Phenome-wide heritability analysis of the UK Biobank
Publication Date
April 07, 2017
Authors
Tian Ge, Chia Yen Chen, Benjamin M. Neale, Mert R. Sabuncu, et al
Volume
13
Issue
4
Pages
e1006711
DOI
https://dx.plos.org/10.1371/journal.pgen.1006711
Publisher URL
http://journals.plos.org/plosgenetics/article?id=10.1371%2Fjournal.pgen.1006711
Scopus
85018389876
Mendeley
http://www.mendeley.com/research/phenomewide-heritability-analysis-uk-biobank
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Mendeley | Further Information

{"title"=>"Phenome-wide heritability analysis of the UK Biobank", "type"=>"journal", "authors"=>[{"first_name"=>"Tian", "last_name"=>"Ge", "scopus_author_id"=>"35326917500"}, {"first_name"=>"Chia Yen", "last_name"=>"Chen", "scopus_author_id"=>"56533405900"}, {"first_name"=>"Benjamin M.", "last_name"=>"Neale", "scopus_author_id"=>"7003484514"}, {"first_name"=>"Mert R.", "last_name"=>"Sabuncu", "scopus_author_id"=>"6603132006"}, {"first_name"=>"Jordan W.", "last_name"=>"Smoller", "scopus_author_id"=>"7006674071"}], "year"=>2017, "source"=>"PLoS Genetics", "identifiers"=>{"issn"=>"15537404", "doi"=>"10.1371/journal.pgen.1006711", "sgr"=>"85018389876", "scopus"=>"2-s2.0-85018389876", "isbn"=>"1111111111", "pmid"=>"28388634", "pui"=>"615859609"}, "id"=>"e411d609-81ac-38c7-9a56-50aeb8700b8d", "abstract"=>"Heritability estimation provides important information about the relative contribution of genetic and environmental factors to phenotypic variation, and provides an upper bound for the utility of genetic risk prediction models. Recent technological and statistical advances have enabled the estimation of additive heritability attributable to common genetic variants (SNP heritability) across a broad phenotypic spectrum. However, assessing the comparative heritability of multiple traits estimated in different cohorts may be misleading due to the population-specific nature of heritability. Here we report the SNP heritability for 551 complex traits derived from the large-scale, population-based UK Biobank, comprising both quantitative phenotypes and disease codes, and examine the moderating effect of three major demographic variables (age, sex and socioeconomic status) on the heritability estimates. Our study represents the first comprehensive phenome-wide heritability analysis in the UK Biobank, and underscores the importance of considering population characteristics in comparing and interpreting heritability.", "link"=>"http://www.mendeley.com/research/phenomewide-heritability-analysis-uk-biobank", "reader_count"=>126, "reader_count_by_academic_status"=>{"Unspecified"=>6, "Professor > Associate Professor"=>5, "Researcher"=>39, "Student > Doctoral Student"=>3, "Student > Ph. D. Student"=>31, "Student > Postgraduate"=>3, "Student > Master"=>12, "Other"=>7, "Student > Bachelor"=>7, "Professor"=>13}, "reader_count_by_user_role"=>{"Unspecified"=>6, "Professor > Associate Professor"=>5, "Researcher"=>39, "Student > Doctoral Student"=>3, "Student > Ph. D. Student"=>31, "Student > Postgraduate"=>3, "Student > Master"=>12, "Other"=>7, "Student > Bachelor"=>7, "Professor"=>13}, "reader_count_by_subject_area"=>{"Unspecified"=>13, "Agricultural and Biological Sciences"=>40, "Computer Science"=>6, "Economics, Econometrics and Finance"=>1, "Engineering"=>3, "Environmental Science"=>1, "Biochemistry, Genetics and Molecular Biology"=>32, "Nursing and Health Professions"=>1, "Mathematics"=>1, "Medicine and Dentistry"=>16, "Neuroscience"=>2, "Physics and Astronomy"=>1, "Psychology"=>8, "Social Sciences"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>16}, "Social Sciences"=>{"Social Sciences"=>1}, "Physics and Astronomy"=>{"Physics and Astronomy"=>1}, "Psychology"=>{"Psychology"=>8}, "Mathematics"=>{"Mathematics"=>1}, "Unspecified"=>{"Unspecified"=>13}, "Environmental Science"=>{"Environmental Science"=>1}, "Engineering"=>{"Engineering"=>3}, "Neuroscience"=>{"Neuroscience"=>2}, "Economics, Econometrics and Finance"=>{"Economics, Econometrics and Finance"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>40}, "Computer Science"=>{"Computer Science"=>6}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>32}}, "reader_count_by_country"=>{"Canada"=>1, "United States"=>2, "Luxembourg"=>1, "Finland"=>1, "Italy"=>1, "United Kingdom"=>2, "Australia"=>1, "Germany"=>1, "Spain"=>2}, "group_count"=>5}

CrossRef

Scopus | Further Information

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