > Postgraduate"=>1, "Other"=>6, "Student > Master"=>11, "Student > Bachelor"=>6, "Lecturer > Senior Lecturer"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>5, "Agricultural and Biological Sciences"=>18, "Arts and Humanities"=>1, "Chemistry"=>2, "Computer Science"=>5, "Earth and Planetary Sciences"=>1, "Engineering"=>1, "Biochemistry, Genetics and Molecular Biology"=>7, "Nursing and Health Professions"=>1, "Mathematics"=>2, "Medicine and Dentistry"=>6, "Neuroscience"=>1, "Pharmacology, Toxicology and Pharmaceutical Science"=>3, "Sports and Recreations"=>1, "Physics and Astronomy"=>2, "Immunology and Microbiology"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>6}, "Sports and Recreations"=>{"Sports and Recreations"=>1}, "Physics and Astronomy"=>{"Physics and Astronomy"=>2}, "Mathematics"=>{"Mathematics"=>2}, "Unspecified"=>{"Unspecified"=>5}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>3}, "Arts and Humanities"=>{"Arts and Humanities"=>1}, "Engineering"=>{"Engineering"=>1}, "Chemistry"=>{"Chemistry"=>2}, "Neuroscience"=>{"Neuroscience"=>1}, "Earth and Planetary Sciences"=>{"Earth and Planetary Sciences"=>1}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>18}, "Computer Science"=>{"Computer Science"=>5}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>7}}, "reader_count_by_country"=>{"United States"=>1, "Luxembourg"=>1, "United Kingdom"=>1, "Germany"=>1}, "group_count"=>7}

Scopus | Further Information

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