A HAD family phosphatase CSP-6 regulates the circadian output pathway in Neurospora crassa
Publication Date
January 19, 2018
Authors
Xiaoying Zhou, Bin Wang, Jillian M. Emerson, Carol S. Ringelberg, et al
Volume
14
Issue
1
Pages
e1007192
DOI
https://dx.plos.org/10.1371/journal.pgen.1007192
Publisher URL
http://journals.plos.org/plosgenetics/article?id=10.1371%2Fjournal.pgen.1007192
Scopus
85041640742
Mendeley
http://www.mendeley.com/research/family-phosphatase-csp6-regulates-circadian-output-pathway-neurospora-crassa
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Mendeley | Further Information

{"title"=>"A HAD family phosphatase CSP-6 regulates the circadian output pathway in Neurospora crassa", "type"=>"journal", "authors"=>[{"first_name"=>"Xiaoying", "last_name"=>"Zhou", "scopus_author_id"=>"56382634500"}, {"first_name"=>"Bin", "last_name"=>"Wang", "scopus_author_id"=>"56375225000"}, {"first_name"=>"Jillian M.", "last_name"=>"Emerson", "scopus_author_id"=>"56435630500"}, {"first_name"=>"Carol S.", "last_name"=>"Ringelberg", "scopus_author_id"=>"7801369734"}, {"first_name"=>"Scott A.", "last_name"=>"Gerber", "scopus_author_id"=>"34975050000"}, {"first_name"=>"Jennifer J.", "last_name"=>"Loros", "scopus_author_id"=>"7004248546"}, {"first_name"=>"Jay C.", "last_name"=>"Dunlap", "scopus_author_id"=>"26425843500"}], "year"=>2018, "source"=>"PLoS Genetics", "identifiers"=>{"sgr"=>"85041640742", "pmid"=>"PMC5800702", "pui"=>"620538972", "issn"=>"15537404", "isbn"=>"1111111111", "scopus"=>"2-s2.0-85041640742", "doi"=>"10.1371/journal.pgen.1007192"}, "id"=>"0e639662-f9e6-38b8-88e5-0d28be7f2f23", "abstract"=>"© 2018 Zhou et al. Circadian clocks are ubiquitous in eukaryotic organisms where they are used to anticipate regularly occurring diurnal and seasonal environmental changes. Nevertheless, little is known regarding pathways connecting the core clock to its output pathways. Here, we report that the HAD family phosphatase CSP-6 is required for overt circadian clock output but not for the core oscillation. The loss of function Δcsp-6 deletion mutant is overtly arrhythmic on race tubes under free running conditions; however, reporter assays confirm that the FREQUENCY-WHITE COLLAR COMPLEX core circadian oscillator is functional, indicating a discrete block between oscillator and output. CSP-6 physically interacts with WHI-2, Δwhi-2 mutant phenotypes resemble Δcsp-6, and the CSP-6/WHI-2 complex physically interacts with WC-1, all suggesting that WC-1 is a direct target for CSP-6/WHI-2-mediated dephosphorylation and consistent with observed WC-1 hyperphosphorylation in Δcsp-6. To identify the source of the block to output, known clock-co ntrolled transcription factors were screened for rhythmicity in Δcsp-6, identifying loss of circadian control of ADV-1, a direct target of WC-1, as responsible for the loss of overt rhythmicity. The CSP-6/WHI-2 complex thus participates in the clock output pathway by regulating WC-1 phosphorylation to promote proper transcriptional/translational activation of adv-1/ADV-1; these data establish an unexpected essential role for post-translational modification parallel to circadian transcriptional regulation in the early steps of circadian output.", "link"=>"http://www.mendeley.com/research/family-phosphatase-csp6-regulates-circadian-output-pathway-neurospora-crassa", "reader_count"=>5, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>1, "Researcher"=>3, "Student > Ph. D. Student"=>1}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>1, "Researcher"=>3, "Student > Ph. D. Student"=>1}, "reader_count_by_subject_area"=>{"Biochemistry, Genetics and Molecular Biology"=>3, "Agricultural and Biological Sciences"=>1, "Neuroscience"=>1}, "reader_count_by_subdiscipline"=>{"Neuroscience"=>{"Neuroscience"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>3}}, "group_count"=>0}

Scopus | Further Information

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