The Uptake and Accuracy of Oral Kits for HIV Self-Testing in High HIV Prevalence Setting: A Cross-Sectional Feasibility Study in Blantyre, Malawi
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{"title"=>"The uptake and accuracy of oral kits for HIV self-testing in high HIV prevalence setting: A cross-sectional feasibility study in Blantyre, Malawi", "type"=>"journal", "authors"=>[{"first_name"=>"Augustine Talumba", "last_name"=>"Choko", "scopus_author_id"=>"53979360400"}, {"first_name"=>"Nicola", "last_name"=>"Desmond", "scopus_author_id"=>"22953067700"}, {"first_name"=>"Emily L.", "last_name"=>"Webb", "scopus_author_id"=>"36657853300"}, {"first_name"=>"Kondwani", "last_name"=>"Chavula", "scopus_author_id"=>"53979312100"}, {"first_name"=>"Sue", "last_name"=>"Napierala-Mavedzenge", "scopus_author_id"=>"26423906100"}, {"first_name"=>"Charlotte A.", "last_name"=>"Gaydos", "scopus_author_id"=>"7006440649"}, {"first_name"=>"Simon D.", "last_name"=>"Makombe", "scopus_author_id"=>"8935124900"}, {"first_name"=>"Treza", "last_name"=>"Chunda", "scopus_author_id"=>"53979286700"}, {"first_name"=>"S. Bertel", "last_name"=>"Squire", "scopus_author_id"=>"37052780500"}, {"first_name"=>"Neil", "last_name"=>"French", "scopus_author_id"=>"34975060700"}, {"first_name"=>"Victor", "last_name"=>"Mwapasa", "scopus_author_id"=>"6506993204"}, {"first_name"=>"Elizabeth L.", "last_name"=>"Corbett", "scopus_author_id"=>"7006955721"}], "year"=>2011, "source"=>"PLoS Medicine", "identifiers"=>{"issn"=>"15491277", "scopus"=>"2-s2.0-80055029916", "sgr"=>"80055029916", "pui"=>"362826626", "isbn"=>"1549-1277", "pmid"=>"21990966", "doi"=>"10.1371/journal.pmed.1001102"}, "id"=>"033fa0a5-f63a-3500-9d99-5dc9e064c36c", "abstract"=>"BACKGROUND: Although HIV testing and counseling (HTC) uptake has increased dramatically in Africa, facility-based services are unlikely to ever meet ongoing need to the full. A major constraint in scaling up community and home-based HTC services is the unacceptability of receiving HTC from a provider known personally to prospective clients. We investigated the potential of supervised oral HIV self-testing from this perspective. METHODS AND FINDINGS: Adult members of 60 households and 72 members of community peer groups in urban Blantyre, Malawi, were selected using population-weighted random cluster sampling. Participants were offered self-testing plus confirmatory HTC (parallel testing with two rapid finger-prick blood tests), standard HTC alone, or no testing. 283 (95.6%) of 298 selected adults participated, including 136 (48.0%) men. 175 (61.8%) had previously tested (19 known HIV positive), although only 64 (21.5%) within the last year. HIV prevalence was 18.5%. Among 260 (91.9%) who opted to self-test after brief demonstration and illustrated instructions, accuracy was 99.2% (two false negatives). Although 98.5% rated the test \"not hard at all to do,\" 10.0% made minor procedural errors, and 10.0% required extra help. Most participants indicated willingness to accept self-test kits, but not HTC, from a neighbor (acceptability 94.5% versus 46.8%, p = 0.001). CONCLUSIONS: Oral supervised self-testing was highly acceptable and accurate, although minor errors and need for supervisory support were common. This novel option has potential for high uptake at local community level if it can be supervised and safely linked to counseling and care.", "link"=>"http://www.mendeley.com/research/uptake-accuracy-oral-kits-hiv-selftesting-high-hiv-prevalence-setting-crosssectional-feasibility-stu", "reader_count"=>138, "reader_count_by_academic_status"=>{"Unspecified"=>5, "Professor > Associate Professor"=>5, "Librarian"=>2, "Researcher"=>37, "Student > Doctoral Student"=>9, "Student > Ph. D. Student"=>20, "Student > Postgraduate"=>5, "Student > Master"=>35, "Other"=>8, "Student > Bachelor"=>5, "Lecturer"=>2, "Lecturer > Senior Lecturer"=>1, "Professor"=>4}, "reader_count_by_user_role"=>{"Unspecified"=>5, "Professor > Associate Professor"=>5, "Librarian"=>2, "Researcher"=>37, "Student > Doctoral Student"=>9, "Student > Ph. D. Student"=>20, "Student > Postgraduate"=>5, "Student > Master"=>35, "Other"=>8, "Student > Bachelor"=>5, "Lecturer"=>2, "Lecturer > Senior Lecturer"=>1, "Professor"=>4}, "reader_count_by_subject_area"=>{"Unspecified"=>15, "Agricultural and Biological Sciences"=>9, "Arts and Humanities"=>2, "Business, Management and Accounting"=>4, "Chemistry"=>3, "Computer Science"=>1, "Economics, Econometrics and Finance"=>1, "Environmental Science"=>1, "Biochemistry, Genetics and Molecular Biology"=>1, "Nursing and Health Professions"=>13, "Materials Science"=>1, "Mathematics"=>1, "Medicine and Dentistry"=>49, "Psychology"=>1, "Social Sciences"=>35, "Immunology and Microbiology"=>1}, "reader_count_by_subdiscipline"=>{"Materials Science"=>{"Materials Science"=>1}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>49}, "Social Sciences"=>{"Social Sciences"=>35}, "Psychology"=>{"Psychology"=>1}, "Mathematics"=>{"Mathematics"=>1}, "Unspecified"=>{"Unspecified"=>15}, "Environmental Science"=>{"Environmental Science"=>1}, "Arts and Humanities"=>{"Arts and Humanities"=>2}, "Chemistry"=>{"Chemistry"=>3}, "Economics, Econometrics and Finance"=>{"Economics, Econometrics and Finance"=>1}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>9}, "Computer Science"=>{"Computer Science"=>1}, "Business, Management and Accounting"=>{"Business, Management and Accounting"=>4}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>13}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>1}}, "reader_count_by_country"=>{"Argentina"=>1, "United States"=>2, "Malawi"=>1, "Japan"=>1, "South Africa"=>1, "United Kingdom"=>1, "Zimbabwe"=>1, "France"=>1, "Kenya"=>1, "Switzerland"=>3, "India"=>1}, "group_count"=>12}

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  • {"files"=>["https://ndownloader.figshare.com/files/727912"], "description"=>"a<p>Question only asked to those who accepted self-testing (100 women and 97 men).</p><p>*<i>F</i>-test adjusted for the clustered design.</p><p>ND, not determined.</p>", "links"=>[], "tags"=>["acceptability", "hiv"], "article_id"=>398258, "categories"=>["Biotechnology"], "users"=>["Augustine Talumba Choko", "Nicola Desmond", "Emily L. Webb", "Kondwani Chavula", "Sue Napierala-Mavedzenge", "Charlotte A. Gaydos", "Simon D. Makombe", "Treza Chunda", "S. Bertel Squire", "Neil French", "Victor Mwapasa", "Elizabeth L. Corbett"], "doi"=>"https://dx.doi.org/10.1371/journal.pmed.1001102.t004", "stats"=>{"downloads"=>1, "page_views"=>11, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Preferences_and_acceptability_of_HIV_testing_and_counseling_options_/398258", "title"=>"Preferences and acceptability of HIV testing and counseling options.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-20 14:05:45"}
  • {"files"=>["https://ndownloader.figshare.com/files/727865"], "description"=>"<p>Participants with no confirmatory results are not included in sensitivity and specificity analyses. Inconclusive results are considered to be inaccurate (false) results in sensitivity and specificity analyses.</p>", "links"=>[], "tags"=>["tabulation", "oraquick", "confirmatory", "hiv"], "article_id"=>398207, "categories"=>["Biotechnology"], "users"=>["Augustine Talumba Choko", "Nicola Desmond", "Emily L. Webb", "Kondwani Chavula", "Sue Napierala-Mavedzenge", "Charlotte A. Gaydos", "Simon D. Makombe", "Treza Chunda", "S. Bertel Squire", "Neil French", "Victor Mwapasa", "Elizabeth L. Corbett"], "doi"=>"https://dx.doi.org/10.1371/journal.pmed.1001102.t002", "stats"=>{"downloads"=>0, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Cross_tabulation_of_OraQuick_and_confirmatory_blood_test_results_in_all_participants_and_participants_not_already_known_to_be_HIV_positive_/398207", "title"=>"Cross tabulation of OraQuick and confirmatory blood test results in all participants and participants not already known to be HIV positive.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-20 14:05:30"}

PMC Usage Stats | Further Information

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Relative Metric

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