New insights into the transposition mechanisms of IS6110 and its dynamic distribution between Mycobacterium tuberculosis Complex lineages
Publication Date
April 12, 2018
Authors
Jesús Gonzalo Asensio, Irene Pérez, Nacho Aguiló, Santiago Uranga, et al
Volume
14
Issue
4
Pages
e1007282
DOI
https://dx.plos.org/10.1371/journal.pgen.1007282
Publisher URL
http://journals.plos.org/plosgenetics/article?id=10.1371%2Fjournal.pgen.1007282
Scopus
85046444562
Mendeley
http://www.mendeley.com/research/new-insights-transposition-mechanisms-is6110-dynamic-distribution-between-mycobacterium-tuberculosis
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Mendeley | Further Information

{"title"=>"New insights into the transposition mechanisms of IS6110 and its dynamic distribution between Mycobacterium tuberculosis Complex lineages", "type"=>"journal", "authors"=>[{"first_name"=>"Jesús", "last_name"=>"Gonzalo-Asensio"}, {"first_name"=>"Irene", "last_name"=>"Pérez"}, {"first_name"=>"Nacho", "last_name"=>"Aguiló"}, {"first_name"=>"Santiago", "last_name"=>"Uranga"}, {"first_name"=>"Ana", "last_name"=>"Picó"}, {"first_name"=>"Carlos", "last_name"=>"Lampreave"}, {"first_name"=>"Alberto", "last_name"=>"Cebollada"}, {"first_name"=>"Isabel", "last_name"=>"Otal"}, {"first_name"=>"Sofía", "last_name"=>"Samper"}, {"first_name"=>"Carlos", "last_name"=>"Martín"}], "year"=>2018, "source"=>"PLOS Genetics", "identifiers"=>{"scopus"=>"2-s2.0-85046444562", "sgr"=>"85046444562", "doi"=>"10.1371/journal.pgen.1007282", "pui"=>"622014730", "pmid"=>"29649213", "isbn"=>"1111111111", "issn"=>"1553-7404"}, "id"=>"98904019-3da8-339b-bdbf-d87f51686924", "abstract"=>"The insertion Sequence IS6110, only present in the pathogens of the Mycobacterium tuberculosis Complex (MTBC), has been the gold-standard epidemiological marker for TB for more than 25 years, but biological implications of IS6110 transposition during MTBC adaptation to humans remain elusive. By studying 2,236 clinical isolates typed by IS6110-RFLP and covering the MTBC, we remarked a lineage-specific content of IS6110 being higher in modern globally distributed strains. Once observed the IS6110 distribution in the MTBC, we selected representative isolates and found a correlation between the normalized expression of IS6110 and its abundance in MTBC chromosomes. We also studied the molecular regulation of IS6110 transposition and we found a synergistic action of two post-transcriptional mechanisms: a -1 ribosomal frameshift and a RNA pseudoknot which interferes translation. The construction of a transcriptionally active transposase resulted in 20-fold increase of the transposition frequency. Finally, we examined transposition in M. bovis and M. tuberculosis during laboratory starvation and in a mouse infection model of TB. Our results shown a higher transposition in M. tuberculosis, that preferably happens during TB infection in mice and after one year of laboratory culture, suggesting that IS6110 transposition is dynamically adapted to the host and to adverse growth conditions.", "link"=>"http://www.mendeley.com/research/new-insights-transposition-mechanisms-is6110-dynamic-distribution-between-mycobacterium-tuberculosis", "reader_count"=>17, "reader_count_by_academic_status"=>{"Unspecified"=>3, "Professor > Associate Professor"=>1, "Researcher"=>3, "Student > Ph. D. Student"=>3, "Student > Master"=>6, "Professor"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>3, "Professor > Associate Professor"=>1, "Researcher"=>3, "Student > Ph. D. Student"=>3, "Student > Master"=>6, "Professor"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>4, "Biochemistry, Genetics and Molecular Biology"=>3, "Medicine and Dentistry"=>3, "Immunology and Microbiology"=>2, "Veterinary Science and Veterinary Medicine"=>1, "Mathematics"=>1, "Agricultural and Biological Sciences"=>3}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>3}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>2}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>3}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>3}, "Mathematics"=>{"Mathematics"=>1}, "Unspecified"=>{"Unspecified"=>4}, "Veterinary Science and Veterinary Medicine"=>{"Veterinary Science and Veterinary Medicine"=>1}}, "group_count"=>0}

Scopus | Further Information

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