The Preclinical Natural History of Serous Ovarian Cancer: Defining the Target for Early Detection
Events
Loading … Spinner

CiteULike | Further Information

Mendeley | Further Information

{"title"=>"The preclinical natural history of serous ovarian cancer: Defining the target for early detection", "type"=>"journal", "authors"=>[{"first_name"=>"Patrick O.", "last_name"=>"Brown", "scopus_author_id"=>"35414776900"}, {"first_name"=>"Chana", "last_name"=>"Palmer", "scopus_author_id"=>"12040165700"}], "year"=>2009, "source"=>"PLoS Medicine", "identifiers"=>{"scopus"=>"2-s2.0-68049122014", "sgr"=>"68049122014", "issn"=>"15491277", "isbn"=>"10.1371/journal.pmed.1000114", "pmid"=>"19636370", "doi"=>"10.1371/journal.pmed.1000114", "pui"=>"355033312"}, "id"=>"1f427d6c-ef72-3f68-90cf-d108c088527a", "abstract"=>"BACKGROUND: Ovarian cancer kills approximately 15,000 women in the United States every year, and more than 140,000 women worldwide. Most deaths from ovarian cancer are caused by tumors of the serous histological type, which are rarely diagnosed before the cancer has spread. Rational design of a potentially life-saving early detection and intervention strategy requires understanding the lesions we must detect in order to prevent lethal progression. Little is known about the natural history of lethal serous ovarian cancers before they become clinically apparent. We can learn about this occult period by studying the unsuspected serous cancers that are discovered in a small fraction of apparently healthy women who undergo prophylactic bilateral salpingo-oophorectomy (PBSO). METHODS AND FINDINGS: We developed models for the growth, progression, and detection of occult serous cancers on the basis of a comprehensive analysis of published data on serous cancers discovered by PBSO in BRCA1 mutation carriers. Our analysis yielded several critical insights into the early natural history of serous ovarian cancer. First, these cancers spend on average more than 4 y as in situ, stage I, or stage II cancers and approximately 1 y as stage III or IV cancers before they become clinically apparent. Second, for most of the occult period, serous cancers are less than 1 cm in diameter, and not visible on gross examination of the ovaries and Fallopian tubes. Third, the median diameter of a serous ovarian cancer when it progresses to an advanced stage (stage III or IV) is about 3 cm. Fourth, to achieve 50% sensitivity in detecting tumors before they advance to stage III, an annual screen would need to detect tumors of 1.3 cm in diameter; 80% detection sensitivity would require detecting tumors less than 0.4 cm in diameter. Fifth, to achieve a 50% reduction in serous ovarian cancer mortality with an annual screen, a test would need to detect tumors of 0.5 cm in diameter. CONCLUSIONS: Our analysis has formalized essential conditions for successful early detection of serous ovarian cancer. Although the window of opportunity for early detection of these cancers lasts for several years, developing a test sufficiently sensitive and specific to take advantage of that opportunity will be a challenge. We estimated that the tumors we would need to detect to achieve even 50% sensitivity are more than 200 times smaller than the clinically apparent serous cancers typically used to evaluate performance of candidate biomarkers; none of the biomarker assays reported to date comes close to the required level of performance. Overcoming the signal-to-noise problem inherent in detection of tiny tumors will likely require discovery of truly cancer-specific biomarkers or development of novel approaches beyond traditional blood protein biomarkers. While this study was limited to ovarian cancers of serous histological type and to those arising in BRCA1 mutation carriers specifically, we believe that the results are relevant to other hereditary serous cancers and to sporadic ovarian cancers. A similar approach could be applied to other cancers to aid in defining their early natural history and to guide rational design of an early detection strategy.", "link"=>"http://www.mendeley.com/research/preclinical-natural-history-serous-ovarian-cancer-defining-target-early-detection", "reader_count"=>84, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Professor > Associate Professor"=>2, "Librarian"=>1, "Student > Doctoral Student"=>2, "Researcher"=>26, "Student > Ph. D. Student"=>22, "Student > Postgraduate"=>5, "Student > Master"=>5, "Other"=>9, "Student > Bachelor"=>6, "Lecturer"=>2, "Professor"=>3}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Professor > Associate Professor"=>2, "Librarian"=>1, "Student > Doctoral Student"=>2, "Researcher"=>26, "Student > Ph. D. Student"=>22, "Student > Postgraduate"=>5, "Student > Master"=>5, "Other"=>9, "Student > Bachelor"=>6, "Lecturer"=>2, "Professor"=>3}, "reader_count_by_subject_area"=>{"Unspecified"=>2, "Agricultural and Biological Sciences"=>22, "Business, Management and Accounting"=>3, "Chemistry"=>2, "Computer Science"=>1, "Economics, Econometrics and Finance"=>1, "Engineering"=>3, "Biochemistry, Genetics and Molecular Biology"=>7, "Nursing and Health Professions"=>1, "Materials Science"=>1, "Mathematics"=>2, "Medicine and Dentistry"=>34, "Sports and Recreations"=>1, "Physics and Astronomy"=>1, "Psychology"=>1, "Social Sciences"=>2}, "reader_count_by_subdiscipline"=>{"Materials Science"=>{"Materials Science"=>1}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>34}, "Social Sciences"=>{"Social Sciences"=>2}, "Sports and Recreations"=>{"Sports and Recreations"=>1}, "Physics and Astronomy"=>{"Physics and Astronomy"=>1}, "Psychology"=>{"Psychology"=>1}, "Mathematics"=>{"Mathematics"=>2}, "Unspecified"=>{"Unspecified"=>2}, "Engineering"=>{"Engineering"=>3}, "Chemistry"=>{"Chemistry"=>2}, "Economics, Econometrics and Finance"=>{"Economics, Econometrics and Finance"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>22}, "Computer Science"=>{"Computer Science"=>1}, "Business, Management and Accounting"=>{"Business, Management and Accounting"=>3}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>7}}, "reader_count_by_country"=>{"Netherlands"=>1, "United States"=>1, "Brazil"=>2, "United Kingdom"=>2, "Nigeria"=>1}, "group_count"=>10}

CrossRef

Scopus | Further Information

{"@_fa"=>"true", "link"=>[{"@_fa"=>"true", "@ref"=>"self", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/68049122014"}, {"@_fa"=>"true", "@ref"=>"author-affiliation", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/68049122014?field=author,affiliation"}, {"@_fa"=>"true", "@ref"=>"scopus", "@href"=>"https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=68049122014&origin=inward"}, {"@_fa"=>"true", "@ref"=>"scopus-citedby", "@href"=>"https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=68049122014&origin=inward"}], "prism:url"=>"https://api.elsevier.com/content/abstract/scopus_id/68049122014", "dc:identifier"=>"SCOPUS_ID:68049122014", "eid"=>"2-s2.0-68049122014", "dc:title"=>"The preclinical natural history of serous ovarian cancer: Defining the target for early detection", "dc:creator"=>"Brown P.", "prism:publicationName"=>"PLoS Medicine", "prism:issn"=>"15491277", "prism:eIssn"=>"15491676", "prism:volume"=>"6", "prism:issueIdentifier"=>"7", "prism:pageRange"=>nil, "prism:coverDate"=>"2009-07-01", "prism:coverDisplayDate"=>"July 2009", "prism:doi"=>"10.1371/journal.pmed.1000114", "citedby-count"=>"174", "affiliation"=>[{"@_fa"=>"true", "affilname"=>"Stanford University School of Medicine", "affiliation-city"=>"Stanford", "affiliation-country"=>"United States"}, {"@_fa"=>"true", "affilname"=>"Howard Hughes Medical Institute", "affiliation-city"=>"Chevy Chase", "affiliation-country"=>"United States"}], "pubmed-id"=>"19636370", "prism:aggregationType"=>"Journal", "subtype"=>"ar", "subtypeDescription"=>"Article", "article-number"=>"e1000114", "source-id"=>"144840", "openaccess"=>"1", "openaccessFlag"=>true}

Facebook

  • {"url"=>"http%3A%2F%2Fjournals.plos.org%2Fplosmedicine%2Farticle%3Fid%3D10.1371%252Fjournal.pmed.1000114", "share_count"=>0, "like_count"=>0, "comment_count"=>0, "click_count"=>0, "total_count"=>0}

Journal Comments | Further Information

Counter

  • {"month"=>"7", "year"=>"2009", "pdf_views"=>"218", "xml_views"=>"5", "html_views"=>"986"}
  • {"month"=>"8", "year"=>"2009", "pdf_views"=>"255", "xml_views"=>"14", "html_views"=>"1042"}
  • {"month"=>"9", "year"=>"2009", "pdf_views"=>"47", "xml_views"=>"1", "html_views"=>"252"}
  • {"month"=>"10", "year"=>"2009", "pdf_views"=>"27", "xml_views"=>"0", "html_views"=>"193"}
  • {"month"=>"11", "year"=>"2009", "pdf_views"=>"18", "xml_views"=>"1", "html_views"=>"151"}
  • {"month"=>"12", "year"=>"2009", "pdf_views"=>"21", "xml_views"=>"1", "html_views"=>"135"}
  • {"month"=>"1", "year"=>"2010", "pdf_views"=>"25", "xml_views"=>"1", "html_views"=>"157"}
  • {"month"=>"2", "year"=>"2010", "pdf_views"=>"21", "xml_views"=>"1", "html_views"=>"163"}
  • {"month"=>"3", "year"=>"2010", "pdf_views"=>"35", "xml_views"=>"1", "html_views"=>"227"}
  • {"month"=>"4", "year"=>"2010", "pdf_views"=>"9", "xml_views"=>"2", "html_views"=>"155"}
  • {"month"=>"5", "year"=>"2010", "pdf_views"=>"20", "xml_views"=>"0", "html_views"=>"139"}
  • {"month"=>"6", "year"=>"2010", "pdf_views"=>"14", "xml_views"=>"0", "html_views"=>"98"}
  • {"month"=>"7", "year"=>"2010", "pdf_views"=>"17", "xml_views"=>"0", "html_views"=>"97"}
  • {"month"=>"8", "year"=>"2010", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"105"}
  • {"month"=>"9", "year"=>"2010", "pdf_views"=>"25", "xml_views"=>"1", "html_views"=>"131"}
  • {"month"=>"10", "year"=>"2010", "pdf_views"=>"21", "xml_views"=>"1", "html_views"=>"178"}
  • {"month"=>"11", "year"=>"2010", "pdf_views"=>"21", "xml_views"=>"0", "html_views"=>"131"}
  • {"month"=>"12", "year"=>"2010", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"87"}
  • {"month"=>"1", "year"=>"2011", "pdf_views"=>"13", "xml_views"=>"2", "html_views"=>"95"}
  • {"month"=>"2", "year"=>"2011", "pdf_views"=>"17", "xml_views"=>"0", "html_views"=>"128"}
  • {"month"=>"3", "year"=>"2011", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"139"}
  • {"month"=>"4", "year"=>"2011", "pdf_views"=>"16", "xml_views"=>"0", "html_views"=>"126"}
  • {"month"=>"5", "year"=>"2011", "pdf_views"=>"21", "xml_views"=>"1", "html_views"=>"67"}
  • {"month"=>"6", "year"=>"2011", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"71"}
  • {"month"=>"7", "year"=>"2011", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"77"}
  • {"month"=>"8", "year"=>"2011", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"89"}
  • {"month"=>"9", "year"=>"2011", "pdf_views"=>"19", "xml_views"=>"1", "html_views"=>"111"}
  • {"month"=>"10", "year"=>"2011", "pdf_views"=>"24", "xml_views"=>"1", "html_views"=>"168"}
  • {"month"=>"11", "year"=>"2011", "pdf_views"=>"23", "xml_views"=>"0", "html_views"=>"194"}
  • {"month"=>"12", "year"=>"2011", "pdf_views"=>"16", "xml_views"=>"0", "html_views"=>"153"}
  • {"month"=>"1", "year"=>"2012", "pdf_views"=>"10", "xml_views"=>"1", "html_views"=>"179"}
  • {"month"=>"2", "year"=>"2012", "pdf_views"=>"14", "xml_views"=>"0", "html_views"=>"138"}
  • {"month"=>"3", "year"=>"2012", "pdf_views"=>"17", "xml_views"=>"2", "html_views"=>"200"}
  • {"month"=>"4", "year"=>"2012", "pdf_views"=>"24", "xml_views"=>"1", "html_views"=>"221"}
  • {"month"=>"5", "year"=>"2012", "pdf_views"=>"22", "xml_views"=>"1", "html_views"=>"196"}
  • {"month"=>"6", "year"=>"2012", "pdf_views"=>"16", "xml_views"=>"1", "html_views"=>"121"}
  • {"month"=>"7", "year"=>"2012", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"146"}
  • {"month"=>"8", "year"=>"2012", "pdf_views"=>"19", "xml_views"=>"6", "html_views"=>"151"}
  • {"month"=>"9", "year"=>"2012", "pdf_views"=>"14", "xml_views"=>"0", "html_views"=>"158"}
  • {"month"=>"10", "year"=>"2012", "pdf_views"=>"17", "xml_views"=>"1", "html_views"=>"196"}
  • {"month"=>"11", "year"=>"2012", "pdf_views"=>"26", "xml_views"=>"0", "html_views"=>"215"}
  • {"month"=>"12", "year"=>"2012", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"176"}
  • {"month"=>"1", "year"=>"2013", "pdf_views"=>"18", "xml_views"=>"0", "html_views"=>"281"}
  • {"month"=>"2", "year"=>"2013", "pdf_views"=>"13", "xml_views"=>"2", "html_views"=>"305"}
  • {"month"=>"3", "year"=>"2013", "pdf_views"=>"20", "xml_views"=>"1", "html_views"=>"364"}
  • {"month"=>"4", "year"=>"2013", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"351"}
  • {"month"=>"5", "year"=>"2013", "pdf_views"=>"19", "xml_views"=>"0", "html_views"=>"370"}
  • {"month"=>"6", "year"=>"2013", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"190"}
  • {"month"=>"7", "year"=>"2013", "pdf_views"=>"8", "xml_views"=>"2", "html_views"=>"307"}
  • {"month"=>"8", "year"=>"2013", "pdf_views"=>"6", "xml_views"=>"2", "html_views"=>"198"}
  • {"month"=>"9", "year"=>"2013", "pdf_views"=>"17", "xml_views"=>"2", "html_views"=>"227"}
  • {"month"=>"10", "year"=>"2013", "pdf_views"=>"16", "xml_views"=>"1", "html_views"=>"220"}
  • {"month"=>"11", "year"=>"2013", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"239"}
  • {"month"=>"12", "year"=>"2013", "pdf_views"=>"17", "xml_views"=>"1", "html_views"=>"284"}
  • {"month"=>"1", "year"=>"2014", "pdf_views"=>"21", "xml_views"=>"0", "html_views"=>"268"}
  • {"month"=>"2", "year"=>"2014", "pdf_views"=>"21", "xml_views"=>"0", "html_views"=>"233"}
  • {"month"=>"3", "year"=>"2014", "pdf_views"=>"22", "xml_views"=>"2", "html_views"=>"357"}
  • {"month"=>"4", "year"=>"2014", "pdf_views"=>"24", "xml_views"=>"1", "html_views"=>"299"}
  • {"month"=>"5", "year"=>"2014", "pdf_views"=>"24", "xml_views"=>"1", "html_views"=>"276"}
  • {"month"=>"6", "year"=>"2014", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"226"}
  • {"month"=>"7", "year"=>"2014", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"180"}
  • {"month"=>"8", "year"=>"2014", "pdf_views"=>"7", "xml_views"=>"3", "html_views"=>"221"}
  • {"month"=>"9", "year"=>"2014", "pdf_views"=>"16", "xml_views"=>"2", "html_views"=>"192"}
  • {"month"=>"10", "year"=>"2014", "pdf_views"=>"10", "xml_views"=>"3", "html_views"=>"225"}
  • {"month"=>"11", "year"=>"2014", "pdf_views"=>"9", "xml_views"=>"1", "html_views"=>"208"}
  • {"month"=>"12", "year"=>"2014", "pdf_views"=>"10", "xml_views"=>"2", "html_views"=>"181"}
  • {"month"=>"1", "year"=>"2015", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"143"}
  • {"month"=>"2", "year"=>"2015", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"83"}
  • {"month"=>"3", "year"=>"2015", "pdf_views"=>"17", "xml_views"=>"0", "html_views"=>"115"}
  • {"month"=>"4", "year"=>"2015", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"78"}
  • {"month"=>"5", "year"=>"2015", "pdf_views"=>"13", "xml_views"=>"1", "html_views"=>"122"}
  • {"month"=>"6", "year"=>"2015", "pdf_views"=>"17", "xml_views"=>"0", "html_views"=>"80"}
  • {"month"=>"7", "year"=>"2015", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"79"}
  • {"month"=>"8", "year"=>"2015", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"72"}
  • {"month"=>"9", "year"=>"2015", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"107"}
  • {"month"=>"10", "year"=>"2015", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"105"}
  • {"month"=>"11", "year"=>"2015", "pdf_views"=>"11", "xml_views"=>"1", "html_views"=>"94"}
  • {"month"=>"12", "year"=>"2015", "pdf_views"=>"15", "xml_views"=>"0", "html_views"=>"90"}
  • {"month"=>"1", "year"=>"2016", "pdf_views"=>"35", "xml_views"=>"0", "html_views"=>"90"}
  • {"month"=>"2", "year"=>"2016", "pdf_views"=>"16", "xml_views"=>"0", "html_views"=>"82"}
  • {"month"=>"3", "year"=>"2016", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"105"}
  • {"month"=>"4", "year"=>"2016", "pdf_views"=>"15", "xml_views"=>"0", "html_views"=>"104"}
  • {"month"=>"5", "year"=>"2016", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"88"}
  • {"month"=>"6", "year"=>"2016", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"75"}
  • {"month"=>"7", "year"=>"2016", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"60"}
  • {"month"=>"8", "year"=>"2016", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"67"}
  • {"month"=>"9", "year"=>"2016", "pdf_views"=>"20", "xml_views"=>"0", "html_views"=>"118"}
  • {"month"=>"10", "year"=>"2016", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"151"}
  • {"month"=>"11", "year"=>"2016", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"133"}
  • {"month"=>"12", "year"=>"2016", "pdf_views"=>"11", "xml_views"=>"1", "html_views"=>"81"}
  • {"month"=>"1", "year"=>"2017", "pdf_views"=>"14", "xml_views"=>"0", "html_views"=>"87"}
  • {"month"=>"2", "year"=>"2017", "pdf_views"=>"15", "xml_views"=>"1", "html_views"=>"105"}
  • {"month"=>"3", "year"=>"2017", "pdf_views"=>"16", "xml_views"=>"4", "html_views"=>"138"}
  • {"month"=>"4", "year"=>"2017", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"136"}
  • {"month"=>"5", "year"=>"2017", "pdf_views"=>"12", "xml_views"=>"1", "html_views"=>"82"}
  • {"month"=>"6", "year"=>"2017", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"66"}
  • {"month"=>"7", "year"=>"2017", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"55"}
  • {"month"=>"8", "year"=>"2017", "pdf_views"=>"5", "xml_views"=>"1", "html_views"=>"51"}
  • {"month"=>"9", "year"=>"2017", "pdf_views"=>"33", "xml_views"=>"4", "html_views"=>"134"}
  • {"month"=>"10", "year"=>"2017", "pdf_views"=>"30", "xml_views"=>"3", "html_views"=>"173"}
  • {"month"=>"11", "year"=>"2017", "pdf_views"=>"25", "xml_views"=>"1", "html_views"=>"95"}
  • {"month"=>"12", "year"=>"2017", "pdf_views"=>"15", "xml_views"=>"0", "html_views"=>"82"}
  • {"month"=>"1", "year"=>"2018", "pdf_views"=>"38", "xml_views"=>"2", "html_views"=>"86"}
  • {"month"=>"2", "year"=>"2018", "pdf_views"=>"31", "xml_views"=>"0", "html_views"=>"48"}
  • {"month"=>"3", "year"=>"2018", "pdf_views"=>"12", "xml_views"=>"1", "html_views"=>"38"}
  • {"month"=>"4", "year"=>"2018", "pdf_views"=>"12", "xml_views"=>"1", "html_views"=>"41"}
  • {"month"=>"5", "year"=>"2018", "pdf_views"=>"8", "xml_views"=>"1", "html_views"=>"29"}
  • {"month"=>"6", "year"=>"2018", "pdf_views"=>"10", "xml_views"=>"5", "html_views"=>"23"}
  • {"month"=>"7", "year"=>"2018", "pdf_views"=>"19", "xml_views"=>"4", "html_views"=>"507"}
  • {"month"=>"8", "year"=>"2018", "pdf_views"=>"15", "xml_views"=>"1", "html_views"=>"44"}
  • {"month"=>"9", "year"=>"2018", "pdf_views"=>"23", "xml_views"=>"1", "html_views"=>"59"}
  • {"month"=>"10", "year"=>"2018", "pdf_views"=>"17", "xml_views"=>"0", "html_views"=>"39"}
  • {"month"=>"11", "year"=>"2018", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"35"}
  • {"month"=>"12", "year"=>"2018", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"31"}
  • {"month"=>"1", "year"=>"2019", "pdf_views"=>"22", "xml_views"=>"0", "html_views"=>"41"}
  • {"month"=>"2", "year"=>"2019", "pdf_views"=>"27", "xml_views"=>"0", "html_views"=>"35"}
  • {"month"=>"3", "year"=>"2019", "pdf_views"=>"19", "xml_views"=>"1", "html_views"=>"35"}
  • {"month"=>"4", "year"=>"2019", "pdf_views"=>"18", "xml_views"=>"0", "html_views"=>"50"}
  • {"month"=>"5", "year"=>"2019", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"30"}
  • {"month"=>"6", "year"=>"2019", "pdf_views"=>"19", "xml_views"=>"0", "html_views"=>"36"}
  • {"month"=>"7", "year"=>"2019", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"37"}
  • {"month"=>"8", "year"=>"2019", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"24"}
  • {"month"=>"9", "year"=>"2019", "pdf_views"=>"10", "xml_views"=>"1", "html_views"=>"27"}
  • {"month"=>"10", "year"=>"2019", "pdf_views"=>"21", "xml_views"=>"0", "html_views"=>"44"}
  • {"month"=>"11", "year"=>"2019", "pdf_views"=>"16", "xml_views"=>"0", "html_views"=>"24"}
  • {"month"=>"12", "year"=>"2019", "pdf_views"=>"22", "xml_views"=>"0", "html_views"=>"25"}
  • {"month"=>"1", "year"=>"2020", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"32"}
  • {"month"=>"2", "year"=>"2020", "pdf_views"=>"15", "xml_views"=>"0", "html_views"=>"25"}
  • {"month"=>"3", "year"=>"2020", "pdf_views"=>"15", "xml_views"=>"0", "html_views"=>"31"}
  • {"month"=>"4", "year"=>"2020", "pdf_views"=>"27", "xml_views"=>"0", "html_views"=>"30"}
  • {"month"=>"5", "year"=>"2020", "pdf_views"=>"39", "xml_views"=>"1", "html_views"=>"32"}
  • {"month"=>"6", "year"=>"2020", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"22"}
  • {"month"=>"7", "year"=>"2020", "pdf_views"=>"6", "xml_views"=>"2", "html_views"=>"6"}

Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/890579"], "description"=>"a<p>Median age was reported when mean age was not available. When mean age was not given for the <i>BRCA1</i> subset, the mean age of the entire series is reported.</p>b<p>See <a href=\"http://www.plosmedicine.org/article/info:doi/10.1371/journal.pmed.1000114#pmed.1000114.s010\" target=\"_blank\">Table S1</a> for rationale for exclusion/inclusion from prevalence calculations.</p><p>N, no; NS, age was not specified; Y, yes.</p>", "links"=>[], "tags"=>["occult"], "article_id"=>561037, "categories"=>["Virology", "Biotechnology", "Cancer"], "users"=>["Patrick O. Brown", "Chana Palmer"], "doi"=>"https://dx.doi.org/10.1371/journal.pmed.1000114.t001", "stats"=>{"downloads"=>1, "page_views"=>2, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Sources_of_occult_tumor_data_PBSO_studies_/561037", "title"=>"Sources of occult tumor data (PBSO studies).", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2009-07-28 00:17:17"}
  • {"files"=>["https://ndownloader.figshare.com/files/440997", "https://ndownloader.figshare.com/files/441005", "https://ndownloader.figshare.com/files/441014", "https://ndownloader.figshare.com/files/441023", "https://ndownloader.figshare.com/files/441039", "https://ndownloader.figshare.com/files/441048", "https://ndownloader.figshare.com/files/441061", "https://ndownloader.figshare.com/files/441075", "https://ndownloader.figshare.com/files/441086", "https://ndownloader.figshare.com/files/441094", "https://ndownloader.figshare.com/files/441104", "https://ndownloader.figshare.com/files/441119", "https://ndownloader.figshare.com/files/441131", "https://ndownloader.figshare.com/files/441143", "https://ndownloader.figshare.com/files/441149", "https://ndownloader.figshare.com/files/441158", "https://ndownloader.figshare.com/files/441169", "https://ndownloader.figshare.com/files/441172"], "description"=>"<div><h3>Background</h3><p>Ovarian cancer kills approximately 15,000 women in the United States every year, and more than 140,000 women worldwide. Most deaths from ovarian cancer are caused by tumors of the serous histological type, which are rarely diagnosed before the cancer has spread. Rational design of a potentially life-saving early detection and intervention strategy requires understanding the lesions we must detect in order to prevent lethal progression. Little is known about the natural history of lethal serous ovarian cancers before they become clinically apparent. We can learn about this occult period by studying the unsuspected serous cancers that are discovered in a small fraction of apparently healthy women who undergo prophylactic bilateral salpingo-oophorectomy (PBSO).</p><h3>Methods and Findings</h3><p>We developed models for the growth, progression, and detection of occult serous cancers on the basis of a comprehensive analysis of published data on serous cancers discovered by PBSO in <em>BRCA1</em> mutation carriers. Our analysis yielded several critical insights into the early natural history of serous ovarian cancer. First, these cancers spend on average more than 4 y as in situ, stage I, or stage II cancers and approximately 1 y as stage III or IV cancers before they become clinically apparent. Second, for most of the occult period, serous cancers are less than 1 cm in diameter, and not visible on gross examination of the ovaries and Fallopian tubes. Third, the median diameter of a serous ovarian cancer when it progresses to an advanced stage (stage III or IV) is about 3 cm. Fourth, to achieve 50% sensitivity in detecting tumors before they advance to stage III, an annual screen would need to detect tumors of 1.3 cm in diameter; 80% detection sensitivity would require detecting tumors less than 0.4 cm in diameter. Fifth, to achieve a 50% reduction in serous ovarian cancer mortality with an annual screen, a test would need to detect tumors of 0.5 cm in diameter.</p><h3>Conclusions</h3><p>Our analysis has formalized essential conditions for successful early detection of serous ovarian cancer. Although the window of opportunity for early detection of these cancers lasts for several years, developing a test sufficiently sensitive and specific to take advantage of that opportunity will be a challenge. We estimated that the tumors we would need to detect to achieve even 50% sensitivity are more than 200 times smaller than the clinically apparent serous cancers typically used to evaluate performance of candidate biomarkers; none of the biomarker assays reported to date comes close to the required level of performance. Overcoming the signal-to-noise problem inherent in detection of tiny tumors will likely require discovery of truly cancer-specific biomarkers or development of novel approaches beyond traditional blood protein biomarkers. While this study was limited to ovarian cancers of serous histological type and to those arising in <em>BRCA1</em> mutation carriers specifically, we believe that the results are relevant to other hereditary serous cancers and to sporadic ovarian cancers. A similar approach could be applied to other cancers to aid in defining their early natural history and to guide rational design of an early detection strategy.</p><h3></h3><p><em>Please see later in the article for Editors' Summary</em></p></div>", "links"=>[], "tags"=>["preclinical", "serous", "ovarian", "defining", "detection"], "article_id"=>146922, "categories"=>["Cancer", "Biotechnology"], "users"=>["Patrick O. Brown", "Chana Palmer"], "doi"=>["https://dx.doi.org/10.1371/journal.pmed.1000114.s001", "https://dx.doi.org/10.1371/journal.pmed.1000114.s002", "https://dx.doi.org/10.1371/journal.pmed.1000114.s003", "https://dx.doi.org/10.1371/journal.pmed.1000114.s004", "https://dx.doi.org/10.1371/journal.pmed.1000114.s005", "https://dx.doi.org/10.1371/journal.pmed.1000114.s006", "https://dx.doi.org/10.1371/journal.pmed.1000114.s007", "https://dx.doi.org/10.1371/journal.pmed.1000114.s008", "https://dx.doi.org/10.1371/journal.pmed.1000114.s009", "https://dx.doi.org/10.1371/journal.pmed.1000114.s010", "https://dx.doi.org/10.1371/journal.pmed.1000114.s011", "https://dx.doi.org/10.1371/journal.pmed.1000114.s012", "https://dx.doi.org/10.1371/journal.pmed.1000114.s013", "https://dx.doi.org/10.1371/journal.pmed.1000114.s014", "https://dx.doi.org/10.1371/journal.pmed.1000114.s015", "https://dx.doi.org/10.1371/journal.pmed.1000114.s016", "https://dx.doi.org/10.1371/journal.pmed.1000114.s017", "https://dx.doi.org/10.1371/journal.pmed.1000114.s018"], "stats"=>{"downloads"=>18, "page_views"=>57, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/The_Preclinical_Natural_History_of_Serous_Ovarian_Cancer_Defining_the_Target_for_Early_Detection/146922", "title"=>"The Preclinical Natural History of Serous Ovarian Cancer: Defining the Target for Early Detection", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2009-07-28 01:55:22"}
  • {"files"=>["https://ndownloader.figshare.com/files/890259"], "description"=>"<p>The boxes outlined in blue represent the data that were used to build the model. The boxes outlined in black represent critical steps in the modeling procedure. Data sources and modeling methods are described in <a href=\"http://www.plosmedicine.org/article/info:doi/10.1371/journal.pmed.1000114#s2\" target=\"_blank\">Methods</a>.</p>", "links"=>[], "tags"=>["modeling"], "article_id"=>560721, "categories"=>["Virology", "Biotechnology", "Cancer"], "users"=>["Patrick O. Brown", "Chana Palmer"], "doi"=>"https://dx.doi.org/10.1371/journal.pmed.1000114.g001", "stats"=>{"downloads"=>1, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Schematic_of_our_modeling_strategy_/560721", "title"=>"Schematic of our modeling strategy.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2009-07-28 00:12:01"}
  • {"files"=>["https://ndownloader.figshare.com/files/890331"], "description"=>"<p>Kaplan-Meier analysis was used to model tumor progression to late stage (III or IV) as a function of tumor diameter (see <a href=\"http://www.plosmedicine.org/article/info:doi/10.1371/journal.pmed.1000114#s2\" target=\"_blank\">Methods</a>). Observations were censored at the size of the tumor when discovered by PBSO. CIs are shown as indicated by the legend.</p>", "links"=>[], "tags"=>["progression"], "article_id"=>560797, "categories"=>["Virology", "Biotechnology", "Cancer"], "users"=>["Patrick O. Brown", "Chana Palmer"], "doi"=>"https://dx.doi.org/10.1371/journal.pmed.1000114.g002", "stats"=>{"downloads"=>1, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Tumor_progression_to_late_stage_as_a_function_of_tumor_diameter_/560797", "title"=>"Tumor progression to late stage as a function of tumor diameter.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2009-07-28 00:13:17"}
  • {"files"=>["https://ndownloader.figshare.com/files/890513"], "description"=>"a<p>Default values were as follows: percent understaging, 0%; size at clinical diagnosis (dx) (<i>BRCA1</i>) (see <a href=\"http://www.plosmedicine.org/article/info:doi/10.1371/journal.pmed.1000114#pmed.1000114.s012\" target=\"_blank\">Table S3</a>, reference <a href=\"http://www.plosmedicine.org/article/info:doi/10.1371/journal.pmed.1000114#pmed.1000114-vanNagell1\" target=\"_blank\">[35]</a>); size at clinical diagnosis (normal risk), 8 cm diameter; duration of occult period, 5.1 y (see <a href=\"http://www.plosmedicine.org/article/info:doi/10.1371/journal.pmed.1000114#s3\" target=\"_blank\">Results</a>); percent progressive tumors, 100%.</p>b<p>Values shown in first row were used as inputs into the model shown in <a href=\"http://www.plosmedicine.org/article/info:doi/10.1371/journal.pmed.1000114#pmed-1000114-g001\" target=\"_blank\">Figure 1</a>. All other variables were fixed at default values (see footnote a).</p>c<p>Values indicate the size of tumor (diameter) that an early detection test must detect in order to achieve 50% early detection sensitivity given the modified model input specified in the relevant column header.</p>d<p>Values shown indicate the size of tumor (diameter) that an early detection test must detect in order to achieve a 50% reduction in 5-y mortality given the modified model input specified in the relevant column header.</p>", "links"=>[], "tags"=>["systematic", "errors"], "article_id"=>560974, "categories"=>["Virology", "Biotechnology", "Cancer"], "users"=>["Patrick O. Brown", "Chana Palmer"], "doi"=>"https://dx.doi.org/10.1371/journal.pmed.1000114.t003", "stats"=>{"downloads"=>1, "page_views"=>1, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Sensitivity_analyses_effects_of_systematic_errors_in_model_inputs_/560974", "title"=>"Sensitivity analyses: effects of systematic errors in model inputs.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2009-07-28 00:16:14"}
  • {"files"=>["https://ndownloader.figshare.com/files/890384"], "description"=>"<p>The predicted sensitivity of a hypothetical early detection test is shown as a function of the tumor size detection threshold and frequency of a hypothetical screening test (see <a href=\"http://www.plosmedicine.org/article/info:doi/10.1371/journal.pmed.1000114#s2\" target=\"_blank\">Methods</a>). Results are shown for two populations of women: (A) Normal-risk women receiving normal care and monitoring; (B) High-risk women subjected to careful monitoring (e.g. <i>BRCA1</i> mutation carriers).</p>", "links"=>[], "tags"=>["detection"], "article_id"=>560842, "categories"=>["Virology", "Biotechnology", "Cancer"], "users"=>["Patrick O. Brown", "Chana Palmer"], "doi"=>"https://dx.doi.org/10.1371/journal.pmed.1000114.g003", "stats"=>{"downloads"=>3, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Early_detection_sensitivity_as_a_function_of_tumor_size_detection_threshold_/560842", "title"=>"Early detection sensitivity as a function of tumor size detection threshold.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2009-07-28 00:14:02"}
  • {"files"=>["https://ndownloader.figshare.com/files/890555"], "description"=>"<p>Abbreviation: FT, Fallopian tube.</p>", "links"=>[], "tags"=>["characteristics", "occult", "tumors", "BRCA1"], "article_id"=>561014, "categories"=>["Virology", "Biotechnology", "Cancer"], "users"=>["Patrick O. Brown", "Chana Palmer"], "doi"=>"https://dx.doi.org/10.1371/journal.pmed.1000114.t002", "stats"=>{"downloads"=>0, "page_views"=>2, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Summary_of_key_characteristics_of_occult_tumors_in_BRCA1_women_/561014", "title"=>"Summary of key characteristics of occult tumors in BRCA1 women.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2009-07-28 00:16:54"}
  • {"files"=>["https://ndownloader.figshare.com/files/890463"], "description"=>"<p>The predicted reduction in 5-y mortality from serous ovarian cancer is shown as a function of the tumor size detection threshold and frequency of a hypothetical screening test (see <a href=\"http://www.plosmedicine.org/article/info:doi/10.1371/journal.pmed.1000114#s2\" target=\"_blank\">Methods</a>). Results are shown for two populations of women: (A) Normal-risk women receiving normal care and monitoring; (B) High-risk women subjected to careful monitoring (e.g., <i>BRCA1</i> mutation carriers).</p>", "links"=>[], "tags"=>["5-y", "detection"], "article_id"=>560929, "categories"=>["Virology", "Biotechnology", "Cancer"], "users"=>["Patrick O. Brown", "Chana Palmer"], "doi"=>"https://dx.doi.org/10.1371/journal.pmed.1000114.g004", "stats"=>{"downloads"=>1, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Reduction_in_5_y_mortality_as_a_function_of_tumor_size_detection_threshold_/560929", "title"=>"Reduction in 5-y mortality as a function of tumor size detection threshold.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2009-07-28 00:15:29"}

PMC Usage Stats | Further Information

  • {"month"=>"1", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"9", "full-text"=>"50", "year"=>"2010", "pdf"=>"58", "unique-ip"=>"59", "figure"=>"4", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"2", "cited-by"=>"0", "abstract"=>"4", "full-text"=>"41", "unique-ip"=>"50", "pdf"=>"31", "year"=>"2010", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"3", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"4", "full-text"=>"50", "year"=>"2010", "pdf"=>"39", "unique-ip"=>"62", "figure"=>"12", "scanned-summary"=>"0", "supp-data"=>"3"}
  • {"scanned-page-browse"=>"0", "month"=>"4", "cited-by"=>"0", "abstract"=>"7", "full-text"=>"59", "unique-ip"=>"62", "pdf"=>"42", "year"=>"2010", "figure"=>"10", "scanned-summary"=>"0", "supp-data"=>"4"}
  • {"month"=>"5", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"5", "full-text"=>"41", "year"=>"2010", "pdf"=>"37", "unique-ip"=>"55", "figure"=>"6", "scanned-summary"=>"0", "supp-data"=>"1"}
  • {"scanned-page-browse"=>"0", "month"=>"6", "cited-by"=>"0", "abstract"=>"2", "full-text"=>"32", "unique-ip"=>"39", "pdf"=>"34", "year"=>"2010", "figure"=>"6", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"7", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"3", "full-text"=>"28", "year"=>"2010", "pdf"=>"17", "unique-ip"=>"28", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"8", "cited-by"=>"0", "abstract"=>"6", "full-text"=>"31", "unique-ip"=>"38", "pdf"=>"29", "year"=>"2010", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"9", "scanned-page-browse"=>"0", "cited-by"=>"1", "abstract"=>"4", "full-text"=>"42", "year"=>"2010", "pdf"=>"29", "unique-ip"=>"49", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"10", "cited-by"=>"0", "abstract"=>"11", "full-text"=>"26", "unique-ip"=>"40", "pdf"=>"27", "year"=>"2010", "figure"=>"1", "scanned-summary"=>"0", "supp-data"=>"1"}
  • {"month"=>"11", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"4", "full-text"=>"26", "year"=>"2010", "pdf"=>"14", "unique-ip"=>"34", "figure"=>"4", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"12", "cited-by"=>"0", "abstract"=>"5", "full-text"=>"20", "unique-ip"=>"21", "pdf"=>"9", "year"=>"2010", "figure"=>"2", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"1", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"5", "full-text"=>"35", "year"=>"2011", "pdf"=>"33", "unique-ip"=>"44", "figure"=>"4", "scanned-summary"=>"0", "supp-data"=>"1"}
  • {"scanned-page-browse"=>"0", "month"=>"2", "cited-by"=>"0", "abstract"=>"2", "full-text"=>"52", "unique-ip"=>"38", "pdf"=>"28", "year"=>"2011", "figure"=>"1", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"3", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"9", "full-text"=>"71", "year"=>"2011", "pdf"=>"40", "unique-ip"=>"67", "figure"=>"16", "scanned-summary"=>"0", "supp-data"=>"2"}
  • {"scanned-page-browse"=>"0", "month"=>"4", "cited-by"=>"0", "abstract"=>"11", "full-text"=>"39", "unique-ip"=>"43", "pdf"=>"28", "year"=>"2011", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"4"}
  • {"month"=>"5", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"7", "full-text"=>"28", "year"=>"2011", "pdf"=>"14", "unique-ip"=>"29", "figure"=>"4", "scanned-summary"=>"0", "supp-data"=>"7"}
  • {"scanned-page-browse"=>"0", "month"=>"6", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"23", "unique-ip"=>"25", "pdf"=>"16", "year"=>"2011", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"7", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"2", "full-text"=>"33", "year"=>"2011", "pdf"=>"14", "unique-ip"=>"28", "figure"=>"2", "scanned-summary"=>"0", "supp-data"=>"1"}
  • {"scanned-page-browse"=>"0", "month"=>"8", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"28", "unique-ip"=>"28", "pdf"=>"17", "year"=>"2011", "figure"=>"4", "scanned-summary"=>"0", "supp-data"=>"6"}
  • {"month"=>"9", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"57", "year"=>"2011", "pdf"=>"21", "unique-ip"=>"43", "figure"=>"7", "scanned-summary"=>"0", "supp-data"=>"8"}
  • {"scanned-page-browse"=>"0", "month"=>"10", "cited-by"=>"4", "abstract"=>"0", "full-text"=>"48", "unique-ip"=>"39", "pdf"=>"25", "year"=>"2011", "figure"=>"5", "scanned-summary"=>"0", "supp-data"=>"1"}
  • {"month"=>"11", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"2", "full-text"=>"44", "year"=>"2011", "pdf"=>"20", "unique-ip"=>"42", "figure"=>"13", "scanned-summary"=>"0", "supp-data"=>"1"}
  • {"scanned-page-browse"=>"0", "month"=>"12", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"30", "unique-ip"=>"27", "pdf"=>"15", "year"=>"2011", "figure"=>"3", "scanned-summary"=>"0", "supp-data"=>"1"}
  • {"scanned-page-browse"=>"0", "month"=>"1", "cited-by"=>"0", "abstract"=>"2", "full-text"=>"39", "unique-ip"=>"41", "pdf"=>"19", "year"=>"2012", "figure"=>"3", "scanned-summary"=>"0", "supp-data"=>"2"}
  • {"month"=>"2", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"38", "year"=>"2012", "pdf"=>"16", "unique-ip"=>"30", "figure"=>"1", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"3", "cited-by"=>"0", "abstract"=>"2", "full-text"=>"34", "unique-ip"=>"38", "pdf"=>"18", "year"=>"2012", "figure"=>"1", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"4", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"4", "full-text"=>"43", "year"=>"2012", "pdf"=>"16", "unique-ip"=>"42", "figure"=>"5", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"5", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"30", "unique-ip"=>"28", "pdf"=>"9", "year"=>"2012", "figure"=>"3", "scanned-summary"=>"0", "supp-data"=>"1"}
  • {"month"=>"7", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"3", "year"=>"2009", "pdf"=>"5", "unique-ip"=>"7", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"8", "cited-by"=>"0", "abstract"=>"7", "full-text"=>"159", "unique-ip"=>"131", "pdf"=>"93", "year"=>"2009", "figure"=>"14", "scanned-summary"=>"0", "supp-data"=>"9"}
  • {"month"=>"9", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"7", "full-text"=>"69", "year"=>"2009", "pdf"=>"50", "unique-ip"=>"75", "figure"=>"9", "scanned-summary"=>"0", "supp-data"=>"15"}
  • {"scanned-page-browse"=>"0", "month"=>"10", "cited-by"=>"0", "abstract"=>"7", "full-text"=>"37", "unique-ip"=>"46", "pdf"=>"29", "year"=>"2009", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"10"}
  • {"month"=>"11", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"14", "full-text"=>"78", "year"=>"2009", "pdf"=>"104", "unique-ip"=>"97", "figure"=>"5", "scanned-summary"=>"0", "supp-data"=>"1"}
  • {"scanned-page-browse"=>"0", "month"=>"12", "cited-by"=>"0", "abstract"=>"2", "full-text"=>"47", "unique-ip"=>"54", "pdf"=>"47", "year"=>"2009", "figure"=>"2", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"6", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"41", "year"=>"2012", "pdf"=>"17", "unique-ip"=>"36", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"unique-ip"=>"22", "full-text"=>"27", "pdf"=>"11", "abstract"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"21", "supp-data"=>"6", "cited-by"=>"0", "year"=>"2012", "month"=>"7"}
  • {"unique-ip"=>"6", "full-text"=>"6", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"8"}
  • {"unique-ip"=>"12", "full-text"=>"12", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"13", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"9"}
  • {"unique-ip"=>"12", "full-text"=>"12", "pdf"=>"10", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"10"}
  • {"unique-ip"=>"3", "full-text"=>"3", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"12"}
  • {"unique-ip"=>"8", "full-text"=>"10", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"1"}
  • {"unique-ip"=>"10", "full-text"=>"10", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"2"}
  • {"unique-ip"=>"9", "full-text"=>"10", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"4", "cited-by"=>"0", "year"=>"2013", "month"=>"3"}
  • {"unique-ip"=>"7", "full-text"=>"7", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2013", "month"=>"4"}
  • {"unique-ip"=>"6", "full-text"=>"6", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"11"}
  • {"unique-ip"=>"8", "full-text"=>"8", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"5"}
  • {"unique-ip"=>"10", "full-text"=>"9", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"6"}
  • {"unique-ip"=>"6", "full-text"=>"5", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"7"}
  • {"unique-ip"=>"8", "full-text"=>"11", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"18", "cited-by"=>"0", "year"=>"2013", "month"=>"8"}
  • {"unique-ip"=>"10", "full-text"=>"9", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"9"}
  • {"unique-ip"=>"12", "full-text"=>"11", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"10"}
  • {"unique-ip"=>"9", "full-text"=>"11", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2013", "month"=>"11"}
  • {"unique-ip"=>"8", "full-text"=>"8", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"12"}
  • {"unique-ip"=>"9", "full-text"=>"9", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"1"}
  • {"unique-ip"=>"15", "full-text"=>"17", "pdf"=>"13", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"2"}
  • {"unique-ip"=>"6", "full-text"=>"7", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"3"}
  • {"unique-ip"=>"9", "full-text"=>"6", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"5"}
  • {"unique-ip"=>"8", "full-text"=>"5", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"6"}
  • {"unique-ip"=>"5", "full-text"=>"4", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"4"}
  • {"unique-ip"=>"18", "full-text"=>"10", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"4", "cited-by"=>"0", "year"=>"2014", "month"=>"7"}
  • {"unique-ip"=>"9", "full-text"=>"8", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"8"}
  • {"unique-ip"=>"19", "full-text"=>"13", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2014", "month"=>"9"}
  • {"unique-ip"=>"16", "full-text"=>"17", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"10"}
  • {"unique-ip"=>"16", "full-text"=>"10", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"5", "cited-by"=>"0", "year"=>"2014", "month"=>"11"}
  • {"unique-ip"=>"15", "full-text"=>"10", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"4", "cited-by"=>"0", "year"=>"2014", "month"=>"12"}
  • {"unique-ip"=>"15", "full-text"=>"13", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"1"}
  • {"unique-ip"=>"9", "full-text"=>"16", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"4", "cited-by"=>"0", "year"=>"2015", "month"=>"2"}
  • {"unique-ip"=>"13", "full-text"=>"16", "pdf"=>"11", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"3"}
  • {"unique-ip"=>"11", "full-text"=>"15", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"4"}
  • {"unique-ip"=>"21", "full-text"=>"18", "pdf"=>"16", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2015", "month"=>"5"}
  • {"unique-ip"=>"14", "full-text"=>"15", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"6"}
  • {"unique-ip"=>"10", "full-text"=>"11", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2015", "month"=>"7"}
  • {"unique-ip"=>"13", "full-text"=>"8", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"8"}
  • {"unique-ip"=>"11", "full-text"=>"11", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"9"}
  • {"unique-ip"=>"17", "full-text"=>"16", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"11", "supp-data"=>"1", "cited-by"=>"1", "year"=>"2015", "month"=>"10"}
  • {"unique-ip"=>"14", "full-text"=>"11", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"2", "year"=>"2015", "month"=>"11"}
  • {"unique-ip"=>"35", "full-text"=>"38", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"12"}
  • {"unique-ip"=>"17", "full-text"=>"15", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"1"}
  • {"unique-ip"=>"10", "full-text"=>"12", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"3", "cited-by"=>"1", "year"=>"2016", "month"=>"2"}
  • {"unique-ip"=>"20", "full-text"=>"21", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2016", "month"=>"3"}
  • {"unique-ip"=>"8", "full-text"=>"10", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"4"}
  • {"unique-ip"=>"11", "full-text"=>"10", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"5"}
  • {"unique-ip"=>"13", "full-text"=>"14", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2016", "month"=>"6"}
  • {"unique-ip"=>"10", "full-text"=>"9", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"7"}
  • {"unique-ip"=>"9", "full-text"=>"9", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"8"}
  • {"unique-ip"=>"15", "full-text"=>"18", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"9"}
  • {"unique-ip"=>"10", "full-text"=>"10", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2016", "month"=>"10"}
  • {"unique-ip"=>"5", "full-text"=>"5", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"11"}
  • {"unique-ip"=>"16", "full-text"=>"15", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"12"}
  • {"unique-ip"=>"12", "full-text"=>"9", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"1"}
  • {"unique-ip"=>"7", "full-text"=>"14", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"2"}
  • {"unique-ip"=>"9", "full-text"=>"10", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"3"}
  • {"unique-ip"=>"15", "full-text"=>"19", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2017", "month"=>"4"}
  • {"unique-ip"=>"11", "full-text"=>"13", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2017", "month"=>"5"}
  • {"unique-ip"=>"3", "full-text"=>"3", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"6"}
  • {"unique-ip"=>"6", "full-text"=>"9", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"7"}
  • {"unique-ip"=>"12", "full-text"=>"18", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"13", "supp-data"=>"13", "cited-by"=>"0", "year"=>"2017", "month"=>"8"}
  • {"unique-ip"=>"9", "full-text"=>"13", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"4", "cited-by"=>"0", "year"=>"2017", "month"=>"9"}
  • {"unique-ip"=>"11", "full-text"=>"8", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2017", "month"=>"10"}
  • {"unique-ip"=>"8", "full-text"=>"8", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"11"}
  • {"unique-ip"=>"8", "full-text"=>"11", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2017", "month"=>"12"}
  • {"unique-ip"=>"6", "full-text"=>"7", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2018", "month"=>"1"}
  • {"unique-ip"=>"10", "full-text"=>"11", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2018", "month"=>"3"}
  • {"unique-ip"=>"15", "full-text"=>"18", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"1"}
  • {"unique-ip"=>"11", "full-text"=>"18", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"4"}
  • {"unique-ip"=>"10", "full-text"=>"9", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2018", "month"=>"6"}
  • {"unique-ip"=>"20", "full-text"=>"25", "pdf"=>"7", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"5"}
  • {"unique-ip"=>"12", "full-text"=>"8", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"8", "cited-by"=>"0", "year"=>"2018", "month"=>"7"}
  • {"unique-ip"=>"10", "full-text"=>"12", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"8"}
  • {"unique-ip"=>"27", "full-text"=>"17", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"9", "cited-by"=>"0", "year"=>"2018", "month"=>"9"}
  • {"unique-ip"=>"12", "full-text"=>"10", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"10"}
  • {"unique-ip"=>"17", "full-text"=>"18", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"5", "cited-by"=>"0", "year"=>"2018", "month"=>"11"}
  • {"unique-ip"=>"12", "full-text"=>"12", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"12"}
  • {"unique-ip"=>"14", "full-text"=>"17", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"5", "cited-by"=>"0", "year"=>"2019", "month"=>"2"}
  • {"unique-ip"=>"16", "full-text"=>"17", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"3"}
  • {"unique-ip"=>"16", "full-text"=>"13", "pdf"=>"7", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"4"}
  • {"unique-ip"=>"13", "full-text"=>"13", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"5"}
  • {"unique-ip"=>"15", "full-text"=>"15", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"8"}
  • {"unique-ip"=>"20", "full-text"=>"22", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2019", "month"=>"9"}
  • {"unique-ip"=>"31", "full-text"=>"35", "pdf"=>"8", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"15", "cited-by"=>"1", "year"=>"2019", "month"=>"10"}
  • {"unique-ip"=>"23", "full-text"=>"18", "pdf"=>"7", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"12"}
  • {"unique-ip"=>"25", "full-text"=>"27", "pdf"=>"7", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"2"}
  • {"unique-ip"=>"30", "full-text"=>"33", "pdf"=>"6", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"17", "cited-by"=>"0", "year"=>"2020", "month"=>"3"}
  • {"unique-ip"=>"26", "full-text"=>"31", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2020", "month"=>"4"}
  • {"unique-ip"=>"25", "full-text"=>"29", "pdf"=>"8", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2020", "month"=>"5"}

Relative Metric

{"start_date"=>"2009-01-01T00:00:00Z", "end_date"=>"2009-12-31T00:00:00Z", "subject_areas"=>[{"subject_area"=>"/Biology and life sciences/Anatomy", "average_usage"=>[342, 579, 717, 815, 916, 1016, 1128, 1233, 1326, 1409, 1498, 1583, 1649, 1726, 1805, 1871, 1941, 2005, 2074, 2130, 2182, 2233, 2290, 2334, 2405, 2443, 2493, 2539, 2605, 2666, 2714, 2773, 2834, 2886, 2961, 3012, 3075, 3126, 3185, 3258, 3314, 3381, 3458, 3519, 3587, 3633, 3709, 3756, 3830, 3880, 3943, 4014, 4062, 4131, 4184, 4235, 4288, 4331, 4398, 4440, 4505]}, {"subject_area"=>"/Biology and life sciences/Biochemistry", "average_usage"=>[335, 600, 731, 835, 935, 1034, 1138, 1230, 1320, 1399, 1485, 1570, 1643, 1714, 1791, 1859, 1928, 1987, 2040, 2104, 2157, 2210, 2261, 2320, 2373, 2432, 2486, 2543, 2603, 2655, 2720, 2787, 2844, 2901, 2952, 3005, 3065, 3119, 3176, 3236, 3305, 3373, 3432, 3492, 3558, 3614, 3676, 3736, 3801, 3869, 3930, 3973, 4031, 4096, 4176, 4234, 4283, 4338, 4405, 4464, 4512]}, {"subject_area"=>"/Medicine and health sciences/Anatomy", "average_usage"=>[339, 580, 713, 827, 926, 1032, 1153, 1258, 1348, 1429, 1522, 1603, 1687, 1772, 1834, 1905, 1972, 2029, 2098, 2151, 2214, 2275, 2335, 2388, 2446, 2496, 2553, 2604, 2653, 2705, 2780, 2822, 2890, 2947, 3020, 3070, 3114, 3162, 3226, 3285, 3353, 3433, 3500, 3547, 3592, 3639, 3700, 3769, 3858, 3922, 3967, 4028, 4069, 4137, 4191, 4246, 4302, 4372, 4436, 4498, 4579]}, {"subject_area"=>"/Medicine and health sciences/Anatomy and physiology", "average_usage"=>[319, 558, 683, 792, 899, 999, 1104, 1192, 1280, 1362, 1441, 1525, 1601, 1673, 1751, 1819, 1897, 1955, 2015, 2078, 2122, 2184, 2233, 2297, 2342, 2393, 2449, 2504, 2557, 2614, 2655, 2715, 2789, 2834, 2890, 2950, 3013, 3063, 3123, 3194, 3242, 3303, 3365, 3424, 3480, 3546, 3612, 3682]}, {"subject_area"=>"/Medicine and health sciences/Oncology", "average_usage"=>[338, 584, 737, 858, 964, 1086, 1213, 1320, 1412, 1515, 1612, 1699, 1776, 1851, 1931, 1997, 2085, 2165, 2218, 2278, 2340, 2409, 2472, 2541, 2586, 2661, 2713, 2754, 2817, 2889, 2946, 3006, 3064, 3105, 3167, 3234, 3300, 3357, 3420, 3485, 3546, 3609, 3687, 3741, 3790, 3844, 3893, 3957, 4013, 4062, 4105, 4140, 4220, 4268, 4330, 4375, 4438, 4493, 4540, 4573, 4616]}, {"subject_area"=>"/People and places", "average_usage"=>[340, 621, 760, 868, 956, 1048, 1152, 1251, 1334, 1414, 1499, 1591, 1663, 1753, 1823, 1893, 1955, 2026, 2094, 2178, 2255, 2327, 2390, 2467, 2535, 2613, 2680, 2731, 2780, 2851, 2909, 2986, 3049, 3107, 3177, 3238, 3292, 3360, 3437, 3503, 3564, 3622, 3710, 3812, 3860, 3932, 4002, 4075, 4112, 4156, 4247, 4296, 4386, 4455, 4550, 4613, 4662, 4694, 4869, 4937, 4982]}, {"subject_area"=>"/Physical sciences/Mathematics", "average_usage"=>[390, 657, 764, 869, 966, 1052, 1148, 1251, 1329, 1410, 1469, 1529, 1603, 1663, 1723, 1784, 1858, 1929, 1995, 2054, 2103, 2155, 2202, 2268, 2305, 2346, 2398, 2449, 2484, 2546, 2590, 2652, 2726, 2763, 2825, 2879, 2926, 2985, 3054, 3114, 3160, 3243, 3304, 3389, 3466, 3519, 3561, 3631, 3679, 3731, 3805, 3859, 3907, 3944, 3994, 4076, 4150, 4202, 4229, 4275, 4344, 4373]}]}
Loading … Spinner
There are currently no alerts