Polyclonal B Cell Differentiation and Loss of Gastrointestinal Tract Germinal Centers in the Earliest Stages of HIV-1 Infection
Events
Loading … Spinner

CiteULike | Further Information

Mendeley | Further Information

{"title"=>"Polyclonal B cell differentiation and loss of gastrointestinal tract germinal centers in the earliest stages of HIV-1 infection", "type"=>"journal", "authors"=>[{"first_name"=>"Marc C.", "last_name"=>"Levesque", "scopus_author_id"=>"7102530754"}, {"first_name"=>"M. Anthony", "last_name"=>"Moody", "scopus_author_id"=>"36096064200"}, {"first_name"=>"Kwan Ki", "last_name"=>"Hwang", "scopus_author_id"=>"7402426470"}, {"first_name"=>"Dawn J.", "last_name"=>"Marshall", "scopus_author_id"=>"16067167000"}, {"first_name"=>"John F.", "last_name"=>"Whitesides", "scopus_author_id"=>"25939112900"}, {"first_name"=>"Joshua D.", "last_name"=>"Amos", "scopus_author_id"=>"35174416500"}, {"first_name"=>"Thaddeus C.", "last_name"=>"Gurley", "scopus_author_id"=>"24398726500"}, {"first_name"=>"Sallie", "last_name"=>"Allgood", "scopus_author_id"=>"23488048700"}, {"first_name"=>"Benjamin B.", "last_name"=>"Haynes", "scopus_author_id"=>"34881578500"}, {"first_name"=>"Nathan A.", "last_name"=>"Vandergrift", "scopus_author_id"=>"16064748500"}, {"first_name"=>"Steven", "last_name"=>"Plonk", "scopus_author_id"=>"57199590481"}, {"first_name"=>"Daniel C.", "last_name"=>"Parker", "scopus_author_id"=>"34882191600"}, {"first_name"=>"Myron S.", "last_name"=>"Cohen", "scopus_author_id"=>"54790532400"}, {"first_name"=>"Georgia D.", "last_name"=>"Tomaras", "scopus_author_id"=>"6507517468"}, {"first_name"=>"Paul A.", "last_name"=>"Goepfert", "scopus_author_id"=>"7004018810"}, {"first_name"=>"George M.", "last_name"=>"Shaw", "scopus_author_id"=>"7401773516"}, {"first_name"=>"Jörn E.", "last_name"=>"Schmitz", "scopus_author_id"=>"55417032300"}, {"first_name"=>"Joseph J.", "last_name"=>"Eron", "scopus_author_id"=>"7006154419"}, {"first_name"=>"Nicholas J.", "last_name"=>"Shaheen", "scopus_author_id"=>"7005212160"}, {"first_name"=>"Charles B.", "last_name"=>"Hicks", "scopus_author_id"=>"7102667305"}, {"first_name"=>"Hua Xin", "last_name"=>"Liao", "scopus_author_id"=>"7201507693"}, {"first_name"=>"Martin", "last_name"=>"Markowitz", "scopus_author_id"=>"7102054379"}, {"first_name"=>"Garnett", "last_name"=>"Kelsoe", "scopus_author_id"=>"7006499118"}, {"first_name"=>"David M.", "last_name"=>"Margolis", "scopus_author_id"=>"14626798300"}, {"first_name"=>"Barton F.", "last_name"=>"Haynes", "scopus_author_id"=>"26430746300"}], "year"=>2009, "source"=>"PLoS Medicine", "identifiers"=>{"pmid"=>"19582166", "sgr"=>"68049135892", "doi"=>"10.1371/journal.pmed.1000107", "scopus"=>"2-s2.0-68049135892", "pui"=>"355033314", "isbn"=>"1549-1676", "issn"=>"15491277"}, "id"=>"99d0bd34-172b-315a-85c5-4b5459c4bf92", "abstract"=>"BACKGROUND: The antibody response to HIV-1 does not appear in the plasma until approximately 2-5 weeks after transmission, and neutralizing antibodies to autologous HIV-1 generally do not become detectable until 12 weeks or more after transmission. Moreover, levels of HIV-1-specific antibodies decline on antiretroviral treatment. The mechanisms of this delay in the appearance of anti-HIV-1 antibodies and of their subsequent rapid decline are not known. While the effect of HIV-1 on depletion of gut CD4(+) T cells in acute HIV-1 infection is well described, we studied blood and tissue B cells soon after infection to determine the effect of early HIV-1 on these cells. METHODS AND FINDINGS: In human participants, we analyzed B cells in blood as early as 17 days after HIV-1 infection, and in terminal ileum inductive and effector microenvironments beginning at 47 days after infection. We found that HIV-1 infection rapidly induced polyclonal activation and terminal differentiation of B cells in blood and in gut-associated lymphoid tissue (GALT) B cells. The specificities of antibodies produced by GALT memory B cells in acute HIV-1 infection (AHI) included not only HIV-1-specific antibodies, but also influenza-specific and autoreactive antibodies, indicating very early onset of HIV-1-induced polyclonal B cell activation. Follicular damage or germinal center loss in terminal ileum Peyer's patches was seen with 88% of follicles exhibiting B or T cell apoptosis and follicular lysis. CONCLUSIONS: Early induction of polyclonal B cell differentiation, coupled with follicular damage and germinal center loss soon after HIV-1 infection, may explain both the high rate of decline in HIV-1-induced antibody responses and the delay in plasma antibody responses to HIV-1. Please see later in the article for Editors' Summary.", "link"=>"http://www.mendeley.com/research/polyclonal-b-cell-differentiation-loss-gastrointestinal-tract-germinal-centers-earliest-stages-hiv1", "reader_count"=>81, "reader_count_by_academic_status"=>{"Unspecified"=>2, "Professor > Associate Professor"=>2, "Researcher"=>27, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>20, "Student > Postgraduate"=>5, "Student > Master"=>10, "Other"=>4, "Student > Bachelor"=>5, "Lecturer > Senior Lecturer"=>1, "Professor"=>3}, "reader_count_by_user_role"=>{"Unspecified"=>2, "Professor > Associate Professor"=>2, "Researcher"=>27, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>20, "Student > Postgraduate"=>5, "Student > Master"=>10, "Other"=>4, "Student > Bachelor"=>5, "Lecturer > Senior Lecturer"=>1, "Professor"=>3}, "reader_count_by_subject_area"=>{"Unspecified"=>3, "Engineering"=>2, "Biochemistry, Genetics and Molecular Biology"=>1, "Agricultural and Biological Sciences"=>39, "Medicine and Dentistry"=>29, "Veterinary Science and Veterinary Medicine"=>2, "Immunology and Microbiology"=>5}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>2}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>29}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>5}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>39}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>1}, "Unspecified"=>{"Unspecified"=>3}, "Veterinary Science and Veterinary Medicine"=>{"Veterinary Science and Veterinary Medicine"=>2}}, "reader_count_by_country"=>{"Canada"=>1, "Belgium"=>1, "United States"=>3, "South Africa"=>1, "Italy"=>1, "United Kingdom"=>1, "France"=>1}, "group_count"=>3}

CrossRef

Scopus | Further Information

{"@_fa"=>"true", "link"=>[{"@_fa"=>"true", "@ref"=>"self", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/68049135892"}, {"@_fa"=>"true", "@ref"=>"author-affiliation", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/68049135892?field=author,affiliation"}, {"@_fa"=>"true", "@ref"=>"scopus", "@href"=>"https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=68049135892&origin=inward"}, {"@_fa"=>"true", "@ref"=>"scopus-citedby", "@href"=>"https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=68049135892&origin=inward"}], "prism:url"=>"https://api.elsevier.com/content/abstract/scopus_id/68049135892", "dc:identifier"=>"SCOPUS_ID:68049135892", "eid"=>"2-s2.0-68049135892", "dc:title"=>"Polyclonal B cell differentiation and loss of gastrointestinal tract germinal centers in the earliest stages of HIV-1 infection", "dc:creator"=>"Levesque M.", "prism:publicationName"=>"PLoS Medicine", "prism:issn"=>"15491277", "prism:eIssn"=>"15491676", "prism:volume"=>"6", "prism:issueIdentifier"=>"7", "prism:pageRange"=>nil, "prism:coverDate"=>"2009-07-01", "prism:coverDisplayDate"=>"July 2009", "prism:doi"=>"10.1371/journal.pmed.1000107", "citedby-count"=>"122", "affiliation"=>[{"@_fa"=>"true", "affilname"=>"Duke University School of Medicine", "affiliation-city"=>"Durham", "affiliation-country"=>"United States"}], "pubmed-id"=>"19582166", "prism:aggregationType"=>"Journal", "subtype"=>"ar", "subtypeDescription"=>"Article", "article-number"=>"e1000107", "source-id"=>"144840", "openaccess"=>"1", "openaccessFlag"=>true}

Facebook

  • {"url"=>"http%3A%2F%2Fjournals.plos.org%2Fplosmedicine%2Farticle%3Fid%3D10.1371%252Fjournal.pmed.1000107", "share_count"=>0, "like_count"=>0, "comment_count"=>0, "click_count"=>0, "total_count"=>0}

Counter

  • {"month"=>"7", "year"=>"2009", "pdf_views"=>"470", "xml_views"=>"6", "html_views"=>"1476"}
  • {"month"=>"8", "year"=>"2009", "pdf_views"=>"128", "xml_views"=>"1", "html_views"=>"390"}
  • {"month"=>"9", "year"=>"2009", "pdf_views"=>"46", "xml_views"=>"0", "html_views"=>"208"}
  • {"month"=>"10", "year"=>"2009", "pdf_views"=>"44", "xml_views"=>"1", "html_views"=>"175"}
  • {"month"=>"11", "year"=>"2009", "pdf_views"=>"41", "xml_views"=>"0", "html_views"=>"149"}
  • {"month"=>"12", "year"=>"2009", "pdf_views"=>"39", "xml_views"=>"3", "html_views"=>"144"}
  • {"month"=>"1", "year"=>"2010", "pdf_views"=>"35", "xml_views"=>"1", "html_views"=>"156"}
  • {"month"=>"2", "year"=>"2010", "pdf_views"=>"31", "xml_views"=>"0", "html_views"=>"126"}
  • {"month"=>"3", "year"=>"2010", "pdf_views"=>"26", "xml_views"=>"0", "html_views"=>"150"}
  • {"month"=>"4", "year"=>"2010", "pdf_views"=>"30", "xml_views"=>"3", "html_views"=>"143"}
  • {"month"=>"5", "year"=>"2010", "pdf_views"=>"38", "xml_views"=>"0", "html_views"=>"163"}
  • {"month"=>"6", "year"=>"2010", "pdf_views"=>"24", "xml_views"=>"0", "html_views"=>"169"}
  • {"month"=>"7", "year"=>"2010", "pdf_views"=>"22", "xml_views"=>"0", "html_views"=>"137"}
  • {"month"=>"8", "year"=>"2010", "pdf_views"=>"25", "xml_views"=>"1", "html_views"=>"133"}
  • {"month"=>"9", "year"=>"2010", "pdf_views"=>"31", "xml_views"=>"1", "html_views"=>"186"}
  • {"month"=>"10", "year"=>"2010", "pdf_views"=>"18", "xml_views"=>"1", "html_views"=>"191"}
  • {"month"=>"11", "year"=>"2010", "pdf_views"=>"24", "xml_views"=>"0", "html_views"=>"228"}
  • {"month"=>"12", "year"=>"2010", "pdf_views"=>"17", "xml_views"=>"1", "html_views"=>"240"}
  • {"month"=>"1", "year"=>"2011", "pdf_views"=>"23", "xml_views"=>"2", "html_views"=>"195"}
  • {"month"=>"2", "year"=>"2011", "pdf_views"=>"14", "xml_views"=>"0", "html_views"=>"185"}
  • {"month"=>"3", "year"=>"2011", "pdf_views"=>"21", "xml_views"=>"0", "html_views"=>"91"}
  • {"month"=>"4", "year"=>"2011", "pdf_views"=>"14", "xml_views"=>"0", "html_views"=>"60"}
  • {"month"=>"5", "year"=>"2011", "pdf_views"=>"14", "xml_views"=>"1", "html_views"=>"31"}
  • {"month"=>"6", "year"=>"2011", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"30"}
  • {"month"=>"7", "year"=>"2011", "pdf_views"=>"14", "xml_views"=>"0", "html_views"=>"29"}
  • {"month"=>"8", "year"=>"2011", "pdf_views"=>"13", "xml_views"=>"1", "html_views"=>"45"}
  • {"month"=>"9", "year"=>"2011", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"35"}
  • {"month"=>"10", "year"=>"2011", "pdf_views"=>"16", "xml_views"=>"0", "html_views"=>"36"}
  • {"month"=>"11", "year"=>"2011", "pdf_views"=>"15", "xml_views"=>"0", "html_views"=>"61"}
  • {"month"=>"12", "year"=>"2011", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"53"}
  • {"month"=>"1", "year"=>"2012", "pdf_views"=>"14", "xml_views"=>"0", "html_views"=>"50"}
  • {"month"=>"2", "year"=>"2012", "pdf_views"=>"15", "xml_views"=>"0", "html_views"=>"65"}
  • {"month"=>"3", "year"=>"2012", "pdf_views"=>"11", "xml_views"=>"1", "html_views"=>"65"}
  • {"month"=>"4", "year"=>"2012", "pdf_views"=>"16", "xml_views"=>"1", "html_views"=>"54"}
  • {"month"=>"5", "year"=>"2012", "pdf_views"=>"19", "xml_views"=>"2", "html_views"=>"56"}
  • {"month"=>"6", "year"=>"2012", "pdf_views"=>"6", "xml_views"=>"1", "html_views"=>"44"}
  • {"month"=>"7", "year"=>"2012", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"53"}
  • {"month"=>"8", "year"=>"2012", "pdf_views"=>"11", "xml_views"=>"6", "html_views"=>"97"}
  • {"month"=>"9", "year"=>"2012", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"43"}
  • {"month"=>"10", "year"=>"2012", "pdf_views"=>"12", "xml_views"=>"1", "html_views"=>"84"}
  • {"month"=>"11", "year"=>"2012", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"64"}
  • {"month"=>"12", "year"=>"2012", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"49"}
  • {"month"=>"1", "year"=>"2013", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"69"}
  • {"month"=>"2", "year"=>"2013", "pdf_views"=>"11", "xml_views"=>"3", "html_views"=>"62"}
  • {"month"=>"3", "year"=>"2013", "pdf_views"=>"16", "xml_views"=>"2", "html_views"=>"72"}
  • {"month"=>"4", "year"=>"2013", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"104"}
  • {"month"=>"5", "year"=>"2013", "pdf_views"=>"26", "xml_views"=>"0", "html_views"=>"88"}
  • {"month"=>"6", "year"=>"2013", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"54"}
  • {"month"=>"7", "year"=>"2013", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"49"}
  • {"month"=>"8", "year"=>"2013", "pdf_views"=>"13", "xml_views"=>"1", "html_views"=>"46"}
  • {"month"=>"9", "year"=>"2013", "pdf_views"=>"20", "xml_views"=>"1", "html_views"=>"84"}
  • {"month"=>"10", "year"=>"2013", "pdf_views"=>"6", "xml_views"=>"1", "html_views"=>"203"}
  • {"month"=>"11", "year"=>"2013", "pdf_views"=>"9", "xml_views"=>"2", "html_views"=>"224"}
  • {"month"=>"12", "year"=>"2013", "pdf_views"=>"8", "xml_views"=>"1", "html_views"=>"173"}
  • {"month"=>"1", "year"=>"2014", "pdf_views"=>"14", "xml_views"=>"0", "html_views"=>"181"}
  • {"month"=>"2", "year"=>"2014", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"173"}
  • {"month"=>"3", "year"=>"2014", "pdf_views"=>"6", "xml_views"=>"2", "html_views"=>"258"}
  • {"month"=>"4", "year"=>"2014", "pdf_views"=>"21", "xml_views"=>"1", "html_views"=>"213"}
  • {"month"=>"5", "year"=>"2014", "pdf_views"=>"14", "xml_views"=>"0", "html_views"=>"176"}
  • {"month"=>"6", "year"=>"2014", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"191"}
  • {"month"=>"7", "year"=>"2014", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"96"}
  • {"month"=>"8", "year"=>"2014", "pdf_views"=>"6", "xml_views"=>"3", "html_views"=>"73"}
  • {"month"=>"9", "year"=>"2014", "pdf_views"=>"4", "xml_views"=>"1", "html_views"=>"110"}
  • {"month"=>"10", "year"=>"2014", "pdf_views"=>"10", "xml_views"=>"1", "html_views"=>"181"}
  • {"month"=>"11", "year"=>"2014", "pdf_views"=>"7", "xml_views"=>"1", "html_views"=>"160"}
  • {"month"=>"12", "year"=>"2014", "pdf_views"=>"11", "xml_views"=>"2", "html_views"=>"127"}
  • {"month"=>"1", "year"=>"2015", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"81"}
  • {"month"=>"2", "year"=>"2015", "pdf_views"=>"18", "xml_views"=>"0", "html_views"=>"33"}
  • {"month"=>"3", "year"=>"2015", "pdf_views"=>"50", "xml_views"=>"1", "html_views"=>"36"}
  • {"month"=>"4", "year"=>"2015", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"41"}
  • {"month"=>"5", "year"=>"2015", "pdf_views"=>"7", "xml_views"=>"1", "html_views"=>"38"}
  • {"month"=>"6", "year"=>"2015", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"44"}
  • {"month"=>"7", "year"=>"2015", "pdf_views"=>"44", "xml_views"=>"0", "html_views"=>"23"}
  • {"month"=>"8", "year"=>"2015", "pdf_views"=>"2", "xml_views"=>"1", "html_views"=>"23"}
  • {"month"=>"9", "year"=>"2015", "pdf_views"=>"0", "xml_views"=>"0", "html_views"=>"30"}
  • {"month"=>"10", "year"=>"2015", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"35"}
  • {"month"=>"11", "year"=>"2015", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"24"}
  • {"month"=>"12", "year"=>"2015", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"33"}
  • {"month"=>"1", "year"=>"2016", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"56"}
  • {"month"=>"2", "year"=>"2016", "pdf_views"=>"26", "xml_views"=>"1", "html_views"=>"52"}
  • {"month"=>"3", "year"=>"2016", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"88"}
  • {"month"=>"4", "year"=>"2016", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"93"}
  • {"month"=>"5", "year"=>"2016", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"73"}
  • {"month"=>"6", "year"=>"2016", "pdf_views"=>"16", "xml_views"=>"0", "html_views"=>"71"}
  • {"month"=>"7", "year"=>"2016", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"23"}
  • {"month"=>"8", "year"=>"2016", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"46"}
  • {"month"=>"9", "year"=>"2016", "pdf_views"=>"18", "xml_views"=>"0", "html_views"=>"89"}
  • {"month"=>"10", "year"=>"2016", "pdf_views"=>"21", "xml_views"=>"0", "html_views"=>"38"}
  • {"month"=>"11", "year"=>"2016", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"22"}
  • {"month"=>"12", "year"=>"2016", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"21"}
  • {"month"=>"1", "year"=>"2017", "pdf_views"=>"12", "xml_views"=>"1", "html_views"=>"30"}
  • {"month"=>"2", "year"=>"2017", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"26"}
  • {"month"=>"3", "year"=>"2017", "pdf_views"=>"16", "xml_views"=>"0", "html_views"=>"35"}
  • {"month"=>"4", "year"=>"2017", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"56"}
  • {"month"=>"5", "year"=>"2017", "pdf_views"=>"10", "xml_views"=>"1", "html_views"=>"45"}
  • {"month"=>"6", "year"=>"2017", "pdf_views"=>"15", "xml_views"=>"1", "html_views"=>"44"}
  • {"month"=>"7", "year"=>"2017", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"21"}
  • {"month"=>"8", "year"=>"2017", "pdf_views"=>"6", "xml_views"=>"1", "html_views"=>"23"}
  • {"month"=>"9", "year"=>"2017", "pdf_views"=>"8", "xml_views"=>"2", "html_views"=>"20"}
  • {"month"=>"10", "year"=>"2017", "pdf_views"=>"7", "xml_views"=>"2", "html_views"=>"30"}
  • {"month"=>"11", "year"=>"2017", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"25"}
  • {"month"=>"12", "year"=>"2017", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"36"}
  • {"month"=>"1", "year"=>"2018", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"13"}
  • {"month"=>"2", "year"=>"2018", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"8"}
  • {"month"=>"3", "year"=>"2018", "pdf_views"=>"15", "xml_views"=>"0", "html_views"=>"21"}
  • {"month"=>"4", "year"=>"2018", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"12"}
  • {"month"=>"5", "year"=>"2018", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"6"}
  • {"month"=>"6", "year"=>"2018", "pdf_views"=>"6", "xml_views"=>"5", "html_views"=>"7"}
  • {"month"=>"7", "year"=>"2018", "pdf_views"=>"3", "xml_views"=>"5", "html_views"=>"7"}
  • {"month"=>"8", "year"=>"2018", "pdf_views"=>"5", "xml_views"=>"1", "html_views"=>"8"}
  • {"month"=>"9", "year"=>"2018", "pdf_views"=>"12", "xml_views"=>"1", "html_views"=>"9"}
  • {"month"=>"10", "year"=>"2018", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"11"}
  • {"month"=>"11", "year"=>"2018", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"11"}
  • {"month"=>"12", "year"=>"2018", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"10"}
  • {"month"=>"1", "year"=>"2019", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"7"}
  • {"month"=>"2", "year"=>"2019", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"6"}
  • {"month"=>"3", "year"=>"2019", "pdf_views"=>"7", "xml_views"=>"1", "html_views"=>"13"}
  • {"month"=>"4", "year"=>"2019", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"8"}
  • {"month"=>"5", "year"=>"2019", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"7"}
  • {"month"=>"6", "year"=>"2019", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"17"}
  • {"month"=>"7", "year"=>"2019", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"7"}
  • {"month"=>"8", "year"=>"2019", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"3"}

Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/893354"], "description"=>"a<p>Duration of ART mean 31 d, range 14–63 d.</p>b<p>Two-tailed Fisher's exact test for AHI total versus uninfected comparison.</p>", "links"=>[], "tags"=>["acute", "hiv-1"], "article_id"=>563777, "categories"=>["Immunology", "Medicine"], "users"=>["Marc C. Levesque", "M. Anthony Moody", "Kwan-Ki Hwang", "Dawn J. Marshall", "John F. Whitesides", "Joshua D. Amos", "Thaddeus C. Gurley", "Sallie Allgood", "Benjamin B. Haynes", "Nathan A. Vandergrift", "Steven Plonk", "Daniel C. Parker", "Myron S. Cohen", "Georgia D. Tomaras", "Paul A. Goepfert", "George M. Shaw", "Jörn E. Schmitz", "Joseph J. Eron", "Nicholas J. Shaheen", "Charles B. Hicks", "Hua-Xin Liao", "Martin Markowitz", "Garnett Kelsoe", "David M. Margolis", "Barton F. Haynes"], "doi"=>"https://dx.doi.org/10.1371/journal.pmed.1000107.t003", "stats"=>{"downloads"=>0, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Germinal_center_damage_in_acute_HIV_1_infection_/563777", "title"=>"Germinal center damage in acute HIV-1 infection.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2009-07-07 01:02:57"}
  • {"files"=>["https://ndownloader.figshare.com/files/892900"], "description"=>"<p>For all analyses, B cells were identified as CD3<sup>−</sup> CD14<sup>−</sup> CD16<sup>−</sup> CD235a<sup>−</sup> and CD19<sup>+</sup>. Horizontal lines show mean values; error bars show standard error of the mean. (A) Terminal ileal naïve B cell percentages. Naïve B cells were defined as B cells that were also surface IgD<sup>+</sup> and CD27<sup>−</sup>. In cells from terminal ileal biopsies, uninfected participants had a mean±standard error of the mean 29.9%±7.0% of naïve B cells that were decreased to 15.7%±8.9% in AHI patients. (B) Terminal ileal memory and plasma cell percentages. Memory B and plasma cells were defined as B cells that were also surface IgD<sup>−</sup> and CD27<sup>+</sup>, leaving out IgD<sup>+</sup> IgM<sup>+</sup> CD27<sup>+</sup> B cells. In terminal ileum, uninfected participants had 17.1%±5.8% of memory B and plasma cells that were increased to 36.4%±6.9% in AHI patients (<i>p</i> = 0.047, <i>t</i>-test). (C) Peripheral blood naïve B cell percentages. Uninfected participants had 71.1%±2.9% of naïve B cells that were decreased to 49.7%±4.2% in AHI patients (<i>p</i> = 0.0001, <i>t</i>-test). (D) Peripheral blood IgD<sup>−</sup> CD27<sup>+</sup> memory and plasma cell percentages. Uninfected individuals had 9.4%±1.9% of memory B and plasma cells that were increased to 20.2%±2.6% in AHI patients (<i>p</i> = 0.0003, <i>t</i>-test). (E) Absolute numbers of circulating peripheral blood naïve B cells. Calculated as absolute naïve B cells per microliter of blood, uninfected participants had 169±23 cells/µl, while AHI patients had 148±48 cells/µl. (F) Absolute circulating memory B and plasma cells. Calculated as absolute number of cells per microliter of blood, uninfected individuals had 21.6±4.4 cells/µl, and 36.0±4.4 cells/µl in AHI participants (<i>p</i> = 0.03, <i>t</i>-test). All data in this figure were also analyzed using a two-tailed exact Wilcoxon test that resulted in similar <i>p</i>-values.</p>", "links"=>[], "tags"=>["cytometric"], "article_id"=>563333, "categories"=>["Immunology", "Medicine"], "users"=>["Marc C. Levesque", "M. Anthony Moody", "Kwan-Ki Hwang", "Dawn J. Marshall", "John F. Whitesides", "Joshua D. Amos", "Thaddeus C. Gurley", "Sallie Allgood", "Benjamin B. Haynes", "Nathan A. Vandergrift", "Steven Plonk", "Daniel C. Parker", "Myron S. Cohen", "Georgia D. Tomaras", "Paul A. Goepfert", "George M. Shaw", "Jörn E. Schmitz", "Joseph J. Eron", "Nicholas J. Shaheen", "Charles B. Hicks", "Hua-Xin Liao", "Martin Markowitz", "Garnett Kelsoe", "David M. Margolis", "Barton F. Haynes"], "doi"=>"https://dx.doi.org/10.1371/journal.pmed.1000107.g008", "stats"=>{"downloads"=>0, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Flow_cytometric_analysis_of_B_cell_populations_/563333", "title"=>"Flow cytometric analysis of B cell populations.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2009-07-07 00:55:33"}
  • {"files"=>["https://ndownloader.figshare.com/files/893418"], "description"=>"<p>There were 14 uninfected control participants who contributed peripheral blood (36% male, mean age 33.5 y [range18–66 y]).</p>a<p>All participants herein received efavirenz, tenofovir, and emtricitibine daily.</p>b<p>Viral load comparisons reported as geometric means and were different between on and off ART groups (<i>p</i> = 0.035, <i>t</i>-test).</p><p>N/A, not applicable; NR, not reported.</p>", "links"=>[], "tags"=>["contributed", "peripheral"], "article_id"=>563848, "categories"=>["Immunology", "Medicine"], "users"=>["Marc C. Levesque", "M. Anthony Moody", "Kwan-Ki Hwang", "Dawn J. Marshall", "John F. Whitesides", "Joshua D. Amos", "Thaddeus C. Gurley", "Sallie Allgood", "Benjamin B. Haynes", "Nathan A. Vandergrift", "Steven Plonk", "Daniel C. Parker", "Myron S. Cohen", "Georgia D. Tomaras", "Paul A. Goepfert", "George M. Shaw", "Jörn E. Schmitz", "Joseph J. Eron", "Nicholas J. Shaheen", "Charles B. Hicks", "Hua-Xin Liao", "Martin Markowitz", "Garnett Kelsoe", "David M. Margolis", "Barton F. Haynes"], "doi"=>"https://dx.doi.org/10.1371/journal.pmed.1000107.t002", "stats"=>{"downloads"=>0, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Participants_who_contributed_peripheral_blood_/563848", "title"=>"Participants who contributed peripheral blood.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2009-07-07 01:04:08"}
  • {"files"=>["https://ndownloader.figshare.com/files/893486"], "description"=>"<p>Tissues from nine uninfected participants were obtained as terminal ileal biopsies from healthy volunteers or as discarded specimens from surgeries for colon cancer, colon polyps, carcinoid tumor, and endometriosis.</p>a<p>Participants with GALT germinal centers indicated by italics.</p>b<p>All participants herein received efavirenz, tenofovir, and emtricitibine daily.</p>c<p>Viral load comparisons reported as geometric means.</p><p>N/A, not applicable; NR, not reported.</p>", "links"=>[], "tags"=>["contributed", "terminal", "ileum"], "article_id"=>563913, "categories"=>["Immunology", "Medicine"], "users"=>["Marc C. Levesque", "M. Anthony Moody", "Kwan-Ki Hwang", "Dawn J. Marshall", "John F. Whitesides", "Joshua D. Amos", "Thaddeus C. Gurley", "Sallie Allgood", "Benjamin B. Haynes", "Nathan A. Vandergrift", "Steven Plonk", "Daniel C. Parker", "Myron S. Cohen", "Georgia D. Tomaras", "Paul A. Goepfert", "George M. Shaw", "Jörn E. Schmitz", "Joseph J. Eron", "Nicholas J. Shaheen", "Charles B. Hicks", "Hua-Xin Liao", "Martin Markowitz", "Garnett Kelsoe", "David M. Margolis", "Barton F. Haynes"], "doi"=>"https://dx.doi.org/10.1371/journal.pmed.1000107.t001", "stats"=>{"downloads"=>0, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Participants_who_contributed_terminal_ileum_tissues_/563913", "title"=>"Participants who contributed terminal ileum tissues.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2009-07-07 01:05:13"}
  • {"files"=>["https://ndownloader.figshare.com/files/891709"], "description"=>"<p>Lamina propria B cell apoptosis with CD11c<sup>+</sup> macrophage infiltration in participant 015-5, 55 d after transmission, on ART 15 d. A cluster of lamina propria B cells (A; arrows), TUNEL stain of the same area with arrows pointing out brown apoptotic nuclei (B), and the same area with infiltrating CD11c<sup>+</sup> macrophages (C) (100×).</p>", "links"=>[], "tags"=>["hiv-1", "cells", "terminal", "ileum", "lamina"], "article_id"=>562132, "categories"=>["Immunology", "Medicine"], "users"=>["Marc C. Levesque", "M. Anthony Moody", "Kwan-Ki Hwang", "Dawn J. Marshall", "John F. Whitesides", "Joshua D. Amos", "Thaddeus C. Gurley", "Sallie Allgood", "Benjamin B. Haynes", "Nathan A. Vandergrift", "Steven Plonk", "Daniel C. Parker", "Myron S. Cohen", "Georgia D. Tomaras", "Paul A. Goepfert", "George M. Shaw", "Jörn E. Schmitz", "Joseph J. Eron", "Nicholas J. Shaheen", "Charles B. Hicks", "Hua-Xin Liao", "Martin Markowitz", "Garnett Kelsoe", "David M. Margolis", "Barton F. Haynes"], "doi"=>"https://dx.doi.org/10.1371/journal.pmed.1000107.g001", "stats"=>{"downloads"=>0, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Effect_of_HIV_1_on_B_cells_in_terminal_ileum_lamina_propria_/562132", "title"=>"Effect of HIV-1 on B cells in terminal ileum lamina propria.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2009-07-07 00:35:32"}
  • {"files"=>["https://ndownloader.figshare.com/files/892031"], "description"=>"<p>A near-normal terminal ileal secondary follicle in patient 018-4, 74 d after transmission, on ART 29 d (20×). (A) CD20<sup>+</sup> B cells; (B) Ki-67<sup>+</sup> dividing germinal center B cells; (C) subepithelial CD3<sup>+</sup> T cells and a small area of infiltrating CD3<sup>+</sup> T cells in the marginal zone around the germinal center (arrow); (D) normal-appearing CD11c<sup>+</sup> macrophages and dendritic cells (arrow). TUNEL stain was negative for apoptotic nuclei (unpublished data).</p>", "links"=>[], "tags"=>["morphology", "follicle", "ahi", "terminal"], "article_id"=>562458, "categories"=>["Immunology", "Medicine"], "users"=>["Marc C. Levesque", "M. Anthony Moody", "Kwan-Ki Hwang", "Dawn J. Marshall", "John F. Whitesides", "Joshua D. Amos", "Thaddeus C. Gurley", "Sallie Allgood", "Benjamin B. Haynes", "Nathan A. Vandergrift", "Steven Plonk", "Daniel C. Parker", "Myron S. Cohen", "Georgia D. Tomaras", "Paul A. Goepfert", "George M. Shaw", "Jörn E. Schmitz", "Joseph J. Eron", "Nicholas J. Shaheen", "Charles B. Hicks", "Hua-Xin Liao", "Martin Markowitz", "Garnett Kelsoe", "David M. Margolis", "Barton F. Haynes"], "doi"=>"https://dx.doi.org/10.1371/journal.pmed.1000107.g003", "stats"=>{"downloads"=>0, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Nearly_normal_morphology_of_secondary_follicle_in_AHI_terminal_ileum_/562458", "title"=>"Nearly normal morphology of secondary follicle in AHI terminal ileum.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2009-07-07 00:40:58"}
  • {"files"=>["https://ndownloader.figshare.com/files/893290"], "description"=>"<p>Table shows the percentage of wells of terminal ileum cells seeded at 10<sup>4</sup> cells/well and assayed 21–28 d after EBV transformation. Percentages represent positive wells out of number of cultures indicated that were assayed for antibodies reactive with gp41, gp120, Tat, CL, and killed influenza in the 2007 influenza vaccine Fluzone, as well as RF. The comparison group was a total of 420 cultures from four uninfected participants.</p>", "links"=>[], "tags"=>["eb", "virus-stimulated", "cultures", "producing", "antibodies", "reactive", "hiv", "non-hiv"], "article_id"=>563706, "categories"=>["Immunology", "Medicine"], "users"=>["Marc C. Levesque", "M. Anthony Moody", "Kwan-Ki Hwang", "Dawn J. Marshall", "John F. Whitesides", "Joshua D. Amos", "Thaddeus C. Gurley", "Sallie Allgood", "Benjamin B. Haynes", "Nathan A. Vandergrift", "Steven Plonk", "Daniel C. Parker", "Myron S. Cohen", "Georgia D. Tomaras", "Paul A. Goepfert", "George M. Shaw", "Jörn E. Schmitz", "Joseph J. Eron", "Nicholas J. Shaheen", "Charles B. Hicks", "Hua-Xin Liao", "Martin Markowitz", "Garnett Kelsoe", "David M. Margolis", "Barton F. Haynes"], "doi"=>"https://dx.doi.org/10.1371/journal.pmed.1000107.t004", "stats"=>{"downloads"=>0, "page_views"=>14, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Percentage_of_EB_virus_stimulated_cultures_producing_antibodies_reactive_with_HIV_and_non_HIV_antigens_/563706", "title"=>"Percentage of EB virus-stimulated cultures producing antibodies reactive with HIV and non-HIV antigens.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2009-07-07 01:01:46"}
  • {"files"=>["https://ndownloader.figshare.com/files/892610"], "description"=>"<p>(A–D) 20×; (E–H) 40×. (A and E) The fine reticular network of FDCs in an uninfected terminal ileum Peyer's patch (stained with p75 nerve growth factor receptor monoclonal antibody NGFR5). (B and F) Typical hyperplastic FDCs in patient 018-4, 74 d after transmission (stained with NGFR5 monoclonal antibody). (C) (stained with CD21 monoclonal antibody 1F8) and (G) (stained with CD35 monoclonal antibody BerMAC) show condensation and early loss of FDC in AHI terminal ileum 010-1, 52 d after transmission. (D) (stained with NGFR5 monoclonal antibody) and (H) (stained with CD35 monoclonal antibody BerMAC) show progressive FDC destruction in terminal ileum 025-7, 105 d after transmission.</p>", "links"=>[], "tags"=>["immunology/immune response", "immunology/immunity to infections", "infectious diseases/hiv infection and aids"], "article_id"=>563042, "categories"=>["Immunology", "Medicine"], "users"=>["Marc C. Levesque", "M. Anthony Moody", "Kwan-Ki Hwang", "Dawn J. Marshall", "John F. Whitesides", "Joshua D. Amos", "Thaddeus C. Gurley", "Sallie Allgood", "Benjamin B. Haynes", "Nathan A. Vandergrift", "Steven Plonk", "Daniel C. Parker", "Myron S. Cohen", "Georgia D. Tomaras", "Paul A. Goepfert", "George M. Shaw", "Jörn E. Schmitz", "Joseph J. Eron", "Nicholas J. Shaheen", "Charles B. Hicks", "Hua-Xin Liao", "Martin Markowitz", "Garnett Kelsoe", "David M. Margolis", "Barton F. Haynes"], "doi"=>"https://dx.doi.org/10.1371/journal.pmed.1000107.g006", "stats"=>{"downloads"=>0, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Changes_in_FDCs_in_AHI_/563042", "title"=>"Changes in FDCs) in AHI.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2009-07-07 00:50:42"}
  • {"files"=>["https://ndownloader.figshare.com/files/893007"], "description"=>"<p>Horizontal lines show mean values; error bars show standard error of the mean. Graph shows the levels of IgA, IgG, and IgM in the cell culture supernatants derived from terminal ileal samples of six acute/early HIV-infected and six uninfected participants determined by ELISA 14 d after EBV transformation. Each data point represents the geometric mean of IgA, IgG, and IgM levels in all wells plated from each terminal ileum sample.</p>", "links"=>[], "tags"=>["immunoglobulin", "levels", "specificities", "ebv-transformed"], "article_id"=>563433, "categories"=>["Immunology", "Medicine"], "users"=>["Marc C. Levesque", "M. Anthony Moody", "Kwan-Ki Hwang", "Dawn J. Marshall", "John F. Whitesides", "Joshua D. Amos", "Thaddeus C. Gurley", "Sallie Allgood", "Benjamin B. Haynes", "Nathan A. Vandergrift", "Steven Plonk", "Daniel C. Parker", "Myron S. Cohen", "Georgia D. Tomaras", "Paul A. Goepfert", "George M. Shaw", "Jörn E. Schmitz", "Joseph J. Eron", "Nicholas J. Shaheen", "Charles B. Hicks", "Hua-Xin Liao", "Martin Markowitz", "Garnett Kelsoe", "David M. Margolis", "Barton F. Haynes"], "doi"=>"https://dx.doi.org/10.1371/journal.pmed.1000107.g009", "stats"=>{"downloads"=>0, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Total_immunoglobulin_Ig_levels_and_specificities_in_the_EBV_transformed_B_cell_cultures_/563433", "title"=>"Total immunoglobulin (Ig) levels and specificities in the EBV-transformed B cell cultures.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2009-07-07 00:57:13"}
  • {"files"=>["https://ndownloader.figshare.com/files/891857"], "description"=>"<p>Serial sections of the same Peyer's patch follicle in an uninfected terminal ileum (20×). (A) CD20<sup>+</sup> B cells in a secondary follicle with germinal center (g). (B) The same follicle with TUNEL staining showing that the predominant apoptotic cells are within tingible body macrophages (insert). (C) Ki-67<sup>+</sup> dividing B cells. (D) CD11c<sup>+</sup> follicular dendritic cells and macrophages. (E) CD68<sup>+</sup> macrophages and dendritic cells in the subepithelial zone below follicular associated epithelial cells (arrow, top of photomicrograph) at the dome of the Peyer's patch, and CD68<sup>+</sup> tingible body macrophages in the germinal center (insert). (F) CD16<sup>+</sup> NK cells clustered in the areas below follicle associated epithelial cells (arrow).</p>", "links"=>[], "tags"=>["uninfected", "terminal", "ileum"], "article_id"=>562284, "categories"=>["Immunology", "Medicine"], "users"=>["Marc C. Levesque", "M. Anthony Moody", "Kwan-Ki Hwang", "Dawn J. Marshall", "John F. Whitesides", "Joshua D. Amos", "Thaddeus C. Gurley", "Sallie Allgood", "Benjamin B. Haynes", "Nathan A. Vandergrift", "Steven Plonk", "Daniel C. Parker", "Myron S. Cohen", "Georgia D. Tomaras", "Paul A. Goepfert", "George M. Shaw", "Jörn E. Schmitz", "Joseph J. Eron", "Nicholas J. Shaheen", "Charles B. Hicks", "Hua-Xin Liao", "Martin Markowitz", "Garnett Kelsoe", "David M. Margolis", "Barton F. Haynes"], "doi"=>"https://dx.doi.org/10.1371/journal.pmed.1000107.g002", "stats"=>{"downloads"=>0, "page_views"=>2, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Morphology_of_uninfected_terminal_ileum_Peyer_s_patch_B_cell_8211_inductive_microenvironments_/562284", "title"=>"Morphology of uninfected terminal ileum Peyer's patch B cell–inductive microenvironments.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2009-07-07 00:38:04"}
  • {"files"=>["https://ndownloader.figshare.com/files/442014", "https://ndownloader.figshare.com/files/442049", "https://ndownloader.figshare.com/files/442082", "https://ndownloader.figshare.com/files/442118", "https://ndownloader.figshare.com/files/442153", "https://ndownloader.figshare.com/files/442194", "https://ndownloader.figshare.com/files/442240", "https://ndownloader.figshare.com/files/442273"], "description"=>"<div><h3>Background</h3><p>The antibody response to HIV-1 does not appear in the plasma until approximately 2–5 weeks after transmission, and neutralizing antibodies to autologous HIV-1 generally do not become detectable until 12 weeks or more after transmission. Moreover, levels of HIV-1–specific antibodies decline on antiretroviral treatment. The mechanisms of this delay in the appearance of anti-HIV-1 antibodies and of their subsequent rapid decline are not known. While the effect of HIV-1 on depletion of gut CD4<sup>+</sup> T cells in acute HIV-1 infection is well described, we studied blood and tissue B cells soon after infection to determine the effect of early HIV-1 on these cells.</p><h3>Methods and Findings</h3><p>In human participants, we analyzed B cells in blood as early as 17 days after HIV-1 infection, and in terminal ileum inductive and effector microenvironments beginning at 47 days after infection. We found that HIV-1 infection rapidly induced polyclonal activation and terminal differentiation of B cells in blood and in gut-associated lymphoid tissue (GALT) B cells. The specificities of antibodies produced by GALT memory B cells in acute HIV-1 infection (AHI) included not only HIV-1–specific antibodies, but also influenza-specific and autoreactive antibodies, indicating very early onset of HIV-1–induced polyclonal B cell activation. Follicular damage or germinal center loss in terminal ileum Peyer's patches was seen with 88% of follicles exhibiting B or T cell apoptosis and follicular lysis.</p><h3>Conclusions</h3><p>Early induction of polyclonal B cell differentiation, coupled with follicular damage and germinal center loss soon after HIV-1 infection, may explain both the high rate of decline in HIV-1–induced antibody responses and the delay in plasma antibody responses to HIV-1.</p><h3></h3><p><em>Please see later in the article for Editors' Summary</em></p></div>", "links"=>[], "tags"=>["polyclonal", "differentiation", "gastrointestinal", "tract", "germinal", "centers", "earliest", "stages", "hiv-1"], "article_id"=>147121, "categories"=>["Immunology", "Medicine"], "users"=>["Marc C. Levesque", "M. Anthony Moody", "Kwan-Ki Hwang", "Dawn J. Marshall", "John F. Whitesides", "Joshua D. Amos", "Thaddeus C. Gurley", "Sallie Allgood", "Benjamin B. Haynes", "Nathan A. Vandergrift", "Steven Plonk", "Daniel C. Parker", "Myron S. Cohen", "Georgia D. Tomaras", "Paul A. Goepfert", "George M. Shaw", "Jörn E. Schmitz", "Joseph J. Eron", "Nicholas J. Shaheen", "Charles B. Hicks", "Hua-Xin Liao", "Martin Markowitz", "Garnett Kelsoe", "David M. Margolis", "Barton F. Haynes"], "doi"=>["https://dx.doi.org/10.1371/journal.pmed.1000107.s001", "https://dx.doi.org/10.1371/journal.pmed.1000107.s002", "https://dx.doi.org/10.1371/journal.pmed.1000107.s003", "https://dx.doi.org/10.1371/journal.pmed.1000107.s004", "https://dx.doi.org/10.1371/journal.pmed.1000107.s005", "https://dx.doi.org/10.1371/journal.pmed.1000107.s006", "https://dx.doi.org/10.1371/journal.pmed.1000107.s007", "https://dx.doi.org/10.1371/journal.pmed.1000107.s008"], "stats"=>{"downloads"=>12, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Polyclonal_B_Cell_Differentiation_and_Loss_of_Gastrointestinal_Tract_Germinal_Centers_in_the_Earliest_Stages_of_HIV_1_Infection/147121", "title"=>"Polyclonal B Cell Differentiation and Loss of Gastrointestinal Tract Germinal Centers in the Earliest Stages of HIV-1 Infection", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2009-07-07 01:58:41"}
  • {"files"=>["https://ndownloader.figshare.com/files/892446"], "description"=>"<p>(A and B) The same follicle with germinal center as in <a href=\"http://www.plosmedicine.org/article/info:doi/10.1371/journal.pmed.1000107#pmed-1000107-g003\" target=\"_blank\">Figures 3A–3D</a>; brown CD16<sup>+</sup> cells (A) and CD56<sup>+</sup> cells (B). These photomicrographs show normal accumulation of NK cells in subepithelial areas. (C and D) An apoptotic Peyer's patch area in patient 018-4 terminal ileum with brown CD16<sup>+</sup> cells (C), and CD56<sup>+</sup> cells (D). In all four panels arrows indicate positive cells (40×).</p>", "links"=>[], "tags"=>["nk", "cells", "apoptotic", "nonapoptotic", "areas", "ahi", "terminal", "ileum", "patches"], "article_id"=>562866, "categories"=>["Immunology", "Medicine"], "users"=>["Marc C. Levesque", "M. Anthony Moody", "Kwan-Ki Hwang", "Dawn J. Marshall", "John F. Whitesides", "Joshua D. Amos", "Thaddeus C. Gurley", "Sallie Allgood", "Benjamin B. Haynes", "Nathan A. Vandergrift", "Steven Plonk", "Daniel C. Parker", "Myron S. Cohen", "Georgia D. Tomaras", "Paul A. Goepfert", "George M. Shaw", "Jörn E. Schmitz", "Joseph J. Eron", "Nicholas J. Shaheen", "Charles B. Hicks", "Hua-Xin Liao", "Martin Markowitz", "Garnett Kelsoe", "David M. Margolis", "Barton F. Haynes"], "doi"=>"https://dx.doi.org/10.1371/journal.pmed.1000107.g005", "stats"=>{"downloads"=>0, "page_views"=>15, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Infiltration_of_NK_cells_in_apoptotic_and_nonapoptotic_areas_of_AHI_terminal_ileum_Peyer_s_patches_of_patient_018_4_/562866", "title"=>"Infiltration of NK cells in apoptotic and nonapoptotic areas of AHI terminal ileum Peyer's patches of patient 018-4.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2009-07-07 00:47:46"}
  • {"files"=>["https://ndownloader.figshare.com/files/892757"], "description"=>"<p>(A–B) Bars (A) and horizontal line (B) show mean values; error bars show standard error of the mean. (A) Quantitative image analysis of terminal ileum lamina propria immune cells in six uninfected participants, six AHI patients not on ART, and eight AHI patients on ART. CD3<sup>+</sup> T cells were elevated in AHI (*<i>p</i> = 0.008, <i>t</i>-test) as were CD8+ T cells (<sup>†</sup><i>p</i> = 0.003, <i>t</i>-test). (B) Lamina propria κ/λ ratio skewing (<i>p</i> = 0.016, <i>t</i>-test). (C–H) (100×) Lamina propria of patient 025-7, 105 d after transmission, on ART 63 d, with predominant IgA, κ plasma cell expansion (κ/λ ratio = 2.53). (C) IgM, (D) IgG, (E) IgA, (F) Hematoxylin and Eosin stain, (G) κ light chains, and (H) λ light chains.</p>", "links"=>[], "tags"=>["hiv-1", "terminal", "ileum"], "article_id"=>563187, "categories"=>["Immunology", "Medicine"], "users"=>["Marc C. Levesque", "M. Anthony Moody", "Kwan-Ki Hwang", "Dawn J. Marshall", "John F. Whitesides", "Joshua D. Amos", "Thaddeus C. Gurley", "Sallie Allgood", "Benjamin B. Haynes", "Nathan A. Vandergrift", "Steven Plonk", "Daniel C. Parker", "Myron S. Cohen", "Georgia D. Tomaras", "Paul A. Goepfert", "George M. Shaw", "Jörn E. Schmitz", "Joseph J. Eron", "Nicholas J. Shaheen", "Charles B. Hicks", "Hua-Xin Liao", "Martin Markowitz", "Garnett Kelsoe", "David M. Margolis", "Barton F. Haynes"], "doi"=>"https://dx.doi.org/10.1371/journal.pmed.1000107.g007", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Effect_of_HIV_1_on_Terminal_Ileum_Immune_Cells_/563187", "title"=>"Effect of HIV-1 on Terminal Ileum Immune Cells.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2009-07-07 00:53:07"}
  • {"files"=>["https://ndownloader.figshare.com/files/893077"], "description"=>"<p>Responses lower in AHI on ART group versus AHI not on ART group by unequal variance <i>t</i>-test (<sup>a</sup>IgG gp140, <i>p</i> = 0.047; <sup>b</sup>IgA gp41, <i>p</i> = 0.020; <sup>c</sup>IgA gp140, <i>p</i> = 0.020).</p><p>N/A, not applicable.</p>", "links"=>[], "tags"=>["antiretroviral", "ahi", "hiv-1", "antibody"], "article_id"=>563509, "categories"=>["Immunology", "Medicine"], "users"=>["Marc C. Levesque", "M. Anthony Moody", "Kwan-Ki Hwang", "Dawn J. Marshall", "John F. Whitesides", "Joshua D. Amos", "Thaddeus C. Gurley", "Sallie Allgood", "Benjamin B. Haynes", "Nathan A. Vandergrift", "Steven Plonk", "Daniel C. Parker", "Myron S. Cohen", "Georgia D. Tomaras", "Paul A. Goepfert", "George M. Shaw", "Jörn E. Schmitz", "Joseph J. Eron", "Nicholas J. Shaheen", "Charles B. Hicks", "Hua-Xin Liao", "Martin Markowitz", "Garnett Kelsoe", "David M. Margolis", "Barton F. Haynes"], "doi"=>"https://dx.doi.org/10.1371/journal.pmed.1000107.t007", "stats"=>{"downloads"=>0, "page_views"=>12, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Effect_of_antiretroviral_treatment_in_AHI_on_HIV_1_antibody_responses_/563509", "title"=>"Effect of antiretroviral treatment in AHI on HIV-1 antibody responses.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2009-07-07 00:58:29"}
  • {"files"=>["https://ndownloader.figshare.com/files/893152"], "description"=>"a<p>gp41 antibodies are higher for patients without germinal centers (<i>t</i> = 3.62, <i>p</i> = 0.005) by unequal variance <i>t</i>-test.</p><p>N/A, not applicable.</p>", "links"=>[], "tags"=>["responses", "hiv-1", "antibody", "proteins", "ahi", "germinal", "centers"], "article_id"=>563578, "categories"=>["Immunology", "Medicine"], "users"=>["Marc C. Levesque", "M. Anthony Moody", "Kwan-Ki Hwang", "Dawn J. Marshall", "John F. Whitesides", "Joshua D. Amos", "Thaddeus C. Gurley", "Sallie Allgood", "Benjamin B. Haynes", "Nathan A. Vandergrift", "Steven Plonk", "Daniel C. Parker", "Myron S. Cohen", "Georgia D. Tomaras", "Paul A. Goepfert", "George M. Shaw", "Jörn E. Schmitz", "Joseph J. Eron", "Nicholas J. Shaheen", "Charles B. Hicks", "Hua-Xin Liao", "Martin Markowitz", "Garnett Kelsoe", "David M. Margolis", "Barton F. Haynes"], "doi"=>"https://dx.doi.org/10.1371/journal.pmed.1000107.t006", "stats"=>{"downloads"=>0, "page_views"=>2, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Antibody_responses_to_HIV_1_proteins_Antibody_to_HIV_1_proteins_in_AHI_with_germinal_centers_versus_no_germinal_centers_/563578", "title"=>"Antibody responses to HIV-1 proteins: Antibody to HIV-1 proteins in AHI with germinal centers versus no germinal centers.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2009-07-07 00:59:38"}
  • {"files"=>["https://ndownloader.figshare.com/files/893219"], "description"=>"a<p>Patients 019-2, 023-3, 008-6, 010-1, 016-8, 018-4, 025-7, 016-2 from <a href=\"http://www.plosmedicine.org/article/info:doi/10.1371/journal.pmed.1000107#pmed-1000107-t001\" target=\"_blank\">Table 1</a>.</p>b<p>Plasma viral load and GALT viral load are calculated as geometric means.</p>c<p><i>p</i> = 0.021, exact Wilcoxon test, comparing patients with terminal ileum germinal centers versus those without terminal ileum germinal centers.</p>", "links"=>[], "tags"=>["ahi", "patients", "terminal", "ileum", "germinal", "centers"], "article_id"=>563644, "categories"=>["Immunology", "Medicine"], "users"=>["Marc C. Levesque", "M. Anthony Moody", "Kwan-Ki Hwang", "Dawn J. Marshall", "John F. Whitesides", "Joshua D. Amos", "Thaddeus C. Gurley", "Sallie Allgood", "Benjamin B. Haynes", "Nathan A. Vandergrift", "Steven Plonk", "Daniel C. Parker", "Myron S. Cohen", "Georgia D. Tomaras", "Paul A. Goepfert", "George M. Shaw", "Jörn E. Schmitz", "Joseph J. Eron", "Nicholas J. Shaheen", "Charles B. Hicks", "Hua-Xin Liao", "Martin Markowitz", "Garnett Kelsoe", "David M. Margolis", "Barton F. Haynes"], "doi"=>"https://dx.doi.org/10.1371/journal.pmed.1000107.t005", "stats"=>{"downloads"=>1, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Comparison_of_AHI_patients_with_terminal_ileum_germinal_centers_versus_those_without_terminal_ileum_germinal_centers_/563644", "title"=>"Comparison of AHI patients with terminal ileum germinal centers versus those without terminal ileum germinal centers.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2009-07-07 01:00:44"}
  • {"files"=>["https://ndownloader.figshare.com/files/892264"], "description"=>"<p>(A–F) Early follicular lysis in a primary follicle of patient 019-2, 47 d after transmission, not on ART; arrows in each photomicrograph show same mantle zone T cell area (A–P, 40×). (A) Hematoxylin and eosin stain. (B) CD20. (C) TUNEL stain with apoptosis in the mantle zone. (D) Rim of CD4<sup>+</sup> T cells in apoptotic mantle zone. (E) Infiltrating CD8<sup>+</sup> T cells. (F) Infiltrating CD11c<sup>+</sup> macrophages. (G–P) Serial sections of a small germinal center remnant in patient 023-3, 66 d after transmission, not on ART (plasma viral load 203 copies/ml, and the only participant in this study who spontaneously controlled plasma viremia). (G) Hematoxylin and eosin stain. (H) CD20<sup>+</sup> B cells. (I) TUNEL stain of apoptotic B cells surrounding a small germinal center. (J) Follicular CD4<sup>+</sup> depletion with weakly stained CD4<sup>+</sup> macrophages. (K) CD8<sup>+</sup> T cells in follicle areas around the germinal center. (L) CD68<sup>+</sup> tingible body macrophages in the germinal center (arrows). (M) Ki-67<sup>+</sup> dividing germinal center cells in serial sections with same area outlined in dotted line; (N) CD20<sup>+</sup> B cells in same area. (O) TUNEL-stained apoptotic cells surrounding the Ki-67<sup>+</sup>, nonapoptotic germinal center B cells. (P) CD11c<sup>+</sup> myeloid cells. (Q) Brown CD8<sup>+</sup> T cells in close apposition to apoptotic and fragmented cells (arrows) in patient 017-9, 56 d after transmission and not on ART (100×).</p>", "links"=>[], "tags"=>["apoptosis", "terminal", "ileal", "patches", "hiv-1"], "article_id"=>562686, "categories"=>["Immunology", "Medicine"], "users"=>["Marc C. Levesque", "M. Anthony Moody", "Kwan-Ki Hwang", "Dawn J. Marshall", "John F. Whitesides", "Joshua D. Amos", "Thaddeus C. Gurley", "Sallie Allgood", "Benjamin B. Haynes", "Nathan A. Vandergrift", "Steven Plonk", "Daniel C. Parker", "Myron S. Cohen", "Georgia D. Tomaras", "Paul A. Goepfert", "George M. Shaw", "Jörn E. Schmitz", "Joseph J. Eron", "Nicholas J. Shaheen", "Charles B. Hicks", "Hua-Xin Liao", "Martin Markowitz", "Garnett Kelsoe", "David M. Margolis", "Barton F. Haynes"], "doi"=>"https://dx.doi.org/10.1371/journal.pmed.1000107.g004", "stats"=>{"downloads"=>0, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Stages_of_B_cell_apoptosis_in_terminal_ileal_Peyer_s_patches_soon_after_HIV_1_transmission_/562686", "title"=>"Stages of B cell apoptosis in terminal ileal Peyer's patches soon after HIV-1 transmission.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2009-07-07 00:44:46"}

PMC Usage Stats | Further Information

  • {"month"=>"1", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"4", "full-text"=>"48", "year"=>"2010", "pdf"=>"27", "unique-ip"=>"53", "figure"=>"7", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"2", "cited-by"=>"0", "abstract"=>"4", "full-text"=>"62", "unique-ip"=>"28", "pdf"=>"5", "year"=>"2010", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"3", "scanned-page-browse"=>"0", "cited-by"=>"1", "abstract"=>"3", "full-text"=>"25", "year"=>"2010", "pdf"=>"39", "unique-ip"=>"33", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"9"}
  • {"scanned-page-browse"=>"0", "month"=>"4", "cited-by"=>"0", "abstract"=>"7", "full-text"=>"35", "unique-ip"=>"43", "pdf"=>"20", "year"=>"2010", "figure"=>"4", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"5", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"7", "full-text"=>"34", "year"=>"2010", "pdf"=>"25", "unique-ip"=>"37", "figure"=>"2", "scanned-summary"=>"0", "supp-data"=>"3"}
  • {"scanned-page-browse"=>"0", "month"=>"6", "cited-by"=>"0", "abstract"=>"6", "full-text"=>"28", "unique-ip"=>"33", "pdf"=>"22", "year"=>"2010", "figure"=>"2", "scanned-summary"=>"0", "supp-data"=>"13"}
  • {"month"=>"7", "scanned-page-browse"=>"0", "cited-by"=>"3", "abstract"=>"7", "full-text"=>"29", "year"=>"2010", "pdf"=>"12", "unique-ip"=>"21", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"8", "cited-by"=>"0", "abstract"=>"4", "full-text"=>"15", "unique-ip"=>"21", "pdf"=>"12", "year"=>"2010", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"9"}
  • {"month"=>"9", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"6", "full-text"=>"19", "year"=>"2010", "pdf"=>"36", "unique-ip"=>"27", "figure"=>"17", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"10", "cited-by"=>"0", "abstract"=>"2", "full-text"=>"21", "unique-ip"=>"30", "pdf"=>"25", "year"=>"2010", "figure"=>"1", "scanned-summary"=>"0", "supp-data"=>"1"}
  • {"month"=>"11", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"2", "full-text"=>"20", "year"=>"2010", "pdf"=>"20", "unique-ip"=>"30", "figure"=>"2", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"12", "cited-by"=>"0", "abstract"=>"2", "full-text"=>"17", "unique-ip"=>"24", "pdf"=>"20", "year"=>"2010", "figure"=>"4", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"1", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"2", "full-text"=>"15", "year"=>"2011", "pdf"=>"18", "unique-ip"=>"23", "figure"=>"1", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"2", "cited-by"=>"0", "abstract"=>"5", "full-text"=>"22", "unique-ip"=>"30", "pdf"=>"20", "year"=>"2011", "figure"=>"5", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"3", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"4", "full-text"=>"21", "year"=>"2011", "pdf"=>"20", "unique-ip"=>"31", "figure"=>"12", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"4", "cited-by"=>"0", "abstract"=>"7", "full-text"=>"14", "unique-ip"=>"22", "pdf"=>"11", "year"=>"2011", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"5", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"10", "full-text"=>"8", "year"=>"2011", "pdf"=>"10", "unique-ip"=>"17", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"6", "cited-by"=>"0", "abstract"=>"2", "full-text"=>"22", "unique-ip"=>"22", "pdf"=>"14", "year"=>"2011", "figure"=>"2", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"7", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"2", "full-text"=>"17", "year"=>"2011", "pdf"=>"8", "unique-ip"=>"19", "figure"=>"2", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"8", "cited-by"=>"1", "abstract"=>"1", "full-text"=>"20", "unique-ip"=>"22", "pdf"=>"11", "year"=>"2011", "figure"=>"1", "scanned-summary"=>"0", "supp-data"=>"1"}
  • {"month"=>"9", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"13", "year"=>"2011", "pdf"=>"6", "unique-ip"=>"15", "figure"=>"4", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"10", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"23", "unique-ip"=>"26", "pdf"=>"20", "year"=>"2011", "figure"=>"7", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"11", "scanned-page-browse"=>"0", "cited-by"=>"1", "abstract"=>"0", "full-text"=>"24", "year"=>"2011", "pdf"=>"13", "unique-ip"=>"22", "figure"=>"1", "scanned-summary"=>"0", "supp-data"=>"1"}
  • {"scanned-page-browse"=>"0", "month"=>"12", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"15", "unique-ip"=>"15", "pdf"=>"16", "year"=>"2011", "figure"=>"3", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"1", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"5", "unique-ip"=>"9", "pdf"=>"7", "year"=>"2012", "figure"=>"1", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"2", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"17", "year"=>"2012", "pdf"=>"8", "unique-ip"=>"19", "figure"=>"2", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"3", "cited-by"=>"1", "abstract"=>"0", "full-text"=>"17", "unique-ip"=>"19", "pdf"=>"8", "year"=>"2012", "figure"=>"1", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"4", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"2", "full-text"=>"12", "year"=>"2012", "pdf"=>"8", "unique-ip"=>"17", "figure"=>"6", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"5", "cited-by"=>"0", "abstract"=>"2", "full-text"=>"17", "unique-ip"=>"15", "pdf"=>"7", "year"=>"2012", "figure"=>"2", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"7", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"8", "full-text"=>"88", "year"=>"2009", "pdf"=>"83", "unique-ip"=>"85", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"8", "cited-by"=>"0", "abstract"=>"5", "full-text"=>"62", "unique-ip"=>"66", "pdf"=>"58", "year"=>"2009", "figure"=>"1", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"9", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"3", "full-text"=>"52", "year"=>"2009", "pdf"=>"58", "unique-ip"=>"59", "figure"=>"10", "scanned-summary"=>"0", "supp-data"=>"1"}
  • {"scanned-page-browse"=>"0", "month"=>"10", "cited-by"=>"0", "abstract"=>"2", "full-text"=>"19", "unique-ip"=>"19", "pdf"=>"10", "year"=>"2009", "figure"=>"5", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"11", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"10", "full-text"=>"48", "year"=>"2009", "pdf"=>"22", "unique-ip"=>"58", "figure"=>"5", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"12", "cited-by"=>"0", "abstract"=>"4", "full-text"=>"38", "unique-ip"=>"40", "pdf"=>"10", "year"=>"2009", "figure"=>"8", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"6", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"13", "year"=>"2012", "pdf"=>"48", "unique-ip"=>"12", "figure"=>"1", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"unique-ip"=>"5", "full-text"=>"5", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"7"}
  • {"unique-ip"=>"26", "full-text"=>"18", "pdf"=>"13", "abstract"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2012", "month"=>"8"}
  • {"unique-ip"=>"5", "full-text"=>"5", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2012", "month"=>"9"}
  • {"unique-ip"=>"10", "full-text"=>"9", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2012", "month"=>"10"}
  • {"unique-ip"=>"6", "full-text"=>"8", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"12"}
  • {"unique-ip"=>"8", "full-text"=>"10", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"1"}
  • {"unique-ip"=>"13", "full-text"=>"17", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"2"}
  • {"unique-ip"=>"12", "full-text"=>"10", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"3"}
  • {"unique-ip"=>"11", "full-text"=>"12", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"4"}
  • {"unique-ip"=>"10", "full-text"=>"7", "pdf"=>"7", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"11"}
  • {"unique-ip"=>"9", "full-text"=>"8", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"5"}
  • {"unique-ip"=>"11", "full-text"=>"8", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"6"}
  • {"unique-ip"=>"5", "full-text"=>"5", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"7"}
  • {"unique-ip"=>"8", "full-text"=>"7", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"9", "cited-by"=>"0", "year"=>"2013", "month"=>"8"}
  • {"unique-ip"=>"10", "full-text"=>"10", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"9"}
  • {"unique-ip"=>"2", "full-text"=>"2", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"10"}
  • {"unique-ip"=>"16", "full-text"=>"21", "pdf"=>"11", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"11", "supp-data"=>"7", "cited-by"=>"0", "year"=>"2013", "month"=>"11"}
  • {"unique-ip"=>"12", "full-text"=>"12", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"2", "year"=>"2013", "month"=>"12"}
  • {"unique-ip"=>"4", "full-text"=>"2", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"1"}
  • {"unique-ip"=>"5", "full-text"=>"5", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"2"}
  • {"unique-ip"=>"10", "full-text"=>"8", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"3"}
  • {"unique-ip"=>"8", "full-text"=>"6", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"5"}
  • {"unique-ip"=>"8", "full-text"=>"6", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"6"}
  • {"unique-ip"=>"11", "full-text"=>"15", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"4"}
  • {"unique-ip"=>"23", "full-text"=>"27", "pdf"=>"3", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"11", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"7"}
  • {"unique-ip"=>"20", "full-text"=>"20", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2014", "month"=>"8"}
  • {"unique-ip"=>"22", "full-text"=>"24", "pdf"=>"3", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"9"}
  • {"unique-ip"=>"14", "full-text"=>"15", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"10"}
  • {"unique-ip"=>"22", "full-text"=>"32", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"11"}
  • {"unique-ip"=>"10", "full-text"=>"15", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"12"}
  • {"unique-ip"=>"10", "full-text"=>"10", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2015", "month"=>"1"}
  • {"unique-ip"=>"6", "full-text"=>"6", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"2"}
  • {"unique-ip"=>"10", "full-text"=>"15", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"3"}
  • {"unique-ip"=>"15", "full-text"=>"11", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"12", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"4"}
  • {"unique-ip"=>"8", "full-text"=>"7", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"5"}
  • {"unique-ip"=>"9", "full-text"=>"8", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"6"}
  • {"unique-ip"=>"11", "full-text"=>"12", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"7"}
  • {"unique-ip"=>"11", "full-text"=>"5", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2015", "month"=>"8"}
  • {"unique-ip"=>"9", "full-text"=>"9", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"9"}
  • {"unique-ip"=>"8", "full-text"=>"7", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"10"}
  • {"unique-ip"=>"32", "full-text"=>"11", "pdf"=>"30", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"3", "year"=>"2015", "month"=>"11"}
  • {"unique-ip"=>"13", "full-text"=>"10", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"12"}
  • {"unique-ip"=>"10", "full-text"=>"10", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"1"}
  • {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"2"}
  • {"unique-ip"=>"3", "full-text"=>"1", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"3"}
  • {"unique-ip"=>"7", "full-text"=>"6", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"4"}
  • {"unique-ip"=>"12", "full-text"=>"10", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"5"}
  • {"unique-ip"=>"6", "full-text"=>"6", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"6"}
  • {"unique-ip"=>"7", "full-text"=>"6", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"7"}
  • {"unique-ip"=>"10", "full-text"=>"10", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2016", "month"=>"8"}
  • {"unique-ip"=>"7", "full-text"=>"5", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"9"}
  • {"unique-ip"=>"10", "full-text"=>"11", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"10"}
  • {"unique-ip"=>"5", "full-text"=>"5", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"11"}
  • {"unique-ip"=>"7", "full-text"=>"6", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"12"}
  • {"unique-ip"=>"15", "full-text"=>"8", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"1"}
  • {"unique-ip"=>"6", "full-text"=>"7", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"2"}
  • {"unique-ip"=>"4", "full-text"=>"3", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"3"}
  • {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"4"}
  • {"unique-ip"=>"9", "full-text"=>"12", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"5"}
  • {"unique-ip"=>"6", "full-text"=>"6", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"6"}
  • {"unique-ip"=>"2", "full-text"=>"2", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"7"}
  • {"unique-ip"=>"8", "full-text"=>"9", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"8"}
  • {"unique-ip"=>"3", "full-text"=>"9", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"6", "cited-by"=>"0", "year"=>"2017", "month"=>"9"}
  • {"unique-ip"=>"14", "full-text"=>"28", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"10"}
  • {"unique-ip"=>"12", "full-text"=>"21", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"11"}
  • {"unique-ip"=>"3", "full-text"=>"11", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"12"}
  • {"unique-ip"=>"4", "full-text"=>"16", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2018", "month"=>"1"}
  • {"unique-ip"=>"10", "full-text"=>"8", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"3"}
  • {"unique-ip"=>"8", "full-text"=>"8", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"1"}
  • {"unique-ip"=>"10", "full-text"=>"7", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"5"}
  • {"unique-ip"=>"10", "full-text"=>"9", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"4"}
  • {"unique-ip"=>"11", "full-text"=>"10", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"6"}
  • {"unique-ip"=>"10", "full-text"=>"6", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2018", "month"=>"7"}
  • {"unique-ip"=>"15", "full-text"=>"16", "pdf"=>"6", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"8"}
  • {"unique-ip"=>"7", "full-text"=>"5", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"9"}
  • {"unique-ip"=>"5", "full-text"=>"4", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"10"}
  • {"unique-ip"=>"6", "full-text"=>"6", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"4", "cited-by"=>"0", "year"=>"2018", "month"=>"11"}
  • {"unique-ip"=>"8", "full-text"=>"7", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"12"}
  • {"unique-ip"=>"4", "full-text"=>"6", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"2"}
  • {"unique-ip"=>"11", "full-text"=>"10", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"3"}
  • {"unique-ip"=>"10", "full-text"=>"8", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"10", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2019", "month"=>"4"}
  • {"unique-ip"=>"12", "full-text"=>"14", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"5"}

Relative Metric

{"start_date"=>"2009-01-01T00:00:00Z", "end_date"=>"2009-12-31T00:00:00Z", "subject_areas"=>[{"subject_area"=>"/Biology and life sciences", "average_usage"=>[349, 614, 744, 851, 955, 1059, 1167, 1262, 1352, 1431, 1516, 1593, 1668, 1746, 1817, 1883, 1950, 2017, 2075, 2141, 2198, 2254, 2313, 2368, 2424, 2474, 2534, 2591, 2651, 2710, 2776, 2837, 2892, 2953, 3014, 3072, 3130, 3186, 3251, 3307, 3366, 3427, 3500, 3561, 3627, 3688, 3759, 3821, 3888, 3950, 4010, 4070, 4131, 4189, 4242, 4307, 4370, 4431, 4491, 4549, 4608]}, {"subject_area"=>"/Biology and life sciences/Anatomy", "average_usage"=>[342, 579, 717, 815, 916, 1016, 1128, 1233, 1326, 1409, 1498, 1583, 1649, 1726, 1805, 1871, 1941, 2005, 2074, 2130, 2182, 2233, 2290, 2334, 2405, 2443, 2493, 2539, 2605, 2666, 2714, 2773, 2834, 2886, 2961, 3012, 3075, 3126, 3185, 3258, 3314, 3381, 3458, 3519, 3587, 3633, 3709, 3756, 3830, 3880, 3943, 4014, 4062, 4131, 4184, 4235, 4288, 4331, 4398, 4440, 4505]}, {"subject_area"=>"/Biology and life sciences/Anatomy and physiology", "average_usage"=>[320, 564, 690, 796, 901, 1003, 1105, 1196, 1286, 1367, 1453, 1523, 1601, 1673, 1743, 1807, 1879, 1931, 1993, 2053, 2108, 2165, 2218, 2273, 2327, 2375, 2432, 2492, 2539, 2590, 2639, 2694, 2742, 2807, 2861, 2918, 2977, 3032, 3086, 3145, 3204, 3260, 3326, 3378, 3438, 3496, 3558, 3626]}, {"subject_area"=>"/Biology and life sciences/Cell biology", "average_usage"=>[336, 588, 721, 826, 931, 1029, 1138, 1224, 1311, 1395, 1477, 1555, 1632, 1704, 1774, 1847, 1919, 1987, 2039, 2089, 2149, 2204, 2264, 2319, 2370, 2424, 2481, 2535, 2593, 2645, 2702, 2765, 2816, 2865, 2932, 2992, 3045, 3105, 3159, 3208, 3259, 3316, 3374, 3430, 3490, 3542, 3602, 3654, 3720, 3783, 3851, 3919, 3981, 4038, 4096, 4151, 4197, 4235, 4297, 4372, 4437]}, {"subject_area"=>"/Biology and life sciences/Immunology", "average_usage"=>[302, 541, 669, 778, 878, 978, 1080, 1163, 1254, 1345, 1432, 1510, 1575, 1651, 1711, 1789, 1861, 1916, 1961, 2020, 2083, 2135, 2199, 2233, 2281, 2332, 2387, 2432, 2481, 2540, 2583, 2626, 2680, 2718, 2759, 2810, 2868, 2918, 2962, 3007, 3062, 3113, 3174, 3252, 3315, 3356, 3401, 3468, 3520, 3557, 3617, 3674, 3728, 3781, 3824, 3873, 3929, 3981, 4041, 4088, 4138]}, {"subject_area"=>"/Biology and life sciences/Organisms", "average_usage"=>[337, 605, 735, 844, 939, 1037, 1139, 1214, 1300, 1375, 1461, 1543, 1619, 1693, 1768, 1827, 1881, 1948, 2013, 2066, 2118, 2172, 2227, 2270, 2325, 2386, 2443, 2504, 2565, 2609, 2659, 2731, 2792, 2857, 2920, 2984, 3051, 3101, 3165, 3213, 3276, 3344, 3397, 3462, 3512, 3561, 3629, 3710, 3779, 3847, 3897, 3949, 4013, 4086, 4140, 4180, 4239, 4288, 4344, 4409, 4470]}, {"subject_area"=>"/Biology and life sciences/Physiology", "average_usage"=>[306, 556, 687, 796, 910, 1010, 1116, 1207, 1291, 1370, 1458, 1539, 1613, 1694, 1768, 1842, 1905, 1965, 2034, 2097, 2148, 2198, 2253, 2307, 2349, 2409, 2462, 2516, 2562, 2614, 2666, 2723, 2779, 2833, 2895, 2961, 3009, 3061, 3119, 3183, 3232, 3303, 3367, 3414, 3464, 3516, 3588, 3648, 3713, 3774, 3827, 3880, 3953, 4012, 4070, 4125, 4187, 4230, 4291, 4339, 4393]}, {"subject_area"=>"/Medicine and health sciences", "average_usage"=>[332, 584, 719, 824, 927, 1030, 1139, 1233, 1322, 1402, 1483, 1570, 1649, 1730, 1806, 1873, 1939, 2003, 2068, 2130, 2191, 2248, 2302, 2362, 2427, 2485, 2544, 2599, 2653, 2709, 2778, 2840, 2896, 2950, 3013, 3073, 3137, 3189, 3253, 3305, 3364, 3423, 3489, 3557, 3606, 3668, 3742, 3797, 3852, 3907, 3962, 4027, 4072, 4132, 4193, 4256, 4308, 4366, 4427, 4493, 4556]}, {"subject_area"=>"/Medicine and health sciences/Immunology", "average_usage"=>[306, 552, 683, 801, 902, 1004, 1103, 1192, 1279, 1350, 1434, 1503, 1564, 1641, 1705, 1779, 1833, 1887, 1946, 2001, 2054, 2105, 2167, 2218, 2270, 2307, 2358, 2410, 2454, 2504, 2560, 2608, 2656, 2713, 2757, 2807, 2856, 2912, 2959, 3010, 3059, 3111, 3162, 3216, 3282, 3336, 3393, 3453, 3512, 3569, 3623, 3687, 3746, 3792, 3838, 3888, 3938, 3997, 4059, 4114, 4152]}, {"subject_area"=>"/Medicine and health sciences/Pathology and laboratory medicine", "average_usage"=>[302, 565, 710, 814, 921, 1026, 1126, 1222, 1311, 1409, 1491, 1580, 1659, 1736, 1809, 1874, 1947, 2004, 2061, 2133, 2186, 2236, 2302, 2362, 2441, 2494, 2550, 2603, 2651, 2711, 2785, 2840, 2904, 2962, 3018, 3066, 3133, 3181, 3253, 3300, 3357, 3409, 3459, 3556, 3621, 3657, 3709, 3784, 3856, 3886, 3958, 4027, 4081, 4124, 4183, 4241, 4297, 4338, 4391, 4437, 4488]}, {"subject_area"=>"/Medicine and health sciences/Physiology", "average_usage"=>[321, 578, 720, 834, 929, 1032, 1139, 1230, 1314, 1399, 1483, 1569, 1645, 1719, 1793, 1864, 1941, 2002, 2063, 2129, 2189, 2232, 2285, 2336, 2395, 2448, 2515, 2581, 2637, 2681, 2747, 2800, 2854, 2920, 2974, 3039, 3088, 3143, 3202, 3258, 3299, 3389, 3447, 3510, 3573, 3643, 3713, 3771, 3845, 3907, 3956, 4020, 4074, 4127, 4187, 4251, 4316, 4354, 4401, 4472, 4518]}]}
Loading … Spinner
There are currently no alerts