Incomplete dominance of deleterious alleles contributes substantially to trait variation and heterosis in maize
Publication Date
September 27, 2017
Authors
Jinliang Yang, Sofiane Mezmouk, Andy Baumgarten, Edward S. Buckler, et al
Volume
13
Issue
9
Pages
e1007019
DOI
https://dx.plos.org/10.1371/journal.pgen.1007019
Publisher URL
http://journals.plos.org/plosgenetics/article?id=10.1371%2Fjournal.pgen.1007019
Scopus
85031316293
Mendeley
http://www.mendeley.com/research/incomplete-dominance-deleterious-alleles-contributes-substantially-trait-variation-heterosis-maize
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Mendeley | Further Information

{"title"=>"Incomplete dominance of deleterious alleles contributes substantially to trait variation and heterosis in maize", "type"=>"journal", "authors"=>[{"first_name"=>"Jinliang", "last_name"=>"Yang", "scopus_author_id"=>"56941287000"}, {"first_name"=>"Sofiane", "last_name"=>"Mezmouk", "scopus_author_id"=>"42462046100"}, {"first_name"=>"Andy", "last_name"=>"Baumgarten", "scopus_author_id"=>"7005685629"}, {"first_name"=>"Edward S.", "last_name"=>"Buckler", "scopus_author_id"=>"6603927775"}, {"first_name"=>"Katherine E.", "last_name"=>"Guill", "scopus_author_id"=>"24073205700"}, {"first_name"=>"Michael D.", "last_name"=>"McMullen", "scopus_author_id"=>"7005444473"}, {"first_name"=>"Rita H.", "last_name"=>"Mumm", "scopus_author_id"=>"17338971700"}, {"first_name"=>"Jeffrey", "last_name"=>"Ross-Ibarra", "scopus_author_id"=>"18038149900"}], "year"=>2017, "source"=>"PLoS Genetics", "identifiers"=>{"issn"=>"15537404", "doi"=>"10.1371/journal.pgen.1007019", "sgr"=>"85031316293", "scopus"=>"2-s2.0-85031316293", "isbn"=>"1111111111", "pmid"=>"28953891", "pui"=>"618780053"}, "id"=>"81ed792d-d47f-3a2a-b3ca-19a84befe9bc", "abstract"=>"Complementation of deleterious alleles has long been proposed as a major contributor to the hybrid vigor observed in the offspring of inbred parents. We test this hypothesis using evolutionary measures of sequence conservation to ask whether incorporating information about putatively deleterious alleles can inform genomic selection (GS) models and improve phenotypic prediction. We measured a number of agronomic traits in both the inbred parents and hybrids of an elite maize partial diallel population and re-sequenced the parents of the population. Inbred elite maize lines vary for more than 500,000 putatively deleterious sites, but show less genetic load than a comparable set of inbred landraces. Our modeling reveals widespread evidence for incomplete dominance at these loci, and supports theoretical models that more damaging variants are usually more recessive. We identify haplotype blocks using an identity-by-decent (IBD) analysis and perform genomic prediction analyses in which we weight blocks on the basis of segregating putatively deleterious variants. Cross-validation results show that incorporating sequence conservation in genomic selection improves prediction accuracy for yield and several other traits as well as heterosis for those traits. Our results provide strong empirical support for an important role for incomplete dominance of deleterious alleles in explaining heterosis and demonstrate the utility of incorporating functional annotation in phenotypic prediction and plant breeding.", "link"=>"http://www.mendeley.com/research/incomplete-dominance-deleterious-alleles-contributes-substantially-trait-variation-heterosis-maize", "reader_count"=>71, "reader_count_by_academic_status"=>{"Unspecified"=>2, "Professor > Associate Professor"=>2, "Researcher"=>16, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>32, "Student > Postgraduate"=>1, "Student > Master"=>8, "Other"=>3, "Student > Bachelor"=>2, "Professor"=>4}, "reader_count_by_user_role"=>{"Unspecified"=>2, "Professor > Associate Professor"=>2, "Researcher"=>16, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>32, "Student > Postgraduate"=>1, "Student > Master"=>8, "Other"=>3, "Student > Bachelor"=>2, "Professor"=>4}, "reader_count_by_subject_area"=>{"Unspecified"=>3, "Environmental Science"=>2, "Biochemistry, Genetics and Molecular Biology"=>5, "Mathematics"=>1, "Agricultural and Biological Sciences"=>58, "Computer Science"=>1, "Earth and Planetary Sciences"=>1}, "reader_count_by_subdiscipline"=>{"Earth and Planetary Sciences"=>{"Earth and Planetary Sciences"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>58}, "Computer Science"=>{"Computer Science"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>5}, "Mathematics"=>{"Mathematics"=>1}, "Unspecified"=>{"Unspecified"=>3}, "Environmental Science"=>{"Environmental Science"=>2}}, "reader_count_by_country"=>{"United States"=>1, "France"=>1}, "group_count"=>2}

Scopus | Further Information

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