Estimation of the Total Parasite Biomass in Acute Falciparum Malaria from Plasma PfHRP2
Publication Date
August 23, 2005
Journal
PLOS Medicine
Authors
Arjen M Dondorp, Varunee Desakorn, Wirichada Pongtavornpinyo, Duangjai Sahassananda, et al
Volume
2
Issue
8
Pages
e204
DOI
https://dx.plos.org/10.1371/journal.pmed.0020204
Publisher URL
http://journals.plos.org/plosmedicine/article?id=10.1371%2Fjournal.pmed.0020204
PubMed
http://www.ncbi.nlm.nih.gov/pubmed/16104831
PubMed Central
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1188247
Europe PMC
http://europepmc.org/abstract/MED/16104831
Web of Science
000231676900026
Scopus
33846043474
Mendeley
http://www.mendeley.com/research/estimation-total-parasite-biomass-acute-falciparum-malaria-plasma-pfhrp2
Events
Loading … Spinner

Mendeley | Further Information

{"title"=>"Estimation of the total parasite biomass in acute falciparum malaria from plasma PfHRP2", "type"=>"journal", "authors"=>[{"first_name"=>"Arjen M.", "last_name"=>"Dondorp", "scopus_author_id"=>"35462577600"}, {"first_name"=>"Varunee", "last_name"=>"Desakorn", "scopus_author_id"=>"6603980280"}, {"first_name"=>"Wirichada", "last_name"=>"Pongtavornpinyo", "scopus_author_id"=>"36739433600"}, {"first_name"=>"Duangjai", "last_name"=>"Sahassananda", "scopus_author_id"=>"6507542754"}, {"first_name"=>"Kamolrat", "last_name"=>"Silamut", "scopus_author_id"=>"6701561191"}, {"first_name"=>"Kesinee", "last_name"=>"Chotivanich", "scopus_author_id"=>"55979038200"}, {"first_name"=>"Paul N.", "last_name"=>"Newton", "scopus_author_id"=>"7103312945"}, {"first_name"=>"Punnee", "last_name"=>"Pitisuttithum", "scopus_author_id"=>"7004614312"}, {"first_name"=>"A. M.", "last_name"=>"Smithyman", "scopus_author_id"=>"56631329500"}, {"first_name"=>"Nicholas J.", "last_name"=>"White", "scopus_author_id"=>"7401767314"}, {"first_name"=>"Nicholas P.J.", "last_name"=>"Day", "scopus_author_id"=>"36071528500"}], "year"=>2005, "source"=>"PLoS Medicine", "identifiers"=>{"scopus"=>"2-s2.0-33846043474", "sgr"=>"33846043474", "issn"=>"15491277", "doi"=>"10.1371/journal.pmed.0020204", "pmid"=>"16104831", "isbn"=>"1549-1676 (Electronic)\\r1549-1277 (Linking)", "pui"=>"46179250"}, "id"=>"ee09c17d-70d5-39cd-bce0-8d2d14d0f299", "abstract"=>"BACKGROUND: In falciparum malaria sequestration of erythrocytes containing mature forms of Plasmodium falciparum in the microvasculature of vital organs is central to pathology, but quantitation of this hidden sequestered parasite load in vivo has not previously been possible. The peripheral blood parasite count measures only the circulating, relatively non-pathogenic parasite numbers. P. falciparum releases a specific histidine-rich protein (PfHRP2) into plasma. Quantitative measurement of plasma PfHRP2 concentrations may reflect the total parasite biomass in falciparum malaria.\\n\\nMETHODS AND FINDINGS: We measured plasma concentrations of PfHRP2, using a quantitative antigen-capture enzyme-linked immunosorbent assay, in 337 adult patients with falciparum malaria of varying severity hospitalised on the Thai-Burmese border. Based on in vitro production rates, we constructed a model to link this measure to the total parasite burden in the patient. The estimated geometric mean parasite burden was 7 x 10(11) (95% confidence interval [CI] 5.8 x 10(11) to 8.5 x 10(11)) parasites per body, and was over six times higher in severe malaria (geometric mean 1.7 x 10(12), 95% CI 1.3 x 10(12) to 2.3 x 10(12)) than in patients hospitalised without signs of severity (geometric mean 2.8 x 10(11), 95% CI 2.3 x 10(11) to 3.5 x 10(11); p < 0.001). Parasite burden was highest in patients who died (geometric mean 3.4 x 10(12), 95% CI 1.9 x 10(12) to 6.3 x 10(12); p = 0.03). The calculated number of sequestered parasites increased with disease severity and was higher in patients with late developmental stages of P. falciparum present on peripheral blood smears. Comparing model and laboratory estimates of the time of sequestration suggested that admission to hospital with uncomplicated malaria often follows schizogony-but in severe malaria is unrelated to stage of parasite development.\\n\\nCONCLUSION: Plasma PfHRP2 concentrations may be used to estimate the total body parasite biomass in acute falciparum malaria. Severe malaria results from extensive sequestration of parasitised erythrocytes.", "link"=>"http://www.mendeley.com/research/estimation-total-parasite-biomass-acute-falciparum-malaria-plasma-pfhrp2", "reader_count"=>166, "reader_count_by_academic_status"=>{"Unspecified"=>3, "Professor > Associate Professor"=>6, "Librarian"=>1, "Researcher"=>35, "Student > Doctoral Student"=>15, "Student > Ph. D. Student"=>43, "Student > Postgraduate"=>7, "Student > Master"=>23, "Other"=>8, "Student > Bachelor"=>12, "Professor"=>13}, "reader_count_by_user_role"=>{"Unspecified"=>3, "Professor > Associate Professor"=>6, "Librarian"=>1, "Researcher"=>35, "Student > Doctoral Student"=>15, "Student > Ph. D. Student"=>43, "Student > Postgraduate"=>7, "Student > Master"=>23, "Other"=>8, "Student > Bachelor"=>12, "Professor"=>13}, "reader_count_by_subject_area"=>{"Unspecified"=>9, "Agricultural and Biological Sciences"=>61, "Business, Management and Accounting"=>1, "Veterinary Science and Veterinary Medicine"=>1, "Chemical Engineering"=>2, "Chemistry"=>5, "Economics, Econometrics and Finance"=>1, "Engineering"=>11, "Environmental Science"=>2, "Biochemistry, Genetics and Molecular Biology"=>7, "Nursing and Health Professions"=>2, "Mathematics"=>2, "Medicine and Dentistry"=>43, "Pharmacology, Toxicology and Pharmaceutical Science"=>6, "Physics and Astronomy"=>2, "Immunology and Microbiology"=>11}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>43}, "Physics and Astronomy"=>{"Physics and Astronomy"=>2}, "Mathematics"=>{"Mathematics"=>2}, "Unspecified"=>{"Unspecified"=>9}, "Environmental Science"=>{"Environmental Science"=>2}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>6}, "Chemical Engineering"=>{"Chemical Engineering"=>2}, "Engineering"=>{"Engineering"=>11}, "Chemistry"=>{"Chemistry"=>5}, "Economics, Econometrics and Finance"=>{"Economics, Econometrics and Finance"=>1}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>11}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>61}, "Business, Management and Accounting"=>{"Business, Management and Accounting"=>1}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>2}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>7}, "Veterinary Science and Veterinary Medicine"=>{"Veterinary Science and Veterinary Medicine"=>1}}, "reader_count_by_country"=>{"Ecuador"=>1, "United States"=>2, "Tanzania"=>1, "United Kingdom"=>2, "Malaysia"=>1, "Thailand"=>1, "Switzerland"=>1, "India"=>2, "Spain"=>1, "Canada"=>1, "Belgium"=>1, "China"=>1, "Brazil"=>3, "South Africa"=>1, "France"=>1}, "group_count"=>9}

CrossRef

Scopus | Further Information

{"@_fa"=>"true", "link"=>[{"@_fa"=>"true", "@ref"=>"self", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/33846043474"}, {"@_fa"=>"true", "@ref"=>"author-affiliation", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/33846043474?field=author,affiliation"}, {"@_fa"=>"true", "@ref"=>"scopus", "@href"=>"https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=33846043474&origin=inward"}, {"@_fa"=>"true", "@ref"=>"scopus-citedby", "@href"=>"https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=33846043474&origin=inward"}], "prism:url"=>"https://api.elsevier.com/content/abstract/scopus_id/33846043474", "dc:identifier"=>"SCOPUS_ID:33846043474", "eid"=>"2-s2.0-33846043474", "dc:title"=>"Estimation of the total parasite biomass in acute falciparum malaria from plasma PfHRP2", "dc:creator"=>"Dondorp A.", "prism:publicationName"=>"PLoS Medicine", "prism:issn"=>"15491277", "prism:eIssn"=>"15491676", "prism:volume"=>"2", "prism:issueIdentifier"=>"8", "prism:pageRange"=>"0788-0797", "prism:coverDate"=>"2005-12-01", "prism:coverDisplayDate"=>"2005", "prism:doi"=>"10.1371/journal.pmed.0020204", "citedby-count"=>"267", "affiliation"=>[{"@_fa"=>"true", "affilname"=>"Churchill Hospital", "affiliation-city"=>"Oxford", "affiliation-country"=>"United Kingdom"}, {"@_fa"=>"true", "affilname"=>"Mahidol University", "affiliation-city"=>"Nakhon Pathom", "affiliation-country"=>"Thailand"}], "pubmed-id"=>"16104831", "prism:aggregationType"=>"Journal", "subtype"=>"ar", "subtypeDescription"=>"Article", "source-id"=>"144840", "openaccess"=>"1", "openaccessFlag"=>true}

Facebook

  • {"url"=>"http%3A%2F%2Fjournals.plos.org%2Fplosmedicine%2Farticle%3Fid%3D10.1371%252Fjournal.pmed.0020204", "share_count"=>0, "like_count"=>0, "comment_count"=>0, "click_count"=>0, "total_count"=>0}

Journal Comments | Further Information

Counter

  • {"month"=>"8", "year"=>"2005", "pdf_views"=>"133", "xml_views"=>"2", "html_views"=>"265"}
  • {"month"=>"9", "year"=>"2005", "pdf_views"=>"89", "xml_views"=>"0", "html_views"=>"219"}
  • {"month"=>"10", "year"=>"2005", "pdf_views"=>"31", "xml_views"=>"0", "html_views"=>"53"}
  • {"month"=>"11", "year"=>"2005", "pdf_views"=>"48", "xml_views"=>"0", "html_views"=>"137"}
  • {"month"=>"12", "year"=>"2005", "pdf_views"=>"28", "xml_views"=>"1", "html_views"=>"98"}
  • {"month"=>"1", "year"=>"2006", "pdf_views"=>"28", "xml_views"=>"0", "html_views"=>"82"}
  • {"month"=>"2", "year"=>"2006", "pdf_views"=>"16", "xml_views"=>"0", "html_views"=>"76"}
  • {"month"=>"3", "year"=>"2006", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"80"}
  • {"month"=>"4", "year"=>"2006", "pdf_views"=>"15", "xml_views"=>"1", "html_views"=>"66"}
  • {"month"=>"5", "year"=>"2006", "pdf_views"=>"9", "xml_views"=>"1", "html_views"=>"62"}
  • {"month"=>"6", "year"=>"2006", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"52"}
  • {"month"=>"7", "year"=>"2006", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"34"}
  • {"month"=>"8", "year"=>"2006", "pdf_views"=>"23", "xml_views"=>"2", "html_views"=>"77"}
  • {"month"=>"9", "year"=>"2006", "pdf_views"=>"15", "xml_views"=>"0", "html_views"=>"37"}
  • {"month"=>"10", "year"=>"2006", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"44"}
  • {"month"=>"11", "year"=>"2006", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"45"}
  • {"month"=>"12", "year"=>"2006", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"35"}
  • {"month"=>"1", "year"=>"2007", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"56"}
  • {"month"=>"2", "year"=>"2007", "pdf_views"=>"6", "xml_views"=>"2", "html_views"=>"38"}
  • {"month"=>"3", "year"=>"2007", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"25"}
  • {"month"=>"4", "year"=>"2007", "pdf_views"=>"10", "xml_views"=>"4", "html_views"=>"37"}
  • {"month"=>"5", "year"=>"2007", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"50"}
  • {"month"=>"6", "year"=>"2007", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"35"}
  • {"month"=>"7", "year"=>"2007", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"38"}
  • {"month"=>"8", "year"=>"2007", "pdf_views"=>"9", "xml_views"=>"1", "html_views"=>"18"}
  • {"month"=>"9", "year"=>"2007", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"10"}
  • {"month"=>"10", "year"=>"2007", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"20"}
  • {"month"=>"11", "year"=>"2007", "pdf_views"=>"5", "xml_views"=>"1", "html_views"=>"30"}
  • {"month"=>"12", "year"=>"2007", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"30"}
  • {"month"=>"1", "year"=>"2008", "pdf_views"=>"8", "xml_views"=>"7", "html_views"=>"31"}
  • {"month"=>"2", "year"=>"2008", "pdf_views"=>"10", "xml_views"=>"3", "html_views"=>"52"}
  • {"month"=>"3", "year"=>"2008", "pdf_views"=>"7", "xml_views"=>"4", "html_views"=>"26"}
  • {"month"=>"4", "year"=>"2008", "pdf_views"=>"8", "xml_views"=>"1", "html_views"=>"28"}
  • {"month"=>"5", "year"=>"2008", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"35"}
  • {"month"=>"6", "year"=>"2008", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"48"}
  • {"month"=>"7", "year"=>"2008", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"40"}
  • {"month"=>"8", "year"=>"2008", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"58"}
  • {"month"=>"9", "year"=>"2008", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"54"}
  • {"month"=>"10", "year"=>"2008", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"32"}
  • {"month"=>"11", "year"=>"2008", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"28"}
  • {"month"=>"12", "year"=>"2008", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"24"}
  • {"month"=>"1", "year"=>"2009", "pdf_views"=>"9", "xml_views"=>"1", "html_views"=>"27"}
  • {"month"=>"2", "year"=>"2009", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"28"}
  • {"month"=>"3", "year"=>"2009", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"26"}
  • {"month"=>"4", "year"=>"2009", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"14"}
  • {"month"=>"5", "year"=>"2009", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"15"}
  • {"month"=>"6", "year"=>"2009", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"25"}
  • {"month"=>"7", "year"=>"2009", "pdf_views"=>"10", "xml_views"=>"1", "html_views"=>"37"}
  • {"month"=>"8", "year"=>"2009", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"25"}
  • {"month"=>"9", "year"=>"2009", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"38"}
  • {"month"=>"10", "year"=>"2009", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"40"}
  • {"month"=>"11", "year"=>"2009", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"31"}
  • {"month"=>"12", "year"=>"2009", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"21"}
  • {"month"=>"1", "year"=>"2010", "pdf_views"=>"7", "xml_views"=>"3", "html_views"=>"24"}
  • {"month"=>"2", "year"=>"2010", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"29"}
  • {"month"=>"3", "year"=>"2010", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"41"}
  • {"month"=>"4", "year"=>"2010", "pdf_views"=>"9", "xml_views"=>"6", "html_views"=>"45"}
  • {"month"=>"5", "year"=>"2010", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"40"}
  • {"month"=>"6", "year"=>"2010", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"71"}
  • {"month"=>"7", "year"=>"2010", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"34"}
  • {"month"=>"8", "year"=>"2010", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"34"}
  • {"month"=>"9", "year"=>"2010", "pdf_views"=>"8", "xml_views"=>"1", "html_views"=>"40"}
  • {"month"=>"10", "year"=>"2010", "pdf_views"=>"11", "xml_views"=>"3", "html_views"=>"32"}
  • {"month"=>"11", "year"=>"2010", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"39"}
  • {"month"=>"12", "year"=>"2010", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"27"}
  • {"month"=>"1", "year"=>"2011", "pdf_views"=>"6", "xml_views"=>"4", "html_views"=>"20"}
  • {"month"=>"2", "year"=>"2011", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"32"}
  • {"month"=>"3", "year"=>"2011", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"21"}
  • {"month"=>"4", "year"=>"2011", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"43"}
  • {"month"=>"5", "year"=>"2011", "pdf_views"=>"9", "xml_views"=>"1", "html_views"=>"30"}
  • {"month"=>"6", "year"=>"2011", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"26"}
  • {"month"=>"7", "year"=>"2011", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"33"}
  • {"month"=>"8", "year"=>"2011", "pdf_views"=>"5", "xml_views"=>"3", "html_views"=>"35"}
  • {"month"=>"9", "year"=>"2011", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"44"}
  • {"month"=>"10", "year"=>"2011", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"41"}
  • {"month"=>"11", "year"=>"2011", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"35"}
  • {"month"=>"12", "year"=>"2011", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"41"}
  • {"month"=>"1", "year"=>"2012", "pdf_views"=>"13", "xml_views"=>"1", "html_views"=>"40"}
  • {"month"=>"2", "year"=>"2012", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"44"}
  • {"month"=>"3", "year"=>"2012", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"37"}
  • {"month"=>"4", "year"=>"2012", "pdf_views"=>"18", "xml_views"=>"3", "html_views"=>"65"}
  • {"month"=>"5", "year"=>"2012", "pdf_views"=>"15", "xml_views"=>"2", "html_views"=>"70"}
  • {"month"=>"6", "year"=>"2012", "pdf_views"=>"9", "xml_views"=>"1", "html_views"=>"65"}
  • {"month"=>"7", "year"=>"2012", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"51"}
  • {"month"=>"8", "year"=>"2012", "pdf_views"=>"12", "xml_views"=>"6", "html_views"=>"85"}
  • {"month"=>"9", "year"=>"2012", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"43"}
  • {"month"=>"10", "year"=>"2012", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"51"}
  • {"month"=>"11", "year"=>"2012", "pdf_views"=>"14", "xml_views"=>"0", "html_views"=>"43"}
  • {"month"=>"12", "year"=>"2012", "pdf_views"=>"2", "xml_views"=>"2", "html_views"=>"31"}
  • {"month"=>"1", "year"=>"2013", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"83"}
  • {"month"=>"2", "year"=>"2013", "pdf_views"=>"13", "xml_views"=>"2", "html_views"=>"49"}
  • {"month"=>"3", "year"=>"2013", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"75"}
  • {"month"=>"4", "year"=>"2013", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"86"}
  • {"month"=>"5", "year"=>"2013", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"116"}
  • {"month"=>"6", "year"=>"2013", "pdf_views"=>"8", "xml_views"=>"1", "html_views"=>"74"}
  • {"month"=>"7", "year"=>"2013", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"48"}
  • {"month"=>"8", "year"=>"2013", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"65"}
  • {"month"=>"9", "year"=>"2013", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"92"}
  • {"month"=>"10", "year"=>"2013", "pdf_views"=>"11", "xml_views"=>"1", "html_views"=>"97"}
  • {"month"=>"11", "year"=>"2013", "pdf_views"=>"14", "xml_views"=>"3", "html_views"=>"84"}
  • {"month"=>"12", "year"=>"2013", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"54"}
  • {"month"=>"1", "year"=>"2014", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"50"}
  • {"month"=>"2", "year"=>"2014", "pdf_views"=>"11", "xml_views"=>"1", "html_views"=>"59"}
  • {"month"=>"3", "year"=>"2014", "pdf_views"=>"16", "xml_views"=>"2", "html_views"=>"101"}
  • {"month"=>"4", "year"=>"2014", "pdf_views"=>"2", "xml_views"=>"2", "html_views"=>"74"}
  • {"month"=>"5", "year"=>"2014", "pdf_views"=>"13", "xml_views"=>"1", "html_views"=>"100"}
  • {"month"=>"6", "year"=>"2014", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"82"}
  • {"month"=>"7", "year"=>"2014", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"70"}
  • {"month"=>"8", "year"=>"2014", "pdf_views"=>"11", "xml_views"=>"3", "html_views"=>"50"}
  • {"month"=>"9", "year"=>"2014", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"68"}
  • {"month"=>"10", "year"=>"2014", "pdf_views"=>"15", "xml_views"=>"2", "html_views"=>"88"}
  • {"month"=>"11", "year"=>"2014", "pdf_views"=>"4", "xml_views"=>"1", "html_views"=>"38"}
  • {"month"=>"12", "year"=>"2014", "pdf_views"=>"9", "xml_views"=>"2", "html_views"=>"85"}
  • {"month"=>"1", "year"=>"2015", "pdf_views"=>"22", "xml_views"=>"0", "html_views"=>"93"}
  • {"month"=>"2", "year"=>"2015", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"46"}
  • {"month"=>"3", "year"=>"2015", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"38"}
  • {"month"=>"4", "year"=>"2015", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"52"}
  • {"month"=>"5", "year"=>"2015", "pdf_views"=>"10", "xml_views"=>"1", "html_views"=>"61"}
  • {"month"=>"6", "year"=>"2015", "pdf_views"=>"14", "xml_views"=>"0", "html_views"=>"67"}
  • {"month"=>"7", "year"=>"2015", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"48"}
  • {"month"=>"8", "year"=>"2015", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"50"}
  • {"month"=>"9", "year"=>"2015", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"38"}
  • {"month"=>"10", "year"=>"2015", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"37"}
  • {"month"=>"11", "year"=>"2015", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"27"}
  • {"month"=>"12", "year"=>"2015", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"40"}
  • {"month"=>"1", "year"=>"2016", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"38"}
  • {"month"=>"2", "year"=>"2016", "pdf_views"=>"23", "xml_views"=>"1", "html_views"=>"50"}
  • {"month"=>"3", "year"=>"2016", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"47"}
  • {"month"=>"4", "year"=>"2016", "pdf_views"=>"14", "xml_views"=>"0", "html_views"=>"53"}
  • {"month"=>"5", "year"=>"2016", "pdf_views"=>"15", "xml_views"=>"0", "html_views"=>"35"}
  • {"month"=>"6", "year"=>"2016", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"39"}
  • {"month"=>"7", "year"=>"2016", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"48"}
  • {"month"=>"8", "year"=>"2016", "pdf_views"=>"14", "xml_views"=>"0", "html_views"=>"70"}
  • {"month"=>"9", "year"=>"2016", "pdf_views"=>"19", "xml_views"=>"0", "html_views"=>"65"}
  • {"month"=>"10", "year"=>"2016", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"50"}
  • {"month"=>"11", "year"=>"2016", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"39"}
  • {"month"=>"12", "year"=>"2016", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"43"}
  • {"month"=>"1", "year"=>"2017", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"54"}
  • {"month"=>"2", "year"=>"2017", "pdf_views"=>"14", "xml_views"=>"0", "html_views"=>"61"}
  • {"month"=>"3", "year"=>"2017", "pdf_views"=>"14", "xml_views"=>"0", "html_views"=>"51"}
  • {"month"=>"4", "year"=>"2017", "pdf_views"=>"15", "xml_views"=>"1", "html_views"=>"63"}
  • {"month"=>"5", "year"=>"2017", "pdf_views"=>"10", "xml_views"=>"1", "html_views"=>"42"}
  • {"month"=>"6", "year"=>"2017", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"54"}
  • {"month"=>"7", "year"=>"2017", "pdf_views"=>"17", "xml_views"=>"1", "html_views"=>"59"}
  • {"month"=>"8", "year"=>"2017", "pdf_views"=>"8", "xml_views"=>"2", "html_views"=>"40"}
  • {"month"=>"9", "year"=>"2017", "pdf_views"=>"8", "xml_views"=>"1", "html_views"=>"48"}
  • {"month"=>"10", "year"=>"2017", "pdf_views"=>"13", "xml_views"=>"2", "html_views"=>"48"}
  • {"month"=>"11", "year"=>"2017", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"61"}
  • {"month"=>"12", "year"=>"2017", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"53"}
  • {"month"=>"1", "year"=>"2018", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"39"}
  • {"month"=>"2", "year"=>"2018", "pdf_views"=>"18", "xml_views"=>"1", "html_views"=>"34"}
  • {"month"=>"3", "year"=>"2018", "pdf_views"=>"9", "xml_views"=>"1", "html_views"=>"29"}
  • {"month"=>"4", "year"=>"2018", "pdf_views"=>"21", "xml_views"=>"0", "html_views"=>"38"}
  • {"month"=>"5", "year"=>"2018", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"25"}
  • {"month"=>"6", "year"=>"2018", "pdf_views"=>"12", "xml_views"=>"4", "html_views"=>"27"}
  • {"month"=>"7", "year"=>"2018", "pdf_views"=>"12", "xml_views"=>"5", "html_views"=>"30"}
  • {"month"=>"8", "year"=>"2018", "pdf_views"=>"20", "xml_views"=>"1", "html_views"=>"22"}
  • {"month"=>"9", "year"=>"2018", "pdf_views"=>"21", "xml_views"=>"1", "html_views"=>"34"}
  • {"month"=>"10", "year"=>"2018", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"32"}
  • {"month"=>"11", "year"=>"2018", "pdf_views"=>"15", "xml_views"=>"0", "html_views"=>"30"}
  • {"month"=>"12", "year"=>"2018", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"18"}
  • {"month"=>"1", "year"=>"2019", "pdf_views"=>"23", "xml_views"=>"0", "html_views"=>"25"}
  • {"month"=>"2", "year"=>"2019", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"17"}
  • {"month"=>"3", "year"=>"2019", "pdf_views"=>"11", "xml_views"=>"1", "html_views"=>"16"}
  • {"month"=>"4", "year"=>"2019", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"25"}
  • {"month"=>"5", "year"=>"2019", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"38"}
  • {"month"=>"6", "year"=>"2019", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"17"}
  • {"month"=>"7", "year"=>"2019", "pdf_views"=>"19", "xml_views"=>"1", "html_views"=>"28"}
  • {"month"=>"8", "year"=>"2019", "pdf_views"=>"19", "xml_views"=>"0", "html_views"=>"15"}
  • {"month"=>"9", "year"=>"2019", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"26"}
  • {"month"=>"10", "year"=>"2019", "pdf_views"=>"18", "xml_views"=>"1", "html_views"=>"17"}
  • {"month"=>"11", "year"=>"2019", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"11"}

Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/474705", "https://ndownloader.figshare.com/files/474751"], "description"=>"<div><h3>Background</h3><p>In falciparum malaria sequestration of erythrocytes containing mature forms of <em>Plasmodium falciparum</em> in the microvasculature of vital organs is central to pathology, but quantitation of this hidden sequestered parasite load in vivo has not previously been possible. The peripheral blood parasite count measures only the circulating, relatively non-pathogenic parasite numbers. <em>P. falciparum</em> releases a specific histidine-rich protein (PfHRP2) into plasma. Quantitative measurement of plasma PfHRP2 concentrations may reflect the total parasite biomass in falciparum malaria.</p> <h3>Methods and Findings</h3><p>We measured plasma concentrations of PfHRP2, using a quantitative antigen-capture enzyme-linked immunosorbent assay, in 337 adult patients with falciparum malaria of varying severity hospitalised on the Thai–Burmese border. Based on in vitro production rates, we constructed a model to link this measure to the total parasite burden in the patient. The estimated geometric mean parasite burden was 7 × 10<sup>11</sup> (95% confidence interval [CI] 5.8 × 10<sup>11</sup> to 8.5 × 10<sup>11</sup>) parasites per body, and was over six times higher in severe malaria (geometric mean 1.7 × 10<sup>12</sup>, 95% CI 1.3 × 10<sup>12</sup> to 2.3 × 10<sup>12</sup>) than in patients hospitalised without signs of severity (geometric mean 2.8 × 10<sup>11</sup>, 95% CI 2.3 × 10<sup>11</sup> to 3.5 × 10<sup>11</sup>; <em>p</em> < 0.001). Parasite burden was highest in patients who died (geometric mean 3.4 × 10<sup>12</sup>, 95% CI 1.9 × 10<sup>12</sup> to 6.3 × 10<sup>12</sup>; <em>p</em> = 0.03). The calculated number of sequestered parasites increased with disease severity and was higher in patients with late developmental stages of <em>P. falciparum</em> present on peripheral blood smears. Comparing model and laboratory estimates of the time of sequestration suggested that admission to hospital with uncomplicated malaria often follows schizogony—but in severe malaria is unrelated to stage of parasite development.</p> <h3>Conclusion</h3><p>Plasma PfHRP2 concentrations may be used to estimate the total body parasite biomass in acute falciparum malaria. Severe malaria results from extensive sequestration of parasitised erythrocytes.</p> </div>", "links"=>[], "tags"=>["estimation", "parasite", "biomass", "acute", "falciparum", "malaria", "plasma", "pfhrp2"], "article_id"=>153569, "categories"=>["Cancer"], "users"=>["Arjen M Dondorp", "Varunee Desakorn", "Wirichada Pongtavornpinyo", "Duangjai Sahassananda", "Kamolrat Silamut", "Kesinee Chotivanich", "Paul N Newton", "Punnee Pitisuttithum", "A. M Smithyman", "Nicholas J White", "Nicholas P. J Day"], "doi"=>["https://dx.doi.org/10.1371/journal.pmed.0020204.sg001", "https://dx.doi.org/10.1371/journal.pmed.0020204.sg002"], "stats"=>{"downloads"=>11, "page_views"=>19, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Estimation_of_the_Total_Parasite_Biomass_in_Acute_Falciparum_Malaria_from_Plasma_PfHRP2/153569", "title"=>"Estimation of the Total Parasite Biomass in Acute Falciparum Malaria from Plasma PfHRP2", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2013-01-20 13:37:16"}
  • {"files"=>["https://ndownloader.figshare.com/files/961423"], "description"=>"<p>Total PfHRP2 derives from the amount produced by the generation present in that cycle and the amount produced at schizont rupture of the previous cycle (broken lines). The concentration accumulated from previous production is added to this (black lines). PfHRP2 produced in previous cycles will decline over time (dotted lines). Values chosen for the parameters in this illustration were as follows: Hct, 0.35; body weight, 50 kg; and parasite multiplication factor, eight.</p>", "links"=>[], "tags"=>["describing", "pfhrp2", "derived", "parasites"], "article_id"=>631402, "categories"=>["Infectious Diseases"], "users"=>["Arjen M Dondorp", "Varunee Desakorn", "Wirichada Pongtavornpinyo", "Duangjai Sahassananda", "Kamolrat Silamut", "Kesinee Chotivanich", "Paul N Newton", "Punnee Pitisuttithum", "A. M Smithyman", "Nicholas J White", "Nicholas P. J Day"], "doi"=>"https://dx.doi.org/10.1371/journal.pmed.0020204.g001", "stats"=>{"downloads"=>0, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Model_Describing_the_PfHRP2_Concentration_Derived_from_10_12_Total_Body_Parasites_in_the_Last_Cycle_/631402", "title"=>"Model Describing the PfHRP2 Concentration Derived from 10<sup>12</sup> Total Body Parasites in the Last Cycle", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-22 08:57:00"}
  • {"files"=>["https://ndownloader.figshare.com/files/961525"], "description"=>"<p>Values chosen for the parameters were as follows: PfHRP2 concentration, 1,000 μg/l; Hct, 0.35; and body weight, 50 kg.</p>", "links"=>[], "tags"=>["parasite", "biomass", "multiplication"], "article_id"=>631507, "categories"=>["Infectious Diseases"], "users"=>["Arjen M Dondorp", "Varunee Desakorn", "Wirichada Pongtavornpinyo", "Duangjai Sahassananda", "Kamolrat Silamut", "Kesinee Chotivanich", "Paul N Newton", "Punnee Pitisuttithum", "A. M Smithyman", "Nicholas J White", "Nicholas P. J Day"], "doi"=>"https://dx.doi.org/10.1371/journal.pmed.0020204.g002", "stats"=>{"downloads"=>1, "page_views"=>11, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Estimated_Total_Parasite_Biomass_as_a_Function_of_the_Parasite_Multiplication_Rate_Using_the_Model_Described_in_the_Text_/631507", "title"=>"Estimated Total Parasite Biomass as a Function of the Parasite Multiplication Rate, Using the Model Described in the Text", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-22 08:57:43"}
  • {"files"=>["https://ndownloader.figshare.com/files/961724"], "description"=>"<p>Plasma PfHRP2 concentrations (squares) in peripheral blood samples from 170 patients with uncomplicated malaria, 139 patients with severe malaria who survived, and 28 patients who died. For comparison the calculated circulating parasite biomass is also displayed (circles); this was calculated from the parasitaemia (per 1,000 red blood cells) in a peripheral blood sample and the estimated total red blood cell mass (see text for formulas).</p>", "links"=>[], "tags"=>["parasite", "biomass", "plasma", "pfhrp2"], "article_id"=>631700, "categories"=>["Infectious Diseases"], "users"=>["Arjen M Dondorp", "Varunee Desakorn", "Wirichada Pongtavornpinyo", "Duangjai Sahassananda", "Kamolrat Silamut", "Kesinee Chotivanich", "Paul N Newton", "Punnee Pitisuttithum", "A. M Smithyman", "Nicholas J White", "Nicholas P. J Day"], "doi"=>"https://dx.doi.org/10.1371/journal.pmed.0020204.g004", "stats"=>{"downloads"=>1, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Total_Log_10_Parasite_Biomass_Estimated_from_Plasma_PfHRP2_Concentrations_/631700", "title"=>"Total (Log<sub>10</sub>) Parasite Biomass Estimated from Plasma PfHRP2 Concentrations", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-22 08:59:02"}
  • {"files"=>["https://ndownloader.figshare.com/files/961643"], "description"=>"<p>Total (Log<sub>10</sub>) Parasite Biomass Estimated from Plasma PfHRP2 Concentrations in a Peripheral Blood Sample in 337 Patients with Falciparum Malaria</p>", "links"=>[], "tags"=>["parasite", "biomass", "plasma", "pfhrp2", "concentrations", "peripheral", "337", "patients", "falciparum"], "article_id"=>631622, "categories"=>["Infectious Diseases"], "users"=>["Arjen M Dondorp", "Varunee Desakorn", "Wirichada Pongtavornpinyo", "Duangjai Sahassananda", "Kamolrat Silamut", "Kesinee Chotivanich", "Paul N Newton", "Punnee Pitisuttithum", "A. M Smithyman", "Nicholas J White", "Nicholas P. J Day"], "doi"=>"https://dx.doi.org/10.1371/journal.pmed.0020204.g003", "stats"=>{"downloads"=>1, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Total_Log_10_Parasite_Biomass_Estimated_from_Plasma_PfHRP2_Concentrations_in_a_Peripheral_Blood_Sample_in_337_Patients_with_Falciparum_Malaria_/631622", "title"=>"Total (Log<sub>10</sub>) Parasite Biomass Estimated from Plasma PfHRP2 Concentrations in a Peripheral Blood Sample in 337 Patients with Falciparum Malaria", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-22 08:58:32"}

PMC Usage Stats | Further Information

  • {"month"=>"1", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"10", "year"=>"2010", "pdf"=>"5", "unique-ip"=>"12", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"2", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"5", "unique-ip"=>"8", "pdf"=>"3", "year"=>"2010", "figure"=>"1", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"3", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"8", "year"=>"2010", "pdf"=>"4", "unique-ip"=>"10", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"4", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"9", "unique-ip"=>"9", "pdf"=>"3", "year"=>"2010", "figure"=>"1", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"5", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"13", "year"=>"2010", "pdf"=>"9", "unique-ip"=>"12", "figure"=>"1", "scanned-summary"=>"0", "supp-data"=>"2"}
  • {"scanned-page-browse"=>"0", "month"=>"6", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"12", "unique-ip"=>"11", "pdf"=>"9", "year"=>"2010", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"7", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"4", "year"=>"2010", "pdf"=>"2", "unique-ip"=>"5", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"8", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"5", "unique-ip"=>"4", "pdf"=>"4", "year"=>"2010", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"9", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"8", "year"=>"2010", "pdf"=>"7", "unique-ip"=>"10", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"10", "cited-by"=>"0", "abstract"=>"4", "full-text"=>"7", "unique-ip"=>"12", "pdf"=>"4", "year"=>"2010", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"11", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"7", "year"=>"2010", "pdf"=>"1", "unique-ip"=>"7", "figure"=>"1", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"12", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"10", "unique-ip"=>"9", "pdf"=>"6", "year"=>"2010", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"1", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"9", "year"=>"2011", "pdf"=>"4", "unique-ip"=>"9", "figure"=>"2", "scanned-summary"=>"0", "supp-data"=>"1"}
  • {"scanned-page-browse"=>"0", "month"=>"2", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"6", "unique-ip"=>"9", "pdf"=>"5", "year"=>"2011", "figure"=>"2", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"3", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"2", "full-text"=>"12", "year"=>"2011", "pdf"=>"8", "unique-ip"=>"13", "figure"=>"4", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"4", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"2", "unique-ip"=>"6", "pdf"=>"4", "year"=>"2011", "figure"=>"2", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"5", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"2", "full-text"=>"6", "year"=>"2011", "pdf"=>"1", "unique-ip"=>"8", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"6", "cited-by"=>"0", "abstract"=>"3", "full-text"=>"8", "unique-ip"=>"11", "pdf"=>"6", "year"=>"2011", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"7", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"10", "year"=>"2011", "pdf"=>"4", "unique-ip"=>"9", "figure"=>"3", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"8", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"8", "unique-ip"=>"9", "pdf"=>"5", "year"=>"2011", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"9", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"17", "year"=>"2011", "pdf"=>"6", "unique-ip"=>"12", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"10", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"7", "unique-ip"=>"6", "pdf"=>"5", "year"=>"2011", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"11", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"4", "year"=>"2011", "pdf"=>"2", "unique-ip"=>"3", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"12", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"5", "unique-ip"=>"5", "pdf"=>"4", "year"=>"2011", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"1", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"1", "unique-ip"=>"1", "pdf"=>"1", "year"=>"2012", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"2", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"7", "year"=>"2012", "pdf"=>"4", "unique-ip"=>"7", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"3", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"4", "unique-ip"=>"4", "pdf"=>"2", "year"=>"2012", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"4", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"4", "year"=>"2012", "pdf"=>"4", "unique-ip"=>"5", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"5", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"10", "unique-ip"=>"7", "pdf"=>"8", "year"=>"2012", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"9", "scanned-page-browse"=>"25", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"4", "year"=>"2005", "pdf"=>"2", "unique-ip"=>"5", "figure"=>"75", "scanned-summary"=>"39", "supp-data"=>"35"}
  • {"scanned-page-browse"=>"7", "month"=>"10", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"1", "unique-ip"=>"4", "pdf"=>"0", "year"=>"2005", "figure"=>"35", "scanned-summary"=>"23", "supp-data"=>"21"}
  • {"month"=>"11", "scanned-page-browse"=>"10", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"0", "year"=>"2005", "pdf"=>"2", "unique-ip"=>"0", "figure"=>"39", "scanned-summary"=>"27", "supp-data"=>"21"}
  • {"scanned-page-browse"=>"5", "month"=>"12", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"0", "unique-ip"=>"0", "pdf"=>"0", "year"=>"2005", "figure"=>"27", "scanned-summary"=>"22", "supp-data"=>"17"}
  • {"month"=>"1", "scanned-page-browse"=>"13", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"2", "year"=>"2006", "pdf"=>"1", "unique-ip"=>"5", "figure"=>"44", "scanned-summary"=>"23", "supp-data"=>"21"}
  • {"scanned-page-browse"=>"18", "month"=>"2", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"1", "unique-ip"=>"4", "pdf"=>"0", "year"=>"2006", "figure"=>"45", "scanned-summary"=>"22", "supp-data"=>"22"}
  • {"month"=>"3", "scanned-page-browse"=>"4", "cited-by"=>"1", "abstract"=>"0", "full-text"=>"0", "year"=>"2006", "pdf"=>"0", "unique-ip"=>"0", "figure"=>"42", "scanned-summary"=>"38", "supp-data"=>"32"}
  • {"scanned-page-browse"=>"10", "month"=>"4", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"0", "unique-ip"=>"1", "pdf"=>"1", "year"=>"2006", "figure"=>"52", "scanned-summary"=>"40", "supp-data"=>"33"}
  • {"month"=>"5", "scanned-page-browse"=>"8", "cited-by"=>"1", "abstract"=>"0", "full-text"=>"1", "year"=>"2006", "pdf"=>"4", "unique-ip"=>"2", "figure"=>"37", "scanned-summary"=>"22", "supp-data"=>"19"}
  • {"scanned-page-browse"=>"5", "month"=>"6", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"0", "unique-ip"=>"0", "pdf"=>"0", "year"=>"2006", "figure"=>"20", "scanned-summary"=>"15", "supp-data"=>"14"}
  • {"month"=>"7", "scanned-page-browse"=>"5", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"0", "year"=>"2006", "pdf"=>"0", "unique-ip"=>"0", "figure"=>"17", "scanned-summary"=>"12", "supp-data"=>"9"}
  • {"scanned-page-browse"=>"9", "month"=>"8", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"0", "unique-ip"=>"0", "pdf"=>"0", "year"=>"2006", "figure"=>"22", "scanned-summary"=>"13", "supp-data"=>"12"}
  • {"month"=>"9", "scanned-page-browse"=>"4", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"1", "year"=>"2006", "pdf"=>"0", "unique-ip"=>"0", "figure"=>"16", "scanned-summary"=>"11", "supp-data"=>"11"}
  • {"scanned-page-browse"=>"9", "month"=>"10", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"1", "unique-ip"=>"0", "pdf"=>"1", "year"=>"2006", "figure"=>"24", "scanned-summary"=>"13", "supp-data"=>"14"}
  • {"month"=>"11", "scanned-page-browse"=>"5", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"1", "year"=>"2006", "pdf"=>"2", "unique-ip"=>"4", "figure"=>"23", "scanned-summary"=>"10", "supp-data"=>"10"}
  • {"scanned-page-browse"=>"4", "month"=>"12", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"0", "unique-ip"=>"0", "pdf"=>"0", "year"=>"2006", "figure"=>"12", "scanned-summary"=>"8", "supp-data"=>"9"}
  • {"month"=>"1", "scanned-page-browse"=>"5", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"0", "year"=>"2007", "pdf"=>"4", "unique-ip"=>"0", "figure"=>"21", "scanned-summary"=>"12", "supp-data"=>"9"}
  • {"scanned-page-browse"=>"11", "month"=>"2", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"0", "unique-ip"=>"0", "pdf"=>"0", "year"=>"2007", "figure"=>"25", "scanned-summary"=>"14", "supp-data"=>"14"}
  • {"month"=>"3", "scanned-page-browse"=>"4", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"0", "year"=>"2007", "pdf"=>"0", "unique-ip"=>"0", "figure"=>"17", "scanned-summary"=>"13", "supp-data"=>"10"}
  • {"scanned-page-browse"=>"1", "month"=>"4", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"0", "unique-ip"=>"0", "pdf"=>"0", "year"=>"2007", "figure"=>"8", "scanned-summary"=>"7", "supp-data"=>"7"}
  • {"month"=>"5", "scanned-page-browse"=>"8", "cited-by"=>"1", "abstract"=>"0", "full-text"=>"0", "year"=>"2007", "pdf"=>"7", "unique-ip"=>"2", "figure"=>"40", "scanned-summary"=>"23", "supp-data"=>"16"}
  • {"scanned-page-browse"=>"1", "month"=>"6", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"0", "unique-ip"=>"0", "pdf"=>"1", "year"=>"2007", "figure"=>"5", "scanned-summary"=>"3", "supp-data"=>"3"}
  • {"month"=>"7", "scanned-page-browse"=>"9", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"0", "year"=>"2007", "pdf"=>"0", "unique-ip"=>"0", "figure"=>"21", "scanned-summary"=>"12", "supp-data"=>"12"}
  • {"scanned-page-browse"=>"7", "month"=>"8", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"2", "unique-ip"=>"0", "pdf"=>"0", "year"=>"2007", "figure"=>"27", "scanned-summary"=>"18", "supp-data"=>"18"}
  • {"month"=>"9", "scanned-page-browse"=>"3", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"0", "year"=>"2007", "pdf"=>"0", "unique-ip"=>"0", "figure"=>"16", "scanned-summary"=>"13", "supp-data"=>"14"}
  • {"scanned-page-browse"=>"6", "month"=>"10", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"0", "unique-ip"=>"0", "pdf"=>"0", "year"=>"2007", "figure"=>"16", "scanned-summary"=>"10", "supp-data"=>"10"}
  • {"month"=>"11", "scanned-page-browse"=>"6", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"1", "year"=>"2007", "pdf"=>"0", "unique-ip"=>"0", "figure"=>"16", "scanned-summary"=>"9", "supp-data"=>"11"}
  • {"scanned-page-browse"=>"5", "month"=>"12", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"0", "unique-ip"=>"0", "pdf"=>"0", "year"=>"2007", "figure"=>"10", "scanned-summary"=>"5", "supp-data"=>"6"}
  • {"month"=>"1", "scanned-page-browse"=>"5", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"0", "year"=>"2008", "pdf"=>"0", "unique-ip"=>"0", "figure"=>"15", "scanned-summary"=>"10", "supp-data"=>"9"}
  • {"scanned-page-browse"=>"13", "month"=>"2", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"0", "unique-ip"=>"0", "pdf"=>"0", "year"=>"2008", "figure"=>"32", "scanned-summary"=>"19", "supp-data"=>"18"}
  • {"month"=>"3", "scanned-page-browse"=>"3", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"0", "year"=>"2008", "pdf"=>"0", "unique-ip"=>"2", "figure"=>"13", "scanned-summary"=>"8", "supp-data"=>"7"}
  • {"scanned-page-browse"=>"10", "month"=>"4", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"0", "unique-ip"=>"0", "pdf"=>"1", "year"=>"2008", "figure"=>"31", "scanned-summary"=>"19", "supp-data"=>"17"}
  • {"month"=>"5", "scanned-page-browse"=>"6", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"0", "year"=>"2008", "pdf"=>"0", "unique-ip"=>"0", "figure"=>"17", "scanned-summary"=>"11", "supp-data"=>"10"}
  • {"scanned-page-browse"=>"2", "month"=>"6", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"0", "unique-ip"=>"4", "pdf"=>"1", "year"=>"2008", "figure"=>"14", "scanned-summary"=>"7", "supp-data"=>"6"}
  • {"month"=>"7", "scanned-page-browse"=>"4", "cited-by"=>"1", "abstract"=>"0", "full-text"=>"0", "year"=>"2008", "pdf"=>"0", "unique-ip"=>"0", "figure"=>"19", "scanned-summary"=>"15", "supp-data"=>"12"}
  • {"scanned-page-browse"=>"8", "month"=>"8", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"0", "unique-ip"=>"0", "pdf"=>"0", "year"=>"2008", "figure"=>"21", "scanned-summary"=>"13", "supp-data"=>"13"}
  • {"month"=>"9", "scanned-page-browse"=>"3", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"3", "year"=>"2008", "pdf"=>"0", "unique-ip"=>"0", "figure"=>"12", "scanned-summary"=>"6", "supp-data"=>"7"}
  • {"scanned-page-browse"=>"0", "month"=>"10", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"12", "unique-ip"=>"14", "pdf"=>"6", "year"=>"2008", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"11", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"6", "year"=>"2008", "pdf"=>"4", "unique-ip"=>"5", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"12", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"3", "unique-ip"=>"4", "pdf"=>"2", "year"=>"2008", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"1", "scanned-page-browse"=>"0", "cited-by"=>"1", "abstract"=>"1", "full-text"=>"5", "year"=>"2009", "pdf"=>"6", "unique-ip"=>"8", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"2", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"6", "unique-ip"=>"7", "pdf"=>"3", "year"=>"2009", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"2"}
  • {"month"=>"3", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"3", "full-text"=>"20", "year"=>"2009", "pdf"=>"13", "unique-ip"=>"17", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"4", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"15", "unique-ip"=>"16", "pdf"=>"12", "year"=>"2009", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"5", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"22", "year"=>"2009", "pdf"=>"7", "unique-ip"=>"19", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"1"}
  • {"scanned-page-browse"=>"0", "month"=>"6", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"15", "unique-ip"=>"16", "pdf"=>"7", "year"=>"2009", "figure"=>"1", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"7", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"2", "full-text"=>"5", "year"=>"2009", "pdf"=>"1", "unique-ip"=>"7", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"8", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"12", "unique-ip"=>"12", "pdf"=>"4", "year"=>"2009", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"9", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"6", "year"=>"2009", "pdf"=>"3", "unique-ip"=>"6", "figure"=>"1", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"10", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"2", "unique-ip"=>"2", "pdf"=>"1", "year"=>"2009", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"11", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"11", "year"=>"2009", "pdf"=>"6", "unique-ip"=>"14", "figure"=>"5", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"12", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"12", "unique-ip"=>"13", "pdf"=>"3", "year"=>"2009", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"6", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"3", "year"=>"2012", "pdf"=>"0", "unique-ip"=>"3", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"unique-ip"=>"13", "full-text"=>"17", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"7"}
  • {"unique-ip"=>"15", "full-text"=>"23", "pdf"=>"10", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"8"}
  • {"unique-ip"=>"7", "full-text"=>"8", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"9"}
  • {"unique-ip"=>"14", "full-text"=>"8", "pdf"=>"4", "abstract"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"10"}
  • {"unique-ip"=>"3", "full-text"=>"1", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"12"}
  • {"unique-ip"=>"13", "full-text"=>"16", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"1"}
  • {"unique-ip"=>"17", "full-text"=>"23", "pdf"=>"11", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2013", "month"=>"2"}
  • {"unique-ip"=>"12", "full-text"=>"13", "pdf"=>"7", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"3"}
  • {"unique-ip"=>"8", "full-text"=>"9", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"4"}
  • {"unique-ip"=>"8", "full-text"=>"8", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"11"}
  • {"unique-ip"=>"7", "full-text"=>"6", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"5"}
  • {"unique-ip"=>"7", "full-text"=>"3", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"6"}
  • {"unique-ip"=>"5", "full-text"=>"6", "pdf"=>"2", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"7"}
  • {"unique-ip"=>"8", "full-text"=>"10", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2013", "month"=>"8"}
  • {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"9"}
  • {"unique-ip"=>"9", "full-text"=>"9", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"10"}
  • {"unique-ip"=>"7", "full-text"=>"7", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"11"}
  • {"unique-ip"=>"9", "full-text"=>"6", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"12"}
  • {"unique-ip"=>"19", "full-text"=>"19", "pdf"=>"10", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"1"}
  • {"unique-ip"=>"8", "full-text"=>"10", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"2"}
  • {"unique-ip"=>"5", "full-text"=>"6", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"3"}
  • {"unique-ip"=>"16", "full-text"=>"15", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"5"}
  • {"unique-ip"=>"7", "full-text"=>"7", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"6"}
  • {"unique-ip"=>"10", "full-text"=>"10", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"4"}
  • {"unique-ip"=>"15", "full-text"=>"13", "pdf"=>"10", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"7"}
  • {"unique-ip"=>"13", "full-text"=>"12", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"8"}
  • {"unique-ip"=>"7", "full-text"=>"9", "pdf"=>"2", "abstract"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"9"}
  • {"unique-ip"=>"23", "full-text"=>"15", "pdf"=>"8", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"6", "cited-by"=>"0", "year"=>"2014", "month"=>"10"}
  • {"unique-ip"=>"15", "full-text"=>"16", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"11"}
  • {"unique-ip"=>"10", "full-text"=>"11", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"12"}
  • {"unique-ip"=>"12", "full-text"=>"13", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"1"}
  • {"unique-ip"=>"9", "full-text"=>"9", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"2"}
  • {"unique-ip"=>"9", "full-text"=>"11", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"3"}
  • {"unique-ip"=>"11", "full-text"=>"11", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2015", "month"=>"4"}
  • {"unique-ip"=>"14", "full-text"=>"16", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"5"}
  • {"unique-ip"=>"19", "full-text"=>"23", "pdf"=>"12", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2015", "month"=>"6"}
  • {"unique-ip"=>"21", "full-text"=>"23", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2015", "month"=>"7"}
  • {"unique-ip"=>"14", "full-text"=>"12", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"8"}
  • {"unique-ip"=>"20", "full-text"=>"17", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"9"}
  • {"unique-ip"=>"22", "full-text"=>"18", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"10"}
  • {"unique-ip"=>"16", "full-text"=>"13", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"5", "year"=>"2015", "month"=>"11"}
  • {"unique-ip"=>"11", "full-text"=>"12", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"12"}
  • {"unique-ip"=>"11", "full-text"=>"10", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"1"}
  • {"unique-ip"=>"12", "full-text"=>"13", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"2"}
  • {"unique-ip"=>"13", "full-text"=>"13", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"3"}
  • {"unique-ip"=>"7", "full-text"=>"8", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"4"}
  • {"unique-ip"=>"11", "full-text"=>"10", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"5"}
  • {"unique-ip"=>"13", "full-text"=>"14", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"6"}
  • {"unique-ip"=>"15", "full-text"=>"15", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"7"}
  • {"unique-ip"=>"7", "full-text"=>"9", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"8"}
  • {"unique-ip"=>"11", "full-text"=>"16", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"9"}
  • {"unique-ip"=>"14", "full-text"=>"14", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"10"}
  • {"unique-ip"=>"8", "full-text"=>"10", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"11"}
  • {"unique-ip"=>"9", "full-text"=>"11", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"12"}
  • {"unique-ip"=>"16", "full-text"=>"15", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2017", "month"=>"1"}
  • {"unique-ip"=>"10", "full-text"=>"10", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2017", "month"=>"2"}
  • {"unique-ip"=>"11", "full-text"=>"13", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"3"}
  • {"unique-ip"=>"9", "full-text"=>"10", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"4"}
  • {"unique-ip"=>"16", "full-text"=>"18", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"5"}
  • {"unique-ip"=>"12", "full-text"=>"13", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"6"}
  • {"unique-ip"=>"10", "full-text"=>"14", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2017", "month"=>"7"}
  • {"unique-ip"=>"10", "full-text"=>"10", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2017", "month"=>"8"}
  • {"unique-ip"=>"11", "full-text"=>"11", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"9"}
  • {"unique-ip"=>"11", "full-text"=>"10", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"10"}
  • {"unique-ip"=>"19", "full-text"=>"21", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"3", "year"=>"2017", "month"=>"11"}
  • {"unique-ip"=>"13", "full-text"=>"12", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2017", "month"=>"12"}
  • {"unique-ip"=>"16", "full-text"=>"17", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"1"}
  • {"unique-ip"=>"1", "full-text"=>"1", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"2"}
  • {"unique-ip"=>"10", "full-text"=>"8", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"3"}
  • {"unique-ip"=>"13", "full-text"=>"11", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2019", "month"=>"1"}
  • {"unique-ip"=>"13", "full-text"=>"16", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2018", "month"=>"4"}
  • {"unique-ip"=>"9", "full-text"=>"8", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2018", "month"=>"6"}
  • {"unique-ip"=>"13", "full-text"=>"14", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2018", "month"=>"5"}
  • {"unique-ip"=>"13", "full-text"=>"13", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"1", "year"=>"2018", "month"=>"7"}
  • {"unique-ip"=>"10", "full-text"=>"8", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"8"}
  • {"unique-ip"=>"12", "full-text"=>"10", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2018", "month"=>"9"}
  • {"unique-ip"=>"13", "full-text"=>"15", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2018", "month"=>"10"}
  • {"unique-ip"=>"21", "full-text"=>"20", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"2", "cited-by"=>"1", "year"=>"2018", "month"=>"11"}
  • {"unique-ip"=>"7", "full-text"=>"7", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2018", "month"=>"12"}
  • {"unique-ip"=>"12", "full-text"=>"18", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2019", "month"=>"2"}
  • {"unique-ip"=>"18", "full-text"=>"18", "pdf"=>"6", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2019", "month"=>"3"}
  • {"unique-ip"=>"10", "full-text"=>"10", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2019", "month"=>"4"}
  • {"unique-ip"=>"18", "full-text"=>"17", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2019", "month"=>"5"}
  • {"unique-ip"=>"8", "full-text"=>"8", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2019", "month"=>"8"}
  • {"unique-ip"=>"34", "full-text"=>"37", "pdf"=>"9", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"2", "cited-by"=>"2", "year"=>"2019", "month"=>"9"}
  • {"unique-ip"=>"26", "full-text"=>"27", "pdf"=>"6", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2019", "month"=>"10"}

Relative Metric

{"start_date"=>"2005-01-01T00:00:00Z", "end_date"=>"2005-12-31T00:00:00Z", "subject_areas"=>[{"subject_area"=>"/Biology and life sciences/Anatomy", "average_usage"=>[318, 750, 951, 1079, 1198, 1314, 1380, 1480, 1566, 1641, 1744, 1781, 1850, 1951, 2037, 2090, 2146, 2186, 2229, 2270, 2315, 2348, 2385, 2453, 2568, 2618, 2678, 2722, 2769, 2797, 2826, 2843, 2872, 2886, 2920, 2964, 3046, 3134, 3193, 3244, 3302, 3342, 3372, 3419, 3464, 3499, 3546, 3591, 3634, 3673, 3713, 3746, 3783, 3828, 3850, 3880, 3906, 3935, 3957, 3991, 4020, 4050, 4085, 4122, 4141, 4158, 4182, 4205, 4230, 4258, 4300, 4328, 4342, 4357, 4379, 4397, 4416, 4474, 4531, 4551, 4567, 4581, 4608, 4627, 4686, 4715, 4864, 4965, 4991, 5040, 5072, 5105, 5133, 5170, 5238, 5276, 5313, 5379, 5426, 5467, 5516, 5565, 5601, 5655, 5722, 5770, 5834, 5907, 5951]}, {"subject_area"=>"/Biology and life sciences/Anatomy and physiology", "average_usage"=>[350, 850, 1120, 1274, 1434, 1549, 1623, 1696, 1756, 1859, 1931, 2006, 2053, 2164, 2291, 2319, 2351, 2398, 2481, 2546, 2593, 2630, 2666, 2710, 2762, 2782, 2810, 2837, 2864, 2891, 2958, 2979, 3000, 3103, 3170, 3244, 3283, 3314, 3346, 3377, 3418, 3484, 3533, 3607, 3636, 3660, 3681, 3708, 3747, 3784, 3810, 3862, 3889, 3945, 4005, 4071, 4108, 4127, 4189, 4222, 4243, 4275, 4294, 4352, 4415, 4440, 4463, 4484, 4508, 4538, 4574, 4627, 4665, 4709, 4752, 4783, 4810, 4857, 4897, 4943, 5018, 5076, 5137, 5186, 5228, 5274, 5312, 5351, 5390, 5436, 5475, 5526, 5577, 5689, 5802]}, {"subject_area"=>"/Biology and life sciences/Cell biology", "average_usage"=>[336, 898, 1202, 1349, 1463, 1567, 1688, 1812, 1925, 2038, 2149, 2233, 2308, 2394, 2437, 2517, 2573, 2610, 2670, 2730, 2776, 2795, 2872, 2909, 2987, 3049, 3085, 3132, 3194, 3233, 3289, 3354, 3385, 3419, 3444, 3468, 3499, 3534, 3566, 3605, 3659, 3709, 3764, 3798, 3844, 3905, 3960, 4025, 4072, 4120, 4160, 4192, 4236, 4282, 4311, 4367, 4395, 4431, 4477, 4520, 4573, 4637, 4700, 4733, 4769, 4811, 4848, 4883, 4918, 4954, 4994, 5052, 5092, 5121, 5160, 5190, 5229, 5301, 5375, 5432, 5482, 5525, 5572, 5610, 5653, 5696, 5735, 5774, 5810, 5846, 5891, 5940, 5978, 6062, 6149, 6214, 6264, 6302, 6348, 6434, 6518, 6653, 6732, 6851, 6900, 6977, 7047, 7090, 7157]}, {"subject_area"=>"/Biology and life sciences/Organisms", "average_usage"=>[379, 969, 1232, 1403, 1550, 1693, 1815, 1916, 2038, 2126, 2221, 2318, 2385, 2460, 2560, 2650, 2722, 2814, 2896, 2950, 3045, 3106, 3151, 3206, 3252, 3326, 3380, 3439, 3459, 3485, 3538, 3656, 3724, 3768, 3806, 3849, 3906, 3996, 4069, 4141, 4205, 4283, 4352, 4436, 4521, 4569, 4605, 4664, 4724, 4783, 4858, 4913, 4965, 5013, 5051, 5083, 5142, 5235, 5270, 5293, 5325, 5366, 5421, 5467, 5505, 5550, 5635, 5676, 5721, 5742, 5780, 5837, 5883, 5915, 5944, 6006, 6045, 6080, 6139, 6180, 6224, 6287, 6337, 6396, 6452, 6490, 6544, 6613, 6662, 6727, 6810, 6900, 6990, 7053, 7090, 7146, 7253, 7305, 7365, 7403, 7445, 7512, 7548, 7597, 7675, 7749, 7812, 7888, 8009]}, {"subject_area"=>"/Biology and life sciences/Parasitology", "average_usage"=>[400, 848, 1071, 1268, 1412, 1541, 1605, 1657, 1723, 1773, 1876, 2041, 2109, 2205, 2291, 2360, 2422, 2490, 2553, 2621, 2668, 2712, 2795, 2855, 2882, 2896, 2916, 2950, 2995, 3012, 3027, 3061, 3086, 3113, 3136, 3171, 3202, 3230, 3271, 3310, 3359, 3388, 3421, 3460, 3507, 3530, 3547, 3556, 3580, 3599, 3620, 3635, 3678, 3727, 3771, 3826, 3898, 3973, 4075, 4123, 4169, 4233, 4290, 4343, 4395, 4438, 4484, 4530, 4584, 4631, 4679, 4737, 4793, 4870, 4931, 4974, 5030, 5086, 5152, 5202, 5296, 5401, 5479, 5562, 5698, 5760, 5833, 5902, 5940, 6056, 6154, 6252, 6356, 6497, 6587, 6648, 6741, 6842, 6889, 6911, 6944, 6970, 7003, 7063, 7118, 7157, 7184, 7245, 7290, 7369]}, {"subject_area"=>"/Medicine and health sciences", "average_usage"=>[332, 832, 1061, 1198, 1288, 1420, 1545, 1670, 1785, 1867, 1947, 2027, 2093, 2161, 2245, 2305, 2356, 2424, 2497, 2566, 2606, 2658, 2705, 2747, 2800, 2839, 2894, 2934, 2991, 3034, 3061, 3096, 3143, 3189, 3237, 3282, 3313, 3379, 3408, 3472, 3517, 3553, 3603, 3632, 3666, 3693, 3724, 3749, 3796, 3824, 3877, 3904, 3961, 4025, 4073, 4141, 4175, 4212, 4222, 4284, 4335, 4367, 4390, 4422, 4462, 4479, 4496, 4540, 4603, 4661, 4687, 4716, 4750, 4800, 4850, 4873, 4921, 4993, 5033, 5129, 5183, 5228, 5268, 5296, 5323, 5378, 5411, 5474, 5537, 5594, 5649, 5682, 5777, 5823, 5856, 5927, 6016, 6062, 6102, 6147, 6214, 6253, 6428, 6501, 6543, 6588, 6622, 6649, 6728]}, {"subject_area"=>"/Medicine and health sciences/Anatomy", "average_usage"=>[314, 722, 939, 1057, 1208, 1333, 1385, 1494, 1572, 1649, 1752, 1825, 1960, 2070, 2172, 2258, 2332, 2414, 2477, 2516, 2561, 2600, 2639, 2704, 2738, 2755, 2788, 2807, 2843, 2859, 2958, 2970, 2986, 3045, 3085, 3111, 3146, 3189, 3237, 3279, 3316, 3357, 3428, 3477, 3500, 3532, 3593, 3638, 3715, 3749, 3776, 3808, 3845, 3883, 3932, 3950, 4009, 4043, 4069, 4094, 4146, 4189, 4197, 4210, 4223, 4240, 4248, 4254, 4277, 4295, 4346, 4375, 4404, 4433, 4447, 4468, 4509, 4551, 4629, 4697, 4730, 4752, 4769, 4802, 4816, 4844, 4950, 4980, 5004, 5088, 5107, 5123, 5157, 5217, 5262, 5439, 5511, 5584, 5666, 5683, 5703, 5751, 5798, 5838, 5858, 5876, 5913, 5960, 6009]}, {"subject_area"=>"/Medicine and health sciences/Anatomy and physiology", "average_usage"=>[350, 850, 1104, 1261, 1420, 1515, 1598, 1675, 1720, 1823, 1923, 1989, 2045, 2109, 2234, 2265, 2300, 2343, 2438, 2497, 2551, 2604, 2652, 2710, 2755, 2782, 2810, 2837, 2864, 2891, 2958, 2979, 3000, 3103, 3170, 3244, 3283, 3314, 3346, 3377, 3418, 3484, 3533, 3607, 3636, 3660, 3681, 3708, 3747, 3784, 3810, 3862, 3889, 3945, 4005, 4071, 4108, 4127, 4189, 4222, 4243, 4275, 4294, 4352, 4415, 4440, 4463, 4484, 4508, 4538, 4574, 4627, 4665, 4709, 4752, 4783, 4810, 4857, 4897, 4943, 5018, 5076, 5137, 5186, 5228, 5274, 5312, 5351, 5390, 5436, 5475, 5526, 5577, 5689, 5802]}, {"subject_area"=>"/Medicine and health sciences/Parasitic diseases", "average_usage"=>[321, 795, 967, 1105, 1250, 1369, 1460, 1558, 1646, 1769, 1897, 2037, 2157, 2232, 2316, 2383, 2446, 2521, 2607, 2671, 2727, 2777, 2812, 2894, 2955, 3069, 3135, 3186, 3269, 3338, 3429, 3494, 3562, 3635, 3694, 3757, 3838, 3953, 4043, 4150, 4268, 4373, 4428, 4487, 4544, 4602, 4655, 4704, 4765, 4820, 4890, 4956, 5017, 5077, 5133, 5179, 5247, 5310, 5389, 5431, 5479, 5521, 5579, 5619, 5676, 5731, 5768, 5810, 5845, 5895, 5921, 5953, 5968, 6000, 6037, 6066, 6107, 6139, 6177, 6236, 6280, 6310, 6338, 6373, 6413, 6444, 6478, 6518, 6548, 6582, 6621, 6639, 6669, 6703, 6726, 6755, 6784, 6809, 6841, 6876, 6905, 6931, 6958, 6994, 7035, 7071, 7100, 7147, 7180, 7230]}, {"subject_area"=>"/Medicine and health sciences/Tropical diseases", "average_usage"=>[272, 861, 1050, 1145, 1287, 1393, 1476, 1567, 1670, 1756, 1851, 1954, 2006, 2069, 2156, 2238, 2345, 2503, 2585, 2633, 2691, 2732, 2769, 2814, 2846, 2869, 2888, 2919, 2952, 2983, 3035, 3071, 3108, 3146, 3180, 3206, 3247, 3290, 3328, 3390, 3461, 3546, 3664, 3740, 3787, 3852, 3913, 4038, 4093, 4148, 4224, 4273, 4315, 4379, 4467, 4548, 4582, 4621, 4666, 4721, 4783, 4831, 4885, 4930, 4974, 5020, 5070, 5118, 5156, 5186, 5220, 5250, 5294, 5343, 5385, 5426, 5461, 5495, 5549, 5600, 5649, 5703, 5757, 5795, 5851, 5894, 5929, 5973, 6029, 6052, 6084, 6110, 6130, 6181, 6205, 6230, 6265, 6286, 6322, 6345, 6373, 6424, 6471, 6504, 6542, 6577, 6608, 6650, 6702]}]}
Loading … Spinner
There are currently no alerts