Genomic introgression mapping of field-derived multiple-anthelmintic resistance in Teladorsagia circumcincta
Publication Date
June 23, 2017
Authors
Young Jun Choi, Stewart A. Bisset, Stephen R. Doyle, Kymberlie Hallsworth Pepin, et al
Volume
13
Issue
6
Pages
e1006857
DOI
https://dx.plos.org/10.1371/journal.pgen.1006857
Publisher URL
http://journals.plos.org/plosgenetics/article?id=10.1371%2Fjournal.pgen.1006857
Scopus
85021841493
Mendeley
http://www.mendeley.com/research/genomic-introgression-mapping-fieldderived-multipleanthelmintic-resistance-teladorsagia-circumcincta
Events
Loading … Spinner

Mendeley | Further Information

{"title"=>"Genomic introgression mapping of field-derived multiple-anthelmintic resistance in Teladorsagia circumcincta", "type"=>"journal", "authors"=>[{"first_name"=>"Young Jun", "last_name"=>"Choi", "scopus_author_id"=>"55685946200"}, {"first_name"=>"Stewart A.", "last_name"=>"Bisset", "scopus_author_id"=>"35610879200"}, {"first_name"=>"Stephen R.", "last_name"=>"Doyle", "scopus_author_id"=>"23477293900"}, {"first_name"=>"Kymberlie", "last_name"=>"Hallsworth-Pepin", "scopus_author_id"=>"36092906100"}, {"first_name"=>"John", "last_name"=>"Martin", "scopus_author_id"=>"56537265100"}, {"first_name"=>"Warwick N.", "last_name"=>"Grant", "scopus_author_id"=>"55675758900"}, {"first_name"=>"Makedonka", "last_name"=>"Mitreva", "scopus_author_id"=>"6507392205"}], "year"=>2017, "source"=>"PLoS Genetics", "identifiers"=>{"sgr"=>"85021841493", "pmid"=>"28644839", "pui"=>"617190757", "isbn"=>"1111111111", "scopus"=>"2-s2.0-85021841493", "doi"=>"10.1371/journal.pgen.1006857", "issn"=>"15537404"}, "id"=>"08058eb3-95ab-3b0c-89b3-94c79ccf3c8d", "abstract"=>"Preventive chemotherapy has long been practiced against nematode parasites of livestock, leading to widespread drug resistance, and is increasingly being adopted for eradication of human parasitic nematodes even though it is similarly likely to lead to drug resistance. Given that the genetic architecture of resistance is poorly understood for any nematode, we have analyzed multidrug resistant Teladorsagia circumcincta, a major parasite of sheep, as a model for analysis of resistance selection. We introgressed a field-derived multiresistant genotype into a partially inbred susceptible genetic background (through repeated backcrossing and drug selection) and performed genome-wide scans in the backcross progeny and drug-selected F2 populations to identify the major genes responsible for the multidrug resistance. We identified variation linking candidate resistance genes to each drug class. Putative mechanisms included target site polymorphism, changes in likely regulatory regions and copy number variation in efflux transporters. This work elucidates the genetic architecture of multiple anthelmintic resistance in a parasitic nematode for the first time and establishes a framework for future studies of anthelmintic resistance in nematode parasites of humans.", "link"=>"http://www.mendeley.com/research/genomic-introgression-mapping-fieldderived-multipleanthelmintic-resistance-teladorsagia-circumcincta", "reader_count"=>11, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Professor > Associate Professor"=>1, "Student > Doctoral Student"=>1, "Researcher"=>1, "Student > Ph. D. Student"=>4, "Student > Postgraduate"=>1, "Other"=>1, "Student > Master"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Professor > Associate Professor"=>1, "Student > Doctoral Student"=>1, "Researcher"=>1, "Student > Ph. D. Student"=>4, "Student > Postgraduate"=>1, "Other"=>1, "Student > Master"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>3, "Biochemistry, Genetics and Molecular Biology"=>4, "Agricultural and Biological Sciences"=>3, "Veterinary Science and Veterinary Medicine"=>1}, "reader_count_by_subdiscipline"=>{"Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>3}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>4}, "Unspecified"=>{"Unspecified"=>3}, "Veterinary Science and Veterinary Medicine"=>{"Veterinary Science and Veterinary Medicine"=>1}}, "reader_count_by_country"=>{"Netherlands"=>1}, "group_count"=>1}

Scopus | Further Information

{"@_fa"=>"true", "link"=>[{"@_fa"=>"true", "@ref"=>"self", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/85021841493"}, {"@_fa"=>"true", "@ref"=>"author-affiliation", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/85021841493?field=author,affiliation"}, {"@_fa"=>"true", "@ref"=>"scopus", "@href"=>"https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85021841493&origin=inward"}, {"@_fa"=>"true", "@ref"=>"scopus-citedby", "@href"=>"https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=85021841493&origin=inward"}], "prism:url"=>"https://api.elsevier.com/content/abstract/scopus_id/85021841493", "dc:identifier"=>"SCOPUS_ID:85021841493", "eid"=>"2-s2.0-85021841493", "dc:title"=>"Genomic introgression mapping of field-derived multiple-anthelmintic resistance in Teladorsagia circumcincta", "dc:creator"=>"Choi Y.", "prism:publicationName"=>"PLoS Genetics", "prism:issn"=>"15537390", "prism:eIssn"=>"15537404", "prism:volume"=>"13", "prism:issueIdentifier"=>"6", "prism:pageRange"=>nil, "prism:coverDate"=>"2017-01-01", "prism:coverDisplayDate"=>"2017", "prism:doi"=>"10.1371/journal.pgen.1006857", "citedby-count"=>"11", "affiliation"=>[{"@_fa"=>"true", "affilname"=>"Washington University School of Medicine in St. Louis", "affiliation-city"=>"St Louis", "affiliation-country"=>"United States"}], "pubmed-id"=>"28644839", "prism:aggregationType"=>"Journal", "subtype"=>"ar", "subtypeDescription"=>"Article", "article-number"=>"e1006857", "source-id"=>"4000151808", "openaccess"=>"1", "openaccessFlag"=>true}

Counter

  • {"month"=>"6", "year"=>"2017", "pdf_views"=>"51", "xml_views"=>"9", "html_views"=>"1028"}
  • {"month"=>"7", "year"=>"2017", "pdf_views"=>"93", "xml_views"=>"9", "html_views"=>"1299"}
  • {"month"=>"8", "year"=>"2017", "pdf_views"=>"24", "xml_views"=>"0", "html_views"=>"78"}
  • {"month"=>"9", "year"=>"2017", "pdf_views"=>"15", "xml_views"=>"6", "html_views"=>"57"}
  • {"month"=>"10", "year"=>"2017", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"40"}
  • {"month"=>"11", "year"=>"2017", "pdf_views"=>"20", "xml_views"=>"0", "html_views"=>"85"}
  • {"month"=>"12", "year"=>"2017", "pdf_views"=>"20", "xml_views"=>"0", "html_views"=>"55"}
  • {"month"=>"1", "year"=>"2018", "pdf_views"=>"18", "xml_views"=>"0", "html_views"=>"49"}
  • {"month"=>"2", "year"=>"2018", "pdf_views"=>"15", "xml_views"=>"0", "html_views"=>"27"}
  • {"month"=>"3", "year"=>"2018", "pdf_views"=>"15", "xml_views"=>"1", "html_views"=>"30"}
  • {"month"=>"4", "year"=>"2018", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"21"}
  • {"month"=>"5", "year"=>"2018", "pdf_views"=>"19", "xml_views"=>"0", "html_views"=>"37"}
  • {"month"=>"6", "year"=>"2018", "pdf_views"=>"8", "xml_views"=>"1", "html_views"=>"20"}
  • {"month"=>"7", "year"=>"2018", "pdf_views"=>"5", "xml_views"=>"2", "html_views"=>"20"}
  • {"month"=>"8", "year"=>"2018", "pdf_views"=>"5", "xml_views"=>"1", "html_views"=>"22"}
  • {"month"=>"9", "year"=>"2018", "pdf_views"=>"15", "xml_views"=>"0", "html_views"=>"19"}
  • {"month"=>"10", "year"=>"2018", "pdf_views"=>"17", "xml_views"=>"1", "html_views"=>"13"}
  • {"month"=>"11", "year"=>"2018", "pdf_views"=>"16", "xml_views"=>"0", "html_views"=>"35"}
  • {"month"=>"12", "year"=>"2018", "pdf_views"=>"9", "xml_views"=>"1", "html_views"=>"18"}
  • {"month"=>"1", "year"=>"2019", "pdf_views"=>"14", "xml_views"=>"1", "html_views"=>"23"}
  • {"month"=>"2", "year"=>"2019", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"20"}
  • {"month"=>"3", "year"=>"2019", "pdf_views"=>"23", "xml_views"=>"2", "html_views"=>"23"}
  • {"month"=>"4", "year"=>"2019", "pdf_views"=>"30", "xml_views"=>"1", "html_views"=>"13"}
  • {"month"=>"5", "year"=>"2019", "pdf_views"=>"27", "xml_views"=>"1", "html_views"=>"33"}

PMC Usage Stats

  • {"unique-ip"=>"4", "full-text"=>"3", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"7"}
  • {"unique-ip"=>"18", "full-text"=>"14", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2017", "month"=>"8"}
  • {"unique-ip"=>"19", "full-text"=>"16", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2017", "month"=>"9"}
  • {"unique-ip"=>"26", "full-text"=>"11", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"11", "cited-by"=>"1", "year"=>"2017", "month"=>"10"}
  • {"unique-ip"=>"13", "full-text"=>"15", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2017", "month"=>"11"}
  • {"unique-ip"=>"6", "full-text"=>"4", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"1", "cited-by"=>"1", "year"=>"2017", "month"=>"12"}
  • {"unique-ip"=>"8", "full-text"=>"11", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"1"}
  • {"unique-ip"=>"20", "full-text"=>"14", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"5", "cited-by"=>"0", "year"=>"2018", "month"=>"3"}
  • {"unique-ip"=>"27", "full-text"=>"13", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"19", "cited-by"=>"0", "year"=>"2019", "month"=>"1"}
  • {"unique-ip"=>"16", "full-text"=>"18", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2018", "month"=>"5"}
  • {"unique-ip"=>"8", "full-text"=>"3", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2018", "month"=>"4"}
  • {"unique-ip"=>"19", "full-text"=>"20", "pdf"=>"6", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"4", "cited-by"=>"0", "year"=>"2018", "month"=>"6"}
  • {"unique-ip"=>"19", "full-text"=>"7", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"14", "cited-by"=>"0", "year"=>"2018", "month"=>"7"}
  • {"unique-ip"=>"15", "full-text"=>"17", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"14", "cited-by"=>"0", "year"=>"2018", "month"=>"8"}
  • {"unique-ip"=>"31", "full-text"=>"18", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"15", "cited-by"=>"0", "year"=>"2018", "month"=>"9"}
  • {"unique-ip"=>"23", "full-text"=>"12", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"32", "cited-by"=>"0", "year"=>"2018", "month"=>"11"}
  • {"unique-ip"=>"14", "full-text"=>"16", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"10"}
  • {"unique-ip"=>"14", "full-text"=>"12", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2018", "month"=>"12"}
  • {"unique-ip"=>"7", "full-text"=>"7", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"2"}
  • {"unique-ip"=>"11", "full-text"=>"9", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"27", "cited-by"=>"0", "year"=>"2019", "month"=>"3"}
  • {"unique-ip"=>"11", "full-text"=>"8", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2019", "month"=>"4"}
Loading … Spinner
There are currently no alerts