ALM

Multiple renal cancer susceptibility polymorphisms modulate the HIF pathway

Publication Date: July 17, 2017
Authors: Steffen Grampp, Virginia Schmid, Rafik Salama, Victoria Lauer, et al
Volume: 13
Issue: 7
Pages: e1006872
DOI: https://dx.plos.org/10.1371/journal.pgen.1006872
Publisher URL: http://journals.plos.org/plosgenetics/article?id=10.1371%2Fjournal.pgen.1006872
Scopus: 85026651387
Mendeley: http://www.mendeley.com/research/multiple-renal-cancer-susceptibility-polymorphisms-modulate-hif-pathway

Loading …

Events

Loading …

CiteULike

CiteULike

Mendeley 1314 May 06:21 UTC

Mendeley | Further Information

{"title"=>"Multiple renal cancer susceptibility polymorphisms modulate the HIF pathway", "type"=>"journal", "authors"=>[{"first_name"=>"Steffen", "last_name"=>"Grampp", "scopus_author_id"=>"56048775200"}, {"first_name"=>"Virginia", "last_name"=>"Schmid", "scopus_author_id"=>"57195266467"}, {"first_name"=>"Rafik", "last_name"=>"Salama", "scopus_author_id"=>"56888517500"}, {"first_name"=>"Victoria", "last_name"=>"Lauer", "scopus_author_id"=>"57190795568"}, {"first_name"=>"Franziska", "last_name"=>"Kranz", "scopus_author_id"=>"57191647041"}, {"first_name"=>"James L.", "last_name"=>"Platt", "scopus_author_id"=>"55676828500"}, {"first_name"=>"James", "last_name"=>"Smythies", "scopus_author_id"=>"56428726200"}, {"first_name"=>"Hani", "last_name"=>"Choudhry", "scopus_author_id"=>"37004303400"}, {"first_name"=>"Margarete", "last_name"=>"Goppelt-Struebe", "scopus_author_id"=>"7006211474"}, {"first_name"=>"Peter J.", "last_name"=>"Ratcliffe", "scopus_author_id"=>"35273349500"}, {"first_name"=>"David R.", "last_name"=>"Mole", "scopus_author_id"=>"7006082609"}, {"first_name"=>"Johannes", "last_name"=>"Schödel", "scopus_author_id"=>"14039591600"}], "year"=>2017, "source"=>"PLoS Genetics", "identifiers"=>{"scopus"=>"2-s2.0-85026651387", "sgr"=>"85026651387", "doi"=>"10.1371/journal.pgen.1006872", "pui"=>"617639003", "pmid"=>"28715484", "isbn"=>"1111111111", "issn"=>"15537404"}, "id"=>"a1e1426e-36ee-3bef-9678-e118d8308416", "abstract"=>"© 2017 Grampp et al. Un-physiological activation of hypoxia inducible factor (HIF) is an early event in most renal cell cancers (RCC) following inactivation of the von Hippel-Lindau tumor suppressor. Despite intense study, how this impinges on cancer development is incompletely understood. To test for the impact of genetic signals on this pathway, we aligned human RCC-susceptibility polymorphisms with genome-wide assays of HIF-binding and observed highly significant overlap. Allele-specific assays of HIF binding, chromatin conformation and gene expression together with eQTL analyses in human tumors were applied to mechanistic analysis of one such overlapping site at chromosome 12p12.1. This defined a novel stage-specific mechanism in which the risk polymorphism, rs12814794, directly creates a new HIF-binding site that mediates HIF-1α isoform specific upregulation of its target BHLHE41. The alignment of multiple sites in the HIF cis-acting apparatus with RCC-susceptibility polymorphisms strongly supports a causal model in which minor variation in this pathway exerts significant effects on RCC development.", "link"=>"http://www.mendeley.com/research/multiple-renal-cancer-susceptibility-polymorphisms-modulate-hif-pathway", "reader_count"=>11, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>1, "Librarian"=>1, "Student > Ph. D. Student"=>2, "Student > Master"=>1, "Professor"=>1, "Unspecified"=>5}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>1, "Librarian"=>1, "Student > Ph. D. Student"=>2, "Student > Master"=>1, "Professor"=>1, "Unspecified"=>5}, "reader_count_by_subject_area"=>{"Biochemistry, Genetics and Molecular Biology"=>2, "Agricultural and Biological Sciences"=>2, "Medicine and Dentistry"=>1, "Computer Science"=>1, "Unspecified"=>5}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>2}, "Computer Science"=>{"Computer Science"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>2}, "Unspecified"=>{"Unspecified"=>5}}, "group_count"=>2}

ORCID

Scopus | Further Information

{"@_fa"=>"true", "link"=>[{"@_fa"=>"true", "@ref"=>"self", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/85026651387"}, {"@_fa"=>"true", "@ref"=>"author-affiliation", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/85026651387?field=author,affiliation"}, {"@_fa"=>"true", "@ref"=>"scopus", "@href"=>"https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85026651387&origin=inward"}, {"@_fa"=>"true", "@ref"=>"scopus-citedby", "@href"=>"https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=85026651387&origin=inward"}], "prism:url"=>"https://api.elsevier.com/content/abstract/scopus_id/85026651387", "dc:identifier"=>"SCOPUS_ID:85026651387", "eid"=>"2-s2.0-85026651387", "dc:title"=>"Multiple renal cancer susceptibility polymorphisms modulate the HIF pathway", "dc:creator"=>"Grampp S.", "prism:publicationName"=>"PLoS Genetics", "prism:issn"=>"15537390", "prism:eIssn"=>"15537404", "prism:volume"=>"13", "prism:issueIdentifier"=>"7", "prism:pageRange"=>nil, "prism:coverDate"=>"2017-07-01", "prism:coverDisplayDate"=>"July 2017", "prism:doi"=>"10.1371/journal.pgen.1006872", "citedby-count"=>"15", "affiliation"=>[{"@_fa"=>"true", "affilname"=>"Friedrich-Alexander-Universität Erlangen-Nürnberg", "affiliation-city"=>"Erlangen", "affiliation-country"=>"Germany"}], "pubmed-id"=>"28715484", "prism:aggregationType"=>"Journal", "subtype"=>"ar", "subtypeDescription"=>"Article", "article-number"=>"e1006872", "source-id"=>"4000151808", "openaccess"=>"1", "openaccessFlag"=>true, "freetoread"=>{"value"=>[{"$"=>"all"}, {"$"=>"publisherfullgold"}, {"$"=>"repository"}, {"$"=>"repositoryvor"}, {"$"=>"repositoryam"}]}, "freetoreadLabel"=>{"value"=>[{"$"=>"All Open Access"}, {"$"=>"Gold"}, {"$"=>"Green"}]}}

Web of Science®14 Apr 06:32 UTC

{"id"=>"888066368607858689", "text"=>"Ludwig's Peter Ratcliffe - new insight on how natural variations in DNA sequences influence risk for a kidney cancer https://t.co/YbcuprHzbO", "created_at"=>"2017-07-20T16:01:36Z", "user"=>"Ludwig_Cancer", "user_name"=>"Ludwig Cancer", "user_profile_image"=>"http://pbs.twimg.com/profile_images/695279538452844544/SVkSBLw6_normal.png"}

Wikipedia16 Mar 07:11 UTC

{"month"=>"7", "year"=>"2017", "pdf_views"=>"86", "xml_views"=>"8", "html_views"=>"761"}
{"month"=>"8", "year"=>"2017", "pdf_views"=>"61", "xml_views"=>"0", "html_views"=>"181"}
{"month"=>"9", "year"=>"2017", "pdf_views"=>"37", "xml_views"=>"5", "html_views"=>"117"}
{"month"=>"10", "year"=>"2017", "pdf_views"=>"17", "xml_views"=>"1", "html_views"=>"80"}
{"month"=>"11", "year"=>"2017", "pdf_views"=>"18", "xml_views"=>"0", "html_views"=>"92"}
{"month"=>"12", "year"=>"2017", "pdf_views"=>"14", "xml_views"=>"1", "html_views"=>"59"}
{"month"=>"1", "year"=>"2018", "pdf_views"=>"26", "xml_views"=>"0", "html_views"=>"41"}
{"month"=>"2", "year"=>"2018", "pdf_views"=>"15", "xml_views"=>"0", "html_views"=>"29"}
{"month"=>"3", "year"=>"2018", "pdf_views"=>"14", "xml_views"=>"0", "html_views"=>"31"}
{"month"=>"4", "year"=>"2018", "pdf_views"=>"14", "xml_views"=>"0", "html_views"=>"42"}
{"month"=>"5", "year"=>"2018", "pdf_views"=>"27", "xml_views"=>"0", "html_views"=>"20"}
{"month"=>"6", "year"=>"2018", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"22"}
{"month"=>"7", "year"=>"2018", "pdf_views"=>"5", "xml_views"=>"2", "html_views"=>"16"}
{"month"=>"8", "year"=>"2018", "pdf_views"=>"15", "xml_views"=>"1", "html_views"=>"33"}
{"month"=>"9", "year"=>"2018", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"35"}
{"month"=>"10", "year"=>"2018", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"41"}
{"month"=>"11", "year"=>"2018", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"17"}
{"month"=>"12", "year"=>"2018", "pdf_views"=>"16", "xml_views"=>"0", "html_views"=>"12"}
{"month"=>"1", "year"=>"2019", "pdf_views"=>"18", "xml_views"=>"0", "html_views"=>"25"}
{"month"=>"2", "year"=>"2019", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"15"}
{"month"=>"3", "year"=>"2019", "pdf_views"=>"17", "xml_views"=>"1", "html_views"=>"14"}
{"month"=>"4", "year"=>"2019", "pdf_views"=>"16", "xml_views"=>"0", "html_views"=>"29"}
{"month"=>"5", "year"=>"2019", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"24"}
{"month"=>"6", "year"=>"2019", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"12"}
{"month"=>"7", "year"=>"2019", "pdf_views"=>"17", "xml_views"=>"0", "html_views"=>"27"}
{"month"=>"8", "year"=>"2019", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"5"}
{"month"=>"9", "year"=>"2019", "pdf_views"=>"12", "xml_views"=>"1", "html_views"=>"32"}
{"month"=>"10", "year"=>"2019", "pdf_views"=>"55", "xml_views"=>"1", "html_views"=>"43"}
{"month"=>"11", "year"=>"2019", "pdf_views"=>"25", "xml_views"=>"1", "html_views"=>"16"}
{"month"=>"12", "year"=>"2019", "pdf_views"=>"15", "xml_views"=>"1", "html_views"=>"21"}
{"month"=>"1", "year"=>"2020", "pdf_views"=>"18", "xml_views"=>"1", "html_views"=>"21"}
{"month"=>"2", "year"=>"2020", "pdf_views"=>"9", "xml_views"=>"2", "html_views"=>"19"}
{"month"=>"3", "year"=>"2020", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"19"}
{"month"=>"4", "year"=>"2020", "pdf_views"=>"20", "xml_views"=>"0", "html_views"=>"17"}
{"month"=>"5", "year"=>"2020", "pdf_views"=>"39", "xml_views"=>"0", "html_views"=>"19"}
{"month"=>"6", "year"=>"2020", "pdf_views"=>"3", "xml_views"=>"1", "html_views"=>"11"}
{"month"=>"7", "year"=>"2020", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"16"}
{"month"=>"8", "year"=>"2020", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"19"}
{"month"=>"9", "year"=>"2020", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"8"}
{"month"=>"10", "year"=>"2020", "pdf_views"=>"11", "xml_views"=>"1", "html_views"=>"26"}
{"month"=>"11", "year"=>"2020", "pdf_views"=>"16", "xml_views"=>"0", "html_views"=>"4"}
{"month"=>"12", "year"=>"2020", "pdf_views"=>"11", "xml_views"=>"1", "html_views"=>"12"}
{"month"=>"1", "year"=>"2021", "pdf_views"=>"18", "xml_views"=>"0", "html_views"=>"6"}

Figshare

Figshare

PMC Usage Stats 80318 Jan 00:43 UTC

PMC Usage Stats

{"unique-ip"=>"44", "full-text"=>"29", "pdf"=>"26", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"8"}
{"unique-ip"=>"37", "full-text"=>"30", "pdf"=>"15", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"11", "supp-data"=>"13", "cited-by"=>"0", "year"=>"2017", "month"=>"9"}
{"unique-ip"=>"37", "full-text"=>"32", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"12", "supp-data"=>"5", "cited-by"=>"0", "year"=>"2017", "month"=>"10"}
{"unique-ip"=>"17", "full-text"=>"18", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"9", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"11"}
{"unique-ip"=>"18", "full-text"=>"19", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"10", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"12"}
{"unique-ip"=>"27", "full-text"=>"32", "pdf"=>"10", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"1"}
{"unique-ip"=>"17", "full-text"=>"14", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"3"}
{"unique-ip"=>"21", "full-text"=>"18", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"6", "cited-by"=>"0", "year"=>"2019", "month"=>"1"}
{"unique-ip"=>"36", "full-text"=>"20", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"121", "supp-data"=>"42", "cited-by"=>"0", "year"=>"2018", "month"=>"5"}
{"unique-ip"=>"17", "full-text"=>"16", "pdf"=>"7", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2018", "month"=>"4"}
{"unique-ip"=>"20", "full-text"=>"20", "pdf"=>"7", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"4", "cited-by"=>"0", "year"=>"2018", "month"=>"6"}
{"unique-ip"=>"13", "full-text"=>"12", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2018", "month"=>"7"}
{"unique-ip"=>"15", "full-text"=>"15", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"4", "cited-by"=>"0", "year"=>"2018", "month"=>"8"}
{"unique-ip"=>"17", "full-text"=>"19", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"10", "cited-by"=>"0", "year"=>"2018", "month"=>"9"}
{"unique-ip"=>"17", "full-text"=>"19", "pdf"=>"7", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"12", "cited-by"=>"0", "year"=>"2018", "month"=>"11"}
{"unique-ip"=>"26", "full-text"=>"26", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"5", "cited-by"=>"0", "year"=>"2018", "month"=>"10"}
{"unique-ip"=>"15", "full-text"=>"14", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"12"}
{"unique-ip"=>"16", "full-text"=>"18", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"9", "cited-by"=>"0", "year"=>"2019", "month"=>"2"}
{"unique-ip"=>"8", "full-text"=>"10", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2019", "month"=>"3"}
{"unique-ip"=>"16", "full-text"=>"17", "pdf"=>"8", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2019", "month"=>"4"}
{"unique-ip"=>"10", "full-text"=>"10", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"5"}
{"unique-ip"=>"18", "full-text"=>"16", "pdf"=>"6", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"10", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2019", "month"=>"8"}
{"unique-ip"=>"8", "full-text"=>"11", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"9"}
{"unique-ip"=>"27", "full-text"=>"33", "pdf"=>"6", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2019", "month"=>"10"}
{"unique-ip"=>"11", "full-text"=>"9", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"18", "cited-by"=>"0", "year"=>"2019", "month"=>"12"}
{"unique-ip"=>"15", "full-text"=>"18", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"36", "cited-by"=>"0", "year"=>"2020", "month"=>"2"}
{"unique-ip"=>"11", "full-text"=>"11", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2020", "month"=>"3"}
{"unique-ip"=>"17", "full-text"=>"16", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"11", "cited-by"=>"0", "year"=>"2020", "month"=>"4"}
{"unique-ip"=>"7", "full-text"=>"10", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"5"}
{"unique-ip"=>"14", "full-text"=>"13", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"6"}
{"unique-ip"=>"8", "full-text"=>"7", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"7"}
{"unique-ip"=>"9", "full-text"=>"6", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"8"}
{"unique-ip"=>"15", "full-text"=>"14", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2020", "month"=>"9"}
{"unique-ip"=>"16", "full-text"=>"14", "pdf"=>"7", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2020", "month"=>"10"}
{"unique-ip"=>"23", "full-text"=>"21", "pdf"=>"13", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"10", "cited-by"=>"0", "year"=>"2020", "month"=>"11"}
{"unique-ip"=>"13", "full-text"=>"8", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2020", "month"=>"12"}

Relative Metric

Relative Metric

F1000Prime20 Jan 14:26 UTC

F1000Prime

Loading …

There are currently no alerts

CiteULike

Mendeley | Further Information

ORCID

CrossRef

DataCite

Europe PMC Citations

Europe PMC Database Citations

PubMed Central

Scopus | Further Information

Web of Science®

Article Coverage

Article Coverage Curated

Facebook

Journal Comments

Nature

Reddit

Research Blogging

ScienceSeeker

Twitter

Wikipedia

Wordpress.com

Counter

Figshare

PMC Usage Stats

Relative Metric

F1000Prime