The Association of Factor V Leiden and Prothrombin Gene Mutation and Placenta-Mediated Pregnancy Complications: A Systematic Review and Meta-analysis of Prospective Cohort Studies
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{"title"=>"The association of factor V leiden and prothrombin gene mutation and placenta-mediated pregnancy complications: A systematic review and meta-analysis of prospective cohort studies", "type"=>"journal", "authors"=>[{"first_name"=>"Marc A.", "last_name"=>"Rodger", "scopus_author_id"=>"7003774260"}, {"first_name"=>"Marisol T.", "last_name"=>"Betancourt", "scopus_author_id"=>"23391981600"}, {"first_name"=>"Peter", "last_name"=>"Clark", "scopus_author_id"=>"7402579563"}, {"first_name"=>"Pelle G.", "last_name"=>"Lindqvist", "scopus_author_id"=>"56497242200"}, {"first_name"=>"Donna", "last_name"=>"Dizon-Townson", "scopus_author_id"=>"6603806580"}, {"first_name"=>"Joanne", "last_name"=>"Said", "scopus_author_id"=>"8147560200"}, {"first_name"=>"Uri", "last_name"=>"Seligsohn", "scopus_author_id"=>"7006001850"}, {"first_name"=>"Marc", "last_name"=>"Carrier", "scopus_author_id"=>"7101604968"}, {"first_name"=>"Ophira", "last_name"=>"Salomon", "scopus_author_id"=>"13008278500"}, {"first_name"=>"Ian A.", "last_name"=>"Greer", "scopus_author_id"=>"20234363700"}], "year"=>2010, "source"=>"PLoS Medicine", "identifiers"=>{"pui"=>"359258155", "doi"=>"10.1371/journal.pmed.1000292", "scopus"=>"2-s2.0-77955027422", "isbn"=>"1549-1676 (Electronic)\\r1549-1277 (Linking)", "pmid"=>"20563311", "sgr"=>"77955027422", "issn"=>"15491277"}, "id"=>"04a5b006-46aa-3db0-ad73-c8584e9247ff", "abstract"=>"BACKGROUND: Factor V Leiden (FVL) and prothrombin gene mutation (PGM) are common inherited thrombophilias. Retrospective studies variably suggest a link between maternal FVL/PGM and placenta-mediated pregnancy complications including pregnancy loss, small for gestational age, pre-eclampsia and placental abruption. Prospective cohort studies provide a superior methodologic design but require larger sample sizes to detect important effects. We undertook a systematic review and a meta-analysis of prospective cohort studies to estimate the association of maternal FVL or PGM carrier status and placenta-mediated pregnancy complications.\\n\\nMETHODS AND FINDINGS: A comprehensive search strategy was run in Medline and Embase. Inclusion criteria were: (1) prospective cohort design; (2) clearly defined outcomes including one of the following: pregnancy loss, small for gestational age, pre-eclampsia or placental abruption; (3) maternal FVL or PGM carrier status; (4) sufficient data for calculation of odds ratios (ORs). We identified 322 titles, reviewed 30 articles for inclusion and exclusion criteria, and included ten studies in the meta-analysis. The odds of pregnancy loss in women with FVL (absolute risk 4.2%) was 52% higher (OR = 1.52, 95% confidence interval [CI] 1.06-2.19) as compared with women without FVL (absolute risk 3.2%). There was no significant association between FVL and pre-eclampsia (OR = 1.23, 95% CI 0.89-1.70) or between FVL and SGA (OR = 1.0, 95% CI 0.80-1.25). PGM was not associated with pre-eclampsia (OR = 1.25, 95% CI 0.79-1.99) or SGA (OR 1.25, 95% CI 0.92-1.70).\\n\\nCONCLUSIONS: Women with FVL appear to be at a small absolute increased risk of late pregnancy loss. Women with FVL and PGM appear not to be at increased risk of pre-eclampsia or birth of SGA infants. Please see later in the article for the Editors' Summary.", "link"=>"http://www.mendeley.com/research/association-factor-v-leiden-prothrombin-gene-mutation-placentamediated-pregnancy-complications-syste-6", "reader_count"=>86, "reader_count_by_academic_status"=>{"Unspecified"=>5, "Professor > Associate Professor"=>8, "Librarian"=>2, "Researcher"=>19, "Student > Doctoral Student"=>3, "Student > Ph. D. Student"=>11, "Student > Postgraduate"=>9, "Student > Master"=>9, "Other"=>7, "Student > Bachelor"=>9, "Professor"=>4}, "reader_count_by_user_role"=>{"Unspecified"=>5, "Professor > Associate Professor"=>8, "Librarian"=>2, "Researcher"=>19, "Student > Doctoral Student"=>3, "Student > Ph. D. Student"=>11, "Student > Postgraduate"=>9, "Student > Master"=>9, "Other"=>7, "Student > Bachelor"=>9, "Professor"=>4}, "reader_count_by_subject_area"=>{"Unspecified"=>10, "Biochemistry, Genetics and Molecular Biology"=>5, "Nursing and Health Professions"=>1, "Medicine and Dentistry"=>54, "Agricultural and Biological Sciences"=>11, "Design"=>1, "Physics and Astronomy"=>2, "Social Sciences"=>1, "Immunology and Microbiology"=>1}, "reader_count_by_subdiscipline"=>{"Design"=>{"Design"=>1}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>54}, "Social Sciences"=>{"Social Sciences"=>1}, "Physics and Astronomy"=>{"Physics and Astronomy"=>2}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>11}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>5}, "Unspecified"=>{"Unspecified"=>10}}, "reader_count_by_country"=>{"Canada"=>1, "Netherlands"=>1, "Denmark"=>1, "United Kingdom"=>1, "France"=>1, "Spain"=>1}, "group_count"=>5}

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  • {"files"=>["https://ndownloader.figshare.com/files/846073"], "description"=>"<p>Odds of placenta-mediated pregnancy complications in PGM (homozygous or heterozygous)-positive women.</p>", "links"=>[], "tags"=>["placenta-mediated", "complications", "pgm"], "article_id"=>516523, "categories"=>["Medicine", "Hematology"], "users"=>["Marc A. Rodger", "Marisol T. Betancourt", "Peter Clark", "Pelle G. Lindqvist", "Donna Dizon-Townson", "Joanne Said", "Uri Seligsohn", "Marc Carrier", "Ophira Salomon", "Ian A. Greer"], "doi"=>"https://dx.doi.org/10.1371/journal.pmed.1000292.g003", "stats"=>{"downloads"=>2, "page_views"=>18, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Odds_of_placenta_mediated_pregnancy_complications_in_PGM_homozygous_or_heterozygous_positive_women_/516523", "title"=>"Odds of placenta-mediated pregnancy complications in PGM (homozygous or heterozygous)-positive women.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2010-06-15 01:48:43"}
  • {"files"=>["https://ndownloader.figshare.com/files/420640", "https://ndownloader.figshare.com/files/420684", "https://ndownloader.figshare.com/files/420760", "https://ndownloader.figshare.com/files/420827"], "description"=>"<div><h3>Background</h3><p>Factor V Leiden (FVL) and prothrombin gene mutation (PGM) are common inherited thrombophilias. Retrospective studies variably suggest a link between maternal FVL/PGM and placenta-mediated pregnancy complications including pregnancy loss, small for gestational age, pre-eclampsia and placental abruption. Prospective cohort studies provide a superior methodologic design but require larger sample sizes to detect important effects. We undertook a systematic review and a meta-analysis of prospective cohort studies to estimate the association of maternal FVL or PGM carrier status and placenta-mediated pregnancy complications.</p><h3>Methods and Findings</h3><p>A comprehensive search strategy was run in Medline and Embase. Inclusion criteria were: (1) prospective cohort design; (2) clearly defined outcomes including one of the following: pregnancy loss, small for gestational age, pre-eclampsia or placental abruption; (3) maternal FVL or PGM carrier status; (4) sufficient data for calculation of odds ratios (ORs). We identified 322 titles, reviewed 30 articles for inclusion and exclusion criteria, and included ten studies in the meta-analysis. The odds of pregnancy loss in women with FVL (absolute risk 4.2%) was 52% higher (OR = 1.52, 95% confidence interval [CI] 1.06–2.19) as compared with women without FVL (absolute risk 3.2%). There was no significant association between FVL and pre-eclampsia (OR = 1.23, 95% CI 0.89–1.70) or between FVL and SGA (OR = 1.0, 95% CI 0.80–1.25). PGM was not associated with pre-eclampsia (OR = 1.25, 95% CI 0.79–1.99) or SGA (OR 1.25, 95% CI 0.92–1.70).</p><h3>Conclusions</h3><p>Women with FVL appear to be at a small absolute increased risk of late pregnancy loss. Women with FVL and PGM appear not to be at increased risk of pre-eclampsia or birth of SGA infants.</p><h3></h3><p><em>Please see later in the article for the Editors' Summary</em></p></div>", "links"=>[], "tags"=>["leiden", "prothrombin", "mutation", "placenta-mediated", "systematic", "meta-analysis", "prospective", "cohort", "studies"], "article_id"=>143044, "categories"=>["Hematology", "Medicine"], "users"=>["Marc A. Rodger", "Marisol T. Betancourt", "Peter Clark", "Pelle G. Lindqvist", "Donna Dizon-Townson", "Joanne Said", "Uri Seligsohn", "Marc Carrier", "Ophira Salomon", "Ian A. Greer"], "doi"=>[nil, nil, nil, nil], "stats"=>{"downloads"=>59, "page_views"=>40, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/The_Association_of_Factor_V_Leiden_and_Prothrombin_Gene_Mutation_and_Placenta_Mediated_Pregnancy_Complications_A_Systematic_Review_and_Meta_analysis_of_Prospective_Cohort_Studies/143044", "title"=>"The Association of Factor V Leiden and Prothrombin Gene Mutation and Placenta-Mediated Pregnancy Complications: A Systematic Review and Meta-analysis of Prospective Cohort Studies", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2010-06-15 00:50:44"}
  • {"files"=>["https://ndownloader.figshare.com/files/846302"], "description"=>"<p>Abbreviations: +/−, heterozygous carrier; ++, homozygous carrier; NOS, Newcastle Ottawa Scale for cohort studies (maximum <i>n</i> of starts: selection, 4; compatibility, 2; outcome, 3); PA, placental abruption; PET, pre-eclampsia; PL, pregnancy loss.</p>", "links"=>[], "tags"=>["included"], "article_id"=>516760, "categories"=>["Medicine", "Hematology"], "users"=>["Marc A. Rodger", "Marisol T. Betancourt", "Peter Clark", "Pelle G. Lindqvist", "Donna Dizon-Townson", "Joanne Said", "Uri Seligsohn", "Marc Carrier", "Ophira Salomon", "Ian A. Greer"], "doi"=>"https://dx.doi.org/10.1371/journal.pmed.1000292.t001", "stats"=>{"downloads"=>0, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Characteristics_of_included_studies_/516760", "title"=>"Characteristics of included studies.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2010-06-15 01:52:40"}
  • {"files"=>["https://ndownloader.figshare.com/files/846163"], "description"=>"<p>FVL and composite placenta-mediated pregnancy complications.</p>", "links"=>[], "tags"=>["composite", "placenta-mediated"], "article_id"=>516618, "categories"=>["Medicine", "Hematology"], "users"=>["Marc A. Rodger", "Marisol T. Betancourt", "Peter Clark", "Pelle G. Lindqvist", "Donna Dizon-Townson", "Joanne Said", "Uri Seligsohn", "Marc Carrier", "Ophira Salomon", "Ian A. Greer"], "doi"=>"https://dx.doi.org/10.1371/journal.pmed.1000292.g004", "stats"=>{"downloads"=>1, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_FVL_and_composite_placenta_mediated_pregnancy_complications_/516618", "title"=>"FVL and composite placenta-mediated pregnancy complications.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2010-06-15 01:50:18"}
  • {"files"=>["https://ndownloader.figshare.com/files/845975"], "description"=>"<p>Odds of placenta-mediated pregnancy complications in FVL (homozygous or heterozygous)-positive women.</p>", "links"=>[], "tags"=>["placenta-mediated", "complications", "fvl"], "article_id"=>516427, "categories"=>["Medicine", "Hematology"], "users"=>["Marc A. Rodger", "Marisol T. Betancourt", "Peter Clark", "Pelle G. Lindqvist", "Donna Dizon-Townson", "Joanne Said", "Uri Seligsohn", "Marc Carrier", "Ophira Salomon", "Ian A. Greer"], "doi"=>"https://dx.doi.org/10.1371/journal.pmed.1000292.g002", "stats"=>{"downloads"=>1, "page_views"=>12, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Odds_of_placenta_mediated_pregnancy_complications_in_FVL_homozygous_or_heterozygous_positive_women_/516427", "title"=>"Odds of placenta-mediated pregnancy complications in FVL (homozygous or heterozygous)-positive women.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2010-06-15 01:47:07"}
  • {"files"=>["https://ndownloader.figshare.com/files/846250"], "description"=>"<p>PGM and composite placenta-mediated pregnancy complications.</p>", "links"=>[], "tags"=>["composite", "placenta-mediated"], "article_id"=>516700, "categories"=>["Medicine", "Hematology"], "users"=>["Marc A. Rodger", "Marisol T. Betancourt", "Peter Clark", "Pelle G. Lindqvist", "Donna Dizon-Townson", "Joanne Said", "Uri Seligsohn", "Marc Carrier", "Ophira Salomon", "Ian A. Greer"], "doi"=>"https://dx.doi.org/10.1371/journal.pmed.1000292.g005", "stats"=>{"downloads"=>1, "page_views"=>15, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_PGM_and_composite_placenta_mediated_pregnancy_complications_/516700", "title"=>"PGM and composite placenta-mediated pregnancy complications.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2010-06-15 01:51:40"}
  • {"files"=>["https://ndownloader.figshare.com/files/845881"], "description"=>"<p>Study selection.</p>", "links"=>[], "tags"=>["hematology", "hematology/coagulation disorders", "obstetrics/pregnancy"], "article_id"=>516334, "categories"=>["Medicine", "Hematology"], "users"=>["Marc A. Rodger", "Marisol T. Betancourt", "Peter Clark", "Pelle G. Lindqvist", "Donna Dizon-Townson", "Joanne Said", "Uri Seligsohn", "Marc Carrier", "Ophira Salomon", "Ian A. Greer"], "doi"=>"https://dx.doi.org/10.1371/journal.pmed.1000292.g001", "stats"=>{"downloads"=>1, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Study_selection_/516334", "title"=>"Study selection.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2010-06-15 01:45:34"}

PMC Usage Stats | Further Information

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