Depletion of Arabidopsis SC35 and SC35-like serine/arginine-rich proteins affects the transcription and splicing of a subset of genes
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{"title"=>"Depletion of Arabidopsis SC35 and SC35-like serine/arginine-rich proteins affects the transcription and splicing of a subset of genes", "type"=>"journal", "authors"=>[{"first_name"=>"Qingqing", "last_name"=>"Yan", "scopus_author_id"=>"55840353200"}, {"first_name"=>"Xi", "last_name"=>"Xia", "scopus_author_id"=>"57193795512"}, {"first_name"=>"Zhenfei", "last_name"=>"Sun", "scopus_author_id"=>"55840660000"}, {"first_name"=>"Yuda", "last_name"=>"Fang", "scopus_author_id"=>"7403457314"}], "year"=>2017, "source"=>"PLoS Genetics", "identifiers"=>{"isbn"=>"1111111111", "scopus"=>"2-s2.0-85016631274", "issn"=>"15537404", "pui"=>"615142185", "pmid"=>"28273088", "sgr"=>"85016631274", "doi"=>"10.1371/journal.pgen.1006663"}, "id"=>"027504e9-24a1-35ff-b590-6d4f9411e603", "abstract"=>"Serine/arginine-rich (SR) proteins are important splicing factors which play significant roles in spliceosome assembly and splicing regulation. However, little is known regarding their biological functions in plants. Here, we analyzed the phenotypes of mutants upon depleting different subfamilies of Arabidopsis SR proteins. We found that loss of the functions of SC35 and SC35-like (SCL) proteins cause pleiotropic changes in plant morphology and development, including serrated leaves, late flowering, shorter roots and abnormal silique phyllotaxy. Using RNA-seq, we found that SC35 and SCL proteins play roles in the pre-mRNA splicing. Motif analysis revealed that SC35 and SCL proteins preferentially bind to a specific RNA sequence containing the AGAAGA motif. In addition, the transcriptions of a subset of genes are affected by the deletion of SC35 and SCL proteins which interact with NRPB4, a specific subunit of RNA polymerase II. The splicing of FLOWERING LOCUS C (FLC) intron1 and transcription of FLC were significantly regulated by SC35 and SCL proteins to control Arabidopsis flowering. Therefore, our findings provide mechanistic insight into the functions of plant SC35 and SCL proteins in the regulation of splicing and transcription in a direct or indirect manner to maintain the proper expression of genes and development.", "link"=>"http://www.mendeley.com/research/depletion-arabidopsis-sc35-sc35like-serineargininerich-proteins-affects-transcription-splicing-subse", "reader_count"=>26, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>1, "Student > Doctoral Student"=>1, "Researcher"=>4, "Student > Ph. D. Student"=>8, "Student > Postgraduate"=>1, "Student > Master"=>3, "Other"=>1, "Student > Bachelor"=>4, "Lecturer"=>1, "Lecturer > Senior Lecturer"=>1, "Professor"=>1}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>1, "Student > Doctoral Student"=>1, "Researcher"=>4, "Student > Ph. D. Student"=>8, "Student > Postgraduate"=>1, "Student > Master"=>3, "Other"=>1, "Student > Bachelor"=>4, "Lecturer"=>1, "Lecturer > Senior Lecturer"=>1, "Professor"=>1}, "reader_count_by_subject_area"=>{"Biochemistry, Genetics and Molecular Biology"=>5, "Agricultural and Biological Sciences"=>21}, "reader_count_by_subdiscipline"=>{"Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>21}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>5}}, "reader_count_by_country"=>{"United Kingdom"=>1, "Spain"=>1}, "group_count"=>0}

Scopus | Further Information

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Source
Scopus
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2019-08-27 21:07:30 UTC
Target URL
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