Selection on the regulation of sympathetic nervous activity in humans and chimpanzees
Publication Date
April 19, 2018
Authors
Kang Seon Lee, Paramita Chatterjee, Eun Young Choi, Min Kyung Sung, et al
Volume
14
Issue
4
Pages
e1007311
DOI
https://dx.plos.org/10.1371/journal.pgen.1007311
Publisher URL
http://journals.plos.org/plosgenetics/article?id=10.1371%2Fjournal.pgen.1007311
Scopus
85046418343
Mendeley
http://www.mendeley.com/research/selection-regulation-sympathetic-nervous-activity-humans-chimpanzees
Events
Loading … Spinner

Mendeley | Further Information

{"title"=>"Selection on the regulation of sympathetic nervous activity in humans and chimpanzees", "type"=>"journal", "authors"=>[{"first_name"=>"Kang Seon", "last_name"=>"Lee"}, {"first_name"=>"Paramita", "last_name"=>"Chatterjee"}, {"first_name"=>"Eun-Young", "last_name"=>"Choi"}, {"first_name"=>"Min Kyung", "last_name"=>"Sung"}, {"first_name"=>"Jaeho", "last_name"=>"Oh"}, {"first_name"=>"Hyejung", "last_name"=>"Won"}, {"first_name"=>"Seong-Min", "last_name"=>"Park"}, {"first_name"=>"Youn-Jae", "last_name"=>"Kim"}, {"first_name"=>"Soojin V.", "last_name"=>"Yi"}, {"first_name"=>"Jung Kyoon", "last_name"=>"Choi"}], "year"=>2018, "source"=>"PLOS Genetics", "identifiers"=>{"sgr"=>"85046418343", "pui"=>"622014547", "issn"=>"1553-7404", "isbn"=>"1111111111", "scopus"=>"2-s2.0-85046418343", "doi"=>"10.1371/journal.pgen.1007311"}, "id"=>"717fa5b1-9adc-3eb1-aa50-cadaa00bab20", "abstract"=>"Adrenergic α2C receptor (ADRA2C) is an inhibitory modulator of the sympathetic nervous system. Knockout mice for this gene show physiological and behavioural alterations that are associated with the fight-or-flight response. There is evidence of positive selection on the regulation of this gene during chicken domestication. Here, we find that the neuronal expression of ADRA2C is lower in human and chimpanzee than in other primates. On the basis of three-dimensional chromatin structure, we identified a cis-regulatory region whose DNA sequences have been significantly accelerated in human and chimpanzee. Active histone modification marks this region in rhesus macaque but not in human and chimpanzee; instead, repressive marks are enriched in various human brain samples. This region contains two neuron-restrictive silencer factor (NRSF) binding motifs, each of which harbours a polymorphism. Our genotyping and analysis of population genome data indicate that at both polymorphic sites, the derived allele has reached fixation in humans and chimpanzees but not in bonobos, whereas only the ancestral allele is present among macaques. Our CRISPR/Cas9 genome editing and reporter assays show that both derived nucleotides repress ADRA2C, most likely by increasing NRSF binding. In addition, we detected signatures of recent positive selection for lower neuronal ADRA2C expression in humans. Our findings indicate that there has been selective pressure for enhanced sympathetic nervous activity in the evolution of humans and chimpanzees.", "link"=>"http://www.mendeley.com/research/selection-regulation-sympathetic-nervous-activity-humans-chimpanzees", "reader_count"=>6, "reader_count_by_academic_status"=>{"Other"=>1, "Student > Ph. D. Student"=>1, "Student > Doctoral Student"=>2, "Student > Bachelor"=>1, "Student > Postgraduate"=>1}, "reader_count_by_user_role"=>{"Other"=>1, "Student > Ph. D. Student"=>1, "Student > Doctoral Student"=>2, "Student > Bachelor"=>1, "Student > Postgraduate"=>1}, "reader_count_by_subject_area"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>1, "Agricultural and Biological Sciences"=>3, "Psychology"=>1, "Biochemistry, Genetics and Molecular Biology"=>1}, "reader_count_by_subdiscipline"=>{"Psychology"=>{"Psychology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>3}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>1}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>1}}, "group_count"=>0}

Scopus | Further Information

{"@_fa"=>"true", "link"=>[{"@_fa"=>"true", "@ref"=>"self", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/85046418343"}, {"@_fa"=>"true", "@ref"=>"author-affiliation", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/85046418343?field=author,affiliation"}, {"@_fa"=>"true", "@ref"=>"scopus", "@href"=>"https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85046418343&origin=inward"}, {"@_fa"=>"true", "@ref"=>"scopus-citedby", "@href"=>"https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=85046418343&origin=inward"}], "prism:url"=>"https://api.elsevier.com/content/abstract/scopus_id/85046418343", "dc:identifier"=>"SCOPUS_ID:85046418343", "eid"=>"2-s2.0-85046418343", "dc:title"=>"Selection on the regulation of sympathetic nervous activity in humans and chimpanzees", "dc:creator"=>"Lee K.", "prism:publicationName"=>"PLoS Genetics", "prism:issn"=>"15537390", "prism:eIssn"=>"15537404", "prism:volume"=>"14", "prism:issueIdentifier"=>"4", "prism:pageRange"=>nil, "prism:coverDate"=>"2018-04-01", "prism:coverDisplayDate"=>"April 2018", "prism:doi"=>"10.1371/journal.pgen.1007311", "citedby-count"=>"1", "affiliation"=>[{"@_fa"=>"true", "affilname"=>"Korea Advanced Institute of Science & Technology", "affiliation-city"=>"Yusong", "affiliation-country"=>"South Korea"}], "pubmed-id"=>"29672586", "prism:aggregationType"=>"Journal", "subtype"=>"ar", "subtypeDescription"=>"Article", "article-number"=>"e1007311", "source-id"=>"4000151808", "openaccess"=>"1", "openaccessFlag"=>true}

Counter

  • {"month"=>"4", "year"=>"2018", "pdf_views"=>"325", "xml_views"=>"796", "html_views"=>"758"}
  • {"month"=>"5", "year"=>"2018", "pdf_views"=>"115", "xml_views"=>"329", "html_views"=>"250"}
  • {"month"=>"6", "year"=>"2018", "pdf_views"=>"29", "xml_views"=>"1", "html_views"=>"66"}
  • {"month"=>"7", "year"=>"2018", "pdf_views"=>"31", "xml_views"=>"1", "html_views"=>"55"}
  • {"month"=>"8", "year"=>"2018", "pdf_views"=>"21", "xml_views"=>"1", "html_views"=>"46"}
  • {"month"=>"9", "year"=>"2018", "pdf_views"=>"19", "xml_views"=>"0", "html_views"=>"45"}
  • {"month"=>"10", "year"=>"2018", "pdf_views"=>"38", "xml_views"=>"0", "html_views"=>"47"}
  • {"month"=>"11", "year"=>"2018", "pdf_views"=>"30", "xml_views"=>"0", "html_views"=>"80"}
  • {"month"=>"12", "year"=>"2018", "pdf_views"=>"33", "xml_views"=>"0", "html_views"=>"61"}
  • {"month"=>"1", "year"=>"2019", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"62"}
  • {"month"=>"2", "year"=>"2019", "pdf_views"=>"20", "xml_views"=>"3", "html_views"=>"43"}
  • {"month"=>"3", "year"=>"2019", "pdf_views"=>"26", "xml_views"=>"2", "html_views"=>"70"}
  • {"month"=>"4", "year"=>"2019", "pdf_views"=>"18", "xml_views"=>"1", "html_views"=>"40"}
  • {"month"=>"5", "year"=>"2019", "pdf_views"=>"26", "xml_views"=>"0", "html_views"=>"30"}

PMC Usage Stats

  • {"unique-ip"=>"9", "full-text"=>"8", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2019", "month"=>"1"}
  • {"unique-ip"=>"29", "full-text"=>"27", "pdf"=>"7", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"9", "cited-by"=>"0", "year"=>"2018", "month"=>"5"}
  • {"unique-ip"=>"28", "full-text"=>"21", "pdf"=>"6", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"21", "cited-by"=>"0", "year"=>"2018", "month"=>"6"}
  • {"unique-ip"=>"24", "full-text"=>"14", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"9", "supp-data"=>"8", "cited-by"=>"0", "year"=>"2018", "month"=>"7"}
  • {"unique-ip"=>"18", "full-text"=>"16", "pdf"=>"7", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2018", "month"=>"8"}
  • {"unique-ip"=>"17", "full-text"=>"15", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2018", "month"=>"9"}
  • {"unique-ip"=>"12", "full-text"=>"14", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"10"}
  • {"unique-ip"=>"43", "full-text"=>"10", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"49", "cited-by"=>"0", "year"=>"2018", "month"=>"11"}
  • {"unique-ip"=>"22", "full-text"=>"24", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"4", "cited-by"=>"0", "year"=>"2018", "month"=>"12"}
  • {"unique-ip"=>"9", "full-text"=>"9", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2019", "month"=>"2"}
  • {"unique-ip"=>"9", "full-text"=>"12", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"3"}
  • {"unique-ip"=>"5", "full-text"=>"7", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"4"}
Loading … Spinner
There are currently no alerts