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• {"link"=>{"url"=>"http://www.citeulike.org/user/nickmechanicalcheatham/article/10176876"}, "post_time"=>"2013-02-08 06:55:08", "tag"=>"no-tag", "linkout"=>{"type"=>"DOI", "url"=>"http://dx.doi.org/10.1371/journal.pmed.0020359"}, "username"=>"nickmechanicalcheatham", "article_id"=>"10176876"}
• {"link"=>{"url"=>"http://www.citeulike.org/user/hmedal/article/10176876"}, "post_time"=>"2011-12-28 22:19:56", "tag"=>"epidemic-preparedness", "linkout"=>{"type"=>"DOI", "url"=>"http://dx.doi.org/10.1371/journal.pmed.0020359"}, "username"=>"hmedal", "article_id"=>"10176876"}

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{"title"=>"A systematic analytic approach to pandemic influenza preparedness planning", "type"=>"generic", "authors"=>[{"first_name"=>"Daniel J.", "last_name"=>"Barnett", "scopus_author_id"=>"8339795200"}, {"first_name"=>"Ran D.", "last_name"=>"Balicer", "scopus_author_id"=>"6603332644"}, {"first_name"=>"Daniel R.", "last_name"=>"Lucey", "scopus_author_id"=>"56364451100"}, {"first_name"=>"George S.", "last_name"=>"Everly", "scopus_author_id"=>"35606472200"}, {"first_name"=>"Saad B.", "last_name"=>"Omer", "scopus_author_id"=>"7004179861"}, {"first_name"=>"Mark C.", "last_name"=>"Steinhoff", "scopus_author_id"=>"7101666789"}, {"first_name"=>"Itamar", "last_name"=>"Grotto", "scopus_author_id"=>"7004310151"}], "year"=>2005, "source"=>"PLoS Medicine", "identifiers"=>{"issn"=>"15491277", "scopus"=>"2-s2.0-29644446450", "pui"=>"43020981", "doi"=>"10.1371/journal.pmed.0020359", "isbn"=>"1549-1676 (Electronic)\\r1549-1277 (Linking)", "sgr"=>"29644446450", "pmid"=>"16255619"}, "id"=>"bb92511e-d2db-3bf4-8bbf-3b93ac7e49a2", "abstract"=>"The World Health Organization warns that a flu pandemic is inevitable, and possibly imminent. Barnett and colleagues discuss a tool called the Haddon Matrix that could help in pandemic influenza planning.", "link"=>"http://www.mendeley.com/research/systematic-analytic-approach-pandemic-influenza-preparedness-planning", "reader_count"=>48, "reader_count_by_academic_status"=>{"Unspecified"=>2, "Professor > Associate Professor"=>7, "Librarian"=>1, "Student > Doctoral Student"=>1, "Researcher"=>11, "Student > Ph. D. Student"=>8, "Student > Postgraduate"=>1, "Student > Master"=>4, "Other"=>3, "Student > Bachelor"=>6, "Lecturer > Senior Lecturer"=>1, "Professor"=>3}, "reader_count_by_user_role"=>{"Unspecified"=>2, "Professor > Associate Professor"=>7, "Librarian"=>1, "Student > Doctoral Student"=>1, "Researcher"=>11, "Student > Ph. D. Student"=>8, "Student > Postgraduate"=>1, "Student > Master"=>4, "Other"=>3, "Student > Bachelor"=>6, "Lecturer > Senior Lecturer"=>1, "Professor"=>3}, "reader_count_by_subject_area"=>{"Unspecified"=>4, "Agricultural and Biological Sciences"=>11, "Arts and Humanities"=>1, "Business, Management and Accounting"=>1, "Economics, Econometrics and Finance"=>1, "Engineering"=>1, "Environmental Science"=>1, "Nursing and Health Professions"=>2, "Medicine and Dentistry"=>17, "Physics and Astronomy"=>1, "Psychology"=>1, "Social Sciences"=>6, "Immunology and Microbiology"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>17}, "Social Sciences"=>{"Social Sciences"=>6}, "Physics and Astronomy"=>{"Physics and Astronomy"=>1}, "Psychology"=>{"Psychology"=>1}, "Unspecified"=>{"Unspecified"=>4}, "Environmental Science"=>{"Environmental Science"=>1}, "Arts and Humanities"=>{"Arts and Humanities"=>1}, "Engineering"=>{"Engineering"=>1}, "Economics, Econometrics and Finance"=>{"Economics, Econometrics and Finance"=>1}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>11}, "Business, Management and Accounting"=>{"Business, Management and Accounting"=>1}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>2}}, "reader_count_by_country"=>{"Republic of Singapore"=>1, "United States"=>1}, "group_count"=>5}

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• http://doi.org/10.3280/PM2015-021008
• http://doi.org/10.2217/17460794.2.3.231
• http://doi.org/10.5694/j.1326-5377.2007.tb00937.x
• http://doi.org/10.1080/10810730.2013.840696
• http://doi.org/10.1186/s12910-015-0025-9
• http://doi.org/10.1371/journal.pone.0000020
• http://doi.org/10.1016/j.socscimed.2008.06.020
• http://doi.org/10.1007/s40572-016-0102-3
• http://doi.org/10.1108/LHS-04-2012-0010
• http://doi.org/10.1186/1471-2458-9-161
• http://doi.org/10.1001/dmp-v4n2-hcn10003
• http://doi.org/10.1136/injuryprev-2015-041568
• http://doi.org/10.3201/eid1406.070839
• http://doi.org/10.1016/j.jiph.2009.03.002
• http://doi.org/10.1016/j.amepre.2011.05.026
• http://doi.org/10.1111/tid.13373
• http://doi.org/10.1371/journal.pone.0002269
• http://doi.org/10.5367/oa.2012.0091
• http://doi.org/10.1017/dmp.2020.30
• http://doi.org/10.1016/j.virol.2006.06.024
• http://doi.org/10.1016/j.vaccine.2009.07.107

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• {"url"=>"http%3A%2F%2Fjournals.plos.org%2Fplosmedicine%2Farticle%3Fid%3D10.1371%252Fjournal.pmed.0020359", "share_count"=>0, "like_count"=>0, "comment_count"=>0, "click_count"=>0, "total_count"=>0}

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• {"type"=>"COMMENT", "annotationUri"=>"info:doi/10.1371/annotation/26f63cd2-24e9-4d8e-9f23-edf522a422a1", "title"=>"Useful Web and Book Resources", "body"=>"Author: Bob Kahn\nPosition: Co-ordinator\nInstitution: Avian Flu Action (UK)\nE-mail: rs_kahn@hotmail.com\nSubmitted Date: November 16, 2005\nPublished Date: November 16, 2005\nThis comment was originally posted as a “Reader Response” on the publication date indicated above. All Reader Responses are now available as comments.\n\nThis article with its focus on the Haddon matrix is very helpful. To keep up to date, those involved in pandemic influenza planning may find the following resources helpful:\n1. The weekly update from the Centre for Infectious Disease Research & Policy at the University of Minnesota, especially the articles from its director, Michael T. Osterholm, on the web at: http://www.cidrap.umn.edu/\n\n2.An important international conference in London on 19-20 January at St Bartholomew's Hospital, London, UK on \"Bird Flu: The first pandemic of the 21st Century: A central role for antivirals\" chaired by Profs. John Oxford (London), Albert Osterhaus (Rotterdam) and Fred Hayden (Virginia). Other speakers include J. Taubenberger (USA), D. Fleming (UK), C. Hannoun (France), N. Ferguson (UK), G. Laver (Australia) and D. Reddy (Switzerland). Full information on the web at: http://www.retroscreen.com/conference/programme.php\n\n3. A helpful analysis of Australia's approach to avian influenza planning at the website of the risk consultants, Peter M. Sandman, Phd and Jody Lanard, MD, \"Superb Flu Pandemic Risk Communication: A Role Model from Australia\" on the web at: http://www.psandman.com/col/abbott.htm\n\n4. An educational website from a British group, Avian Flu Action, of which I am the Co-ordinator, sets out a number of resources, on the web at: http://www.avianfluaction.org\n\nBooks of interest include:\n\n1. John M. Barry, \"The Great Influenza: The Epic Story of The Deadliest Plauge in History,\" (Penguin, 2004)\n\n2. Cass R. Sunstein, \"Laws of Fear: Beyond the Precautionary Principles\" (Cambridge University Press, 2005)\n\n3. Laurie Garrett, \"Betrayal of Trust: The Collapse of Global Public Health\" (Hyperion, 2000)\n\n4. Mike Davis, \"The Monster at Our Door: The Global Threat of Avian Flu\" (The New Press, 2005).\n\nThe current state of epidemic and pandemic alert in the view of the World Health Organization is presently 3 which is \"No or very limited human-to-human transmission\" as of 15 November 2005. For updates see the WHO website at: http://who.int/csr/disease/avian_influenza/phase/en/index.html", "isRemoved"=>false, "created"=>"2009-03-30T23:48:31Z", "lastModified"=>"2009-03-30T23:48:31Z", "creator"=>{"userId"=>"172479"}, "highlightedText"=>"", "competingInterestStatement"=>{"creatorWasPrompted"=>true, "hasCompetingInterests"=>true, "body"=>"Involved (rather than a competing interest), but I am Co-ordinator of a small British educational group: Avian Flu Action"}, "parentArticle"=>{"doi"=>"info:doi/10.1371/journal.pmed.0020359", "state"=>"published", "journals"=>{"PLoSMedicine"=>{"journalKey"=>"PLoSMedicine", "eIssn"=>"1549-1676", "title"=>"PLOS Medicine"}}}, "replyTreeSize"=>0, "mostRecentActivity"=>"2009-03-30T23:48:31Z", "replies"=>[]}
• {"type"=>"COMMENT", "annotationUri"=>"info:doi/10.1371/annotation/cebffb9e-bc43-4987-8743-8aa5d3b56c36", "title"=>"Preventing mass deaths", "body"=>"Author: Charles Johnson\nPosition: Software\nInstitution: Valverde Computing\nE-mail: CharlesOne@Yahoo.Com\nSubmitted Date: June 05, 2006\nPublished Date: June 8, 2006\nThis comment was originally posted as a “Reader Response” on the publication date indicated above. All Reader Responses are now available as comments.\n\nTo a casual observer, there appears to be a billion young people at risk of death. As several experts have stated the problem, those with strong immune systems are most at risk.\n\nPublic Policy and Ethics Questions:\n\n1. If most of those most at risk are between 20-40, representing the inversion of the usual flu deaths of the young and the old (or pregnant women with a death rate as high as 50%) then, rather than simply letting vast numbers of these populations die when the disease is contracted with no vaccine or treatment, is there a last ditch treatment that could save them?\n\n2. If that last ditch treatment was risky and potentially damaging, would it be ethical to prepare it in advance, in large numbers?\n\nMedical Treatment Questions:\n\n1. If the real problem that causes death in these populations is the patient's strong immune system as it over-responds to the virus (which is attacking every organ in the patient's body) to cause death from shock, then is it reasonable to to restrain the immune system as the at risk patient becomes symptomatic, or even as exposure of the at-risk group is encountered?\n\n2. What are the best means of immuno-suppression? Can at-risk patients be treated with just enough immuno-suppression to limit the shock effect, like a 50% reduction in function across the board? Is it possible to prevent organ damage?\n\n3. If the immune system is suppressed, how long would the at-risk patients need to take antibiotics to protect them from opportunistic infections?\n\n4. They give strong immuno-suppressive drugs to prevent organ-rejection in transplants, is this too drastic of an effect? Can it be reduced reliably?\n\nWorld Health Questions:\n\n1. Since the large numbers of at-risk people around the world are poor, are there immuno-suppressive drugs or environmental (natural) toxins that could be extracted and prepared in large quantities by mass actions (without killing more people than are saved)?\n\n2. Can different treatments potentially be found in the different parts of the world?\n\nImmunosuppressive drugs come in four categories, from (http://en.wikipedia.org/wiki/Immunosuppressive_drug):\n\nImmunosuppressive drugs can be classified into four groups:\n- glucocorticoids\n- cytostatics\n- antibodies\n- drugs acting on immunophilins\n- other drugs\n\nI wonder what the authors would think about this obviously desperate approach?\n\nI can propose desperate measures, because I am a computer systems architect, and am not responsible for anyone's care aside from my own.\n\nCharlie", "isRemoved"=>false, "created"=>"2009-03-30T23:55:11Z", "lastModified"=>"2009-03-30T23:55:11Z", "creator"=>{"userId"=>"172479"}, "highlightedText"=>"", "competingInterestStatement"=>{"creatorWasPrompted"=>true, "hasCompetingInterests"=>false}, "parentArticle"=>{"doi"=>"info:doi/10.1371/journal.pmed.0020359", "state"=>"published", "journals"=>{"PLoSMedicine"=>{"journalKey"=>"PLoSMedicine", "eIssn"=>"1549-1676", "title"=>"PLOS Medicine"}}}, "replyTreeSize"=>0, "mostRecentActivity"=>"2009-03-30T23:55:11Z", "replies"=>[]}
• {"type"=>"COMMENT", "annotationUri"=>"info:doi/10.1371/annotation/6f629d50-3e81-4364-a7a1-794ce23629f0", "title"=>"Preparation for Avian Influenza: what is missing?", "body"=>"Author: Gregory Pappas MD PhD\nPosition: Professor, Chairman\nInstitution: Department of Community Health Sciences, Aga Khan University\nE-mail: gregory.pappas@aku.edu\nSubmitted Date: September 10, 2007\nPublished Date: September 10, 2007\nThis comment was originally posted as a “Reader Response” on the publication date indicated above. All Reader Responses are now available as comments.\n\nWHO has begun what may become the largest coordinated public health effort in history in response to the threat to Avian Influenza. (1) The science and tracking of H5N1 influenza has increased international concern that a deadly pandemic of influenza may be imminent. WHO is now rolling out a global program to create international surveillance and a response to what many consider an impending catastrophe.(2)\n\nRecently the author participated in the roll out in Sudan, a country with may become a front line in the fights against a global pandemic. WHO should be congratulated for development of a well organized approach to educating public health professionals and coordinating with public health agencies. While the response program has rapidly evolved, one aspect is missing from our current approach, an understanding of the politics of influenza.\n\nThe politics of influenza has hampered influenza response measures for decades. Public health professionals need to be educated about this history and the contemporary dynamics of influenza. In the US the politics around influenza have been an impediment and should provide lessons to the global response.\n\nFirst is the politics of an imprecise science. Not everyone agrees that the world is on the breach of a catastrophic influenza pandemic. Communication of risk has a political down side. The politics of industrial chicken production is an emerging driver of the epidemic and creates a new political environment in which we must work. The controversy around culling of poultry is just the beginning of a badly needed discussion on political dimension of our response.\n\nThe politics of pharmaceuticals while well appreciated are avoided by public health professionals. We must work to understand the politics of the global pharmaceutical industry and related policies if we are to succeed. To work with the industry effectively, and we must work with them, we need to be savvy and clear about our objectives.\n\nGlobal equity in the response to influenza needs to be addressed. Mike Davis has called this the Titanic paradigm in which the rich of the world are in the life boards with antiviral drugs and the rest of the world is locked in steerage to perish.(3) Our training programs and our response can not ignore this critical dimension. Finally we must acknowledge and work to understand the politics of vigilance. What if it never happens? What if deadly influenza pandemic never emerges? We should not consider vigilance a failure, but the political fall out must be anticipated and addressed in our planning.\n\nAn effective response to influenza pandemic will require more than a technically excellent program. It will also require a level of political sophistication that we currently are unprepared for. Mike Davis has written an excellent book, “Monster at the Gate” that provides important insights into the politics of influenza that should be part of the basic education we provide to public health professionals. The study of the politics of influenza should become a core component of the preparation and vigilance for the pandemic that has given us ample warning.\n\nReferences\n\n1. J.R. Webby, R.G. Webster, Are We Ready for Pandemic Influenza?\n Science 302 (5650), 1519 (2003)\n\n2. D.J. Barnett, R.D. Balicer, D.R. Lucey, G.S. Everly GS, S.B.Omer SB, et al., A Systematic Analytic Approach to Pandemic Influenza Preparedness Planning. PLoS Med 2(12): e359 (2005) doi:10.1371/journal.pmed.0020359\n\n3. M. Davis, The Monster at Our Door: The Global Threat of the Avian Flu. (New York: Owl Books 2006)", "isRemoved"=>false, "created"=>"2009-03-31T00:13:35Z", "lastModified"=>"2009-03-31T00:13:35Z", "creator"=>{"userId"=>"172479"}, "highlightedText"=>"", "competingInterestStatement"=>{"creatorWasPrompted"=>true, "hasCompetingInterests"=>false}, "parentArticle"=>{"doi"=>"info:doi/10.1371/journal.pmed.0020359", "state"=>"published", "journals"=>{"PLoSMedicine"=>{"journalKey"=>"PLoSMedicine", "eIssn"=>"1549-1676", "title"=>"PLOS Medicine"}}}, "replyTreeSize"=>0, "mostRecentActivity"=>"2009-03-31T00:13:35Z", "replies"=>[]}

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• {"title"=>"File:Historic-Chart-Showing-Mortality-Rates-in-America-and-Europe-during-1918-and-1919-Photo-Image-Reeve-3143-National-Museum.jpg", "url"=>"http://commons.wikimedia.org/wiki/File:Historic-Chart-Showing-Mortality-Rates-in-America-and-Europe-during-1918-and-1919-Photo-Image-Reeve-3143-National-Museum.jpg", "timestamp"=>"2019-02-18T21:37:19Z"}

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Figshare

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• {"files"=>["https://ndownloader.figshare.com/files/961221"], "description"=>"<p>(Photo: Image “NCP 1603,” National Museum of Health and Medicine, Armed Forces Institute of Pathology, Washington, D.C.)</p>", "links"=>[], "tags"=>["1918", "influenza", "united"], "article_id"=>631209, "categories"=>["Biotechnology", "Medicine", "Infectious Diseases"], "users"=>["Daniel J Barnett", "Ran D Balicer", "Daniel R Lucey", "George S Everly Jr", "Saad B Omer", "Mark C Steinhoff", "Itamar Grotto"], "doi"=>"https://dx.doi.org/10.1371/journal.pmed.0020359.g002", "stats"=>{"downloads"=>1, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Emergency_Hospital_during_1918_Influenza_Epidemic_Camp_Funston_Kansas_United_States_/631209", "title"=>"Emergency Hospital during 1918 Influenza Epidemic, Camp Funston, Kansas, United States", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-22 08:55:47"}

PMC Usage Stats | Further Information

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Relative Metric

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F1000Prime