HIV Treatment as Prevention: Debate and Commentary—Will Early Infection Compromise Treatment-as-Prevention Strategies?
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{"title"=>"HIV treatment as prevention: Debate and commentary-will early infection compromise treatment-as-prevention strategies?", "type"=>"journal", "authors"=>[{"first_name"=>"Myron S.", "last_name"=>"Cohen", "scopus_author_id"=>"54790532400"}, {"first_name"=>"Christopher", "last_name"=>"Dye", "scopus_author_id"=>"34770166000"}, {"first_name"=>"Christophe", "last_name"=>"Fraser", "scopus_author_id"=>"35460815100"}, {"first_name"=>"William C.", "last_name"=>"Miller", "scopus_author_id"=>"7406061778"}, {"first_name"=>"Kimberly A.", "last_name"=>"Powers", "scopus_author_id"=>"7006194043"}, {"first_name"=>"Brian G.", "last_name"=>"Williams", "scopus_author_id"=>"55499079300"}], "year"=>2012, "source"=>"PLoS Medicine", "identifiers"=>{"issn"=>"15491277", "scopus"=>"2-s2.0-84864476583", "sgr"=>"84864476583", "pui"=>"365352077", "isbn"=>"1549-1676 (Electronic)\\r1549-1277 (Linking)", "pmid"=>"22802728", "doi"=>"10.1371/journal.pmed.1001232"}, "id"=>"8f7f6b13-3727-39e0-a89d-fd15895b0556", "abstract"=>"Universal HIV testing and immediate antiretroviral therapy for infected individuals has been proposed as a way of reducing the transmission of HIV and thereby bringing the HIV epidemic under control. It is unclear whether transmission during early HIV infection--before individuals are likely to have been diagnosed with HIV and started on antiretroviral therapy--will compromise the effectiveness of treatment as prevention. This article presents two opposing viewpoints by Powers, Miller, and Cohen, and Williams and Dye, followed by a commentary by Fraser.", "link"=>"http://www.mendeley.com/research/hiv-treatment-prevention-debate-commentarywill-early-infection-compromise-treatmentasprevention-stra", "reader_count"=>73, "reader_count_by_academic_status"=>{"Unspecified"=>2, "Professor > Associate Professor"=>1, "Student > Doctoral Student"=>9, "Researcher"=>19, "Student > Ph. D. Student"=>18, "Student > Postgraduate"=>2, "Student > Master"=>10, "Other"=>3, "Student > Bachelor"=>2, "Lecturer"=>1, "Professor"=>6}, "reader_count_by_user_role"=>{"Unspecified"=>2, "Professor > Associate Professor"=>1, "Student > Doctoral Student"=>9, "Researcher"=>19, "Student > Ph. D. Student"=>18, "Student > Postgraduate"=>2, "Student > Master"=>10, "Other"=>3, "Student > Bachelor"=>2, "Lecturer"=>1, "Professor"=>6}, "reader_count_by_subject_area"=>{"Unspecified"=>9, "Environmental Science"=>2, "Nursing and Health Professions"=>4, "Materials Science"=>1, "Mathematics"=>3, "Medicine and Dentistry"=>30, "Agricultural and Biological Sciences"=>10, "Business, Management and Accounting"=>3, "Physics and Astronomy"=>1, "Chemistry"=>1, "Social Sciences"=>8, "Economics, Econometrics and Finance"=>1}, "reader_count_by_subdiscipline"=>{"Materials Science"=>{"Materials Science"=>1}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>30}, "Chemistry"=>{"Chemistry"=>1}, "Social Sciences"=>{"Social Sciences"=>8}, "Physics and Astronomy"=>{"Physics and Astronomy"=>1}, "Economics, Econometrics and Finance"=>{"Economics, Econometrics and Finance"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>10}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>4}, "Business, Management and Accounting"=>{"Business, Management and Accounting"=>3}, "Mathematics"=>{"Mathematics"=>3}, "Unspecified"=>{"Unspecified"=>9}, "Environmental Science"=>{"Environmental Science"=>2}}, "reader_count_by_country"=>{"Netherlands"=>1, "United States"=>3, "Nigeria"=>1, "Switzerland"=>1}, "group_count"=>6}

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  • {"files"=>["https://ndownloader.figshare.com/files/612837"], "description"=>"<p>(A) Green line: prevalence; red line: incidence. Two versions of a model are fitted to the adult HIV prevalence curve for South Africa (Joint United Nations Programme on HIV/AIDS): one “corrected” for serial monogamy effects in low-risk individuals <a href=\"http://www.plosmedicine.org/article/info:doi/10.1371/journal.pmed.1001232#pmed.1001232-Cohen1\" target=\"_blank\">[5]</a>, and thus with a low contribution of AHI (solid line), and one without the correction, and thus with a high contribution of AHI (dashed line). Fitted parameters are as follows: the proportion of individuals in three risk groups (low, medium, and high), rate of partner change for high-risk individuals, assortativity of mixing by risk, start time, early treatment rates, and an overall infectiousness parameter. Other parameters were fixed from the literature <a href=\"http://www.plosmedicine.org/article/info:doi/10.1371/journal.pmed.1001232#pmed.1001232-Cohen3\" target=\"_blank\">[13]</a>,<a href=\"http://www.plosmedicine.org/article/info:doi/10.1371/journal.pmed.1001232#pmed.1001232-Gardner1\" target=\"_blank\">[14]</a>. (C) The intervention is introduced in 2012, and predictions are made until 2020, for three scenarios ranging from the very pessimistic (green line), through “just on target” (red line), to very optimistic (blue line). The results are surprisingly independent of the amount of transmission from AHI, as indicated by the solid versus dashed lines. (B and D) The contribution to transmission from individuals in different disease stages in the just-on-target scenarios is plotted in (B), corresponding to solid lines in (A) and (C) (corrected for serial monogamy effects), and (D), corresponding to dashed lines in (A) and (C) (not corrected for serial monogamy effects). Shown are all new infections of index cases in AHI and EHI (green), of index cases in untreated CHI (blue), and of index cases in treated CHI (red), as a proportion of total new infections.</p>", "links"=>[], "tags"=>["levels", "acute", "tested", "popart"], "article_id"=>283328, "categories"=>["Medicine"], "users"=>["Myron S. Cohen", "Christopher Dye", "Christophe Fraser", "William C. Miller", "Kimberly A. Powers", "Brian G. Williams"], "doi"=>["https://dx.doi.org/10.1371/journal.pmed.1001232.g001"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_The_predicted_effect_of_different_levels_of_acute_infection_on_a_combination_prevention_package_including_universal_testing_and_treatment_as_will_be_tested_in_the_PopART_trial_20_/283328", "title"=>"The predicted effect of different levels of acute infection on a combination prevention package including universal testing and treatment, as will be tested in the PopART trial [20].", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 02:50:39"}

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  • {"unique-ip"=>"18", "full-text"=>"17", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"6"}
  • {"unique-ip"=>"13", "full-text"=>"9", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"7"}
  • {"unique-ip"=>"20", "full-text"=>"19", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"8"}
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  • {"unique-ip"=>"37", "full-text"=>"43", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"11"}
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Relative Metric

{"start_date"=>"2012-01-01T00:00:00Z", "end_date"=>"2012-12-31T00:00:00Z", "subject_areas"=>[{"subject_area"=>"/Biology and life sciences/Microbiology", "average_usage"=>[339, 580, 709, 814, 907, 1003, 1095, 1190, 1286, 1375, 1466, 1546, 1622, 1694, 1765, 1830, 1902, 1978, 2054, 2122, 2194, 2269, 2330, 2388, 2460]}, {"subject_area"=>"/Medicine and health sciences/Immunology", "average_usage"=>[307, 545, 668, 765, 855, 943, 1029, 1113, 1202, 1285, 1361, 1439, 1506, 1571, 1636, 1706, 1772, 1837, 1901, 1969, 2031, 2096, 2160, 2228, 2287]}, {"subject_area"=>"/People and places/Population groupings", "average_usage"=>[325, 565, 687, 787, 880, 971, 1065, 1156, 1244, 1339, 1424, 1502, 1582, 1654, 1724, 1794, 1855, 1925, 1997, 2058, 2132, 2207, 2285, 2347, 2412]}]}
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