Overexpression of the essential Sis1 chaperone reduces TDP-43 effects on toxicity and proteolysis
Publication Date
May 22, 2017
Authors
Sei Kyoung Park, Joo Y. Hong, Fatih Arslan, Vydehi Kanneganti, et al
Volume
13
Issue
5
Pages
e1006805
DOI
https://dx.plos.org/10.1371/journal.pgen.1006805
Publisher URL
http://journals.plos.org/plosgenetics/article?id=10.1371%2Fjournal.pgen.1006805
Scopus
85020184051
Mendeley
http://www.mendeley.com/research/overexpression-essential-sis1-chaperone-reduces-tdp43-effects-toxicity-proteolysis
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Mendeley | Further Information

{"title"=>"Overexpression of the essential Sis1 chaperone reduces TDP-43 effects on toxicity and proteolysis", "type"=>"journal", "authors"=>[{"first_name"=>"Sei Kyoung", "last_name"=>"Park", "scopus_author_id"=>"57191671234"}, {"first_name"=>"Joo Y.", "last_name"=>"Hong", "scopus_author_id"=>"7404118379"}, {"first_name"=>"Fatih", "last_name"=>"Arslan", "scopus_author_id"=>"56652719400"}, {"first_name"=>"Vydehi", "last_name"=>"Kanneganti", "scopus_author_id"=>"56593689200"}, {"first_name"=>"Basant", "last_name"=>"Patel", "scopus_author_id"=>"56998136300"}, {"first_name"=>"Alex", "last_name"=>"Tietsort", "scopus_author_id"=>"57194442176"}, {"first_name"=>"Elizabeth M.H.", "last_name"=>"Tank", "scopus_author_id"=>"7004656105"}, {"first_name"=>"Xingli", "last_name"=>"Li", "scopus_author_id"=>"55314141300"}, {"first_name"=>"Sami J.", "last_name"=>"Barmada", "scopus_author_id"=>"7004111795"}, {"first_name"=>"Susan W.", "last_name"=>"Liebman", "scopus_author_id"=>"7005026073"}], "year"=>2017, "source"=>"PLoS Genetics", "identifiers"=>{"sgr"=>"85020184051", "pmid"=>"28531192", "pui"=>"616626825", "isbn"=>"1111111111", "scopus"=>"2-s2.0-85020184051", "doi"=>"10.1371/journal.pgen.1006805", "issn"=>"15537404"}, "id"=>"dbd1479f-59d1-3e6f-998c-facdba2bccb9", "abstract"=>"Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease characterized by selective loss of motor neurons with inclusions frequently containing the RNA/DNA binding protein TDP-43. Using a yeast model of ALS exhibiting TDP-43 dependent toxicity, we now show that TDP-43 overexpression dramatically alters cell shape and reduces ubiquitin dependent proteolysis of a reporter construct. Furthermore, we show that an excess of the Hsp40 chaperone, Sis1, reduced TDP-43's effect on toxicity, cell shape and proteolysis. The strength of these effects was influenced by the presence of the endogenous yeast prion, [PIN+]. Although overexpression of Sis1 altered the TDP-43 aggregation pattern, we did not detect physical association of Sis1 with TDP-43, suggesting the possibility of indirect effects on TDP-43 aggregation. Furthermore, overexpression of the mammalian Sis1 homologue, DNAJB1, relieves TDP-43 mediated toxicity in primary rodent cortical neurons, suggesting that Sis1 and its homologues may have neuroprotective effects in ALS.", "link"=>"http://www.mendeley.com/research/overexpression-essential-sis1-chaperone-reduces-tdp43-effects-toxicity-proteolysis", "reader_count"=>23, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Researcher"=>4, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>10, "Student > Postgraduate"=>1, "Student > Bachelor"=>1, "Lecturer"=>1, "Professor"=>2, "Other"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Researcher"=>4, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>10, "Student > Postgraduate"=>1, "Student > Bachelor"=>1, "Lecturer"=>1, "Professor"=>2, "Other"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>2, "Biochemistry, Genetics and Molecular Biology"=>6, "Agricultural and Biological Sciences"=>8, "Medicine and Dentistry"=>2, "Neuroscience"=>3, "Pharmacology, Toxicology and Pharmaceutical Science"=>2}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>2}, "Neuroscience"=>{"Neuroscience"=>3}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>8}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>6}, "Unspecified"=>{"Unspecified"=>2}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>2}}, "reader_count_by_country"=>{"Germany"=>1}, "group_count"=>1}

Scopus | Further Information

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