Absorbable Versus Silk Sutures for Surgical Treatment of Trachomatous Trichiasis in Ethiopia: A Randomised Controlled Trial
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{"title"=>"Absorbable versus silk sutures for surgical treatment of trachomatous trichiasis in Ethiopia: A randomised controlled trial", "type"=>"generic", "authors"=>[{"first_name"=>"Saul N.", "last_name"=>"Rajak", "scopus_author_id"=>"54879564900"}, {"first_name"=>"Esmael", "last_name"=>"Habtamu", "scopus_author_id"=>"39261595000"}, {"first_name"=>"Helen A.", "last_name"=>"Weiss", "scopus_author_id"=>"7403112967"}, {"first_name"=>"Amir Bedri", "last_name"=>"Kello", "scopus_author_id"=>"7801322801"}, {"first_name"=>"Teshome", "last_name"=>"Gebre", "scopus_author_id"=>"24472675600"}, {"first_name"=>"Asrat", "last_name"=>"Genet", "scopus_author_id"=>"23987844600"}, {"first_name"=>"Robin L.", "last_name"=>"Bailey", "scopus_author_id"=>"7402652011"}, {"first_name"=>"David C.W.", "last_name"=>"Mabey", "scopus_author_id"=>"56400433900"}, {"first_name"=>"Peng T.", "last_name"=>"Khaw", "scopus_author_id"=>"7006578947"}, {"first_name"=>"Clare E.", "last_name"=>"Gilbert", "scopus_author_id"=>"7201382726"}, {"first_name"=>"Paul M.", "last_name"=>"Emerson", "scopus_author_id"=>"7006957525"}, {"first_name"=>"Matthew J.", "last_name"=>"Burton", "scopus_author_id"=>"7202920109"}], "year"=>2011, "source"=>"PLoS Medicine", "identifiers"=>{"pmid"=>"22180732", "doi"=>"10.1371/journal.pmed.1001137", "sgr"=>"84855180573", "isbn"=>"1549-1676", "scopus"=>"2-s2.0-84855180573", "issn"=>"15491277", "pui"=>"364014901"}, "id"=>"a57605c3-4416-3ab1-ac5d-558661655857", "abstract"=>"BACKGROUND: Trachoma causes blindness through an anatomical abnormality called trichiasis (lashes touching the eye). Trichiasis can recur after corrective surgery. We tested the hypothesis that using absorbable sutures instead of silk sutures might reduce the risk of recurrent disease among patients with major trichiasis in a randomised trial.\\n\\nMETHODS AND FINDINGS: 1,300 individuals with major trichiasis from rural villages in the Amhara Region of Ethiopia were recruited and assigned (1:1) by computer-generated randomisation sequence to receive trichiasis surgery using either an absorbable suture (polyglactin-910) or silk sutures (removed at 7-10 days) in an otherwise identical surgical technique. Participants were examined every 6 months for 2 years by clinicians masked to allocation. The primary outcome measure was recurrent trichiasis (≥one lash touching the eye) at 1 year. There was no difference in prevalence of recurrent trichiasis at 1 year (114 [18.2%] in the absorbable suture group versus 120 [19.7%] in the silk suture group; odds ratio = 0.90, 95% CI 0.68-1.20). The two groups also did not differ in terms of corneal opacification, visual acuity, conjunctival inflammation, and surgical complications.\\n\\nCONCLUSIONS: There was no evidence that use of absorbable polyglactin-910 sutures was associated with a lower prevalence of trichiasis recurrence at 1 year postsurgery than silk sutures. However, from a programmatic perspective, polyglactin-910 offers the major advantage that patients do not have to be seen soon after surgery for suture removal. The postoperative review after surgery using absorbable polyglactin-910 sutures can be delayed for 3-6 months, which might allow us to better determine whether a patient needs additional surgery.\\n\\nTRIAL REGISTRATION: ClinicalTrials.gov NCT00522860.", "link"=>"http://www.mendeley.com/research/absorbable-versus-silk-sutures-surgical-treatment-trachomatous-trichiasis-ethiopia-randomised-contro", "reader_count"=>42, "reader_count_by_academic_status"=>{"Unspecified"=>3, "Researcher"=>8, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>9, "Student > Postgraduate"=>3, "Student > Master"=>8, "Other"=>4, "Student > Bachelor"=>3, "Lecturer > Senior Lecturer"=>2, "Professor"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>3, "Researcher"=>8, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>9, "Student > Postgraduate"=>3, "Student > Master"=>8, "Other"=>4, "Student > Bachelor"=>3, "Lecturer > Senior Lecturer"=>2, "Professor"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>3, "Environmental Science"=>1, "Nursing and Health Professions"=>1, "Medicine and Dentistry"=>22, "Agricultural and Biological Sciences"=>9, "Business, Management and Accounting"=>1, "Psychology"=>3, "Social Sciences"=>2}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>22}, "Social Sciences"=>{"Social Sciences"=>2}, "Psychology"=>{"Psychology"=>3}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>9}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>1}, "Business, Management and Accounting"=>{"Business, Management and Accounting"=>1}, "Unspecified"=>{"Unspecified"=>3}, "Environmental Science"=>{"Environmental Science"=>1}}, "reader_count_by_country"=>{"Tanzania"=>1, "Kenya"=>1}, "group_count"=>5}

Scopus | Further Information

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  • {"files"=>["https://ndownloader.figshare.com/files/703519"], "description"=>"a<p>Participants with bilateral TT had one eye randomly selected as the trial eye.</p>b<p>Unable to cooperate with visual acuity measurement.</p>c<p>Examination of the tarsal conjunctiva was not possible in one individual.</p><p>CF, count fingers; BMI, body mass index; HM, hand movements; PL, perception of light; NPL, no perception of light; SD, standard deviation; VA, visual acuity.</p>", "links"=>[], "tags"=>["characteristics", "follow-up", "assessments"], "article_id"=>373873, "categories"=>["Medicine", "Infectious Diseases"], "users"=>["Saul N. Rajak", "Esmael Habtamu", "Helen A. Weiss", "Amir Bedri Kello", "Teshome Gebre", "Asrat Genet", "Robin L. Bailey", "David C. W. Mabey", "Peng T. Khaw", "Clare E. Gilbert", "Paul M. Emerson", "Matthew J. Burton"], "doi"=>"https://dx.doi.org/10.1371/journal.pmed.1001137.t001", "stats"=>{"downloads"=>0, "page_views"=>2, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Baseline_characteristics_and_number_of_follow_up_assessments_of_participants_by_study_arm_/373873", "title"=>"Baseline characteristics and number of follow-up assessments of participants, by study arm.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2011-12-13 01:04:33"}
  • {"files"=>["https://ndownloader.figshare.com/files/703419"], "description"=>"b<p>Undissolved suture identified at 3 mo.</p>a<p>Fisher exact test.</p>", "links"=>[], "tags"=>["postoperative"], "article_id"=>373777, "categories"=>["Medicine", "Infectious Diseases"], "users"=>["Saul N. Rajak", "Esmael Habtamu", "Helen A. Weiss", "Amir Bedri Kello", "Teshome Gebre", "Asrat Genet", "Robin L. Bailey", "David C. W. Mabey", "Peng T. Khaw", "Clare E. Gilbert", "Paul M. Emerson", "Matthew J. Burton"], "doi"=>"https://dx.doi.org/10.1371/journal.pmed.1001137.t005", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Intra_and_postoperative_complications_by_study_arm_/373777", "title"=>"Intra- and postoperative complications, by study arm.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2011-12-13 01:02:57"}
  • {"files"=>["https://ndownloader.figshare.com/files/356998", "https://ndownloader.figshare.com/files/357098", "https://ndownloader.figshare.com/files/357305"], "description"=>"<div><h3>Background</h3><p>Trachoma causes blindness through an anatomical abnormality called trichiasis (lashes touching the eye). Trichiasis can recur after corrective surgery. We tested the hypothesis that using absorbable sutures instead of silk sutures might reduce the risk of recurrent disease among patients with major trichiasis in a randomised trial.</p> <h3>Methods and Findings</h3><p>1,300 individuals with major trichiasis from rural villages in the Amhara Region of Ethiopia were recruited and assigned (1∶1) by computer-generated randomisation sequence to receive trichiasis surgery using either an absorbable suture (polyglactin-910) or silk sutures (removed at 7–10 days) in an otherwise identical surgical technique. Participants were examined every 6 months for 2 years by clinicians masked to allocation. The primary outcome measure was recurrent trichiasis (≥one lash touching the eye) at 1 year. There was no difference in prevalence of recurrent trichiasis at 1 year (114 [18.2%] in the absorbable suture group versus 120 [19.7%] in the silk suture group; odds ratio = 0.90, 95% CI 0.68–1.20). The two groups also did not differ in terms of corneal opacification, visual acuity, conjunctival inflammation, and surgical complications.</p> <h3>Conclusions</h3><p>There was no evidence that use of absorbable polyglactin-910 sutures was associated with a lower prevalence of trichiasis recurrence at 1 year postsurgery than silk sutures. However, from a programmatic perspective, polyglactin-910 offers the major advantage that patients do not have to be seen soon after surgery for suture removal. The postoperative review after surgery using absorbable polyglactin-910 sutures can be delayed for 3–6 months, which might allow us to better determine whether a patient needs additional surgery.</p> <h3>Trial registration</h3><p><a href=\"http://ClinicalTrials.gov\">ClinicalTrials.gov</a><a href=\"http://clinicaltrials.gov/ct2/show/NCT00522860\">NCT00522860</a></p> <h3></h3><p> <em>Please see later in the article for the Editors' Summary</em></p> </div>", "links"=>[], "tags"=>["absorbable", "sutures", "surgical", "trachomatous", "trichiasis", "randomised", "controlled"], "article_id"=>130548, "categories"=>["Medicine", "Cancer"], "users"=>["Saul N. Rajak", "Esmael Habtamu", "Helen A. Weiss", "Amir Bedri Kello", "Teshome Gebre", "Asrat Genet", "Robin L. Bailey", "David C. W. Mabey", "Peng T. Khaw", "Clare E. Gilbert", "Paul M. Emerson", "Matthew J. Burton"], "doi"=>["https://dx.doi.org/10.1371/journal.pmed.1001137.s001", "https://dx.doi.org/10.1371/journal.pmed.1001137.s002", "https://dx.doi.org/10.1371/journal.pmed.1001137.s003"], "stats"=>{"downloads"=>8, "page_views"=>16, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Absorbable_Versus_Silk_Sutures_for_Surgical_Treatment_of_Trachomatous_Trichiasis_in_Ethiopia_A_Randomised_Controlled_Trial/130548", "title"=>"Absorbable Versus Silk Sutures for Surgical Treatment of Trachomatous Trichiasis in Ethiopia: A Randomised Controlled Trial", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2011-12-13 00:09:08"}
  • {"files"=>["https://ndownloader.figshare.com/files/703360"], "description"=>"<p>Kaplan-Meier graph of time to failure.</p>", "links"=>[], "tags"=>["graph"], "article_id"=>373719, "categories"=>["Medicine", "Infectious Diseases"], "users"=>["Saul N. Rajak", "Esmael Habtamu", "Helen A. Weiss", "Amir Bedri Kello", "Teshome Gebre", "Asrat Genet", "Robin L. Bailey", "David C. W. Mabey", "Peng T. Khaw", "Clare E. Gilbert", "Paul M. Emerson", "Matthew J. Burton"], "doi"=>"https://dx.doi.org/10.1371/journal.pmed.1001137.g002", "stats"=>{"downloads"=>1, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Kaplan_Meier_graph_of_time_to_failure_/373719", "title"=>"Kaplan-Meier graph of time to failure.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-12-13 01:01:59"}
  • {"files"=>["https://ndownloader.figshare.com/files/703628"], "description"=>"a<p>Includes individuals who had received repeat surgery, but had not developed a second episode of postoperative recurrence.</p>b<p>Denominators are the number of cases performed by each surgeon, % values are the recurrences.</p><p>CF, count fingers; HM, hand movements; PL, perception of light; NPL, no perception of light; VA, visual acuity.</p>", "links"=>[], "tags"=>["characteristics", "12", "24"], "article_id"=>373977, "categories"=>["Medicine", "Infectious Diseases"], "users"=>["Saul N. Rajak", "Esmael Habtamu", "Helen A. Weiss", "Amir Bedri Kello", "Teshome Gebre", "Asrat Genet", "Robin L. Bailey", "David C. W. Mabey", "Peng T. Khaw", "Clare E. Gilbert", "Paul M. Emerson", "Matthew J. Burton"], "doi"=>"https://dx.doi.org/10.1371/journal.pmed.1001137.t002", "stats"=>{"downloads"=>1, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Clinical_characteristics_of_participants_at_12_and_24_mo_by_study_arm_/373977", "title"=>"Clinical characteristics of participants at 12 and 24 mo, by study arm.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2011-12-13 01:06:17"}
  • {"files"=>["https://ndownloader.figshare.com/files/703566"], "description"=>"a<p>Deterioration of two or more lines on LogMAR visual acuity chart.</p>b<p>Presence of entropion, grade 2 or more.</p>", "links"=>[], "tags"=>["associations", "measures", "sutures", "compared"], "article_id"=>373916, "categories"=>["Medicine", "Infectious Diseases"], "users"=>["Saul N. Rajak", "Esmael Habtamu", "Helen A. Weiss", "Amir Bedri Kello", "Teshome Gebre", "Asrat Genet", "Robin L. Bailey", "David C. W. Mabey", "Peng T. Khaw", "Clare E. Gilbert", "Paul M. Emerson", "Matthew J. Burton"], "doi"=>"https://dx.doi.org/10.1371/journal.pmed.1001137.t003", "stats"=>{"downloads"=>1, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Univariate_associations_between_outcome_measures_and_study_arm_polyglactin_910_sutures_compared_to_silk_sutures_/373916", "title"=>"Univariate associations between outcome measures and study arm (polyglactin-910 sutures compared to silk sutures).", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2011-12-13 01:05:16"}
  • {"files"=>["https://ndownloader.figshare.com/files/703244"], "description"=>"<p>Trial profile.</p>", "links"=>[], "tags"=>["Infectious diseases", "ophthalmology", "surgery"], "article_id"=>373598, "categories"=>["Medicine", "Infectious Diseases"], "users"=>["Saul N. Rajak", "Esmael Habtamu", "Helen A. Weiss", "Amir Bedri Kello", "Teshome Gebre", "Asrat Genet", "Robin L. Bailey", "David C. W. Mabey", "Peng T. Khaw", "Clare E. Gilbert", "Paul M. Emerson", "Matthew J. Burton"], "doi"=>"https://dx.doi.org/10.1371/journal.pmed.1001137.g001", "stats"=>{"downloads"=>1, "page_views"=>2, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Trial_profile_/373598", "title"=>"Trial profile.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-12-13 00:59:58"}
  • {"files"=>["https://ndownloader.figshare.com/files/703476"], "description"=>"<p>*<i>p</i>-Value for trend.</p><p>**<i>p</i>-Value for heterogeneity.</p>", "links"=>[], "tags"=>["multivariable", "logistic", "regression", "models", "recurrent", "trichiasis"], "article_id"=>373823, "categories"=>["Medicine", "Infectious Diseases"], "users"=>["Saul N. Rajak", "Esmael Habtamu", "Helen A. Weiss", "Amir Bedri Kello", "Teshome Gebre", "Asrat Genet", "Robin L. Bailey", "David C. W. Mabey", "Peng T. Khaw", "Clare E. Gilbert", "Paul M. Emerson", "Matthew J. Burton"], "doi"=>"https://dx.doi.org/10.1371/journal.pmed.1001137.t004", "stats"=>{"downloads"=>1, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Univariate_analysis_and_multivariable_logistic_regression_models_for_any_recurrent_trichiasis_at_1_or_2_y_following_surgery_/373823", "title"=>"Univariate analysis and multivariable logistic regression models for any recurrent trichiasis at 1 or 2 y following surgery.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2011-12-13 01:03:43"}

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Relative Metric

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